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Filipa Lebre. Completed the Mestrado integrado in Ciências Farmacêuticas in 2008 by Universidade de Coimbra and Doutoramento in Doutoramento em Tecnologia Farmacêutica in 2017 by Universidade de Coimbra Faculdade de Farmácia. Is Researcher in International Iberian Nanotechnology Laboratory. Published 16 articles in journals. Has 1 book(s). Organized 3 event(s). Participated in 27 event(s). Co-supervised 5 work(s) of course completion of LSc/BSc. Has received 3 awards and/or honors. Participates and/or participated as Co-Principal Investigator (Co-PI) in 1 project(s), Post-doc Fellow in 1 project(s), Principal investigator in 1 project(s) and Researcher in 1 project(s). Works in the area(s) of Medical and Health Sciences with emphasis on Medical Biotechnology with emphasis on Biomaterials, Medical and Health Sciences with emphasis on Basic Medicine with emphasis on Immunology, Medical and Health Sciences with emphasis on Medical Biotechnology with emphasis on Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism and Medical and Health Sciences with emphasis on Medical Biotechnology with emphasis on Health-Related Biotechnology. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: nanoparticles; vaccines; chitosan; hepatitis B antigen; DNA; mucosal vaccination; nasal administration; adjuvant association; Domínio/Área Científica::Ciências Médicas::Ciências da Saúde; .
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Identification

Personal identification

Full name
Filipa Lebre

Citation names

  • Lebre, Filipa

Author identifiers

Ciência ID
7017-F931-4DE5
ORCID iD
0000-0003-3146-269X
Google Scholar ID
https://scholar.google.com/citations?user=uEqlV6wAAAAJ&hl=en
Scopus Author Id
36480377300

Email addresses

  • filipa.lebre@inl.int (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Biomaterials
  • Medical and Health Sciences - Basic Medicine - Immunology
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Beginner (A1) Intermediate (B1) Beginner (A1) Intermediate (B1)
Spanish; Castilian Beginner (A1) Intermediate (B1) Beginner (A1) Intermediate (B1)
Education
Degree Classification
2023/03/30
Concluded
 Data Integrity and Good Documentation Practices (Outros)
Qualipharma, Spain
2023/03/23
Concluded
 Deviations, CAPAs & Change Controls (Outros)
Qualipharma, Spain
2022/11/29 - 2022/11/29
Concluded
 Good Laboratory Practices (GLP) (Outros)
Qualipharma, Spain
2019
Concluded
 Epigeum training (Outros)
Epigeum, United Kingdom
 Aprovado
2010 - 2017
Concluded
 Doutoramento em Tecnologia Farmacêutica (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
"Development of chitosan-based nanoparticles for nasal immunization against hepatitis B" (THESIS/DISSERTATION)
 Aprovado com Distinção e Louvor
2016
Concluded
 LAST Ireland - Animal surgery course (Outros)
University College Dublin, Ireland
2012/09/01 - 2013/03/31
Concluded
 Visiting PhD student, Trinity Biomedical Sciences Institute (Outros)
The University of Dublin Trinity College, Ireland
2012
Concluded
 Vaccine Immunology with Exploration of Immune Response to Mucosal Vaccines (Outros)
Universidade de Coimbra, Portugal
2011
Concluded
 Laboratory Animal Science Course - Cat C (FELASA). (Outros)
Institute for Molecular and Cell Biology, Portugal
2010/05/01 - 2010/06/30
Concluded
 Visiting PhD student (Outros)
Ecole de Pharmacie Gèneve-Lausanne, Switzerland
2010
Concluded
 MIT Principles and Practice of Drug Development (Outros)
Center of Neuroscience and Cell Biology, Portugal
2003 - 2008
Concluded
 Ciências Farmacêuticas (Mestrado integrado)
Universidade de Coimbra, Portugal
"Não aplicável" (THESIS/DISSERTATION)
 15 valores
Affiliation

Science

Category
Host institution 		Employer
2021/11/02 - Current Researcher (Research) International Iberian Nanotechnology Laboratory, Portugal
2019/06 - 2020/11/30 Principal Investigator (Research) Science Foundation Ireland, Ireland
2017/10 - 2019/05 Postdoc (Research) Trinity College of Dublin, Ireland
2014/05 - 2017/09 Research Assistant (Research) The University of Dublin Trinity College, Ireland
2010/05 - 2014/04 Researcher (Research) Universidade de Coimbra, Portugal
2010/05 - 2014/04 Researcher (Research) Center of Neuroscience and Cell Biology, Portugal
Projects

Contract

Designation Funders
2021/11 - 2025/01 SiNfONiA
857253
Researcher
International Iberian Nanotechnology Laboratory, Portugal
 Horizon 2020
Ongoing
2022 - 2022 Development of advanced 3D in vitro alveolar model and application for nanosafety screening
2022.07049.PTDC
Co-Principal Investigator (Co-PI)
Not funded
2019/06/01 - 2020/11/30 Bioactive Drug Incorporation into 3D Bioprinted Scaffolds for Oncological Application
18/IF/6316
Principal investigator
Johnson & Johnson 3D Bioprinting Center, Ireland
 Science Foundation Ireland
Concluded
2014/05 - 2019/06 Advanced Materials and BioEngineering Research Centre (AMBER)
SFI/12/RC/2278
Post-doc Fellow
Trinity College of Dublin, Ireland
Concluded
Outputs

Publications

Book
  1. Lebre, F.; Bento, D.; Jesus, S.; Borges, O.; Lebre, Filipa; Bento, Dulce; Jesus, Sandra; Borges, Olga. Chitosan-Based Nanoparticles as a Hepatitis B Antigen Delivery System. Academic Press: Elsevier. 2012.
    Published • 10.1016/B978-0-12-391858-1.00007-1
Conference abstract
  1. Lebre, Filipa; Lima, Maria Conceição Pedroso; Borges, Olga. "Immunogenicity of a DNA based Hepatitis B vaccine". Paper presented in 9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Lisbon, 2014.
    Published
  2. Lebre, Filipa; Pedroso de Lima, M. C.; Lavelle, Ed C.; Lima, Maria Conceição Pedroso. "Vaccines: Mechanisms of chitosan nanoparticle adjuvancy partially revealed". Paper presented in XXXVIII Annual Meeting of the Portuguese Society of Immunology, Coimbra, 2014.
    Published
  3. Lebre, Filipa; Borchard, Gerrit; Faneca, Henrique; Lima, Maria Conceição Pedroso; Borges, Olga. "Albumin loaded chitosan nanoparticles/DNA complexes for nasal immunization". Paper presented in AAPS National Biotechnology Conference "Advancing health through innovations in biotherapeutics", San Diego, 2012.
    Published
  4. Jesus, Sandra; Bento, Dulce; Lebre, Filipa; Borchard, Gerrit; Borges, Olga. "Understanding the adsorption mechanism of model antigens onto chitosan-based particles". Paper presented in 38th Annual Meeting & Exposition of the Controlled Release Society, Maryland, 2011.
    Published
  5. Jesus, Sandra; Bento, Dulce; Lebre, Filipa; Borchard, Gerrit; Borges, Olga. "Comparison of the adsorption of different model proteins to chitosan-based particles". Paper presented in III Congress of the Portuguese Society of Pharmaceutical Sciences and IX Spanish-Portuguese Conference on Controlled Drug Delivery - New Trends in Pharmaceutical Sciences, Porto, 2011.
    Published
  6. Lebre, Filipa; Borchard, Gerrit; Faneca, Henrique; Lima, Maria Conceição Pedroso; Borges, Olga. "Development of chitosan nanoparticle-DNA complexes for nasal immunization against hepatitis B". Paper presented in 4th BBBB - Bled International Conference on Pharmaceutical Sciences, Bled, 2011.
    Published
  7. Lebre, Filipa; Borchard, Gerrit; Lima, Maria Conceição Pedroso; Borges, Olga. "Development of chitosan nanoparticle-DNA complexes for nasal immunization against hepatitis B - Preliminary results". Paper presented in Modern Vaccines/Adjuvants Formulations, Cannes, 2010.
    Published
  8. Borges, Olga; Lebre, Filipa; Borchard, Gerrit; Junginger, Hans E.. "Model vaccine release profile from different chitosan-based nanoparticles". Paper presented in 35th Annual Meeting & Exposition of the Controlled Release Society, New York, 2008.
    Published
Conference paper
  1. Lebre, Filipa; Rukmani Sridharan; Michael Sawkins; Daniel Kelly; Fergal O'Brien; Lavelle, Ed C.. "Hydroxyapatite particle size controls the induction of inflammatory responses suggesting the need to specifically tailor particle size for the development of regenerative implants". Paper presented in Irish Society for Immunology meeting, Dublin, 2015.
    Published
  2. Lebre, Filipa; Rukmani Sridharan; Michael Sawkins; Daniel Kelly; Fergal O'Brien; Lavelle, Ed C.. "Immunomodulatory properties of hydroxyapatite particles". Paper presented in AMBER review, Dublin, 2015.
    Published
  3. Bento, Dulce; Lebre, Filipa; Ed Lavelle; Herman Staats; Lima, Maria Conceição Pedroso; Borges, Olga. "Chitosan combined with immunopotentiators as vaccine adjuvants: Are there any advantages?". Paper presented in 7th Vaccine and ISV Annual Congress, Barcelona, 2013.
    Published
Journal article
  1. S. Costa; V. Vilas-Boas; F. Lebre; J.M. Granjeiro; C.M. Catarino; L. Moreira Teixeira; P. Loskill; E. Alfaro-Moreno; A.R. Ribeiro. "Microfluidic-based skin-on-chip systems for safety assessment of nanomaterials". Trends in Biotechnology (2023): http://dx.doi.org/10.1016/j.tibtech.2023.05.009.
    10.1016/j.tibtech.2023.05.009
  2. Lebre, Filipa; Chatterjee, Nivedita; Costa, Samantha; Fernández-de-Gortari, Eli; Lopes, Carla; Meneses, João; Ortiz, Luís; et al. "Nanosafety: An Evolving Concept to Bring the Safest Possible Nanomaterials to Society and Environment". Nanomaterials 12 11 (2022): 1810. http://dx.doi.org/10.3390/nano12111810.
    10.3390/nano12111810
  3. Lundahl, Mimmi; Lynch, Dylan M.; Barnes, Danielle; McSweeney, Lauren; Gorman, Aoife; Lebre, Filipa; Gordon, Stephen V.; Lavelle, Ed C.; Scanlan, Eoin M.. "Mycobacterial para Hydroxybenzoic Acid-Derivatives (pHBADs) and Related Structures Induce Macrophage Innate Memory". ACS Chemical Biology (2020): http://dx.doi.org/10.1021/acschembio.0c00378.
    10.1021/acschembio.0c00378
  4. Shears, R.K.; Jacques, L.C.; Naylor, G.; Miyashita, L.; Khandaker, S.; Lebre, F.; Lavelle, E.C.; et al. "Exposure to diesel exhaust particles increases susceptibility to invasive pneumococcal disease". Journal of Allergy and Clinical Immunology 145 4 (2020): 1272-1284.e6. http://www.scopus.com/inward/record.url?eid=2-s2.0-85082558281&partnerID=MN8TOARS.
    10.1016/j.jaci.2019.11.039
  5. Lebre, F.; Boland, J.B.; Gouveia, P.; Gorman, A.L.; Lundahl, M.L.E.; I Lynch, R.; O'Brien, F.J.; Coleman, J.; Lavelle, E.C.. "Pristine graphene induces innate immune training". Nanoscale 12 20 (2020): 11192-11200. http://www.scopus.com/inward/record.url?eid=2-s2.0-85085586320&partnerID=MN8TOARS.
    Published • 10.1039/c9nr09661b
  6. Lebre, Filipa. "Easy and effective method to generate endotoxin-free chitosan particles for immunotoxicology and immunopharmacology studies". Journal of Pharmacy and Pharmacology (2019): http://dx.doi.org/10.1111/jphp.13082.
    10.1111/jphp.13082
  7. Lebre, Filipa. "Chitosan Plus Compound 48/80: Formulation and Preliminary Evaluation as a Hepatitis B Vaccine Adjuvant". Pharmaceutics (2019): http://dx.doi.org/10.3390/pharmaceutics11020072.
    10.3390/pharmaceutics11020072
  8. Lebre, Filipa. "Exfoliation in Endotoxin-Free Albumin Generates Pristine Graphene with Reduced Inflammatory Properties". Advanced Biosystems (2018): http://dx.doi.org/10.1002/adbi.201800102.
    10.1002/adbi.201800102
  9. Lebre, F.; Pedroso de Lima, M.C.; Lavelle, E.C.; Borges, O.. "Mechanistic study of the adjuvant effect of chitosan-aluminum nanoparticles". International Journal of Pharmaceutics 552 1-2 (2018): 7-15. http://www.scopus.com/inward/record.url?eid=2-s2.0-85053833190&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2018.09.044
  10. Moore, Caroline; Movia, Dania; Smith, Ronan J; Hanlon, Damien; Lebre, Filipa; Lavelle, Ed C.; Byrne, Hugh J; et al. "Industrial grade 2D molybdenum disulphide (MoS2): an in vitro exploration of the impact on cellular uptake, cytotoxicity, and inflammation". 2D Materials 4 2 (2017): 025065-025065.
    Published • 10.1088/2053-1583/aa673f
  11. Lebre, F.; Sridharan, R.; Sawkins, M.J.; Kelly, D.J.; O'Brien, F.J.; Lavelle, E.C.; Lebre, Filipa; et al. "The shape and size of hydroxyapatite particles dictate inflammatory responses following implantation". Scientific Reports 7 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85020432907&partnerID=MN8TOARS.
    Published • 10.1038/s41598-017-03086-0
  12. Lebre, F.; Bento, D.; Ribeiro, J.; Colaço, M.; Borchard, G.; Pedroso De Lima, M.C.P.; Borges, O.; Lebre, Filipa. "Association of chitosan and aluminium as a new adjuvant strategy for improved vaccination". International Journal of Pharmaceutics 527 1-2 (2017): 103-114. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019758926&partnerID=MN8TOARS.
    Published • 10.1016/j.ijpharm.2017.05.028
  13. Lebre, Filipa; Hearnden, Claire H.; Lavelle, Ed C.. "Modulation of Immune Responses by Particulate Materials". Advanced Materials 28 27 (2016): 5525-5541.
    Published • 10.1002/adma.201505395
  14. Lebre, F.; Borchard, G.; Faneca, H.; Pedroso de Lima, M. C.; Borges, O.. "Intranasal Administration of Novel Chitosan Nanoparticle/DNA Complexes Induces Antibody Response to Hepatitis B Surface Antigen in Mice". Molecular Pharmaceutics 13 2 (2016): 472-482.
    Published • 10.1021/acs.molpharmaceut.5b00707
  15. Lebre, Filipa; Borchard, Gerrit; Lima, Maria Conceição Pedroso; Borges, Olga. "Progress Towards a Needle-Free Hepatitis B Vaccine". Pharmaceutical Research 28 5 (2010): 986-1012.
    Published • 10.1007/s11095-010-0314-4
  16. Borges, Olga; Lebre, Filipa; Bento, Dulce; Borchard, Gerrit; Junginger, Hans E.. "Mucosal Vaccines: Recent Progress in Understanding the Natural Barriers". Pharmaceutical Research 27 2 (2009): 211-223.
    Published • 10.1007/s11095-009-0011-3
Preprint
  1. Lundahl, Mimmi LE; Mitermite, Morgane; Ryan, Dylan G; Case, Sarah; Williams, Niamh C; Yang, Ming; Lynch, Roisin I; et al. "Macrophage Innate Training Induced by IL-4 and IL-13 Activation Enhances OXPHOS Driven Anti-Mycobacterial Responses". 2021. http://dx.doi.org/10.1101/2021.10.12.463833.
    10.1101/2021.10.12.463833
Thesis / Dissertation
  1. Lebre, Filipa Raquel Maia Fontes. "Development of chitosan-based nanoparticles for nasal immunization against hepatitis B". PhD, 2017. http://hdl.handle.net/10316/41058.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021 Immunomodulation by Nanomaterials Total-Nanosafe
International Iberian Nanotechnology Laboratory (Braga, Portugal)
2017 The Shape and Size of Hydroxyapatite Particles Dictate Inflammatory Responses Following Implantation 6th China-Europe Symposium on Biomaterials and Regenerative Medicine
(Porto, Portugal)
2016 Hydroxyapatite particle size controls the induction of inflammatory responses suggesting the need to specifically tailor particle size for the development of regenerative implants E-MRS 2016 Spring Meeting
European Materials Research Society (Lille, France)
2016 Size regulates the immune responses triggered by hydroxyapatite particles Ireland-Japan Biomaterials & Tissue Engineering Meeting
(Galway, Ireland)
2016 Tailoring hydroxyapatite particle physicochemical properties to optimise the immunomodulatory properties of regenerative implants
(Galway, Ireland)
2015 In vitro and in vivo model systems to explore the interaction between biomaterials and the immune system Next generation medical device research theme
(Ireland)
2013 Nanoparticulas de quitosano: mais que um sistema de entrega? FFUC Seminar
(Coimbra, Portugal)
2013 Chitosan nanoparticles: more than a delivery system? CNC Seminar
CNC (Coimbra)
2013 Nanotechnologies in biomedicine Seminar
Faculty of Medicine in Hradec Kralove (Hradec Kralove, Czech Republic)
2012 Development of chitosan-based nanoparticles for nasal immunization against hepatitis B Short course "Vaccine Immunology with Exploration of Immune Response to Mucosal Vaccines
(Coimbra)
2011 Association of different immunopotentiators as promising mucosal adjuvants in future 4th International Conference on Immunopotentiators in Modern Vaccines
(Porto)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2018 - 2019 Evaluation of the mechanism of trained immunity by pristine graphene
Co-supervisor
Trinity College of Dublin, Ireland
2017 - 2018 Exploring the immunomodulatory properties of nanosized graphene flakes for tailoring biomedical applications
Co-supervisor
Trinity College of Dublin, Ireland
2016 - 2016 Poly (D,L-Lactide-co-glycolide)-based vaccines against autoimmune diseases
Co-supervisor
Trinity College of Dublin, Ireland
2015 - 2016 Immune cell activation using porous nanoparticles to target immunomodulators.
Co-supervisor
Trinity College of Dublin, Ireland
2014 - 2014 The role of surface chemistry in inflammasome activation by particulate vaccine adjuvants
Co-supervisor
Trinity College of Dublin, Ireland

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2021/11/11 - 2021/11/12 TOTAL-NANOSAFE:: From Molecules to Public Health (2021/11/11 - 2022/11/12)
Conference (Member of the Organising Committee)
 International Iberian Nanotechnology Laboratory, Portugal
2011 - 2011 Vaccines and adjuvants: from antigen production to modulation of antigen-specific immune response
Symposium (Other)
2009 - 2009 2nd practical training course on chitosan nanoparticles as antigen delivery system for mucosal vaccination
Workshop (Other)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2022/06/20 - 2022/06/21 INL Summit 2022/ Transitions
Other
International Iberian Nanotechnology Laboratory, Portugal
2021/06/20 - 2021/06/23 European Technology Platform on Nanomedicine (ETPN), 17th annual event
2018/11/26 - 2018/12/01 Transition Year Students Program. Series of workshops.
Workshop
 TY Program
Trinity College of Dublin, Ireland
2018/07/11 - 2018/07/12 Workshops about research project management, how you function in teams, understanding industry and communicating your science.
Workshop
 EDGE Bootcamp
2018/02/26 - 2018/03/02 Transition Year Students Program. Series of workshops.
Workshop
 TY Program
The University of Dublin Trinity College, Ireland
2018 - 2018 Irish Society for Immunology Meeting
Congress
2017 - 2017 Irish Society for Immunology Meeting
Congress
2016 - 2016 Powder Technology Seminar
Congress
2016 - 2016 Institute of Animal Technology Irish Branch Symposium. Dublin
Congress
2016 - 2016 TBSI Postdoctoral Research Day
Congress
2016 - 2016 Exploring the Microbe–Immune System Interface, Microbiology Society Irish Division and Irish Society of Immunology Focused Meeting
Congress
2016 - 2016 E-MRS Spring Meeting
Congress
2016 - 2016 Irish Society for Immunology Meeting
Conference
2015/09/25 - 2015/09/25 Volunteer. EU Researchers’ Nights are public events committed to bringing researchers closer to the public. Discover Research Night
The University of Dublin Trinity College, Ireland
2015/03/02 - 2015/03/06 Transition Year students week. Series of Workshops. Allow 15 15/16 year olds come into CRANN for a week and experience what it is like to be a scientist.
Workshop
 TY Week
Centre for Research on Adaptive Nanostructures and Nanodevices, Ireland
2015 - 2015 Irish Society for Immunology Meeting
Congress
2015 - 2015 Radiation Protection Workshop
Workshop
2015 - 2015 Science Foundation Ireland Early Career Researcher Forum
Meeting
2014 - 2014 Irish Society for Immunology Meeting
Congress
2014 - 2014 Chemical Safety Workshop
Workshop
2014 - 2014 Biological Safety Workshop
Congress
2013 - 2013 XXXIX Annual Meeting of the Portuguese Society of Immunology
Congress
2012 - 2012 AAPS National Biotechnology Conference. San Diego,
Congress
2012 - 2012 Irish Society for Immunology Meeting
Congress
2011 - 2011 III Congress of the Portuguese Society of Pharmaceutical Sciences and IX Spanish-Portuguese Conference on Controlled Drug Delivery
Congress
2011 - 2011 4th BBBB - Bled International Conference on Pharmaceutical Sciences
Congress
2010 - 2010 Modern Vaccines/Adjuvants Formulations
Congress

Association member

Society Organization name Role
2014 - Current Irish Society for Immunology
2012/05 - Current American Association of Pharmaceutical Scientists
2013 - 2014 Sociedade Portuguesa de Imunologia
2009 - 2014 Ordem dos Farmacêuticos

Mentoring / Tutoring

Topic Student name
2012 - 2012 Marcela Oliveira
2012 - 2012 Marta Sintra
2011 - 2011 Ana Lúcia Agostinho
2010 - 2010 Sandra Jesus
2009 - 2009 Sofia Valdeira
Distinctions

Other distinction

2019 SFI Industry Fellowship - 18/IF/6316
Science Foundation Ireland, Ireland
2010 PhD fellowship - SFRH/BD/64046/2009
Portuguese Foundation for Science and Technology, Portugal
2009 Bolsa de Investigação para apoio a Doutoramento no âmbito da Patologia Infecciosa
GlaxoSmithKline Portuguese Foundation, Portugal