Ligia M Saraiva (821D-BBFC-F470)

Curriculum Vitae

Ligia M Saraiva

Lígia M. Saraiva is a Full Professor in Biochemistry in ITQB-NOVA. She leads the Molecular Mechanisms of Pathogen Resistance Lab that has as main focus to study the Survival Mechanisms of Human Pathogens, by investigating the following areas: i) Microbial Heme Biosynthesis; ii); bacterial defenses against Oxidative and Nitrosative Stress imposed by the innate immune system, and iii) development of Carbon Monoxide Releasing Compounds (CORMs) as new antimicrobials. The research aims at characterizing microbial phenotypes under stress conditions and deciphering the role of genes/proteins in specific bacterial metabolisms, using a multidisciplinary approach encompassing molecular genetics, microbiology, and biochemistry. She has authored over 130 articles in international journals and holds 2 registered patents (Google Scholar: H-index 41, citations >5200). Over the years, she has supervised 14 PhD theses and has been involved as a Principal Investigator or co-PI in more than 25 research projects.

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Identification

Personal identification

Full name: Ligia M Saraiva

Citation names

Saraiva, Ligia M

Author identifiers

Ciência ID: 821D-BBFC-F470
ORCID iD: 0000-0002-0675-129X
Google Scholar ID: https://scholar.google.com/citations?user=HBdOMucAAAAJ&hl=en
Researcher Id: H-8537-2012
Scopus Author Id: 7005249012

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)

Education

	Degree	Classification
2011/06/05 Concluded	Microbial Physiology (Título de Agregado) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
1993 Concluded	Bioquímica (Doutoramento) Major in Especialidade: Bioquímica Física Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal "Citocromos de Bactérias Desnitrificantes - Análise Bioquímica e Espectroscópica" (THESIS/DISSERTATION)
1987/12/30 Concluded	Engenharia Química (Mestrado integrado) Universidade de Lisboa Instituto Superior Técnico, Portugal

Affiliation

Science

	Category Host institution	Employer
2004/01/02 - 2020/09/01	Principal Investigator (Research)	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2020/10/01 - Current	Full Professor (University Teacher)	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Positions / Appointments

	Category Host institution	Employer
2018/06 - Current	Member of General Council	Universidade Nova de Lisboa, Portugal
	Universidade Nova de Lisboa, Portugal
2018 - 2019	Member of General Council	Universidade Nova de Lisboa, Portugal
	Universidade Nova de Lisboa, Portugal

Projects

Contract

	Designation	Funders
2021/01/01 - 2025/12/31	Life Sciences for a Healthy and Sustainable Future LA/P/0087/2020 10.54499/LA/P/0087/2020 Universidade Nova de Lisboa, Portugal Universidade Nova de Lisboa Microbiologia Molecular Estrutural e Celular, Portugal Universidade de Trás-os-Montes e Alto Douro Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas, Portugal Instituto de Biologia Experimental e Tecnológica, Portugal Instituto Gulbenkian de Ciência, Portugal Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal Universidade de Lisboa Centro de Estudos Comparatistas, Portugal BioResources 4 Sustainability, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2022/01/01 - 2024/12/31	Interaction of RIC with iron-sulfur biogenesis systems FCT PTDC/BIA- MIC/0268/2021 Principal investigator Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia
2022/01/01 - 2024/12/31	Interaction of RIC with iron-sulfur biogenesis systems PTDC/BIA-MIC/0268/2021 10.54499/PTDC/BIA-MIC/0268/2021 Universidade Nova de Lisboa, Portugal BioResources 4 Sustainability, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2022/01/01 - 2024/12/31	Interaction of RIC with iron-sulfur biogenesis systems PTDC/BIA-MIC/0268/2021 10.54499/PTDC/BIA-MIC/0268/2021 Universidade Nova de Lisboa, Portugal BioResources 4 Sustainability, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2022/01 - 2024/12	Interaction of RIC with iron-sulfur biogenesis systems FCT PTDC/BIA- MIC/0268/2021	Fundação para a Ciência e a Tecnologia
2022/01/01 - 2023/12/31	Metabolomics for the Identification of Biomarkers for Early Diagnosis of Lower Respiratory Tract Infections EXPL/BTM-TEC/1019/2021 10.54499/EXPL/BTM-TEC/1019/2021 Universidade Nova de Lisboa, Portugal Universidade Nova de Lisboa Microbiologia Molecular Estrutural e Celular, Portugal Centro Hospitalar Universitário de Santo António, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2021/04/01 - 2023/03/31	Novel Strategy to cope with Multidrug Resistant Pathogens 101003441 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Ongoing
2018/10/01 - 2022/09/30	Diversity and complexity of microbial multidomain oxygen and/or nitric oxide reductases flavodiiron enzymes from Clostridiales PTDC/BIA-BQM/27959/2017 Universidade Nova de Lisboa, Portugal Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018/10/01 - 2022/09/30	Role of bacterial haem biosynthesis in host-pathogen interaction PTDC/BIA-BQM/28642/2017 Universidade Nova de Lisboa, Portugal Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018/10/01 - 2022/09/30	Staphylococcus epidermidis adaptation to nitric oxide produced by the innate immune system PTDC/BIA-MIC/31566/2017 Universidade Nova de Lisboa, Portugal Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018/10/01 - 2022/04/30	Exploring the Antimicrobial Potential of Carbon Monoxide-Releasing Molecules PTDC/SAU-INF/29313/2017 Universidade Nova de Lisboa, Portugal Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018/10/01 - 2021/10/01	The role of heme bacterial biosynthesis in pathogen-host interaction FCT-PTDC/BIA-BQM/28642/2017 Principal investigator Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Ongoing
2018/10/01 - 2021/10/01	Exploring the Antimicrobial Potential of Carbon-Monoxide-Releasing-Molecules PTDC/SAU-INF/29313/2017 Researcher Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Ongoing
2018/10/01 - 2021/10/01	Adaptation of Staphylococcus epidermidis to stress imposed by the innate immune system FCT-PTDC/BIA-MIC/31566/2017 Researcher Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Ongoing
2018/10 - 2021/10	The role of heme bacterial biosynthesis in pathogen-host interaction FCT-PTDC/BIA-BQM/28642/2017	N/A
2018/10 - 2021/10	Adaptation of Staphylococcus epidermidis to stress imposed by the innate immune system FCT-PTDC/BIA-MIC/31566/2017	N/A
2018/10/01 - 2021/09/30	Exploring the Antimicrobial Potential of Carbon Monoxide-Releasing Molecules PTDC/SAU-INF/29313/2017 Universidade Nova de Lisboa, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/10/01 - 2021/09/30	Role of bacterial haem biosynthesis in host-pathogen interaction PTDC/BIA-BQM/28642/2017 Universidade Nova de Lisboa, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/10/01 - 2021/09/30	Staphylococcus epidermidis adaptation to nitric oxide produced by the innate immune system PTDC/BIA-MIC/31566/2017 Universidade Nova de Lisboa, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/10/01 - 2021/09/30	Exploring the Antimicrobial Potential of Carbon Monoxide-Releasing Molecules PTDC/SAU-INF/29313/2017 Universidade Nova de Lisboa, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/10/01 - 2021/09/30	Role of bacterial haem biosynthesis in host-pathogen interaction PTDC/BIA-BQM/28642/2017 Universidade Nova de Lisboa, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/10/01 - 2021/09/30	Staphylococcus epidermidis adaptation to nitric oxide produced by the innate immune system PTDC/BIA-MIC/31566/2017 Universidade Nova de Lisboa, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/09/01 - 2021/09/01	Twin to Illuminate Metals in Biology and Biocatalysis through Biospectroscopy. Widespread Twinning Action Horizon 2020. Widespread Twinning Action Horizon 2020. Researcher	Ongoing
2019/01/01 - 2019/12/31	Molecular, Structural and Cellular Microbiology UID/CBQ/04612/2019 Universidade Nova de Lisboa, Portugal Universidade Nova de Lisboa Microbiologia Molecular Estrutural e Celular, Portugal Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2019/01/01 - 2019/12/31	Microbiologia Molecular, Estrutural e Celular UID/CBQ/04612/2019 Universidade Nova de Lisboa, Portugal Universidade Nova de Lisboa Microbiologia Molecular Estrutural e Celular, Portugal Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2016/05/01 - 2019/10/31	Diiron proteins in the microbial response to oxidative or nitrosative stress PTDC/BBB-BQB/3135/2014 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal BioResources 4 Sustainability, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2016/05/01 - 2019/08/31	Biosynthesis of modified tetrapyrroles in Staphyloccocus aureus PTDC/BBB-BQB/5069/2014 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2016/05/01 - 2019/08/31	Biosynthesis of modified tetrapyrroles in Staphyloccocus aureus PTDC/BBB-BQB/5069/2014 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2016/05/01 - 2019/08/31	Biosynthesis of modified tetrapyrroles in Staphyloccocus aureus PTDC/BBB-BQB/5069/2014 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2015/09/01 - 2018/09/01	Diiron proteins in the microbial response to oxidative or nitrosative stress. FCT-PTDC/BBB-BQB/3135/2014. Principal investigator	Concluded
2015/09 - 2018/09	Diiron proteins in the microbial response to oxidative or nitrosative stress. FCT-PTDC/BBB-BQB/3135/2014.	N/A
2013/07/01 - 2015/09/30	Heme biosynthesis in Staphylococcus aureus:old bug new challenges PTDC/BBB-BQB/0937/2012 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2013/07/01 - 2015/09/30	Heme biosynthesis in Staphylococcus aureus:old bug new challenges PTDC/BBB-BQB/0937/2012 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2013/07/01 - 2015/09/30	Heme biosynthesis in Staphylococcus aureus:old bug new challenges PTDC/BBB-BQB/0937/2012 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2013/09/01 - 2015/09/01	Heme biosynthesis in Staphylococcus aureus: old bug new challenges FCT-PTDC/BBB-BQB/0937/2012 Principal investigator Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Concluded
2013/09 - 2015/09	Heme biosynthesis in Staphylococcus aureus: old bug new challenges FCT-PTDC/BBB-BQB/0937/2012	N/A
2010/01/01 - 2013/06/30	Functional study of a diiron protein with the unique role of repairing iron-sulphur clusters PTDC/BIA-PRO/098224/2008 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2010/01/01 - 2013/06/30	Unraveling the mechanisms of nitrosative stress resistance of Helicobacter pylori: relevance for immune subversion and infectiousness PTDC/SAU-MII/098086/2008 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2010/01/01 - 2013/06/30	Functional study of a diiron protein with the unique role of repairing iron-sulphur clusters PTDC/BIA-PRO/098224/2008 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2010/01/01 - 2013/06/30	Unraveling the mechanisms of nitrosative stress resistance of Helicobacter pylori: relevance for immune subversion and infectiousness PTDC/SAU-MII/098086/2008 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2010/01/01 - 2013/06/30	Functional study of a diiron protein with the unique role of repairing iron-sulphur clusters PTDC/BIA-PRO/098224/2008 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2010/01/01 - 2013/06/30	Unraveling the mechanisms of nitrosative stress resistance of Helicobacter pylori: relevance for immune subversion and infectiousness PTDC/SAU-MII/098086/2008 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal Institut Pasteur, France	Fundação para a Ciência e a Tecnologia Concluded
2011/01/01 - 2012/12/31	Strategic Project - LA 4 - 2011-2012 PEst-OE/EQB/LA0004/2011 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal Universidade NOVA de Lisboa NOVA Medical School, Portugal Universidade de Trás-os-Montes e Alto Douro Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas, Portugal Instituto de Biologia Experimental e Tecnológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2009/01/01 - 2012/12/31	Investigation of redox-state-specific protein-protein interactions and energy transduction in the electron transfer chains of sulfate reducing bacteria PTDC/QUI/65640/2006 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2008/01/01 - 2011/12/31	Identification and characterization of the supercomplexes from the bacterial aerobic respiratory chain of Escherichia coli and Bacillus subtilis PTDC/BIA-PRO/67105/2006 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal Instituto de Investigação Científica Tropical, Portugal Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2008/01/01 - 2011/11/30	Microbial enzymes involved in superoxide and nitric oxide reduction PTDC/BIA-PRO/67263/2006 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2008/01/01 - 2011/11/30	Microbial enzymes involved in superoxide and nitric oxide reduction PTDC/BIA-PRO/67263/2006 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2008/01/01 - 2011/11/30	Microbial enzymes involved in superoxide and nitric oxide reduction PTDC/BIA-PRO/67263/2006 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2008/01/01 - 2011/03/31	Iron Metabolism Study in Deinococcus radiodurans- Novel strategies PTDC/BIA-PRO/67240/2006 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal Universidade de Lisboa Faculdade de Ciências, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2008/01/01 - 2011/02/28	Quinol oxidation by membrane cytochromes c widely implicated in bacterial respiration - structural studies of the model NrfHA complex PTDC/BIA-PRO/68486/2006 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2008/01/01 - 2011/02/28	Quinol oxidation by membrane cytochromes c widely implicated in bacterial respiration - structural studies of the model NrfHA complex PTDC/BIA-PRO/68486/2006 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2008/01/01 - 2011/02/28	Quinol oxidation by membrane cytochromes c widely implicated in bacterial respiration - structural studies of the model NrfHA complex PTDC/BIA-PRO/68486/2006 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2008/02/01 - 2011/01/31	Iron metabolism in sulphate reducing bacteria PTDC/BIA-PRO/67107/2006 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2008/02/01 - 2011/01/31	Iron metabolism in sulphate reducing bacteria PTDC/BIA-PRO/67107/2006 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2008/02/01 - 2011/01/31	Iron metabolism in sulphate reducing bacteria PTDC/BIA-PRO/67107/2006 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2007/11/12 - 2010/12/31	Understanding sulfate respiration at molecular level: studies of two conserved membrane complexes PTDC/QUI/68368/2006 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2007/11/12 - 2010/12/31	Understanding sulfate respiration at molecular level: studies of two conserved membrane complexes PTDC/QUI/68368/2006 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2007/11/12 - 2010/12/31	Understanding sulfate respiration at molecular level: studies of two conserved membrane complexes PTDC/QUI/68368/2006 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2005/09/01 - 2008/03/31	Nitrosative Stress Responses of Human Pathogens POCI/SAU-IMI/56088/2004 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2005/09/01 - 2008/03/31	Nitrosative Stress Responses of Human Pathogens POCI/SAU-IMI/56088/2004 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2005/09/01 - 2008/03/31	Nitrosative Stress Responses of Human Pathogens POCI/SAU-IMI/56088/2004 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2005/09/01 - 2007/06/30	Characterisation of a membrane bound cytochrome involved in the anaerobic respiration in Sulfate Reducing Bacteria POCI/QUI/55690/2004 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2005/09/01 - 2007/06/30	Characterisation of a membrane bound cytochrome involved in the anaerobic respiration in Sulfate Reducing Bacteria POCI/QUI/55690/2004 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2005/09/01 - 2007/06/30	Characterisation of a membrane bound cytochrome involved in the anaerobic respiration in Sulfate Reducing Bacteria POCI/QUI/55690/2004 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Book	Nobre, L.S.; Saraiva, L.M.. Di-iron RICs: Players in Nitrosative-oxidative Stress Defences. 2016. 10.1002/9781119004813.ch96 Lobo, S.A.L.; Warren, M.J.; Saraiva, L.M.. Sulfate-Reducing Bacteria Reveal a New Branch of Tetrapyrrole Metabolism. 2012. 10.1016/B978-0-12-394423-8.00007-X Vicente, J.B.; Justino, M.C.; Gonçalves, V.L.; Saraiva, L.M.; Teixeira, M.. Biochemical, Spectroscopic, and Thermodynamic Properties of Flavodiiron Proteins. 2008. 10.1016/S0076-6879(07)37002-X Nobre, L.S.; Gonçalves, V.L.; Saraiva, L.M.. Flavohemoglobin of Staphylococcus aureus. 2008. 10.1016/S0076-6879(08)36011-X Saraiva, L.M.; Vicente, J.B.; Teixeira, M.. The role of the flavodiiron proteins in microbial nitric oxide detoxification. 2004. 10.1016/S0065-2911(04)49002-X
Book chapter	Carvalho, Sandra M.; Beas, Jordi Zamarreño; Videira, Marco A.M.; Saraiva, Lígia M.. "Defenses of multidrug resistant pathogens against reactive nitrogen species produced in infected hosts". In Advances in Microbial Physiology, 85-155. Elsevier, 2022. 10.1016/bs.ampbs.2022.02.001
Book review	Mendes, Sofia S.; Miranda, Vanessa; Saraiva, Lígia M.. "Hydrogen sulfide and carbon monoxide tolerance in bacteria". http://hdl.handle.net/10362/128802. https://doi.org/10.3390/antiox10050729 Zamarreño Beas, Jordi; Videira, Marco A.M.; Saraiva, Lígia M.. "Regulation of bacterial haem biosynthesis". http://hdl.handle.net/10362/153047. https://doi.org/10.1016/j.ccr.2021.214286
Conference paper	Todorovic, S.; Nobre, L.S.; Tavares, A.F.N.; Hildebrandt, P.; Teixeira, M.S.; Saraiva, L.M.. "Disentangling interactions of an azole antibiotic with a flavohemoglobin from S. aureus". 2010. 10.1063/1.3482863
Conference poster	Ana Santos Oliveira; Saraiva, Ligia M; Carvalho, Sandra Margarida. Corresponding author: Carvalho, Sandra Margarida. "Staphylococcus epidermidis biofilm metabolism and matrix remodelling promotes resistance to nitrosative stress". Paper presented in 13th ITQB NOVA PhD Students' Meeting, October 18-20, 2023, Oeiras, Portugal, 2023. Ana Santos Oliveira; Saraiva, Ligia M; Carvalho, Sandra Margarida. Corresponding author: Carvalho, Sandra Margarida. "Strategies of Staphylococcus epidermidis biofilms to survive nitric oxide produced by immune cells". Paper presented in New approaches and concepts in microbiology, June 27-30, 2023, Heidelberg, Germany, 2023. Ana Santos Oliveira; Saraiva, Ligia M; Carvalho, Sandra Margarida. "Study of the metabolic adaptation of Staphylococcus epidermidis biofilms to nitrosative stress". Paper presented in Twin to illuminate metal in biology and biocatalysis through biospectroscopy (TIMB3), Tomar, Portugal, 2022. Carvalho, Sandra Margarida; Cruz, Hugo; Ana Santos Oliveira; Saraiva, Ligia M. "Untargeted 1H-NMR metabolomics of bronchoalveolar lavages fluids for biomarker discovery for respiratory tract infectious diseases". Paper presented in Twin to illuminate metal in biology and biocatalysis through biospectroscopy (TIMB3), Tomar, Portugal, 2022. Ana Santos Oliveira; Cruz, Hugo; Saraiva, Ligia M; Carvalho, Sandra Margarida. Corresponding author: Carvalho, Sandra Margarida. "Uncovering bronchoalveolar lavage fluids biomarkers for diagnosis of lower respiratory tract infectious agents". Paper presented in 18th International Conference of the Metabolomics Society, Metabolomics 22, Valência, Spain, 2022. Zamarreno Beas, Jordi; Videira, Marco A.M; Batista, Joana; Saraiva, Ligia M. "Haem biosynthesis in Gram-negative pathogens". Paper presented in Microbiotec21, 2021. Ana Santos Oliveira; Saraiva, Ligia M; Carvalho, Sandra Margarida. "Insights into the adaptation of Staphylococcus epidermidis biofilms to effectors of the immune system". Paper presented in Microbiotech, online, Portugal, 2021. Zamarreno Beas, Jordi; Videira, Marco A.M; Batista, Joana; Saraiva, Ligia M. Corresponding author: Saraiva, Ligia M. "Study of haem biosynthesis in multidrug resistant pathogens". Paper presented in IV International Conference NOVAhealth Chronic Disease and Infection, 2021. Ana Santos Oliveira; Saraiva, Ligia M; Carvalho, Sandra Margarida. "A glimpse into the phenotypic adaptation of Staphylococcus epidermidis biofilms to nitrosative stress". Paper presented in IV International Conference NOVAhealth Chronic Disease and Infection, Lisbon, Portugal, 2021. Zamarreno Beas, Jordi; Videira, Marco A.M; Batista, Joana; Saraiva, Ligia M. Corresponding author: Saraiva, Ligia M. "Haem biosynthesis in Campylobacter jejuni". Paper presented in NOVAhealth Chronic Disease and Infection: Infection, Cancer and Global Health, 2020. Apura P; Peregrina A; Viegas, SC; Saramago, Margarida; Carvalho, Sandra Margarida; Saraiva, Ligia M; Domingues SM; Arraiano CM. "Small noncoding RNAs as a tool to modulate gene expression". Paper presented in 6th Joint Conference of the DGHM & VAAM, Leipzig, 2020. Carvalho, Sandra Margarida; Freitas, CS; kuipers OP; Saraiva, Ligia M. "Metabolic adaptation of Staphylococcus aureus to antimicrobial nitrosative stress imposed by host innate immunity". Paper presented in Microbiotech, Coimbra, Portugal, 2019. Carvalho, Sandra Margarida; Marques J; Carlos C. Romão; Saraiva, Ligia M. "Using metabolomics to assess the effect of the antimicrobial carbon monoxide-releasing molecule-3 in Escherichia coli central metabolic enzymes.". Paper presented in Microbiotech, Coimbra, Portugal, 2019. Carvalho, Sandra Margarida; Freitas, CS; Saraiva, Ligia M. "Staphylococcus epidermidis - coping with the host immune system". Paper presented in Microbiotech, Coimbra, Portugal, 2019. Zamarreno Beas, Jordi; Batista, Joana; Videira, Marco A.M; Saraiva, Ligia M. "Haem metabolism in human pathogens". Paper presented in Microbiotec19, 2019. Mendes SS; Carvalho, Sandra Margarida; Mesterhazy E; Romão CC; Saraiva, Ligia M. "Development of novel antimicrobial carbon monoxide-releasing molecules and insights into their mechanism of action". Paper presented in 1st TIMB3 Annual Meeting, Carcavelos, Portugal, 2019. 10.1158/1538-7445.am2019-2077 Videira, Marco André Moras; Lobo, Susana A.L.; Silva, Liliana S.O; David J. Palmer; Warren, Martin J; Coutinho, Ana; Sousa, Filipa L; Fernandes, Fábio; Saraiva, Ligia M. "Control of heme homeostasis in Staphylococcus aureus". Paper presented in Gordon Research Conference on Cell Biology of Metals, 2019. Carvalho, Sandra Margarida; Kuipers, Oscar Paul; Saraiva, Ligia M. "Staphylococcus aureus a-acetolactate synthase ALS confers resistance to nitrosative stress imposed by host innate immunity". Paper presented in IV Genetics Workshop, Lisbon, Portugal, 2019. Videira, Marco André Moras; Lobo, Susana A.L; Silva, Liliana S.O; Warren, Martin J; Coutinho, Ana; Sousa, Filipa L; Fernandes, Fábio; Saraiva, Ligia M. "Staphylococcus aureus intracellular haem levels are controlled by a link between ferrochelatase and a haem monooxygenase enzyme". Paper presented in IV Genetics Workshop, 2019. Carvalho, Sandra Margarida; Saraiva, Ligia M. "Intracellular targets of the antimicrobial CORM-3 analyzed by NMR and Mass Spectrometry Metabolomics". Paper presented in Twin to illuminate metals in biology and biocatalysis through Biospectroscopy, TIMB3, kick-off meeting, Sintra, Portugal, 2018. Carvalho, Sandra Margarida; Freitas, CS; Kuipers OP; Saraiva, Ligia M. "Staphylococcus aureus metabolic strategies to survive nitrosative stress". Paper presented in 19th Biennial Meeting of Society for Free Radical Research International (SFRRI), Lisbon, Portugal., 2018. Carvalho, Sandra Margarida; Romão CC; Kuipers OP; Saraiva, Ligia M. "Insights into the action of carbon monoxide on Staphylococcus aureus". Paper presented in 3th International Conference Pathophysiology of Staphylococci, Tubingen, Germany, 2016. Videira, Marco A.M; Lobo, Susana A.L; Scott, Alan; Warren, Martin J; Saraiva, Ligia M. "Haem biosynthetic pathway in Staphylococcus aureus". Paper presented in 6th ITQB NOVA PhD Student´s Meeting, 2015. Carvalho, Sandra Margarida; Kuipers OP; Saraiva, Ligia M. "The effect of carbon monoxide on the human pathogen Staphylococcus aureus". Paper presented in Bacterial Electron Transfer Processes and Their Regulation, Vimeiro, Portugal., 2015.
Journal article	Saraiva, Ligia M; Liliana S. O. Silva; Lourenço, Frederico; Mafalda R. Almeida. Corresponding author: Saraiva, Ligia M. "Structural basis of Escherichia coli YtfE iron donor properties". Encyclopedia of Inorganic and Bioinorganic Chemistry (2023): In press Jordi Zamarreño Beas1, Marco A.M. Videira1, Val Karavaeva2, Frederico S. Lourenço1, Mafalda R. Almeida1, Filipa Sousa2, . Corresponding author: Jordi Zamarreño Beas1, Marco A.M. Videira1, Val Karavaeva2, Frederico S. Lourenço1, Mafalda R. Almeida1, Filipa Sousa2,. "In Campylobacter jejuni a new type of chaperone receives heme b from ferrochelatase". BIORXIV/2023/534706 (2023): Published Oliveira, Ana S.; Saraiva, Lígia M.; Carvalho, Sandra M.. "Staphylococcus epidermidis biofilms undergo metabolic and matrix remodeling under nitrosative stress". (2023): http://hdl.handle.net/10362/158524. https://doi.org/10.3389/fcimb.2023.1200923 Zamarreño Beas, Jordi; Videira, Marco A.M.; Karavaeva, Val; Lourenço, Frederico M.; Almeida, Mafalda R.; Sousa, Filipa; Saraiva, Lígia M.. "In Campylobacter jejuni, a new type of chaperone receives heme from ferrochelatase". (2023): http://hdl.handle.net/10362/158523. https://doi.org/10.3389/fgene.2023.1199357 Liliana S. O. Silva; Pedro M. Matias; Célia V. Romão; Lígia M. Saraiva. "Repair of Iron Center Proteins—A Different Class of Hemerythrin-like Proteins". Molecules 27 13 (2022): 4051-4051. https://doi.org/10.3390/molecules27134051. 10.3390/molecules27134051 Mendes, Sofia S.; Marques, Joana; Mesterházy, Edit; Straetener, Jan; Arts, Melina; Pissarro, Teresa; Reginold, Jorgina; et al. "Synergetic Antimicrobial Activity and Mechanism of Clotrimazole-Linked CO-Releasing Molecules". ACS Bio & Med Chem Au 2 4 (2022): 419-436. http://dx.doi.org/10.1021/acsbiomedchemau.2c00007. 10.1021/acsbiomedchemau.2c00007 Zamarreño Beas, Jordi; Videira, Marco A.M.; Saraiva, Lígia M.. "Regulation of bacterial haem biosynthesis". Coordination Chemistry Reviews 452 (2022): 214286. http://dx.doi.org/10.1016/j.ccr.2021.214286. 10.1016/j.ccr.2021.214286 Sandra M Carvalho; Cláudia S Freitas; Ana S Oliveira; Lígia M Saraiva. "Staphylococcus aureus flavohaemoglobin contributes to early stage biofilm development under nitrosative stress". FEMS Microbiology Letters 368 18 (2021): https://doi.org/10.1093/femsle/fnab131. 10.1093/femsle/fnab131 Sofia S. Mendes; Vanessa Miranda; Lígia M. Saraiva. "Hydrogen Sulfide and Carbon Monoxide Tolerance in Bacteria". Antioxidants (2021): https://doi.org/10.3390/antiox10050729. 10.3390/antiox10050729 Carvalho, Sandra M.; Freitas, Cláudia S.; Oliveira, Ana S.; Saraiva, Lígia M.. "Staphylococcus aureus flavohaemoglobin contributes to early stage biofilm development under nitrosative stress". (2021): http://hdl.handle.net/10362/142212. https://doi.org/10.1093/femsle/fnab131 Silva, Liliana S.O.; Matias, Pedro M.; Romão, Célia V.; Saraiva, Lígia M.. "Structural Basis of RICs Iron Donation for Iron-Sulfur Cluster Biogenesis". (2021): http://hdl.handle.net/10362/128785. https://doi.org/10.3389/fmicb.2021.670681 Apura, Patrícia; Saramago, Margarida; Peregrina, Alexandra; Viegas, Sandra C.; Carvalho, Sandra Margarida; Saraiva, Ligia M; Arraiano, Cecília M.; Domingues, Susana. Corresponding author: Domingues, Susana. "Tailor-made sRNAs: a plasmid tool to control the expression of target mRNAs in Pseudomonas putida". Plasmid 109 (2020): 102503. http://dx.doi.org/10.1016/j.plasmid.2020.102503. Published • 10.1016/j.plasmid.2020.102503 Apura, Patrícia; Saramago, Margarida; Peregrina, Alexandra; Viegas, Sandra C.; Carvalho, Sandra M.; Saraiva, Lígia M.; Arraiano, Cecília M.; Domingues, Susana. "Tailor-made sRNAs". (2020): http://hdl.handle.net/10362/128317. https://doi.org/10.1016/j.plasmid.2020.102503 Videira, Marco A.M.; Lobo, Susana A.L.; Sousa, Filipa L.; Saraiva, Lígia M.. "Identification of the sirohaem biosynthesis pathway in Staphylococcus aureus". (2020): http://hdl.handle.net/10362/91636. https://doi.org/10.1111/febs.15091 Marco A. M. Videira; Susana A. L. Lobo; Filipa L. Sousa; Lígia M. Saraiva. "Identification of the sirohaem biosynthesis pathway in Staphylococcus aureus". The FEBS Journal (2019): https://doi.org/10.1111/febs.15091. 10.1111/febs.15091 Borges, P.T.; Romão, C.V.; Saraiva, L.M.; Gonçalves, V.L.; Carrondo, M.A.; Teixeira, M.; Frazão, C.. "Analysis of a new flavodiiron core structural arrangement in Flv1-¿FlR protein from Synechocystis sp. PCC6803". Journal of Structural Biology 205 1 (2019): 91-102. http://www.scopus.com/inward/record.url?eid=2-s2.0-85057024169&partnerID=MN8TOARS. 10.1016/j.jsb.2018.11.004 Carvalho, Sandra M.; Marques, Joana; Romão, Carlos C.; Saraiva, Lígia M.. "Metabolomics of Escherichia coli Treated with the Antimicrobial Carbon Monoxide-Releasing Molecule CORM-3 Reveals Tricarboxylic Acid Cycle as Major Target". (2019): http://hdl.handle.net/10362/91639. https://doi.org/10.1128/AAC.00643-19 Carvalho, Sandra M.; Marques, Joana; Romão, Carlos C.; Saraiva, Lígia M.. "Metabolomics of Escherichia coli Treated with the Antimicrobial Carbon Monoxide-Releasing Molecule CORM-3 Reveals Tricarboxylic Acid Cycle as Major Target". (2019): http://hdl.handle.net/10362/91639. https://doi.org/10.1128/AAC.00643-19 Videira, M.A.M.; Lobo, S.A.L.; Silva, L.S.O.; Palmer, D.J.; Warren, M.J.; Prieto, M.; Coutinho, A.; et al. "Staphylococcus aureus haem biosynthesis and acquisition pathways are linked through haem monooxygenase IsdG". Molecular Microbiology 109 3 (2018): 385-400. http://www.scopus.com/inward/record.url?eid=2-s2.0-85052613393&partnerID=MN8TOARS. 10.1111/mmi.14060 Silva, L.S.O.; Baptista, J.M.; Batley, C.; Andrews, S.C.; Saraiva, L.M.; Silva, Liliana; Baptista, Joana; et al. "The di-iron RIC protein (YtfE) of Escherichia coli interacts with the DNA-binding protein from starved cells (Dps) to diminish RIC protein-mediated redox stress". Journal of Bacteriology 200 24 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85057192508&partnerID=MN8TOARS. 10.1128/JB.00527-18 Carvalho, Sandra M.; Kloosterman, Tomas G.; Manzoor, Irfan; Caldas, José; Vinga, Susana; Martinussen, Jan; Saraiva, Lígia M.; et al. "Interplay between capsule expression and uracil metabolism in Streptococcus pneumoniae D39". Frontiers in Microbiology 9 MAR (2018): http://www.scopus.com/inward/record.url?scp=85042932589&partnerID=8YFLogxK. https://doi.org/10.3389/fmicb.2018.00321 Silva, Liliana O.; Nobre, Lígia S.; Mil-Homens, Dalila; Fialho, Arsénio; Saraiva, Lígia M.; Molecular, Structural and Cellular Microbiology (MOSTMICRO); Instituto de Tecnologia Química e Biológica António Xavier (ITQB); et al. "Repair of Iron Centers RIC protein contributes to the virulence of Staphylococcus aureus". Virulence (2018): 1-6. http://www.scopus.com/inward/record.url?scp=85037664838&partnerID=8YFLogxK. https://www.tandfonline.com/doi/pdf/10.1080/21505594.2017.1389829?needAccess=true Lobo, S.A.L.; Videira, M.A.M.; Pacheco, I.; Wass, M.N.; Warren, M.J.; Teixeira, M.; Matias, P.M.; Romão, C.V.; Saraiva, L.M.. "Desulfovibrio vulgaris CbiK^Pcobaltochelatase: evolution of a haem binding protein orchestrated by the incorporation of two histidine residues". Environmental Microbiology 19 1 (2017): 106-118. http://www.scopus.com/inward/record.url?eid=2-s2.0-84983433234&partnerID=MN8TOARS. 10.1111/1462-2920.13479 Parente, M.R.; Forte, E.; Falabella, M.; Boneca, I.G.; Teixeira, M.; Giuffrè, A.; Saraiva, L.M.. "Nitrosative stress defences of the enterohepatic pathogenic bacterium Helicobacter pullorum". Scientific Reports 7 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85028543989&partnerID=MN8TOARS. 10.1038/s41598-017-10375-1 Carvalho, S.M.; de Jong, A.; Kloosterman, T.G.; Kuipers, O.P.; Saraiva, L.M.. "The Staphylococcus aureus a-acetolactate synthase ALS confers resistance to nitrosative stress". Frontiers in Microbiology 8 JUL (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85024120755&partnerID=MN8TOARS. 10.3389/fmicb.2017.01273 Flint, A.; Stintzi, A.; Saraiva, L.M.. "Oxidative and nitrosative stress defences of Helicobacter and Campylobacter species that counteract mammalian immunity". FEMS Microbiology Reviews 40 6 (2016): 938-960. http://www.scopus.com/inward/record.url?eid=2-s2.0-84994710554&partnerID=MN8TOARS. 10.1093/femsre/fuw025 Nobre, L.S.; Meloni, D.; Teixeira, M.; Viscogliosi, E.; Saraiva, L.M.. "Trichomonas vaginalis Repair of Iron Centres Proteins: The Different Role of Two Paralogs". Protist 167 3 (2016): 222-233. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964409718&partnerID=MN8TOARS. 10.1016/j.protis.2016.03.001 Parente, M.R.; Monteiro, J.T.; Martins, G.G.; Saraiva, L.M.. "Helicobacter pullorum induces nitric oxide release in murine macrophages that promotes phagocytosis and killing". Microbiology (United Kingdom) 162 3 (2016): 503-512. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961669799&partnerID=MN8TOARS. 10.1099/mic.0.000240 Nobre, L.S.; Jeremias, H.; Romão, C.C.; Saraiva, L.M.. "Examining the antimicrobial activity and toxicity to animal cells of different types of CO-releasing molecules". Dalton Transactions 45 4 (2016): 1455-1466. http://www.scopus.com/inward/record.url?eid=2-s2.0-84955447501&partnerID=MN8TOARS. 10.1039/c5dt02238j Nobre, L.S.; Lousa, D.; Pacheco, I.; Soares, C.M.; Teixeira, M.; Saraiva, L.M.. "Insights into the structure of the diiron site of RIC from Escherichia coli". FEBS Letters 589 4 (2015): 426-431. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964273503&partnerID=MN8TOARS. 10.1016/j.febslet.2014.12.028 Lobo, S.A.L.; Scott, A.; Videira, M.A.M.; Winpenny, D.; Gardner, M.; Palmer, M.J.; Schroeder, S.; et al. "Staphylococcus aureus haem biosynthesis: Characterisation of the enzymes involved in final steps of the pathway". Molecular Microbiology 97 3 (2015): 472-487. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937974827&partnerID=MN8TOARS. 10.1111/mmi.13041 Chaves-Ferreira, M.; Albuquerque, I.S.; Matak-Vinkovic, D.; Coelho, A.C.; Carvalho, S.M.; Saraiva, L.M.; Romão, C.C.; Bernardes, G.J.L.. "Spontaneous CO release from Ru^II(CO)2-protein complexes in aqueous solution, cells, and mice". Angewandte Chemie - International Edition 54 4 (2015): 1172-1175. http://www.scopus.com/inward/record.url?eid=2-s2.0-84921064821&partnerID=MN8TOARS. 10.1002/anie.201409344 Seixas, J.D.; Chaves-Ferreira, M.; Montes-Grajales, D.; Gonçalves, A.M.; Marques, A.R.; Saraiva, L.M.; Olivero-Verbel, J.; Romão, C.C.; Bernardes, G.J.L.. "An N-Acetyl Cysteine Ruthenium Tricarbonyl Conjugate Enables Simultaneous Release of CO and Ablation of Reactive Oxygen Species". Chemistry - A European Journal 21 42 (2015): 14708-14712. http://www.scopus.com/inward/record.url?eid=2-s2.0-84943449535&partnerID=MN8TOARS. 10.1002/chem.201502474 Pinto, A.F.; Romão, C.V.; Pinto, L.C.; Huber, H.; Saraiva, L.M.; Todorovic, S.; Cabelli, D.; Teixeira, M.. "Superoxide reduction by a superoxide reductase lacking the highly conserved lysine residue". Journal of Biological Inorganic Chemistry 20 1 (2015): 155-164. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925507271&partnerID=MN8TOARS. 10.1007/s00775-014-1222-6 Saraiva, Ana Laura; Payan-Carreira, Rita; Gärtner, Fátima; Fortuna da Cunha, Marta R.; Rêma, Alexandra; Faria, Fátima; Lourenço, Lígia M.; Pires, Maria dos Anjos. "An immunohistochemical study on the expression of sex steroid receptors, Ki-67 and cytokeratins 7 and 20 in feline endometrial adenocarcinomas". (2015): http://hdl.handle.net/10348/4831. Zappi,Daniela C.; Filardi,Fabiana L. Ranzato; Leitman,Paula; Souza,Vinícius C.; Walter,Bruno M.T.; Pirani,José R.; Morim,Marli P.; et al. "Growing knowledge: an overview of Seed Plant diversity in Brazil". (2015): http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2175-78602015000401085. Chaves-Ferreira, Miguel; Albuquerque, Inês S.; Matak-Vinkovic, Dijana; Coelho, Ana C.; Carvalho, Sandra M.; Saraiva, Lígia M.; Romão, Carlos C.; Bernardes, Gonçalo J. L.. "Spontaneous CO release from RuII(CO)2-protein complexes in aqueous solution, cells, and mice". (2015): http://hdl.handle.net/10451/51756. 10.1002/anie.201409344 Loureiro, Ana; Abreu, Ana S.; Sárria, M. P.; Figueiredo, Mafalda C. O.; Saraiva, Lígia M.; Bernardes, Gonçalo J. L.; Gomes, Andreia; Paulo, Artur Cavaco. "Functionalized protein nanoemulsions by incorporation of chemically modified BSA". (2015): http://hdl.handle.net/1822/34795. 10.1039/C4RA13802C Justino, M.C.; Parente, M.R.; Boneca, I.G.; Saraiva, L.M.. "FrxA is an S-nitrosoglutathione reductase enzyme that contributes to Helicobacter pylori pathogenicity". FEBS Journal 281 19 (2014): 4495-4505. http://www.scopus.com/inward/record.url?eid=2-s2.0-84912117623&partnerID=MN8TOARS. 10.1111/febs.12958 Nobre, L.S.; Saraiva, L.M.. "Role of the siderophore transporter SirABC in the Staphylococcus aureus resistance to oxidative stress". 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"Functional Characterization of Peroxiredoxins from the Human Protozoan Parasite Giardia intestinalis". PLoS Neglected Tropical Diseases 8 1 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84893796588&partnerID=MN8TOARS. 10.1371/journal.pntd.0002631 Palmer, D.J.; Schroeder, S.; Lawrence, A.D.; Deery, E.; Lobo, S.A.; Saraiva, L.M.; Mclean, K.J.; et al. "The structure, function and properties of sirohaem decarboxylase - an enzyme with structural homology to a transcription factor family that is part of the alternative haem biosynthesis pathway". Molecular Microbiology 93 2 (2014): 247-261. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904061123&partnerID=MN8TOARS. 10.1111/mmi.12656 Nobre, Lígia S.; Garcia-Serres, Ricardo; Todorovic, Smilja; Hildebrandt, Peter; Teixeira, Miguel; Latour, Jean Marc; Saraiva, Lígia M.. "Escherichia coli RIC is able to donate iron to iron-sulfur clusters". (2014): http://hdl.handle.net/10362/93031. https://doi.org/10.1371/journal.pone.0095222 Nobre, L.S.; Saraiva, L.M.. "Effect of combined oxidative and nitrosative stresses on Staphylococcus aureus transcriptome". Applied Microbiology and Biotechnology 97 6 (2013): 2563-2573. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878846133&partnerID=MN8TOARS. 10.1007/s00253-013-4730-3 Venceslau, S.S.; Cort, J.R.; Baker, E.S.; Chu, R.K.; Robinson, E.W.; Dahl, C.; Saraiva, L.M.; Pereira, I.A.C.. "Redox states of desulfovibrio vulgaris dsrC, a key protein in dissimilatory sulfite reduction". Biochemical and Biophysical Research Communications 441 4 (2013): 732-736. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888818405&partnerID=MN8TOARS. 10.1016/j.bbrc.2013.10.116 Figueiredo, M.C.O.; Lobo, S.A.L.; Sousa, S.H.; Pereira, F.P.; Wall, J.D.; Nobre, L.S.; Saraiva, L.M.. "Hybrid Cluster Proteins and Flavodiiron Proteins Afford Protection to Desulfovibrio vulgaris upon Macrophage Infection". Journal of Bacteriology 195 11 (2013): 2684-2690. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877961659&partnerID=MN8TOARS. 10.1128/JB.00074-13 Tavares, A.F.; Parente, M.R.; Justino, M.C.; Oleastro, M.; Nobre, L.S.; Saraiva, L.M.. "The bactericidal activity of carbon monoxide-releasing molecules against helicobacter pylori". PLoS ONE 8 12 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84891332779&partnerID=MN8TOARS. 10.1371/journal.pone.0083157 Figueiredo, M.C.O.; Lobo, S.A.L.; Carita, J.N.; Nobre, L.S.; Saraiva, L.M.. "Bacterioferritin protects the anaerobe Desulfovibrio vulgaris Hildenborough against oxygen". Anaerobe 18 4 (2012): 454-458. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864331590&partnerID=MN8TOARS. 10.1016/j.anaerobe.2012.06.001 Baptista, J.M.; Justino, M.C.; Melo, A.M.P.; Teixeira, M.; Saraiva, L.M.. 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Biochimica et Biophysica Acta - Gene Structure and Expression 1520 1 (2001): 63-70. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035973869&partnerID=MN8TOARS. 10.1016/S0167-4781(01)00250-0 Matias, P.M.; Soares, C.M.; Saraiva, L.M.; Coelho, R.; Morais, J.; Le Gall, J.; Carrondo, M.A.. "[NiFe] hydrogenase from Desulfovibrio desulfuricans ATCC 27774: Gene sequencing, three-dimensional structure determination and refinement at 1.8 Å and modelling studies of its interaction with the tetrahaem cytochrome c3". Journal of Biological Inorganic Chemistry 6 1 (2001): 63-81. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034846760&partnerID=MN8TOARS. 10.1007/s007750000167 Valente, F.M.A.; Saraiva, L.M.; LeGall, J.; Xavier, A.V.; Teixeira, M.; Pereira, I.A.C.. "A membrane-bound cytochrome c3: A type II cytochrome c3from desulfovibrio vulgaris hildenborough". ChemBioChem 2 12 (2001): 895-905. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035804166&partnerID=MN8TOARS. 10.1002/1439-7633(20011203)2:12<895::AID-CBIC895>3.0.CO;2-V Miramar, M.D.; Costantini, P.; Ravagnan, L.; Saraiva, L.M.; Haouzi, D.; Brothers, G.; Penninger, J.M.; et al. "NADH Oxidase Activity of Mitochondrial Apoptosis-inducing Factor". Journal of Biological Chemistry 276 19 (2001): 16391-16398. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035844170&partnerID=MN8TOARS. 10.1074/jbc.M010498200 Abreu, I.A.; Saraiva, L.M.; Soares, C.M.; Teixeira, M.; Cabelli, D.E.. "The Mechanism of Superoxide Scavenging by Archaeoglobus fulgidus Neelaredoxin". Journal of Biological Chemistry 276 42 (2001): 38995-39001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035914396&partnerID=MN8TOARS. 10.1074/jbc.M103232200 Abreu, I.A.; Saraiva, L.M.; Carita, J.; Huber, H.; Stetter, K.O.; Cabelli, D.; Teixeira, M.. "Oxygen detoxification in the strict anaerobic archaeon Archaeoglobus fulgidus: Superoxide scavenging by Neelaredoxin". Molecular Microbiology 38 2 (2000): 322-334. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033752865&partnerID=MN8TOARS. 10.1046/j.1365-2958.2000.02121.x Da Costa, P.N.; Conte, C.; Saraiva, L.M.. "Expression of a Desulfovibrio tetraheme cytochrome c in Escherichia coli". Biochemical and Biophysical Research Communications 268 3 (2000): 688-691. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034708064&partnerID=MN8TOARS. 10.1006/bbrc.2000.2198 Da Costa, P.N.; Marujo, P.E.; Van Dongen, W.M.A.M.; Arraiano, C.M.; Saraiva, L.M.. "Cloning, sequencing and expression of the tetraheme cytochrome c3from Desulfovibrio gigas". Biochimica et Biophysica Acta - Gene Structure and Expression 1492 1 (2000): 271-275. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034697735&partnerID=MN8TOARS. 10.1016/S0167-4781(00)00099-3 Bes, M.T.; Parisini, E.; Inda, L.A.; Saraiva, L.M.; Peleato, M.L.; Sheldrick, G.M.. "Crystal structure determination at 1.4 Å resolution of ferredoxin from the green alga Chlorella fusca". Structure 7 10 (1999): 1201-1211. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033570020&partnerID=MN8TOARS. 10.1016/S0969-2126(00)80054-4 Matias, P.M.; Saraiva, L.M.; Soares, C.M.; Coelho, A.V.; LeGall, J.; Carrondo, M.A.. "Nine-haem cytochrome c from Desulfovibrio desulfuricans ATCC 27774: Primary sequence determination, crystallographic refinement at 1.8 and modelling studies of its interaction with the tetrahaem cytochrome c3". Journal of Biological Inorganic Chemistry 4 4 (1999): 478-494. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032836538&partnerID=MN8TOARS. 10.1007/s007750050334 Saraiva, L.M.; Da Costa, P.N.; Legall, J.. "Sequencing the gene encoding Desulfovibrio desulfuricans ATCC 27774 nine-heme cytochrome c". Biochemical and Biophysical Research Communications 262 3 (1999): 629-634. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033533408&partnerID=MN8TOARS. 10.1006/bbrc.1999.1238 Saraiva, L.M.; Salgueiro, C.A.; Da Costa, P.N.; Messias, A.C.; LeGall, J.; Van Dongen, W.M.A.M.; Xavier, A.V.. "Replacement of lysine 45 by uncharged residues modulates the redox-Bohr effect in tetraheme cytochrome c3of Desulfovibrio vulgaris (Hildenborough)". Biochemistry 37 35 (1998): 12160-12165. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032169524&partnerID=MN8TOARS. 10.1021/bi981001v Inda, L.A.; Medina, M.; Saraiva, L.M.; Gómez-Moreno, C.; Teixeira, M.; Peleato, M.L.. "Characterisation of cytochrome c6from Chlorella fusca". Photosynthesis Research 54 2 (1997): 107-114. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031468021&partnerID=MN8TOARS. 10.1023/A:1005955201482 Saraiva, L.M.; Salgueiro, C.A.; LeGall, J.; Van Dongen, W.M.A.M.; Xavier, A.V.. "Site-directed mutagenesis of a phenylalanine residue strictly conserved in cytochromes c3". Journal of Biological Inorganic Chemistry 1 6 (1996): 542-550. http://www.scopus.com/inward/record.url?eid=2-s2.0-0000069739&partnerID=MN8TOARS. Saraiva, L.M.; Besson, S.; Moura, I.; Fauque, G.. "Purification and preliminary characterization of three c-type cytochromes from pseudomonas nautica strain 617". Biochemical and Biophysical Research Communications 212 3 (1995): 1088-1097. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029088401&partnerID=MN8TOARS. 10.1006/bbrc.1995.2081 Saraiva, L.M.; Besson, S.; Fauque, G.; Moura, I.. "Characterization of the dihemic cytochrome C549from the marine denitrifying bacterium pseudomonas nautica 617". Biochemical and Biophysical Research Communications 199 3 (1994): 1289-1296. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028291355&partnerID=MN8TOARS. 10.1006/bbrc.1994.1371 Saraiva, L.M.; Thomson, A.J.; Lebrun, N.E.; Liu, M.Y.; Payne, W.J.; Legall, J.; Moura, I.. "Replacement of Methionine as the Axial Ligand of Achromobacter cycloclastes Cytochrome C554at High pH Values Revealed by Absorption, EPR and MCD Spectroscopy". Biochemical and Biophysical Research Communications 204 1 (1994): 120-128. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028019788&partnerID=MN8TOARS. 10.1006/bbrc.1994.2434 Saraiva, L.M.; Fauque, G.; Besson, S.; Moura, I.. "Physico-chemical and Spectroscopic Properties of the Monohemic Cytochrome C552 from Pseudomonas nautica 617". European Journal of Biochemistry 224 3 (1994): 1011-1017. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028050131&partnerID=MN8TOARS. 10.1111/j.1432-1033.1994.01011.x SARAIVA, L.M.; DENARIAZ, G.; LIU, M.-Y.; PAYNE, W.J.; Le GALL, J.; MOURA, I.. "NMR and EPR studies on a monoheme cytochrome c550isolated from Bacillus halodenitrificans". European Journal of Biochemistry 204 3 (1992): 1131-1139. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026520032&partnerID=MN8TOARS. 10.1111/j.1432-1033.1992.tb16738.x SARAIVA, L.M.; LIU, M.Y.; PAYNE, W.J.; LEGALL, J.; MOURA, J.J.G.; MOURA, I.. "Spin-equilibrium and heme-ligand alteration in a high-potential monoheme cytochrome (cytochrome c554) from Achromobacter cycloclastes, a denitrifying organism". European Journal of Biochemistry 189 2 (1990): 333-341. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025264922&partnerID=MN8TOARS. 10.1111/j.1432-1033.1990.tb15494.x
Preprint	Jordi Zamarreño Beas; Marco A.M. Videira; Val Karavaeva; Frederico S. Lourenço; Mafalda R. Almeida; Filipa Sousa; Lígia M. Saraiva. "InCampylobacter jejunia new type of chaperone receives hemebfrom ferrochelatase". 2023. https://doi.org/10.1101/2023.03.30.534706. 10.1101/2023.03.30.534706
Thesis / Dissertation	Oliveira, Ana Rita Santos. "Understanding how Staphylococcus epidermidis adapts to nitrosative stress generated by the cells of innate immunity". Master, 2021. http://hdl.handle.net/10362/111471. Oliveira, Ana Rita Santos. "Understanding how Staphylococcus epidermidis adapts to nitrosative stress generated by the cells of innate immunity". Master, 2021. http://hdl.handle.net/10362/111471. Amorim, André Ricardo Barreiro. "Influence of the nir operon in the adaptation of Staphylococcus aureus to the host environment". Master, 2019. http://hdl.handle.net/10773/27763. Videira, Marco A.M. "Staphylococcus aureus: the paths and crosstalks that lead to heme". PhD, 2018. http://hdl.handle.net/10362/93875. Parente, Adelina Margarida Lima Pereira Rodrigues. "Defences of Helicobacter species against host antimicrobials". PhD, 2016. http://hdl.handle.net/10362/51886. Santos, Inês Henriques dos. "Estudo do regulador SrrAB do Staphylococcus aureus". Master, 2014. http://hdl.handle.net/10451/15787. Santos, Inês Henriques dos. "Estudo do regulador SrrAB do Staphylococcus aureus". Master, 2014. http://hdl.handle.net/10451/15787. Figueiredo, Mafalda Cristina de Oliveira. "Desulfovibrio vulgaris defenses against oxidative and nitrosative stresses". PhD, 2013. http://hdl.handle.net/10362/10883. Tavares, Ana Filipa Nogueira. "Novel insights into the action of antimicrobial agents against human pathogens". PhD, 2013. http://hdl.handle.net/10362/11965. Ribeiro, Cláudia Azevedo, 1988-. "Estudo da utilização do hemo em Staphilococcus aureus". Master, 2013. http://hdl.handle.net/10451/9443. Figueiredo, Mafalda Cristina de Oliveira. "Desulfovibrio vulgaris defenses against oxidative and nitrosative stresses". PhD, 2013. http://hdl.handle.net/10362/10883. Godinho, Catarina Sofia Caetano. "Estudo do gene ric de staphylococcus aureus". Master, 2012. http://hdl.handle.net/10451/9273. Baptista, Joana Morais. "The role of Di-iron proteins in pathogen resistance". PhD, 2012. http://hdl.handle.net/10362/8583. Godinho, Catarina Sofia Caetano. "Estudo do gene ric de staphylococcus aureus". Master, 2012. http://hdl.handle.net/10451/9273. Godinho, Catarina Sofia Caetano. "Estudo do gene ric de staphylococcus aureus". Master, 2012. http://hdl.handle.net/10451/9273. Pereira, Fábio Alexandre Paulino; Sobral, Luís Miguel da Silva. "Estudo das "Hybrid Cluster Proteins" de Desulfovibrio vulgaris Hildenborough". Master, 2012. http://hdl.handle.net/10451/8886. Venceslau, Sofia Cristina dos Santos. "Electron transfer chains in sulfate reducing bacteria". PhD, 2011. http://hdl.handle.net/10362/9779. Nobre, Lígia S.. "Unravelling novel modes of antimicrobial action". PhD, 2010. http://hdl.handle.net/10362/5156. Lobo, Susana André. "Anaerobic bacteria: an investigation of metabolic important enzymes: a novel type of oxygen reductase and enzymes of the tetrapyrrole biosynthesis". PhD, 2009. http://hdl.handle.net/10362/4082.

Intellectual property

Patent

Saraiva, Ligia. 2018. "Lígia S. Nobre, Joao Seixas, Carlos Romão, and Lígia M. Saraiva. (2008) Treatment of infections by carbon monoxide. International A". United States.
Expired

Other

Other output

A formação docente na perspectiva da inclusão: Científico. Made available in DSpace on 2016-06-28T17:32:45Z (GMT). No. of bitstreams: 0 Previous issue date: 2007. Added 1 bitstream(s) on 2016-06-28T17:40:31Z : No. of bitstreams: 1 ISBN9788561134006-2007-1-179.pdf: 768230 bytes, checksum: 0e3191a9bd075639741b928fa759fb67 (MD5). Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Universidade Federal de São Carlos (UFSCar), Centro de Educação e C. 2016. Veltrone, Aline Aparecida; Mendes, Enicéia Gonçalves; Saraiva, Ana Cláudia Lopes Chequer; Vicente, Carla Cristina; Ferenc, Alvanize Valente Fernandes; Rossi, Célia Regina [UNESP]; Pedroso, Cristina Cinto Araújo; et al. http://hdl.handle.net/11449/140051.
Functionalized protein nanoemulsions by incorporation of chemically modified BSA. The incorporation of bioactive compounds in stealth nanoparticles or nanoemulsions enhances their half-life in systemic circulation and can overcome the problems associated with the free drug. Bovine serum albumin (BSA)-drug conjugates were produced with either methotrexate (MTX), a potent anticancer agent, or vancomycin (VCM), a potent antibiotic. Those conjugates were used to produce functionali. 2015. Loureiro, Ana; Abreu, Ana S.; Sárria, M. P.; Figueiredo, Mafalda C. O.; Saraiva, Lígia M.; Bernardes, Gonçalo J. L.; Gomes, Andreia; Paulo, Artur Cavaco. http://hdl.handle.net/1822/34795.
10.1039/C4RA13802C

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2006/01/01	40 oral presentations at International meetings . Poster presentation 185 in national and international meetings.

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2004/01/01 - Current	Supervision of 12 Postdocs- 2 ongoing. Supervision of 12 PhD (see PhD thesis) - 2 ongoing. Supervision 27 Master students - 2 ongoing Supervisor

Committee member

	Activity description Role	Institution / Organization
2022 - Current	General Council of UNL Member	Universidade Nova de Lisboa, Portugal
2020 - Current	Ethical Committee of IHMT-ITQB-Nova-IGC
2019/01/01 - Current	ITQB representative in NovaPrecision da NovaSaúde working Group. UNL Member	Universidade Nova de Lisboa, Portugal
2014/01/01 - Current	Coordinator of Gene Expression and Stress Survival of ITQB MOSTMICRO (Molecular, Structural and Cellular Microbiology ) Unit Coordinator	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2018/01/01 - 2023	Coordinator of Chronic Disease and Infection Group of NovaSaúde, UNL Coordinator	Universidade Nova de Lisboa, Portugal
2018 - 2021	General Council Member	Universidade Nova de Lisboa, Portugal

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2019/09/01 - Current	Medical Microbiology - Coordinator	Biochemistry for Health Master FCT-ITQB-NOVA (Mestrado)	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2014/03/01 - 2023	Molecular Basis of Disease Coordinator	Biochemistry for Health Master FCT-ITQB-NOVA (Mestrado)	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal

Evaluation committee

	Activity description Role	Institution / Organization	Funding entity
2012/01/01 - Current	Grant Evaluator of :Fonds de la Recherche Scientifique. Belgium. Austrian Science Foundation, Fundo Regional para a Ciência e Tecnologia, Açores. Agence Nationale de la Recherche. France. Fundação para a Ciência e Tecnologia, Portugal. Biotechnology and Biological Sciences Research Council, United Kindgom. British Society for Antimicrobial Therapy. Vice- Chair and Chair of Marie Sklodowska-Curie Individual Fellowships and Spreading Excellence and Widening participation (since 2014)

Journal scientific committee

	Journal title (ISSN)	Publisher
2021 - Current	Frontiers in Cellular and Infection Microbiology Editorial Board	Frontiers
2017/01/01 - Current	Frontiers in Microbiology Editorial Board (1664-302X)	Frontiers Media SA
2012/01/01 - Current	FEMS Microbiology Letters Editorial Board (1574-6968)	Oxford University Press
2012/01/01 - Current	PLoS ONE Editorial Board (1932-6203)	Public Library of Science
2012/01/01 - Current	The Open Microbiology Journal Editorial Board (1874-2858)	Bentham Science

Distinctions

Award

2023	Women in Science 2023 Ciência Viva, Portugal