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Daniela Rosendo da Silva. Concluiu a Licenciatura em Bioquímica em 2018/06/25 pela Universidade de Coimbra Faculdade de Ciencias e Tecnologia. Concluiu o Mestrado integrado em Biologia Celular e Molecular pelo(a) Universidade de Coimbra Faculdade de Ciencias e Tecnologia em 2020/11/16. É estudante de Doutoramento em Ciências da Saúda na Faculdade de Medicina da Universidade de Coimbra. Atua na(s) área(s) de Ciências Naturais com ênfase em Ciências Biológicas com ênfase em Biologia Celular e Molecular.
Identification

Personal identification

Full name
Daniela Rosendo da Silva

Citation names

  • Rosendo-Silva, Daniela

Author identifiers

Ciência ID
7917-FA1E-3449
ORCID iD
0000-0002-4276-5920

Knowledge fields

  • Natural sciences - Biological Sciences - Cell Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Elementary (A2) Intermediate (B1) Elementary (A2) Intermediate (B1) Beginner (A1)
Education
Degree Classification
2021/09 - 2024
Ongoing
 Doutoramento em Ciências da Saúde (Doutoramento)
Major in Biociências
Universidade de Coimbra Faculdade de Medicina, Portugal
2018/11 - 2020/11/16
Concluded
 Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"THE GUT-ADIPOSE TISSUE CROSSTALK: UNRAVELLING THE MECHANISMS OF GHRELIN-MEDIATED REGULATION OF ADIPOSE TISSUE ANGIOGENESIS" (THESIS/DISSERTATION)
 18.4
2015 - 2018
Concluded
 Bioquímica (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
 16.05
Affiliation

Science

Category
Host institution 		Employer
2021/03/15 - 2021/09/15 Contracted Researcher (Research) Universidade de Coimbra Faculdade de Medicina, Portugal
Center for Innovation in Biomedicine and Biotechnology (CIBB), Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2025/09/08 - Current Invited Assistant (Polytechnic Teacher) Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal

Others

Category
Host institution 		Employer
2019/08/13 - 2021/03/14 Estagiário de Investigação Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal
2019/03/01 - 2019/03/30 Estagiário de Investigação Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/02/01 - 2019/02/28 Estagiário de Investigação Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/02/01 - 2018/06/25 Estagiário de Investigação Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal
Projects

Contract

Designation Funders
2023/03/01 - 2028/08/31 PAS GRAS - De-risking metabolic, environmental and behavioral determinants of obesity in children, adolescents and young adults
HORIZON-HLTH-2022-STAYHLTH- 101080329
Universidade de Coimbra, Portugal
 European Commission
Ongoing
2023/03/01 - 2024/08/31 New THerapeutIc strategies for obesity based oN peripheral dopamiNERgic signalling
2022.05822.PTDC
10.54499/2022.05822.PTDC
Universidade de Coimbra, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Conference abstract
  1. Lopes, Eduardo; Rosendo-Silva, Daniela; Matafome, Paulo. Corresponding author: Lopes, Eduardo. "Peripherical crosstalk between Dopamine, Neuropeptide Y and Melanocortin systems". Paper presented in 57th Annual Scientific Meeting of the European Society for Clinical Investigation, Prague, 2023.
    Published
  2. Rosendo-Silva, Daniela; Eickhoff H; Gomes, P.; Pires, A. S.; Abrantes, Ana Margarida; Botelho, Maria Filomena; Seiça, R; Matafome, Paulo. "Alterações do sistema grelina/NPY do tecido adiposo como alvo terapêutico na diabetes tipo 2". Paper presented in 17º Congresso Português de Diabetes, 2021.
Conference poster
  1. Rosendo-Silva, Daniela. "A GASTRECTOMIA EM SLEEVE MODULA OS COMPONENTES DO EIXO GRELINA-NPY NO TECIDO ADIPOSO DE UM MODELO ANIMAL OBESO E DIABÉTICO TIPO 2". Paper presented in 16º Congresso da Sociedade Portuguesa de Diabetologia, 2020.
Journal article
  1. Daniela Rosendo-Silva; Eduardo Lopes; Tamaeh Monteiro-Alfredo; Inês Falcão-Pires; Hans Eickhoff; Sofia Viana; Flávio Reis; et al. "The adipose tissue melanocortin 3 receptor is targeted by ghrelin and leptin and may be a therapeutic target in obesity". Molecular and Cellular Endocrinology (2024): https://doi.org/10.1016/j.mce.2024.112367.
    10.1016/j.mce.2024.112367
  2. Rosendo-Silva, Daniela; Gomes, Pedro Bastos; Rodrigues, Tiago; Viana, Sofia; da Costa, André Nogueira; Scherer, Philipp E.; Reis, Flávio; et al. "Clinical and molecular profiling of human visceral adipose tissue reveals impairment of vascular architecture and remodeling as an early hallmark of dysfunction". Metabolism 153 (2024): 155788. https://doi.org/10.1016/j.metabol.2024.155788.
    Published • 10.1016/j.metabol.2024.155788
  3. Andreia Amaro; Diana Sousa; Mariana Sá-Rocha; Marcos Divino Ferreira-Junior; Daniela Rosendo-Silva; Lucas Paulo Jacinto Saavedra; Cátia Barra; et al. "Postnatal Overfeeding in Rodents Induces a Neurodevelopment Delay and Anxious-like Behaviour Accompanied by Sex- and Brain-Region-Specific Synaptic and Metabolic Changes". Nutrients (2023): https://doi.org/10.3390/nu15163581.
    10.3390/nu15163581
  4. Rosendo-Silva, Daniela; Viana, Sofia; Carvalho, Eugénia; Reis, Flávio; Matafome, Paulo. "Are gut dysbiosis, barrier disruption, and endotoxemia related to adipose tissue dysfunction in metabolic disorders? Overview of the mechanisms involved". Internal and Emergency Medicine 18 5 (2023): 1287-1302. https://doi.org/10.1007/s11739-023-03262-3.
    Published • 10.1007/s11739-023-03262-3
  5. Diana Sousa; Mariana Rocha; Andreia Amaro; Marcos Divino Ferreira-Junior; Keilah Valéria Naves Cavalcante; Tamaeh Monteiro-Alfredo; Cátia Barra; et al. "Exposure to Obesogenic Environments during Perinatal Development Modulates Offspring Energy Balance Pathways in Adipose Tissue and Liver of Rodent Models". Nutrients (2023): https://doi.org/10.3390/nu15051281.
    10.3390/nu15051281
  6. Diana Sousa; Eduardo Lopes; Daniela Rosendo-Silva; Paulo Matafome. "The Bidirectional Relationship of NPY and Mitochondria in Energy Balance Regulation". Biomedicines (2023): https://doi.org/10.3390/biomedicines11020446.
    10.3390/biomedicines11020446
  7. Gabriela Tavares; Daniela Rosendo-Silva; Flávia Simões; Hans Eickhoff; Daniela Marques; Joana F. Sacramento; Adriana M. Capucho; et al. "Circulating Dopamine Is Regulated by Dietary Glucose and Controls Glucagon-like 1 Peptide Action in White Adipose Tissue". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24032464.
    10.3390/ijms24032464
  8. Tavares, G.; Marques, D.; Barra, C.; Rosendo-Silva, D.; Costa, A.; Rodrigues, T.; Gasparini, P.; et al. "Dopamine D2 receptor agonist, bromocriptine, remodels adipose tissue dopaminergic signalling and upregulates catabolic pathways, improving metabolic profile in type 2 diabetes". Molecular Metabolism 51 (2021): 101241. http://dx.doi.org/10.1016/j.molmet.2021.101241.
    10.1016/j.molmet.2021.101241
  9. Monteiro-Alfredo, Tamaeh; Caramelo, Beatriz; Arbelaez, Daniela; Amaro, Andreia; Barra, Cátia; Rosendo-Silva, Daniela; Oliveira, Sara; Seiça, Raquel; Matafome, Paulo. "Distinct Impact of Natural Sugars from Fruit Juices and Added Sugars on Caloric Intake, Body Weight, Glycaemia, Oxidative Stress and Glycation in Diabetic Rats". Nutrients 13 9 (2021): 2956-2956. http://dx.doi.org/10.3390/nu13092956.
    10.3390/nu13092956
  10. Monteiro-Alfredo, Tamaeh; Oliveira, Sara; Amaro, Andreia; Rosendo-Silva, Daniela; Antunes, Katia; Pires, Ana Salomé; Teixo, Ricardo; et al. "Hypoglycaemic and Antioxidant Properties of Acrocomia aculeata (Jacq.) Lodd Ex Mart. Extract Are Associated with Better Vascular Function of Type 2 Diabetic Rats". Nutrients 13 8 (2021): 2856. http://dx.doi.org/10.3390/nu13082856.
    10.3390/nu13082856
  11. Monteiro, Tamaeh; Rosendo-Silva, Daniela; Oliveira, S.; Antunes, K.A.; AS Pires; Teixo, Ricardo Jorge Marques; Abrantes, Ana Margarida; et al. "Acrocomia aculeata (Jacq.) Lodd ex Mart. leaves aqeous extract improves redox-homeostasis and diabetes complications". European Journal of Clinical Investigation 51 S1 (2021): http://dx.doi.org/10.1111/eci.13564.
    10.1111/eci.13564
  12. Rosendo-Silva, Daniela; Matafome, Paulo. "Gut–adipose tissue crosstalk: A bridge to novel therapeutic targets in metabolic syndrome?". Obesity Reviews 22 2 (2021): http://dx.doi.org/10.1111/obr.13130.
    10.1111/obr.13130
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2025/09/16 Adipose tissue bacterial load is increased in hyperglycemic individuals with obesity and correlates with intestinal permeability in T2D 61 st EASD Annual Meeting
European Association for the Study of Diabetes (Viena, Austria)
2024/11/08 A new model of adipose tissue dysfunction in obesity reveals early alterations of the vasculature and remodelling 3º Encontro Internacional da Sociedade Portuguesa de Fisiologia
Sociedade Portuguesa de Fisiologia (Porto, Portugal)
2024/09/12 The neuropeptide Y/melanocortin system in white adipose tissue is regulated by ghrelin and leptin and is impaired in patients with insulin resistance 60th EASD Annual Meeting
European Association for the Study of Diabetes (Madrid, Spain)
2023/10/04 Loss of adipose tissue plasticity as an early hallmark of insulin resistance and metabolic maladaptation in patients with obesity 59th EASD Annual Meeting
European Association for the Study of Diabetes (Hamburgo, Netherlands)
2023/03/17 (Dis)função do tecido adiposo associada à obesidade: identificação de marcadores moleculares para novas abordagens terapêuticas 19º Congresso Português de Diabetes
Sociedade Portuguesa de Diabetologia (VILAMOURA, Portugal)

Association member

Society Organization name Role
2024/10 - Current Sociedade Portuguesa de Fisiologia Membro
2023/04 - Current European Association for the Study of Diabetes Membro
2020/02 - Current Sociedade Portuguesa de Diabetologia Sócio
Distinctions

Award

2025 Outstanding PostGRADUATE Trainee Award from the Portuguese Physiological Society
2021 Prémio de Melhor Póster Científico
European Society for Clinical Investigation, Netherlands