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Liliana Sofia Meireles da Costa has completed her bachelor degree in Genetics and Biotechnology in 2014 at the Universidade de Trás-os-Montes e Alto Douro in. She then obtained her master degree in Biotechnology for the Health Sciences in 2017, in the same institution. During her academic course, she had the opportunity to get in touch with several different areas and techniques of research such as genetics, molecular and cell biology. She had also worked abroad in the Wellcome Trust Sanger Institute (UK) were she was able to map for the first time the Y chromosome of a gibbon species by using fluorescent in situ hybridization. Throughout this work she was able to acknowledge the importance of model systems and biomedical studies for therapeutics research. Currently she is a PhD student at ICVS, University of Minho, searching for nuclear ataxin-3 protein-protein interactions as therapeutic targets in Machado-Joseph disease. She is interested in the field of neurosciences in general and more particularly in neurodegenerative diseases and the physiological function of the disease-proteins, as a way of better understand the pathological mechanisms underlying neurodegeneration, which may contribute for development of more efficient therapeutic strategies.
Identification

Personal identification

Full name
Liliana Sofia Meireles da Costa

Citation names

  • Meireles-Costa L

Author identifiers

Ciência ID
8011-BA38-129D

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Genetics and Heredity

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Advanced (C1) Advanced (C1) Intermediate (B1)
Portuguese (Mother tongue)
Education
Degree Classification
2019/12/01 - 2023/12/01
Ongoing
Health Sciences (Doctor)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2014/09/12 - 2017
Concluded
Biotechnology for the Health Sciences (Master)
Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
"A Y-chromosome map between the gibbon Nomascus leucogenys and Humans: Evolutionary inferences and biomedical applications" (THESIS/DISSERTATION)
16/20
2010/09/10 - 2014
Concluded
Genetics and Biotechnology (Bachelor)
Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
"Genotoxic effect of artificial sweeteners in Drosophila melanogaster's neuroblasts;" (THESIS/DISSERTATION)
13/20
Affiliation

Science

Category
Host institution
Employer
2018/11/27 - 2019/11/26 Research Assistant (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2016/04/01 - 2017/11/15 Research Trainee (Research) Universidade de Trás-os-Montes e Alto Douro, Portugal
2015/11/01 - 2016/03/04 Research Trainee (Research) The Wellcome Trust Sanger Institute, United Kingdom
2014/02/01 - 2014/07/01 Research Trainee (Research) Universidade de Trás-os-Montes e Alto Douro, Portugal
Projects

Grant

Designation Funders
2018/11/27 - 2019/11/26 Nuclear ataxin-3 protein-protein interactions as therapeutic targets in Machado-Joseph disease
POCI-01-0145-FEDER-029056
Research Fellow
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Fundação para a Ciência e a Tecnologia, Portugal
Ongoing
Outputs

Publications

Conference poster
  1. Meireles-Costa L; Neves-Carvalho, Andreia; Almeida B; Teixeira-Castro, Andreia; Maciel, Patrícia. Corresponding author: Maciel, Patrícia. "Nuclear ATXN3 DUB Physiological Substrates: Towards Understanding Their Role In The Context Of Machado-Joseph Disease". Paper presented in Federation of European Neuroscience Societies (FENS2022), 2022.
  2. Meireles-Costa L. "A comparative Y-chromosome map between the gibbon Nomascus leucogenys and humans". Paper presented in XL Jornadas Portuguesas de Genética, 2016.
  3. Meireles-Costa L. "Disclosing the Satellite DNA pattern in the gibbon Nomascus leucogenys Y chromosome". Paper presented in XL Jornadas Portuguesas de Genética, 2016.
  4. Meireles-Costa L. "Genotoxic effect of artificial sweeteners in Drosophila melanogaster neuroblasts". Paper presented in VII Congress of Biology at Universidade de Trás-os-Montes e Alto Douro., 2014.
Thesis / Dissertation
  1. Meireles-Costa L. "A Y-chromosome map between the gibbon Nomascus leucogenys and Humans: Evolutionary inferences and biomedical applications". Master, The Wellcome Trust Sanger Institute, 2017. http://hdl.handle.net/10348/8749.
  2. Meireles-Costa L. "Genotoxic effect of artificial sweeteners in Drosophila melanogaster neuroblasts". Degree, Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, 2014.
Activities

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2021/04/01 - 2021/06/30 Characterization of ataxin-3 nuclear interactors: towards understanding their role in the context of Machado-Joseph Disease
Co-supervisor of Ana Rita Silva Reis Dourado
Applied Biology (Degree)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2021/04/01 - 2021/06/30 Development of a protein-protein interaction assay for screening of Machado-Joseph Disease Modifiers
Co-supervisor of João Gonçalo Ereira da Silva
Applied Biology (Degree)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Event organisation

Event name
Type of event (Role)
Institution / Organization
2013/02/20 - 2013/02/22 V National Congress of Genetics and Biotechnology (2013/02/20 - 2013/02/22)
Congress (Co-organisor)
Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2016/06/02 - 2016/06/03 XL National Congress of Genetics
Congress
Universidade de Coimbra, Portugal
2014/03/06 - 2014/03/09 VI National Congress of Genetic and Biotechnology
Congress
Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2012/11/14 - 2012/11/14 I Seminar of Neurosciences
Seminar
Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2012/03/01 - 2012/03/03 IV National Congress of Genetics and Biotechnology
Congress
Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2012/02/15 - 2012/02/15 I Seminar of Bioinformatics
Seminar
Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2011/02/16 - 2011/02/18 III National Congress of Genetics and Biotechnology
Congress
Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal

Association member

Society Organization name Role
2012/04/12 - 2013/04/09 ADNGB - Genetics and Biotechnology Students Association Secretary

Mentoring / Tutoring

Topic Student name
2021/09/01 - 2022/12/15 Development of a cellular ataxin-3 protein-protein interaction (PPI) assay for high-throughput screening of PPI modifiers Ana Rita Ferreira Fernades
2019/04/01 - 2019/07/01 Study of the phisyological relevance of the interaction ataxina-3:HSP60 in neuronal cells Catarina Ferreira