???global.info.a_carregar???
Manuel Vilanova currently is Full Professor of Immunology and Vice-Dean at ICBAS - School of Medicine and Biomedical Sciences of Universidade do Porto. At ICBAS MV coordinates curricular units in the fields of immunology and infection and currently directs the PhD programme on Molecular and Cellular Biotechnology Applied to Health Sciences (BiotechHealth). MV graduated in Biochemistry by U.Porto in 1988 and joined the Laboratory of Immunology at ICBAS in 1989, working under the supervision of Prof. Mário Arala Chaves. MV defended the PhD thesis in Biomedical Sciences at ICBAS in 1999. He was PI in 5 funded projects and participated as co-PI/team member in > 20 other funded projects, mainly in the areas of immunology and infection. MV supervised/co-supervised circa 30 PhD students, and 5 post-docs. He authored/co-authored > 120 research articles published in international peer-reviewed journals, and book chapters and patents, mainly in the fields of immunology, infection and microbiology. His studies particularly addressed immunobiological mechanisms operating in hosts infected with patogens with high impact in human or animal health, such as Staphylococcus epidermidis, Candida albicans, and Neospora caninum. He is/was Editorial Board member in international scientific journals, including "Carbohydrate Polymers" and "Scientific Reports". Manuel Vilanova directs since 2005 the Immunobiology group of Instituto de Biologia Molecular e Celular (IBMC) at Porto, now integrating the Instituto de Inovação e Investigação em Saúde (I3S) of U.Porto. He presided the Portuguese Society for Immunology in 2012-2015.
Read full resume ↓
Identification

Personal identification

Full name
Manuel Vilanova

Author identifiers

Ciência ID
681E-3435-C7F8
ORCID iD
0000-0001-7007-306X
Researcher Id
D-2127-2013
Scopus Author Id
7004113667

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Immunology
Education
Degree Classification
1999/06/25
Concluded
 Doutoramento em Ciências Biomédicas (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1983 - 1988
Concluded
 Biochemistry (Licenciatura)
Universidade do Porto, Portugal
Affiliation

Science

Category
Host institution 		Employer
2015 - Current Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2023/01/16 - Current Full Professor (University Teacher) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Projects

Contract

Designation Funders
2022/01/01 - 2024/12/31 Combined mucosal and systemic immunization to protect against bovine neosporosis
PTDC/CVT-CVT/3045/2021
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2020/10/01 - 2023/09/30 HEALTH-UNORTE: Setting-up biobanks and regenerative medicine strategies to boost research in cardiovascular, musculoskeletal, neurological, oncological, immunological and infectious diseases
NORTE-01-0145-FEDER-000039
Responsible Investigator at ICBAS
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Concluded
2022/01/01 - 2023/06/30 Meningeal Immunity and NeuroInflammation: deciphering the immune cells intervening in neonatal bacterial meningitis
EXPL/SAU-INF/1217/2021
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2021/01/01 - 2023/06/30 MARemPó
POCI-01-0247-FEDER-047200
ALG-01-0247-FEDER-047200
Researcher
Concluded
2021/01/01 - 2023/06/30 BUGS@PETS - Development of new insect ingredients for incorporation into complete compound foods for pets
POCI-01-0247-FEDER-047042
Researcher
Concluded
2019/01/01 - 2022/12/31 ALGAVALOR – MicroALGAs: produção integrada e VALORização da biomassa e das suas diversas aplicações
POCI-01-0247-FEDER-035234
LISBOA-01-0247-FEDER-035234
ALG-01-0247-FEDER-035234
Researcher
Concluded
2018/09/01 - 2021/08/31 Valuation of brewers spent yeast polysaccharides for food and biomedical applications
PTDC/BAA-AGR/30936/2017
Researcher
Universidade de Aveiro, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/07/26 - 2021/07/25 Dietary polyphenols as prophylactic agents in food allergies
PTDC/SAU-NUT/30448/2017
Researcher
Universidade do Porto Faculdade de Ciências, Portugal
Concluded
2018/07/01 - 2021/06/30 Impact of S. epidermidis dormancy and persistence in host pathogenesis
PTDC/BIA-MOL/29553/2017
Principal investigator
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/07/01 - 2021/06/30 Dietary Polyphenol's Role in the Prevention of Celiac Disease
PTDC/OCE-ETA/32287/2017
Researcher
Universidade do Porto Faculdade de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/06/01 - 2021/05/31 Development of an experimental vaccine against neosporosis in cattle
PTDC/CVT-CVT/31020/2017
Researcher
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/06/01 - 2021/05/31 Glycans in autoimmunity. Impact in Systemic Lupus Erythematosus pathogenesis and treatment.
PTDC/MEC-REU/28772/2017
Researcher
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2016/12/01 - 2019/12/01 MinDog - organic minerals in dog feeding
POCI-01-0247-FEDER-017616
Researcher
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
 Agência Nacional de Inovação SA
Concluded
2016/07/01 - 2019/07/01 Glycans as novel immunomodulators in Inflammatory Bowel Disease: an opportunity for new therapeutic strategies.
PTDC/DTP-PIC/0560/2014
Researcher
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2016/07/01 - 2019/06/30 Study of the immune function of adipose tissue in Neospora caninum infected hosts.
PTDC/CVT-WEL/3079/2014
POCI-01-0145-FEDER-016732
POCI-01-0145-FEDER-016732
Researcher
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
 Fundação para a Ciência e a Tecnologia

European Regional Development Fund
Concluded
2016/05/01 - 2019/04/30 Structured program on bioengineered therapies for infectious diseases and tissue regeneration.
Norte-01-0145-FEDER-000012.
Researcher
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 European Regional Development Fund
Concluded
2014/03/01 - 2015/08/01 Transcriptomic analysis of biofilm-released Staphylococcus epidermidis cells response to human blood components.
EXPL/BIA-MIC/0101/2013
Researcher
Fundação para a Ciência e a Tecnologia

European Regional Development Fund
Concluded
2014/01/01 - 2015/06/16 Seaweeds in Ruminant Feeding
EXPL/CVT-NUT/0286/2013
Researcher
European Regional Development Fund

Fundação para a Ciência e a Tecnologia
Concluded
2013/12/01 - 2014/12/01 T cell receptor N-glycosylation as a new mechanism underlying Inflammatory Bowel Disease pathogenesis. Implications for therapy
EXPL/BIM-MEC/0149/2012
Researcher
Fundação para a Ciência e a Tecnologia

European Regional Development Fund
Concluded
2011/01/01 - 2013/12/31 Molecular interactions between S. epidermidis biofilm cells and the murine host response
PTDC/BIAMIC/113450/2009
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2013/09/01 Study of the immune response and protective effect against neosporosis elicited by mucosal immunization with Neospora caninum antigens.
PTDC/CVT/115126/2009
Principal investigator
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2009/03/04 - 2011/12/31 IMMUNONET-Network on immunotherapy
SUDOE-FEDERIMMUNONETSOE1/P1/E014
Principal investigator
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Concluded
2005/06/01 - 2008/05/31 Immunobiological studies of secreted aspartic proteases secreted by Candida albicans and their usage as target antigens against systemic candidiasis.
POCTI/SAU/IMI/58014/2004
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2002/11/02 - 2006/09/01 Immunobiological studies in murine models of Neospora caninum infection towards the development of new vaccination approaches
info:eu-repo/grantAgreement/FCT/POCI/38795/PT
Principal investigator
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
 Fundação para a Ciência e a Tecnologia

European Regional Development Fund
Concluded
2001/04/01 - 2005/08/15 Immunobiological studies of microbial virulence immunomodulatory proteins that allow the survival of the secreting microorganism in the host.
POCTI/MGI/33570/99
Principal investigator
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
 Fundação para a Ciência e a Tecnologia

European Regional Development Fund
Concluded
Outputs

Publications

Book chapter
  1. Almeida, Maria Strecht; Bertolami, Orfeu; Vilanova, Manuel. "Culturas na Produção de Conhecimento em Ciência – análise de uma experiência multidisciplinar no contexto de formação graduada". In Unidades Curriculares INOVPED da Universidade do Porto: Transversalidade e Criatividade, Cadernos de Inovação Pedagógica, 37-51. U.Porto Press, 2022.
    Published
  2. Almeida, Maria Strecht; Vilanova, Manuel. "Vacinação, sustentabilidade e a ideia de Uma Só Saúde". In A Sustentabilidade Como Princípio Ético, a Visão de Diferentes Perspetivas, 71-85. U.Porto Press, 2022.
    Published
Journal article
  1. Cabrita, Ana R. J.; Barroso, Carolina; Fontes-Sousa, Ana Patrícia; Correia, Alexandra; Teixeira, Luzia; Maia, Margarida R. G.; Vilanova, Manuel; et al. "Assessing functional properties of diet protein hydrolysate and oil from fish waste on canine immune parameters, cardiac biomarkers, and fecal microbiota". Frontiers in Veterinary Science 11 (2024): https://doi.org/10.3389/fvets.2024.1449141.
    10.3389/fvets.2024.1449141
  2. Lopes, Nathalie; Pereira, Renato B.; Correia, Alexandra; Vilanova, Manuel; Cerca, Nuno; França, Angela. "Deletion of codY impairs Staphylococcus epidermidis biofilm formation, generation of viable but non-culturable cells and stimulates cytokine production in human macrophages". Journal of Medical Microbiology 73 5 (2024): https://doi.org/10.1099/jmm.0.001837.
    10.1099/jmm.0.001837
  3. Oliveira, Bárbara M.; Sidónio, Beatriz; Correia, Alexandra; Pinto, Ana; Azevedo, Maria M.; Sampaio, Paula; Ferreira, Paula G.; Vilanova, Manuel; Teixeira, Luzia. "Cytokine production by bovine adipose tissue stromal vascular fraction cells upon Neospora caninum stimulation". Scientific Reports 14 1 (2024): http://dx.doi.org/10.1038/s41598-024-58885-z.
    10.1038/s41598-024-58885-z
  4. Rui M. Gil da Costa; Christine Levesque; Daniella Bianchi-Frias; Payel Chatterjee; Hung-Ming Lam; Carlos Santos; Ilsa M. Coleman; et al. "Pharmacological NF-¿B inhibition decreases cisplatin chemoresistance in muscle-invasive bladder cancer and reduces cisplatin-induced toxicities.". Molecular Oncology (2023): https://doi.org/10.1002/1878-0261.13504.
    10.1002/1878-0261.13504
  5. Costa-Barbosa, Augusto; Pacheco, Maria Inês; Carneiro, Catarina; Botelho, Cláudia; Gomes, Andreia C.; Real Oliveira, M. Elisabete C.D.; Collins, Tony; et al. "Design of a lipid nano-delivery system containing recombinant Candida albicans chitinase 3 as a potential vaccine against fungal infections". Biomedicine & Pharmacotherapy 166 (2023): 115362. http://dx.doi.org/10.1016/j.biopha.2023.115362.
    10.1016/j.biopha.2023.115362
  6. Iris Caramalho; Maria Strecht Almeida; Manuel Vilanova; Carlos Penha-Gonçalves. "Portuguese Society of Immunology (SPI): Turning 50, inspired by the past, looking into the future". European Journal of Immunology (2023): https://doi.org/10.1002/eji.202350570.
    10.1002/eji.202350570
  7. Vicente, Manuel M.; Alves, Inês; Fernandes, Ângela; Dias, Ana M.; Santos-Pereira, Beatriz; Pérez-Anton, Elena; Santos, Sofia; et al. "Mannosylated glycans impair normal T-cell development by reprogramming commitment and repertoire diversity". Cellular & Molecular Immunology 20 8 (2023): 955-968. http://dx.doi.org/10.1038/s41423-023-01052-7.
    10.1038/s41423-023-01052-7
  8. Moreira, Ana S. P.; Gaspar, Diana; Ferreira, Sónia S.; Correia, Alexandra; Vilanova, Manuel; Perrineau, Marie-Mathilde; Kerrison, Philip D.; et al. "Water-Soluble Saccharina latissima Polysaccharides and Relation of Their Structural Characteristics with In Vitro Immunostimulatory and Hypocholesterolemic Activities". Marine Drugs 21 3 (2023): 183. http://dx.doi.org/10.3390/md21030183.
    10.3390/md21030183
  9. Sónia S. Ferreira; Alexandra Correia; Artur M.S. Silva; Dulcineia Ferreira Wessel; Susana M. Cardoso; Manuel Vilanova; Manuel A. Coimbra. "Structure-function relationships of pectic polysaccharides from broccoli by-products with in vitro B lymphocyte stimulatory activity". Carbohydrate Polymers 303 (2023): 120432-120432. http://dx.doi.org/10.1016/j.carbpol.2022.120432.
    10.1016/j.carbpol.2022.120432
  10. Reis, Sofia F.; Martins, Vitor J.; Bastos, Rita; Lima, Tânia; Correia, Viviana G.; Pinheiro, Benedita A.; Silva, Lisete M.; et al. "Feasibility of Brewer’s Spent Yeast Microcapsules as Targeted Oral Carriers". Foods 12 2 (2023): 246. http://dx.doi.org/10.3390/foods12020246.
    10.3390/foods12020246
  11. Ferreira, Catarina M.; Micheli, Consuelo; Barreira-Silva, Palmira; Barbosa, Ana Margarida; Resende, Mariana; Vilanova, Manuel; Silvestre, Ricardo; et al. "IL-10 Overexpression After BCG Vaccination Does Not Impair Control of Mycobacterium tuberculosis Infection". Frontiers in Immunology 13 (2022): http://dx.doi.org/10.3389/fimmu.2022.946181.
    10.3389/fimmu.2022.946181
  12. Tânia Lima; Stefán B. Gunnarsson; Elisabete Coelho; Dmitry V. Evtuguin; Alexandra Correia; Manuel A. Coimbra; Tommy Cedervall; Manuel Vilanova. "ß-Glucan-Functionalized Nanoparticles Down-Modulate the Proinflammatory Response of Mononuclear Phagocytes Challenged with Candida albicans". Nanomaterials (2022): https://doi.org/10.3390/nano12142475.
    10.3390/nano12142475
  13. Alexandra Correia; Pedro Alves; Ricardo Fróis-Martins; Luzia Teixeira; Manuel Vilanova. "Protective Effect against Neosporosis Induced by Intranasal Immunization with Neospora caninum Membrane Antigens Plus Carbomer-Based Adjuvant". Vaccines (2022): https://doi.org/10.3390/vaccines10060925.
    10.3390/vaccines10060925
  14. Hamed, Mariem; Coelho, Elisabete; Bastos, Rita; Evtuguin, Dmitry V.; Ferreira, Sónia S.; Lima, Tânia; Vilanova, Manuel; et al. "Isolation and identification of an arabinogalactan extracted from pistachio external hull: Assessment of immunostimulatory activity". Food Chemistry 373 (2022): 131416. http://dx.doi.org/10.1016/j.foodchem.2021.131416.
    10.1016/j.foodchem.2021.131416
  15. Fernando Oliveira; Tânia Lima; Alexandra Correia; Ana Margarida Silva; Cristina Soares; Simone Morais; Samira Weißelberg; et al. "Involvement of the Iron-Regulated Loci hts and fhuC in Biofilm Formation and Survival of Staphylococcus epidermidis within the Host". Microbiology Spectrum (2022): https://doi.org/10.1128/spectrum.02168-21.
    10.1128/spectrum.02168-21
  16. Gaio, Vania; Lima, Tania; Vilanova, Manuel; Cerca, Nuno; Franca, Angela. "mazEF Homologue Has a Minor Role in Staphylococcus epidermidis 1457 Virulence Potential". Frontiers in Cellular and Infection Microbiology (2022): https://publons.com/wos-op/publon/51192681/.
    10.3389/FCIMB.2021.803134
  17. Oliveira, Fernando; Lima, Tânia; Correia, Alexandra; Silva, Ana Margarida; Soares, Cristina; Morais, Simone; Weißelberg, Samira; et al. "Siderophore-Mediated Iron Acquisition Plays a Critical Role in Biofilm Formation and Survival of Staphylococcus epidermidis Within the Host". Frontiers in Medicine 8 (2021): http://dx.doi.org/10.3389/fmed.2021.799227.
    10.3389/fmed.2021.799227
  18. Oliveira, Fernando; Rohde, Holger; Vilanova, Manuel; Cerca, Nuno. "Fighting Staphylococcus epidermidis Biofilm-Associated Infections: Can Iron Be the Key to Success?". Frontiers in Cellular and Infection Microbiology 11 (2021): http://dx.doi.org/10.3389/fcimb.2021.798563.
    10.3389/fcimb.2021.798563
  19. Oliveira, Fernando; Rohde, Holger; Vilanova, Manuel; Cerca, Nuno. "The Emerging Role of Iron Acquisition in Biofilm-Associated Infections". Trends in Microbiology (2021): http://dx.doi.org/10.1016/j.tim.2021.02.009.
    10.1016/j.tim.2021.02.009
  20. Barros, Mariana; Teixeira, Daniela; Vilanova, Manuel; Correia, Alexandra; Teixeira, Natercia; Borges, Margarida. "Vaccines in Congenital Toxoplasmosis: Advances and Perspectives". Frontiers in Immunology 11 (2021): http://dx.doi.org/10.3389/fimmu.2020.621997.
    Open access • Published • 10.3389/fimmu.2020.621997
  21. Ferreira, Andreia S.; Mendonca, Ines; Povoa, Ines; Carvalho, Helia; Correia, Alexandra; Vilanova, Manuel; Silva, Tiago H.; Coimbra, Manuel A.; Nunes, Claudia. "Impact of growth medium salinity on galactoxylan exopolysaccharides of Porphyridium purpureum". Algal Research (2021): https://publons.com/wos-op/publon/49537052/.
    10.1016/J.ALGAL.2021.102439
  22. Pedro, Ana R. V.; Lima, Tania; Frois-Martins, Ricardo; Leal, Barbara; Ramos, Isabel C.; Martins, Elisabete G.; Cabrita, Ana R. J.; et al. "Dectin-1-Mediated Production of Pro-Inflammatory Cytokines Induced by Yeast beta-Glucans in Bovine Monocytes". Frontiers in Immunology (2021): https://publons.com/wos-op/publon/46883768/.
    10.3389/FIMMU.2021.689879
  23. Silva, Mariana C.; Fernandes, Ângela; Oliveira, Maria; Resende, Carlos; Correia, Alexandra; de-Freitas-Junior, Julio C.; Lavelle, Aonghus; et al. "Glycans as Immune Checkpoints: Removal of Branched N-glycans Enhances Immune Recognition Preventing Cancer Progression". Cancer Immunology Research 8 11 (2020): 1407-1425. http://dx.doi.org/10.1158/2326-6066.cir-20-0264.
    10.1158/2326-6066.cir-20-0264
  24. Teixeira, Luzia; Correia, Alexandra; Oliveira, Bárbara M.; Pinto, Ana; Ferreira, Paula G.; Vilanova, Manuel. "Modulation of Leptin and Leptin Receptor Expression in Mice Acutely Infected with Neospora caninum". Pathogens 9 7 (2020): 587. http://dx.doi.org/10.3390/pathogens9070587.
    10.3390/pathogens9070587
  25. Pereira, Ana Margarida; Guedes, Margarida; Matos, Elisabete; Pinto, Edgar; Almeida, Agostinho A.; Segundo, Marcela A.; Correia, Alexandra; et al. "Effect of Zinc Source and Exogenous Enzymes Supplementation on Zinc Status in Dogs Fed High Phytate Diets". Animals 10 3 (2020): 400. http://dx.doi.org/10.3390/ani10030400.
    10.3390/ani10030400
  26. Cabral, Maria P.; Correia, Alexandra; Vilanova, Manuel; Gärtner, Fátima; Moscoso, Miriam; García, Patricia; Vallejo, Juan A.; et al. "A live auxotrophic vaccine confers mucosal immunity and protection against lethal pneumonia caused by Pseudomonas aeruginosa". PLOS Pathogens 16 2 (2020): e1008311. http://dx.doi.org/10.1371/journal.ppat.1008311.
    10.1371/journal.ppat.1008311
  27. Oliveira, Bárbara M.; Pinto, Ana; Correia, Alexandra; Ferreira, Paula G.; Vilanova, Manuel; Teixeira, Luzia. "Characterization of Myeloid Cellular Populations in Mesenteric and Subcutaneous Adipose Tissue of Holstein-Friesian Cows". Scientific Reports 10 1 (2020): http://dx.doi.org/10.1038/s41598-020-58678-0.
    10.1038/s41598-020-58678-0
  28. Lima, Tânia; Bernfur, Katja; Vilanova, Manuel; Cedervall, Tommy. "Understanding the Lipid and Protein Corona Formation on Different Sized Polymeric Nanoparticles". Scientific Reports 10 1 (2020): http://dx.doi.org/10.1038/s41598-020-57943-6.
    10.1038/s41598-020-57943-6
  29. Ferreira, Andreia S.; Ferreira, Sónia S.; Correia, Alexandra; Vilanova, Manuel; Silva, Tiago H.; Coimbra, Manuel A.; Nunes, Cláudia. "Reserve, structural and extracellular polysaccharides of Chlorella vulgaris: A holistic approach". Algal Research 45 (2020): 101757. http://dx.doi.org/10.1016/j.algal.2019.101757.
    10.1016/j.algal.2019.101757
  30. Pandeirada, Carolina O.; Maricato, Élia; Ferreira, Sónia S.; Correia, Viviana G.; Pinheiro, Benedita A.; Evtuguin, Dmitry V.; Palma, Angelina S.; et al. "Structural analysis and potential immunostimulatory activity of Nannochloropsis oculata polysaccharides". Carbohydrate Polymers 222 (2019): 114962. http://dx.doi.org/10.1016/j.carbpol.2019.06.001.
    10.1016/j.carbpol.2019.06.001
  31. Nunes, Cláudia; Rocha, Ana; Quitério, Pedro; Ferreira, Sónia S.; Correia, Alexandra; Vilanova, Manuel; Coimbra, Manuel A.. "Salt pan brine water as a sustainable source of sulphated polysaccharides with immunostimulatory activity". International Journal of Biological Macromolecules 133 (2019): 235-242. http://dx.doi.org/10.1016/j.ijbiomac.2019.04.021.
    10.1016/j.ijbiomac.2019.04.021
  32. Oliveira, Bárbara M.; Rasteiro, Ana M.; Correia, Alexandra; Pinto, Ana; Meireles, Pedro; Ferreira, Paula G.; Vilanova, Manuel; Teixeira, Luzia. "T cells in mesenteric and subcutaneous adipose tissue of Holstein-Friesian cows". Scientific Reports 9 1 (2019): http://dx.doi.org/10.1038/s41598-019-39938-0.
    10.1038/s41598-019-39938-0
  33. Rodrigues, Célia; Correia, Alexandra; Vilanova, Manuel; Henriques, Mariana. "Inflammatory Cell Recruitment in Candida glabrata Biofilm Cell-Infected Mice Receiving Antifungal Chemotherapy". Journal of Clinical Medicine 8 2 (2019): 142. http://dx.doi.org/10.3390/jcm8020142.
    10.3390/jcm8020142
  34. Silva-Carvalho, Ricardo; Silva, João P.; Ferreirinha, Pedro; Leitão, Alexandre F.; Andrade, Fábia K.; da Costa, Rui M. Gil; Cristelo, Cecília; et al. "Inhalation of Bacterial Cellulose Nanofibrils Triggers an Inflammatory Response and Changes Lung Tissue Morphology of Mice". Toxicological Research 35 1 (2019): 45-63. http://dx.doi.org/10.5487/tr.2019.35.1.045.
    10.5487/tr.2019.35.1.045
  35. Correia, Ana; Silva, Dany; Correia, Alexandra; Vilanova, Manuel; Gärtner, Fátima; Vale, Nuno. "Study of New Therapeutic Strategies to Combat Breast Cancer Using Drug Combinations". Biomolecules 8 4 (2018): 175. http://dx.doi.org/10.3390/biom8040175.
    10.3390/biom8040175
  36. Ferreirinha, Pedro; Fróis-Martins, Ricardo; Teixeira, Luzia; Rocha, António; Vilanova, Manuel; Correia, Alexandra. "Interferon-¿-dependent protection against Neospora caninum infection conferred by mucosal immunization in IL-12/IL-23 p40-deficient mice". Vaccine 36 32 (2018): 4890-4896. http://dx.doi.org/10.1016/j.vaccine.2018.06.060.
    10.1016/j.vaccine.2018.06.060
  37. Furtado, José M.; Almeida, Sílvia M.; Mascarenhas, Paulo; Ferraz, Maria E.; Ferreira, José C.; Vilanova, Manuel; Monteiro, Mariana P.; Ferraz, Fernando P.. "Anthropometric features as predictors of atherogenic dyslipidemia and cardiovascular risk in a large population of school-aged children". PLOS ONE 13 6 (2018): e0197922. http://dx.doi.org/10.1371/journal.pone.0197922.
    10.1371/journal.pone.0197922
  38. Dias, Ana M.; Correia, Alexandra; Pereira, Márcia S.; Almeida, Catarina R.; Alves, Inês; Pinto, Vanda; Catarino, Telmo A.; et al. "Metabolic control of T cell immune response through glycans in inflammatory bowel disease". Proceedings of the National Academy of Sciences 115 20 (2018): E4651-E4660. http://dx.doi.org/10.1073/pnas.1720409115.
    10.1073/pnas.1720409115
  39. Almeida, Sílvia M.; Furtado, José M.; Mascarenhas, Paulo; Ferraz, Maria E.; Ferreira, José C.; Monteiro, Mariana P.; Vilanova, Manuel; Ferraz, Fernando P.. "Association between LEPR, FTO, MC4R, and PPARG-2 polymorphisms with obesity traits and metabolic phenotypes in school-aged children". Endocrine 60 3 (2018): 466-478. http://dx.doi.org/10.1007/s12020-018-1587-3.
    10.1007/s12020-018-1587-3
  40. Freitas, Ana I; Lopes, Nathalie; Oliveira, Fernando; Brás, Susana; França, Ângela; Vasconcelos, Carlos; Vilanova, Manuel; Cerca, Nuno. "Comparative analysis between biofilm formation and gene expression in Staphylococcus epidermidis isolates". Future Microbiology 13 4 (2018): 415-427. http://dx.doi.org/10.2217/fmb-2017-0140.
    10.2217/fmb-2017-0140
  41. Ferreira, Sónia S.; Passos, Cláudia P.; Cepeda, Márcio R.; Lopes, Guido R.; Teixeira-Coelho, Maria; Madureira, Pedro; Nunes, Fernando M.; Vilanova, Manuel; Coimbra, Manuel A.. "Structural polymeric features that contribute to in vitro immunostimulatory activity of instant coffee". Food Chemistry 242 (2018): 548-554. http://dx.doi.org/10.1016/j.foodchem.2017.09.059.
    10.1016/j.foodchem.2017.09.059
  42. Sanfins, Elodie; Correia, Alexandra; B. Gunnarsson, Stefan; Vilanova, Manuel; Cedervall, Tommy. "Nanoparticle effect on neutrophil produced myeloperoxidase". PLOS ONE 13 1 (2018): e0191445. http://dx.doi.org/10.1371/journal.pone.0191445.
    10.1371/journal.pone.0191445
  43. Carvalhais, Virginia; Pérez-Cabezas, Begoña; Oliveira, Cátia; Vitorino, Rui; Vilanova, Manuel; Cerca, Nuno. "Tetracycline and rifampicin induced a viable but nonculturable state in Staphylococcus epidermidis biofilms". Future Microbiology 13 1 (2018): 27-36. http://dx.doi.org/10.2217/fmb-2017-0107.
    10.2217/fmb-2017-0107
  44. Hinzmann, M.; Lopes-Lima, M.; Cerca, F.; Correia, A.; Machado, J.; Vilanova, M.. "Identification of distinct haemocyte populations from the freshwater bivalves swan mussel (Anodonta cygnea) and duck mussel (Anodonta anatina) using wheat-germ agglutinin". Canadian Journal of Zoology 95 12 (2017): 937-947. http://dx.doi.org/10.1139/cjz-2017-0006.
    10.1139/cjz-2017-0006
  45. Santos, Carlos; Vilanova, Manuel; Medeiros, Rui; Gil da Costa, Rui M.. "HPV-transgenic mouse models: Tools for studying the cancer-associated immune response". Virus Research 235 (2017): 49-57. http://dx.doi.org/10.1016/j.virusres.2017.04.001.
    10.1016/j.virusres.2017.04.001
  46. Ferreirinha, Pedro; Correia, Alexandra; Teixeira-Coelho, Maria; Osório, Hugo; Teixeira, Luzia; Rocha, António; Vilanova, Manuel. "Mucosal immunization confers long-term protection against intragastrically established Neospora caninum infection". Vaccine 34 50 (2016): 6250-6258. http://dx.doi.org/10.1016/j.vaccine.2016.10.056.
    10.1016/j.vaccine.2016.10.056
  47. Cabrita, Ana R. J.; Correia, Alexandra; Rodrigues, Ana R.; Cortez, Paulo P.; Vilanova, Manuel; Fonseca, António J.M.. "Assessing in vivo digestibility and effects on immune system of sheep fed alfalfa hay supplemented with a fixed amount of Ulva rigida and Gracilaria vermiculophylla". Journal of Applied Phycology 29 2 (2016): 1057-1067. http://dx.doi.org/10.1007/s10811-016-0999-9.
    10.1007/s10811-016-0999-9
  48. Santos, Sofia N.; Junqueira, Mara S.; Francisco, Guilherme; Vilanova, Manuel; Magalhães, Ana; Baruffi, Marcelo Dias; Chammas, Roger; et al. "O-glycan sialylation alters galectin-3 subcellular localization and decreases chemotherapy sensitivity in gastric cancer". Oncotarget 7 50 (2016): http://dx.doi.org/10.18632/oncotarget.13192.
    10.18632/oncotarget.13192
  49. Santos, Carlos; Ferreirinha, Pedro; Sousa, Hugo; Ribeiro, Joana; Bastos, Margarida M.S.M.; Neto, Tiago; Oliveira, Paula A.; et al. "Ptaquiloside from bracken (Pteridium spp.) inhibits tumour-infiltrating CD8+ T cells in HPV-16 transgenic mice". Food and Chemical Toxicology 97 (2016): 277-285. http://dx.doi.org/10.1016/j.fct.2016.09.019.
    10.1016/j.fct.2016.09.019
  50. França, Angela; Pérez-Cabezas, Begoña; Correia, Alexandra; Pier, Gerald B.; Cerca, Nuno; Vilanova, Manuel. "Staphylococcus epidermidis Biofilm-Released Cells Induce a Prompt and More Marked In vivo Inflammatory-Type Response than Planktonic or Biofilm Cells". Frontiers in Microbiology 7 (2016): http://dx.doi.org/10.3389/fmicb.2016.01530.
    10.3389/fmicb.2016.01530
  51. Ferreirinha, Pedro; Pérez-Cabezas, Begoña; Correia, Alexandra; Miyazawa, Bruna; França, Angela; Carvalhais, Virgínia; Faustino, Augusto; et al. "Poly-N-Acetylglucosamine Production by Staphylococcus epidermidis Cells Increases TheirIn VivoProinflammatory Effect". Infection and Immunity 84 10 (2016): 2933-2943. http://dx.doi.org/10.1128/iai.00290-16.
    10.1128/iai.00290-16
  52. Gonçalves, Catarina; Ferreira, Sílvia A; Correia, Alexandra L; Lopes, Célia; Fleming, Carolina E; Rocha, Eduardo; Vilanova, Manuel; Gama, Miguel. "Potential of mannan or dextrin nanogels as vaccine carrier/adjuvant systems". Journal of Bioactive and Compatible Polymers 31 5 (2016): 453-466. http://dx.doi.org/10.1177/0883911516631354.
    10.1177/0883911516631354
  53. França, Angela; Pier, Gerald B.; Vilanova, Manuel; Cerca, Nuno. "Transcriptomic Analysis of Staphylococcus epidermidis Biofilm-Released Cells upon Interaction with Human Blood Circulating Immune Cells and Soluble Factors". Frontiers in Microbiology 7 (2016): http://dx.doi.org/10.3389/fmicb.2016.01143.
    10.3389/fmicb.2016.01143
  54. Carneiro, Catarina; Correia, Alexandra; Lima, Tânia; Vilanova, Manuel; Pais, Célia; Gomes, Andreia C.; Real Oliveira, M. Elisabete C.D.; Sampaio, Paula. "Protective effect of antigen delivery using monoolein-based liposomes in experimental hematogenously disseminated candidiasis". Acta Biomaterialia 39 (2016): 133-145. http://dx.doi.org/10.1016/j.actbio.2016.05.001.
    10.1016/j.actbio.2016.05.001
  55. Santos, Carlos; Neto, Tiago; Ferreirinha, Pedro; Sousa, Hugo; Ribeiro, Joana; Bastos, Margarida M.S.M.; Faustino-Rocha, Ana I.; et al. "Celecoxib promotes degranulation of CD8+ T cells in HPV-induced lesions of K14-HPV16 transgenic mice". Life Sciences 157 (2016): 67-73. http://dx.doi.org/10.1016/j.lfs.2016.05.040.
    10.1016/j.lfs.2016.05.040
  56. França, Angela; Carvalhais, Virgínia; Vilanova, Manuel; Pier, Gerald B.; Cerca, Nuno. "Characterization of an in vitro fed-batch model to obtain cells released from S. epidermidis biofilms". AMB Express 6 1 (2016): http://dx.doi.org/10.1186/s13568-016-0197-9.
    10.1186/s13568-016-0197-9
  57. Teixeira, Luzia; Marques, Raquel M.; Ferreirinha, Pedro; Bezerra, Filipa; Melo, Joana; Moreira, João; Pinto, Ana; et al. "Enrichment of IFN-¿ producing cells in different murine adipose tissue depots upon infection with an apicomplexan parasite". Scientific Reports 6 1 (2016): http://dx.doi.org/10.1038/srep23475.
    10.1038/srep23475
  58. Ferreira, S.S.; Passos, C.P.; Madureira, P.; Vilanova, M.; Coimbra, M.A.. "Erratum: Corrigendum to "structure-function relationships of immunostimulatory polysaccharides: A review" (Carbohydrate Polymers (2015) 132 (378-396) DOI: 10.1016/j.carbpol.2015.05.079)". Carbohydrate Polymers 147 (2016): 557-558. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964573711&partnerID=MN8TOARS.
    10.1016/j.carbpol.2016.04.011
  59. Almeida, S.M.; Furtado, J.M.; Mascarenhas, P.; Ferraz, M.E.; Silva, L.R.; Ferreira, J.C.; Monteiro, M.; Vilanova, M.; Ferraz, F.P.. "Anthropometric predictors of body fat in a large population of 9-year-old school-aged children". Obesity Science and Practice 2 3 (2016): 272-281. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018166353&partnerID=MN8TOARS.
    10.1002/osp4.51
  60. Ferreira, Sónia S.; Passos, Cláudia P.; Madureira, Pedro; Vilanova, Manuel; Coimbra, Manuel A.. "Structure–function relationships of immunostimulatory polysaccharides: A review". Carbohydrate Polymers 132 (2015): 378-396. http://dx.doi.org/10.1016/j.carbpol.2015.05.079.
    10.1016/j.carbpol.2015.05.079
  61. Correia, Alexandra; Ferreirinha, Pedro; Botelho, Sofia; Belinha, Ana; Leitão, Catarina; Caramalho, Íris; Teixeira, Luzia; et al. "Predominant role of interferon-¿ in the host protective effect of CD8+ T cells against Neospora caninum infection". Scientific Reports 5 1 (2015): http://dx.doi.org/10.1038/srep14913.
    10.1038/srep14913
  62. da Costa, João Pinto; Carvalhais, Virginia; Ferreira, Rita; Amado, Francisco; Vilanova, Manuel; Cerca, Nuno; Vitorino, Rui. "Proteome signatures—how are they obtained and what do they teach us?". Applied Microbiology and Biotechnology 99 18 (2015): 7417-7431. http://dx.doi.org/10.1007/s00253-015-6795-7.
    10.1007/s00253-015-6795-7
  63. Carvalhais, Virginia; Cerveira, Frederico; Vilanova, Manuel; Cerca, Nuno; Vitorino, Rui. "An immunoproteomic approach for characterization of dormancy within Staphylococcus epidermidis biofilms". Molecular Immunology 65 2 (2015): 429-435. http://dx.doi.org/10.1016/j.molimm.2015.02.024.
    10.1016/j.molimm.2015.02.024
  64. Teixeira, Luzia; Moreira, João; Melo, Joana; Bezerra, Filipa; Marques, Raquel M.; Ferreirinha, Pedro; Correia, Alexandra; et al. "Immune response in the adipose tissue of lean mice infected with the protozoan parasiteNeospora caninum". Immunology 145 2 (2015): 242-257. http://dx.doi.org/10.1111/imm.12440.
    10.1111/imm.12440
  65. Carvalhais, Virginia; Amado, Francisco; Cerveira, Frederico; Ferreira, Rita; Vilanova, Manuel; Cerca, Nuno; Vitorino, Rui. "Immunoreactive pattern ofStaphylococcus epidermidisbiofilm against human whole saliva". ELECTROPHORESIS 36 9-10 (2015): 1228-1233. http://dx.doi.org/10.1002/elps.201500043.
    10.1002/elps.201500043
  66. Pereira, Paula; Pedrosa, Sílvia S.; Wymant, Jennifer M.; Sayers, Edward; Correia, Alexandra; Vilanova, Manuel; Jones, Arwyn T.; Gama, Francisco M.. "siRNA Inhibition of Endocytic Pathways to Characterize the Cellular Uptake Mechanisms of Folate-Functionalized Glycol Chitosan Nanogels". Molecular Pharmaceutics 12 6 (2015): 1970-1979. http://dx.doi.org/10.1021/mp500785t.
    10.1021/mp500785t
  67. Pereira, Paula; Pedrosa, Sílvia S.; Correia, Alexandra; Lima, Cristovao F.; Olmedo, Mercedes Peleteiro; González-Fernández, África; Vilanova, Manuel; Gama, Francisco M.. "Biocompatibility of a self-assembled glycol chitosan nanogel". Toxicology in Vitro 29 3 (2015): 638-646. http://dx.doi.org/10.1016/j.tiv.2014.11.004.
    10.1016/j.tiv.2014.11.004
  68. Carvalhais, Virginia; Cerca, Nuno; Vilanova, Manuel; Vitorino, Rui. "Proteomic profile of dormancy within Staphylococcus epidermidis biofilms using iTRAQ and label-free strategies". Applied Microbiology and Biotechnology 99 6 (2015): 2751-2762. http://dx.doi.org/10.1007/s00253-015-6434-3.
    10.1007/s00253-015-6434-3
  69. Carvalhais, Virginia; França, Angela; Pier, Gerald B.; Vilanova, Manuel; Cerca, Nuno; Vitorino, Rui. "Comparative proteomic and transcriptomic profile of Staphylococcus epidermidis biofilms grown in glucose-enriched medium". Talanta 132 (2015): 705-712. http://dx.doi.org/10.1016/j.talanta.2014.10.012.
    10.1016/j.talanta.2014.10.012
  70. Carneiro, Catarina; Correia, Alexandra; Collins, Tony; Vilanova, Manuel; Pais, Célia; Gomes, Andreia C.; Real Oliveira, M. Elisabete C.D.; Sampaio, Paula. "DODAB:monoolein liposomes containing Candida albicans cell wall surface proteins: A novel adjuvant and delivery system". European Journal of Pharmaceutics and Biopharmaceutics 89 (2015): 190-200. http://dx.doi.org/10.1016/j.ejpb.2014.11.028.
    10.1016/j.ejpb.2014.11.028
  71. Oliveira, Laura; Correia, Alexandra; Cristina Costa, Ana; Guerra-Gomes, Sónia; Ferreirinha, Fátima; Magalhães-Cardoso, Maria Teresa; Vilanova, Manuel; Correia-de-Sá, Paulo. "Deficits in Endogenous Adenosine Formation by Ecto-5'-Nucleotidase/CD73 Impair Neuromuscular Transmission and Immune Competence in Experimental Autoimmune Myasthenia Gravis". Mediators of Inflammation 2015 (2015): 1-16. http://dx.doi.org/10.1155/2015/460610.
    10.1155/2015/460610
  72. Passos, Cláudia P.; Cepeda, Márcio R.; Ferreira, Sónia S.; Nunes, Fernando M.; Evtuguin, Dmitry V.; Madureira, Pedro; Vilanova, Manuel; Coimbra, Manuel A.. "Influence of molecular weight on in vitro immunostimulatory properties of instant coffee". Food Chemistry 161 (2014): 60-66. http://dx.doi.org/10.1016/j.foodchem.2014.03.119.
    10.1016/j.foodchem.2014.03.119
  73. Cerca, F.; Franca, A.; Perez-Cabezas, B.; Carvalhais, V.; Ribeiro, A.; Azeredo, J.; Pier, G.; Cerca, N.; Vilanova, M.. "Dormant bacteria within Staphylococcus epidermidis biofilms have low inflammatory properties and maintain tolerance to vancomycin and penicillin after entering planktonic growth". Journal of Medical Microbiology 63 Pt_10 (2014): 1274-1283. http://dx.doi.org/10.1099/jmm.0.073163-0.
    10.1099/jmm.0.073163-0
  74. França, Angela; Carvalhais, Virgínia; Maira-Litrán, Tomás; Vilanova, Manuel; Cerca, Nuno; Pier, Gerald. "Alterations in theStaphylococcus epidermidisbiofilm transcriptome following interaction with whole human blood". Pathogens and Disease 70 3 (2014): 444-448. http://dx.doi.org/10.1111/2049-632x.12130.
    10.1111/2049-632x.12130
  75. Carvalhais, Virginia; França, Angela; Cerca, Filipe; Vitorino, Rui; Pier, Gerald B.; Vilanova, Manuel; Cerca, Nuno. "Dormancy within Staphylococcus epidermidis biofilms: a transcriptomic analysis by RNA-seq". Applied Microbiology and Biotechnology 98 6 (2014): 2585-2596. http://dx.doi.org/10.1007/s00253-014-5548-3.
    10.1007/s00253-014-5548-3
  76. Ferreirinha, Pedro; Dias, Joana; Correia, Alexandra; Pérez-Cabezas, Begoña; Santos, Carlos; Teixeira, Luzia; Ribeiro, Adília; Rocha, António; Vilanova, Manuel. "Protective effect of intranasal immunization withNeospora caninummembrane antigens against murine neosporosis established through the gastrointestinal tract". Immunology 141 2 (2014): 256-267. http://dx.doi.org/10.1111/imm.12191.
    10.1111/imm.12191
  77. Dias, Ana M.; Dourado, Joana; Lago, Paula; Cabral, Joana; Marcos-Pinto, Ricardo; Salgueiro, Paulo; Almeida, Catarina R.; et al. "Dysregulation of T cell receptor N-glycosylation: a molecular mechanism involved in ulcerative colitis". Human Molecular Genetics 23 9 (2013): 2416-2427. http://dx.doi.org/10.1093/hmg/ddt632.
    10.1093/hmg/ddt632
  78. Freitas, Ana Isabel; Vasconcelos, Carlos; Vilanova, Manuel; Cerca, Nuno. "Optimization of an automatic counting system for the quantification ofStaphylococcus epidermidiscells in biofilms". Journal of Basic Microbiology 54 7 (2013): 750-757. http://dx.doi.org/10.1002/jobm.201200603.
    10.1002/jobm.201200603
  79. Ferreira, Sílvia A.; Gama, Francisco M.; Vilanova, Manuel. "Polymeric nanogels as vaccine delivery systems". Nanomedicine: Nanotechnology, Biology and Medicine 9 2 (2013): 159-173. http://dx.doi.org/10.1016/j.nano.2012.06.001.
    10.1016/j.nano.2012.06.001
  80. Correia, Alexandra; Ferreirinha, Pedro; Costa, Amanda A; Dias, Joana; Melo, Joana; Costa, Rita; Ribeiro, Adília; et al. "Mucosal and systemic T cell response in mice intragastrically infected with Neospora caninum tachyzoites". Veterinary Research 44 1 (2013): 69. http://dx.doi.org/10.1186/1297-9716-44-69.
    10.1186/1297-9716-44-69
  81. França, Angela; Vilanova, Manuel; Cerca, Nuno; Pier, Gerald B.. "Monoclonal Antibody Raised against PNAG Has Variable Effects on Static S. epidermidis Biofilm Accumulation In Vitro". International Journal of Biological Sciences 9 5 (2013): 518-520. http://dx.doi.org/10.7150/ijbs.6102.
    10.7150/ijbs.6102
  82. Ferreira, Sílvia A.; Correia, Alexandra; Madureira, Pedro; Vilanova, Manuel; Gama, Francisco M.. "Unraveling the Uptake Mechanisms of Mannan Nanogel in Bone-Marrow-Derived Macrophages". Macromolecular Bioscience 12 9 (2012): 1172-1180. http://dx.doi.org/10.1002/mabi.201200075.
    10.1002/mabi.201200075
  83. Ferreira, Sílvia A.; Carvalho, Vera; Costa, Carla; Teixeira, João Paulo; Vilanova, Manuel; Gama, Francisco M.. "Self-Assembled Mannan Nanogel: Cytocompatibility and Cell Localization". Journal of Biomedical Nanotechnology 8 3 (2012): 473-481. http://dx.doi.org/10.1166/jbn.2012.1408.
    10.1166/jbn.2012.1408
  84. Pértile, Renata A.N.; Moreira, Susana; Gil da Costa, Rui M.; Correia, Alexandra; Guãrdao, Luisa; Gartner, Fátima; Vilanova, Manuel; Gama, Miguel. "Bacterial Cellulose: Long-Term Biocompatibility Studies". Journal of Biomaterials Science, Polymer Edition ahead-of-p ahead-of-p (2012): 1-16. http://dx.doi.org/10.1163/092050611x581516.
    10.1163/092050611x581516
  85. Silva, J. P.; Ramos, R.; Rodrigues, A. C.; Costa, R.; Guardao, L.; Soares, R.; Vilanova, M.; Domingues, L.; Gama, M. F.. "Bioactivity of the recombinant human antimicrobial peptide LL37: a key role in wound healing through vascularization". Journal of Tissue Engineering and Regenerative Medicine (2012): https://publons.com/wos-op/publon/5570678/.
  86. Decanis, Nadege. "Farnesol, a Fungal Quorum-Sensing Molecule Triggers Candida Albicans Morphological Changes by Downregulating the Expression of Different Secreted Aspartyl Proteinase Genes". The Open Microbiology Journal 5 1 (2011): 119-126. http://dx.doi.org/10.2174/1874285801105010119.
    10.2174/1874285801105010119
  87. Madureira, Pedro; Andrade, Elva Bonifácio; Gama, Bernardo; Oliveira, Liliana; Moreira, Susana; Ribeiro, Adília; Correia-Neves, Margarida; et al. "Inhibition of IL-10 Production by Maternal Antibodies against Group B Streptococcus GAPDH Confers Immunity to Offspring by Favoring Neutrophil Recruitment". PLoS Pathogens 7 11 (2011): e1002363. http://dx.doi.org/10.1371/journal.ppat.1002363.
    10.1371/journal.ppat.1002363
  88. Gil da Costa, Rui M.; Oliveira, Paula A.; Vilanova, Manuel; Bastos, Margarida M.S.M.; Lopes, Célia C.; Lopes, Carlos. "Ptaquiloside-induced, B-cell lymphoproliferative and early-stage urothelial lesions in mice". Toxicon 58 6-7 (2011): 543-549. http://dx.doi.org/10.1016/j.toxicon.2011.08.016.
    10.1016/j.toxicon.2011.08.016
  89. Cerca, Filipe; Trigo, Gabriela; Correia, Alexandra; Cerca, Nuno; Azeredo, Joana; Vilanova, Manuel. "SYBR green as a fluorescent probe to evaluate the biofilm physiological state of Staphylococcus epidermidis, using flow cytometry". Canadian Journal of Microbiology 57 10 (2011): 850-856. http://dx.doi.org/10.1139/w11-078.
    10.1139/w11-078
  90. Álvarez-Vallina, Luis; Mars, Lennart T.; Hernández, Javier; Graça, Luis; Vilanova, Manuel; Muñoz, Cecilia; Melero, Ignacio; Ortiz, Pablo; González-Fernández, África. "New trends in immunotherapy". Inmunología 30 4 (2011): 128-134. http://dx.doi.org/10.1016/j.inmuno.2011.06.003.
    10.1016/j.inmuno.2011.06.003
  91. Cerca, Filipe; França, Ângela; Guimarães, Rodrigo; Hinzmann, Mariana; Cerca, Nuno; Lobo da Cunha, Alexandre; Azeredo, Joana; Vilanova, Manuel. "Modulation of poly-N-acetylglucosamine accumulation within mature Staphylococcus epidermidis biofilms grown in excess glucose". Microbiology and Immunology 55 10 (2011): 673-682. http://dx.doi.org/10.1111/j.1348-0421.2011.00368.x.
    10.1111/j.1348-0421.2011.00368.x
  92. Cerca, F.; Andrade, F.; Franca, A.; Andrade, E. B.; Ribeiro, A.; Almeida, A. A.; Cerca, N.; et al. "Staphylococcus epidermidis biofilms with higher proportions of dormant bacteria induce a lower activation of murine macrophages". Journal of Medical Microbiology 60 12 (2011): 1717-1724. http://dx.doi.org/10.1099/jmm.0.031922-0.
    10.1099/jmm.0.031922-0
  93. Ramos, Reinaldo; Silva, João Pedro; Rodrigues, Ana Cristina; Costa, Raquel; Guardão, Luísa; Schmitt, Fernando; Soares, Raquel; et al. "Wound healing activity of the human antimicrobial peptide LL37". Peptides 32 7 (2011): 1469-1476. http://dx.doi.org/10.1016/j.peptides.2011.06.005.
    10.1016/j.peptides.2011.06.005
  94. Carvalho, Vera; Castanheira, Pedro; Madureira, Pedro; Ferreira, Sílvia A.; Costa, Carla; Teixeira, João P.; Faro, Carlos; Vilanova, Manuel; Gama, Miguel. "Self-assembled dextrin nanogel as protein carrier: Controlled release and biological activity of IL-10". Biotechnology and Bioengineering 108 8 (2011): 1977-1986. http://dx.doi.org/10.1002/bit.23125.
    10.1002/bit.23125
  95. Carvalho, Vera; Castanheira, Pedro; Faria, Tiago Q.; Gonçalves, Catarina; Madureira, Pedro; Faro, Carlos; Domingues, Lucília; et al. "Biological activity of heterologous murine interleukin-10 and preliminary studies on the use of a dextrin nanogel as a delivery system". International Journal of Pharmaceutics 400 1-2 (2010): 234-242. http://dx.doi.org/10.1016/j.ijpharm.2010.08.040.
    10.1016/j.ijpharm.2010.08.040
  96. Correia, A.; Lermann, U.; Teixeira, L.; Cerca, F.; Botelho, S.; Gil da Costa, R. M.; Sampaio, P.; et al. "Limited Role of Secreted Aspartyl Proteinases Sap1 to Sap6 in Candida albicans Virulence and Host Immune Response in Murine Hematogenously Disseminated Candidiasis". Infection and Immunity 78 11 (2010): 4839-4849. http://dx.doi.org/10.1128/iai.00248-10.
    10.1128/iai.00248-10
  97. de Oliveira, J. T.; de Matos, A. J.; Gomes, J.; Vilanova, M.; Hespanhol, V.; Manninen, A.; Rutteman, G.; et al. "Coordinated expression of galectin-3 and galectin-3-binding sites in malignant mammary tumors: implications for tumor metastasis". Glycobiology 20 11 (2010): 1341-1352. http://dx.doi.org/10.1093/glycob/cwq103.
    10.1093/glycob/cwq103
  98. Moreira, Susana; Gil Da Costa, Rui M.; Guardão, Luisa; Gärtner, Fátima; Vilanova, Manuel; Gama, Miguel. "In Vivo Biocompatibility and Biodegradability of Dextrin-based Hydrogels". Journal of Bioactive and Compatible Polymers 25 2 (2009): 141-153. http://dx.doi.org/10.1177/0883911509357865.
    10.1177/0883911509357865
  99. Teixeira, Luzia; Botelho, Ana Sofia; Mesquita, Sandro Dá; Correia, Alexandra; Cerca, Filipe; Costa, Renata; Sampaio, Paula; Castro, António Gil; Vilanova, Manuel. "Plasmacytoid and conventional dendritic cells are early producers of IL-12 in Neospora caninum -infected mice". Immunology and Cell Biology 88 1 (2009): 79-86. http://dx.doi.org/10.1038/icb.2009.65.
    10.1038/icb.2009.65
  100. Simões, Joana; Madureira, Pedro; Nunes, Fernando M.; do Rosário Domingues, Maria; Vilanova, Manuel; Coimbra, Manuel A.. "Immunostimulatory properties of coffee mannans". Molecular Nutrition & Food Research 53 8 (2009): 1036-1043. http://dx.doi.org/10.1002/mnfr.200800385.
    10.1002/mnfr.200800385
  101. Vilanova, Manuel; Correia, Alexandra. "Host defense mechanisms in invasive candidiasis originating in the GI tract". Expert Review of Anti-infective Therapy 6 4 (2008): 441-445. http://dx.doi.org/10.1586/14787210.6.4.441.
    10.1586/14787210.6.4.441
  102. Sousa, S.; Ajzenberg, D.; Vilanova, M.; Costa, J.; Darde, M.-L.. "Use of GRA6-Derived Synthetic Polymorphic Peptides in an Immunoenzymatic Assay To Serotype Toxoplasma gondii in Human Serum Samples Collected from Three Continents". Clinical and Vaccine Immunology 15 9 (2008): 1380-1386. http://dx.doi.org/10.1128/cvi.00186-08.
    10.1128/cvi.00186-08
  103. Pinto, Ricardo; Amaral, Antonio L; Ferreira, Eugenio C; Mota, Manuel; Vilanova, Manuel; Ruel, Katia; Gama, Miguel. "Quantification of the CBD-FITC conjugates surface coating on cellulose fibres". BMC Biotechnology 8 1 (2008): 1. http://dx.doi.org/10.1186/1472-6750-8-1.
    10.1186/1472-6750-8-1
  104. Madureira, P.; Baptista, M.; Vieira, M.; Magalhaes, V.; Camelo, A.; Oliveira, L.; Ribeiro, A.; et al. "Streptococcus agalactiae GAPDH Is a Virulence-Associated Immunomodulatory Protein". The Journal of Immunology 178 3 (2007): 1379-1387. http://dx.doi.org/10.4049/jimmunol.178.3.1379.
    10.4049/jimmunol.178.3.1379
  105. Botelho, A.S.; Teixeira, L.; Correia-da-Costa, J.M.; Faustino, A.M.R.; Castro, A.G.; Vilanova, M.. "Neospora caninum: High susceptibility to the parasite in C57BL/10ScCr mice". Experimental Parasitology 115 1 (2007): 68-75. http://dx.doi.org/10.1016/j.exppara.2006.06.004.
    10.1016/j.exppara.2006.06.004
  106. TEIXEIRA, L.; BOTELHO, A. S.; BATISTA, A. R.; MEIRELES, C. S.; RIBEIRO, A.; DOMINGUES, H. S.; CORREIA DA COSTA, J. M.; et al. "Analysis of the immune response to Neospora caninum in a model of intragastric infection in mice". Parasite Immunology 29 1 (2007): 23-36. http://dx.doi.org/10.1111/j.1365-3024.2006.00911.x.
    10.1111/j.1365-3024.2006.00911.x
  107. Teixeira, Luzia; Marques, Andreia; Meireles, Carla Sofia; Seabra, Ana Rita; Rodrigues, Diana; Madureira, Pedro; Faustino, Augusto M. R.; et al. "Characterization of the B-cell immune response elicited in BALB/c mice challenged with Neospora caninum tachyzoites". Immunology 116 1 (2005): 38-52. http://dx.doi.org/10.1111/j.1365-2567.2005.02195.x.
    10.1111/j.1365-2567.2005.02195.x
  108. Cerca, Nuno; Pier, Gerald B.; Vilanova, Manuel; Oliveira, Rosário; Azeredo, Joana. "Quantitative analysis of adhesion and biofilm formation on hydrophilic and hydrophobic surfaces of clinical isolates of Staphylococcus epidermidis". Research in Microbiology 156 4 (2005): 506-514. http://dx.doi.org/10.1016/j.resmic.2005.01.007.
    10.1016/j.resmic.2005.01.007
  109. Cerca, N.; Pier, G.B.; Vilanova, M.; Oliveira, R.; Azeredo, J.. "Influence of batch or fed-batch growth on Staphylococcus epidermidis biofilm formation". Letters in Applied Microbiology 39 5 (2004): 420-424. http://dx.doi.org/10.1111/j.1472-765x.2004.01601.x.
    10.1111/j.1472-765x.2004.01601.x
  110. Dourado, Fernando; Madureira, Pedro; Carvalho, Vera; Coelho, Ricardo; Coimbra, Manuel A.; Vilanova, Manuel; Mota, Manuel; Gama, Francisco M.. "Purification, structure and immunobiological activity of an arabinan-rich pectic polysaccharide from the cell walls of Prunus dulcis seeds". Carbohydrate Research 339 15 (2004): 2555-2566. http://dx.doi.org/10.1016/j.carres.2004.07.024.
    10.1016/j.carres.2004.07.024
  111. Vilanova, Manuel; Teixeira, Luzia; Caramalho, Iris; Torrado, Egidio; Marques, Andreia; Madureira, Pedro; Ribeiro, Adilia; et al. "Protection against systemic candidiasis in mice immunized with secreted aspartic proteinase 2". Immunology 111 3 (2004): 334-342. http://dx.doi.org/10.1111/j.1365-2567.2004.01819.x.
    10.1111/j.1365-2567.2004.01819.x
  112. Soares-da-Silva, I.M.; Ribeiro, J.; Valongo, C.; Pinto, R.; Vilanova, M.; Bleher, R.; Machado, J.. "Cytometric, morphologic and enzymatic characterisation of haemocytes in Anodonta cygnea". Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 132 3 (2002): 541-553. http://dx.doi.org/10.1016/s1095-6433(02)00039-9.
    10.1016/s1095-6433(02)00039-9
  113. VILANOVA; FERREIRA; RIBEIRO; ARALA-CHAVES. "The biological effects induced in mice by p36, a proteinaceous factor of virulence produced by African swine fever virus, are mediated by interleukin-4 and also to a lesser extent by interleukin-10". Immunology 96 3 (1999): 389-395. http://dx.doi.org/10.1046/j.1365-2567.1999.00629.x.
    10.1046/j.1365-2567.1999.00629.x
  114. Gama, F.M.; Vilanova, M.; Mota, M.. "Exo- and endo-glucanolytic activity of cellulases purified from Trichoderma reesei". Biotechnology Techniques 12 9 (1998): 677-681. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031709892&partnerID=MN8TOARS.
    10.1023/A:1008808803109
  115. Ferreira, P. "Purification, and biochemical and biological characterization of an immunosuppressive and lymphocyte mitogenic protein secreted by Streptococcus sobrinus". International Immunology 9 11 (1997): 1735-1743. http://dx.doi.org/10.1093/intimm/9.11.1735.
    10.1093/intimm/9.11.1735
  116. VILANOVA, M.; TAVARES, D.; FERREIRA, P.; OLIVEIRA, L.; NÓBREGA, A.; APPELBERG, R.; ARALA-CHAVES, M.. "Role of Monocytes in the Up-Regulation of the Early Activation Marker CD69 on B and T Murine Lymphocytes Induced by Microbial Mitogens". Scandinavian Journal of Immunology 43 2 (1996): 155-163. http://dx.doi.org/10.1046/j.1365-3083.1996.d01-25.x.
    10.1046/j.1365-3083.1996.d01-25.x
  117. Sequeira, T.; Vilanova, M.; Lobo-da-Cunha, A.; Baldaia, L.; Arala-Chaves, M.. "Flow Cytometric Analysis of Molt-Related Changes in Hemocyte Type in Male and Female Penaeus japonicus". The Biological Bulletin 189 3 (1995): 376-380. http://dx.doi.org/10.2307/1542156.
    10.2307/1542156
  118. Tavares, Delfina; Ferreira, Paula; Vilanova, Manuel; Videira, Arnaldo; Arala-Chaves, Mário. "Immunoprotection against systemic candidiasis in mice". International Immunology 7 5 (1995): 785-796. http://dx.doi.org/10.1093/intimm/7.5.785.
    10.1093/intimm/7.5.785
  119. ARALA-CHAVES, M.; VILANOVA, M.; RIBEIRO, A.; PINTO, J.. "I. Immunostimulatory Effect of Thalidomide in Normal C57BL/6 Mice is Compatible with Stimulation of a Highly Connected Central Immune System". Scandinavian Journal of Immunology 40 5 (1994): 535-542. http://dx.doi.org/10.1111/j.1365-3083.1994.tb03501.x.
    10.1111/j.1365-3083.1994.tb03501.x
  120. VILANOVA, M.; RIBEIRO, A.; CARNEIRO, J.; ARALA-CHAVES, M.. "II. The Effects of Thalidomide Treatment on Autoimmune-Prone NZB and MRL Mice are Consistent with Stimulation of the Central Immune System". Scandinavian Journal of Immunology 40 5 (1994): 543-548. http://dx.doi.org/10.1111/j.1365-3083.1994.tb03502.x.
    10.1111/j.1365-3083.1994.tb03502.x
  121. Esaguy, Nair; águas, Artur P.; Vilanova, Manuel; Silva, Manuel T.. "Activation of Human Neutrophils by Phorbol Ester Decreases the Cytoplasm Compactness and the Lactoferrin Content of the Granulocytes". Journal of Leukocyte Biology 50 5 (1991): 444-452. http://dx.doi.org/10.1002/jlb.50.5.444.
    10.1002/jlb.50.5.444
  122. Ribelro, Adilia dos Santos; Arala-Chaves, Mário Passalaqua; Vilanova, Manuel; Porto, Maria Teresa; Coutinho, Antonio. "Role of B and T lymphocytes in the specific immunosuppression induced by a protein released by a protein monocytes infected with African swine fever virus". International Immunology 3 2 (1991): 165-174. http://dx.doi.org/10.1093/intimm/3.2.165.
    10.1093/intimm/3.2.165
  123. ARALACHAVES, MP; RIBEIRO, AD; VILANOVA, M; PORTO, MT; SANTAREM, MG; LIMA, M. "CORRELATION BETWEEN B-CELL MITOGENICITY AND IMMUNOSUPPRESSOR EFFECTS OF A PROTEIN RELEASED BY PORCINE MONOCYTES INFECTED WITH AFRICAN SWINE FEVER VIRUS". American Journal of Veterinary Research (1988): https://publons.com/wos-op/publon/6715576/.

Intellectual property

Patent
  1. Vilanova, Manuel; Maria Delfina da Conceição Tavares Gomes; Paula Maria das Neves Ferreira da Silva; António José de Meneses Moreira da Fonseca; António Manuel Silvério Cabrita. 2009. "Vaccine against dental caries based on virulence-associated immunomodulatory extracellular proteins produced by the cariogenic bacteria Streptococcus sobrinus and Streptococcus mutans". United States.
    Expired
  2. Ferreira, Paula; Vilanova, Manuel; Delfina Tavares; Trieu-Cuot, Patrick. 2008. "Vacina contra Streptococcus agalactiae usando como antigénio alvo a gliceraldeido-3-fosfato desidrogenase (GAPDH)" produzida pela bacteria ou na sua forma recombinante". Portugal.
    Withdrawn
  3. Vilanova, Manuel. 2007. "Vaccine against Streptococcus agalactiae infection using native or recombinant S. agalactiae glyceraldheide-3-phosphate dehydrogenase (GAPDH) as a target antigen”".
    Expired
  4. Vilanova, Manuel; Ferreira, Paula; Tavares, Delfina. 2005. "Vacinas contra a cárie dentária à base de proteínas extracelulares e imunomoduladoras associadas à virulência, produzidas pelas bactérias cariogénicas Streptococcus sobrinus e Streptococcus mutans". Portugal.
    Expired

Other

Other output
  1. Candida albicans: Clinical Relevance, Pathogenesis, and Host Immunity. 2015. Correia, Alexandra; Sampaio, Paula; Vilanova, Manuel; Pais, Célia. http://dx.doi.org/10.1002/9781118644843.ch50.
    10.1002/9781118644843.ch50
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2025/01/01 - 2028/12/31 Immune-mediated mechanisms determining the course of neonatal infections caused by Staphylococcus epidermidis.
Supervisor of Mariana Fragata Miranda
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2025/01/01 - 2028/12/31 Gut-Meningeal Axis in Neonatal Bacterial Infection: Unveiling Pathophysiological Mechanisms for Targeted Therapies
Co-supervisor of Nuno Pimenta Ribeiro
 Molecular and Cell Biology (PhD)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2024/01/01 - 2027/12/31 Identification of immune-mediated mechanisms operating at the maternal-foetal interface in N. caninum infected cows.
Co-supervisor
 Biomedical Sciences
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2018 - 2023/12/06 The role of codY and pdhA in S. epidermidis biofilms dormancy, antimicrobial tolerance and survival in the host
Co-supervisor
Universidade do Minho Escola de Engenharia, Portugal
2017/01/01 - 2023/09/04 Improving immune function in newborn calves through milk replacer and starter supplementation.
Co-supervisor
 PhD in Animal Science - SANFEED (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/09/06 - 2023/05/10 Dynamics and functions of N-glycans in T cell development
Co-supervisor
 Immunology (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018 - 2022/05/25 S. epidermidis putative toxin-antitoxin module mazEF: role in VBNC formation and impact on the immune system
Co-supervisor
 Biomedical Engineering (PhD)
Universidade do Minho, Portugal
2017/01/01 - 2020/02/27 Modulation of the host immune response to a human fungal pathogen using beta-glucan-functionalized nanoparticles
Supervisor of Tânia Lima
 Biotecnologia Molecular e Celular Aplicada às Ciências da Saúde (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2012/01/01 - 2020 Prevalence of biomarkers for risk of cardiovascular disease in a child population with excess weight
Co-supervisor
 PhD in Biomedical Sciences (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015/12 - 2019/12/03 The role of iron uptake on Staphylococcus epidermidis biofilm formation and virulence.
Co-supervisor
 PhD in Bioengeneering
Universidade do Minho Escola de Engenharia, Portugal
2015 - 2018/05/22 Candida glabrata biofilms: mechanisms of antifungal resistance and matrix role
Co-supervisor
 PhD in Chemical and Biological Engineering (PhD)
Universidade do Minho Escola de Engenharia, Portugal
2015/01 - 2018/05/03 Novel insights in IBD pathogenesis: T cell receptor N-glycosylation as a new molecular mechanism
Co-supervisor
 Biotecnologia Molecular e Celular Aplicada às Ciências da Saúde (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2011 - 2016/12/13 Studies on immunity of freshwater bivalves (Unionidae family): characterization, applications as biomarker in toxic assays and antibacterial trials
Co-supervisor
 PhD in Biomedical Sciences (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2011 - 2016/04/19 Effect of modulating S. epidermidis biofilms dormancy in the biofilm physiology and host immune response
Co-supervisor
 PhD in Biomedical Sciences (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2012/09 - 2016/03/22 Study of the immune response and protective effect against neosporosis elicited by mucosal immunization with Neospora caninum antigens.
Supervisor
 Doutoramento em Ciências Veterinárias (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2011 - 2015/07/13 The role and the prevalence of icaABDC, aap and bhp genes in the virulence of Staphylococcus epidermidis portuguese isolates
Co-supervisor
 PhD in Biomedical Sciences (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2009/09 - 2013/12 Characterization of the molecular interactions between S. epidermidis biofilm infections and the host immune response
Co-supervisor
 PhD in Biomedical Engeneering (PhD)
Universidade do Minho Escola de Engenharia, Portugal
2007 - 2012/12/21 Role of secreted aspartyl proteases in Candida albicans virulence, host immune response and immunoprotection in murine disseminated candidiasis
Co-supervisor of Alexandra Correia
 PhD in Sciences - Biology
Universidade do Minho Escola de Ciências, Portugal
2007 - 2012/07/16 Development of multifunctional mannan nanogel
Co-supervisor
 PhD in Biomedical Engeneering
Universidade do Minho Escola de Engenharia, Portugal
2006/03 - 2012/04 Modulation and analysis of the Staphylococcus epidermidis biofilm physiological state.
Supervisor
 Biomedical Sciences (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2007/06 - 2010/12 Development of carrier systems for the controlled release of IL-10
Co-supervisor
 Chemical and Biological Engineering
Universidade do Minho Escola de Engenharia, Portugal
2006 - 2010 Immunobiological studies on a murine model of experimental Neospora caninum infection
Supervisor
 Biology (PhD)
Universidade de Vigo - Campus Lagoas Marcosende, Spain
2006/03 - 2009/04/17 Serotyping of Toxoplasma Gondii - Contributions to the knowledge of parasite biodiversity.
Co-supervisor
 Doutoramento em Ciências Biomédicas (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Université de Limoges, France
2004/10 - 2008/05/12 Study of immunological mechanisms of resistance or susceptibility to experimental Neospora caninum infection in mice.
Supervisor
 Biomedical Sciences (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Association member

Society Organization name Role
1989 - Current Portuguese Society of Immunology Member
2015 - 2018 Portuguese Society of Immunology President of the General Assembly
2012 - 2015 Portuguese Society of Immunology President

Journal scientific committee

Journal title (ISSN) Publisher
2018 - Current Frontiers in Immunology (1664-3224) Frontiers Media SA
2018 - Current Frontiers in Microbiology (1664-302X) Frontiers Media SA
2017/01 - Current Scientific Reports (2045-2322) Springer Science and Business Media LLC
2016/08 - Current Carbohydrate Polymers Elsevier B.V.
2018 - 2019 Heliyon (2405-8440) Elsevier