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Identification

Personal identification

Full name
Maria Carmen Alpoim

Citation names

  • Alpoim, Maria

Author identifiers

Ciência ID
7A1F-13F5-19A8
ORCID iD
0000-0001-7273-9371
Education
Degree Classification
1977/01/15 - 1980/07/02
Concluded
 PhD (Doktor (PhD))
Major in Química Orgânica
Imperial College Department of Chemistry, United Kingdom
"The Diaxial Diequatorial Rearragments in Steroidal Dibromides" (THESIS/DISSERTATION)
 NA
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2010/11/02 - 2020/04 Associate Professor (University Teacher) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2005/05/01 - 2010/10/31 Associate Professor (University Teacher) Universidade de Coimbra Departamento de Bioquímica, Portugal
Universidade de Coimbra, Portugal
1994/09/01 - 2005/04/30 Assistant Professor (University Teacher) Universidade de Coimbra Departamento de Bioquímica, Portugal
1981/03/01 - 1994/09/01 Assistant Professor (University Teacher) Universidade de Coimbra Departamento de Química, Portugal
1973/05/02 - 1981/02/01 Assistant (University Teacher) Universidade de Coimbra- FCTUC Departamento de Química, Portugal
Universidade de Coimbra Departamento de Química, Portugal

Positions / Appointments

Category
Host institution 		Employer
2009/01/02 - 2010/10/31 President Universidade de Coimbra Departamento de Bioquímica, Portugal
Projects

Grant

Designation Funders
2013/05 - 2015/09 Cancer stem cells and tumor progression: from molecular mechanisms to clinical consequences
grant.Provided by PTCRIS: 128214
 Fundação para a Ciência e a Tecnologia
2007/01 - 2010/01 Development of a Cellular System for the Study of Cr(VI)-induced Lung Carcinogenesis.
CIMAGO 16/06
 CIMAGO
2007/01 - 2009/12 ASensor- small and robust tool for arsenic environmental monitoring
grant.Provided by PTCRIS: 82468
 Fundação para a Ciência e a Tecnologia
2004/02 - 2008/01 Cr(VI)-INDUCED GENOTOXIC STRESS: THE SIGNALLING MECHANISMS THAT LINK CELL CYCLE AND CELL FATE –
POCTI/CBO/48631/2002
 Fundação para a Ciência e Tecnologia
2006/01 - 2007/12 ASensor- small and robust tool for arsenic environmental monitoring
grant.Provided by PTCRIS: 60909
 Fundação para a Ciência e a Tecnologia
2002/03 - 2006/01 INDEGENOUS BACTERIA ADAPTED TO METAL POLLUTED ENVIRONMENT AS SAFETY TOOLS IN MONITIROZATION AND BIOREMEDIATION"–
POCTI/42414/BSE/2001
 Fundação para a Ciência e Tecnologia
1999/05 - 2003/05 BACTERIA ADAPTED TO CHROMIUM POLLUTED BIOTOPES" -
PRAXIS/P/BIA/13166/1998
 Fundação para a Ciência e Tecnologia

Contract

Designation Funders
2016/01 - 2018/12 Red2Discovery - As macroalgas vermelhas Sphoerococcus Coronopifolius e Asparagopsis armata como alvos para a descoberta de novos fármacos de origem marinha
FEDER 16791
 Horizon 2020 Framework Programme
Outputs

Publications

Book
  1. Alpoim, Maria. Heat Shock Protein 90 in Human Diseases and Disorders. Switzerland. 2019.
    10.1007/978-3-030-23158-3
Book chapter
  1. Alpoim, Maria. "DNA damage, repair and misrepair in cancer and in cancer therapy.". Czech Republic, 2011.
    10.5772/23190
  2. Alpoim, Maria. "Hexavalent chromium exposure, genomic instability and lung cancer.". Greece, 2008.
Conference paper
  1. Alpoim, Maria. "Cancer stem cells and dedifferentiation: the stromal match-point!.". 2013.
    10.1158/1538-7445.AM2013-2603
  2. Alpoim, Maria. "Senescent bronchial fibroblasts drive bronchial epithelial cells metaplasic transformation following exposure to hexavalent chromium.". 2012.
    doi/10.1111/j.1742-4658.2010.08705.x/pdf
  3. Alpoim, Maria. "On the origin of cancer stem cells.". 2012.
  4. Alpoim, Maria. "On the origin of cancer stem cells.". 2012.
  5. Alpoim, Maria. "Hexavalent chromium, cancer stem cells and dedifferentiation.". 2012.
  6. Alpoim, Maria. "Hexavalent chromium, cancer stem cells and dedifferentiation.". 2012.
  7. Alpoim, Maria. "Cancer stem cells and dedifferentiation: Implications in lung cancer.". 2011.
    10.1111/j.1742-4658.2011.08137.x/pdf
  8. Alpoim, Maria. "Metabolic changes in human bronchial epithelial cells upon chronic exposure to hexavalent chromium.". 2010.
  9. Alpoim, Maria. "Cr(VI)-induced malignant transformation of a bronchial epithelial cell line association with altered mitochondria and bioenergetic phenotypes.". 2010.
  10. Alpoim, Maria. "Metabolic changes in human bronchial epithelial cells upon chronic exposure to hexavalent chromium.". 2010.
  11. Alpoim, Maria. "Cr(VI)-induced malignant transformation of a bronchial epithelial cell line association with altered mitochondria and bioenergetic phenotypes.". 2010.
  12. Alpoim, Maria. "Malignant transformation of human bronchial epithelial cells (BEAS-2B) by Cr(VI) is associated with altered mitochondria and bioenergetic phenotype.". 2010.
    doi/10.1111/j.1742-4658.2010.07680.x/abstract
  13. Alpoim, Maria. "Hexavalent chromium and lung cancer: new perspectives!". 2009.
    10.1111/j.1742-4658.2009.07051.x
  14. Alpoim, Maria. "Clastogenic effects of hexavalent chromium in a human bronchial epithelial cell line.". 2008.
    10.1111/j.1742-4658.2008.06448.x
Journal article
  1. Alves, Celso; Silva, Joana; Pinteus, Susete; Alonso, Eva; Alvariño, Rebeca; Duarte, Adriana; Marmitt, Diorge; et al. "Cytotoxic Mechanism of Sphaerodactylomelol, an Uncommon Bromoditerpene Isolated from Sphaerococcus coronopifolius". Molecules 26 5 (2021): 1374. http://dx.doi.org/10.3390/molecules26051374.
    Published • 10.3390/molecules26051374
  2. Alpoim, Maria. "Impact of Carcinogenic Chromium on the Cellular Response to Proteotoxic Stress". International Journal of Molecular Sciences (2019): http://dx.doi.org/10.3390/ijms20194901.
    10.3390/ijms20194901
  3. Alves, Celso; Silva, Joana; Pinteus, Susete; Gaspar, Helena; Alpoim, Maria C.; Botana, Luis M.; Pedrosa, Rui. "From Marine Origin to Therapeutics: The Antitumor Potential of Marine Algae-Derived Compounds". Frontiers in Pharmacology 9 (2018): http://dx.doi.org/10.3389/fphar.2018.00777.
    10.3389/fphar.2018.00777
  4. Alpoim, Maria. "Stroma-derived IL-6, G-CSF and Activin-A mediated dedifferentiation of lung carcinoma cells into cancer stem cells.". Scientific Reports 8 (2018): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070555/.
    Open access • Published
  5. Val, M.M.; Mendes, L.A.; Alarcão, A.; Carvalho, L.; Carreira, I.; Rodrigues, C.F.D.; Alpoim, M.C.. "Senescent bronchial fibroblasts induced to senescence by Cr(VI) promote epithelial-mesenchymal transition when co-cultured with bronchial epithelial cells in the presence of Cr(VI)". Mutagenesis 30 2 (2015): 277-286. http://www.scopus.com/inward/record.url?eid=2-s2.0-84935078540&partnerID=MN8TOARS.
    10.1093/mutage/geu070
  6. Alpoim, Maria. "Impact of hexavalent chromium on mammalian cell bioenergetics: phenotypic changes, molecular basis and potential relevance to chromate-induced lung cancer". BioMetals, 409 (2014):
    10.1007/s10534-014-9726-7
  7. Alpoim, Maria. "Molecular and cellular mechanisms of hexavalent chromium-induced lung cancer: an updated perspective". Curr Drug Metab.13(3):284 (2012): http://www.eurekaselect.com/76506/article.
    10.2174/138920012799320464
  8. Gonçalves, M.J.; Santos, A.C.C.; Rodrigues, C.F.D.; Coelho, P.; Costa, A.N.; Guiomar, A.J.; Santos, M.S.; Alpoim, M.C.; Urbano, A.M.. "Changes in glucose uptake rate and in the energy status of PC-12 cells acutely exposed to hexavalent chromium, an established human carcinogen". Toxicological and Environmental Chemistry 93 6 (2011): 1202-1211. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960665821&partnerID=MN8TOARS.
    10.1080/02772248.2011.581340
  9. Alpoim, Maria. "Induction of morphological changes in BEAS-2B human bronchial epithelial cells following chronic sub-cytotoxic and mildly cytotoxic hexavalent chromium exposures.". Mol Carcinog. ;49(6):582. (2010): http://onlinelibrary.wiley.com/doi/10.1002/mc.20624/abstract.
    doi: 10.1002/mc.20624.
  10. Costa, A.N.; Moreno, V.; Prieto, M.J.; Urbano, A.M.; Alpoim, M.C.. "Induction of morphological changes in BEAS-2B human bronchial epithelial cells following chronic sub-cytotoxic and mildly cytotoxic hexavalent chromium exposures". Molecular Carcinogenesis 49 6 (2010): 582-591. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953902669&partnerID=MN8TOARS.
    10.1002/mc.20624
  11. Alpoim, Maria. "Human bronchial epithelial cells malignantly transformed by hexavalent chromium exhibit an aneuploid phenotype but no microsatellite instability". Mutat. Res., 670, 42. (2009): http://ac.els-cdn.com/S0027510709002371/1-s2.0-S0027510709002371-main.pdf?_tid=e20a799e-3d05-11e4-9346-00000aacb360&acdnat=1410805800_41517cc3c03f922dcd49d248a0942d41.
    10.1016/j.mrfmmm.2009.07.004
  12. Urbano, A.M.; Rodrigues, C.F.; Alpoim, M.C.. "Hexavalent chromium exposure, genomic instability and lung cancer". Gene Therapy and Molecular Biology 12 2 (2008): 219-238. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350027212&partnerID=MN8TOARS.
  13. Alpoim, Maria. "A role for transforming growth factor-beta apoptotic signaling pathway in liver injury induced by ingestion of water contaminated with high levels of Cr(VI).". Toxicol. Appli. Pharmacol., 244, 163 (2007): http://www.sciencedirect.com/science/article/pii/S0041008X0700302X.
    10.1016/j.taap.2007.07.004
  14. Alpoim, Maria. "Cr(VI) Reduction by Chromate Resistant Ochrobactrum tritici strain 5bvl1". Can.J. Microbiol., 50, 697. (2004): http://download.springer.com/static/pdf/867/art%253A10.1007%252Fs10534-011-9446-1.pdf?auth66=1410976571_fa373e884c7059a58bb40b8baa1702a2&ext=.pdf.
    10.1007/s10534-011-9446-1
  15. Branco, R.; Alpoim, M.C.; Morais, P.V.. "Ochrobactrum tritici strain 5bvl1 - Characterization of a Cr(VI)-resistant and Cr(VI)-reducing strain". Canadian Journal of Microbiology 50 9 (2004): 697-703. http://www.scopus.com/inward/record.url?eid=2-s2.0-11144351633&partnerID=MN8TOARS.
    10.1139/w04-048
  16. Alpoim, Maria. "Chromium(VI) interaction with plant and animal mitochondrial bioenergetics: A comparative study.". J. Bioch. Mol. Toxicol., 16, 53. (2002): https://estudogeral.sib.uc.pt/bitstream/10316/8343/1/obra.pdf.
    10.1002/jbt.10025
  17. Francisco, R.; Alpoim, M.C.; Morais, P.V.. "Diversity of chromium-resistant and -reducing bacteria in a chromium-contaminated activated sludge". Journal of Applied Microbiology 92 5 (2002): 837-843. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036227993&partnerID=MN8TOARS.
    10.1046/j.1365-2672.2002.01591.x
  18. Alpoim, Maria. "Effects of NADH and H2O2 on Chromate-induced Human Erythrocytes Haemoglobin Oxidation and Peroxidation.". Ecotoxicol. Environ. Safety, 47, 39 (2000): http://www.sciencedirect.com/science/article/pii/S0147651399919395.
    10.1006/eesa.1999.1939
  19. Alpoim, Maria. "Chromate-induced human erythrocytes haemoglobin oxidation and peroxidation: influence of vitamin E, vitamin C, salicylate, deferoxamine, and N-ethylmaleimide.". Toxicol. Lett., 114, 237 (2000): http://www.sciencedirect.com/science/article/pii/S0378427400001673.
    10.1016/S0378-4274(00)00167-3
  20. Alpoim, Maria. "Human Erythrocytes Are Protected Against Chromate Induced Peroxidation". Ecotoxicol. Environ. Safety,, 43, 38-46. (1999): http://ac.els-cdn.com/S0147651398917559/1-s2.0-S0147651398917559-main.pdf?_tid=db447bfa-3cfb-11e4-9bb0-00000aacb35d&acdnat=1410801494_51f81f7843174f22992dc5405c16426d.
    10.1006/eesa.1998.1755
  21. Alpoim, M.C.; Geraldes, C.F.; Oliveira, C.R.; Lima, M.C.. "Molecular mechanisms of chromium toxicity oxidation of hemoglobin". Biochemical Society Transactions 23 2 (1995): http://www.scopus.com/inward/record.url?eid=2-s2.0-0029010431&partnerID=MN8TOARS.
  22. Alpoim, Maria. "Preparation, Physico-Chemical Characterization and Relaxometry Studies of Various Gadolinium(III)-DTPA-Bis(Amide) Derivatives As Potential Magnetic Resonance Contrast Agents.". Magnetic Resonance Imaging, 13, 401. (1995): http://www.sciencedirect.com/science/article/pii/0730725X9400117L.
    10.1016/0730-725X(94)00117-L
  23. Alpoim, Maria. "Determination of the Number of Inner-Sphere Water Molecules in Lanthanide (III) Polyaminocarboxylate Complexes.". J. Chem. Soc. Dalton Trans., 463-469 (1992): http://pubs.rsc.org/en/content/articlehtml/1992/dt/dt9920000463.
    10.1039/DT9920000463
  24. Geraldes, C.F.G.C.; Sherry, A.D.; Marques, M.P.M.; Alpoim, M.C.; Cortes, S.. "Protonation scheme for some triaza macrocycles studied by potentiometry and NMR spectroscopy". Journal of the Chemical Society, Perkin Transactions 2 1 (1991): 137-146. http://www.scopus.com/inward/record.url?eid=2-s2.0-37049076256&partnerID=MN8TOARS.
  25. Alpoim, Maria. "Structure And Dynamics of Lanthanide(III) Complexes of The Bis(propylamide) of Diethylenetriaminepentaacetic Acid in Aqueous Solution.". J. Chem. Soc. Chem. Comm., 656-658. (1991): http://pubs.rsc.org/En/content/articlelanding/1991/c3/c39910000656#!divAbstract.
    10.1039/C39910000656
  26. Alpoim, Maria. "The Protonation Scheme of Some Triaza Macrocycles Studied by Potentiometry and NMR Spectroscopy". J.Chem.Soc.Perkin Trans., 2,137-146 . (1991): http://pubs.rsc.org/en/content/articlelanding/p2/1991/p29910000137#!divAbstract.
    10.1039/P29910000137
  27. Geraldes, C.F.G.C.; Alpoim, M.C.; Marques, M.P.M.; Sherry, A.D.; Singh, M.. "Nuclear Magnetic Resonance and Potentiometrie Studies of the Protonation Scheme of a Triaza Triacetic Macrocycle and Its Complexes with Lanthanum and Lutetium". Inorganic Chemistry 24 23 (1985): 3876-3881. http://www.scopus.com/inward/record.url?eid=2-s2.0-0000237598&partnerID=MN8TOARS.
    10.1021/ic00217a034
Newspaper article
  1. Alpoim, Maria. "Intermediary metabolism: An intricate network at the crossroads of cell fate and function", Bioch Biophys Acta (BBA) - Molecular Basis of Disease, 2020, https://reader.elsevier.com/reader/sd/pii/S0925443920302350?token=90946D0FB0108BFAE94ED2807717F6D7C4E3C6B6ABB9D3BC901B4A1ECD6415583343AF4717425E9D38B732B65DAD0D67.
  2. Alpoim, Maria. "Sphaerococcus coronopifolius bromoterpenes as potential cancer stem cell-targeting agents", Biomed Pharmacotherapy, 2020, https://www.sciencedirect.com/science/article/pii/S0753332220304674.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2014/10 Stromal-orchestrated Paracrine Loops drive Cancer Stem Cells formation in Lung Cancer. 20th International Charles Heidelberger Symposium on Cancer Research, Arica, Chile, October (2014) 20th International Charles Heidelberger Symposium on Cancer Research
Universidade de Arica (Arica, Chile)
2014/04 Stromal cells-derived paracrine factores promote dedifferentiation of human lung carcinoma cells into cancer stem cells. American Association for Cancer Research Annual Meeting. S. Diego, April (2014) American Association for Cancer Research Annual Meeting.
AACR

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2017/07 - Current "Caracterização Genómica de Doentes com Gamapatias Monoclonais"
Co-supervisor
Universidade de Coimbra Faculdade de Medicina, Portugal
2015/01 - 2019/11/08 Sphaerococcus coronopifolius bromoterpenes: Antitumor activity and intracellular signal pathways characterization on in vitro human cellular cancer models
Co-supervisor
Universidade de Aveiro, Portugal
2018/06 - 2019/09/11 The Macrophage-iNKT cells axis: macrophage survival and activation are modulated upon invariant NKT cell interaction
Co-supervisor
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2016/07 - 2017/09/25 “Breaking the ctDNA sensitivity barrier“Laboratório "Genetic Dynamics of Cancer Cells"
Co-supervisor
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2016/07 - 2017/09 "Cytotoxic Effects of Parthenolide on Lymphoid Malignancies - an In Vitro Study"
Co-supervisor
 Biologia Celular e Molecular (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2016/03 - 2017/03 "Stromal cells-derived IL-6, G-CSF and Activin-A induce dedifferentiation of lung carcinoma cells into cancer stem cells"
Supervisor
 Medicina (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2016/05 - 2016/09 "Tracking of intracelular cytokines’ traduced signals"
Co-supervisor
 Bioquímica (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2015/06 - 2016/09 " Molecular characterization of new candidate genes for familial thyroid cancer"
Co-supervisor
 Biologia Celular e Molecular (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2015/05 - 2016/09 "The importance of cytokines-mediated communication in CSCs’ formation"
Co-supervisor
 Biologia Celular e Molecular (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2015 - 2016/09 "Copy Number Variation Analysis in Retinal Angiomatous Proliferation"
Co-supervisor
 Biologia Celular e Molecular (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2011/01 - 2015/11 Estudo Experimental da Resposta do Periodonto Induzida pelo Movimento Dentário Ortodôntico
Co-supervisor
Universidade de Coimbra Faculdade de Medicina, Portugal
2013/09 - 2014/09 "Towards GMP production of gama deltaTCR engineered T cells"
Co-supervisor
 Biologia Celular e Molecular (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2013/07 - 2014/09 "Characterization of Mps1 mutations identified in cancer samples"
Co-supervisor
 Biologia Celular e Molecular (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2013/07 - 2014/09 "New steroidal aromatase inhibitors: biological effects in hormone-dependent breast cancer cell models"
Co-supervisor
 Biologia Celular e Molecular (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2013/07 - 2014/09 "Adoptive cell transfer for immunotherapy in solid tumors: activation and expansions of natural killer cells for eradication of malignant cells"
Supervisor
 Bioquímica (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2013/06 - 2014/09 "Low Doses of Ionizing Radiation Induce Angiogenesis After Radiotherapy"
Co-supervisor
 Biologia Celular e Molecular (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2010/01 - 2014/03/20 Hexavalent Chromium and Lung Cancer: A View to a Kill!
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2012/09 - 2013/09 "Análise do Padrão de Metilação do Carcinoma Pavimento-celular da Cavidade Oral"
Co-supervisor
 Bioquímica (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2012/07 - 2013/09 "Bacterial Protein Azurin as a New Candidate Drug to Treat P-cadherin Overexpressing Breast Cancer"
Supervisor
 Biologia Celular e Molecular (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2012/06 - 2013/09 “Role of metformin as co-adjuvant in anticancer therapy targeting osteosarcoma cancer stem cells“
Co-supervisor
 Bioquímica (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2012/05 - 2013/09 “Ação do radical hidroxilo na resposta celular do cancro da próstata"
Co-supervisor
 Bioquímica (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2012/05 - 2013/09 "Targeting Signaling Pathways as a New Therapeutic Approach in Hepatocellular Carcinoma: an In Vitro Study"
Co-supervisor
 Bioquímica (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2012/05 - 2013/09 "Terapia Fotodinâmica: uma Abordagem no Retinoblastoma"
Co-supervisor
 Bioquímica (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2011/06 - 2012/09 “Cr(VI) carcinogenesis: Understanding the lethal drivers of epithelial-stromal co-evolution”
Supervisor
 Bioquímica (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2011/06 - 2012 “Drug Resistance and Cancer Stem Cells”
Supervisor
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2010/06 - 2011/09 “Estudo da etiologia do autismo utiliozando a técnica de MLPA”
Co-supervisor
Universidade de Coimbra Departamento de Bioquímica, Portugal
2009/06 - 2011/09 “Cr(VI)-induced malignant transformation of a bronchial epithelial cell line association with altered mitochondria and bioenergetic phenotypes
Supervisor
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2009/06 - 2011/09 “The role of senescent fibroblasts on epithelial cells malignant transformation”
Supervisor
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2007/05 - 2009/09 “Metabolic profiling of prostate cancer biopsies by 1HR-MAS“,
Co-supervisor
Universidade de Coimbra Departamento de Bioquímica, Portugal
2007/04 - 2009/09 “Avaliação morfológica do fígado na administração experimental de dimetilhidrazina“.
Co-supervisor
Universidade de Coimbra Departamento de Bioquímica, Portugal
2005/04 - 2007/11 “Estudo dos efeitos tóxicos do crómio hexavalente em rim e fígado de rato Wistar“.
Supervisor
Universidade de Coimbra Faculdade de Medicina, Portugal
2003/09 - 2005 "Parâmetros Envolvidos na Optimização das Condições Utilização de uma Estirpe de Ochrobactrum tritici em Biorremediação"
Co-supervisor
Universidade de Coimbra Departamento de Engenharia Quimica, Portugal
2002/05 - 2004/01 “Estudo Biomorfológico das Glândulas Salivares na Administração Experimental de Ácido Tânico”,
Co-supervisor
Universidade de Coimbra Faculdade de Medicina, Portugal
2001/06 - 2003/05 “Diversidade Microbiológica de um Ambiente Contaminado com Crómio
Co-supervisor
Universidade de Coimbra Departamento de Bioquímica, Portugal
2001/06 - 2003/03 “Caracterização, Estudo da Resistência e Redução de Crómio(VI) de uma Estirpe de Ochrobactrum tritici“
Co-supervisor
Universidade de Coimbra Departamento de Bioquímica, Portugal
2001/10 - 2003 “Determinaçãp dos Efeitos de Exposições de Cr(VI) subcitotóxicas no metabolismo energético de células PC-12”
Co-supervisor
 Bioquímica (Degree)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2001/09 - 2003 “ Efeitos em diferentes parâmetros celulares da exposição de culturas de células PC-12 a crómio hexavalente"
Supervisor
 Bioquímica (Degree)
Universidade de Coimbra Departamento de Bioquímica, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2006/05/21 - 2006/05/24 The congress was organized in collaboration with U.S. Geological Survey; Armed Forces Institute of Pathology (Washington); Nickel Producers Environment Research Association; Faustus Cancer Research Institute, Leipzig-Vienna (Germany-Austria); Institue Internationale de Recherché sur les Ions Métalliques; The International Association for Medical Geology. The event aimed at the presentation of epidemiologic and research data on the carcinogenic effects of metal ions in polluted environments due to industrial/occupational release of metal particulates (2006/05/21 - 2006/05/24)
Congress (President of the Organising Committee)
 Universidade de Coimbra Departamento de Bioquímica, Portugal
1998/05/08 - 1998/08/10 This event aimed at the presentation of epidemiologic and research data on the carcinogenic effects of metal ions in polluted environments due to industrial /occupational release of metal particulates (1998/05/08 - 1998/05/10)
Congress (Member of the Scientific Committee)

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2019/09/24 Targeting senescent endothelial cells
(Thesis) Main arguer
 Ana Lúcia da Silva Cunha (Master)
Universidade de Coimbra Departamento de Física, Portugal
2019/09/17 Therapeutic strategies combined to hepatocellular carcinoma mediated by nanosystems
President of the jury
 Flávia Soraia Cunha Rodrigues (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2019/09/17 Evaluation of ageing-related molecular and bioenergetic alterations in bovine oocytes
(Thesis) Main arguer
 Maria Moreira Soares (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2019/07/22 Cytogenomic Evaluation - Importance of CNVs in Head and Neck Cancer
President of the jury
 Ana Lousã Rodrigues Mendes Santos (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2018/09/25 High-throughput identification of polymeric compounds that affect human vascular cell senescence
(Thesis) Arguer
 Helena Isabel Reis Aires (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2018/09/19 Plasma Atmosférico Frio no tratamento do Retinoblastoma
President of the jury
 Beatriz Pinheiro Lopes (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2018/09/10 Comparação de parâmetros mitocondriais entre oócitos jovens e envelhecidos
President of the jury
 Raquel Direito Fernandes (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2017/09/18 Deteção de novas mutações acionáveis na terapia personalizada em Cancro do Pulmão
President of the jury
 Inês Filipa Paixão Mansinhos (Master)
2017/09 The influence of dietary fiber intake on the development of colorectal carcinoma
(Thesis) Main arguer
 Catarina Isabel Bráz Guilherme (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2017/09 Detection of genetic biomarkers of lung cancer using enhaled breathe condensate
President of the jury
 Beatriz de Almeida Gonçalves Carrilho Mestre (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2017/09 Nucleolin as a functional driver of breast cancer cells
(Thesis) Main arguer
 Catarina da Silva Pechincha (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2017/07 Avaliação da capacidade de transporte e entrega de material genético promovido por nanossistemas de base polimérica
President of the jury
 Daniela Filipa Domingues Santo (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2017/05/12 “Membrana Amniótica: uma opção terapêutica para o cancro”
(Thesis) Main arguer
 Ana Catarina Manjolinha Mamede (PhD)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2016/09 Terapia fotodinâmica em combinação com ácido acetilsalicílico
(Thesis) Main arguer
 Nuno Alexandre Catalão Pina Almeida (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2016/09 Comparasion of extracelular vesicles isolation protocols from the plasma of patients with multiple myeloma: size characterization, expression of EV markers and microRNAs
(Thesis) Main arguer
 Vanessa Patrícia Dias Pinto (Master)
Universidade de Coimbra Departamento de Ciências da Terra, Portugal
2016/09 Do senescente cells in vivo induce a bystander effect in muscle?
President of the jury
 Paulo Francisco Lopes da Silva (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2016/09 Avaliação dos mecanismos moleculares de resistência a hipometilantes em leucemis mieloide aguda
(Thesis) Main arguer
 Patrícia Isabel Martins Corredeira (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2016/07 Modulation of colorectal cancer stem cell pool and its crosstalk with tumor microenvironmentby KRas, BRaf, and PIK3CA mutations
(Thesis) Main arguer
 André Emanuel Serra Roma (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2016/02 Mechanisms of hexavalent chromium carcinogenesis: Effects of the stress response and on the genomic stability of the BEAS-2B cell line
(Thesis) Main arguer
 Patrícia Alexandra Lona Abreu (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2016/01/27 “Role of mitochondria and DNA damage responses in cancer stem cells resistance to chemotherapy”
President of the jury
 Katia de Almeida Henriques (PhD)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015/09 Efficient and synergistic gene delivery mediated by combined polymeric-based nanosystem
(Thesis) Main arguer
 Ana Catarina Ribeiro de Sousa (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2015/09 Age-dependent sensitivity to anti-mitotics: The role of FoxM1 and its therapeutic potential
President of the jury
 Sara Marisa Duarte Vaz (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2015/09 Evaluation of the diagnostic and prognostic value of IDH1 and Progranulin in patients with gliomas
President of the jury
 Marta Alexandra Lopes Ribeiro (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2015/09 Efeitos do crómio hexavalente no metabolismo energético de uma linha celular do epitélio brônquico humano
(Thesis) Main arguer
 Daniela Cravo Ferreira (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2015/07/30 “Unravelling cancer metabolism through flux analysis”
President of the jury
 Ludgero Canário Tavares (PhD)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015 The role of cancer stem cells in breast cancer metastasis
(Thesis) Main arguer
 Madalena da Silva Soares Gomes (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2015 Efeitos do crómio hexavalente no metabolismo energético de uma linha celular do epitélio brônquico humano
(Thesis) Main arguer
 Daniela Cravo Ferreira (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2015 Common MTFHFR, MTR and MTRR polymorphisms in sporadic colo-rectal adenocarcinoma
(Thesis) Main arguer
 José Pedro Coelho Mendes (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2014/12/30 “MicroRNA modulation in combination with chemotherapeutic drugs as a novel therapeutic strategy for pancreatic cancer”
Thesis Member
 Marta Daniela Passadouro Caetano (PhD)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014/09 MiRNAs expression profiling and modulation in Glioblastoma Stem Cells
(Thesis) Main arguer
 Ruben Miguel Gonçalves Branco (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2014/09 Avaliação do perfil de metilação em síndrome mielodisplásica – Estudo comparativo entre sangue periférico e medula óssea
(Thesis) Main arguer
 Joana Margarida Verdasca Jorge (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2014/09 Marcadores moleculares nas células estaminais do cancro da mama triplo negativo versus hormonodependentes
(Thesis) Main arguer
 Tânia Alves da Costa (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2014/07 Towards determining the importance of bone marrow-derived factors in supporting human B acute lymphoblastic leukaemia growth in vivo
(Thesis) Main arguer
 Ana Catarina Farinha Bolhaqueiro (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2014/07 Novel regulator genes controlling mesenchymal stromal cell function and adipose tissue remodelling
President of the jury
 Isabel Sofia de Deus e Sousa (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2014/05/30 “On the reprogramming of the Krebs cycle in hypoxic and VHL-deficient cancer cells”
(Thesis) Arguer
 Paulo Alexandre da Costa Gameiro Guerreiro (PhD)
Universidade de Coimbra, Portugal
2014/03/20 “Hexavalent Chromium and Lung Cancer: A View to a Kill!”
Supervisor
 Carlos Fernando Dias Rodrigues (PhD)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013/09 Creating Organotypic Cultures to Study Colorectal Cancer Using Decellularized Human Matrices
(Thesis) Main arguer
 Marta Larangeiro Pinto (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2013/09 Effects of methamphetamine combined with doxorubicin or methotrexate on malignant glioma and brain endothelial cells
(Thesis) Main arguer
 Tânia Capeloa (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2013/09 Hidróximetil-pirrolo-tiazóis no cancro da mama e a importância da inibição das PARP
(Thesis) Main arguer
 Kathleen Talia Juliano dos Santos (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2013/09 Síntese e caracterização de porfirinas como potenciais agentes fotossensibilizadores em terapia fotodinâmica
(Thesis) Main arguer
 Letícia Daniela da Silva Costa (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2013/09 The role of miR-21 in tumor angiogenesis
(Thesis) Main arguer
 Celina Maria dos Reis Parreira (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2013/09 Vitamina C e quimioterapia: uma potencial sinergia contra o carcinoma colo-rectal
(Thesis) Main arguer
 Cláudia Raquel Ferreira Marques (Master)
Universidade de Coimbra, Portugal
2013/09 Nova abordagem no tratamento de tumores primários do fígado: o papel da quercertina
(Thesis) Main arguer
 Marina Raquel Duarte Ribeiro (Master)
Universidade de Coimbra, Portugal
2013/09 Avaliação da inibição de metaloproteinases da matriz como alvo terapêutico em neoplasias hematológicas
President of the jury
 Ana Claudia da Costa Pires (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2012/12/12 “Mecanismos redox de fármacos e deteção electroquímica in situ de danos causados no DNA”
Thesis Member
 Ana Dora Rodrigues Pontinha (PhD)
Universidade de Coimbra Departamento de Química, Portugal
2012/09 “Toxicidad del Cromo(VI) : Estudio de las interacciones del cromo com componentes cellulares”.
(Thesis) Main arguer
 André Nuno Tavares da Costa (PhD)
Universitat Autònoma de Barcelona Departament de Química, Spain
2012/09 Identificação das vias de sinalização anti-apoptóticas em células estaminais cancerígenas de osteosarcoma
(Thesis) Main arguer
 Claúdia Borges Gonçalves (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2012/09 Químio e radioterapia no carcinoma hepatocelular. Influência da p53
(Thesis) Main arguer
 Ana Rita Basla (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2012/09 Characterization of cancer stem-like properties in canine mammary cancer
(Thesis) Main arguer
 Daniela Sofia Machado Pereira (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2012/09 Avaliação de alterações genéticas e epigenéticas envolvidas na susceptibilidade a cancro na Sindrome de Down
President of the jury
 Patrícia Isabel Silva Guarino (Master)
Universidade de Coimbra, Portugal
2012/09 Importância do TRAIL e da Survivina como alvos terapêuticos na leucemia linfoblástica aguda
(Thesis) Main arguer
 Cátia Sofia da Costa Domingues (Master)
Universidade de Coimbra, Portugal
2012/09 Complexos polinucleares de poliaminas com platina(II). E paládio(II) como promissores agentes anti-cancerígenos face ao cancro da prostata
(Thesis) Main arguer
 Carina Saraiva de Matoso (Master)
Universidade de Coimbra, Portugal
2012/09 Cr(VI) carcinogenesis: Understanding the lethal drivers of epithelial-stromal co-evolution
Supervisor
 Mariana Monteiro Val (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2012/09 Drug Resistance and Cancer Stem Cells
Supervisor
 João Pedro Couto Fonseca (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2012/06/27 “Pathways for the synthesis and hydrolysis of some compatible solutes in the bacterium Rubrobacter xylanophilus and in the plant Seraginella moellendorrffii”
Thesis Member
 Ana Luísa Nobre (PhD)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2011/12/16 “Mecanismos redox de compostos aromáticos, aminoácidos e proteínas, em eléctrodos de carbono”.
Thesis Member
 Teódor Adrian Enache (PhD)
Universidade de Coimbra- FCTUC Departamento de Química, Portugal
2011/11 “Profiling the control of hepatic glucose and lipid metabolism for evaluating novel strategies of insulin delivery”.
(Thesis) Arguer
 Ana Francisca Leal da Silva Soares (PhD)
2011/09 Polyamine conjugates as potential therapeutic antiproliferative agents
(Thesis) Main arguer
 Rui Traquete (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2011/09 Cr(VI)-induced malignant transformation of a bronchial epithelial cell line association with altered mitochondria and bioenergetic phenotypes
Supervisor
 Ana Daniela Pinto Ferreira Sampaio (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2011/09 The role of senescent fibroblasts on epithelial cells malignant transformation
Supervisor
 Luís André da Gama Lima Mendes (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2011/09 Establishement of primary cell cultures from lung tissue biopsies and study of the cellular metabolic responses to cisplatin and radiation exposure
(Thesis) Main arguer
 Ana Filipa Ferreira Ladeirinha (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2011/09 Potencial terapêutico de siRNA e anti-FLT3 em neoplasias hematológicas
(Thesis) Main arguer
 Ana Raquel Martins Figueiredo Fonseca (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2011/09 Effect of short-term Cr(VI) exposure on energy metabolism in human lung epithelial cells
(Thesis) Main arguer
 Joana Felício Cerveira (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2011/07 Impact of therapeutic gene silencing on cancer cell lines of different histologic origins
(Thesis) Main arguer
 Carla Maria Pereira Gomes (Master)
Universidade de Coimbra, Portugal
2011/07 Identifying mechanisms of resistance to chemotherapy in osteosarcoma tumor stem cells
(Thesis) Main arguer
 Vitor Emanuel Bucete Oliveira (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2011/07 The role of GRIM-19 and interacting proteins in human tumors
(Thesis) Main arguer
 Marcelo José Marques Correia (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2011/07 Estudo da etiologia do autismo utilizando a técnica de MLPA
President of the jury
 Tânia Sofia Trindade Afonso (Master)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2011/03 Avaliação da capacidade citotóxica de macroalgas da costa de Peniche (Portugal) em células tumorais humanas
(Thesis) Main arguer
 Celso Miguel da Maia Alves (Master)
Instituto Politécnico de Leiria Escola Superior de Turismo e Tecnologia do Mar de Peniche, Portugal
2011/02/21 “Métodos electroquímicos, síntese orgânia e estudo dos mecanismos redox relativos à actividade antioxidante e pró-oxidante de sistemas fenólicos”
Thesis Member
 Patrícia Janeiro Sueiro (PhD)
2011/02/21 “Biossensores electroquímicos com DNA: Desenvolvimento e aplicações para detecção in situ de danos oxidativos causados ao DNA”
Thesis Member
 Severino Carlos Bezerra de Oliveira (PhD)
Universidade de Coimbra- FCTUC Departamento de Química, Portugal
2010/09 Accção intracelular da terapia fotodinâmica
(Thesis) Main arguer
 Mafalda Sofia Laranjo Cândido (Master)
Universidade de Coimbra, Portugal
2010/09 Characterization of cancer stem cells in gastric cancer resistance to chemotherapy
(Thesis) Main arguer
 Joana Isabel Martins Cosme Vieira de Castro (Master)
Universidade de Coimbra, Portugal
2010/07 Cellular effects and signalling pathways induced by MLK3 mutations
(Thesis) Main arguer
 Ana Teresa Ferreira Correia Pinto (Master)
Universidade de Coimbra, Portugal
2009/11/18 “Dissimilar effects of Cr(VI) species in Ochrobactrum tritici 5bvl1 cultures and modulation by iron”.
Thesis Member
 Romeu Miranda Francisco (PhD)
Universidade de Coimbra Departamento de Bioquímica, Portugal
2009/09 Characterization of an animal model of Alzheimer’s disease
President of the jury
 Nuno Miguel de Jesus Machado (Master)
Universidade de Coimbra, Portugal
2009/07/28 “Complexos de paládio com ligandos biológicos: estudo electroquímico da interacção com o ADN”
Thesis Member
 Oana Cojuhovschi (PhD)
Universidade de Coimbra Departamento de Química, Portugal
2009/07/24 “Heavy metal resistance mechanisms in species Ochrobactrum tritici: the case of arsenic and chromium”.
Thesis Member
 Rita Susana Rosa Branco (PhD)
Universidade de Coimbra Departamento de Bioquímica, Portugal
2009/07/24 “Osmotic and thermal adaptation in ancient and thermophilic bacteria”
Thesis Member
 Chantal Ana Vicência (PhD)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2009/07 Estudo da etiologia do autismo utilizando as técnicas de FISH e MLPA
President of the jury
 Sónia Margarida Tavares Matos Almeida (Master)
Universidade de Coimbra Departamento de Bioquímica, Portugal
2009/07 Descriçãpo de duas espécies novas do género Undibacterium isoladas de um ambiente contaminado com urânio
President of the jury
 André Manuel Almeida Lopes (Master)
Universidade de Coimbra Departamento de Bioquímica, Portugal
2008/09 Novas abordagens terapêuticas no cancro oral. Avaliação de um inibidor de cinases de tirosina e de um inibidor de proteosoma
(Thesis) Main arguer
 Diana Raquel Bento Moreira (Master)
Universidade de Coimbra Departamento de Bioquímica, Portugal
2003/04 Metais Pesados em Produtos da Pesca e da Aquicultura
(Thesis) Main arguer
 Miguel Eduardo da Costa Reis Santos (Master)
Universidade de Lisboa Centro de Ciência e Tecnologia do Ambiente e do Mar, Portugal
2003/01 Mecanismos de Toxicidade Induzidos pela L-Dopa e Dopamina: Implicações na Doença de Parkinson
President of the jury
 Rui Filipe Pinto Pedrosa (Master)
Universidade de Coimbra Departamento de Bioquímica, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
1997/01 - 2008/01 Membro do Júri para Avaliação de Capacidade para Acesso ao Ensino Superior, para a Licenciatura em Bioquímica.
Specialist
 Universidade de Coimbra, Portugal Universidade de Coimbra