Margarida Maria F. B. e Silva is an Assistant Professor at the University of Lisbon (UL)-Faculty of Pharmacy and a Researcher at the Research Institute for Medicines (iMed.ULisboa / Metabolism, Genetics and Proteins group), a R&D Unit at the University of Lisbon. She graduated in Pharmaceutical Sciences and obtained a Ph.D. in Pharmacy (Biochemistry) in 2002 from UL. Principal investigator and team member of several projects funded by FCT and other sources. Research work has been focused on elucidating genetic/molecular determinants of drug interactions with endogenous metabolism. Relevant scientific publications unveiled novel insights on mitochondrial bioenergetics underlying pharmacological or toxicological effects induced by drugs. She supervised various Doctoral fellows (concluded) and Master's students. Received four scientific merit awards. Published ca. one hundred indexed peer-reviewed publications in specialized journals and interacted with ca. 100 collaborators as co-authorship of scientific papers. Ongoing projects have explored metabolism-driven questions with proteomic or genomic mechanistic links, under a Translational Biochemistry perspective (Medical and Health Sciences). She specialized in advanced analytical techniques of mass spectrometry-based metabolomics for studying small molecules as biomarkers of disease and inherent pathophysiological mechanisms. Investigational methods using targeted metabolomics were developed and validated for the study of Inherited Metabolic Disorders (IMD) in Portugal. Current projects intersect the study of IMD with the role of metabolites in pathogenesis and respective intra- or intercellular communication within the liver-gut-brain axis.