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Alexandre Dias completed the Mestrado in Mestrado in Molecular Genetics and Biomedicine in 2017 at Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia and a degree in Biochemistry in 2015 at Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia. Published 1 articles in journals. Participates and/or participated as Integration into Research Grant Fellow in 2 project(s), Master Student Fellow in 1 project(s) and Other in 1 project(s). Works in the area(s) of Natural sciences with emphasis on Biological Sciences with emphasis on Cell Biology. In their professional activities interacted with 25 collaborator(s) co-authorship of scientific papers. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Stomach; MEX3A; Wnt/ß-Catenin; Gastric Stem Cells; Gastric Organoids; Intestinal Stem Cells; LGR5; Organoids; LGR5+ intestinal stem cells; Mouse model; PPARg pathway; Intestinal homeostasis; RNA-binding protein MEX3A; SOX-2; Cancer Stem Cells; Peritoneal Carcinomatosis; Cancer; LGR5+ Gastric Stem Cells; Intestinal organoids; Inestinal Stem Cells; .
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Identification

Personal identification

Full name
Alexandre Dias

Citation names

  • Dias, Alexandre

Author identifiers

Ciência ID
751C-205E-5A80
ORCID iD
0000-0002-5110-5764

Knowledge fields

  • Natural sciences - Biological Sciences - Cell Biology
  • Medical and Health Sciences - Health Sciences - Infectious Diseases
  • Medical and Health Sciences - Basic Medicine - Pathology
  • Engineering and Technology - Nano-technology - Nano-materials

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Proficiency (C2) Advanced (C1) Proficiency (C2) Advanced (C1)
Spanish; Castilian Elementary (A2) Advanced (C1) Elementary (A2) Upper intermediate (B2)
Education
Degree Classification
2022/01/01 - 2026/01/01
Ongoing
 MCBiology (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017
Concluded
 Mestrado em Genética Molecular e Biomedicina (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Characterization of MEX3A RNA-binding protein in mouse stomach" (THESIS/DISSERTATION)
 16
2015
Concluded
 Bioquímica (Licenciatura)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Silenciamento do "Heat Shock Factor 1" (HSF1) via nanopartículas de ouro (AuNPs)" (THESIS/DISSERTATION)
 14
Affiliation

Science

Category
Host institution 		Employer
2021/01/18 - Current Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Centro Hospitalar Universitário do Porto EPE, Portugal
2017/11/01 - 2019/02/15 Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016/09 - 2017/10/31 Research Trainee (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2015/01 - 2015/06 Research Trainee (Research) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Projects

Grant

Designation Funders
2024/04/30 - 2026/04/30 PEDIASCOPE: Exploring pediatric sarcoma biomarkers with human patient-derived organoids
XXXX
Researcher
Liga Portuguesa Contra o Cancro
Ongoing
2024/01/01 - 2026/01/01 CROSSROADS: Human Cerebral Organoids as Platform for Stroke Biomarker Discovery
Bolsa Pereira Monteiro 2023
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Centro Hospitalar Universitário do Porto EPE, Portugal
Sociedade Portuguesa de Neurologia
Ongoing
2022/01/01 - 2026/01/01 Biomarkers to stratify patients and predict outcomes in brain-associated diseases, from bench to bedside
UI/BD/153607/2022
PhD Student Fellow
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Centro Hospitalar Universitário do Porto EPE, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Göteborgs universitet Sahlgrenska Akademin, Sweden

Centro Hospitalar Universitário de São João, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/18 - 2022/04/01 COVID-19 driven neurological phenotypes
Neurocovid/2021/01
Integration into Research Grant Fellow
Centro Hospitalar Universitário do Porto EPE, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade de Aveiro Instituto de Biomedicina, Portugal
Fundação Bial
Ongoing
2017/11/01 - 2019/02/15 Characterization of MEX3A RNA-binding protein in mouse stomach
NORTE-01-0145-FEDER-000029
Integration into Research Grant Fellow
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Ongoing

Contract

Designation Funders
2025/02/20 - 2026/08/19 Gastric cancer metastasis-on-a-chip (MoC) model as a predictor of metastatic patterns
2023.12556.PEX
10.54499/2023.12556.PEX
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Centro Hospitalar Universitário de São João, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2025/02/03 - 2026/08/02 Adipocyte Browning: the missing link for peritoneal metastasis in diffuse gastric cancer
2023.11680.PEX
10.54499/2023.11680.PEX
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Centro Hospitalar Universitário de São João, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/03 - 2022 BioStroke - Biomarkers for diagnosis and management of acute ischemic stroke
PTDC/MEC-NEU/31674/2017
Collaboration in the project
Centro Hospitalar Universitário do Porto EPE, Portugal

Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing

Other

Designation Funders
2022 - 2026/01/31 STROKE-SENSOR: BIOMARCADORES DE DIAGNÓSTICO E PROGNÓSTICO NO ACIDENTE VASCULAR CEREBRAL
NORTE-01-0247-FEDER-047043
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Centro Hospitalar Universitário do Porto EPE, Portugal

Göteborgs universitet Sahlgrenska Akademin, Sweden

Instituto de Biologia Molecular e Celular, Portugal
Ongoing
2016/09/12 - 2019/12 SOX2-mediated tumor heterogeneity and novel therapeutic strategies targeting cancer stem cells/relevance of tumor heterogeneity for development of strategies to inhibit peritoneal carcinomatosis.
NORTE-01-0145-FEDER-000029
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Concluded
2016/09/12 - 2017/08/31 Characterization of MEX3A RNA-binding protein in mouse stomach
Non-funded internship
Master Student Fellow
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Ongoing
Outputs

Publications

Conference abstract
  1. Moutinho, Ana; Dias, Alexandre; Luis Filipe Oliveira da Maia(9F1E-51AF-C38B). Corresponding author: Luis Filipe Oliveira da Maia(9F1E-51AF-C38B). "DESCODIFICAR O ACIDENTE VASCULAR CEREBRAL: ASSINATURAS GENÉTICAS CIRCULANTES NO PLASMA". Paper presented in 19º CONGRESSO PORTUGUÊS DO AVC, 2025.
  2. Dias, Alexandre; Luis Filipe Oliveira da Maia(9F1E-51AF-C38B). Corresponding author: Luis Filipe Oliveira da Maia(9F1E-51AF-C38B). "PERFIS DINÂMICOS DO PROTEOMA NO PLASMA DE DOENTES COM ACIDENTE VASCULAR CEREBRAL ISQUÉMICO DE ACORDO COM O PROGNÓSTICO FUNCIONAL". Paper presented in 19º CONGRESSO PORTUGUÊS DO AVC, 2025.
  3. Garcia-Pelaez, José; Dias, Alexandre; Carla Oliveira(3011-EA6C-B5A3). Corresponding author: Carla Oliveira(3011-EA6C-B5A3). "CLINICAL CRITERIA FOR CDH1 GERMLINE TESTING ACROSS DIFFERENT WORLD REGIONS: SHALL WE KEEP THEM GLOBAL?". Paper presented in 28.ª Reunião Anual da Sociedade Portuguesa de Genética Humana, 2024.
  4. Varela, Ricardo; Dias, Alexandre; Moutinho, Ana; Maia, Luís. Corresponding author: Varela, Ricardo. "Biomarcadores plasmáticos otimizam modelo de prognóstico funcional do AVC em doentes submetidos a trombectomia com sucesso". Paper presented in 17º Congresso Português do AVC, 2023.
  5. Carla Oliveira(3011-EA6C-B5A3); Quental, Rita; Dias, Alexandre. Corresponding author: Carla Oliveira(3011-EA6C-B5A3). "CHARACTERIZING HERITABLE TP53-RELATED SYNDROME IN PORTUGAL: INSIGHTS FROM THE FIRST NATIONAL COHORT". Paper presented in 27.ª Reunião Anual da Sociedade Portuguesa de Genética Humana, 2023.
  6. Silvana Lobo; Dias, Alexandre; Carla Oliveira(3011-EA6C-B5A3). "THE SOMATIC LANDSCAPE OF DIFFUSE GASTRIC CANCERS OCCURRING IN CTNNA1 GERMLINE VARIANT CARRIER PATIENTS". Paper presented in 27.ª Reunião Anual da Sociedade Portuguesa de Genética Humana, 2023.
  7. Ferreira, Daniel A.; Dias, Alexandre. Corresponding author: Ferreira, Daniel A.. "AN INSIGHT ON THE ORIGINS OF HEREDITARY DIFFUSE GASTRIC CANCER THROUGH ORGANOID DRIVEN ORGAN ON-A-CHIP TECHNOLOGY". Paper presented in 27.ª Reunião Anual da Sociedade Portuguesa de Genética Humana, 2023.
Conference poster
  1. Catarina Guedes Vaz; Dias, Alexandre; Luis Filipe Oliveira da Maia(9F1E-51AF-C38B). Corresponding author: Luis Filipe Oliveira da Maia(9F1E-51AF-C38B). "PERFIS DE microRNAs IDENTIFICAM CANCROS INCIDENTES EM DOENTES COM AVC". Paper presented in 19º CONGRESSO PORTUGUÊS DO AVC, 2025.
  2. Dias, Alexandre; Quental, Rita; Sónia Sousa; Rita Barbosa-Matos; Carla Oliveira(3011-EA6C-B5A3). Corresponding author: Carla Oliveira(3011-EA6C-B5A3). "Genotype-phenotype associations of heritable TP53-related cancers bearing loss-of-function or dominant negative pathogenic variants". Paper presented in 27.ª Reunião Anual da Sociedade Portuguesa de Genética Humana, 2023.
  3. Dias, Alexandre; Luis Filipe Oliveira da Maia(9F1E-51AF-C38B). "Biomarkers to stratify patients and predict outcomes in brain-associated diseases, from bench to bedside". Paper presented in One health PhD forum, 2023.
  4. Dias, Alexandre; Quental, Rita; Sónia Sousa; Rita Barbosa-Matos; Carla Oliveira(3011-EA6C-B5A3). Corresponding author: Carla Oliveira(3011-EA6C-B5A3). "Genotype-phenotype correlation in heritable TP53-related cancers bearing truncating and non-truncating TP53 variants". Paper presented in European Society of Human Genetics Conference 2023, 2023.
  5. Varela, Ricardo; Dias, Alexandre; Gonzalez-Ortiz, Fernando; Karikari, Thomas; Isabel Silva; Joana Fonte; Moutinho, Ana; et al. "Plasma Brain-derived tau optimizes 90-day functional outcome prediction in acute ischemic stroke". Paper presented in ESOC 2023, 2023.
  6. Nelson Eduardo Lima Martins(D915-E77F-6037); Dias, Alexandre; Carla Oliveira(3011-EA6C-B5A3). Corresponding author: Carla Oliveira(3011-EA6C-B5A3). "TUMOURS WITH CDH1 GENOMIC LOSS ASSOCIATE WITH BEST OUTCOME IN MICE AND MEN". Paper presented in 27.ª Reunião Anual da Sociedade Portuguesa de Genética Humana, 2023.
  7. Pereira B.; Dias, Alexandre; A. L. Amaral; N. Mendes; V. Muncan; A. R. Silva; C. Thibert; et al. "Mex3a deletion impairs Lgr5+ stem cell maintenance in the mouse gut". Paper presented in ISSCR International Symposium 2019: Stem cells and Organoids in Development and Disease, 2019.
  8. Dias, Alexandre; Amaral A. L.; Almeida, Raquel; Pereira B.. "Characterization of MEX3A RNA-binding protein in the mouse stomach.". Paper presented in VIII National RNA meeting: ptRNA, 2019.
  9. Dias, Alexandre; A. L. Amaral; Almeida, Raquel; Pereira B.. "Characterization of MEX3A RNA-binding protein in the mouse stomach.". Paper presented in i3S 7th Annual Meeting 2018, 2018.
  10. Pereira B.; Dias, Alexandre; A. L. Amaral; V. Muncan; A. R. Silva; C. Thibert; A. G. Radu; et al. "MEX3A regulates Lgr5+ stem cell maintenance in the developing intestinal epithelium". Paper presented in i3S 7th Annual Meeting 2018, 2018.
Journal article
  1. Ricardo Varela; Fernando Gonzalez-Ortiz; Alexandre Dias; Nicoló Luca Knuth; Joana Fonte; Beatriz Pinto; Idil Yuksekel; et al. "Plasma Brain-Derived Tau in Prognosis of Large Vessel Occlusion Ischemic Stroke". Stroke (2024): https://doi.org/10.1161/STROKEAHA.123.046117.
    10.1161/STROKEAHA.123.046117
  2. Lobo, S.; Dias, A.; Ferreira, M.; Herrera-Mullar, J.; Svrcek, M.; Hueneburg, R.; Moreira, L.; et al. "18P The role of CTNNA1 truncating variants in hereditary diffuse gastric cancer (HDGC)". Annals of Oncology 35 (2024): S220. https://doi.org/10.1016/j.annonc.2024.08.027.
    10.1016/j.annonc.2024.08.027
  3. Cavaco, Sara; Sousa, Gabriela; Gonçalves, Ana; Dias, Alexandre; Andrade, Carlos; Pereira, Diogo; Aires, Elaine Araújo; et al. "Predictors of cognitive dysfunction one-year post COVID-19.". Neuropsychology 37 5 (2023): 557-567. http://dx.doi.org/10.1037/neu0000876.
    10.1037/neu0000876
  4. Gonzalez-Ortiz, Fernando; Dias, Alexandre; Turton, Michael; Magalhães, Rui; Kac, Przemyslaw R.; Correia, Manuel; Harrison, Peter; et al. "Preanalytical stability of plasma/serum brain-derived tau". Alzheimer's & Dementia 19 10 (2023): 4764-4770. http://dx.doi.org/10.1002/alz.13156.
    10.1002/alz.13156
  5. Alexandre Dias; José Garcia-Pelaez; Rita Barbosa-Matos; Silvana Lobo; Luzia Garrido; Sérgio Castedo; Sónia Sousa; et al. "Genotype-first approach to identify associations between CDH1 germline variants and cancer phenotypes: a multicentre study by the European Reference Network on Genetic Tumour Risk Syndromes". The Lancet Oncology (2022): http://dx.doi.org/10.1016/s1470-2045(22)00643-x.
    10.1016/s1470-2045(22)00643-x
  6. Alexandre Dias; Lénia Silva; João Moura; Denis Gabriel; Luis F. Maia. "Fluid biomarkers in stroke: From animal models to clinical care". Acta Neurologica Scandinavica (2022): https://doi.org/10.1111/ane.13668.
    10.1111/ane.13668
  7. Saba Abdulghani; Ângela Afonso; Mireia Castillo-Martin; Javier Martín-Fernández; Inês Franco; Parreira B.; Ana Rita Couto; et al. "The Role of Biobanks in the Fight against COVID-19 Pandemic: The Portuguese Response". Acta Médica Portuguesa 35 6 (2022): 411-415. http://dx.doi.org/10.20344/amp.17856.
    10.20344/amp.17856
  8. Ettore Beghi. "Short- and long-term outcome and predictors in an international cohort of patients with neuro-COVID-19". European journal of neurology (2022):
    Open access • Published • Assistant staff
  9. Alexandre Dias; Isabel Silva; Inês Mendes Pinto; Luís F. Maia. "Timely and Blood-Based Multiplex Molecular Profiling of Acute Stroke". Life 11 8 (2021): 816-816. https://doi.org/10.3390/life11080816.
    Open access • 10.3390/life11080816
  10. Pereira, Bruno; Amaral, Ana L; Dias, Alexandre; Mendes, Nuno; Muncan, Vanesa; Silva, Ana R; Thibert, Chantal; et al. "MEX3A regulates Lgr5 + stem cell maintenance in the developing intestinal epithelium". EMBO reports 21 4 (2020): http://dx.doi.org/10.15252/embr.201948938.
    Open access • Published • 10.15252/embr.201948938
Preprint
  1. Tiago Gião; Miguel Tábuas-Pereira; Inês Baldeiras; Joana Saavedra; Alexandre Dias; Maria João Saraiva; Maria Rosário Almeida; Isabel Santana; Isabel Cardoso. "Transthyretin Levels and Instability in Alzheimer’s Disease: Correlations with AD Biomarkers in a Cohort Study". 2025. https://doi.org/10.1101/2025.01.24.634710.
    10.1101/2025.01.24.634710
  2. Dias, Alexandre; Oliveira, Vanessa; Aires, Elaine; Silva, Lénia; Gonçalves, Ana; Pereira, Diogo; Cavaco, Sara; et al. "The Spectrum of Post-COVID Neurological Syndrome: A Prospective Cohort Study". 2022. http://dx.doi.org/10.2139/ssrn.4153451.
    10.2139/ssrn.4153451
Activities

Ad Hoc journal article review

Journal title (ISSN) Publisher
2025/04 - 2025/04 Frontiers in Neurology (1664-2295) Frontiers Media SA
2024/08/27 - 2024/08/27 Discover Oncology
2021/02/01 - 2021/02/06 European Journal of Neurology

Mentoring / Tutoring

Topic Student name
2016/10 - 2017/04 Integration of a Biology undergraduate student into the lab. Andreia Sofia da Cunha Augusto
Distinctions

Other distinction

2024 Honor Mention from Premio Rui Osorio de Castro Millennium bcp
Millennium bcp, Portugal
2023 Poster Highlight
Sociedade Portuguesa de Genética Humana, Portugal