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Sílvia Almeida (SA) concluiu o Doutoramento em Biologia (Imunologia Viral) em 2007 pela Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier e Licenciatura em Bioquímica em 1999 pela Faculdade de Ciências da Universidade de Lisboa. É Diretora Científica no CoLab AceelBio desde setembro de 2023, onde lidera uma equipa de cientistas dedicados à translação de projetos científicos inovadores com o objetivo de os transformar em "assets" que chegarão ao público. NA Charles River Laboratories Ireland, Ltd, SA atuou inicialmente como Virologista, passou a in vitro Scientific Manager, tendo evoluído rapidamente para a posição de Head of in vitro Scientific Development and Business Strategies. Foi Professora Visitante Estrangeira (Professora Associada) no Núcleo de Pós-Graduação em Doenças Infecciosas na Universidade Federal do Espírito Santo, Brasil (Abril 2017-Fevereiro 2019). Publicou 17 artigos em revistas especializadas. Orientou 3 dissertações de mestrado e coorientou 2. Orientou 1 trabalho(s) de conclusão de curso de licenciatura/bacharelato. Recebeu 7 prémio(s) e/ou homenagens. Participou como Bolseiro de Pós-Doutoramento em 1 projeto(s), Investigador em 3 projeto(s), Investigador Pós-doutorado em 6 projeto(s), Investigador responsável em 1 projeto(s) e Outra em 1 projeto(s). Atua nas áreas de Ciências Médicas e da Saúde com ênfase em Medicina Básica com ênfase em Imunologia, Ciências Naturais com ênfase em Ciências Biológicas com ênfase em Virologia e Ciências Naturais com ênfase em Ciências Biológicas com ênfase em Biologia Celular. No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: OprI; Adjuvant; Pattern recognition receptors; Immunomodulation; Biologia Celular e do Desenvolvimento; Imunologia; Infecção; Neurociências; Segurança Alimentar; Saúde Animal e Prevenção; Patologia e Medicina Veterinária; Biotecnologia e Produção Animal; .
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Identification

Personal identification

Full name
Sílvia Cristina de Paiva e Almeida

Citation names

  • Almeida, Sílvia

Author identifiers

Ciência ID
6919-698F-C3EF
ORCID iD
0000-0002-2400-6090

Email addresses

  • silviapalmeida@accelbio.pt (Professional)

Telephones

Mobile phone
  • 912202220 (Personal)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Immunology
  • Natural sciences - Biological Sciences - Virology
  • Natural sciences - Biological Sciences - Cell Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Spanish; Castilian Proficiency (C2) Proficiency (C2) Advanced (C1) Proficiency (C2) Proficiency (C2)
French Upper intermediate (B2) Upper intermediate (B2) Intermediate (B1) Upper intermediate (B2)
German Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2)
Russian Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2)
Education
Degree Classification
2007
Concluded
 Biologia (Doutoramento)
Major in Especialidade: Biologia
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
"Manipulation of T and B Cell Biology Through Transgenic Expression of a Vírus Gene Inhibiting Transcription Via Nf-kb and Nfat" (THESIS/DISSERTATION)
1992/09/01 - 1999/12/03
Concluded
 Bioquímica (Licenciatura)
Major in Bioquímica
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
"Identification and Characterization of Mutations in Genes Critical to Colorectal Cancer" (THESIS/DISSERTATION)
 17
Affiliation

Science

Category
Host institution 		Employer
2023/09/09 - Current Coordinating Researcher (Research) CoLab AceelBio, Portugal
CoLab AceelBio, Portugal
2011/11/01 - 2017/03/18 Postdoc (Research) Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Lisboa Instituto de Medicina Molecular, Portugal
2008/12/03 - 2011/10/31 Postdoc (Research) Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2007/11/14 - 2008/11/30 Postdoc (Research) Fundação para a Ciência e a Tecnologia, Portugal
Instituto Gulbenkian de Ciência, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2017/04/10 - 2019/02/18 Visiting Professor (University Teacher) Universidade Federal do Espírito Santo, Brazil
Universidade Federal do Espírito Santo Núcleo de Doenças Infecciosas, Brazil
2010/10/01 - 2015/07/31 Invited Assistant Professor (University Teacher) Universidade Atlântica Escola Superior de Saúde Atlântica, Portugal
Universidade Atlântica Escola Superior de Saúde Atlântica, Portugal
2008/02/01 - 2010/07/31 Invited Assistant Professor (University Teacher) Universidade Católica Portuguesa, Portugal
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal

Others

Category
Host institution 		Employer
2019/03/04 - 2023/07/29 Head of in vitro Scientific Development/Department Manager Charles River Laboratories Ireland Ltd, Ireland
Charles River Laboratories Ireland Ltd, Ireland
2001/07/01 - 2007/11/13 PhD Student Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
Instituto Gulbenkian de Ciência, Portugal
Projects

Contract

Designation Funders
2024/11/01 - 2027/10/31 A new Pathway to Modulate T cell Activity
HR24-00042
Principal investigator
Associação AccelBio, Portugal
 la Caica Foundation
Ongoing
2025/02/01 - 2026/05/31 HOP-ON: Cardiogenomics meets Artificial Intelligence: a step forward in arrhythmogenic cardiomyopathy diagnosis and treatment
101115536
Other
Comissão Europeia, Belgium
 Comissão Europeia
Ongoing
2019/01/01 - 2019/12/31 Instituto de Medicina Molecular - IMM
UID/BIM/50005/2019
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/07/01 - 2019/03/31 • Mechanisms used by T follicular helper (Tfh) cells to determine antibody isotype production in Th1 versus Th2 responses
PTDC/IMI-IMU/7038/2014
Colaborador
Universidade de Lisboa Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
2016/04/01 - 2019/03/31 Immunomodulatory Effect of CD6-targeting in Neuroinflammation
PTDC/DTP-FTO/3080/2014
Post-doc
Universidade de Lisboa Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2015/09/01 - 2018/08/31 The influence of Adjuvants on T follicular helper (Tfh) cells and B cell Isotype Switching
FCT/FAPESP project, Portugal-Brazil
Post-doc
Fundação de Amparo à Pesquisa do Estado de São Paulo
2011/11/01 - 2014/12/31 Cellular therapy for liver specific immune suppression
PTDC/SAU-TOX/114424/2009
Post-doc
Universidade de Lisboa Instituto de Medicina Molecular, Portugal
Concluded
2011/04/01 - 2014/03/31 Modulation of acquired immunity by bacterial cell wall-derived formulations containing heterologous antigens expressed by a new OprI based system
PTDC/CVT/113889/2009
Post-doc
2011/01/01 - 2013/12/31 Projecto Estratégico - UI 276 - 2011-2012
PEst-OE/AGR/UI0276/2011
Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/03/01 - 2011/10/31 Effect of the infection of swine macrophages by African swine fever virus of different virulence and the role of viral genes of unasssigned function in the regulation of mediators of immunity
PTDC/CVT/104507/2008
Post-doc
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
Concluded
2010/03/01 - 2011/10/31 Role of type II topoisomerase of the African Swine Fever virus virus in the replication of the viral DNA-a possible target for antiviral therapy
PTDC/CVT/105630/2008
Post-doc
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2008/12/01 - 2011/07/31 ASFRISK: Evaluating and controlling the risk of African swine fever in the EU
SEVENTH FRAMEWORK PROGRAMME, Grant agreement 211691
Post-doc Fellow
Conseil de l'Union Europeenne
Concluded
2005/08/01 - 2008/07/31 African Swine Fever: development of vaccines and epidemiological investigations
WT075813MA
Researcher
Instituto Gulbenkian de Ciência, Portugal
 MRC-Wellcome Trust Human Developmental Biology Resource
Concluded
2002/07/01 - 2005/06/30 Viral modulation of cell division, apoptosis and interferon responses
POCTI/MGI/45100/2002
Researcher
Fundação para a Ciência e a Tecnologia
2000/11/01 - 2003/10/31 The potential and application of virus host evasion genes that modify apoptosis and cytokines
Grant agreement QLK3-CT-2000-00362
Researcher
Conseil de l'Union Europeenne
Concluded
Outputs

Publications

Conference poster
  1. • Basto, AP, Maceiras, AR, Almeida, SCP, Campos, P, Ribeiro, F, Kumar, S, Russo, M, Graca, L. "Impact of type-1 and type-2 adjuvants on T follicular helper, T follicular regulatory and germinal center B cell populations". Paper presented in 5th European Congress of Immunology, 2018.
  2. • Kumar, S, Almeida, SCP, Campos, P, Basto, AP, Russo, M, Carvalho, M, Graca, L. "Modelling transcriptomics of T folicular helper cells across different strains of mice". Paper presented in XLIV Annual Meeting Sociedade Portuguesa de Imunologia, 2018.
  3. Basto, AP, Maceiras, AR, Almeida, SCP, Campos, P, Ribeiro, F, Kumar, S, Russo, M, Graca, L. "Characterization of T follicular helper, T follicular regulatory and germinal center B cells induced by type-1 and type-2 adjuvants". Paper presented in XLIV Annual Meeting Sociedade Portuguesa de Imunologia (SPI, 2018.
  4. • Basto, A. P., Maceiras, A. R., Almeida, S. C. P., Campos, P., Ribeiro, F., Kumar, S., Russo, M., Graca, L.. "Characterization of T follicular helper (Tfh) cells in type-1 and type-2 responses". Paper presented in iMM Scientific Retreat, 2018.
  5. Basto, AP, Maceiras, AR, Almeida, SCP, Campos, P, Ribeiro, F, Kumar, S, Russo, M, Graca, L. "Impact of type-1 and type-2 adjuvants on T follicular helper and T follicular regulatory cells and germinal center responses". Paper presented in TwinnToInfect Spring School in Infection and Immunity, 2018.
Journal article
  1. Kumar, Saumya; Basto, Afonso P.; Ribeiro, Filipa; Almeida, Silvia C. P.; Campos, Patricia; Peres, Carina; Pulvirenti, Nadia; et al. "Specialized Tfh cell subsets driving type-1 and type-2 humoral responses in lymphoid tissue". Cell Discovery 10 1 (2024): https://doi.org/10.1038/s41421-024-00681-0.
    10.1038/s41421-024-00681-0
  2. Rita Calado; Joana Duarte; Pedro Borrego; Marcelino, J.M.; Inês Bártolo; Martin F; Figueiredo I; et al. "A Prime-Boost Immunization Strategy with Vaccinia Virus Expressing Novel gp120 Envelope Glycoprotein from a CRF02_AG Isolate Elicits Cross-Clade Tier 2 HIV-1 Neutralizing Antibodies.". Vaccines (2020): https://europepmc.org/articles/PMC7349027.
    10.3390/vaccines8020171
  3. Freitas RF; Afonso Basto; Almeida SCP; Rita F Santos; Gonçalves CM; Corria-Osorio J; Carvalho T; et al. "Modulation of CD4 T cell function via CD6-targeting.". EBioMedicine (2019): https://europepmc.org/articles/PMC6796521.
    10.1016/j.ebiom.2019.08.008
  4. Maceiras AR; Almeida SCP; Mariotti-Ferrandiz E; Chaara W; Jebbawi F; Six A; Hori S; et al. "T follicular helper and T follicular regulatory cells have different TCR specificity.". Nature communications (2017): http://europepmc.org/abstract/med/28429709.
    10.1038/ncomms15067
  5. Almeida SCP; Graca L. "IL-9 Production by Nonconventional T helper Cells.". Methods in molecular biology (Clifton, N.J.) (2017): http://europepmc.org/abstract/med/28477190.
    10.1007/978-1-4939-6877-0_8
  6. Basto, Afonso P.; Badenes, Marina; Almeida, Sílvia C.P.; Martins, Carlos; Duarte, António; Santos, Dulce M.; Leitão, Alexandre. "Immune response profile elicited by the model antigen ovalbumin expressed in fusion with the bacterial OprI lipoprotein". Molecular Immunology 64 1 (2015): 36-45. https://doi.org/10.1016/j.molimm.2014.10.020.
    10.1016/j.molimm.2014.10.020
  7. Bárcia RN; Santos JM; Filipe M; Teixeira M; Martins JP; Almeida J; Água-Doce A; et al. "What Makes Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells Superior Immunomodulators When Compared to Bone Marrow Derived Mesenchymal Stromal Cells?". Stem cells international (2015): http://europepmc.org/abstract/med/26064137.
    10.1155/2015/583984
  8. Martins, J.P.; Santos, J.M.; Almeida, J.M.D.; Filipe, M.A.; De Almeida, M.V.T.; Almeida, S.C.P.; Água-Doce, A.; et al. "Towards an advanced therapy medicinal product based on mesenchymal stromal cells isolated from the umbilical cord tissue: Quality and safety data". Stem Cell Research and Therapy 5 1 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84892463335&partnerID=MN8TOARS.
    10.1186/scrt398
  9. Santos, J.M.; Bárcia, R.N.; Simões, S.I.; Gaspar, M.M.; Calado, S.; Água-Doce, A.; Almeida, S.C.P.; et al. "The role of human umbilical cord tissue-derived mesenchymal stromal cells (UCX®) in the treatment of inflammatory arthritis". Journal of Translational Medicine 11 1 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84872268288&partnerID=MN8TOARS.
    10.1186/1479-5876-11-18
  10. de Oliveira, V.L.; Almeida, S.C.P.; Soares, H.R.; Parkhouse, R.M.E.. "Selective B-cell expression of the MHV-68 latencyassociated M2 protein regulates T-dependent antibody response and inhibits apoptosis upon viral infection". Journal of General Virology 94 PART7 (2013): 1613-1623. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879186559&partnerID=MN8TOARS.
    10.1099/vir.0.050013-0
  11. Almeida, S.C.P.; de Oliveira, V.L.; Ventura, S.; Bofill, M.; Parkhouse, R.M.E.. "Neoplastic transformation of T lymphocytes through transgenic expression of a virus host modification protein". PLoS ONE 7 4 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84860494431&partnerID=MN8TOARS.
    10.1371/journal.pone.0034140
  12. de Oliveira, V.L.; Almeida, S.C.P.; Soares, H.R.; Crespo, A.; Marshall-Clarke, S.; Parkhouse, R.M.E.. "A novel TLR3 inhibitor encoded by African swine fever virus (ASFV)". Archives of Virology 156 4 (2011): 597-609. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953224771&partnerID=MN8TOARS.
    10.1007/s00705-010-0894-7
  13. Isidro G; Matos P; Almeida S; Claudino S; Marshall B; Soares J; Leite J; et al. "Eleven novel APC mutations identified in Portuguese FAP families.". Human mutation (2000): http://europepmc.org/abstract/med/10923044.
    10.1002/1098-1004(200008)16:2<178::aid-humu15>3.0.co;2-#
  14. Rebelo MJ; Almeida SC. "Hypertonic versus isotonic salt bridges and the measurement of ionized calcium.". Annals of clinical biochemistry (2000): http://europepmc.org/abstract/med/10672377.
    10.1258/0004563001901362
  15. Isidro G; Veiga I; Matos P; Almeida S; Bizarro S; Marshall B; Baptista M; et al. "Four novel MSH2 / MLH1 gene mutations in portuguese HNPCC families.". Human mutation (2000): http://europepmc.org/abstract/med/10612836.
    10.1002/(sici)1098-1004(200001)15:1<116::aid-humu24>3.0.co;2-q
  16. Rebelo, M.J.F.; Almeida, S.C.P.. "Hypertonic versus isotonic salt bridges and the measurement of ionized calcium". Annals of Clinical Biochemistry 37 1 (2000): 77-78. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033955817&partnerID=MN8TOARS.
Preprint
  1. Saumya Kumar; Afonso P. Basto; Filipa Ribeiro; Silvia C. P. Almeida; Patricia Campos; Carina Peres; Sarwah Al-Khalidi; et al. "Specialized Tfh cell subsets driving type-1 and type-2 humoral responses in lymphoid tissue". 2022. https://doi.org/10.1101/2022.07.28.501817.
    10.1101/2022.07.28.501817
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022/05/01 - 2022/09/30 Detection of Replication Competent Adeno associated virus (rcAAV) using a qPCR assay
Supervisor
 M.Sc in Cellular Manufacturing and Therapy (Master)
National University of Ireland - Galway Centre for Excellence in Learning and Teaching, Ireland
2018/03/01 - 2019/12/31 Evaluation of the impact of the ApoE genotype in response to infection by (Microbicidal activity and phenotypic profile of activation of PBMCs
Co-supervisor
 Post-Graduation Programme in Infectious Diseases (Master)
Universidade Federal do Espírito Santo Núcleo de Doenças Infecciosas, Brazil
2019/05/30 - 2019/09/30 Production of Master and Working Cell Banks of Human Cells and of Master and Working Seeds of Human
Supervisor
 M.Sc in Cellular Manufacturing and Therapy (Master)
National University of Ireland - Galway Centre for Excellence in Learning and Teaching, Ireland
2017/07/01 - 2017/12/31 Quantitave estimate of Mycobacterium tuberculosis using resazurin
Supervisor
Universidade Federal do Espírito Santo Núcleo de Doenças Infecciosas, Brazil
2015/09/01 - 2016/11/30 Characterization of T follicular helper (Tfh) cells induced by type 1 and type 2 adjuvants
Supervisor
 MSc in Biomedical Sciences (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2012/07/01 - 2013/09/30 Impact of Foxp3+ iNKT cells in allergic airways disease
Co-supervisor
 MSc in Biochemistry (Master)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2017/11/06 - 2017/11/10 1st Updating Course on Infectious Diseases: Applicability of Molecular Methods (2017/11/06 - 2017/11/10)
Symposium (Co-organisor)
 Universidade Federal do Espírito Santo Núcleo de Doenças Infecciosas, Brazil

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2020/12/14 Aspetos da infeção pelo Zika na gestação: um estudo prospetivo em coorts de gestantes e seus conceptos
(Thesis) Main arguer
 Camila Giuberti de Souza (PhD)
Universidade Federal do Espírito Santo Núcleo de Doenças Infecciosas, Brazil
2018/09/12 Expression of inhibitory receptors in T cells during infection by Leishmania braziliensis
(Thesis) Main arguer
 Juliana Bessa (Master)
Universidade Federal do Espírito Santo Núcleo de Doenças Infecciosas, Brazil
2015/10 Expression and Regulation of Human Endogenous Retroviruses (HERVs) in developing and mature T Cells
(Thesis) Main arguer
 VÂNIA PATRÍCIA MENDES PASSOS (Master)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2017/07/13 - Current HIV: molecular biology of infection and Anti-Retroviral Therapy, 1 hour, 13th July 2017 (Postgraduate Certificate) Universidade Federal do Espírito Santo Núcleo de Doenças Infecciosas, Brazil
2024/04/17 - 2024/04/17 Quality standards and best practices (QSBP) in laboratory techniques: Challenges and implementation in academia, an AccelBio Series Workshop (online), April 17th 2024. Workshop (Outros) Associação AccelBio, Portugal
2017/11/06 - 2017/11/10 Talk 1 - Molecular techniques and its applications: Southern, Northern and Western Blot Talk 2 - Epigenetics, Microarray, FISH and Aplicability of Molecular Biology in Diagnostics of Infectious Diseases 1st Updating Course on Infectious Diseases: Applicability of Molecular Methods (Postgraduate Certificate) Universidade Federal do Espírito Santo Núcleo de Doenças Infecciosas, Brazil

Other jury / evaluation

Activity description Institution / Organization
2024/06/05 - 2024/06/05 Evaluator at the Venture Capital Program, Pitch Presentations To Companies (https://epiepinet.imm.medicina.ulisboa.pt/epic2024/#about-the-program), EpiC2024 Epileptogenesis and Epilepsy Network Meeting, Instituto Gulbenkian de Medicina Molecular, June 03rd-05th, 2024 (https://epiepinet.imm.medicina.ulisboa.pt/epic2024/#epic2024). Gulbenkian Institute for Molecular Medicine, Portugal
2017/08/01 - 2019/02/28 Associate Editor, Brazilian Journal of Health Research Brazilian Journal of Health Research, Brazil
2017/04/10 - 2019/02/18 Thesis Committee Examiner for PhD Qualification Universidade Federal do Espírito Santo Núcleo de Doenças Infecciosas, Brazil
2017/04/10 - 2019/02/18 Thesis Commitee Examiner for MSc Qualification Universidade Federal do Espírito Santo Núcleo de Doenças Infecciosas, Brazil
Distinctions

Other distinction

2011 Bolsa de pos-doutoramento
Fundação para a Ciência e a Tecnologia, Portugal
2008 Bolsa de pos-doutoramento
European Molecular Biology Laboratory, Germany
2008 Bolsa de pos-doutoramento
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2007 Bolsa de pos-doutoramento
National Institute for Health Research Wellcome Trust Imperial Clinical Research Facility, United Kingdom
2004 Bolsa de Assistente de Investigação
National Institute for Health Research Wellcome Trust Imperial Clinical Research Facility, United Kingdom
2000 Bolsa de Doutoramento
Fundação para a Ciência e a Tecnologia, Portugal
1999 Bolsa PRODEP de Mérito
Republica Portuguesa Ministério da Educação, Portugal