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I have started my research career studying transthyretin amyloidosis, developing new anti-TTR monoclonal antibodies and exploring their use in the diagnosis and therapy of the disease. Based on this early work, anti-TTR immunosorbents were used the 90s in a pilot trial of immunoapheresis for the treatment of the disease in 6 patients [Costa & Costa. Amyloid 1998;5:143-4]. I maintain an active interest in the study of the molecular pathology of amyloidosis [Beirão et al. Clin Nephrol. 2010;74:327-35; Moreira et al. Amyloid 2015;22:93-9]. In the last decade, my main interests were the study of epilepsy and autoimmune diseases, with a focus on genetic determinants of susceptibility, disease course and presentation, and their interaction with environmental factors [Bettencourt et al. J Immunol Res. 2015;2015:948723; Bettencourt et al. J Steroid Biochem Mol Biol. 2017 Sep 22. pii: S0960-0760(17)30264-9]. With the acquisition of in-house NGS capability, my main focus is now the exploration of the role of the microbiome in autoimmune disease.
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Identification

Personal identification

Full name
Paulo Manuel de Castro Pinho e Costa
Date of birth
1958/01/16
Gender
Male

Citation names

  • Costa, Paulo P
  • Costa, Paulo MP

Author identifiers

Ciência ID
6A17-F7BE-D4BC
ORCID iD
0000-0001-6125-7000
Researcher Id
B-4392-2008
Scopus Author Id
14023271500

Email addresses

  • paulo.costa@insa.min-saude.pt (Professional)

Telephones

Telephone
  • (+351) 22 340 110 Ext.: 2180 (Professional)

Addresses

  • INSA Dr. Ricardo Jorge. Rua Alexandre Herculano 321, 4000-053, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Immunology
  • Medical and Health Sciences - Basic Medicine - Pathology
  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Medical and Health Sciences - Basic Medicine - Human Genetics
Education
Degree Classification
1995
Concluded
 Ciências Biomédicas (Doutoramento)
Major in Outra:Patologia
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Amiloidoses Transtirretemicas da Biopatologia À Terapêutica" (THESIS/DISSERTATION)
1986 - 1991
Concluded
 Especialista em Anatomia Patológica (Especialização pós-licenciatura)
Ordem dos Médicos, Portugal
1982
Concluded
 Medicina (Licenciatura)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"-" (THESIS/DISSERTATION)
 13
Affiliation

Science

Category
Host institution 		Employer
2002 - Current Principal Investigator (Research) Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
1997 - 2002 Auxiliary Researcher (Research) Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2023 - Current Invited Associate Professor (University Teacher) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1997 - 2023 Invited Assistant Professor (University Teacher) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Projects

Contract

Designation Funders
2009 - 2011 The relevance of HHV-6B in patients with Mesial Temporal Lobe Epilepsy(MTLE) due to Hippocampal Sclerosis (HS): implications in prevention and treatment
PIC/IC/83297/2007
Researcher
Universidade do Porto Unidade Multidisciplinar de Investigação Biomédica, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
1997 - 2000 Desenvolvimento de imunoadsorventes de uso médico, de custo reduzido, com base em mini-anticorpos recombinantes de cadeia única
PRAXIS/PCNA/C/BIO/50/96
Principal investigator
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
 Fundação para a Ciência e a Tecnologia
Outputs

Publications

Book
  1. Vasconcelos, C.; Carvalho, C.; Leal, B.; Pereira, C.; Bettencourt, A.; Costa, P.P.; Marinho, A.; et al. HLA in Portuguese systemic lupus erythematosus patients and their relation to clinical features. 2009.
    10.1111/j.1749-6632.2009.04873.x
Book chapter
  1. Leal, Bárbara; Costa, Paulo P; Martins da Silva, Berta. "Genétca". In Epilepsia. Conceitos, Diagnóstico e Tratamento, edited by Pimentel, José; Bentes, Carla, 53-72. Lisboa, Portugal: Lidel - Edições Técnicas, Lda., 2016.
    Published
Conference abstract
  1. Carvalho, C; Leal, B; Bettencourt, A; Costa, A; Bras, S; Ramalheira, JEDP; Lopes, JMCF; et al. "Killer cell immunoglobulin-like receptor genes and sleep disorders in a Portuguese population". 2019.
  2. Leal, B; Bettencourt, A; Ferreira, AM; Carvalho, C; Moreira, I; Costa, PP; Da Silva, BM; Cavaco, S; Da Silva, AM. "IL1B rs16944 and depression symptoms in multiple sclerosis patients". 2017.
  3. Leal, B; Carvalho, C; Chaves, J; Bettencourt, A; Ferreira, R; Rangel, R; Santos, A; et al. "Inverse correlation between miR-22 serum levels and p2x7r-mediated inflammatory response in mesial temporal lobe epilepsy patients". 2017.
    10.1016/j.jns.2017.08.295
  4. Bettencourt, A; Leal, B; Ferreira, M; Carvalho, C; Moreira, I; Santos, E; Costa, PP; et al. "Depression symptoms in multiple sclerosis patients - The role of IL1B". 2017.
    10.1016/j.jns.2017.08.691
  5. Bettencourt, A; Boleixa, D; Sousa, AL; Santos, E; Marinho, A; Oliveira, JC; Reis, J; et al. "Vitamin D levels and severity in multiple sclerosis patients from the North of Portugal". 2016.
  6. Boleixa, D; Goncalves, A; Bettencourt, A; Leal, B; Carvalho, C; Bras, S; Mendes, A; et al. "Genetic variation in DRD3 and impulse control disorders in Parkinson's disease". 2015.
  7. Leal, B; Carvalho, C; Chaves, JMM; Bettencourt, A; Freitas, J; Lopes, JMCF; Ramalheira, JEDP; et al. "Expression of miR146-a, an inflammation-associated microRNA, in mesial temporal lobe epilepsy". 2015.
  8. Bettencourt, A; Silva, AM; Carvalho, C; Leal, B; Santos, E; Samoes, R; Costa, PP; Silva, BM. "Vitamin D status and vitamin D receptor gene Fok1 and Taq1 polymorphisms in Portuguese patients with multiple sclerosis". 2014.
  9. Leal, B; Chaves, J; Barreira, AC; Carvalho, C; Bettencourt, A; Lopes, J; Ramalheira, J; et al. "Is serotonin transporter implicated in mesial temporal lobe epilepsy development?". 2014.
  10. Chaves, J; Leal, B; Barreira, A; Carvalho, C; Bettencourt, A; Lopes, J; Ramalheira, J; et al. "SEROTONIN RECEPTORS IN MESIAL TEMPORAL LOBE EPILEPSY". 2014.
  11. Leal, B; Zenatti, L; Rangel, R; Chaves, J; Carvalho, C; Bettencourt, A; Santos, A; et al. "ADENOSINERGIC SYSTEM IN MESIAL TEMPORAL LOBE EPILEPSY". 2014.
  12. Ferreira, JCP; Torres, T; Carvalho, CA; Bettencourt, A; Leal, B; Vasconcelos, C; Costa, PP; Selores, M; Silva, BM. "Apoe isoforms in patients with psoriasis". 2013.
  13. Ferreira, JP; Torres, T; Carvalho, C; Bettencourt, A; Leal, B; Vasconcelos, C; Costa, PP; Selores, M; Silva, BM. "IL-6 and TNF-alpha polymorphisms in portuguese psoriatic patients". 2013.
  14. Martins da Silva, AM; Leal, B; Chaves, J; Carvalho, C; Bettencourt, A; Branco, RC; Ferreira, J; Costa, PP; Martins da Silva, BM. "APOE ISOFORMS IN FOCAL EPILEPSIES: AN ASSOCIATION STUDY IN A PORTUGUESE POPULATION". 2013.
  15. Chaves, J; Leal, B; Carvalho, C; Bettencourt, A; Bras, S; Barreira, A; Boleixa, D; et al. "MESIAL TEMPORAL LOBE EPILEPSY AND SEROTONIN: THE ROLE OF HTR2A RECEPTOR". 2013.
  16. Leal, B; Castelo Branco, RC; Rangel, R; Chaves, J; Carvalho, C; Bettencourt, A; Honavar, M; et al. "HUMAN HERPES VIRUS 6B AND MESIAL TEMPORAL LOBE EPILEPSY WITH HIPPOCAMPAL SCLEROSIS (MTLE-HS): IS THERE A LINK?". 2013.
  17. Neves, F; Abrantes, J; Costa, PP; Esteves, PJ. "Comparative evolutionary analysis of IL6 in lagomorphs". 2013.
  18. Lopes, A; Fonseca, M; Almeida, I; Perneta, F; Bettencourt, A; Carvalho, C; Marinho, A; et al. "HLA-DRB1 ALLELES AND AUTOANTIBODY PRODUCTION IN A PORTUGUESE SCLERODERMA COHORT". 2012.
  19. Bettencourt, A; Carvalho, C; Leal, B; Maia, S; Lopes, D; Fonseca, M; Almeida, I; et al. "ASSOCIATION OF HLA-DRB1 ALLELES AND AUTOANTIBODY PRODUCTION IN A PORTUGUESE SCLERODERMA COHORT". 2012.
  20. Carvalho, C; Bettencourt, A; Leal, B; Fonseca, M; Lopes, D; Perneta, F; Pestana, J; et al. "STUDY OF KIR GENES IN PORTUGUESE PATIENTS WITH SYSTEMIC SCLEROSIS". 2012.
  21. Martins Da Silva, AM; Branco, R; Leal, B; Rangel, R; Carvalho, C; Bettencourt, A; Chaves, J; et al. "ARE GLUTAMINE SINTHETASE EXPRESSION LEVELS ASSOCIATED WITH MESIAL TEMPORAL LOBE EPILEPSY WITH HIPPOCAMPAL SCLEROSIS?". 2012.
  22. Leal, B; Branco, R; Rangel, R; Bettencourt, A; Carvalho, C; Chaves, J; Santos, A; et al. "EXCITATORY AMINO ACID TRANSPORTER-1 EXPRESSION IN HUMAN MESIAL TEMPORAL LOBE EPILEPSY WITH HIPPOCAMPAL SCLEROSIS". 2012.
  23. Chaves, J; Brito, C; Leal, B; Carvalho, C; Bettencourt, A; Branco, R; Martins Da Silva, AM; Costa, PP; Martins Da Silva, BM. "INFLAMMATORY PROCESS AND MESIAL TEMPORAL LOBE EPILEPSY WITH EPILEPSY: THE ROLE OF IL-1 beta". 2012.
  24. Bettencourt, A; Silva, AM; Carvalho, C; Leal, B; Santos, E; Coutinho, E; Costa, PP; Silva, BM. "Fok1 vitamin D receptor gene polymorphism is associated with multiple sclerosis in a Portuguese population". 2011.
  25. Silva, AM; Bettencourt, A; Ribeiro, A; Goncalves, A; Pinto, C; Moreira, I; Santos, E; et al. "Dementia in multiple sclerosis: demographic, clinical and genetic features". 2011.
  26. Bettencourt, A; Silva, AM; Carvalho, C; Leal, B; Santos, E; Coutinho, E; Pinho e Costa, PPE; Silva, BM. "Vitamin D receptor gene Fok1 polymorphism in Portuguese patients with multiple sclerosis". 2011.
  27. Martins Silva, AM; Bettencourt, A; Goncalves, A; Pinto, C; Santos, E; Moreira, I; Tavares, A; et al. "Does APOE-epsilon4 have a detrimental effect in multiple sclerosis?". 2011.
  28. Branco, RC; Leal, B; Rangel, R; Chaves, J; Bettencourt, A; Carvalho, C; Lima, JL; et al. "EXPRESSION OF GLUTAMATE TRANSPORTERS IN HUMAN MESIAL TEMPORAL LOBE EPILEPSY WITH HIPOCAMPPAL SCLEROSIS: A PRELIMINARY STUDY". 2011.
  29. Leal, B; Carvalho, C; Bettencourt, A; Carneiro, P; Cerveira, C; Vasconcelos, C; Barbosa, P; Costa, PP; Silva, BM. "Killer immunoglobulin-like receptor genes and rheumatoid arthritis in a Portuguese population". 2011.
  30. Leal, B; Rangel, R; Carvalho, C; Moreira, L; Chaves, J; Silva, AM; Lima, JL; et al. "INFLAMMATION IN HUMAN MESIAL TEMPORAL LOBE EPILEPSY WITH HIPPOCAMPAL SCLEROSIS: PRELIMINARY EVALUATION". 2010.
  31. Carvalho, C; Lopes, D; Bettencourt, A; Leal, B; Maia, S; Vita, P; Almeida, F; et al. "Natural killer cell function and disease progression in Portuguese patients with HIV - an immunogenetic perspective". 2010.
  32. Bettencourt, A; Silva, AM; Carvalho, C; Coutinho, E; Santos, E; Pereira, C; Mendonca, D; Costa, PP; Silva, BM. "Killer immunoglobulin-like receptor genes in Portuguese multiple sclerosis patients". 2010.
  33. Leal, B; Rangel, R; Carvalho, C; Moreira, L; Chaves, J; Silva, AM; Lima, JL; et al. "Inflammation in human mesial temporal lobe epilepsy with hippocampal sclerosis: a preliminary evaluation". 2010.
  34. Leal, B; Carvalho, C; Bettencourt, A; Leuschner, P; Nery, F; Carneiro, P; Cerveira, C; et al. "CCR5 and rheumatoid arthritis: is there an association?". 2010.
  35. Leal, B; Chaves, J; Carvalho, C; Bettencourt, A; Barros, M; Lopes, D; Silva, AM; et al. "MDR1 GENE POLYMORPHISMS AND DRUG-RESISTANT EPILEPSY IN A PORTUGUESE POPULATION". 2010.
  36. Martins Da Silva, AM; Lacerda, P; Guedes, L; Lopes, J; Leal, B; Pinho e Costa, PPE; Martins da Silva, BM. "VARIATION OF JME FAMILY PHENOTYPE ANTICIPATED BY PREVIOUS EEG CHARACTERIZATION: CLINICAL AND GENETIC EXPLORATION". 2009.
  37. Leal, B; Chaves, J; Carvalho, C; Bettencourt, A; Barros, M; Pereira, C; Costa, PP; et al. "Predictive genetic risk factors for febrile seizures and mesial temporal lobe epilepsy". 2009.
  38. Carvalho, C; Duarte, R; Pereira, C; Bettencourt, A; Quintas, Z; Vilar, M; Domingos, A; Costa, PP; Silva, BM. "Is susceptibility and protection to tuberculosis KIR dependent?". 2009.
  39. Rodrigues, P; Pereira, C; Bettencourt, A; Carvalho, C; Leal, B; Torres, T; Lobo, I; et al. "KIR genes and HLA-Cw*0602 in Portuguese patients with Psoriasis vulgaris". 2009.
  40. Leal, B; Pereira, C; Carvalho, C; Bettencourt, A; Costa, PP; Leuschner, P; Nery, F; et al. "HLA-DRB1 and rheumatoid arthritis: the anti-CCP antibodies effect". 2009.
  41. Bettencourt, A; Martins Silva, AM; Pereira, C; Coutinho, E; Santos, E; Carvalho, C; Mendonca, D; et al. "Killer cell immunoglobulin-like receptors (KIR) genes and multiple sclerosis: possible roles in protection and susceptibility". 2009.
  42. Chaves, J; Bettencourt, A; Leal, B; Carvalho, C; Pereira, C; Costa, PP; Monteiro, L; et al. "ApoE polymorphisms and susceptibility to mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) in a Portuguese population". 2008.
  43. Bettencourt, A; Silva, AM; Santos, E; Pereira, C; Carvalho, C; Leal, B; Costa, PP; Monteiro, L; Silva, BM. "Role of HFE in disease course and susceptibility in a group of Portuguese multiple sclerosis patients". 2008.
  44. Silva, A; Bettencourt, A; Santos, E; Coutinho, E; Pereira, C; Carvalho, C; Mendonca, D; et al. "No evidence of increased genetic susceptibility to autoimmune diseases in Portuguese Multiple Sclerosis patients". 2008.
  45. Bettencourt, A; Silva, A; Pereira, C; Coutinho, E; Santos, E; Carvalho, C; Mendonca, D; et al. "Benign course in multiple sclerosis: Association with autoimmunity and the protein tyrosine phosphatase (PTPN22) 1858C > T gene pollymorphism". 2008.
  46. Riedstra, S; Leite, G; Ferreira, C; Gomes, FB; Costa, PMP; Ferreira, JPM. "Optimization of the expression of single-chain antibodies using different Escherichia coli systems". 2007.
    10.1016/j.jbiotec.2007.07.457
  47. Pereira, C; Leal, B; Carvalho, C; Bettencourt, A; Machado, A; Casimiro, S; Silva, AM; et al. "Evidence for the presence of a common protective DRB1 allele for aid in the Portuguese population". 2007.
  48. Bettencourt, A; Pereira, C; Silva, AM; Carvalho, C; Leal, B; Couto, AR; Quintas, Z; et al. "HLA-DRB1*15-DQB1*06 haplotype and multiple sclerosis in Portuguese patients". 2007.
  49. Riedstra, S; Cerejo, L; Bras, S; Costa, PMP; Ferreira, JPM. "Optimization of the conditions for the expression of an anti-transthyretin scFv in Pichia pastoris". 2007.
    10.1016/j.biotec.2007.07.917
  50. Moreira, L; Lobato, L; Tavares, I; Matos, C; Carvalho, E; Pinheiro, J; Costa, PP. "Fibrinogen A alpha-chain Glu526V amyloidosis in seven Portuguese families". 2006.
  51. Fonseca, I; Lobato, L; Santos, J; Beirao, I; Cunha, C; Oliveira, JC; Cabrita, A; Costa, PP. "Vitamin D deficiency and serum levels of parathyroid hormone in Portuguese patients with familial amyloidotic polyneuropathy (FAP, TTR V30M)". 2006.
  52. Pereira, C; Chaves, J; Leal, B; Carvalho, A; Bettencourt, C; Costa, P; Monteiro, L; et al. "GABBR1 polymorphisms in portuguese mesial temporal lobe epilepsy patients". 2006.
  53. Bettencourt, A; Pereira, C; Silva, AM; Carvalho, C; Quintas, Z; Costa, PP; Monteiro, L. "Protective influence on Multiple Sclerosis by HLA-A*02: a study in the Portuguese population". 2006.
  54. Pereira, C; Silva, AM; Pinto, D; Bettencourt, A; Costa, PP; Koeleman, B; Silva, BM. "The role of PTPN22 1858T autoimmunity risk variant in Multiple Sclerosis Portuguese population". 2006.
  55. Silva, AM; Bettencourt, A; Pereira, C; Carvalho, C; Casimiro, S; Costa, PP; Monteiro, L; Silva, BM. "HLA-A*02 allele as a modulating factor in multiple sclerosis: Implications for susceptibility and severity". 2006.
  56. Pereira, C; Martins da Silva, A; Pinto, D; Bettencourt, A; Costa, P; Koeleman, B; Martins da Silva, B. "The role of PTPN22 1858T autoimmunity risk variant in a Portuguese multiple sclerosis population". 2006.
  57. Silva, AM; Pereira, C; Bettencourt, A; Carvalho, C; Casimiro, S; Quintas, Z; Costa, PP; Monteiro, L; Silva, BM. "Influence of HLA-DRB1 in clinical course and disease severity in Portuguese MS patients". 2005.
  58. Pereira, C; Silva, AM; Carvalho, C; Bettencourt, A; Casimiro, S; Quintas, Z; Costa, PM; Monteiro, L; Silva, BM. "TNFA promoter polymrphisms in Portuguese multiple sclerosis patients". 2005.
  59. Pereira, C; Pereira, O; Escada, R; Pinto, D; Selores, M; Carvalho, C; Costa, P; Massa, A; Silva, B. "HLA-CW*0602 and TNFa in psoriasis patients". 2005.
  60. Pereira, C; Silva, AM; Carvalho, C; Bettencourt, A; Casimiro, S; Quintas, Z; Costa, PM; Monteiro, L; Silva, BM. "DR/DQ antigens in papillary thyroid tumors". 2005.
  61. Carvalho, C; Pereira, C; Duarte, R; Casimiro, S; Quintas, Z; Costa, PP; Silva, BM. "Genetic susceptibility to tuberculosis: Association with HLA class II and TNA-a alleles". 2005.
  62. Silva, AM; Pereira, C; Bettencourt, A; Carvalho, C; Lacerda, P; Costa, PP; Monteiro, L; da Silva, BM. "Genetic susceptibility to multiple sclerosis in Portuguese patients: A study of HLA and non HLA genes". 2005.
  63. Pereira, C; Paulo, P; Costa, PPE; Barbot, C; Santos, M; Ramalheira, J; Lopes, J; et al. "Association studies with GABA[B]R1 polymorphisms and idiopathic generalised epilepsy in Portuguese patients". 2004.
  64. Paulo, P; Pereira, C; Carvalho, C; Costa, PP; Lima, J; Casimiro, S; Quintas, Z; Silva, AM; Martins, B. "GABA(B)R1 polymorphisms and idiopathic generalized epilepsy in Portuguese patients". 2004.
Journal article
  1. João Chaves; Bárbara Leal; Ana Sardoeira; Vanessa Carvalho; Raquel Samões; Joel Freitas; Rui Chorão; et al. "Different relationships between epilepsy syndromes and autoimmune diseases". Epileptic Disorders 25 1 (2023): 33-44. http://dx.doi.org/10.1002/epd2.20048.
    10.1002/epd2.20048
  2. Ricardo Martins-Ferreira; Bárbara Leal; João Chaves; Laura Ciudad; Raquel Samões; António Martins da Silva; Paulo Pinho Costa; Esteban Ballestar. "Circulating cell-free DNA methylation mirrors alterations in cerebral patterns in epilepsy". Clinical Epigenetics 14 1 (2022): http://dx.doi.org/10.1186/s13148-022-01416-2.
    10.1186/s13148-022-01416-2
  3. Ricardo Martins-Ferreira; Bárbara Leal; João Chaves; Tianlu Li; Laura Ciudad; Rui Rangel; Agostinho Santos; et al. "Epilepsy progression is associated with cumulative DNA methylation changes in inflammatory genes". Progress in Neurobiology 209 (2022): 102207-102207. https://doi.org/10.1016/j.pneurobio.2021.102207.
    10.1016/j.pneurobio.2021.102207
  4. Leal, BG; Barros Barbosa, A; Ferreirinha, F; Chaves, J; Rangel, R; Santos, A; Carvalho, C; et al. "Mesial Temporal Lobe Epilepsy (MTLE) Drug-Refractoriness Is Associated With P2X7 Receptors Overexpression in the Human Hippocampus and Temporal Neocortex and May Be Predicted by Low Circulating Levels of miR-22". FRONTIERS IN CELLULAR NEUROSCIENCE (2022):
    10.3389/fncel.2022.910662
  5. Ferreira, A.M.; Leal, B.; Ferreira, I.; Brás, S.; Moreira, I.; Samões, R.; Sousa, A.P.; et al. "Depression and anxiety in multiple sclerosis patients: The role of genetic variability of interleukin 1ß". Multiple Sclerosis and Related Disorders 52 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85105808028&partnerID=MN8TOARS.
    10.1016/j.msard.2021.102982
  6. Leal, B.; Carvalho, C.; Ferreira, A.M.; Nogueira, M.; Brás, S.; Silva, B.M.; Selores, M.; Costa, P.P.; Torres, T.. "Serum Levels of miR-146a in Patients with Psoriasis". Molecular Diagnosis and Therapy 25 4 (2021): 475-485. http://www.scopus.com/inward/record.url?eid=2-s2.0-85105395705&partnerID=MN8TOARS.
    10.1007/s40291-021-00531-9
  7. Martins-Ferreira R; Leal B; Costa PP; Ballestar E. "Microglial innate memory and epigenetic reprogramming in neurological disorders.". Progress in neurobiology (2020): http://europepmc.org/abstract/med/33309803.
    10.1016/j.pneurobio.2020.101971
  8. Chaves J; Martins-Ferreira R; Ferreira AM; Brás S; Carvalho C; Bettencourt A; Samões R; et al. "Immunogenetic protective factors in Genetic Generalized Epilepsy.". Epilepsy research (2020): http://europepmc.org/abstract/med/32585211.
    10.1016/j.eplepsyres.2020.106396
  9. Martins-Ferreira, R.; Chaves, J.; Carvalho, C.; Bettencourt, A.; Chorão, R.; Freitas, J.; Samões, R.; et al. "Circulating microRNAs as potential biomarkers for genetic generalized epilepsies: a three microRNA panel". European Journal of Neurology 27 4 (2020): 660-666. http://dx.doi.org/10.1111/ene.14129.
    Published • 10.1111/ene.14129
  10. Nuno Gomes; André Cerejeira; Elisabete Moreira; Catarina Costa; Paulo Pinho e Costa; Filomena Azevedo. "Rhinophyma or something more?". International Journal of Dermatology (2020): https://doi.org/10.1111/ijd.14825.
    10.1111/ijd.14825
  11. Chaves, João; Martins-Ferreira, Ricardo; Carvalho, Cláudia; Bettencourt, Andreia; Brás, Sandra; Chorão, Rui; Freitas, Joel; et al. "Apolipoprotein E isoforms and susceptibility to genetic generalized epilepsies". International Journal of Neuroscience (2020): 1-6. http://dx.doi.org/10.1080/00207454.2019.1709840.
    Published • 10.1080/00207454.2019.1709840
  12. Martins E; Urbano J; Leite S; Pinto A; Garcia R; Bergantim R; Rodrigues-Pereira P; et al. "Cardiac Amyloidosis Associated with Apolipoprotein A-IV Deposition Diagnosed by Mass Spectrometry-Based Proteomic Analysis.". European journal of case reports in internal medicine (2019): http://europepmc.org/abstract/med/31893197.
    10.12890/2019_001237
  13. Santos, Ernestina; Bettencourt, Andreia; Duarte, Sara; Gabriel, Denis; Oliveira, Vanessa; da Silva, Ana Martins; Costa, Paulo Pinho; et al. "Refractory myasthenia gravis: Characteristics of a portuguese cohort". Muscle & Nerve 60 2 (2019): 188-191. http://dx.doi.org/10.1002/mus.26507.
    Published • 10.1002/mus.26507
  14. Tavares, Isabel; Oliveira, Márcia E.; Maia, Nuno; Moreira, Luciana; Castro Lacerda, Pedro; Santos, Josefina; Santos, Rosário; Pinho Costa, Paulo; Lobato, Luísa. "Haplotype analysis of newly diagnosed Portuguese and Brazilian families with fibrinogen amyloidosis caused by the FGA p.Glu545Val variant". Amyloid 26 sup1 (2019): 144-145. http://dx.doi.org/10.1080/13506129.2019.1582500.
    Published • 10.1080/13506129.2019.1582500
  15. Tavares, Isabel; Silvano, José; Moreira, Luciana; Oliveira, Márcia E.; Silva, Roberto; Sampaio, Susana; Costa, Paulo Pinho; Lobato, Luísa. "Short-term complications after renal transplantation in AFibE526V (p.Glu545Val) amyloidosis". Amyloid 26 sup1 (2019): 162-163. http://dx.doi.org/10.1080/13506129.2019.1583196.
    Published • 10.1080/13506129.2019.1583196
  16. Costa, Paulo. "Estrogen Metabolism-Associated CYP2D6 and IL6-174G/C Polymorphisms in Schistosoma haematobium Infection". International Journal of Molecular Sciences (2017): http://www.mdpi.com/1422-0067/18/12/2560.
    10.3390/ijms18122560
  17. Leal B; Chaves J; Carvalho C; Rangel R; Santos A; Bettencourt A; Lopes J; et al. "Brain expression of inflammatory mediators in Mesial Temporal Lobe Epilepsy patients.". Journal of neuroimmunology (2017): http://europepmc.org/abstract/med/29153613.
    10.1016/j.jneuroim.2017.10.014
  18. Bárbara Leal; João Chaves; Cláudia Carvalho; Andreia Bettencourt; Joel Freitas; João Lopes; João Ramalheira; et al. "Age of onset of mesial temporal lobe epilepsy with hippocampal sclerosis: the effect of apolipoprotein E and febrile seizures". International Journal of Neuroscience 127 9 (2017): 800-804. https://doi.org/10.1080%2F00207454.2016.1264396.
    10.1080/00207454.2016.1264396
  19. Costa, Paulo. "Serum 25-hydroxyvitamin D levels in multiple sclerosis patients from the north of Portugal.". The Journal of steroid biochemistry and molecular biology (2017): http://europepmc.org/abstract/med/28951256.
    10.1016/j.jsbmb.2017.09.016
  20. Costa, Paulo. "The vitamin D receptor gene FokI polymorphism and Multiple Sclerosis in a Northern Portuguese population.". Journal of neuroimmunology (2017): http://europepmc.org/abstract/med/28601283.
    10.1016/j.jneuroim.2017.05.005
  21. Costa, Paulo. "Unrecognized Fibrinogen A a-Chain Amyloidosis: Results From Targeted Genetic Testing.". American journal of kidney diseases : the official journal of the National Kidney Foundation (2017): http://europepmc.org/abstract/med/28359658.
    10.1053/j.ajkd.2017.01.048
  22. Costa, Paulo. "HLA and age of onset in myasthenia gravis.". Neuromuscular disorders : NMD (2017): http://europepmc.org/abstract/med/28495048.
    10.1016/j.nmd.2017.04.002
  23. Costa, Paulo. "Immunogenetic Predisposing Factors for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis.". The International journal of neuroscience (2017): http://europepmc.org/abstract/med/28675059.
    10.1080/00207454.2017.1349122
  24. Costa, Paulo. "Fibrinogen A alpha-chain amyloidosis: a non-negligible cause of chronic kidney disease in dialysis patients.". Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis (2017): http://europepmc.org/abstract/med/28434302.
    10.1080/13506129.2017.1281119
  25. Costa, Paulo. "Vitamin D supplementation effects on FoxP3 expression in T cells and FoxP3+/IL-17A ratio and clinical course in systemic lupus erythematosus patients: a study in a Portuguese cohort.". Immunologic research (2017): http://europepmc.org/abstract/med/27423437.
    10.1007/s12026-016-8829-3
  26. Costa, Paulo. "Serum 25-hydroxyvitamin D levels in a healthy population from the North of Portugal.". The Journal of steroid biochemistry and molecular biology (2016): http://europepmc.org/abstract/med/27825978.
    10.1016/j.jsbmb.2016.11.005
  27. Torres, T.; Bettencourt, N.; Ferreira, J.; Carvalho, C.; Mendonça, D.; Pinho-Costa, P.; Vasconcelos, C.; Selores, M.; Silva, B.. "Influence of TNF-a gene polymorphisms in coronary artery calcification in psoriasis patients". Journal of the European Academy of Dermatology and Venereology 30 1 (2016): 191-193. http://www.scopus.com/inward/record.url?eid=2-s2.0-84954531180&partnerID=MN8TOARS.
    10.1111/jdv.12706
  28. Neves F; Abrantes J; Almeida T; de Matos AL; Costa PP; Esteves PJ. "Genetic characterization of interleukins (IL-1a, IL-1ß, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18) with relevant biological roles in lagomorphs.". (2015): http://europepmc.org/abstract/med/26395994.
    10.1177/1753425915606209
  29. Lacerda PC; Moreira L; Vitorino R; Costa PP. "Use of MALDI-TOF Mass Spectrometry to Assay the Transthyretin V30M Mutation in Serum From a Liver Transplant Donor: A Case Report.". (2015): http://europepmc.org/abstract/med/25943235.
    10.1097/TP.0000000000000658
  30. Carvalho C; Marinho A; Leal B; Bettencourt A; Boleixa D; Almeida I; Farinha F; et al. "Association between vitamin D receptor (VDR) gene polymorphisms and systemic lupus erythematosus in Portuguese patients.". (2015): http://europepmc.org/abstract/med/25661837.
  31. Torres T; Bettencourt N; Ferreira J; Carvalho C; Mendonça D; Pinho-Costa P; Vasconcelos C; Selores M; Silva B. "Influence of interleukin-6 gene polymorphisms in epicardial adipose tissue and coronary artery calcification in patients with psoriasis.". (2015): http://europepmc.org/abstract/med/25040543.
    10.1111/bjd.13271
  32. Bettencourt A; Carvalho C; Leal B; Brás S; Lopes D; Martins da Silva A; Santos E; et al. "The Protective Role of HLA-DRB1(*)13 in Autoimmune Diseases.". (2015): http://europepmc.org/abstract/med/26605347.
    10.1155/2015/948723
  33. Neves F; Abrantes J; Almeida T; Costa PP; Esteves PJ. "Evolutionary Insights into IL17A in Lagomorphs.". (2015): http://europepmc.org/abstract/med/26788019.
    10.1155/2015/367670
  34. Domingos J; Ferrão C; Ramalho J; Rodrigues T; Moreira B; Santos E; Bettencourt A; et al. "Characteristics of Neuro-Behcet's Disease in a Case-Series from a Single Centre in Northern Portugal.". (2015): http://europepmc.org/abstract/med/25997636.
    10.1159/000381210
  35. Beirão JM; Malheiro J; Lemos C; Beirão I; Costa P; Torres P. "Ophthalmological manifestations in hereditary transthyretin (ATTR V30M) carriers: a review of 513 cases.". (2015): http://europepmc.org/abstract/med/26096568.
    10.3109/13506129.2015.1015678
  36. Moreira L; Beirão JM; Beirão I; Pinho e Costa P. "Oligomeric TTR V30M aggregates compromise cell viability, erythropoietin gene expression and promoter activity in the human hepatoma cell line Hep3B.". (2015): http://europepmc.org/abstract/med/26088020.
    10.3109/13506129.2015.1007497
  37. Carvalho, C.; Marinho, A.; Leal, B.; Bettencourt, A.; Boleixa, D.; Almeida, I.; Farinha, F.; et al. "Association between vitamin D receptor (VDR) gene polymorphisms and systemic lupus erythematosus in Portuguese patients". Lupus 24 8 (2015): 846-853. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930886919&partnerID=MN8TOARS.
    10.1177/0961203314566636
  38. Silva, L.; Lopes, J.; Ramalheira, J.; Cunha, D.; Carvalho, C.; Bettencourt, A.; Brás, S.; et al. "Obstructive sleep apnoea syndrome and HLA in the North of Portugal,Síndrome de apnea obstructiva del sueño y HLA en el norte de Portugal". Revista de Neurologia 61 7 (2015): 301-307. http://www.scopus.com/inward/record.url?eid=2-s2.0-84942897710&partnerID=MN8TOARS.
    10.33588/rn.6107.2015199
  39. Beirão JM; Malheiro J; Lemos C; Matos E; Beirão I; Pinho-Costa P; Torres P. "Impact of liver transplantation on the natural history of oculopathy in Portuguese patients with transthyretin (V30M) amyloidosis.". (2014): http://europepmc.org/abstract/med/25475560.
    10.3109/13506129.2014.989318
  40. Neves F; Abrantes J; Pinheiro A; Almeida T; Costa PP; Esteves PJ. "Convergent evolution of IL-6 in two leporids (Oryctolagus and Pentalagus) originated an extended protein.". (2014): http://europepmc.org/abstract/med/25027474.
    10.1007/s00251-014-0787-0
  41. Torres T; Bettencourt N; Ferreira J; Carvalho C; Mendonça D; Pinho-Costa P; Vasconcelos C; Selores M; Silva B. "Influence of TNF-a gene polymorphisms in coronary artery calcification in psoriasis patients.". (2014): http://europepmc.org/abstract/med/25174782.
  42. Bettencourt A; Silva AM; Carvalho C; Leal B; Santos E; Costa PP; Silva BM. "The role of KIR2DS1 in multiple sclerosis--KIR in Portuguese MS patients.". (2014): http://europepmc.org/abstract/med/24529855.
    10.1016/j.jneuroim.2014.01.009
  43. Martins-da-Silva A; Lopes J; Ramalheira J; Carvalho C; Cunha D; Costa PP; Silva MB. "Usefulness of genetic characterization of narcolepsy and hypersomnia on phenotype definition: a study in Portuguese patients.". (2014): http://europepmc.org/abstract/med/24399620.
    10.33588/rn.5802.2013361
  44. Bettencourt A; Leal B; Carvalho C; Oliveira R; Martins Silva A; Vaz Patto J; Bastos M; et al. "CC chemokine receptor polymorphism CCR5¿32 in Portuguese Behcet's disease patients.". (2014): http://europepmc.org/abstract/med/25268662.
  45. Carvalho, C.; Calvisi, S.L.; Leal, B.; Bettencourt, A.; Marinho, A.; Almeida, I.; Farinha, F.; et al. "CCR5-Delta32: implications in SLE development". International journal of immunogenetics 41 3 (2014): 236-241. http://www.scopus.com/inward/record.url?eid=2-s2.0-85027939983&partnerID=MN8TOARS.
    10.1111/iji.12094
  46. Beirão JM; Moreira LM; Oliveira JC; Menéres MJ; Pessoa BB; Matos ME; Costa PP; Torres PA; Beirão IB. "Aqueous humor erythropoietin levels in open-angle glaucoma patients with and without TTR V30M familial amyloid polyneuropathy.". (2014): http://europepmc.org/abstract/med/25018619.
  47. Beirão, N.M.; Miranda, V.; Beirão, I.; Costa, P.P.; Torres, P.. "The use of intravitreal ranibizumab to treat neovascular glaucoma because of retinal amyloid angiopathy in familial amyloidosis transthyretin v30m related". Retinal Cases and Brief Reports 7 1 (2013): 114-116. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878093576&partnerID=MN8TOARS.
    10.1097/ICB.0b013e3182681259
  48. Kasperaviciute, D.; Catarino, C.B.; Matarin, M.; Leu, C.; Novy, J.; Tostevin, A.; Leal, B.; et al. "Epilepsy, hippocampal sclerosis and febrile seizures linked by common genetic variation around SCN1A". Brain 136 10 (2013): 3140-3150. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884838178&partnerID=MN8TOARS.
    10.1093/brain/awt233
  49. Beirão, J.M.; Matos, M.E.; Beirão, I.B.; Costa, P.P.; Torres, P.A.; Beirão, João M.; Matos, Maria E.; et al. "Topical cyclosporine for severe dry eye disease in liver-transplanted Portuguese patients with familial amyloidotic polyneuropathy (ATTRV30M)". European Journal of Ophthalmology 23 2 (2013): 156-163. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874171172&partnerID=MN8TOARS.
    Published • 10.5301/ejo.5000197
  50. Beirão M; Matos E; Beirão I; Pinho-Costa P; Torres P. "No ocular involvement in familial amyloidotic polyneuropathy ATTR V30M domino liver recipients.". (2012): http://europepmc.org/abstract/med/22443165.
    10.1111/j.1432-2277.2012.01467.x
  51. Bettencourt A; Martins da Silva A; Pinho E Costa P; Martins Silva B. "Molecular genetic studies of multiple sclerosis in the portuguese population.". (2012): http://europepmc.org/abstract/med/23079250.
  52. Bettencourt, A.; Martins Da Silva, A.; Pinho E Costa, P.; Martins Silva, B.. "Molecular genetic studies of multiple sclerosis in the Portuguese population | Estudos genéticos em doentes Portugueses com esclerose múltipla". Acta Medica Portuguesa 25 4 (2012): 224-230. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867909675&partnerID=MN8TOARS.
  53. Beirão, N.M.; Matos, M.E.; Meneres, M.J.; Beirão, I.M.; Costa, P.P.; Torres, P.A.. "Vitreous surgery impact in glaucoma development in liver transplanted familial amyloidosis ATTR V30M Portuguese patients". Amyloid 19 3 (2012): 146-151. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865218034&partnerID=MN8TOARS.
    10.3109/13506129.2012.710669
  54. Beirão, J.M.; Moreira, L.V.; Lacerda, P.C.; Vitorino, R.P.; Beirão, I.B.; Torres, P.A.; Costa, P.P.. "Inability of mutant transthyretin V30M to cross the blood-eye barrier". Transplantation 94 8 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84868139951&partnerID=MN8TOARS.
    10.1097/TP.0b013e318269e6d1
  55. Beirão, M.; Matos, E.; Reis, R.; Beirão, I.; Costa, P.P.; Torres, P.. "Spatial visual contrast sensitivity in liver transplanted Portuguese familial amyloidotic polyneuropathy (ATTR V30M) patients". Amyloid 19 3 (2012): 152-155. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865205684&partnerID=MN8TOARS.
    10.3109/13506129.2012.712075
  56. Beirão, M.; Matos, E.; Beirâo, I.; Costa, P.P.E.; Torres, P.. "Anticipation of presbyopia in Portuguese familial amyloidosis ATTR V30M". Amyloid 18 3 (2011): 92-97. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052190905&partnerID=MN8TOARS.
    10.3109/13506129.2011.576719
  57. Tavares, I.; Lobato, L.; Moreira, L.; Santos, J.; Lacerda, P.; Pinheiro, J.; Costa, P.. "Long-term follow-up of patients with hereditary fibrinogen A alpha-chain amyloidosis.". Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 18 Suppl 1 (2011): 216-217. http://www.scopus.com/inward/record.url?eid=2-s2.0-82255165417&partnerID=MN8TOARS.
    10.3109/13506129.2011.627069
  58. Beirão, N.M.; Matos, E.; Beirão, I.; Costa, P.P.; Torres, P.. "Recurrence of vitreous amyloidosis and need of surgical reintervention in portuguese patients with familial amyloidosis ATTR V30M". Retina 31 7 (2011): 1373-1377. http://www.scopus.com/inward/record.url?eid=2-s2.0-79961208874&partnerID=MN8TOARS.
    10.1097/IAE.0b013e318203c0c2
  59. Duarte, R.; Carvalho, C.; Pereira, C.; Bettencourt, A.; Carvalho, A.; Villar, M.; Domingos, A.; et al. "HLA class II alleles as markers of tuberculosis susceptibility and resistance | O papel do HLA classe II na susceptibilidade/resistência à tuberculose". Revista Portuguesa de Pneumologia 17 1 (2011): 15-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955665023&partnerID=MN8TOARS.
    10.1016/S0873-2159(11)70005-8
  60. Bettencourt, A.; Silva, A.M.; Santos, E.; Gomes, S.; Mendonça, D.; Costa, P.P.; Faustino, P.; Silva, B.M.. "HFE gene polymorphisms and severity in Portuguese patients with multiple sclerosis". European Journal of Neurology 18 4 (2011): 663-666. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952725496&partnerID=MN8TOARS.
    10.1111/j.1468-1331.2010.03109.x
  61. Duarte, R.; Carvalho, C.; Pereira, C.; Bettencourt, A.; Carvalho, A.; Villar, M.; Domingos, A.; et al. "HLA class II alleles as markers of tuberculosis susceptibility and resistance,O papel do HLA classe II na susceptibilidade/resistência À tuberculose". Revista Portuguesa de Pneumologia (English Edition) 17 1 (2011): 15-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-85038619284&partnerID=MN8TOARS.
    10.1016/S2173-5115(11)70005-7
  62. Tavares, I.; Lobato, L.; Moreira, L.; Santos, J.; Lacerda, P.; Pinheiro, J.; Costa, P.. "Long-term follow-up of patients with hereditary fibrinogen A alpha-chain amyloidosis". Amyloid 18 SUPPL. 1 (2011): 221-222. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960023250&partnerID=MN8TOARS.
    10.3109/13506129.2011.574354
  63. Beirão, I.; Moreira, L.; Barandela, T.; Lobato, L.; Silva, P.; Gouveia, C.M.; Carneiro, F.; et al. "Erythropoietin production by distal nephron in normal and familial amyloidotic adult human kidneys". Clinical Nephrology 74 5 (2010): 327-335. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649902510&partnerID=MN8TOARS.
  64. Silva, A.M.; Bettencourt, A.; Pereira, C.; Santos, E.; Carvalho, C.; Mendonça, D.; Costa, P.P.; Monteiro, L.; Martins, B.. "Protective role of the HLA-A*02 allele in Portuguese patients with multiple sclerosis". Multiple Sclerosis 15 6 (2009): 771-774. http://www.scopus.com/inward/record.url?eid=2-s2.0-66249137162&partnerID=MN8TOARS.
    10.1177/1352458509104588
  65. Bettencourt, A.; Pereira, C.; Carvalho, L.; Carvalho, C.; Patto, J.V.; Bastos, M.; Silva, A.M.; et al. "New insights of HLA class I association to Behçet's disease in Portuguese patients". Tissue Antigens 72 4 (2008): 379-382. http://www.scopus.com/inward/record.url?eid=2-s2.0-51649106008&partnerID=MN8TOARS.
    10.1111/j.1399-0039.2008.01087.x
  66. Beirão, I.; Moreira, L.; Porto, G.; Lobato, L.; Fonseca, I.; Cabrita, A.; Costa, P.M.P.. "Low erythropoietin production in familial amyloidosis TTR V30M is not related with renal congophilic amyloid deposition: A clinicopathologic study of twelve cases". Nephron - Clinical Practice 109 2 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-48249126810&partnerID=MN8TOARS.
    10.1159/000142527
  67. Beirão, I.; Almeida, S.; Swinkels, D.; Costa, P.M.P.; Moreira, L.; Fonseca, I.; Freitas, C.; Cabrita, A.; Porto, G.. "Low serum levels of prohepcidin, but not hepcidin-25, are related to anemia in familial amyloidosis TTR V30M". Blood Cells, Molecules, and Diseases 41 2 (2008): 175-178. http://www.scopus.com/inward/record.url?eid=2-s2.0-48749088914&partnerID=MN8TOARS.
    10.1016/j.bcmd.2008.04.008
  68. Beirão, I.; Lobato, L.; Costa, P.M.P.; Fonseca, I.; Silva, M.; Bravo, F.; Cabrita, A.; Porto, G.. "Liver transplantation and anemia in familial amyloidosis ATTR V30M". Amyloid 14 1 (2007): 33-37. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947645336&partnerID=MN8TOARS.
    10.1080/13506120601116476
  69. Silva, A.M.; Pereira, C.; Bettencourt, A.; Carvalho, C.; Couto, A.R.; Leite, M.I.; Marta, M.; et al. "The role of HLA-DRB1 alleles on susceptibility and outcome of a Portuguese Multiple Sclerosis population". Journal of the Neurological Sciences 258 1-2 (2007): 69-74. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249880485&partnerID=MN8TOARS.
    10.1016/j.jns.2007.02.033
  70. Pinho e Costa, P.. "A brief history of the Portuguese Amyloid Research Centre | Breve história do Centro de Estudos de Paramiloidose". Sinapse 6 1 SUPPL. 1 (2006): 180-183. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745375045&partnerID=MN8TOARS.
  71. Costa, P.P.. "The molecular diagnosis in familial amyloidotic polyneuropathy | Diagnóstico molecular da polineuropatia amiloidótica familiar". Sinapse 6 1 SUPPL. 1 (2006): 138-142. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745431694&partnerID=MN8TOARS.
  72. Almeida, V.M.; Costa, P.M.; Moreira, P.; Gonçalves, J.; Braga, J.; Costa, Paulo P. "Birth of two healthy females after preimplantation genetic diagnosis for familial amyloid polyneuropathy". Reproductive BioMedicine Online 10 5 (2005): 641-644. http://www.scopus.com/inward/record.url?eid=2-s2.0-18444397475&partnerID=MN8TOARS.
    10.1016/s1472-6483(10)61672-0
  73. Moura, E.; Pinho Costa, P.M.; Moura, D.; Guimarães, S.; Vieira-Coelho, M.A.. "Decreased tyrosine hydroxylase activity in the adrenals of spontaneously hypertensive rats". Life Sciences 76 25 (2005): 2953-2964. http://www.scopus.com/inward/record.url?eid=2-s2.0-16844380955&partnerID=MN8TOARS.
    10.1016/j.lfs.2004.11.017
  74. Beirão, I.; Lobato, L.; Costa, P.M.; Fonseca, I.; Mendes, P.; Silva, M.; Bravo, F.; et al. "Kidney and anemia in familial amyloidosis type I.". Kidney international 66 5 (2004): 2004-2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-21644479059&partnerID=MN8TOARS.
    10.1111/j.1523-1755.2004.00971.x
  75. Silva, B.M.; Thorlacius, T.; Benediktsson, K.; Pereira, C.; Fossdal, R.; Jonsson, H.H.; Silva, A.; et al. "A whole genome association study in multiple sclerosis patients from north Portugal". Journal of Neuroimmunology 143 1-2 (2003): 116-119. http://www.scopus.com/inward/record.url?eid=2-s2.0-10744219785&partnerID=MN8TOARS.
    10.1016/j.jneuroim.2003.08.024
  76. Fiszman, M.L.; Di Egidio, M.; Ricart, K.C.; Repetto, M.G.; Borodinsky, L.N.; Llesuy, S.F.; Saizar, R.D.; et al. "Evidence of oxidative stress in familial amyloidotic polyneuropathy type 1". Archives of Neurology 60 4 (2003): 593-597. http://www.scopus.com/inward/record.url?eid=2-s2.0-0344406277&partnerID=MN8TOARS.
    10.1001/archneur.60.4.593
  77. Pereira, C; Pinto, D; Pereira, O; Farinha, F; Massa, A; Cerqueira, J; Pauperio, S; et al. "Psoriasis and psoriatic arthritis: A possible modifying influence of a non-HLA gene in an HLA class I associated disease". European Journal of Immunogenetics (2001):
  78. Adams, D.; Samuel, D.; Goulon-Goeau, C.; Nakazato, M.; Costa, P.M.P.; Feray, C.; Planté, V.; et al. "The course and prognostic factors of familial amyloid polyneuropathy after liver transplantation". Brain 123 7 (2000): 1495-1504. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033919415&partnerID=MN8TOARS.
    10.1093/brain/123.7.1495
  79. Beirão, I.; Lobato, L.; Riedstra, S.; Costa, P.M.P.; Pimentel, S.; Guimarães, S.; Costa, Paulo P. "Ineffectiveness of dialysis in transthyretin (TTR) clearance in Familial Amyloid Polyneuropathy type I, in spite of lower stability of the TTR Met30 variant". Clinical Nephrology 51 1 (1999): 45-49. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032924669&partnerID=MN8TOARS.
  80. Costa, Paulo P; Beirão, I.; Lobato, L.; Guimarães, S.M.; Cardoso, P.; Costa, P.M.P.; Coelho, T.; Rocha, G.; Guimarães, S.. "Early destructive spondyloarthropathy from combined beta2-microglobulin and transthyretin Met30 amyloidosis in a dialysed patient.". Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 13 12 (1998): 3223-3225. http://europepmc.org/abstract/med/9870498.
    10.1093/ndt/13.12.3223
  81. Costa PM; Costa PP. "The future of selective apheresis in FAP.". (1998): http://europepmc.org/abstract/med/9686308.
    10.3109/13506129808995291
  82. Costa, Paulo P; Riedstra, S.; Ferreira, J.P.M.; Costa, P.M.P.. "Study of an anti-human transthyretin immunoadsorbent. Influence of coupling chemistry on binding capacity and ligand leakage.". Journal of chromatography. B, Biomedical sciences and applications 705 2 (1998): 213-222. http://europepmc.org/abstract/med/9521557.
    10.1016/S0378-4347(97)00546-X
  83. Ando, Y.; Anan, I.; Suhr, O.; Holmgren, G.; Costa, P.M.P.; Costa, Paulo P. "Detection of a variant protein in hair: New diagnostic method in Portuguese type familial amyloid polyneuropathy". British Medical Journal 316 7143 (1998): 1500-1501. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032537367&partnerID=MN8TOARS.
    10.1136/bmj.316.7143.1500
  84. Vallar, L.; Costa, P.M.P.; Teixeira, A.; Pfister, M.; Barrois, R.; Costa, P.P.; Rivat, C.. "Immunoadsorption procedure as a potential method for the specific ß2-microglobulin removal from plasma of patients with chronic renal failure". Journal of Chromatography B: Biomedical Applications 664 1 (1995): 97-106. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028890103&partnerID=MN8TOARS.
    10.1016/0378-4347(94)00402-Q
  85. Costa, Paulo P; Holmgren, G.; Costa, P.M.P.; Andersson, C.; Asplund, K.; Steen, L.; Beckman, L.; et al. "Geographical distribution of TTR met30 carriers in northern Sweden: discrepancy between carrier frequency and prevalence rate.". Journal of medical genetics 31 5 (1994): 351-354. http://europepmc.org/abstract/med/8064809.
    10.1136/jmg.31.5.351
  86. López Andreu FR; Munar-Qués M; Parrilla P; Escribano Soriano JB; Costa PP; Costa PM; Almeida MR; et al. "[Liver transplantation for the treatment of type I familial amyloidotic polyneuropathy]". (1993): http://europepmc.org/abstract/med/8255113.
  87. Costa PM; Teixeira A; Saraiva MJ; Costa PP. "Immunoassay for transthyretin variants associated with amyloid neuropathy.". (1993): http://europepmc.org/abstract/med/8394031.
    10.1111/j.1365-3083.1993.tb01710.x
  88. Saraiva MJ; Almeida Mdo R; Sherman W; Gawinowicz M; Costa P; Costa PP; Goodman DS. "A new transthyretin mutation associated with amyloid cardiomyopathy.". (1992): http://europepmc.org/abstract/med/1570831.
  89. Regnault V; Costa PM; Teixeira A; Rivat C; Stoltz JF; Saraiva MJ; Costa PP. "Specific removal of transthyretin from plasma of patients with familial amyloidotic polyneuropathy: optimization of an immunoadsorption procedure.". (1992): http://europepmc.org/abstract/med/1316882.
    10.1177/039139889201500411
  90. Costa PP; Jacobsson B; Collins VP; Biberfeld P. "Unmasking antigen determinants in amyloid.". (1986): http://europepmc.org/abstract/med/2431032.
    10.1177/34.12.2431032
Preprint
  1. Esteban Ballestar; Ricardo Martins-Ferreira; Josep Calafell-Segura; Bárbara Leal; Javier Rodríguez-Ubreva; Elisabetta Mereu; Paulo Pinho e Costa. "The Human Microglia Atlas (HuMicA) Unravels Changes in Homeostatic and Disease-Associated Microglia Subsets across Neurodegenerative Conditions". 2023. https://doi.org/10.21203/rs.3.rs-3227213/v1.
    10.21203/rs.3.rs-3227213/v1

Other

Other output
  1. The Potential of Circulating Cell-Free DNA Methylation as an Epilepsy Biomarker. 2022. Martins-Ferreira, R; Leal, BG; Costa, PP.
    10.3389/fncel.2022.852151
  2. Long-term treatment of anemia with recombinant human erythropoietin in familial amyloidosis TTR V30M. 2008. Beirao, I; Lobato, L; Moreira, L; Costa, PM; Fonseca, I; Cabrita, A; Porto, G.
    10.1080/13506120802195840
  3. LIVER-TRANSPLANTATION FOR THE TREATMENT OF TYPE-I FAMILIAL AMYLOIDOTIC POLYNEUROPATHY. 1993. ANDREU, FRL; MUNARQUES, M; PARRILLA, P; SORIANO, JBE; COSTA, PP; COSTA, PMP; ALMEIDA, MR; et al.
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2019 - 2019 Epigenetic regulation of epilepsy-related signaling pathways in MTLE-HS and its impact on epileptogenesis
Supervisor
 Ciências Biomédicas (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2013 - 2013 Inflammation and neurotransmission in mesial temporal lobe epilepsy
Co-supervisor
 Ciências Biomédicas (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2011 - 2011 Genetic susceptibility and immune dysfunction in multiple sclerosis
Co-supervisor
 Ciências Biomédicas (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2011 - 2011 Dissecting the role of amyloid fibril deposition in the kidney in familial amyloidotic polyneuropathy.
Supervisor
 Ciências Biomédicas (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2011 - 2011 Oculopatia na polineuropatia amiloidotica familiar tipo português.
Co-supervisor
 Ciências Médicas (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2010 - 2010 Genetic characterization of the Innate Immune system of Lagomorphs (ILs, CCLs)
Co-supervisor
 Patologia e Genética Molecular (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2003 - 2003 Envolvimento Renal na Génese da Anemia na Polineuropatia Amiloidótica Familiar Tipo Português
Co-supervisor
 Ciências Médicas (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Committee member

Activity description
Role 		Institution / Organization
2010 - Current Member of the Executive Committee of the National Newborn Screening Program.
Member
 Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal