Personal identification

Full name

Paula Pousinha

Citation names

• Pousinha, Paula

Author identifiers

Ciência ID

6E1A-99F3-5650

ORCID iD

0000-0002-5992-9418

Knowledge fields

• Medical and Health Sciences - Basic Medicine - Neurosciences

	Degree	Classification
2023/09/21 Concluded	Neurosciences (Título de Habilitação de Coordenação Científica) Major in Neurophysiology Centre Inria d'Université Côte d'Azur, France
2012/07/04 Concluded	Ciências Biomédicas (Doutoramento) Major in Neurociências Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2017/09/01 - Current	Associate Professor (University Teacher)	Université Côte d'Azur, France

Contract

	Designation	Funders
2018 - Current	Mechanistic insight on Alzheimer’s disease using novel aging based models MB-7-2018 Principal investigator	Ongoing
2023/01/01 - 2026/12/31	Hippocampus – Nucleus Accumbens circuit in Aging: Unravelling APP Physiology ANR-22-CE37-0017-01 Principal investigator	Ongoing

Publications

Book	Pousinha, P.; Ribeiro, J.A.. Regulation of Synaptic Transmission by Adenosine at the Neuromuscular Junction. 2017.
Journal article	Jade Dunot; Sebastien Moreno; Carine Gandin; Paula A. Pousinha; Mascia Amici; Julien Dupuis; Margarita Anisimova; et al. "APP fragment controls both ionotropic and non-ionotropic signaling of NMDA receptors". Neuron (2024): http://dx.doi.org/10.1016/j.neuron.2024.05.027. 10.1016/j.neuron.2024.05.027 Jade Dunot; Aurore Ribera; Paula A. Pousinha; Hélène Marie. "Spatiotemporal insights of APP function". Current Opinion in Neurobiology 82 (2023): 102754-102754. http://dx.doi.org/10.1016/j.conb.2023.102754. 10.1016/j.conb.2023.102754 "Membrane electrical properties of mouse hippocampal CA1 pyramidal neurons during strong inputs". Biophysical Journal 121 4 (2022): 644-657. http://dx.doi.org/10.1016/j.bpj.2022.01.002. 10.1016/j.bpj.2022.01.002 "Cell-Type-Specific Adaptions in Striatal Medium-Sized Spiny Neurons and Their Roles in Behavioral Responses to Drugs of Abuse". Frontiers in Synaptic Neuroscience 13 (2021): http://dx.doi.org/10.3389/fnsyn.2021.799274. 10.3389/fnsyn.2021.799274 "A¿-a and A¿-ß peptides impair LTP ex vivo within the low nanomolar range and impact neuronal activity in vivo". Alzheimer's Research & Therapy 13 1 (2021): http://dx.doi.org/10.1186/s13195-021-00860-1. 10.1186/s13195-021-00860-1 "Missense mutation of Fmr1 results in impaired AMPAR-mediated plasticity and socio-cognitive deficits in mice". Nature Communications 12 1 (2021): http://dx.doi.org/10.1038/s41467-021-21820-1. 10.1038/s41467-021-21820-1 "Disrupting D1-NMDA or D2-NMDA receptor heteromerization prevents cocaine’s rewarding effects but preserves natural reward processing". Science Advances 7 43 (2021): http://dx.doi.org/10.1126/sciadv.abg5970. 10.1126/sciadv.abg5970 "IL-17 triggers the onset of cognitive and synaptic deficits in early stages of Alzheimer’s disease". Cell Reports 36 9 (2021): 109574-109574. http://dx.doi.org/10.1016/j.celrep.2021.109574. 10.1016/j.celrep.2021.109574 "Anti-Inflammatory Treatment with FTY720 Starting after Onset of Symptoms Reverses Synaptic Deficits in an AD Mouse Model". International Journal of Molecular Sciences 21 23 (2020): 8957-8957. http://dx.doi.org/10.3390/ijms21238957. 10.3390/ijms21238957 "Meningeal ¿d T cell–derived IL-17 controls synaptic plasticity and short-term memory". Science Immunology 4 40 (2019): http://dx.doi.org/10.1126/sciimmunol.aay5199. 10.1126/sciimmunol.aay5199 "The Amyloid Precursor Protein C-Terminal Domain Alters CA1 Neuron Firing, Modifying Hippocampus Oscillations and Impairing Spatial Memory Encoding". Cell Reports 29 2 (2019): 317-331.e5. http://dx.doi.org/10.1016/j.celrep.2019.08.103. 10.1016/j.celrep.2019.08.103 "Novel Players in the Aging Synapse: Impact on Cognition". Journal of Caffeine and Adenosine Research 9 3 (2019): 104-127. http://dx.doi.org/10.1089/caff.2019.0013. 10.1089/caff.2019.0013 "A two-hit story: Seizures and genetic mutation interaction sets phenotype severity in SCN1A epilepsies". Neurobiology of Disease 125 (2019): 31-44. http://dx.doi.org/10.1016/j.nbd.2019.01.006. 10.1016/j.nbd.2019.01.006 "Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors.". Molecular Psychiatry (2018): 10.1038/s41380-018-0110-9 Paula A Pousinha; Xavier Mouska; Elisabeth F Raymond; Carole Gwizdek; Gihen Dhib; Gwenola Poupon; Laure-Emmanuelle Zaragosi; et al. "Physiological and pathophysiological control of synaptic GluN2B-NMDA receptors by the C-terminal domain of amyloid precursor protein". eLife 6 (2017): https://doi.org/10.7554/eLife.25659. 10.7554/eLife.25659 Pousinha PA; Correia AM; Sebastião AM; Ribeiro JA. "The giant miniature endplate potentials frequency is increased in aged rats.". Neuroscience letters (2015): http://europepmc.org/abstract/med/25449868. 10.1016/j.neulet.2014.10.035 Nascimento F; Pousinha PA; Correia AM; Gomes R; Sebastião AM; Ribeiro JA. "Adenosine A2A receptors activation facilitates neuromuscular transmission in the pre-symptomatic phase of the SOD1(G93A) ALS mice, but not in the symptomatic phase.". PloS one (2014): http://europepmc.org/abstract/med/25093813. 10.1371/journal.pone.0104081 Rocha MC; Pousinha PA; Correia AM; Sebastião AM; Ribeiro JA. "Early changes of neuromuscular transmission in the SOD1(G93A) mice model of ALS start long before motor symptoms onset.". PloS one (2013): http://europepmc.org/abstract/med/24040091. 10.1371/journal.pone.0073846
Preprint	Joana Rajao-Saraiva; Mariana Temido-Ferreira; Joana E Coelho; Aurore Ribera; Sebastien Moreno; Michael Willem; Helene Marie; Luisa V. Lopes; Paula A Pousinha. "Age-dependent NMDA receptor function is regulated by the Amyloid Precursor Protein". 2022. https://doi.org/10.1101/2022.07.20.500736. 10.1101/2022.07.20.500736