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Formação Académica: Mestrado integrado em Medicina (2005-2011) e Pós-graduação em Genética e Genómica (2020-2021) pela Faculdade de Ciências Médicas da Universidade Nova de Lisboa; Pós-graduação em Geriatria (2015-2016) pela Faculdade de Medicina da Universidade de Coimbra. Aprovado no exame da ESMO (European Society for Medical Oncology) 2018. Atividade Clínica: Assistente Hospitalar de Oncologia Médica no Centro Hospitalar e Universitário de Coimbra EPE (CHUC) desde 2019. Desenvolve a sua atividade assistencial na área dos Tumores do Sistema Digestivo e Cancro de Pele. Esteve na génese do Grupo Multidisciplinar de Tumores Neuroendócrinos Gastroenteropancreáticos e do Grupo Multidisciplinar de Cancro de Pele do CHUC. Estágio Observacional no MD Anderson Cancer Center (Houston-Texas) em Melanoma Medical Oncology - Research (2018). Assistente convidado da Faculdade de Medicina da Universidade de Coimbra desde 2022. Publicou 8 artigos em revistas especializadas. Investigador Principal/Co-investigador em 4 ensaios clínicos fase III. Preletor em vários cursos com temas dedicados a várias áreas de patologia oncológica.
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Identification

Personal identification

Full name
Edgar André Carvalho Pratas

Citation names

  • Pratas, E.
  • Pratas, Edgar

Author identifiers

Ciência ID
7017-4039-5331
ORCID iD
0000-0001-9635-4505

Addresses

  • Serviço de Oncologia Médica, Unidade Local de Saúde (ULS) de Coimbra , Praceta Professor Mota Pinto, 3004-561 , Coimbra, Coimbra, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences - Clinical Medicine - Oncology
  • Medical and Health Sciences - Clinical Medicine - Geriatrics and Gerontology
  • Natural sciences - Biological Sciences - Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Elementary (A2) Intermediate (B1) Elementary (A2)
French Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2)
Education
Degree Classification
2022/09 - 2027/09
Ongoing
 Medicina (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2022/04
Concluded
 How to develop a systematic review protocol (Outros)
Cochrane Sweden, Sweden
 Aprovado
2020 - 2021
Concluded
 Genética e Genómica para Clínicos (Pós-Graduação)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
 18
2018/10/20
Concluded
 ESMO EXAMINATION CERTIFICATE (Outros)
Major in Oncologia Médica
European Society for Medical Oncology, Switzerland
 Aprovado
2018/08 - 2018/10
Attended
 Melanoma Medical Oncology - Research (Outros)
The University of Texas MD Anderson Cancer Center, United States
2015 - 2016
Concluded
 Geriatria (Pós-Graduação)
Universidade de Coimbra Faculdade de Medicina, Portugal
 16
2005 - 2011
Concluded
 Medicina (Mestrado integrado)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
 15
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2022 - Current Invited Assistant (University Teacher) Universidade de Coimbra Faculdade de Medicina, Portugal

Other Careers

Category
Host institution 		Employer
2019 - Current Assistente (Médica) Centro Hospitalar e Universitário de Coimbra EPE, Portugal
2014 - 2018 Interno (Médica) Instituto Português de Oncologia de Coimbra Francisco Gentil EPE, Portugal
Projects

Other

Designation Funders
2024 - Current AZUR-2, a phase III, open-label, randomized study of perioperative dostarlimab monotherapy vs standard of care in previously untreated patients with T4N0 or stage III dMMR/MSI-H resectable colon cancer.
AZUR-2
Researcher
2024 - Current An open-label randomized trial of the efficacy and safety of zanidatamab with standard-of-care therapy against standard-of-care therapy alone for advanced HER2-positive biliary tract cancer
JZP598-302
Researcher
2023 - Current A Randomized, Open-Label, Multicenter Phase 3 Trial of Domvanalimab, Zimberelimab, and Chemotherapy Versus Nivolumab and Chemotherapy in Participants with Previously Untreated Locally Advanced Unresectable or Metastatic Gastric, Gastroesophageal Junction, and Esophageal Adenocarcinoma (STAR 221)
STAR-221
Researcher
2022 - Current A Randomized, Multicenter, Phase 3 Study of Zanidatamab in Combination with Chemotherapy with or without Tislelizumab in Subjects with HER2-positive Unresectable Locally Advanced or Metastatic Gastroesophageal Adenocarcinoma (HERIZON)
ZWI-ZW25-301
Researcher
2022 - Current A Randomized, Multi-center, Double-blind, Placebo-controlled Phase 3 Study of Bemarituzumab plus Chemotherapy versus Placebo plus Chemotherapy in Subjects with Previously Untreated Advanced Gastric or Gastroesophageal Junction Cancer with FGFR2b Overexpression (FORTITUDE-101)
FORTITUDE-101
Researcher
2021 - Current A Study of Atezolizumab With or Without Tiragolumab in Participants With Unresectable Esophageal Squamous Cell Carcinoma Whose Cancers Have Not Progressed Following Definitive Concurrent Chemoradiotherapy (SKYSCRAPER-07)
NCT04543617
Researcher
F Hoffmann-La Roche AG, Switzerland
Ongoing
2019 - 2021 Phase III Study in First-line Treatment of Patients With Metastatic Colorectal Cancer Who Are Not Candidate for Intensive Therapy. (SOLSTICE)
NCT03869892
Researcher
Institut Servier SAS, France
2018 - 2019 Study To Compare Avelumab In Combination With Standard of Care Chemoradiotherapy (SoC CRT) Versus SoC CRT for Definitive Treatment In Patients With Locally Advanced Squamous Cell Carcinoma Of The Head And Neck (JAVELIN HEAD AND NECK 100)
NCT02952586
Researcher
Outputs

Publications

Book chapter
  1. Pratas, Edgar. "Tumores da Bexiga - Terapêutica Médica". In Manual do Interno de Urologia. Portugal: Grupo Português Genito-Urinário, 2019.
    Published
Conference poster
  1. Pratas, Edgar. "Early changes in immune cell populations after anti-pd1 treatment of melanoma". Paper presented in 18th European Association of Dermato-Oncology Congress, 2022.
  2. Domingues, I.; Carvalho, J.; Pratas, E.A.; Pinheiro, S.; Amaral, S.; Pereira, T.; Pontes, F.; et al. "Illness perceptions, quality of life and mood in metastatic breast cancer patients". Paper presented in 44th ESMO Congress (ESMO 2019), 2019.
    10.1093/annonc/mdz242.070
  3. Rego, I.; Pontes, F.; Carvalho, J.; Pratas, E.; Chaves, A.; Martins, R.; Couto, J.; et al. "A single center experience with oral chemotherapy with capecitabine and temozolomide in metastatic neuroendocrine tumors". Paper presented in ESMO 21st World Congress on Gastrointestinal Cancer, 2019.
    10.1093/annonc/mdz155.345
  4. Domingues, I.; Carvalho, J.; Pratas, E.; Pinheiro, S.; Amaral, S.; Bonito, N.; Jesus, E.; et al. "A long-term analysis of imatinib palliative treatment in gastrointestinal stromal tumors". Paper presented in ESMO 20th World Congress on Gastrointestinal Cancer, 2018.
    10.1093/annonc/mdy151.115
  5. Amaral, S.; Garcia, R.; Pratas, E.; Domingues, I.; Sobrinho, J.; Pinheiro, S.; Mariano, M.; Madeira, P.; Sousa, G.. "Does sunitinib-induced hypothyroidism correlate with better outcomes in metastatic renal cell carcinoma?". Paper presented in 10th European Multidisciplinary Congress on Urologic Cancers - EMUC 2018, 2018.
    10.1016/s1569-9056(18)33796-5
  6. Pratas, Edgar. "Adenocarcinoma do Pulmão Estadio IV, Overview". Paper presented in 14º Congresso Nacional de Oncologia, 2017.
  7. Pratas, Edgar. "Carcinoma do Pulmão de Pequenas Células Estadio IV, Análise Retrospectiva de Uma Instituição". Paper presented in 14º Congresso Nacio- nal de Oncologia, 2017.
Journal article
  1. D. Marques; A.-L. Costa; A. Mansinho; A. Quintela; E. Pratas; J. Brito-Silva; J. Fereira-Cruz; et al. "The REWRITE Study – REal-WoRld effectIveness of TrifluridinE/tipiracil in Patients with Previously Treated Metastatic Colorectal Cancer". Clinical Oncology (2023): https://doi.org/10.1016/j.clon.2023.07.004.
    10.1016/j.clon.2023.07.004
  2. Pratas, Edgar; Carvalho, João; Domingues, Isabel; Pinheiro, Sara; Amaral, Susana; Khouri, Leila; Costa, Miguel; et al. "Case Report: Sarcoidosis mimicking head and neck cancer progression". F1000Research 8 (2019): 215. http://dx.doi.org/10.12688/f1000research.17834.1.
    10.12688/f1000research.17834.1
  3. Domingues, Isabel; Aroso, Pedro; Goncalves, Mariana; Pratas, Edgar; Carvalho, Joao; Pinheiro, Sara; Breda, Filipe; Santos, Lelita. "A Rare Case of Pericarditis due to Listeria monocytogenes 1/2a and 4b Serotypes". Journal of Medical Cases 10 2 (2019): 49-52. http://dx.doi.org/10.14740/jmc3244.
    10.14740/jmc3244
  4. Pratas, Edgar; Carvalho, João; Domingues, Isabel; Fonseca, João; Carvalho, Teresa; Sousa, Gabriela; Veríssimo, Manuel Teixeira. "Remitting Seronegative Symmetrical Synovitis with Pitting Oedema as the First Manifestation of an Adenocarcinoma of the Caecum". European Journal of Case Reports in Internal Medicine 5 12 (2018): 1. http://dx.doi.org/10.12890/2018_000976.
    10.12890/2018_000976
  5. "Quimioterapia neoadjuvante com duplo bloqueio HER2 em carcinoma mamário HER2-positivo". Cancer & Chemotherapy Rev. (2018):
    Published
Online resource
  1. MGMT promoter methylation: the impact in patients with gastroenteropancreatic neuroendocrine tumors treated with temozolomide-based therapy. 2019. https://doi.org/10.7490/f1000research.1116437.1.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/10/21 NGS nos tumores digestivos: para que doentes? 17º Congresso Nacional Cancro Digestivo
GICD (Portugal)
2018/03 Cancro de mama HER2-positivo ExpHERience Sharing Forum
2017/10 Chromophobe Renal Cell Carcinoma Meet the expert
(Portugal)
2016/11 Tumores do Pulmão - Casuística de 6 anos de um serviço. XXXII Congresso Nacional de Pneumologia
Sociedade Portuguesa de Pneumologia (Portugal)
2016/06 TEP como 1a Manifestação de Neoplasia Vesical TEV&CANCRO

Association member

Society Organization name Role
2017 - Current Ordem do Médicos - Secção Centro Gabinete de Qualidade em Saúde
2016 - Current Liga Portuguesa Contra o Cancro Formação na área da educação para saúde
2014 - Current Sociedade Portuguesa de Oncologia
2014 - Current European Society for Medical Oncology

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022/02/20 - 2022/02/20 Abordagem multidisciplinar na doença oncológica - Contributo da Oncologia médica para o tratamento (Outros) Ordem dos Médicos, Portugal
2021/11 - 2021/12 Curso Compreensivo de Tumores cutâneos - Formação Avançada (Outros) Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
Distinctions

Award

2018 Melhor Poster em Cancro da Cabeça e Pescoço Impacto do Índice de Massa Corporal na resposta dos doentes com carcinoma espinho-celular da cabeça e pescoço localmente avançado à QT/RT intensiva
SPO - Sociedade Portuguesa de Oncologia, Portugal
2016 Melhor Trabalho em Cancro da Mama - Mutação fundadora BRCA2 (c156_157insAlu) – Análise descritiva da população de doentes com cancro da mama.
SPO - Sociedade Portuguesa de Oncologia, Portugal

Other distinction

2018 ESO-Masterclass Grant
European School of Oncology, Italy
2017 ESMO Preceptorship travel grant
European Society for Medical Oncology, Switzerland