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Adriana Isabel do Vale Marcelo. Concluiu o(a) Doutoramento em Doutoramento em Ciências Biomédicas em 2022/01/26 pelo(a) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Mestrado em Investigação Biomédica em 2016/09 pelo(a) Universidade de Coimbra Faculdade de Medicina e Licenciatura em Ciências Biomédicas em 2014/07 pelo(a) Universidade do Algarve Departamento de Ciências Biomédicas e Medicina. Publicou 9 artigos em revistas especializadas. Orientou 1 trabalho(s) de conclusão de curso de licenciatura/bacharelato e coorientou 1. Recebeu 5 prémio(s) e/ou homenagens. Participa e/ou participou como Bolseiro de Doutoramento em 1 projeto(s) e Bolseiro de Investigação em 1 projeto(s). Atua na(s) área(s) de Ciências Médicas e da Saúde com ênfase em Medicina Básica com ênfase em Neurociências e Ciências Médicas e da Saúde com ênfase em Biotecnologia Médica com ênfase em Diagnóstico e Terapias de Base Genética. No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: grânulos de stress; doenças de poliglutaminas; terapia génica; mecanismos moleculares; .
Identification

Personal identification

Full name
Adriana Isabel do Vale Marcelo

Citation names

  • Marcelo, Adriana

Author identifiers

Ciência ID
7613-00C2-1621
ORCID iD
0000-0002-7327-0170

Email addresses

  • adrianamarcelo11@hotmail.com (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Medical and Health Sciences - Medical Biotechnology - Gene-based Diagnostics and Therapeutic Interventions

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2017/09/26 - 2022/01/26
Concluded
Doutoramento em Ciências Biomédicas (Doutoramento)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
"Stress granules in Polyglutamine diseases: new targets for therapeutic intervention?" (THESIS/DISSERTATION)
Aprovado com Muito Bom com Distinção e Louvor
2021/02/05 - 2021/05/14
Concluded
StartUp Research (Pós-Graduação)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Aprovado
2014/09 - 2016/09
Concluded
Investigação Biomédica (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
"Systemic Transplantation of Mesenchymal Stromal Cells: a therapeutic strategy for Machado-Joseph Disease?" (THESIS/DISSERTATION)
18
2011/09 - 2014/07
Concluded
Ciências Biomédicas (Licenciatura)
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
"Caracterização de um novo polímero híbrido" (THESIS/DISSERTATION)
15
Affiliation

Others

Category
Host institution
Employer
2017/10/01 - 2021/11/30 Bolseiro de Doutoramento FCT Fundação para a Ciência e a Tecnologia, Portugal
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
(...)
2017/04/01 - 2017/09/30 Bolseiro de Investigação para Mestre (BIM) Universidade do Algarve, Portugal
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
Projects

Grant

Designation Funders
2017 - Current Stress granules in Polyglutamine diseases: new targets for therapeutic intervention
SFRH/BD/133192/2017
PhD Student Fellow
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2017 - 2017/09/30 Ataxin-2 as a new molecular target in Machado-Joseph disease: from translation regulation to disease alleviation
18876
Research Fellow
Universidade do Algarve, Portugal
AFM-Téléthon
Concluded

Contract

Designation Funders
2020 - Current Development of a new assay do detect SARS-CoV-2 directly from clinical samples
126_596760136
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019 - Current Overexpression of the RNA-binding protein X as a therapeutic strategy to Machado-Joseph disease and other Polyglutamine diseases
#22424
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
AFM-Téléthon
Ongoing
2018 - 2021/10/12 O papel dos grânulos de stress nas doenças de poliglutaminas: da patogénese à terapia molecular
PTDC/MED-NEU/29480/2017
Universidade do Algarve, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018 - 2019/12 Neuroprotective therapeutic approach for Spinocerebellar Ataxia type 2: pharmacological targeting of AMPK.
ZUNIALGA
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
Ataxia UK
Concluded
Outputs

Publications

Conference poster
  1. "From molecular mechanisms to therapy: a new lentiviral mouse model for Spinocerebellar ataxia type 2". Paper presented in XVII Meeting of Portuguese Society for Neuroscience (SPN 2021), 2021.
  2. "Autophagy Impairment in Spinocerebellar Ataxia Type 2: First Evidences and a Potential Therapeutic Strategy". Paper presented in 24th Annual Meeting of the Portuguese Society of Human Genetics, 2021.
  3. "Study of Autophagy in Spinocerebellar Ataxia Type 2 Models: From Dysfunction to a Therapeutic Approach". Paper presented in JCB-JEM Symposium, 2021.
  4. "Striatal neuropathology in spinocerebellar ataxia type 2: a new lentiviral mouse model". Paper presented in FENS 2020 Virtual Forum, 2020.
  5. Marcelo, Adriana; Koppenol, Rebekah; Matos, Carlos A; Nóbrega, Clévio David Rodrigues. "A lentiviral genetic mouse model for Spinocerebellar ataxia type 2". Paper presented in International Meeting of the Portuguese Society of Genetics (IMPSG2020), 2020.
  6. Kumar, Sajal; Zhong, Hua; Sharma, Ruby; Li, Yiyi; Song, Mingzhou. "RNA-binding proteins: new molecular targets for polyglutamine diseases". Paper presented in XVI Meeting of Portuguese Society for Neuroscience (SPN2019), 2019.
    10.1109/bibm.2018.8621502
  7. Nóbrega, Clévio David Rodrigues ; Mendonça, Liliana; Marcelo, Adriana; Lamazière, Antonin; Tomé, Sandra; Despres, Gaetan; Matos, Carlos A; et al. "CYP46A1 - Gene therapy alleviates Machado-Joseph disease". Paper presented in XVI Meeting of Portuguese Society for Neuroscience (SPN2019), 2019.
  8. Koppenol, Rebekah; Marcelo, Adriana; Matos, Carlos A; Carmo-Silva, Sara; Pereira de Almeida, Luis ; Nóbrega, Clévio David Rodrigues. "On the role of stress granules in autophagy.". Paper presented in XVI Meeting of Portuguese Society for Neuroscience (SPN2019), 2019.
  9. Miranda, Catarina Oliveira; Marcelo, Adriana; Silva, Teresa P.; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Duarte, Sónia; et al. "Sustainable phenotypic ameliorations in Machado-Joseph Disease/Spinocerebelar ataxia type-3 can be reached by repeated systemic administrations of mesenchymal stromal cells – and can be monitored through proton Magnetic Resonance Spectroscopy biomarkers.". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), 2019.
  10. Tomé, Sandra; Marcelo, Adriana; Carmo-Silva, Sara; Ferreira, Marco; Pereira de Almeida, Luis ; Nóbrega, Clévio David Rodrigues. "RNA-binding proteins in Polyglutamine diseases: from pathogenesis to molecular therapy". Paper presented in 11th Forum of Neuroscience (FENS), 2018.
Journal article
  1. Adriana Marcelo; Inês T. Afonso; Ricardo Afonso-Reis; David V. C. Brito; Rafael G. Costa; Ana Rosa; João Alves-Cruzeiro; et al. "Autophagy in Spinocerebellar ataxia type 2, a dysregulated pathway, and a target for therapy". Cell Death & Disease (2021): https://doi.org/10.1038/s41419-021-04404-1.
    10.1038/s41419-021-04404-1
  2. Adriana Marcelo; Rebekah Koppenol; Luís Pereira de Almeida; Carlos A. Matos; Clévio Nóbrega. "Stress granules, RNA-binding proteins and polyglutamine diseases: too much aggregation?". Cell Death & Disease (2021): https://doi.org/10.1038/s41419-021-03873-8.
    10.1038/s41419-021-03873-8
  3. Barros I; Marcelo A; Silva TP; Barata J; Rufino-Ramos D; Pereira de Almeida L; Miranda CO. "Mesenchymal Stromal Cells' Therapy for Polyglutamine Disorders: Where Do We Stand and Where Should We Go?". Frontiers in cellular neuroscience (2020): http://europepmc.org/abstract/med/33132851.
    10.3389/fncel.2020.584277
  4. Nóbrega, Clévio; Conceição, André; Costa, Rafael G.; Koppenol, Rebekah; Sequeira, Raquel L.; Nunes, Ricardo; Carmo-Silva, Sara; et al. "The cholesterol 24-hydroxylase activates autophagy and decreases mutant huntingtin build-up in a neuroblastoma culture model of Huntington’s disease". BMC Research Notes 13 1 (2020): http://dx.doi.org/10.1186/s13104-020-05053-x.
    Open access • Published • 10.1186/s13104-020-05053-x
  5. Nóbrega, Clévio; Mendonça, Liliana; Marcelo, Adriana; Lamazière, Antonin; Tomé, Sandra; Despres, Gaetan; Matos, Carlos A.; et al. "Restoring brain cholesterol turnover improves autophagy and has therapeutic potential in mouse models of spinocerebellar ataxia". Acta Neuropathologica 138 5 (2019): 837-858. http://dx.doi.org/10.1007/s00401-019-02019-7.
    Published • 10.1007/s00401-019-02019-7
  6. Nunes, Catarina; Mestre, Isa; Marcelo, Adriana; Koppenol, Rebekah; Matos, Carlos A; Nóbrega, Clévio. "MSGP: the first database of the protein components of the mammalian stress granules". Database 2019 (2019): http://dx.doi.org/10.1093/database/baz031.
    Open access • Published • 10.1093/database/baz031
  7. Marcelo, Adriana; Brito, Filipa; Carmo-Silva, Sara; Matos, Carlos A; Alves-Cruzeiro, João; Vasconcelos-Ferreira, Ana; Koppenol, Rebekah; et al. "Cordycepin activates autophagy through AMPK phosphorylation to reduce abnormalities in Machado–Joseph disease models". Human Molecular Genetics 28 1 (2018): 51-63. http://dx.doi.org/10.1093/hmg/ddy328.
    Published • 10.1093/hmg/ddy328
  8. Oliveira Miranda, Catarina; Marcelo, Adriana; Silva, Teresa Pereira; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Nóbrega, Clévio; et al. "Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease". Molecular Therapy 26 9 (2018): 2131-2151. http://dx.doi.org/10.1016/j.ymthe.2018.07.007.
    Open access • 10.1016/j.ymthe.2018.07.007
  9. Ana V. Oliveira; Adriana Marcelo; Ana M. Rosa da Costa; Gabriela A. Silva. "Evaluation of cystamine-modified hyaluronic acid/chitosan polyplex as retinal gene vector". Materials Science and Engineering: C 58 (2016): 264-272. https://doi.org/10.1016%2Fj.msec.2015.08.047.
    10.1016/j.msec.2015.08.047

Other

Other output
  1. The stress granule protein G3BP1 reduces the levels of different polyglutamine proteins and alleviates spinocerebellar ataxia associated deficits. 2021. Rebekah Koppenol; André Conceição; Adriana Marcelo; Sandra Tomé; José-Miguel Côdesso; Liliana Mendonça; Luis Pereira de Almeida; Carlos Matos; Clévio Nóbrega. https://doi.org/10.21203/rs.3.rs-668663/v1.
    10.21203/rs.3.rs-668663/v1
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/02 Autophagy Dysfunction in Spinocerebellar Ataxia Type 2 Models and a Potential Therapeutic Strategy 51 st Meeting of the Portuguese Society of Pharmacology, 39 th Meeting of the Clinical Pharmacology and 20 th Meeting of the Toxicology
Universidade de Lisboa
2021/02 RBP-X protein mitigates motor deficits in different mice models of Polyglutamine diseases 51 st Meeting of the Portuguese Society of Pharmacology, 39 th Meeting of the Clinical Pharmacology and 20 th Meeting of the Toxicology
2021/02 Mapping the domains of RBP-X towards mitigation of the pathological phenotype in Polyglutamine disease models 51 st Meeting of the Portuguese Society of Pharmacology, 39 th Meeting of the Clinical Pharmacology and 20 th Meeting of the Toxicology
2021/02 The stress granule protein G3BP1 expression reverts pathological defects in two different polyglutamine diseases 52nd Meeting of the Portuguese Society of Pharmacology, 40th Meeting of the Clinical Pharmacology and 21st Meeting of the Toxicology
Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto (Porto, Portugal)
2021/02 Upregulation of autophagy as a therapeutic strategy for SCA2 disease 52nd Meeting of the Portuguese Society of Pharmacology, 40th Meeting of the Clinical Pharmacology and 21st Meeting of the Toxicology
Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto (Porto, Portugal)
2020/02/07 RNA-binding proteins as potential therapeutic targets for Polyglutamine diseases. L Reunião Anual da Sociedade Portuguesa Farmacologia, Coimbra, Portugal
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2020/02/06 Stress granules crosstalk with autophagy in the context of polyglutamine diseases. L Reunião Anual da Sociedade Portuguesa Farmacologia
Sociedade Portuguesa Farmacologia (Coimbra, Portugal)
2020/01/24 Stress granules dynamics in polyglutamine diseases. International Meeting of the Portuguese Society of Genetics (IMPSG2020)
Sociedade Portuguesa de Genética (Faro, Portugal)
2019/12 MSC Success in Promoting Ameliorations in Machado-Joseph Disease - Where do We Stand and Where We Should Go? Center for Innovative Biomedicine and Biotechnology (CIIB) Meeting
(Coimbra, Portugal)
2019/11/14 CYP46A1 - gene therapy improves Machado-Joseph disease in mouse models. 23ª Reunião Anual da Sociedade Portuguesa de Genética Humana
Sociedade Portuguesa de Genética Humana (Coimbra, Portugal)
2019/10 Spectroscopic Biomarkers as a Way of Monitoring MSC Success in Promoting Neuropathological and Phenotypic Ameliorations in Machado-Joseph Disease Models 11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE TC)
(Lisboa, Portugal)
2019/05 Repeated transplantation of mesenchymal stromal cells in Machado-Joseph Disease/Spinocerebelar ataxia type 3 can sustainably alleviate phenotypic symptoms and ameliorations can be monitored through magnetic resonance spectroscopy 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI)
(Coimbra, Portugal)
2019/03/29 Development and characterization of a lentiviral mouse model for spinocerebellar ataxia type 2. 3as Jornadas do Algarve Biomedical Center (ABC)
Algarve Biomedical Center (ABC) (Albufeira, Portugal)
2019/02 CYP46A1 overexpression alleviates Machado Joseph disease XLIX Reunião Anual da Sociedade de Farmacologia
(Porto)
2018/10 CYP46A1 - Gene therapy alleviates spinocerebellar ataxia in mouse models 26 th Congress of the European Society of Gene and Cell Therapy (ESGCT)
(Lausanne)
2018/03 Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph Disease/Spinocerebelar ataxia type 3 AND therapeutic success can be monitored by 1H-MRS SPDMov 2018 Meeting - “Genética nas Doenças do Movimento”
(Curia, Portugal)
2018/02/06 Pharmacological targeting of AMPK signalling pathway as a therapeutic approach to Polyglutamine diseases. XLVIII Reunião Anual da Sociedade Portuguesa Farmacologia
Sociedade Portuguesa Farmacologia (Lisboa, Portugal)
2018/02 Repeated mesenchymal stromal cells treatment sustainably alleviates Machado Joseph disease XLVIII Reunião Anual da Sociedade Portuguesa Farmacologia
(Lisboa, Portugal)
2017/11/17 Role of RNA binding proteins in polyglutamine diseases. 21ª Reunião Anual da Sociedade Portuguesa de Genética Humana
Sociedade Portuguesa de Genética Humana (Caparica, Portugal)
2017/09/08 Targeting AMPK as a therapeutic strategy to spinocerebellar ataxias. 2nd CBMR/ProRegeM Meeting
Centro de Investigação em Biomedicina (CBMR) (Faro, Portugal)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2021/04 - 2021/07 Estudo do papel do componente dos grânulos de stress CARHSP1 nas doenças de Poliglutaminas
Supervisor
Ciências Biomédicas (Degree)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2020/04/01 - 2020/07 Alvos terapêuticos para a ataxia espinocerebelosa do tipo 2: o que foi feito?
Co-supervisor
Ciências Biomédicas (Degree)
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal

Association member

Society Organization name Role
2020/01 - Current International Society for Neurochemistry (ISN)
2020/01 - Current Sociedade Portuguesa de Genética (SPG)
2019/05 - Current Sociedade Portuguesa de Neurociências (SPN)
2018/01 - Current European Society for Neurochemistry (ESN)
Distinctions

Award

2021 SPN2021 Scholarship
Sociedade Portuguesa de Neurociências, Portugal
2021 StartUp Research Post-Graduation Program Attendance Scholarship
Câmara Municipal de Oeiras, Portugal
2020 Prémio Professor Doutor Luís Archer para Melhor Poster
Sociedade Portuguesa de Genética, Portugal
2020 FENS Grant and Voucher Programme grant
Federation of European Neuroscience Societies, Belgium
2017 PhD fellowship (SFRH/BD/133192/2017)
Fundação para a Ciência e a Tecnologia, Portugal