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Identification

Personal identification

Full name
Catarina Isabel de Sousa Lopes

Citation names

  • Lopes, Catarina S.

Author identifiers

Ciência ID
681C-5ABC-3934
ORCID iD
0000-0001-8561-4527
Scopus Author Id
57204046775

Addresses

  • GIMM - Gulbenkian Institute for Molecular Medicine, Avenida Professor Egas Moniz, 1649-028 Lisboa, Portugal, 1649-028, Lisboa, Lisboa, Portugal (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences - Biophysics
  • Natural sciences - Biological Sciences - Biochemical Research Methods

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Intermediate (B1) Upper intermediate (B2)
Affiliation

Science

Category
Host institution 		Employer
2024/10/01 - Current Postdoc (Research) Gulbenkian Institute for Molecular Medicine, Portugal
Projects

Grant

Designation Funders
2021/03/29 - 2024/03/28 Fibrinogen-erythrocyte interaction as a new approach on the early detection of thrombotic events in vascular diseases
PTDC/EMD-TLM/7289/2020
Research Fellow
Associação para a Investigação e Desenvolvimento da Faculdade de Medicina, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/07/01 - 2022/04/30 Using AFM to study erythrocytes biophysical properties on cardiovascular diseases and amyotrophic lateral sclerosis
COVID/BD/151823/2021
10.54499/COVID/BD/151823/2021
PhD Student Fellow
Fundação para a Ciência e a Tecnologia
Concluded
2017/05/01 - 2021/05/01 Using AFM to study erythrocyte biophysical properties changes on cardiovascular diseases and amyotrophic lateral sclerosis
PD/BD/135045/2017
PhD Student Fellow
Instituto de Medicina Molecular, Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing

Contract

Designation Funders
2019/01/01 - 2019/12/31 Instituto de Medicina Molecular
UID/BIM/50005/2019
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2024/10/01 - Current Synthetic blood cells as an alternative to blood products
101046894
Post-doc
Horizon Europe
2024/01/01 - 2024/12/31 ImPlat: A single-cell platform to validate material scaffolds and drugs for the enhanced osteointegration of biomedical implants
Project#11 IMPLAT
Researcher
Ongoing
Outputs

Publications

Book chapter
  1. Lopes, Catarina S.; Carvalho, Filomena A.; Santos, Nuno C.. "Atomic Force Microscopy: a tool for imaging, manipulating biomolecules and quantifying single-molecule interactions in biological systems". In Fluorescence Imaging and Biological Quantification, edited by Raquel Seruca; Jasjit S. Suri; J. Miquel Sanches, 49-64. CRC Press, 2017.
    10.1201/9781315121017-4
  2. Lopes, C.S.; Carvalho, F.A.; Santos, N.C.. "Atomic force microscopy: A tool for imaging, manipulating biomolecules, and quantifying single-molecule interactions in biological systems". 49-64. 2017.
Conference poster
  1. Lopes, Catarina S.; Carvalho, Filomena A.; Santos, Nuno C.. "avb3 integrin peptide inhibitors impact on fibrinogen-erythrocyte binding". Paper presented in 4th Meeting of Young Biophysicists-Biophysics Festival 2024, 2024.
  2. Gabriel, André F.; Lopes, Catarina S.; Carvalho, A. Filomena; Vaz, Sandra H.; Santos, Nuno C.; Enguita, Francisco J.; Costa, Marina C.. "Circular RNAs in cardiovascular disease: Insights from a cardiac cell model". Paper presented in EMBO Workshop on The new cardiobiology, 2024.
  3. Lopes, Catarina S.; Carvalho, Filomena A.; Weinmüller, M.; Kessler, H.; Santos, Nuno C.. "avb3 integrin peptide inhibitors impact on fibrinogen-erythrocyte binding". Paper presented in XVIII Iberian Peptide Meeting, 2023.
  4. Gabriel, André F.; Lopes, Catarina S.; Carvalho, A. Filomena; Vaz, Sandra H.; Lourenço, Diogo M.; Santos, Nuno C.; Enguita, Francisco J.; Costa, Marina C.. "Into the Heart of Cardiac Diseases: Lessons from a Cardiac Model". Paper presented in 13th EMBO Young Scientists¿ Forum, 2023.
  5. Lopes, Catarina S.; Melo, Ryan; Duarte, António; Nabais, Sofia; Freitas, Teresa; Gaspar, Ana Rita; Fonseca, Ana Mara; et al. "Erythrocyte adhesion and biomechanics on carotid artery disease patients". Paper presented in 2nd Scientific MOSBRI Conference 2023, 2023.
  6. Lopes, Catarina S.; Melo, Ryan; Duarte, António; Nabais, Sofia; Freitas, Teresa; Gaspar, Ana Rita; Fonseca, Ana Mara; et al. "Erythrocyte adhesion and biomechanics on carotid artery disease patients". Paper presented in 3rd Portuguese Young Biophysicists’ Meeting, Biophysics Festival 2023, 2023.
  7. Gabriel, André F.; Lopes, Catarina S.; Carvalho, A. Filomena; Vaz, Sandra H.; Santos, Nuno C.; Enguita, Francisco J.; Costa, Marina. "Sailing through the Surface to Unveil the Inner Workings of AC16 Cells: A Biophysical and Transcriptomic Expedition towards an Atrial Fibrillation cell model". Paper presented in XVI CAML · VI NeurULisboa PhD Students Meeting, 2023.
  8. Lopes, Catarina S.; Laborinho-Pronto, A.C.; Vasco A. Conceição; Marta Gromicho; Santos, Nuno C.; de Carvalho, Mamede; Carvalho, Filomena A.. "Evaluation of morphological and elastic changes on erythrocytes and y' fibrinogen as possible predictors of survival in Amyotrophic Lateral Sclerosis". Paper presented in 8th International Iberian Biophysics congress, 2022.
  9. Lopes, Catarina S.; Laborinho-Pronto, A.C.; Vasco A. Conceição; Marta Gromicho; Santos, Nuno C.; Carvalho, Mamede; Carvalho, Filomena A.. "Evaluation of morphological and elastic changes on erythrocytes and y’ fibrinogen as possible predictors of survival in Amyotrophic Lateral Sclerosis". Paper presented in 2nd Portuguese Young Biophysicists’ Meeting, Biophysics Festival 2022, 2022.
  10. Lopes, Catarina S.; Laborinho-Pronto, A.C.; Carvalho, Mamede; Santos, Nuno C.; Carvalho, Filomena A.. "Changes on elasticity and morphology of erythrocytes from amyotrophic lateral sclerosis patients". Paper presented in 9th AFM BioMed Conference 2019, 2019.
  11. Lopes, Catarina S.; Guedes, Ana Filipa; Fonseca, Ana Catarina; Ferro, José M. ; Santos, Nuno C.; Carvalho, Filomena A.. "Fibrinogen-erythrocyte binding as a new cerebrovascular risk factor on stroke patients". Paper presented in 12th EBSA and 10th ICBP-IUPAP Congress, 2019.
  12. Lopes, Catarina S.; Guedes, Ana Filipa; Fonseca, Ana Catarina; Ferro, José M. ; Santos, Nuno C.; Carvalho, Filomena A.. "Fibrinogen-erythrocyte binding as a new cerebrovascular risk factor on stroke patients". Paper presented in 4th UL Chemistry PhD Meeting, 2019.
  13. Lopes, Catarina S.; Guedes, Ana Filipa; Fonseca, Ana Catarina; Ferro, José M. ; Santos, Nuno C.; Carvalho, Filomena A.. "Fibrinogen-erythrocyte binding as a new cerebrovascular risk factor on stroke patients". Paper presented in XIII PhD Students Meeting,, 2019.
  14. Lopes, Catarina S.; Laborinho-Pronto, A.C.; de Carvalho, Mamede; Santos, Nuno C.; Carvalho, Filomena A.. "Changes on elasticity and morphology of erythrocytes from amyotrophic lateral sclerosis patients". Paper presented in 14th Greta Pifat Mrzljak International School of Biophysics, 2018.
  15. Lopes, Catarina S.; Laborinho-Pronto, A.C.; Carvalho, Mamede; Santos, Nuno C.; Carvalho, Filomena A.. "Changes on elasticity and morphology of erythrocytes from amyotrophic lateral sclerosis patients". Paper presented in 1st Biophysics Party, 2018.
  16. Lopes, Catarina S.; Pronto-Laborinho, A.C.; Carvalho, Mamede; Santos, Nuno C.; Carvalho, Filomena A.. "Changes on elasticity and morphology of erythrocytes from amyotrophic lateral sclerosis patients". Paper presented in 3rd UL Chemistry PhD Meeting, 2018.
  17. Lopes, Catarina S.; Pronto-Laborinho, Ana Catarina; Carvalho, Mamede; Santos, Nuno C.; Carvalho, Filomena A.. "Changes on elasticity and morphology of erythrocytes from amyotrophic lateral sclerosis patients". Paper presented in XII PhD Students Meeting, 2018.
  18. Lopes, Catarina S.; Laborinho-Pronto, A.C.; de Carvalho, Mamede; Santos, Nuno C.; Carvalho, Filomena A.. "Using AFM to study erythrocytes morphology and elasticity on Amyotrophic Lateral Sclerosis". Paper presented in Talking molecules: the networks that shape the living world, 2018.
  19. Lopes, Catarina S.; Laborinho-Pronto, A.C.; Carvalho, Mamede; Santos, Nuno C.; Carvalho, Filomena A.. "Using AFM to study erythrocytes morphology and elasticity on Amyotrophic Lateral Sclerosis". Paper presented in XX. Annual Linz Winter Workshop 2018 – Advances in Single-Molecule Research for Biology & Nanoscience, 2018.
  20. Lopes, Catarina S.; Laborinho-Pronto, A.C.; Carvalho, Mamede; Santos, Nuno C.; Carvalho, Filomena A.. "Using AFM to study erythrocytes morphology and elasticity on Amyotrophic Lateral Sclerosis". Paper presented in 2nd UL Chemistry PhD Meeting, 2017.
  21. Lopes, Catarina S.; Laborinho-Pronto, A.C.; Carvalho, Mamede; Santos, Nuno C.; Carvalho, Filomena A.. "Using AFM to study erythrocytes morphology and elasticity on Amyotrophic Lateral Sclerosis". Paper presented in Annual Meeting of the Brazilian Biophysics Society, 2017.
  22. Lopes, Catarina S.; Laborinho-Pronto, A.C.; de Carvalho, Mamede; Santos, Nuno C.; Carvalho, Filomena A.. "Using AFM to study erythrocytes morphology and elasticity on Amyotrophic Lateral Sclerosis". Paper presented in Advanced School in Biophysical Methods to Study Biomolecular Interactions, 2017.
  23. Lopes, Catarina S.; Laborinho-Pronto, A.C.; de Carvalho, Mamede; Santos, Nuno C.; Carvalho, Filomena A.. "Using AFM to study erythrocytes morphology and elasticity on Amyotrophic Lateral Sclerosis". Paper presented in 19th IUPAB congress and 11th EBSA congress, 2017.
  24. Lopes, Catarina S.; Laborinho-Pronto, A.C.; de Carvalho, Mamede; Santos, Nuno C.; Carvalho, Filomena A.. "Using AFM to study erythrocytes morphology and elasticity on Amyotrophic Lateral Sclerosis". Paper presented in Bioimaging 2016, 5th International Symposium in Applied Bioimaging – Disease in Focus, 2016.
  25. Lopes, Catarina S.; Guedes, Ana Filipa; Nogueira, J. B.; Moreira, C.; Carvalho, Filomena A.; Santos, Nuno C.. "Erythrocyte-erythrocyte adhesion promoted by fibrinogen in Essential Arterial Hypertension patients". Paper presented in 5th International Iberian Biophysics Congress, 2016.
Journal article
  1. Zita Matias; Catarina S. Lopes; Nuno C. Santos; Filomena A. Carvalho. "Nanotechnology meets medicine: applications of atomic force microscopy in disease". Biophysical Reviews (2025): http://dx.doi.org/10.1007/s12551-025-01306-w.
    10.1007/s12551-025-01306-w
  2. Catarina S. Lopes; Ana Catarina Pronto-Laborinho; Vasco A. Conceição; Teresa Freitas; Gonçalo L. Matias; Marta Gromicho; Nuno C. Santos; Mamede de Carvalho; Filomena A. Carvalho. "Erythrocytes' surface properties and stiffness predict survival and functional decline in ALS patients". BioFactors (2023): https://doi.org/10.1002/biof.2030.
    10.1002/biof.2030
  3. Catarina S. Lopes; Juliana Curty; Filomena A. Carvalho; A. Hernández-Machado; Koji Kinoshita; Nuno C. Santos; Rui D. M. Travasso. "A mathematical model of fibrinogen-mediated erythrocyte–erythrocyte adhesion". Communications Biology (2023): https://doi.org/10.1038/s42003-023-04560-4.
    10.1038/s42003-023-04560-4
  4. Maria Carvalho; Márcia M. Medeiros; Inês Morais; Catarina S. Lopes; Ana Balau; Nuno C. Santos; Filomena A. Carvalho; Ana Paula Arez. "2,3-Diphosphoglycerate and the Protective Effect of Pyruvate Kinase Deficiency against Malaria Infection—Exploring the Role of the Red Blood Cell Membrane". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24021336.
    10.3390/ijms24021336
  5. Lopes, Catarina S.. "Cholesteryl hemiazelate causes lysosome dysfunction impacting vascular smooth muscle cells homeostasis". Journal of Cell Science (2021): http://dx.doi.org/10.1242/jcs.254631.
    10.1242/jcs.254631
  6. Lopes, Catarina S.. "y' Fibrinogen as a Predictor of Survival in Amyotrophic Lateral Sclerosis". Frontiers in Cardiovascular Medicine 8 (2021): http://dx.doi.org/10.3389/fcvm.2021.715842.
    10.3389/fcvm.2021.715842
  7. Pronto-Laborinho, Ana Catarina; Lopes, Catarina S.; Santos, Nuno C.; Carvalho, Filomena A.; de Carvalho, Mamede. "Molecular biomarkers associated with respiratory insufficiency in amyotrophic lateral sclerosis". Annals of Medicine 53 sup1 (2021): S4-S5. http://dx.doi.org/10.1080/07853890.2021.1894009.
    10.1080/07853890.2021.1894009
  8. Pronto-Laborinho, A.C.; Lopes, C.S.; Conceição, V.A.; Gromicho, M.; Santos, N.C.; de Carvalho, M.; Carvalho, F.A.. "Corrigendum: ¿' Fibrinogen as a Predictor of Survival in Amyotrophic Lateral Sclerosis (Frontiers in Cardiovascular Medicine, (2021), 8, (715842), 10.3389/fcvm.2021.715842)". Frontiers in Cardiovascular Medicine 8 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85170649722&partnerID=MN8TOARS.
    10.3389/fcvm.2021.800151
Activities

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2024/02/15 - 2024/02/16 Workshop of Dynamic Cell Culture with Microfluidics - from unicellular to complex systems
Workshop
 Dynamic Cell Culture with Microfluidics - from unicellular to complex systems
Instituto Gulbenkian de Ciência, Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2024/10/15 Cientistas de Coimbra realizam estudo para deteção precoce de eventos trombóticos Cientistas da Universidade de Coimbra criaram simulações para modelar a deformação dos glóbulos vermelhos. Pretendem estudar o efeito do fibrinogénio na viscosidade do sangue e na adesão celular. No âmbito do projeto, liderado pelo Instituto de Medicina Molecular (iMM), “os especialistas estão a estudar o aumento da viscosidade sanguínea, frequentemente associado a níveis elevados da proteína fibrinogénio”. Observador
2024/05/03 Cardiologia. Detetar riscos para prevenir com cirurgias e não ter de remediar com internamento. E evitar mortes Observador