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Nícia Rosário-Ferreira, PURR.AI's Chief Scientific Officer, boasts a distinguished academic background with top honors from Portugal's leading universities. Transitioning from experimental to computational research during her PhD, she delved into protein interactions and GPCRs. Her involvement in various research projects and entrepreneurship programs, coupled with her role at PURR.AI, showcases her expertise in employing AI and computational techniques for groundbreaking discoveries in bioinformatics.
Identification

Personal identification

Full name
Nicia Filipa Rosário Ferreira

Citation names

  • Rosário-Ferreira, Nicia

Author identifiers

Ciência ID
6D10-1944-94E3
ORCID iD
0000-0002-7225-9287

Email addresses

  • nfferreira@cnc.uc.pt (Professional)
  • nirferreira@gmail.com (Personal)

Websites

Knowledge fields

  • Exact Sciences - Computer and Information Sciences - Bioinformatics
  • Medical and Health Sciences - Medical Biotechnology
  • Natural sciences - Biological Sciences - Biochemistry
  • Medical and Health Sciences - Basic Medicine - Toxicology
  • Medical and Health Sciences - Other Medical Sciences - Forensic Science

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese (Mother tongue)
Education
Degree Classification
2017/06/01 - 2023/04/16
Concluded
 Biological Chemistry (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"EXPLORING PROTEIN-PROTEIN AND PROTEIN-RNA INTERACTIONS IN INFLUENZA VIRUS’ NONSTRUCTURAL PROTEIN 1 (NS1)" (THESIS/DISSERTATION)
2014/09 - 2016/11
Concluded
 Analytical, Clinical and Forensic Toxicology (Mestrado)
Major in Sem especialização
Universidade do Porto Faculdade de Farmácia, Portugal
"Hair Metabolomics Applied to Gender Differentiation" (THESIS/DISSERTATION)
2011/09 - 2014/07
Concluded
 Forensic and Criminal Sciences (Licenciatura)
Instituto Universitário de Ciências da Saúde, Portugal
"Differential Analysis by Sex in Hair: Past Approaches and Future Perspectives" (THESIS/DISSERTATION)
 14
Affiliation

Science

Category
Host institution 		Employer
2023/06/15 - Current Contracted Researcher (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/08/05 - 2022/11/04 Contracted Researcher (Research) Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal

Positions / Appointments

Category
Host institution 		Employer
2023/08/17 - Current Co-Founder PURR.AI, Portugal
Projects

Contract

Designation Funders
2021/02/01 - 2024/01/31 Descoberta do Interactoma vírus-hospedeiro: uma abordagem guiada por AI e dados multi-ómicos <br>
DSAIPA/DS/0118/2020
Team Member
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

CNC.IBILI, Portugal

Instituto de Engenharia de Sistemas e Computadores Investigação e Desenvolvimento em Lisboa, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/09/03 - 2022/03/04 Proteínas Membranares - desenvolvimento de novas técnicas de modelação computacional e sua aplicação ao estudo dos recetores acoplados a proteína G
PTDC/QUI-OUT/32243/2017
Team Member
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018/06/15 - 2021/12/14 Aplicação de Deep Learning ao processo de investigação de novas drogas anticancerígenas
PTDC/CCI-BIO/31356/2017
Team Member
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Instituto de Engenharia de Sistemas e Computadores Tecnologia e Ciência, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018/08/01 - 2021/07/31 Novos antivirais contra Influenza: validação do alvo NS1 e descoberta de compostos líder
PTDC/QUI-OUT/32572/2017
Team Member
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2022/12/01 - 2023/11/30 Molecular-level understanding of receptor binding of engineered high-density lipoprotein particles that chaperone bioactive lipid mediator sphingosine 1-phosphate (S1P)
MCB220005P
Researcher
Ongoing
Outputs

Publications

Book chapter
  1. Piochi, L.F.; Gaspar, A.T.; Rosário-Ferreira, N.; Preto, A.J.; Moreira, I.S.. "From single-omics to interactomics: How can ligand-induced perturbations modulate single-cell phenotypes?". In Advances in Protein Chemistry and Structural Biology, 45-83. Elsevier, 2022.
    10.1016/bs.apcsb.2022.05.006
  2. Rosário-Ferreira, Nícia; Marques-Pereira, Catarina; Gouveia, Raquel P.; Mourão, Joana; Moreira, Irina S.. "Guardians of the Cell: State-of-the-Art of Membrane Proteins from a Computational Point-of-View". In Computational Design of Membrane Proteins, 3-28. Springer US, 2021.
    10.1007/978-1-0716-1468-6_1
  3. Preto, A.J.; Marques-Pereira, C; Baptista, Salete J.; Bueschbell, B.; Barreto, Carlos A.V.; Gaspar, A.T.; Pinheiro, I.; et al. "Targeting GPCRs Via Multi-Platforms Arrays and AI". In Reference Module in Biomedical Sciences. Elsevier, 2021.
    10.1016/b978-0-12-820472-6.00048-7
Conference poster
  1. Rosário-Ferreira, Nicia; Melo, Rita; Moreira, Irina S; Rui M M Brito. "NS1 dimer behavior through a Molecular Dynamics lens". Paper presented in Coimbra Chemistry Centre Day, 2021.
  2. Rosário-Ferreira, Nicia; Guimarães, Victor; Costa, Vítor; Moreira, Irina S. "Boosting network biology using a cutting-edge text-mining approach". Paper presented in Network Biology, 2021.
  3. Rosário-Ferreira, Nicia; Melo, Rita; Moreira, Irina S; Rui M M Brito. "A molecular Dynamics study of non-structural protein1 (NS1)". Paper presented in Encontro de Jovens Investigadores de Biologia Computacional Estrutural, 2019.
  4. Rosário-Ferreira, Nicia; Melo, Rita; Moreira, Irina S; Rui M M Brito. "A molecular Dynamics study of non-structural protein1 (NS1)". Paper presented in Advances in Computational Biology Conference – Fostering Collaboration Among Women Scientists, 2019.
  5. Rosário-Ferreira, Nicia; Melo, Rita; Moreira, Irina S; Rui M M Brito. "Understanding the role of the non-structural protein I in the pathogenicity of influenza virus using a computational approach". Paper presented in Structural Bioinformatics Course, 2019.
  6. Rosário-Ferreira, Nicia; Melo, Rita; Moreira, Irina S; Rui M M Brito. "An integrative approach to understand protein plasticity – The case of non-structural protein 1 from the influenza virus". Paper presented in PTNMR Satellite Meeting, 2019.
  7. Rosário-Ferreira, Nicia; Melo, Rita; Moreira, Irina S; Rui M M Brito. "A Molecular Dynamics Insight to Non-Structural Protein 1 (NS1) – A Hub Protein Essential for Influenza Infection.". Paper presented in 4th Instruct Biennial Structural Biology Conference, 2019.
  8. Rosário-Ferreira, Nicia; Melo, Rita; Moreira, Irina S; Rui M M Brito. "Outline of a Molecular Dynamics Approach to Non- Structural Protein 1 (NS1) – A Hub Protein essential for Influenza Infection". Paper presented in Encontro de Jovens Investigadores de Biologia Computacional Estrutural, 2018.
Journal article
  1. Catarina Marques-Pereira; Manuel N. Pires; Raquel P. Gouveia; Nádia N. Pereira; Ana B. Caniceiro; Nícia Rosário-Ferreira; Irina S. Moreira. "SARS-CoV-2 Membrane Protein: From Genomic Data to Structural New Insights". International Journal of Molecular Sciences 23 6 (2022): 2986-2986. https://doi.org/10.3390/ijms23062986.
    10.3390/ijms23062986
  2. Nícia Rosário-Ferreira; Alexandre M. J. J. Bonvin; Irina S. Moreira. "Using machine-learning-driven approaches to boost hot-spot's knowledge". WIREs Computational Molecular Science (2022): https://doi.org/10.1002/wcms.1602.
    10.1002/wcms.1602
  3. Bueschbell, Beatriz; Caniceiro, Ana Beatriz; Suzano, Pedro M.S.; Machuqueiro, Miguel; Rosário-Ferreira, Nícia; Moreira, Irina S.. "Network biology and artificial intelligence drive the understanding of the multidrug resistance phenotype in cancer". Drug Resistance Updates 60 (2022): 100811. http://dx.doi.org/10.1016/j.drup.2022.100811.
    10.1016/j.drup.2022.100811
  4. Nícia Rosário-Ferreira; Salete J. Baptista; Carlos A. V. Barreto; Filipe E. P. Rodrigues; Tomás F. D. Silva; Sara G. F. Ferreira; João N. M. Vitorino; et al. "In Silico End-to-End Protein–Ligand Interaction Characterization Pipeline: The Case of SARS-CoV-2". ACS Synthetic Biology (2021): https://doi.org/10.1021/acssynbio.1c00368.
    10.1021/acssynbio.1c00368
  5. Rosário-Ferreira, Nícia; Guimarães, Victor; Costa, Vítor S.; Moreira, Irina S.. "SicknessMiner: a deep-learning-driven text-mining tool to abridge disease-disease associations". BMC Bioinformatics 22 1 (2021): http://dx.doi.org/10.1186/s12859-021-04397-w.
    10.1186/s12859-021-04397-w
  6. Nícia Rosário-Ferreira; Catarina Marques-Pereira; Manuel Pires; Daniel Ramalhão; Nádia Pereira; Victor Guimarães; Vítor Santos Costa; Irina Sousa Moreira. "The Treasury Chest of Text Mining: Piling Available Resources for Powerful Biomedical Text Mining". BioChem 1 2 (2021): 60-80. https://doi.org/10.3390/biochem1020007.
    10.3390/biochem1020007
  7. Nícia Rosário-Ferreira; António J. Preto; Melo R.; Irina Moreira; Rui M. M. Brito. "The Central Role of Non-Structural Protein 1 (NS1) in Influenza Biology and Infection". International Journal of Molecular Sciences (2020): https://www.mdpi.com/1422-0067/21/4/1511.
    10.3390/ijms21041511
Thesis / Dissertation
  1. Nícia Filipa Rosário Ferreira. "Hair Metabolomics Applied to Gender Differentiation". Master, 2016. https://repositorio-aberto.up.pt/handle/10216/86299.

Other

Other output
  1. Arrestin and G Protein Interactions with GPCRs: A Structural Perspective. 2022. Carlos A.V. Barreto; Salete J. Baptista; Beatriz Bueschbell; Pedro R. Magalhães; António J. Preto; Agostinho Lemos; Nícia Rosário-Ferreira; et al. http://dx.doi.org/10.1002/9781119564782.ch5.
    10.1002/9781119564782.ch5
Activities

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2021 - Current Network and System Biology Biologia Celular e Molecular (Mestrado integrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2020/02 - Current Biomedical Text-Mining Biologia Celular e Molecular (Mestrado integrado) CNC.IBILI, Portugal
2020 - Current Biomedical Text-Mining PDBBEB - PhD Programme in Experimental Biology and Biomedicine (Doutoramento) Universidade de Coimbra, Portugal

CNC.IBILI, Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2022/01 Proteína de membrana SARS-CoV-2: de dados genómicos a novos conhecimentos estruturais EuroCC Portugal
2021/10 Projeto sobre doenças neurológicas vence prémio da Agência Nacional de Inovação
Distinctions

Award

2023 RCE+ awards five awards to young entrepreneurship projects
Região de Coimbra Empreende+, Portugal, Portugal
2023 Ineo start Acceleration Program
Instituto Pedro Nunes, Portugal
2021 Born from Knowledge 2021 "Health and Wellbeing"
Agência Nacional de Inovação SA, Portugal
2017 PhD Fellowship
Fundação para a Ciência e a Tecnologia, Portugal
2014 Melhor Aluna da Licenciatura 2014
Instituto Universitário de Ciências da Saúde, Portugal

Other distinction

2024 InvestEU Portal e-Pitch – Women entrepreneurs – one of the five selected at the European level.
Bpifrance, France
2022 BfK Acceleration Program: INNOV@RISE
Agência Nacional de Inovação SA, Portugal
2022 Selected for HiTech 2022 program