???global.info.a_carregar???
I obtained my Degree in Biochemistry (final grade: 15/20) at University of Porto (Portugal), in 2007. During that stage, I was ERASMUS student at Stockholm University (Sweden), at the laboratory headed by Prof. Elzbieta Glaser. In 2008, I completed my MSc in Biochenistry, at University of Porto, at the laboratory headed by Prof. Ana Margarida Damas, attaining a final grade of 18/20. Then, I did a PhD in Biomedical Sciences, also at University of Porto, at the laboratory headed by Dr. João H. Morais-Cabral. I completed my PhD in 2014, with the final grade "Aprovado com Distinção". During my Degree, MSc and PhD, I dedicated myself to protein structural and functional studies, resulting in five peer-reviewed research articles. Then, I moved to the University of Lisbon (Portugal), for a postdoctoral stage at the laboratories headed by Prof. Maria Carmo-Fonseca and Dr. Claus M. Azzalin, where I dedicated myself to study gene expression processes, as a critical determinant of protein cellular levels. My work has been recognized through a Travel Award to present my work at The Protein Society 31st Annual Symposium, a selected oral presentation at the 18th FEBS Young Scientists' Forum, organization of a roundtable discussion session at Cell Bio Virtual 2020: an online ASCB|EMBO meeting and an interview for the BioPhotonics magazine. In 2018, I was a visiting researcher to the laboratory headed by Prof. Alberto R. Kornblihtt, at the University of Buenos Aires (Argentina). I have been a team member in three funded projects (including MSCA RISE 734825-LysoMod) and co-supervised three graduate students. In 2021, I moved to the laboratory headed by Dr. John G. Jones, at the University of Coimbra, where I am studying the role of gut microbiota in non-alcoholic fatty liver disease.
Identification

Personal identification

Full name
João Pessoa

Citation names

  • Pessoa, JP
  • Pessoa J

Author identifiers

Ciência ID
6A13-E4C9-49E3
ORCID iD
0000-0002-9202-5728
Researcher Id
AAL-2879-2021

Email addresses

  • joao.pessoa@cnc.uc.pt (Professional)

Addresses

  • UC-Biotech, Lot 8A, Biocant Park, 3060-197, Cantanhede, Cantanhede, Portugal (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences - Molecular Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Advanced (C1) Proficiency (C2) Advanced (C1)
French Intermediate (B1) Upper intermediate (B2) Elementary (A2) Upper intermediate (B2) Elementary (A2)
Spanish; Castilian Intermediate (B1) Advanced (C1) Elementary (A2) Upper intermediate (B2) Intermediate (B1)
Education
Degree Classification
2009/12/31 - 2014/11/28
Concluded
Ciências Biomédicas (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Cyclic nucleotide regulation in a potassium channel: ligand selectivity and conformational change" (THESIS/DISSERTATION)
Aprovado com Distinção
2007/10/01 - 2008/12/23
Concluded
Bioquímica (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
"Structural and Functional Studies on Arabidopsis thaliana Transthyretin-like Protein" (THESIS/DISSERTATION)
18 valores
2003/10/01 - 2007/09/12
Concluded
Bioquímica (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"Effect of metals on the AtPreP1 peptidasome activity" (THESIS/DISSERTATION)
15 valores
Affiliation

Science

Category
Host institution
Employer
2021/09/01 - 2022/02/28 Postdoc (Research) Universidade de Coimbra, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015/01/01 - 2021/08/31 Postdoc (Research) Universidade de Lisboa Faculdade de Medicina, Portugal
Instituto de Medicina Molecular, Portugal
2018/09/04 - 2018/11/03 Visiting Researcher (Research) Universidad de Buenos Aires Facultad de Ciencias Exactas y Naturales, Argentina
Instituto de Fisiología Biología Molecular y Neurociencias, Argentina
2007/10/01 - 2014/11/30 Researcher (Research) Universidade do Porto Faculdade de Ciências, Portugal
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2007/03/01 - 2007/08/15 Research Trainee (Research) Stockholms Universitet Institutionen för biokemi och biofysik, Sweden
Projects

Grant

Designation Funders
2018 - 2021/09/30 Telomeric R-loop-mediated recombination in the alternative lengthening of telomeres pathway: towards designing novel therapeutic avenues for cancer therapy
PTDC/MED-ONC/28282/2017
Post-doc Fellow
Fundação para a Ciência e a Tecnologia
Concluded
2015 - 2021/02/28 Keeping stem cells undifferentiated: the role of a long non-coding RNA
SFRH/BPD/102323/2014
Post-doc Fellow
Fundação para a Ciência e a Tecnologia
Concluded
2016 - 2019/12/31 Making sense of antisense transcription
PTDC/BEX-BCM/5899/2014
Post-doc Fellow
Fundação para a Ciência e a Tecnologia
Concluded
2018 - 2018/11/03 LysoMod - Genetic and Small Molecule Modifiers of Lysosomal Function
734825
Post-doc Fellow
European Commission
Concluded
2009 - 2013/09/30 The molecular details of cyclic nucleotide regulation in a potassium channel
SFRH/BD/60274/2009
PhD Student Fellow
Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2021 - 2022/02 VISCERAL: The role of extrahepatic fructose metabolism in the development of non-alcoholic fatty liver disease
POCI-01-0145-FEDER-028147
Post-doc
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference poster
  1. "Compartmentalized RNA transcription in human cells". Paper presented in Cell Bio Virtual 2020: an online ASCB|EMBO meeting, 2020.
  2. "Targeting catalytically dead Cas9 to a protein-coding gene without transcriptional interference". Paper presented in EMBO Young Scientists Forum 2019 Prague, Czech Republic, 2019.
  3. "Live cell visualization of extra-chromosomal telomeric repeats in ALT cancer cells". Paper presented in 18th FEBS Young Scientists' Forum, Prague, Czech Republic, 2018.
  4. "Simultaneous visualization of a gene and its nascent transcripts in live cells". Paper presented in 31st Annual Symposium of the Protein Society Montreal, Canada, 2017.
Journal article
  1. João Pessoa. "Shifting metabolism to increase lifespan". Trends in Endocrinology & Metabolism (2022): https://doi.org/10.1016/j.tem.2022.05.001.
    10.1016/j.tem.2022.05.001
  2. Pessoa, João; Teixeira, José. "Cytoskeleton alterations in non-alcoholic fatty liver disease". Metabolism 128 (2022): 155115. http://dx.doi.org/10.1016/j.metabol.2021.155115.
    In press • 10.1016/j.metabol.2021.155115
  3. Fernández-Alvarez, Ana J.; Gabriela Thomas, María; Pascual, Malena L.; Habif, Martín; Pimentel, Jerónimo; Corbat, Agustín A.; Pessoa, João P.; et al. "Smaug1 membrane-less organelles respond to AMPK and mTOR and affect mitochondrial function". Journal of Cell Science 135 1 (2022): http://dx.doi.org/10.1242/jcs.253591.
    Published • 10.1242/jcs.253591
  4. João Pessoa. "Live-cell visualization of cytochrome c: a tool to explore apoptosis". Biochemical Society Transactions (2021): https://doi.org/10.1042/BST20211028.
    10.1042/BST20211028
  5. Pessoa, João. "Prospective antibacterial inhibition of c-type cytochrome synthesis". Trends in Molecular Medicine (2021): http://dx.doi.org/10.1016/j.molmed.2021.07.007.
    Published • 10.1016/j.molmed.2021.07.007
  6. Pessoa, João; Fonseca, Fátima; Furini, Simone; Morais-Cabral, João H.. "Determinants of ligand selectivity in a cyclic nucleotide–regulated potassium channel". The Journal of General Physiology 144 1 (2014): 41-54. http://dx.doi.org/10.1085/jgp.201311145.
    Published • 10.1085/jgp.201311145
  7. Mari, S. A.; Pessoa, J.; Altieri, S.; Hensen, U.; Thomas, L.; Morais-Cabral, J. H.; Muller, D. J.. "Gating of the MlotiK1 potassium channel involves large rearrangements of the cyclic nucleotide-binding domains". Proceedings of the National Academy of Sciences 108 51 (2011): 20802-20807. http://dx.doi.org/10.1073/pnas.1111149108.
    Published • 10.1073/pnas.1111149108
  8. Pessoa, Joao; Sarkany, Zsuzsa; Ferreira-da-Silva, Frederico; Martins, Sonia; Almeida, Maria R; Li, Jianming; Damas, Ana M. "Functional characterization of Arabidopsis thaliana transthyretin-like protein". BMC Plant Biology 10 1 (2010): 30. http://dx.doi.org/10.1186/1471-2229-10-30.
    Published • 10.1186/1471-2229-10-30
  9. Bäckman, Hans G.; Pessoa, João; Eneqvist, Therese; Glaser, Elzbieta. "Binding of divalent cations is essential for the activity of the organellar peptidasome inArabidopsis thaliana,AtPreP". FEBS Letters 583 17 (2009): 2727-2733. http://dx.doi.org/10.1016/j.febslet.2009.07.040.
    Published • 10.1016/j.febslet.2009.07.040
  10. Martins, P. M.; Pessoa, J.; Sa`rka`ny, Z.; Rocha, F.; Damas, A. M.. "Rationalizing Protein Crystallization Screenings through Water Equilibration Theory and Protein Solubility Data†". Crystal Growth & Design 8 12 (2008): 4233-4243. http://dx.doi.org/10.1021/cg8006958.
    10.1021/cg8006958
Working paper
  1. Ana J. Fernández-Alvarez; María Gabriela Thomas; Malena L. Pascual; Martín Habif; Jerónimo Pimentel; Agustín A. Corbat; Pessoa J; et al. 2020. "Smaug membraneless organelles regulate mitochondrial function". Working Paper. doi.org/10.1101/2020.07.31.223099.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2018/07/06 Live cell visualization of extra-chromosomal telomeric repeats in human ALT cancer cells FEBS Young Scientists' Forum 2018
FEBS - Federation of European Biochemical Societies (Prague, Czech Republic)
2009/02/26 A functional study of Arabidopsis thaliana transthyretin-like protein IJUP - Second Meeting of Young Researchers of U. Porto
Universidade do Porto (Porto, Portugal)
2008/02/21 Effect of metals on the AtPreP1 peptidasome activity IJUP - First Meeting of Young Researchers of U. Porto
Universidade do Porto (Porto, Portugal)

Event organisation

Event name
Type of event (Role)
Institution / Organization
2021/11/18 - 2021/11/18 Chairman at the “Science out of the box” 2nd Metabolism, Aging and Disease (MAD) Retreat (Coimbra, Portugal) (2021/11/18 - 2021/11/18)
Symposium (Member of the Scientific Committee)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/12/07 - 2020/12/07 Roundtable discussion moderator at Cell Bio Virtual 2020: an online ASCB|EMBO meeting (2020/12/07 - 2020/12/07)
Round table
2019/05/17 - 2019/05/17 Chairman at the 13th Centro Académico de Medicina de Lisboa (CAML) PhD Students Meeting, Lisboa (Portugal), an annual scientific meeting organized by and for PhD students at the Faculty of Medicine of the University of Lisbon (2019 - 2019)
Symposium (Member of the Scientific Committee)
Universidade de Lisboa Faculdade de Medicina, Portugal
2017/05/18 - 2017/05/18 Chairman at the 11th Centro Académico de Medicina de Lisboa (CAML) PhD Students Meeting, Lisboa (Portugal), an annual scientific meeting organized by and for PhD students at the Faculty of Medicine of the University of Lisbon (2017 - 2017)
Symposium (Member of the Scientific Committee)
Universidade de Lisboa Faculdade de Medicina, Portugal

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2015/06/18 Utilização do sistema CRISPR-Cas para gerar deleção do gene Ago3 em células pluripotentes
(Thesis) Main arguer
Ana Rita Teixeira Poim (Other)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2022/03/08 - Current Frontiers in Cell and Developmental Biology (ISSN 2296-634X) Frontiers Media S.A.
2021/03/15 - Current Frontiers in Oncology (2234-943X) Frontiers Media S.A.
2021/03/07 - Current European Journal of Clinical Investigation (1365-2362) John Wiley & Sons

Association member

Society Organization name Role
2018/11/01 - Current Marie Curie Alumni Association (MCAA) Member

Evaluation committee

Activity description
Role
Institution / Organization Funding entity
2022/02/26 - 2022/02/26 Juri of the 2022 Annual International Medical Students (AIMS) Meeting Research Competition poster session
Evaluator
Universidade de Lisboa Faculdade de Medicina, Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2020/12/14 3 Questions with João Pessoa https://www.photonics.com/Articles/3_Questions_with_Joo_Pessoa/p1/vo201/i1267/a66502 BioPhotonics magazine

Journal scientific committee

Journal title (ISSN) Publisher
2022/01/25 - Current Journal of Visualized Experiments (1940-087X) MyJove Corp.
2021/02/22 - Current Frontiers in Oncology (2234-943X) Frontiers Media S.A.
Distinctions

Award

2018 FEBS Young Scientists' Forum (YSF) Award
Federation of European Biochemical Societies, United Kingdom
2017 Finn Wold / Protein Science Travel Award
Protein Society, United States