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Evguenia Pavlovna Bekman completed a PhD in Biomedical Sciences in 1999 at Universidade do Porto, Instituto de Ciências Biomédicas Abel Salazar and Master in Biology/Animal Physiology/Embryology in 1989 at Moskovskij Gosudarstvennyj Universitet imeni M V Lomonosova, Biologiceskij fakul'tet. She is currently a senior researcher at the Institute for Bioengineering and Biosciences, Lisbon University, and assistant professor at Egas Moniz School of Health and Science, Monte de Caparica, where she teaches Molecular and Cellular Biology in Nutrition Science, Validation of Forensic Laboratory Methods and Animal Biology in Forensic Sciences. Her broad and multifaceted research interests encompass neuronal differentiation using embryonic stem cells (ES) and induced pluripotent stem cells (iPSCs), BAC recombineering, CRISPR/Cas9, and the establishment of engineered pluripotent stem cell lines, with pioneering report describing transcriptional signatures of in vitro derived neural progenitors recapitulating embryonic development (Abranches et al., 2009, >270 citations). Since 2016, she has focused her research on cerebellar organoid models using human iPSC lines (Silva et al., 2020, 2021, 2021a), being also a corresponding author of publication featuring 2D differentiation as a model for pre-natal exposure to cannabinoids (Miranda et al., 2020). Her ongoing research on a cerebellar organoid model for Angelman syndrome is being conducted in collaboration with Simão Teixeira da Rocha at Stem Cell Epigenetics Lab, iBB/IST. This project was funded by the European Angelman Syndrome Alliance in 2021 and has led to the establishment of several national and international collaborations. Evgenia’s publication record includes 30 research articles in peer-reviewed scientific journals and 3 book chapters, with over 1600 citations and h-index of 16. In addition to research, she is actively involved in community initiatives, raising awareness for rare diseases, and science communication for the general public. She is also collaborating with the Portuguese Association of Angelman Syndrome families, Angel.pt. Outside of professional life, she is passionate about music, natural medicine, personal development, women empowering, and education.
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Identification

Personal identification

Full name
Evguenia Pavlovna Bekman

Citation names

  • Bekman, Evguenia
  • Bekman, Evguenia P.

Author identifiers

Ciência ID
6D1D-1265-F8B6
ORCID iD
0000-0002-3963-1358
Google Scholar ID
https://scholar.google.com/citations?user=SQQa9qcAAAAJ
Researcher Id
O-9840-2017
Scopus Author Id
6602470751

Email addresses

  • evguenia.bekman@tecnico.ulisboa.pt (Professional)
  • ebekman@egasmoniz.edu.pt (Professional)

Addresses

  • Stem Cell Engineering and Regenerative Medicine Research Group, Institute for Bioengineering and Biosciences, IST - Taguspark, 2744-016, Porto Salvo, Oeiras, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Developmental Biology
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology

Languages

Language Speaking Reading Writing Listening Peer-review
Russian Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
1999
Concluded
 Ciências Biomédicas (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Família multigénica da ACC sintase em Lupinus albus: sua caracterização estrutural e análise da expressão (Multigenic family of ACC synthase in Lupinus albus: characterisation and expression analysis)" (THESIS/DISSERTATION)
 aprovado por unanimidade
1989
Concluded
 Biology (Master)
Major in Animal Physiology - Embryology
Moskovskij gosudarstvennyj universitet imeni M V Lomonosova Biologiceskij fakul'tet, Russia
"Obtaining transgenic mice containing gene of SV-40 large T-antigene under the control of HSV1 thymidine kinase promotor" (THESIS/DISSERTATION)
 Excellent
Affiliation

Science

Category
Host institution 		Employer
2017/08/01 - Current Invited Auxiliary Researcher (Research) Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
2014/04/01 - 2017/07/31 Postdoc (Research) Instituto de Medicina Molecular, Portugal
2004 - 2010 Postdoc (Research) Instituto de Medicina Molecular, Portugal
1999/07/01 - 2004/03/30 Postdoc (Research) Universidade de Lisboa Instituto de Histologia e Biologia do Desenvolvimento, Portugal
1989/09 - 1991/08 Research Trainee (Research) FBGUN Institut bioorganiceskoj himii im akademikov M M Semakina i U A Ovcinnikova Rossijskoj akademii nauk, Russia

Teaching in Higher Education

Category
Host institution 		Employer
2022/10/01 - Current Assistant Professor (University Teacher) Instituto Superior de Ciências da Saúde Egas Moniz, Portugal
2013 - 2016 Assistant Professor (University Teacher) Instituto Superior de Ciências da Saúde Egas Moniz, Portugal
2013 - 2014 Teacher Coordinator (Polytechnic Teacher) Escola Superior de Saúde Egas Moniz, Portugal

Others

Category
Host institution 		Employer
1995/01 - 1999/06 PhD student Instituto Gulbenkian de Ciência, Portugal
1991/09 - 1993/06 PhD student FBGUN Institut bioorganiceskoj himii im akademikov M M Semakina i U A Ovcinnikova Rossijskoj akademii nauk, Russia
Projects

Grant

Designation Funders
2022/04/01 - Current Stem cell toolkit for modelling cerebellar dysfunction in Angelman Syndrome
Research Grants on Angelman Syndrome
Principal investigator
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
 Angelman Syndrome Alliance
Ongoing
2020/03/01 - 2022/02/28 Exploring new therapeutic strategies for Angelman syndrome: A disease modelling approach based on 3D cerebellar organoids derived from patient iPSCs
PMJMCD 2019
Principal investigator
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação Maria Amélia de Mello
Concluded
2018 - 2021/06 CEREBEX - Generation of gene/edited cerebellar organoids for ataxia research
PTDC/BTM-SAL/29298/2017
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2016/05/01 - 2017/06/30 Making sense of antisense transcription
PTDC/BEX-BCM/5899/2014
Post-doc
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007/08/27 - 2010 NEURAL TALK - Scaffold-driven stem-cell regenerative therapy for the spinal cord injury. Biomimeting neurogenesis in the CNS.
PTDC/SAU-BEB/65328/2006
 Fundação para a Ciência e a Tecnologia
Concluded
2004 - 2006 Expansion and differentiation of neural stem cells in stirred bioreactors
POCTI/BIO/46695/2002
Post-doc
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2004 - 2006 Characterization of vertebrate prickle-like genes and their functional role during embryonic development
POCTI/48783/02
 Fundação para a Ciência e a Tecnologia
1999/07/01 - 2001 MOLECULAR MECHANISMS REGULATING ASYMMETRIC DIVISION OF NEURAL STEM CELLS
BPD/18857/98
Universidade de Lisboa Instituto de Histologia e Biologia do Desenvolvimento, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2021/01/01 - 2025/12/31 Institute for Health and Bioeconomy
LA/P/0140/2020
10.54499/LA/P/0140/2020
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

INESC Microsistemas e Nanotecnologias, Portugal

Universidade NOVA de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022/01/01 - 2022/08/31 CardioWheel
PTDC/EQU-EQU/29653/2017
Researcher
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2020/08/01 - 2021/05/31 Mini-Hearts
PTDC/EMD-TLM/29728/2017
Researcher
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2017/04/01 - 2020/07/31 The Discoveries Centre for Regenerative and Precision Medicine, H2020-WIDESPREAD-2016-2017 Teaming Phase2
info:eu-repo/grantAgreement/EC/H2020/739572/EU
Researcher
European Commission
2019/01/01 - 2019/12/31 Instituto de Medicina Molecular - IMM
UID/BIM/50005/2019
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2016/06/01 - 2019/11/30 O transcriptoma não codificante em envelhecimento e pluripotência
PTDC/BIM-MED/0032/2014
Universidade de Aveiro, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/04/18 - 2019/10/17 Vif na terapêutica do cancro da mama
PTDC/BIM-MEC/6631/2014
Instituto Universitário Egas Moniz Centro de Investigação Interdisciplinar Egas Moniz, Portugal

Egas Moniz - Cooperativa de Ensino Superior Crl, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2014/07/01 - 2017 RNPNET - RNP STRUCTURE, FUNCTION AND MECHANISM OF ACTION
PITN-GA-2011-289007
Post-doc Fellow
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/01/01 - 2010/08/31 Células estaminais: dialéctica, biologia e matemática
PTDC/SAU-OBD/100664/2008
Post-doc
Fundação para a Ciência e a Tecnologia
2007 - 2010 Stem cell based therapy for inner ear hair cell regeneration
PTDC/SAU-NEU/71310/2006
Post-doc Fellow
Fundação para a Ciência e a Tecnologia
Concluded
2004 - 2007 FunGenES- Functional Genomics in Engineered ES cells
LSH-2002-1.1.5-2
Post-doc Fellow
Instituto de Medicina Molecular, Portugal
 European Union
Concluded
2001 - 2004 Neural Stem Cells and stem cell-based therapies
QLG3-CT-2000-01224
Post-doc Fellow
Concluded
1994/10/01 - 1998/09/30 FAMÍLIA MULTIGÉNICA DE ACC SINTASE EM LUPINUS ALBUS E SUA EXPRESSÃO DURANTE O DESENVOLVIMENTO
PRAXIS XXI/BD/2808/94
Universidade do Porto Faculdade de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Maranga, Carina; Vieira, Adriana; Bekman, Evguenia P.; da Rocha, Simão T.. "Chapter 9: Induced pluripotent stem cells for modeling Angelman syndrome". In iPSCs for Modeling Central Nervous System Disorders. Elsevier, 2021.
    Published
  2. Bekman, Evguenia; Silva, Teresa P.; Cotovio, João P.; de Almeida, Rita Mendes. "Reproducing Human Brain Development In Vitro: Generating Cerebellar Neurons for Modelling Cerebellar Ataxias". In Concepts and Applications of Stem Cell Biology, edited by Gabriela Rodrigues; Bernard Roelen, 213-228. Springer International Publishing, 2020.
    Published • 10.1007/978-3-030-43939-2_11
  3. Maranga, Carina; Vieira, Adriana; Bekman, Evguenia; Rocha, Teixeira Simão. "iPSCs for modeling Angelman syndrome". In Induced Pluripotent Stem Cells ¿ Novel Concepts. Portugal: Elsevier, 2020.
    Submitted • 10.2174/9781681081168115010008
  4. Abranches, E.; Silva, M.; Pradier, L.; Schulz, H.; Hummel, O.; Henrique, D.; Bekman, E.. "Neural differentiation of embryonic stem cells in vitro: A road map to neurogenesis in the embryo". 76-104. 2011.
Conference abstract
  1. Rodrigues, Carlos A.V.; Nogueira, Diogo; Silva, Teresa P.; Fernandes, Tiago G.; Bekman, Evguenia; Hashimura, Y.; Jung, S.; et al. "Human Induced Pluripotent Stem Cell Culture in Vertical-Wheel Bioreactors". Paper presented in Virtual ESBES 2020, 2020.
    Published
  2. Silva, Teresa P.; Bekman, Evguenia P.; Fernandes, Tiago G.; Rodrigues, Carlos A.V.; Diogo, Maria Margarida; Cabral, Joaquim M. S.; Carmo-Fonseca, Maria. "Cerebellar differentiation and maturation from Human Induced Pluripotent Stem Cells". Paper presented in 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, Covilhã, 2017.
  3. Silva, Teresa P.; Bekman, Evguenia P.; Fernandes, Tiago G.; Rodrigues, Carlos A.V.; Diogo, Maria Margarida; Cabral, Joaquim M.S.; Carmo-Fonseca, Maria. "3D Cerebellar differentiation and Purkinje cell maturation from Human Induced Pluripotent Stem Cells". Paper presented in EMBO Symposium on Organoids: Modelling Organ Development and Disease in 3D Culture, Heidelberg, 2016.
    Published
Conference paper
  1. Bekman, Evguenia; Barata, Tiago; Miranda, Cláudia; Vaz, Sandra; Ferreira, Carla; Quintas, Alexandre. "Might synthetic cannabinoids influence neural differentiation?". Paper presented in Fourth International Congress of CiiEM: Health, Well-Being and Ageing in the 21st Century, Monte da Caparica, 2021.
    Published • 10.1080/07853890.2021.1893997
Conference poster
  1. Cazaux Mateus, Francisca; Camões dos Santos, João; Arez, Maria; Bekman, Evguenia; da Rocha, Simão T.. "A novel Stem Cell Model for Angelman Syndrome caused by Paternal Uniparental Disomy of Chromosome 15". Paper presented in IBB Meeting 2023, 2023.
  2. Cazaux Mateus, Francisca; Camões dos Santos, João; Arez, Maria; Bekman, Evguenia; da Rocha, Simão T.. "Stem Cell-Based Disease Modeling Of Angelman Syndrome Caused by Paternal Uniparental Disomy for Chromosome 15". Paper presented in SPCE-ETRS Joint Annual Meeting 2023, 2023.
  3. Covas, Rita; Ferreira, Carla; de Lemos, Luisa; Tenreiro, Sandra; Quintas, Alexandre; Bekman, Evguenia P.. Corresponding author: Covas, Rita. "Development of an organoid-based model to study prenatal exposure to cannabinoids". Paper presented in 14.0 iMed Conference, 2022.
  4. Covas, Rita; Ferreira, Carla; de Lemos, L; Tenreiro, Sandra; Quintas, Alexandre; Bekman, Evguenia P.. Corresponding author: Bekman, Evguenia P.. "Evaluating THC and CBD effects on an organoid-based model of prenatal exposure". Paper presented in VIII International Congress of Forensic Sciences and Criminal Behaviour, 2022.
  5. da Rocha, Simão T.; Maranga, Carina; Ana Cláudia Raposo; Vieira, Adriana; Arez, Maria; Gomes, Alípio; Dias, Laura; et al. "A personalized stem cell toolkit for modeling human disorders". Paper presented in 12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2022.
  6. Alípio Gomes; Vieira, Adriana; Maranga, Carina; Casanova, Miguel; Laura Steenpass; Cabral, Joaquim; Fernandes, Tiago G.; da Rocha, Simão Teixeira; Bekman, Evguenia P.. "Correction of disease-causing mutation in Angelman syndrome patient derived iPSC line by CRISPR/Cas9". Paper presented in 12th International Meeting of the Portuguese Society for Stem Cells and Cell therapies, 2022.
  7. Maranga, Carina; Silva, Teresa P.; Vaz, Sandra H.; Cabral, Joaquim; da Rocha, Simão Teixeira; Fernandes, Tiago G.; Bekman, Evguenia P.. "Recapitulating disease features in cerebellar organoids model of Angelman syndrome". Paper presented in 12th International Meeting of the Portuguese Society for Stem Cells and Cell therapies, 2022.
  8. Maranga, Carina; Silva, Teresa P.; Vaz, Sandra H.; Cabral, Joaquim M.S; da Rocha, Simão T.; Fernandes, Tiago G.; Bekman, Evguenia. "Modeling Angelman Syndrome with human induced pluripotent stem cell-derived cerebellar organoids". Paper presented in Vienna Biocenter PhD Symposium 2021 'Building Bridges', 2021.
  9. Maranga, Carina; Vieira, Adriana A; Fernandes, Tiago G.; Cabral, Joaquim M. S.; da Rocha, Simão T.; Bekman, Evguenia P.. "Brain-in-a-dish approach for studying Angelman Syndrome". Paper presented in Neuroepigenetics: From Cells to Behaviour and Disease Virtual EMBO Workshop, 2020.
  10. Ana Rita Gomes; Fernandes, Tiago G.; Vaz, Sandra H.; Silva, Teresa P.; Bekman, Evguenia; Xapeli, Sara; Sebastião, AM; Joaquim M.S. Cabral; Diogo, Maria Margarida. "Modelling Rett syndrome with human patient-specific forebrain organoids". Paper presented in EMBO Symposium on Organoids: Modelling Organ Development and Disease in 3D Culture, 2020.
  11. Maranga, Carina; Silva, Teresa P.; Fernandes, Tiago G.; da Rocha, Simão T.; Bekman, Evguenia P.; Cabral, Joaquim M. S.. "hiPSC-derived cerebellar organoids to model Angelman Syndrome". Paper presented in Organoids: Modelling Organ Development and Disease in 3D culture, Virtual EMBO Conference, 2020.
  12. Vieira, Adriana A.; Maranga, Carina; Gomes, Ana; Bekman, Evguenia; da Rocha, Simão T.. "Modeling of Angelman Syndrome using the Neural Commitment of Patient-Specific iPSCs". Paper presented in Innovate Competition ¿ AstraZeneca Foundation, 2020.
  13. Silva, Teresa P.; Fernandes, Tiago G.; Bekman, Evguenia P.; Vaz, Sandra H.; Rodrigues, Carlos A.V.; Hashimura, Yas; Jung, S; et al. "Large scale production of cerebellar organoids from human pluripotent stem cells using the novel Vertical-Wheel single-use bioreactors". Paper presented in 7th International Conference on Stem Cell Engineering, Barcelona, Spain, 2019.
  14. Maranga, Carina; Silva, Teresa P.; Vaz, Sandra H.; Teixeira da Rocha, Simão; Fernandes, Tiago G.; Bekman, Evguenia P.; Cabral, Joaquim M. S.. "Cerebellar organoids derived from human pluripotent stem cells to model Angelman Syndrome". Paper presented in International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, Lisbon, Portugal, 2019.
  15. Silva, Teresa P.; Fernandes, Tiago G.; Bekman, Evguenia P.; Vaz, Sandra H.; Rodrigues, Carlos A.V.; Hashimura, Yas; Jung, S; et al. "Scalable generation of cerebellar neurons from pluripotent stem cells". Paper presented in Advancing Manufacture of Cell and Gene Therapies VI, California, USA, 2019.
  16. Silva, Teresa P.; Fernandes, Tiago G.; Bekman, Evguenia P.; Vaz, Sandra H.; Rodrigues, Carlos A.V.; Hashimura, Yas; Jung, S; et al. "Scalable generation of mid-hindbrain organoids from human pluripotent stem cells". Paper presented in EMBO Symposium on Organoids: Modelling Organ Development and Disease in 3D Culture, Heidelberg, Germany, 2018.
  17. Silva, Teresa P.; Fernandes, Tiago G.; Bekman, Evguenia P.; Rodrigues, Carlos A.V.; Diogo, Maria Margarida; Carmo-Fonseca, Maria; Cabral, Joaquim M.S.. "Cerebellar differentiation and Purkinje cell maturation from Human Induced Pluripotent Stem Cells". Paper presented in International Conference on Stem Cell Engineering, 2016.
Journal article
  1. Camões dos Santos, João; Appleton, Carolina; Cazaux Mateus, Francisca; Covas, Rita; Bekman, Evguenia P.; da Rocha, Simão T.. Corresponding author: da Rocha, Simão T.. "Stem cell models of Angelman syndrome". Frontiers in Cell and Developmental Biology 11 (2023):
    Published
  2. Carina Maranga; Carolina Pereira; Ana Cláudia Raposo; Adriana Vieira; Sofia Duarte; Bekman, Evguenia P.; Inês Milagre; Simão Teixeira da Rocha. Corresponding author: Simão Teixeira da Rocha. "Generation and characterization of induced pluripotent stem cell line (IBBISTi004-A) from an Angelman syndrome patient carrying a class II deletion of the maternal chromosome 15q11.2-q13". Stem Cell Research 61 (2022): 102757-102757. http://dx.doi.org/10.1016/j.scr.2022.102757.
    10.1016/j.scr.2022.102757
  3. Teresa P. Silva; Rui Sousa-Luís; Tiago G. Fernandes; Evguenia P. Bekman; Carlos A. V. Rodrigues; Sandra H. Vaz; Leonilde M. Moreira; et al. "Transcriptome profiling of human pluripotent stem cell-derived cerebellar organoids reveals faster commitment under dynamic conditions". Biotechnology and Bioengineering (2021): https://doi.org/10.1002/bit.27797.
    10.1002/bit.27797
  4. Gomes, Ana Rita; Fernandes, Tiago G.; Vaz, Sandra H.; Silva, Teresa P.; Bekman, Evguenia P.; Xapelli, Sara; Duarte, Sofia; et al. "Modeling Rett Syndrome With Human Patient-Specific Forebrain Organoids". Frontiers in Cell and Developmental Biology 8 (2020): http://dx.doi.org/10.3389/fcell.2020.610427.
    Open access • Published • 10.3389/fcell.2020.610427
  5. Miranda, Cláudia; Barata, Tiago; Vaz, Sandra H.; Ferreira, Carla; Quintas, Alexandre; Bekman, Evguenia. "hiPSC-Based Model of Prenatal Exposure to Cannabinoids: Effect on Neuronal Differentiation". Frontiers in Molecular Neuroscience (2020): http://dx.doi.org/10.3389/fnmol.2020.00119.
    10.3389/fnmol.2020.00119
  6. Silva, Teresa P.; Fernandes, Tiago G.; Nogueira, Diogo E. S.; Rodrigues, Carlos A. V.; Bekman, Evguenia P.; Hashimura, Yas; Jung, Sunghoon; et al. "Scalable Generation of Mature Cerebellar Organoids from Human Pluripotent Stem Cells and Characterization by Immunostaining". Journal of Visualized Experiments 160 (2020): http://dx.doi.org/10.3791/61143.
    Published • 10.3791/61143
  7. Maranga, Carina; Fernandes, Tiago G.; Bekman, Evguenia; Teixeira da Rocha, Simão. "Angelman Syndrome: a journey through the brain". The FEBS Journal (2020): http://dx.doi.org/10.1111/febs.15258.
    10.1111/febs.15258
  8. Silva, Teresa P.; Bekman, Evguenia P.; Fernandes, Tiago G.; Vaz, Sandra H.; Rodrigues, Carlos A. V.; Diogo, Maria Margarida; Cabral, Joaquim M. S.; Carmo-Fonseca, Maria. "Maturation of Human Pluripotent Stem Cell-Derived Cerebellar Neurons in the Absence of Co-culture". Frontiers in Bioengineering and Biotechnology 8 (2020): http://dx.doi.org/10.3389/fbioe.2020.00070.
    10.3389/fbioe.2020.00070
  9. Bandarra, Susana; Mascarenhas, Paulo; Luís, Ana R.; Catrau, Mafalda; Bekman, Evguenia; Ribeiro, Ana C.; Félix, Sérgio; Caldeira, Jorge; Barahona, Isabel. "In vitro and in silico evaluations of resin-based dental restorative material toxicity". Clinical Oral Investigations (2019): http://dx.doi.org/10.1007/s00784-019-03131-4.
    10.1007/s00784-019-03131-4
  10. Silva, Teresa P.; Cotovio, João P.; Bekman, Evguenia; Carmo-Fonseca, Maria; Cabral, Joaquim M. S.; Fernandes, Tiago G.. "Design Principles for Pluripotent Stem Cell-Derived Organoid Engineering". Stem Cells International 2019 (2019): 1-17. http://dx.doi.org/10.1155/2019/4508470.
    10.1155/2019/4508470
  11. Bandarra, Susana; Clara Ribeiro, Ana; Mascarenhas, Paulo; Bekman, Evguenia; Barahona, Isabel. "Production of breast cancer cell lines expressing viral gene VIF". Annals of Medicine 51 sup1 (2019): 39-39. http://dx.doi.org/10.1080/07853890.2018.1561805.
    10.1080/07853890.2018.1561805
  12. Salema-Oom, Madalena; Bekman, Evguenia; Bandarra, Susana; Mascarenhas, Paulo; Clara Ribeiro, Ana; Oliveira, Pedro; Antunes, Eduardo; Barahona, Isabel. "Why fibrosis after exposure to low frequency noise?". Annals of Medicine 51 sup1 (2019): 41-41. http://dx.doi.org/10.1080/07853890.2018.1561854.
    10.1080/07853890.2018.1561854
  13. Arruda, Diogo; Bandarra, Susana; Carvalho, Joana; Clara Ribeiro, Ana; Mascarenhas, Paulo; Bekman, Evguenia; Félix, Sérgio; Barahona, Isabel. "Effect of polymerization methods in the cytotoxicity of two resins used in removable prosthodontics ¿ an in vitro study". Annals of Medicine 51 sup1 (2019): 146-146. http://dx.doi.org/10.1080/07853890.2018.1561990.
    10.1080/07853890.2018.1561990
  14. Maranga, Carina; Da Silva, Teresa; Vaz, Sandra; Da Rocha, Simão; Fernandes, Tiago; Bekman, Evguenia; Cabral, Joaquim. "Disease modeling of Angelman syndrome using hiPSC-derived cerebellar organoids". Frontiers in Cellular Neuroscience 13 (2019): http://dx.doi.org/10.3389/conf.fncel.2019.01.00041.
    10.3389/conf.fncel.2019.01.00041
  15. Barata, Tiago; Miranda, Claudia; Vaz, Sandra; Ferreira, Carla; Quintas, Alexandre; Bekman, Evguenia. "Cannabinoids affect differentiation of human iPSC-derived neurons". Frontiers in Cellular Neuroscience 13 (2019): http://dx.doi.org/10.3389/conf.fncel.2019.01.00040.
    10.3389/conf.fncel.2019.01.00040
  16. Pereira, Pedro D.; Caetano, Ana Serra; Cabrita, Marisa; Bekman, Evguenia; Braga, José; Rino, José; Santus, Renè; et al. "Quantification of cell cycle kinetics by EdU (5-ethynyl-2'-deoxyuridine)-coupled-fluorescence-intensity analysis". (2017): http://hdl.handle.net/10451/28768.
    10.18632/oncotarget.17121
  17. Abranches, E.; Bekman, E.; Henrique, D.. "Erratum: Generation and characterization of a novel nouse embryonic stem cell line with a dynamic reporter of nanog expression (PLOS ONE (2013) 8, 3 (e59928) DOI: 10.1371/journal.pone.0059928)". PLoS ONE 9 6 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84903289164&partnerID=MN8TOARS.
    10.1371/journal.pone.0101028
  18. Abranches, E.; Bekman, E.; Henrique, D.. "Generation and Characterization of a Novel Mouse Embryonic Stem Cell Line with a Dynamic Reporter of Nanog Expression". PLoS ONE 8 3 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84875117561&partnerID=MN8TOARS.
    10.1371/journal.pone.0059928
  19. Bekman, E.P.; Costa, A.; Cristóvão, A.M.; Henrique, D.. "Stem cell therapy for inner ear hair cell regeneration". International Journal of Developmental Neuroscience 28 8 (2010): 667-668. http://dx.doi.org/10.1016/j.ijdevneu.2010.07.077.
    10.1016/j.ijdevneu.2010.07.077
  20. Costa, A.; Bekman, E.; Henrique, D.. "From embryonic stem cells to sensory hair cells: A cell reprogramming approach". International Journal of Developmental Neuroscience 28 8 (2010): 662-662. http://dx.doi.org/10.1016/j.ijdevneu.2010.07.063.
    10.1016/j.ijdevneu.2010.07.063
  21. Abranches, E.; Silva, M.; Pradier, L.; Schulz, H.; Hummel, O.; Henrique, D.; Bekman, E.. "Neural differentiation of embryonic stem cells in vitro: A road map to neurogenesis in the embryo". PLoS ONE 4 7 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-67651243800&partnerID=MN8TOARS.
    10.1371/journal.pone.0006286
  22. Fernandes, A.; Falcão, A.S.; Abranches, E.; Bekman, E.; Henrique, D.; Lanier, L.M.; Brites, D.; et al. "Bilirubin as a determinant for altered neurogenesis, neuritogenesis, and synaptogenesis". Developmental Neurobiology 69 9 (2009): 568-582. http://www.scopus.com/inward/record.url?eid=2-s2.0-67749127695&partnerID=MN8TOARS.
    10.1002/dneu.20727
  23. Abranches, E.; Bekman, E.; Henrique, D.; Cabral, J.M.S.. "Expansion of mouse embryonic stem cells on microcarriers". Biotechnology and Bioengineering 96 6 (2007): 1211-1221. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247101508&partnerID=MN8TOARS.
    10.1002/bit.21191
  24. Duarte, A.; Hirashima, M.; Benedito, R.; Trindade, A.; Diniz, P.; Bekman, E.; Costa, L.; Henrique, D.; Rossant, J.. "Dosage-sensitive requirement for mouse Dll4 in artery development". Genes and Development 18 20 (2004): 2474-2478. http://www.scopus.com/inward/record.url?eid=2-s2.0-5444261424&partnerID=MN8TOARS.
    10.1101/gad.1239004
  25. Albranches, E.; Bekman, E.; Henrique, D.; Cabral, J.M.S.. "Expansion and neural differentiation of embryonic stem cells in adherent and suspension cultures". Biotechnology Letters 25 9 (2003): 725-730. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037680702&partnerID=MN8TOARS.
    10.1023/A:1023462832608
  26. Abranches, E.; Bekman, E.; Henrique, D.; Cabral, J.M.S.. "Erratum: Expansion and neural differentiation of embryonic stem cells in adherent and suspension cultures (Biotechnology letters (2003) 25 (725-730))". Biotechnology Letters 25 12 (2003): http://www.scopus.com/inward/record.url?eid=2-s2.0-0037742397&partnerID=MN8TOARS.
  27. Bekman, E.; Henrique, D.. "Embryonic expression of three mouse genes with homology to the Drosophila melanogaster prickle gene". Mechanisms of Development 119 SUPPL. 1 (2002): 73-77. http://www.scopus.com/inward/record.url?eid=2-s2.0-10644282055&partnerID=MN8TOARS.
    10.1016/S0925-4773(03)00095-9
  28. Scarafoni, A.; Di Cataldo, A.; Vassilevskaia, T.D.; Bekman, E.P.; Rodrigues-Pousada, C.; Ceciliani, F.; Duranti, M.. "Cloning, sequencing and expression in the seeds and radicles of two Lupinus albus conglutin ¿ genes". Biochimica et Biophysica Acta - Gene Structure and Expression 1519 1-2 (2001): 147-151. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035962825&partnerID=MN8TOARS.
    10.1016/S0167-4781(01)00225-1
  29. Bekman, E.P.; Saibo, N.J.M.; Di Cataldo, A.; Regalado, A.P.; Ricardo, C.P.; Rodrigues-Pousada, C.. "Differential expression of four genes encoding 1-aminocyclopropane-1-carboxylate synthase in Lupinus albus during germination, and in response to indole-3-acetic acid and wounding". Planta 211 5 (2000): 663-672. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033788073&partnerID=MN8TOARS.
  30. Bekman, E.P.; Saibo, N.J.M.; Ricardo, C.P.; Rodrigues-Pousada, C.. "Characterization of three members of the ACC synthase gene family in Lupinus albus". FASEB Journal 11 9 (1997): http://www.scopus.com/inward/record.url?eid=2-s2.0-33750128210&partnerID=MN8TOARS.
  31. Vassilevskaia, T.D.; Bekman, E.; Jackson, P.; Ricardo, C.P.; Rodrigues-Pousada, C.; Vassilevskaia, Tatiana D.; Bekman, Evguenia; et al. "Developmental expression and regulation by light of two closely related ß-tubulin genes in Lupinus albus". Plant Molecular Biology 32 6 (1996): 1185-1189. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030480556&partnerID=MN8TOARS.
    10.1007/BF00041404
  32. Luk'ianov, K.A.; Tarabykin, V.S.; Potapov, V.K.; Bekman, E.P.; Luk'ianov, S.A.. "The cloning of fragments of homeobox genes expressed during planarian regeneration | Klonirovanie fragmentov gomeobokssoderzhashchikh genov, ékspressiruiushchikhsia v khode regeneratsii planarii.". Ontogenez 25 6 (1994): 28-32. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028537021&partnerID=MN8TOARS.
  33. Akopyanz, N.S.; Broude, N.E.; Bekman, E.P.; Marzen, E.O.; Sverdlov, E.D.. "Tissue-specific expression of Na,K-ATPase ß-subunit Does ß2 expression correlate with tumorigenesis?". FEBS Letters 289 1 (1991): 8-10. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025812383&partnerID=MN8TOARS.
Newsletter article
  1. Maranga, Carina; Vieira, Adriana A.; Bekman, Evguenia; da Rocha, Simão T.. "Ensaios clínicos em Angelman... e em Portugal?", Newsletter trimestral da Angel, 2020, https://mcusercontent.com/c1201a436f7baec28794d7be1/files/85b64f55-3c95-4997-a30f-ceca8eeac0b0/Newsletter_14.pdf.

Other

Other output
  1. Neural Differentiation of Embryonic Stem Cells In Vitro. Current Research in Embryology. 2011. Abranches, Elsa; Silva, Margarida; Pradier, Laurent; Schulz, Herbert; Hummel, Oliver; Henrique, Domingos; Bekman, Evguenia. http://dx.doi.org/10.1201/b12877-6.
    10.1201/b12877-6
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022/09/01 - 2024/03/21 Stem cell-based modelling of cerebellar dysfunction in Angelman Syndrome
Supervisor
 Mestrado em Biologia Evolutiva e do Desenvolvimento (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2020/03/01 - 2023/11/30 Modelling Angelman Syndrome in CRISPR-edited isogenic iPSCs
Supervisor
 Master of Science Degree in Biological Engineering (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/09/06 - 2022/12/06 EVALUATING THE EFFECTS OF SYNTHETIC CANNABINOIDS - AN ORGANOID-BASED MODEL FOR PRE-NATAL EXPOSURE
Co-supervisor
 MESTRADO EM TECNOLOGIAS LABORATORIAIS EM CIÊNCIAS FORENSES (Master)
Instituto Superior de Ciências da Saúde Egas Moniz, Portugal
2022/02/28 - 2022/11/21 Using CRISPR-Cas9 to generate an Isogenic Cell Line from Patient-Derived Human Induced Pluripotent Stem Cells to model Niemann-Pick Type C1 Cerebellar Ataxia
Supervisor
 MESTRADO EM ENGENHARIA BIOLÓGICA (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2019/09/01 - 2021/02/24 In Vitro Modeling of Angelman Syndrome using the Neural Commitment of Patient-Specific iPSCs
Supervisor
 Biologia Molecular e Genética (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2018 - 2021 Scalable production of mature neuronal subtypes from cerebellar organoids in dynamic 3D conditions to model human disease
Co-supervisor
 Bioengineering Cell Therapies and Regenerative Medicine (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2017 - 2018/11 Generating isogenic NPC1 hiPSC lines for disease modeling using the CRISPR/Cas9 system
Supervisor
 Biomedical Engineering (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015 - 2018 Novel bioengineering strategies for modeling cerebellar ataxias
Co-supervisor
 Bioengineering – Cell Therapies and Regenerative Medicine (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 - 2017/11 Genome editing of Mesenchymal Stem/Stromal Cells (MSCs) by CRISPR/Cas9 technology for azurin-based anticancer therapies
Co-supervisor
 Biomedical Engineering (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2017 - 2017 O tratamento das neoplasias malignas recorrendo às células progenitoras hematopoiéticas
Supervisor
 Ciências Farmacêuticas (Master)
Instituto Superior de Ciências da Saúde Egas Moniz, Portugal
2017 - 2017 A aplicação de células estaminais na medicina regenerativa
Supervisor
 Ciências Farmacêuticas (Master)
Instituto Superior de Ciências da Saúde Egas Moniz, Portugal
2015 - 2016/10 Using CRISPR-Cas technology to generate inducible KO mouse ES cell lines for Ago1 and Ago3
Supervisor
 Biological Engineering (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 - 2016 Neurogénese in vitro e aplicações biomédicas
Supervisor
 Ciências Farmacêuticas (Master)
Instituto Superior de Ciências da Saúde Egas Moniz, Portugal
2015 - 2015 Técnicas de edição de genoma como abordagem promissora na terapia génica
Supervisor
 Ciências Farmacêuticas (Master)
Instituto Superior de Ciências da Saúde Egas Moniz, Portugal
2015 - 2015 Novas abordagens na terapia genética em doenças mitocondriais
Supervisor
 Ciências Farmacêuticas (Master)
Instituto Superior de Ciências da Saúde Egas Moniz, Portugal
2015 - 2015 As células IPS e o seu uso na construção de modelos celulares de doenças humanas
Supervisor
 Ciências Farmacêuticas (Master)
Instituto Superior de Ciências da Saúde Egas Moniz, Portugal
2014 - 2014 Engenharia dos tecidos e órgãos: sucessos e desafios
Supervisor
 Ciências Farmacêuticas (Master)
Instituto Superior de Ciências da Saúde Egas Moniz, Portugal
2014 - 2014 Células estromais mesenquimais (MSC) como agentes terapêuticos
Supervisor
 Ciências Farmacêuticas (Master)
Instituto Superior de Ciências da Saúde Egas Moniz, Portugal
2013 - 2013 Neurogénese no cérebro adulto
Supervisor
 Ciências Farmacêuticas (Master)
Instituto Superior de Ciências da Saúde Egas Moniz, Portugal

Association member

Society Organization name Role
2007 - Current Sociedade Portuguesa de Neurociências Member
2006 - Current Sociedade Portuguesa de Células Estaminais e Terapia Celular Founding member
2006 - Current Sociedade Portuguesa de Biologia do Desenvolvimento Founding member

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2012 - 2018 Cellular and molecular biology Medicina Dentária (Mestrado integrado) Instituto Superior de Ciências da Saúde Egas Moniz, Portugal
2014 - 2017 Animal and Plant Biology Ciências Forenses e Criminais (Licenciatura) Instituto Superior de Ciências da Saúde Egas Moniz, Portugal
2013 - 2015 Stem cells and cellular therapies Ciências Farmacêuticas (Mestrado integrado) Instituto Superior de Ciências da Saúde Egas Moniz, Portugal
2010 - 2012 Cellular and molecular biology Ciências da Nutrição (Licenciatura) Instituto Superior de Ciências da Saúde Egas Moniz, Portugal
Distinctions

Award

2019 Bolsa Pedro Maria José Mello Costa Duarte
Fundação Amélia Da Silva De Mello, Portugal