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Dina Costa Simes. Completed the PhD in Chemistry in 2003, University of Algarve, Master in Cellular Chemistry in 1997 by University of Algarve, Faculty of Sciences and Technologies and Degree in Technological Chemistry in 1990 by University of Lisbon, Faculty of Sciences. Is Assistant Professor in University of Algarve since 2003 and CEO in GenoGla Diagnostics since 2010. Published 51 articles in international peer-reviewed journals. Has 1 book chapter and 1 patent pending. Supervised 3 PhD thesis, 9 MSc dissertations and 36 LSc/BSc students and trainees. Has received 9 awards. Principal Investigator in 6 projects, Researcher in 17 projects and Supervisor in 3 projects. Research main activity on vitamin K dependent proteins associated with mineralization (cardiovascular, skin and cartilage) as potential biomarkers for ectopic calcification and chronic inflammatory-related diseases as cardiovascular disease (CVD) and osteoarthritis (OA). In vitro and ex vivo human cell culture systems developed as models for diseases functional studies and clinical translation. ELISAs for application in clinical diagnostics. Clinical studies for validation of biomarkers with diagnostics/ prognosis utility. Marine bioactive molecules with potential application in the biomedical field. Starting with the creation, as group leader of the Functional Biochemistry and Proteomics research group (FBP-CCMAR) and GenoGla Diagnostics in 2010, a wide national and international research network was established involving: R&D agreements with Hospitals and Ethical committees: Hospital de Cascais Dr. José de Almeida, Pathology, HPP-Hospital de Santa Maria de Faro, Surgery, Centro Hospitalar de Lisboa Ocidental-Hospital de Santa Cruz, Cardiothoracic surgery e Centro Hospitalar de Lisboa Central, Hospital dos Capuchos, Dermatology, Centro Hospitalar Universitário do Algarve EPE-CHUA, Nephrology, Centro Hospitalar Universitário do Algarve EPE-CHUA, Obstetrics, Centro Hospitalar Universitário do Algarve EPE-CHUA, Orthopedic, Delegação do Sul do Instituto Nacional de medicina Legal e ciências Forenses-INMLCF, Complejo Hospitalario Universitario de A Corunã, Corunha, Spain. R&D agreements with national/international Institutions: Cardiovascular Research Institute Maastricht-CARIM, Netherlands; Maastricht University Medical Centre, Netherlands; Centre Européen de Recherche en Biologie et Médecine-IGBMC, France; University Hospital Erlangen, Department of Medicine 3-Rheumatology and Immunology, Germany; Universidade NOVA de Lisboa, Portugal ; Egas Moniz-CiiEM, Portugal; Departamento de Ciências Biomédicas e Medicina, University of Algarve, Portugal;VIB-UGent Center for Medical Biotechnology, Belgium; Instituto de Investigación Biomédica de A Coruña (INIBIC), Spain ; Facultad de Ciencias del Mar y Ambientales, Cádiz, Spain; Clinical Science Technology and Intervention, Karolinska Institutet, Departement of Renal Medicine, Sweden, Stazione Zoologica "A. Dohrn", Naples, Itália, Germans Trias i Pujol Research Institute (IGTP), Barcelona, Spain. R&D agreements agreements with national/international companies: Necton, Portugal, VitaK BV, Holanda, Keypoint Group, Portugal, Kintsugi Therapeutics, Spain, Convergence Partners AG, Switzerland.
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Identification

Personal identification

Full name
Dina Costa Simes

Citation names

  • Simes, Dina
  • SIMES DC

Author identifiers

Ciência ID
6819-BCBC-67BB
ORCID iD
0000-0002-5145-4753
Researcher Id
N-2789-2014
Scopus Author Id
6602098574

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Natural sciences - Biological Sciences - Biochemistry
  • Medical and Health Sciences - Health Sciences - Nutrition, Dietetics

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Portuguese (Mother tongue)
Education
Degree Classification
2003
Concluded
 Química (Doutoramento)
Universidade do Algarve - Campus de Gambelas, Portugal
"Purification, bioochemical characterization and localization at single cell resolution of matrix Gla protein (MGP) and bone Gla protein (BGP) in the teleost fish Argyrosomus regius" (THESIS/DISSERTATION)
1997
Concluded
 Química Celular (Mestrado)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
"Purification and characterization of metallothionein from the clam Ruditapes decussatus" (THESIS/DISSERTATION)
1990
Concluded
 Química Tecnológica (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
Affiliation

Science

Category
Host institution 		Employer
2007/03/01 - 2007/04/01 Visiting Researcher (Research) University of California San Diego, United States
University of California San Diego, United States
2003/02/01 - 2003/04/01 Visiting Researcher (Research) University of California San Diego, United States
University of California San Diego, United States
2002/02/01 - 2002/04/01 Visiting Researcher (Research) Centre National de la Recherche Scientifique, France
2001/02/01 - 2001/04/01 Visiting Researcher (Research) University of California San Diego, United States
University of California San Diego Division of Biological Sciences, United States
2000/02/01 - 2000/04/01 Visiting Researcher (Research) University of California San Diego, United States
University of California San Diego, United States
1995/06/01 - 1998/01/01 Visiting Researcher (Research) Universidade Nova de Lisboa, Portugal
Universidade Nova de Lisboa Departamento de Química, Portugal
1992/03/03 - 1992/10/01 Visiting Researcher (Research) Universiteit Gent, Belgium
Universiteit Gent Faculteit Wetenschappen, Belgium
1989/06/15 - 1989/10/01 Visiting Researcher (Research) Technische Universiteit Eindhoven, Netherlands
Technische Universiteit Eindhoven, Netherlands

Teaching in Higher Education

Category
Host institution 		Employer
2023/12/02 - Current Associate Professor (University Teacher) Universidade do Algarve, Portugal
Universidade do Algarve, Portugal
2003/01/15 - 2023/12/01 Assistant Professor (University Teacher) Universidade do Algarve - Campus de Gambelas, Portugal
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
1999/01/01 - 2003/01/14 Assistant (University Teacher) Universidade do Algarve - Campus de Gambelas, Portugal
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
1993/12/31 - 1998 Trainee Assistant (University Teacher) Universidade do Algarve - Campus de Gambelas, Portugal
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal

Positions / Appointments

Category
Host institution 		Employer
2002/10/01 - 2018/09/01 FCT-Mobility Coordinator Universidade do Algarve - Campus de Gambelas, Portugal
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal

Others

Category
Host institution 		Employer
2009/04/01 - Current CEO GenoGla Diagnostics, Portugal
1991/04/01 - 1993/04/01 Research contract Universidade de Lisboa Instituto Superior Técnico, Portugal
Universidade de Lisboa Instituto Superior Técnico, Portugal
Projects

Grant

Designation Funders
2024/11/01 - 2027/10/30 XtremeGourmet 2.0 – Gastronomia e alimentação saudável com plantas halófitas
COMPETE2030-FEDER-01195200
Researcher
Centro de Ciências do Mar, Portugal
Ongoing
2021/03 - 2025/03 ALGAE4IBD FROM NATURE TO BEDSIDE- ALGAE BASED BIO COMPOUND FOR PREVENTION AND TREATMENT OF INFLAMMATION, PAIN AND IBD
101000501 - Algae4IBD
Researcher
Centro de Ciências do Mar, Portugal
 Horizon 2020 Framework Programme
Ongoing
2021/03/10 - 2023/12/31 Exploring a novel and sustainable sea-based diet supplement to promote longevity and quality of life in a pandemic era (NutriSafe)
C600701226-00179866
Principal investigator
Universidade do Algarve - Campus de Gambelas, Portugal
Ongoing
2021 - 2023 Exploring the therapeutic application of Gla-rich protein (GRP) in inflammation-related diseases using natural bioengineered nanovesicles (FlameGRP)
EXPL/BTM-TEC/0990/2021
Researcher
Centro de Ciências do Mar, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2017 - 2020 RED transfronteriza para el desarrollo de productos innovadores con microalgas, Programa de Cooperacão da União Europeia INTERREG VA POCTEP-055_ALGARED_PLUS_E Espanha Portugal.
0055_ALGARED_PLUS_5_E
Researcher
Universidade do Algarve, Portugal
 POCTEP
Ongoing
2013/05/01 - 2015/12/31 New insigths into the mechanism of vascular calcification in chronic kidney disease (CKD): the role of GRP
PTDC/BIM-MEC/1168/2012
Researcher
Hospital de Faro, Portugal

Centro de Ciências do Mar, Portugal

Universiteit Maastricht Cardiovascular Research Institute Maastricht, Netherlands
Fundação para a Ciência e a Tecnologia
Concluded
2013/05 - 2015/12 New insigths into the mechanism of vascular calcification in chronic kidney disease (CKD): the role of GRP
Provided by PTCRIS: 126102
 Fundação para a Ciência e a Tecnologia
2012/02/01 - 2015/09/30 Insights into Gla-rich Protein (GRP) function and molecular mechanism of action in vascular calcification (BioGlaGRP)
PTDC/SAU-ORG/117266/2010
Researcher
Centro de Ciências do Mar, Portugal

Hospital de Faro, Portugal

Universiteit Maastricht Cardiovascular Research Institute Maastricht, Netherlands
Fundação para a Ciência e a Tecnologia
Concluded
2011/01 - 2014/06 A new approach for the identification of osteoarthritis terapeutic targets:The application of 2D-DIGE proteomics
Provided by PTCRIS: 112832
112832
PTDC/SAU-ORG/112832/2009
Principal investigator
Hospital de Faro, Portugal

Centro de Ciências do Mar, Portugal
Fundação para a Ciência e a Tecnologia, I.P.

Fundação para a Ciência e a Tecnologia
Concluded
2010/01/01 - 2013/07/31 Studies for the establishement of GRP as a biomarker for vascular calcification
PTDC/SAU-ESA/101186/2008
Principal investigator
Hospital de Faro, Portugal

Centro Hospitalar de Lisboa Central EPE, Portugal

Universidade do Algarve, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/01 - 2013/07 Studies for the establishement of GRP as a biomarker for vascular calcification
101186
Provided by PTCRIS: 101186
 Fundação para a Ciência e a Tecnologia, I.P.
2008/08/01 - 2011/11/30 HYDRAA - Improved dietary nitrogen formulations for marine fish larvae: effects on growth performance and skeletal formation
PTDC/MAR/71685/2006
71685
Provided by PTCRIS: 71685
Researcher
Instituto Português do Mar e da Atmosfera, Portugal

Centro de Ciências do Mar, Portugal
Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2007/08 - 2010/07 Characterization of isoprenoids biosynthesis and determination of potential therapeutic targets
72083
Provided by PTCRIS: 72083
PTDC/CVT/72083/2006
Researcher
Centro de Ciências do Mar, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.

Fundação para a Ciência e a Tecnologia
Concluded
2005/09/01 - 2008/06/30 MGP functional role regarding local regulation of extracellular matrix mineralization-Identification of the structural motifs responsible for its function
POCI/MAR/57921/2004
57921
Provided by PTCRIS: 57921
Principal investigator
Centro de Ciências do Mar, Portugal
 Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2005/06 - 2008/06 Spatial-temporal pattern of expression and regulation of Matrix Gla Protein (MGP) during early development in X. laevis
Provided by PTCRIS: 58677
58677
Researcher
Centro de Ciências do Mar, Portugal

Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2005/11 - 2007/12 Dietary amino acids and skeletal development in white bream (Diplodus spp.)
Provided by PTCRIS: 61623
61623
Provided by PTCRIS: 83408
83408
 Fundação para a Ciência e a Tecnologia, I.P.
2003/01 - 2006/01 Effect of extracellular calcium on MGP gene expression
POCTI/BCI/48748/2002
Researcher
Centro de Ciências do Mar, Portugal
 Fundação para a Ciencia e Tecnologia
Concluded
2003/01 - 2006/01 Mineralization processes in marine and fresh water teleosts: function of Gla proteins (Matrix Gla and osteocalcin)
POCTI/CVT/42098/2002
Researcher
Fundação para a Ciencia e Tecnologia
Concluded
1998/01 - 2000 Characterization of Matrix Gla and Bone Gla proteins gene expression in different developmental stages of the seabream Sparus aurata.
PRAXIS/ BIA/469/94
Researcher
Centro de Ciências do Mar, Portugal
 Fundação para a Ciencia e Tecnologia
Concluded

Contract

Designation Funders
2019/03 - Current SPN 2019 Application of Gla-rich Protein (GRP) in diagnostic and therapeutic of cardiovascular disease in Chronic Kidney Disease patients.
SPN 2019
Researcher
Hospital de Faro, Portugal

Centro de Ciências do Mar, Portugal
Sociedade Portuguesa de Nefrologia
Ongoing
2019 - Current Characterization of bioengineered extracellular vesicles (EVs) loaded with Gla rich Protein: a proteomic approach (EU/H2020 EPIC-XS project #7)
EU/H2020 EPIC-XS project #7
Principal investigator
Centro de Ciências do Mar, Portugal

VIB UGent Centrum voor Medische Biotechnologie, Belgium
Horizon 2020
Ongoing
2018 - Current GreenCoLAB- Laboratório Colaborativo de Tecnologias e Produtos Verdes de Oceano
GreenColab
Researcher
Centro de Ciências do Mar, Portugal
Ongoing
2017/04 - Current SPN 2016 Gla-rich protein (GRP) associated to circulating calciprotein particles (CPP) and extracellular vesicles (EVs) as a novel marker of vascular calcification stress in diabetic with chronic kidney disease (CKD).
SPN 2016
Researcher
Hospital de Faro, Portugal

Centro de Ciências do Mar, Portugal
Sociedade Portuguesa de Nefrologia
Ongoing
2021/04/01 - 2023/12/31 NutriSafe: Exploring a novel and sustainable sea-based diet supplement to promote longevity and quality of life in a pandemic era
ALG-01-0145-FEDER-072583
Principal investigator
Universidade do Algarve - Campus de Gambelas, Portugal
Concluded
2021/11/21 - 2022/10/31 BIORREMEDIACIÓN DE DRENAJES ÁCIDOS DE ZONAS MINERAS DE LA EURORREGIÓN AAA UTILIZANDO MICROALGASUTILIZANDO MICROALGAS
SUBVENCIÓN/ES 21/22
Researcher
Centro de Ciências do Mar, Portugal

Universidad de Huelva, Spain
Ongoing
2020 - 2021 NUEVOS USOS DE SUBPRODUCTOS AGROALIMENTARIOS DE LA EURORREGIÓN ALENTEJO-ALGARVE-ANDALUCÍA UTILIZANDO MICROALGAS
SUBVENCIÓN/ES 20/21
Researcher
Universidad de Huelva, Spain

Centro de Ciências do Mar, Portugal
Concluded
2018/11/01 - 2019/05/31 Bioexplora: identificación de sustancias bioactivas de microalgas extremófilas obtenidas de zonas mineras de la Eurorregión Alentejo-Algarve-Andalucía
Bioexplora 2018/2019
Researcher
Universidad de Huelva, Spain

Centro de Ciências do Mar, Portugal
Concluded
2018/11/26 - 2018/12/14 Discovery of dermato-protective properties of marine 5-thiohistidines.
PID5650 VIDVID10862
Supervisor
Centro de Ciências do Mar, Portugal
Concluded
2017/11/01 - 2017/11/15 Sustainable and high-efficient production of Tetraselmis suecica as innovative product with high biological value for cosmeceutical market
TA2790
Supervisor
Centro de Ciências do Mar, Portugal
Concluded
2017/10/02 - 2017/10/17 Discovery of cosmeceutical and pharmaceutical properties of a promising marine natural product
TA2803
Supervisor
Centro de Ciências do Mar, Portugal
Concluded
2014 - 2017 Expression and purification of Gla Rich protein in baculovirus for its use in functional and structural studies.
EU/INSTRUCT PID1003201
Researcher
Institut de Génétique et de Biologie Moléculaire et Cellulaire, France

Centro de Ciências do Mar, Portugal
EU/INSTRUCT

Horizon 2020
Concluded
2016 - 2016 Foresight Workshop, horizon scanning Exploitation and Legal Aspects on Marine Genetic and Chemical Resources
Euromarine 2016
Researcher
Consiglio Nazionale delle Ricerche Area di Ricerca di Napoli 1, Italy
Concluded
2012/03/01 - 2015/03/01 Application of 2DE proteomics to human articular cartilage and synovial fluid for identification of new osteoarthritis biomarkers (EU/H2020-PRIME-XS-72)
EU/H2020 (PRIME-XS-72)
Principal investigator
Centro de Ciências do Mar, Portugal

VIB UGent Centrum voor Medische Biotechnologie, Belgium
Horizon 2020
Concluded
2010 - 2012 Desenvolvimento de um alimento microencapsulado para larvas de peixes
QREN MICALA13380
Researcher
Centro de Ciências do Mar, Portugal

Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
Concluded
Outputs

Publications

Book chapter
  1. Viegas, Carla S.B.; Simes, Dina C.. "Inflammation and Calcification in the Vascular Tree; Insights Into Atherosclerosis". In Immunity and Inflammation in Health and Disease, 189-201. Elsevier, 2018.
    10.1016/b978-0-12-805417-8.00015-9
Conference abstract
  1. Simes, Dina. "Gla-Rich Protein-loaded EVs for cardiovascular research: Production via baculovirus-insect and human cell systems". Belgrad, 2024.
  2. Dina Simes. Corresponding author: Dina Simes. "Algas na praia: uma iniciativa de ciência cidadã para monitorizar acumulações de algas na costa portuguesa. Oral communication". 2021.
    Published
  3. Dina Simes. Corresponding author: Dina Simes. "Preliminary Structural characterization of human Gla Rich Protein involved in the inhibition of mineral crystal formation in vascular calcification. (Oral poster)". Paper presented in XXI National Congress of Biochemistry, ÉVORA, 2021.
    Published
  4. Simes, Dina; Carla S. B. Viegas. Corresponding author: Simes, Dina. "Unveiling the complexity of extracellular vesicles (EVs) associated with vascular calcification: Heterogeneous populations with different characteristics and features. (Oral Presentation).". 2021.
    Published
  5. SIMES DC. "Exploring the potential of the microalgae tetraselmis striata ctp4 as a novel source of anti-inflammatory compounds.". Paper presented in XII European Conference on Marine Natural Products. Virtual Conference, 2021.
  6. Devi, Meena; Awasthi, Shachi. "Nanoencapsulation as a novel delivery approach for therapeutic applications of gla-rich protein (GRP)". Paper presented in 4th congress of CiiEM on “Health, Well-Being and Ageing in the 21st Century”, Almada, 2020.
    10.1063/1.5122562
  7. Araújo, Nuna; Viegas, Carla; MARREIROS, CATARINA; Simes, Dina. "Amentadione, a meroditerpenoide from brown algae with capacity of modulating osteoarthritis responses, in a close-to-in-vivo OA model". Paper presented in Joint XVI International Symposium on Marine Natural Products and XI European Conference on Marine Natural Products, Peniche, Leiria, 2019.
    Published
  8. Viegas, C.S.B.; Simes, Dina; Williamson, M.K.; Laizé, Vincent; Price, Paul A.; Cancela, M. Leonor. "Identification of an MGP/OC hybrid gene in the Adriatic sturgeon (Acipencer naccarii), an ancient bony fish with a cartilaginous endoskeleton". Paper presented in 35th ECTS Meeting, May 24-28, Barcelona, Spain, 2008.
    Published
Conference paper
  1. Simes, Dina. "Vascular calcification is mediated by different populations of extracellular vesicles (EVs) with specific molecular profiles and differential effects on vascular tissue inflammation". Lyon, 2024.
    Published
  2. Simes, Dina. "Gla Rich Protein is associated with vascular calcification, inflammation and mineral markers in Peritoneal Dialysis Patients". Paper presented in Congress EuroPD 2023, Bruges, 2023.
    Published
  3. "Amentadione is a new modulating agent for osteoarthritis in an ex-vivo co-culture preclinical assay". 2019.
    10.1080/07853890.2018.1561895
  4. Simes, Dina. "Gla-Rich Protein as a Novel Marker for Calcifications in Diabetic Patients with CKD". 2018.
    10.1093/ndt/gfy104.SP430
  5. Simes, Dina. "Gla-rich protein, a vitamin K-dependent protein involved in inflammation and calcification-related diseases". 2018.
    10.1080/07853890.2018.1427452
  6. Viegas, Carla; Santos, Lúcia; Macedo, Anjos; Morais, Rute; Silva, Ana; Neves, Pedro; Matos, António; Vermeer, Cees; Simes, Dina. "MO055CIRCULATING CALCIPROTEIN PARTICLES AND EXTRACELLULAR VESICLES AS NOVEL PLAYERS IN CHRONIC KIDNEY DISEASE VASCULAR CALCIFICATION. A ROLE FOR GLA-RICH PROTEIN". Paper presented in ERA-EDTA 54th Annual Congress, Madrid, 2017.
    10.1093/ndt/gfx123.mo055
  7. Rafael, Marta; Cavaco, Sofia; Viegas, Carla; Santos, Sofia; Ramos, Acacio; Luis, Ines; Costa, Ruben; et al. "Involvement of Gla rich protein with pathological calcification during osteoarthritis. Insights into its ¿-carboxylation status". Paper presented in European Calcified Tissue Society, Prague, 2014.
    10.1530/boneabs.3.pp373
  8. Roberto, V.; Cavaco, S.; Simes, Dina; Gavaia, Paulo J.; Cancela, Leonor. "Mgp expression and accumulation in heart and kidney of turbot (Scophthalmus maximus)". 2009.
  9. Viegas, Carla; Simes, Dina; Williamson, M.K.; Laizé, V.; Price, PA; Cancela, ML. "Identification of an hybrid gene in the Adriatic sturgeon (Acipenser naccarii), an ancient bony fish with a cartilaginous endoskeleton". Paper presented in 35th ECTS Meeting, Barcelona, 2008.
  10. Viegas, C. S. B.; Simes, D. C.; Williamson, M. K.; Laize, V.; Price, P.; Cancela, L.. "Identification of an MGP/OC hybrid gene in the adriatic sturgeon (acipencer naccarit), an ancient bony fish with a cartilaginous endoskeleton". Paper presented in 35th ECTS Meeting, Barcelona, 2008.
  11. Cancela, Leonor; Laizé, Vincent; Simes, Dina; Gavaia, Paulo J.; Conceição, N.; Viegas, C. S. B.; Pombinho, A. R.; et al. "Proteínas gla do osso e cartilagem: importância dos anfíbios e peixes como modelos biológicos para elucidação da sua função e evolução - gla proteins in bone and cartilage: the importance of fish and amphibian models to understand their function and evolution". 2005.
  12. Gavaia, Paulo J.; Simes, Dina; Ortiz-Delgado, J. B.; Sarasquete, C.; Cancela, Leonor. "Simultaneous detection of osteocalcin and matrix gla protein in developmental stages of zebra fish (Danio rerio)". 2003.
    http://dx.doi.org/10.1007/s00223-003-5002-5
Conference poster
  1. Simes, Dina. "Vascular calcification is mediated by different populations of extracellular vesicles (EVs) with specific molecular profiles and differential effects on vascular tissue inflammation". 2024.
  2. SIMES DC; Viegas, Carla; Varela, João; Dorit Avni; Silva, Mélanie; Barreira, Luísa. "A PATHWAY TOWARDS BETTER HEALTH: FIGHTING INFLAMMATION WITH NOVEL MICROALGAE-BASED NATURAL COMPOUNDS". Paper presented in ALGAEUROPE 2023, 2023.
  3. Dorit Avni; Nathalie Shagug; Y Eilam; Antonio Marzochella; Daria Maria Monti; Antonino Pollio; Barreira, Luísa; et al. "ALGAE AS A SUSTAINABLE FOOD BRIDGES THE REALMS OF HEALTH AND ENVIRONTMENTAL". Paper presented in ALGAEUROPE 2023, 2023.
  4. Viegas, Carla; Ana Paula Silva; Marilia Faisca; Schurgers, Leon; Simes, Dina. "Establishment of Reference Intervals for Gla Rich Protein Serum levels and variations in a Peritoneal Dialysis Population". Paper presented in Egas Moniz International Scientific Congress (CiiEM), 2023.
  5. Simes, Dina. "Calcifying extracellular vesicles containing Gla-rich protein (GRP) modulate inflammatory responses in human macrophages". 2023.
  6. Simes, Dina. Corresponding author: Simes, Dina. "Projeto piloto para criação de um questionário de frequência alimentar para determinar aporte de vitamina K numa população mediterrânica.". Paper presented in 1º Congresso da Rede de Instituições do Ensino Superior para a Salvaguarda da Dieta Mediterrânica, 2021.
  7. Simes, Dina; Marreiros, C.; Ismael, K.; Viegas, C.; Araújo, N.; Andrade, M.; Rosa, B.; et al. "Anti-inflammatory Activity of Microalgae-derived Bioatives with Dermoprotective Application". Paper presented in Joint XVI International Symposium on Marine Natural Products and XI European Conference on Marine Natural Products, 2019.
  8. Simes, Dina; BrancaccioI, M.; Militol, A.; Viegas, C.. "Marine 5-thiohistidines as protective molecules from skin damage". Paper presented in The 44th FEBS Congress, 2019.
  9. Simes, Dina; Araújo, N.; Viegas, C.; Pontes, J.; Magalhães, J.; Blanco, F.; Macedo, A.; Grenha, A.. "Nano-encapsulation of Gla-rich protein (GRP) and potential added value as a therapeutic agent for osteoarthritis". Paper presented in 21st International Symposium on Microencapsulation, 2017.
  10. Simes, Dina; Morais, R.; Viegas, C.; Matos, A.; Macedo, A.. "Application of TEM Techniques for the Study of Vascular Calcification: Monitoring Extracellular Vesicles and NanoGold Immunodection of Fetuin-A, GRP and CD9". Paper presented in Ultrapath XVII, Society for Ultrastructural Pathology, 2016.
  11. Simes, Dina; Araújo, N.; Perrolas, I.; Costa, R.; Viegas, C.; Ramos, A.; Zubia, E.. "Exploring meroterpenoids from brown algae as novel therapeutic drugs for osteoarthriti". Paper presented in XV International Symposium on Marine Natural Products, 2016.
  12. Simes, Dina; Macedo, A.; Viegas, C.; Matos, A.. "Extracellular Vesicles and Circulating Fetuin-Mineral Complexes in Vascular Calcification; Studies by EM Techniques". Paper presented in 4th Joint Congress of the Portuguese and Spanish Societies of Microscopy, "Microscopy at the Frontiers of Science 2015, 2015.
  13. Simes, Dina; Morais, R.; Macedo, A.; Viegas, C.; Matos, A.. "Electron Microscopy Contribution to the Study of Vascular Calcification Process: Monitoring Extracellular Vesicles Biogenesis and Mineralization". Paper presented in First International Congress of CiiEM. From Basic Sciences to Clinical Research, 2015.
  14. Simes, Dina; Rafael, M.; Cavaco, S.; Viegas, C.; Santos, S.; Ramos, A.; Luis, I.; et al. "Involvement of Gla rich protein (GRP) with pathological calcification during osteoarthritis. Insights into its ¿-carboxylation status". Paper presented in European Calcified Tissue Society (ECTS), 2014.
  15. Simes, Dina; Santos, L.; Rafael, M.; Viegas, C.. "Studies towards unveiling potential interaction partners of Gla-rich protein (GRP), a potential regulator of pathological calcification related diseases". Paper presented in XVIII Congress of the Portuguese Biochemical Society, 2014.
  16. Simes, Dina; Costa, R.M.; Viegas, C.; Rafael, M.; Marques, G.; Silva, Z.; Videira, P.. "Study of mineralization-related vitamin K-dependent proteins associated with leukocytes in mineralization and inflammatory processes". Paper presented in XVIII Congress of the Portuguese Biochemical Society, 2014.
  17. Simes, Dina; Rafael, M.; Viegas, C.; Miralles-Ferrer, N.; Vermeer, C.. "Production of functional recombinant Gla-rich protein (GRP) for clinical diagnosis". Paper presented in Practical workshop on Production, purification and characterization of macromolecular complexes IGBMC, 2012.
  18. Simes, Dina; Viegas, C.; Morera, J.L.; Teixeira, A.; Joao, A.; Ferreira, A.; Neves, P.; et al. "GRP is a new VKD protein associated with ectopic calcifications and potential application in clinical diagnostics". Paper presented in FASEB Summer Research Conferences on Molecular, Structural & Clinical Aspects of VitaminK & Vitamin K Dependent Proteins, 2011.
  19. Simes, Dina; Viegas, C.; Cavaco, S.; Ramos, A.; Silva, J.; Morera, J. L.; Teixeira, A.; et al. "Insights into the relation between Gla rich protein (GRP) and Osteoarthritis". Paper presented in FASEB Summer Research Conferences on Molecular, Structural & Clinical Aspects of Vitamin K & Vitamin K Dependent Proteins, 2011.
  20. Simes, Dina; Herfs, M.; Smit, E.; Viegas, C.; Vermeer, C.. "Gla-rich protein: a new vitamin K-dependent protein associated with inflammation". Paper presented in FASEB Summer Research Conferences on Molecular, Structural & Clinical Aspects of Vitamin K & Vitamin K Dependent Proteins, 2011.
  21. Simes, Dina; Viegas, C.; Cavaco, S.; Neves, P.L.; Joao, A.; Williamson, M.K.; Price, P.A.; Cancela, L.. "GRP is a New Vitamin K Dependent Protein and a Possible Ectopic Calcification Biomarker with Diagnostic Implications". Paper presented in BIT’s 3rd Annual Protein and Peptide Conference, 2010.
  22. Simes, Dina; Oliveira, D.; Cavaco, I.; Silva, T.S.; Cordeiro, D.C.; Rodrigues, P.M.. "Proteomic analysis of nacre soluble matrix proteins from the oyster Crassostrea Gigas". Paper presented in 4th EUPA meeting and 6th ProCura meeting,, 2010.
  23. Simes, Dina; Cavaco, S.; Viegas, C.. "2-DE Proteomics of human articular cartilage for the identification of osteoarthritis biomarkers - procedures optimization". Paper presented in 4th EUPA meeting and 6th ProCura meeting, 2010.
  24. Simes, Dina; Fazenda, C.; Conceiçao, N.; Cancela, L.. "Development of molecular and cellular tools to study the function of skeletal Gla-containg proteins in sturgeon". Paper presented in Workshop - Interdisciplinary Approaches in Fish Skeletal Biology, 2009.
  25. Simes, Dina; Laize, V.; Viegas, C.; Cancela, L.. "Evolutionary relationship of bone-associated Gla proteins". Paper presented in 2nd meeting of the European Society for Evolutionary Development Biology, 2008.
  26. Simes, Dina; Viegas, C.; Cancela, L.. "Molecular cloning and regulation of the genes encoding Matrix and Bone Gla proteins from Sturgeon. Studies towards understanding the evolution of their molecular mechanism of action". Paper presented in Seminários Mar e Ambiente, 2006.
  27. Simes, Dina; Gavaia, P.; Ortiz-Delgado, J.B.; Cancela, M.L.; Sarasquete, C.. "Acumulación y expresión de proteínas gla de la matriz en lenguado, Solea senegalensis y el pez cebra Danio rerio". Paper presented in IX Congreso nacional de acuicultura, 2003.
  28. Simes, Dina; Coelho, R.; Alves, D.; Frazão, C.; Cancela, M.L.; Carrondo, M.A.. "Crystallization of Osteocalcin from a Marine Fish, Argyrosomus regius". Paper presented in IX International Conference on the crystallization of Biological macromolecules (ICCBM), 2002.
  29. SIMES DC. "Obtention of fish MGP specific antibodies and characterization of specific MGP accumulation in Argyrosomus regius bone and calcified cartilage". Paper presented in FEBS Lisbon 2001, PABMB, 2001.
  30. Pinto, J. P.; Gavaia, Paulo J.; Simes, Dina; Kelsh, R. N.; Cancela, Leonor; Simes, Dina; Pinto, J.; et al. "Localization of osteocalcin (BGP) during fish (Sparus aurata) development by in situ hybridization and immunohistochemistry: comparison between gene expression/protein distribution and skeletal mineralization". Paper presented in FEBS Lisbon 2001, PABMB, 2001.
  31. Simes, Dina; Pinto, J.P.; Rodrigues, P.; Macedo, L.; Goodfelow, B.; Williamson, M.K.; Price, P.A.; Cancela, M.L.. "Identification of invariant amino acid residues in BGP from fish to mammals suggests a conserved function throughout vertebrate evolution". Paper presented in 20th Conference of European Comparative Endocrinologists, 2000.
  32. Simes, Dina; Cancela, M.L.; Rodrigues, P.; Conceição, N.; Reia, J.P.; Williamson, M.K.; Price, P.A.. "Expression of MGP in fish and amphibians: A model system to study the evolution of MGP function". Paper presented in 20nd Annual Meeting of the American Society for Bone and Mineral Research, 2000.
  33. Simes, Dina; Williamson, M.K.; Price, P.A.; Cancela, M.L.. "Identification of matrix Gla protein in a teleost fish: calcified cartilage and not bone as the primary site of expression in fish". Paper presented in XII Biochemistry National Congress, 2000.
  34. Simes, Dina; Costa, C.; Moura, I.; Moura, J.J.G.. "The equilibrium monomer dimer of Cytochrome c550 from Paracoccus denitrificans NMR spectroscopic studies". Paper presented in Gordon Research Conference “Magnetic Nuclear Resonance in Biology and Medicin, 1998.
  35. Simes, Dina; Bebiano, M.J.; Moura, J.J.G.. "Purification and parcial caracterization of metallothioneins from the clam Ruditapes decussatus". Paper presented in 3ª Conferência de Química Inorgânica “Síntese, Reactividade e Estrutura em Química Inorgânica”,, 1997.
  36. Simes, Dina; J. Costa; Cavaco, I.; Villas Boas, L.. "Reactions of Copper(II) and oxovanadium (IV) glycine schiff base complexes with acetone". Paper presented in Second Italian- Portuguese- Spanish Meeting in Inorganic Chemistry, 1992.
Encyclopedia entry
  1. Simes, Dina. "Vitamin K a nutraceutical with impact in health". , 2020. http://dx.doi.org/10.32545/encyclopedia202001.0002.v1.
    10.32545/encyclopedia202001.0002.v1
Journal article
  1. Carla Viegas; Joana Carreira; Teresa M. Maia; Anjos L. Macedo; António P. Matos; José Neves; Dina Simes. "Gla Rich Protein (GRP) Mediates Vascular Smooth Muscle Cell (VSMC) Osteogenic Differentiation, Extracellular Vesicle (EV) Calcification Propensity, and Immunomodulatory Properties". International Journal of Molecular Sciences (2024): https://doi.org/10.3390/ijms252212406.
    10.3390/ijms252212406
  2. Pinto, Ezequiel; Viegas, Carla; Martins, Paula Ventura; Marreiros, Catarina; Nascimento, Tânia; Schurgers, Leon; Simes, Dina. "Mediterranean Diet Favors Vitamin K Intake: A Descriptive Study in a Mediterranean Population". Nutrients 16 8 (2024): 1098. http://dx.doi.org/10.3390/nu16081098.
    Open access • 10.3390/nu16081098
  3. Sabotic, Jerica; Bayram, Engin; Ezra, David; Gaudêncio, Susana P.; Haznedaroglu, Berat Z.; Janež, Nika; Ktari, Leila; et al. "A guide to the use of bioassays in exploration of natural resources". Biotechnology Advances 71 (2024): 108307. http://dx.doi.org/10.1016/j.biotechadv.2024.108307.
    10.1016/j.biotechadv.2024.108307
  4. Marreiros, Catarina; Viegas, Carla; Guedes, Anabela Malho; Silva, Ana Paula; Águas, Ana Catarina; Faísca, Marília; Schurgers, Leon; Simes, Dina Costa. "Gla Rich Protein is associated with vascular calcification, inflammation and mineral markers in Peritoneal Dialysis Patients". J Clin Med 13 23 (2024): 7429.
    Open access • Published • 10.3390/jcm13237429
  5. Javier Jiménez Herrero; Dina Costa Simes; Rita Abecasis; Paulo Relvas; Erwan Garel; Paula Ventura Martins; Rui Santos. "Monitoring invasive macroalgae in southern Portugal: drivers and citizen science contribution". Frontiers in Environmental Science (2023): http://dx.doi.org/10.3389/fenvs.2023.1324600.
    10.3389/fenvs.2023.1324600
  6. Ezequiel Pinto; Carla Viegas; Paula Ventura Martins; Tânia Nascimento; Leon Schurgers; Dina Simes. "New Food Frequency Questionnaire to Estimate Vitamin K Intake in a Mediterranean Population". Nutrients (2023): https://doi.org/10.3390/nu15133012.
    10.3390/nu15133012
  7. Catarina Marreiros; Carla Viegas; Dina Simes. "Targeting a Silent Disease: Vascular Calcification in Chronic Kidney Disease". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms232416114.
    10.3390/ijms232416114
  8. Mélanie Silva; Farah Kamberovic; Sisay Tesema Uota; Ismael-Mohammed Kovan; Carla S. B. Viegas; Dina C. Simes; Katkam N. Gangadhar; João Varela; Luísa Barreira. "Microalgae as Potential Sources of Bioactive Compounds for Functional Foods and Pharmaceuticals". Applied Sciences (2022): https://doi.org/10.3390/app12125877.
    10.3390/app12125877
  9. Carla S. B. Viegas; Nuna Araújo; Joana Carreira; Jorge Filipe Pontes; Anjos L. Macedo; Maurícia Vinhas; Ana S. Moreira; et al. "Nanoencapsulation of Gla-Rich Protein (GRP) as a Novel Approach to Target Inflammation". International Journal of Molecular Sciences (2022): https://www.mdpi.com/1422-0067/23/9/4813.
    10.3390/ijms23094813
  10. Silva, Ana P.; Viegas, Carla S. B.; Guilherme, Patrícia; Tavares, Nelson; Dias, Carolina; Rato, Fátima; Santos, Nélio; et al. "Gla-Rich Protein, Magnesium and Phosphate Associate with Mitral and Aortic Valves Calcification in Diabetic Patients with Moderate CKD". Diagnostics 12 2 (2022): 496. http://dx.doi.org/10.3390/diagnostics12020496.
    Open access • 10.3390/diagnostics12020496
  11. Brancaccio, Mariarita; Milito, Alfonsina; Viegas, Carla Alexandra; Palumbo, Anna; Simes, Dina Costa; Castellano, Immacolata. "First evidence of dermo-protective activity of marine sulfur-containing histidine compounds". Free Radical Biology and Medicine (2022): https://publons.com/wos-op/publon/55758775/.
    10.1016/J.FREERADBIOMED.2022.09.017
  12. Araújo N; Viegas C; Perrolas I; Costa R; Magalhães J; Blanco F; Ramos A; et al. "Amentadione is a new modulating agent for osteoarthritis in an ex-vivo co-culture preclinical assay". Annals of medicine (2021): http://europepmc.org/abstract/PMC/PMC7888949.
  13. Viegas C; Edelweiss E; Schneider J; Schaeffer-Reiss C; Poterszman A; Rafael M; Araújo N; et al. "Use of an innovative system and nanotechnology-based strategy for therapeutic applications of Gla-rich protein (GRP)". Annals of medicine (2021): http://europepmc.org/abstract/PMC/PMC7888969.
  14. Araujo, Nuna; Viegas, Carla; Pontes, Jorge F.; Marreiros, Catarina; Raimundo, Pedro; Macedo, Anjos L.; de Matos, Antonio Alves; et al. "Nanoencapsulation as a novel delivery approach for therapeutic applications of gla-rich protein (GRP)". Annals of Medicine (2021): https://publons.com/wos-op/publon/50955440/.
    10.1080/07853890.2021.1896900
  15. Nuna Araújo; Carla S. B. Viegas; Eva Zubía; Joana Magalhães; Acácio Ramos; Maria M. Carvalho; Henrique Cruz; et al. "Amentadione from the Alga Cystoseira usneoides as a Novel Osteoarthritis Protective Agent in an Ex Vivo Co-Culture OA Model". Marine Drugs (2020): https://www.mdpi.com/1660-3397/18/12/624.
    Open access • 10.3390/md18120624
  16. SIMES DC. "A relação entre a doença renal crónica e complicações cardiovasculares. Será a proteina GRP a solução?". UALGORITMO A ciencia trocada por miudos. 2 6 (2020): 31-34. https://ualgoritmo.wixsite.com/website/c%C3%B3pia-u2-a2-5.
    Published
  17. Viegas, Carla; Silva, Ana; Macedo, Ana; Mendes, Filipa; Guilherme, Patrícia; Tavares, Nelson; Dias, Carolina; et al. "GLA-RICH PROTEIN (GRP) AS AN EARLY AND NOVEL MARKER ASSOCIATED WITH VASCULAR CALCIFICATION AND CKD-MINERAL AND BONE DISORDER (MBD) IN DIABETIC PATIENTS WITH CKD: A PILOT COHORT STUDY". Nephrology Dialysis Transplantation 35 Supplement (2020): http://dx.doi.org/10.1093/ndt/gfaa143.p0873.
    10.1093/ndt/gfaa143.p0873
  18. Ana P Silva; Carla SB Viegas; Filipa Mendes; Ana Macedo; Patrícia Guilherme; Nelson Tavares; Carolina Dias; et al. "Gla-Rich Protein (GRP) as an Early and Novel Marker of Vascular Calcification and Kidney Dysfunction in Diabetic Patients with CKD: A Pilot Cross-Sectional Study". Journal of Clinical Medicine (2020): https://www.mdpi.com/2077-0383/9/3/635.
    10.3390/jcm9030635
  19. Pedrosa, Rui; P. Gaudêncio, Susana; Vasconcelos, Vitor. "Anti-inflammatory activity of microalgae-derived bioactives with potential dermoprotective applications". Marine Drugs 18 1 (2020): 40. http://dx.doi.org/10.3390/md18010040.
    10.3390/md18010040
  20. Pedrosa, Rui; P. Gaudêncio, Susana; Vasconcelos, Vitor. "AMENTADIONE, A MERODITERPENOIDE FROM BROWN ALGAE WITH CAPACITY OF MODULATING OSTEOARTHRITIC RESPONSES, IN A CLOSE-TO-IN-VIVO OA MODEL". Marine Drugs 18 1 (2020): 40. http://dx.doi.org/10.3390/md18010040.
    10.3390/md18010040
  21. Dina C. Simes; Carla S. B. Viegas; Nuna Araújo; Catarina Marreiros. "Vitamin K as a Diet Supplement with Impact in Human Health: Current Evidence in Age-Related Diseases". Nutrients 12 1 (2020): 138-138. https://doi.org/10.3390/nu12010138.
    10.3390/nu12010138
  22. Marreiros, Catarina; Ismael, Kovan; Viegas, Carla; Araujo, Nuna; Andrade, Miguel; Rosa, Bruno; Lima, Rui; et al. "Anti-Inflammatory Activity of Microalgae-Derived Bioactives with Potential Dermoprotective Apllications". Marine Drugs (2020): https://publons.com/publon/32337057/.
  23. Araujo, Nuna; Viegas, Carla; Perrolas, Ines; Costa, Ruben; Marreiros, Catarina; Magalhaes, Joana; Blanco, Francisco; et al. "Amentadione, a Meroditerpenoide from Brown Algae with Capacity of Modulating Osteoarthritic Responses, in a Close-to-In-Vivo OA Model". Marine Drugs (2020): https://publons.com/publon/32337056/.
  24. Viegas, Carla; Silva, Ana; Macedo, Ana; Mendes, Filipa; Guilherme, Patricia; Tavares, Nelson; Dias, Carolina; et al. "GLA-RICH PROTEIN (GRP) AS AN EARLY AND NOVEL MARKER ASSOCIATED WITH VASCULAR CALCIFICATION AND CKD-MINERAL AND BONE DISORDER (MBD) IN DIABETIC PATIENTS WITH CKD: A PILOT COHORT STUDY". Nephrology Dialysis Transplantation (2020): https://publons.com/publon/44427078/.
  25. Dina C. Simes; Carla S. B. Viegas; Nuna Araújo; Catarina Marreiros. "Vitamin K as a Powerful Micronutrient in Aging and Age-Related Diseases: Pros and Cons from Clinical Studies". International Journal of Molecular Sciences 20 17 (2019): 4150-4150. https://doi.org/10.3390/ijms20174150.
    10.3390/ijms20174150
  26. Viegas, Carla; Araújo, Nuna; Marreiros, Catarina; Simes, Dina. "The interplay between mineral metabolism, vascular calcification and inflammation in Chronic Kidney Disease (CKD): challenging old concepts with new facts". Aging 11 12 (2019): 4274-4299. http://dx.doi.org/10.18632/aging.102046.
    10.18632/aging.102046
  27. Viegas, Carla; Edelweiss, Evelina; Schneider, Justine; Schaeffer-Reiss, Christine; Poterszman, Arnaud; Rafael, Marta; Araújo, Nuna; et al. "Use of an innovative system and nanotechnology-based strategy for therapeutic applications of Gla-rich protein (GRP)". Annals of Medicine 51 sup1 (2019): 38-38. http://dx.doi.org/10.1080/07853890.2018.1561804.
    10.1080/07853890.2018.1561804
  28. Viegas, C.S.B.; Simes, D.C.. "A dual role for GRP in cardiovascular disease". Aging 11 5 (2019): 1323-1324. http://www.scopus.com/inward/record.url?eid=2-s2.0-85062969748&partnerID=MN8TOARS.
    10.18632/aging.101851
  29. Silva, Ana Paula; Viegas, Carla; Simes, Dina; Mendes, Filipa; Tavares, Nelson; Rato, Fatima; Santos, Nelio; Neves, Pedro. "SP430GLA-RICH PROTEIN AS A NOVEL MARKER FOR CALCIFICATIONS IN DIABETIC PATIENTS WITH CKD". Nephrology Dialysis Transplantation 33 suppl_1 (2018): i493-i493. http://dx.doi.org/10.1093/ndt/gfy104.sp430.
    10.1093/ndt/gfy104.sp430
  30. Viegas, C.S.B.; Santos, L.; Macedo, A.L.; Matos, A.A.; Silva, A.P.; Neves, P.L.; Staes, A.; et al. "Chronic kidney disease circulating calciprotein particles and extracellular vesicles promote vascular calcification: A role for GRP (Gla-Rich Protein)". Arteriosclerosis, Thrombosis, and Vascular Biology 38 3 (2018): 575-587. http://www.scopus.com/inward/record.url?eid=2-s2.0-85046012631&partnerID=MN8TOARS.
    10.1161/ATVBAHA.117.310578
  31. Willems, B.A.; Furmanik, M.; Caron, M.M.J.; Chatrou, M.L.L.; Kusters, D.H.M.; Welting, T.J.M.; Stock, M.; et al. "Ucma/GRP inhibits phosphate-induced vascular smooth muscle cell calcification via SMAD-dependent BMP signalling". Scientific Reports 8 1 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85044291781&partnerID=MN8TOARS.
    10.1038/s41598-018-23353-y
  32. Viegas, Carla S. B.; Macedo, Anjos L.; Matos, Antonio A.; Silva, Ana P.; Neves, Pedro L.; Vermeer, Cees; Schurgers, Leon; Simes, Dina C.. "Gla-rich protein, a vitamin K-dependent protein involved in inflammation and calcification-related diseases". Annals of Medicine (2018): https://publons.com/publon/18514686/.
  33. Silva, Ana Paula; Viegas, Carla; Simes, Dina; Mendes, Filipa; Tavares, Nelson; Rato, Fatima; Santos, Nelio; Neves, Pedro. "GLA-RICH PROTEIN AS A NOVEL MARKER FOR CALCIFICATIONS IN DIABETIC PATIENTS WITH CKD". Nephrology Dialysis Transplantation (2018): https://publons.com/publon/18514687/.
  34. Viegas CSB; Costa RM; Santos L; Videira PA; Silva Z; Araújo N; Macedo AL; et al. "Gla-rich protein function as an anti-inflammatory agent in monocytes/macrophages: Implications for calcification-related chronic inflammatory diseases.". PLOS ONE 12 5 (2017): e0177829. http://europepmc.org/abstract/med/28542410.
    10.1371/journal.pone.0177829
  35. Viegas, Carla; Santos, Lucia; Macedo, Anjos; Morais, Rute; Silva, Ana; Neves, Pedro; Matos, Antonio; Vermeer, Cees; Simes, Dina. "CIRCULATING CALCIPROTEIN PARTICLES AND EXTRACELLULAR VESICLES AS NOVEL PLAYERS IN CHRONIC KIDNEY DISEASE VASCULAR CALCIFICATION. A ROLE FOR GLA-RICH PROTEIN". Nephrology Dialysis Transplantation (2017): https://publons.com/publon/28689989/.
  36. Morais R; Viegas CS; Simes DC; Matos AP; Macedo AL. "Application of TEM techniques for the study of vascular calcification: Monitoring extracellular vesicles and nanogold immunodetection of fetuin-A, GRP, and CD9.". (2017): http://europepmc.org/abstract/med/28230494.
    10.1080/01913123.2016.1272670
  37. Viegas CS; Macedo AL; Morais R; Santos L; Matos AP; Silva AP; Neves P; Simes DC. "Dysregulated fetuin-mineral complexes are linked to vascular calcification in chronic kidney disease: The role of Gla-rich protein.". (2017): http://europepmc.org/abstract/med/28230466.
    10.1080/01913123.2016.1269490
  38. Viegas, C.S.B.; Rafael, M.S.; Enriquez, J.L.; Teixeira, A.; Vitorino, R.; Luís, I.M.; Costa, R.M.; et al. "Gla-rich protein acts as a calcification inhibitor in the human cardiovascular system". Arteriosclerosis, Thrombosis, and Vascular Biology 35 2 (2016): 399-408. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922014561&partnerID=MN8TOARS.
    10.1161/ATVBAHA.114.304823
  39. MacEdo, A.L.; Viegas, C.S.B.; Matos, A.P.A.; Simes, D.C.. "Extracellular vesicles and circulating fetuin-mineral complexes in vascular calcification; Studies by em techniques". Microscopy and Microanalysis 22 (2016): 16-17. http://www.scopus.com/inward/record.url?eid=2-s2.0-85014510834&partnerID=MN8TOARS.
    10.1017/S1431927616000271
  40. Simes, Dina. "New Perspectives for the Nutritional Value of Vitamin K in Human Health". J Nutr Disorders Ther (2016): http://dx.doi.org/10.4172/2161-0509.1000192.
    doi.org/10.4172/2161-0509.1000192
  41. Simes, Dina. "Gla-rich Protein (GRP): A New Player in the Burden of Vascular Calcification". J Cardiovasc Dis Diagn (2016):
    doi: 10.4172/2329-9517.1000245
  42. Cavaco, S.; Viegas, C.S.B.; Rafael, M.S.; Ramos, A.; Magalhães, J.; Blanco, F.J.; Vermeer, C.; Simes, D.C.. "Gla-rich protein is involved in the cross-talk between calcification and inflammation in osteoarthritis". Cellular and Molecular Life Sciences 73 5 (2016): 1051-1065. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957428368&partnerID=MN8TOARS.
    10.1007/s00018-015-2033-9
  43. Richard, N.; Engrola, S.; Palma, P.S.; Simes, D.C.; Conceição, L.E.C.; Richard N; Engrola S; et al. "Assessment of protein digestive capacity and metabolic utilisation during ontogeny of Senegalese sole larvae: A tracer study using in vivo produced radiolabelled polypeptide fractions". Aquaculture 441 (2015): 35-44. http://www.scopus.com/inward/record.url?eid=2-s2.0-84923271202&partnerID=MN8TOARS.
    10.1016/j.aquaculture.2015.02.003
  44. Viegas, C.; Rafael, M.; Enriquez, J.; Teixeira, A.; Vitorino, R.; Costa, R.; Santos, L.; et al. "GLA-RICH PROTEIN (GRP) IS A NEW PLAYER IN MINERALIZATION-COMPETENCE OF EXTRACELLULAR VESICLES INVOLVED IN VASCULAR CALCIFICATION". Journal of Vascular Research (2015): https://publons.com/publon/8974168/.
  45. Rafael, Marta S.; Cavaco, Sofia; Viegas, Carla S. B.; Santos, Sofia; Ramos, Acácio; Willems, Brecht A. G.; Herfs, Marjolein; et al. "Insights into the association of Gla-rich protein and osteoarthritis, novel splice variants and ¿-carboxylation status". Molecular Nutrition & Food Research 58 8 (2014): 1636-1646. http://dx.doi.org/10.1002/mnfr.201300941.
    10.1002/mnfr.201300941
  46. Viegas, C.S.B.; Herfs, M.; Rafael, M.S.; Enriquez, J.L.; Teixeira, A.; Luís, I.M.; Van 'T Hoofd, C.M.R.; et al. "Gla-rich protein is a potential new vitamin K target in cancer: Evidences for a direct GRP-mineral interaction". BioMed Research International 2014 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84902129958&partnerID=MN8TOARS.
    10.1155/2014/340216
  47. Cavaco, Sofia; Williamson, Matthew K.; Rosa, Joana; Roberto, Vânia; Cordeiro, Odete; Price, Paul A.; Leonor Cancela, M.; Laizé, Vincent; Simes, Dina C.. "Teleost fish osteocalcin 1 and 2 share the ability to bind the calcium mineral phase". Fish Physiology and Biochemistry 40 3 (2013): 731-738. http://dx.doi.org/10.1007/s10695-013-9880-9.
    10.1007/s10695-013-9880-9
  48. Viegas, C.S.B.; Simes, D.C.; Williamson, M.K.; Cavaco, S.; Laizé, V.; Price, P.A.; Cancela, M.L.. "Sturgeon osteocalcin shares structural features with matrix Gla protein: Evolutionary relationship and functional implications". Journal of Biological Chemistry 288 39 (2013): 27801-27811. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884788467&partnerID=MN8TOARS.
    10.1074/jbc.M113.450213
  49. Carla S. B. Viegas; Dina C. Simes; Matthew K. Williamson; Sofia Cavaco; Vincent Laizé; Paul A. Price; M. Leonor Cancela. "Sturgeon Osteocalcin Shares Structural Features with Matrix Gla Protein". Journal of Biological Chemistry (2013): https://publons.com/publon/8735250/.
    10.1074/JBC.M113.450213
  50. Willems, B. A. G.; Chatrou, M. L. L.; Kusters, H. M.; Theuwissen, E.; Simes, D.; Vermeer, C.; Reutelingsperger, C. P. M.; Schurgers, L. J.. "GRP/Ucma: a novel member of the class of vitamin K-dependent proteins is involved in osteochondrogenic transdifferentiation of vascular smooth muscle cells". Journal of Thrombosis and Haemostasis (2013): https://publons.com/publon/18514688/.
  51. Cavaco, S.I.; Viegas, C.B.; Marta, R.; Acácio, R.; Silva, J.; Morera, J.L.; Teixeira, A.; et al. "Gla rich protein (grp) is associated to osteoarthritis being highly accumulated in the joint tissues and synovial fluid". Osteoarthritis and Cartilage 20 (2012): S90-S91. http://dx.doi.org/10.1016/j.joca.2012.02.090.
    10.1016/j.joca.2012.02.090
  52. Oliveira, D.V.; Silva, T.S.; Cordeiro, O.D.; Cavaco, S.I.; Simes, D.C.. "Identification of proteins with potential osteogenic activity present in the water-soluble matrix proteins from crassostrea gigas nacre using a proteomic approach". The Scientific World Journal 2012 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84862327983&partnerID=MN8TOARS.
    10.1100/2012/765909
  53. Cavaco, S. I.; Viegas, C.; Cordeiro, O.; Vareilles, M.; Silva, T.; Palma, P.; Simes, D.. "Identification and characterization of GRP in articular cartilage and synovial fluid using a proteomic-based approach". Bone (2011): https://publons.com/publon/9358225/.
    10.1016/J.BONE.2011.03.652
  54. Viegas, C. S. B.; Conceição, N.; Fazenda, C.; Simes, D. C.; Cancela, M. L.. "Expression of Gla-rich protein (GRP) in newly developed cartilage-derived cell cultures from sturgeon (Acipenser naccarii)". Journal of Applied Ichthyology 26 2 (2010): 214-218. http://dx.doi.org/10.1111/j.1439-0426.2010.01408.x.
    10.1111/j.1439-0426.2010.01408.x
  55. Roberto, Vânia P.; Cavaco, Sofia; Viegas, Carla S.B.; Simes, Dina C.; Ortiz-Delgado, Juan-Bosco; Sarasquete, M. Carmen; Gavaia, Paulo J.; Cancela, M. Leonor. "Matrix Gla protein in turbot (Scophthalmus maximus): Gene expression analysis and identification of sites of protein accumulation". Aquaculture 294 3-4 (2009): 202-211. http://dx.doi.org/10.1016/j.aquaculture.2009.06.020.
    10.1016/j.aquaculture.2009.06.020
  56. Viegas, C.S.B.; Cavaco, S.; Neves, P.L.; Ferreira, A.; João, A.; Williamson, M.K.; Price, P.A.; Cancela, M.L.; Simes, D.C.. "Gla-rich protein is a novel vitamin K-dependent protein present in serum that accumulates at sites of pathological calcifications". American Journal of Pathology 175 6 (2009): 2288-2298. http://www.scopus.com/inward/record.url?eid=2-s2.0-73549121071&partnerID=MN8TOARS.
    Open access • 10.2353/ajpath.2009.090474
  57. Dina C. Simes; Carla B. Viegas; Matthew K. Williamson; Paul A. Price; Leonor Cancela. "Purification of matrix Gla protein and osteocalcin from the adriatic sturgeon (Acipencer naccarii), an Ancient bony fish with a cartilaginous endoskeleton". Bone 42 (2008): S65-S65. http://dx.doi.org/10.1016/j.bone.2007.12.116.
    10.1016/j.bone.2007.12.116
  58. Viegas, C.S.B.; Simes, D.C.; Laizé, V.; Williamson, M.K.; Price, P.A.; Cancela, M.L.; Viegas, C. S. B.; et al. "Gla-rich protein (GRP), a new vitamin K-dependent protein identified from sturgeon cartilage and highly conserved in vertebrates". Journal of Biological Chemistry 283 52 (2008): 36655-36664. http://www.scopus.com/inward/record.url?eid=2-s2.0-61349170719&partnerID=MN8TOARS.
    10.1074/jbc.M802761200
  59. Gavaia, P.J.; Simes, D.C.; Ortiz-Delgado, J.B.; Viegas, C.S.B.; Pinto, J.P.; Kelsh, R.N.; Sarasquete, M.C.; et al. "Osteocalcin and matrix Gla protein in zebrafish (Danio rerio) and Senegal sole (Solea senegalensis): Comparative gene and protein expression during larval development through adulthood". Gene Expression Patterns 6 6 (2006): 637-652. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646862665&partnerID=MN8TOARS.
    10.1016/j.modgep.2005.11.010
  60. Ortiz-Delgado, J.B.; Simes, D.C.; Viegas, C.S.B.; Schaff, B.J.; Sarasquete, C.; Cancela, M.L.; J. B. Ortiz-Delgado; et al. "Cloning of matrix Gla protein in a marine cartilaginous fish, Prionace glauca: Preferential protein accumulation in skeletal and vascular systems". Histochemistry and Cell Biology 126 1 (2006): 89-101. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745063198&partnerID=MN8TOARS.
    10.1007/s00418-005-0125-6
  61. Ortiz-Delgado, J. B.; Simes, D. C.; Gavaia, P.; Sarasquete, C.; Cancela, M. L.. "Osteocalcin and matrix GLA protein in developing teleost teeth: identification of sites of mRNA and protein accumulation at single cell resolution". Histochemistry and Cell Biology 124 2 (2005): 123-130. http://dx.doi.org/10.1007/s00418-005-0015-y.
    10.1007/s00418-005-0015-y
  62. Frazão, Carlos; Simes, Dina C.; Coelho, Ricardo; Alves, Dora; Williamson, Matthew K.; Price, Paul A.; Cancela, M. Leonor; Carrondo, Maria A.. "Structural Evidence of a Fourth Gla Residue in Fish Osteocalcin:  Biological Implications". Biochemistry 44 4 (2005): 1234-1242. http://dx.doi.org/10.1021/bi048336z.
    10.1021/bi048336z
  63. Dina Simes. "Constitutive expression of Sparus aurata osteocalcin in a chondrocytic-like (VSA13) and osteoblastic-like cell line (VSA16): Effect on mineralization rate and levels of calcification-related gene expression". Bone (2005): https://publons.com/publon/13755101/.
  64. Paulo Gavaia. "Osteocalcin and matrix Gla protein in developing teleost teeth. Identification of sites of expression and protein accumulation". Bone (2005): https://publons.com/publon/565424/.
  65. Simes, D. C.; Williamson, M. K.; Schaff, B. J.; Gavaia, P. J.; Ingleton, P. M.; Price, P. A.; Cancela, M. L.. "Characterization of Osteocalcin (BGP) and Matrix Gla Protein (MGP) Fish Specific Antibodies: Validation for Immunodetection Studies in Lower Vertebrates". Calcified Tissue International 74 2 (2004): 170-180. http://dx.doi.org/10.1007/s00223-003-0079-4.
    10.1007/s00223-003-0079-4
  66. Pessoa, J.C.; Calhorda, M.J.; Cavaco, I.; Costa, P.J.; Correia, I.; Costa, D.; Vilas-Boas, L.F.; et al. "N-Salicylideneamino acidato complexes of oxovanadium(IV). the cysteine and penicillamine complexes". Dalton Transactions 18 (2004): 2855-2866. http://www.scopus.com/inward/record.url?eid=2-s2.0-7044286414&partnerID=MN8TOARS.
    10.1039/b404305g
  67. Simes, DC; Williamson, MK; Ortiz-Delgado, JB; Viegas, Csb; Price, PA; Cancela, ML. "Purification of Matrix Gla Protein From a Marine Teleost Fish, Argyrosomus regius: Calcified Cartilage and Not Bone as the Primary Site of MGP Accumulation in Fish". Journal of Bone and Mineral Research 18 2 (2003): 244-259. http://dx.doi.org/10.1359/jbmr.2003.18.2.244.
    10.1359/jbmr.2003.18.2.244
  68. Moura, José J. G.; Simes, Dina C.; Bebianno, Maria João; Dina C. Simes; Maria João Bebianno; José J.G. Moura; Simes, D.C.; Bebianno, M.J.; Moura, J.J.G.. "Isolation and characterisation of metallothionein from the clam Ruditapes decussatus". Aquatic Toxicology 63 3 (2003): 307-318. http://hdl.handle.net/10362/1667.
    10.1016/s0166-445x(02)00185-6
  69. Viegas, C.S.B.; Pinto, J.P.; Conceição, N.; Simes, D.C.; Cancela, M.L.. "Cloning and characterization of the cDNA and gene encoding Xenopus laevis osteocalcin". Gene 289 1-2 (2002): 97-107. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036572833&partnerID=MN8TOARS.
    10.1016/S0378-1119(02)00480-8
  70. Simes, Dina; Gavaia, Paulo J.; Ortiz-Delgado, J. B.; Pinto, J. P.; Cancela, Leonor; Paulo Gavaia. "Characterization of specific antibodies for fish osteocalcin and its usefulness to investigate osteocalcin tissue distribution in lower vertebrates.". Bone (2001): http://hdl.handle.net/10400.1/4426.
  71. Pessoa, J.C.; Cavaco, I.; Correia, I.; Costa, D.; Henriques, R.T.; Gillard, R.D.. "Preparation and characterisation of new oxovanadium(IV) Schiff base complexes derived from salicylaldehyde and simple dipeptides". Inorganica Chimica Acta 305 1 (2000): 7-13. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034647419&partnerID=MN8TOARS.
    10.1016/S0020-1693(00)00102-X
  72. Bebianno, M.J.; Serafim, M.A.; Simes, D.; M. J. Bebianno; M. A. Serafim; Dina Simes; Bebianno, MJ; Serafim, MA; Simes, Dina. "Metallothioneins in the clam Ruditapes decussatus: An overview". Analusis 28 5 (2000): 386-390. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034209326&partnerID=MN8TOARS.
    10.1051/ANALUSIS:2000280386
  73. Dina Simes. "Expression of matrix Gla protein (MGP) in fish and amphibian: A model system to study the evolution of MGP function.". Journal of Bone and Mineral Research (2000): https://publons.com/publon/13755133/.
  74. Cavaco, I.; Pessoa, J.C.; Costa, D.; Duarte, M.T.; Gillard, R.D.; Matias, P.. "N-salicylideneamino acidate complexes of oxovanadium(IV). Part 1. Crystal and molecular structures and spectroscopic properties". Journal of the Chemical Society, Dalton Transactions 2 (1994): 149-157. http://www.scopus.com/inward/record.url?eid=2-s2.0-37049081957&partnerID=MN8TOARS.
    10.1039/DT9940000149
  75. Roseiro JC; Costa DC; Collaco MTA. "Batch and fed-batch cultivation of Xanthomonas campestris in carob extracts.". Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire (1992): http://europepmc.org/abstract/AGR/IND93002142.
  76. Roseirol, J.C.; Costa, D.C.; Collaço, M.T.A.. "Batch and fed-batch cultivation of Xanthomonas campestris in carob extracts". LWT - Food Science and Technology 25 3 (1992): 289-293. http://www.scopus.com/inward/record.url?eid=2-s2.0-0344883326&partnerID=MN8TOARS.
Newspaper article
  1. SIMES DC. "A relação entre a doença renal crónica e complicações cardiovasculares-será a proteína GRP a solução?", Ualgoritmo, 2020, https://ualgoritmo.wixsite.com/website/c%C3%B3pia-u2-a2-5.
Preprint
  1. Ezequiel Pinto; Carla Viegas; Paula Ventura Martins; Tânia Nascimento; Leon Schurgers; Dina Simes. "New Food-Frequency Questionnaire to Estimate Vitamin K intake in a Mediterranean Population". 2023. https://doi.org/10.20944/preprints202306.1831.v1.
    10.20944/preprints202306.1831.v1
Thesis / Dissertation
  1. Marreiros, Catarina Isabel Lousada. "Clinical application of extracellular vesicles in vascular calcification". Master, 2017. http://hdl.handle.net/10400.1/10566.
  2. Cavaco, Sofia Isabel Franco. "Studies towards unveiling the association of Gla-rich protein with osteoarthritis". PhD, 2017. http://hdl.handle.net/10400.1/10803.
  3. Perrolas, Inês Madeira. "Bioactive marine compounds as novel therapeutics in osteoarthritis". Master, 2017. http://hdl.handle.net/10400.1/10052.
  4. Pereira, Carla Margarida da Silva. "The role of vitamin K in osteoarthritis". Master, 2016. http://hdl.handle.net/10400.1/9885.
  5. Santos, Lúcia Alexandra Rosa dos. "Interaction studies of Gla-rich protein with bone morphogenetic proteins". Master, 2014. http://hdl.handle.net/10400.1/7922.
  6. Maria, Vera Lúcia Teixeira de Jesus. "Produção e purificação da proteína rica em gla (grp) humana recombinante". Master, 2011. http://hdl.handle.net/10400.1/3790.
  7. Simes, Dina Cristina F. R. Costa. "Purification, biochemical characterization and localization at single cell resolution of Matrix Gla Protein (MGP) and Bone Gla Protein (BGP) in the teleost fish Argyrosomus regius". PhD, 2002. http://hdl.handle.net/10400.1/8458.
Website
  1. Dina Simes. Corresponding author: Dina Simes. Plataforma digital Algas na praia. 2021. https://form.jotform.com/212044035885352.

Intellectual property

Patent
  1. Leonor Cancela; Simes, Dina; S B Viegas, Carla. 2010. "A gammacarboxyglutamate-rich protein, methods and assays for its detection, purification and quantification and uses thereof".
    Expired
  2. Simes, Dina; Viegas, CSB; Cancela, M.L.. 2009. "A GAMMACARBOXYGLUTAMATE-RICH PROTEIN, METHODS AND ASSAYS FOR ITS DETECTION, PURIFICATION AND QUANTIFICATION AND USES THEREOF (PCT/PT2009/000046)".
    Pending

Other

Other output
  1. Guest Editor Special Issue "Vitamin K and Vitamin K-Dependent Proteins in Homeostasis and Pathology". A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".. 2021. SIMES DC. https://www.mdpi.com/journal/ijms/special_issues/Vitamin_K-Dependent_Proteins#info.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/12/03 ALGARED+: Old and new microalgae for novel bioactivities. ALGAEUROPE 2019
ALGAEUROPE 2019 (Paris, France)
2019/11/22 Round table “Aplicações da biomassa de algas Workshop ALGAS – Investigação, inovação, sustentabilidade e estímulo à bioeconomia circular.
AlgaRed+ (Faro, Portugal)
2019/10/18 New advances on Gla Rich Protein (GRP) as a clinical utility biomarker for cardiovascular risk assessment in chronic kidney disease Sinal 2019-10th Meeting on signal Transduction,
10th Meeting on signal Transduction (olhão)
2019/09/16 Treating old diseases with new bioactive compounds obtained from marine resources Seminário Biotecnologia azul, 1 ciclo de gestão marinha e costeira,
Universidade do Algarve (fa, Portugal)
2019/09/01 Amentadione, a meroditerpenoide from brown algae with capacity of modulating osteoarthritic responses, in a close-to-in-vivo OA model. Joint XVI International Symposium on Marine Natural Products and XI European Conference on Marine Natural Products,
XVI MANAPRO & XI ECMNP (Peniche, Portugal)
2019/06/02 Nanoencapsulation as a novel delivery approach for therapeutic applications of gla-rich protein (GRP). 4th congress of CiiEM-Health, Well-Being and Ageing in the 21st Century
CiiEM (Monte da caparica, Portugal)
2019/03/26 Anti-inflammatory and dermoprotective activity of a selection of microalgae extracts Workshop AlgaRed+, I seminário Projeto ALGARED+ Novas microalgas, novas aplicações
Universidade do Algarve (Faro, Portugal)
2018/11/08 Amentadione from the alga Cystoseira Usneoides - potential application in osteoarthritis therapeutics Seminário Biotecnologia Azul, 1 ciclo Gestão marinha e Costeira
Universidade do Algarve-FCT (Faro, Portugal)
2018/10/13 Gla-rich Protein (GRP): A new player in the burden of vascular Calcification – clinical implications Núcleo de Biologia Vascular da SPACV
SPACV (Ilhavo, Portugal)
2018/06/20 Amentadione is a new modulating agent for osteoarthritis in an ex-vivo co-culture preclinical assay. 3rd International Congress of CiiEM- Research and Innovation in Human & Health Sciences
CiiEM (Monte da Caparica, Portugal)
2018/06/20 Use of an innovative system and nanotechnology-based strategy for therapeutic applications of Gla-rich protein (GRP). 3rd International Congress of CiiEM- Research and Innovation in Human & Health Sciences
CiiEM (Monte da Caparica, Portugal)
2018/03/22 Gla-Rich Protein como um novo marcador de calcificações vasculares numa população de diabéticos com doença renal crónica. Encontro Renal 2018, XXXII Congresso SPN
Sociedade Portuguesa de Nefrologia (Vilamoura, Portugal)
2017/11/04 Gla-rich Protein (GRP) is a New Therapeutic Target for Chronic Kidney Disease PCS 4th World Congress of Cardiothoracic-renal Diseases “Bridging Basic Research and Clinical Practice
PCS 4th World Congress of Cardiothoracic-renal Diseases (Lisboa, Portugal)
2017/06/28 Unveiling the dual role of Gla-rich protein (GRP) in the crosstalk between inflammation and calcification in pathological processes Seminários CCMAR
CCMAR (Faro, Portugal)
2017/06/11 Gla-rich protein, a vitamin K-dependent protein involved in inflammation and calcification-related diseases 2º Congresso Internacional do CiiEM - Translational Research and Innovation in Human and Health Sciences
CiiEM
2017/06/03 Circulating calciprotein particles and extracellular vesicles as novel players in chronic kidney disease vascular calcification: a role for Gla-rich protein ERA-EDTA 54th Annual Congress
ERA-EDTA (Madrid, Spain)
2016/07/11 Dysregulated fetuin-mineral complexes are linked to vascular calcification in chronic kidney disease: the role of Gla-rich protein Ultrapath XVII, Society for Ultrastructural Pathology
Society for Ultrastructural Pathology (Lisboa, Portugal)
2016/06/08 Exploring the sea for novel drugs to treat old diseases Seminarios CCMAR
CCMAR
2016/05/05 Marine bioactive compounds: testing novel drugs for old desiases IX Xornada Cientifica Terapia Celular e medicina regenerativa
CICA, Campus de Elviña (Coruña)
2016/04/04 In vitro testing of bioactive compounds: a bridge to clinical trials and industrial application EuroMarine Meeting entitled “Exploitation and Legal Aspects on Marine Genetic and Chemical Resources
Institute of Protein Biochemistry, CNR Research Area (Naples, Italy)
2016/02/25 Centre of Marine Sciences (CCMAR) – Central de Serviços e Tecnologia do CCMAR Sessão Transfronteiriça de Divulgação de Serviços I&DT na Área da Saúde
CRIA – Divisão de Empreendedorismo e Transferência de Tecnologia e Escola Superior de Saúde (Faro, Portugal)
2015 New targets for therapeutics in osteoarthritis: Marine compounds and Gla rich proteins 9th SFRR-Africa/4th IAMBR conference. Translational Science and Drug Discovery: Impact on Health, Wellness, Environment and Economics
9th SFRR-Africa/4th IAMBR conference (Mauritius)
2013/07/01 GRP/Ucma: a potential novel vitamin K-dependent protein, involved in osteochondrogenic transdifferentiation of vascular smooth muscle cells. XXIV Congress of the International Society on Thrombosis and haemostasis (ISTH)
INTERNATIONAL SOCIETY ON THROMBOSIS AND HAEMOSTASIS (Amesterdam, Netherlands)
2013/06/29 GRP/Ucma: a potential novel vitamin K-dependent protein, involved in osteochondrogenic transdifferentiation of vascular smooth muscle cells. XXIV Congress of the International Society on Thrombosis and haemostasis (ISTH)
International Society on Thrombosis and haemostasis (Amsterdam, Netherlands)
2012/12/06 O Farmacêutico empreendedor em meio Universitário. Start-ups III Colóquio NECiFarm
NECiFarm (Faro, Portugal)
2011/10/19 Papel de uma nova proteína no processo degenerativo da cartilagem articular: resultados preliminares XXXI Congresso Nacional de Ortopedia e Traumatologia
Congresso Nacional de Ortopedia e Traumatologia (Estoril, Portugal)
2011/07/13 Applications of recombinant proteins Three days course on strategies for recombinant protein production
CCMAR (Faro, Portugal)
2010/10/20 Study of Gla Rich Protein (GRP) and its potential for use as a biomarker of pathological calcification related diseases Sociedade Portuguesa de Biofísica
SPB (Monte da Caparica, Portugal)
2010/03/21 Gla Rich Protein (GRP), A New Biomarker For Ectopic Calcifications? BIT’s 3rd Annual Protein and Peptide Conference
BIT’s (Beijing, China)
2010/01/29 Study of Gla Rich Protein (GRP) function in pathological calcification processes and its potential for use as a biomarker IV SPB Clinical Biochemistry Workshop
SPB (Faro, Portugal)
2009/10/26 Aplicações da análise proteomica 2D na identificação de possiveis biomarcadores para diagnóstico/prognóstico de doenças Seminários CHUAlgarve
CHUAlgarve (Faro, Portugal)
2009/05/27 Fish as model organisms to uncover new Gla proteins of interest for human biology , 27-29 April, Tavira, Portugal (Cancela ML, invited speaker) Workshop - Interdisciplinary Approaches in Fish Skeletal Biology
Universidade do Algarve (Tavira, Portugal)
2008/11/12 Identification of an MGP/OC hybrid gene in Adriatic sturgeon (Acipenser naccarii), representing an ancient form of Osteocalcin. Seminários CCMAR
CCMAR (Faro, Portugal)
2007/05/03 Identification of an MGP/OC hybrid gene in Adriatic sturgeon Acipenser naccarii Seminários Mar e Ambiente
Universidade do Algarve (Faro, Portugal)
2006/05/19 Molecular cloning and regulation of the genes encoding Matrix and Bone Gla proteins from Sturgeon. Studies towards understanding the evolution of their molecular mechanism of action Seminários Mar e Ambiente
Universidade do Algarve (Faro, Portugal)
2005/04/21 Gla Proteins from bone and cartilage: Importance of Anfibious and fish biological models to elucidate the function and evolution of these proteins. 1º Meeting “O Mar e as Ciências da Saúde”
Universidade Nova de Lisboa (fa, Portugal)
2004/12/02 Effect of nacre extracts from the oyster Crassostrea gigas in the mineralization of bone-derived cells from Sparus aurata XIV Biochemistry National Congress
SPB
2003/05/08 Simultaneous detection of Osteocalcin and Matrix Gla Protein in developmental stages of Zebra fish (Danio rerio) 30th European Symposium on Calcified Tissues.
(ROMA, Italy)
2003/05 Acumulación y expresión de proteínas Gla de la matriz en lenguado, Solea senegalensis, y el pez cebra, Danio rerio IX Congreso Nacional de Acuicultura, May, Cadiz, Spain (Gavaia PJ invited speaker)
(Cadiz, Spain)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/04/01 - Current Engineered Extracellular Vesicles (EVs) loaded with Gla-Rich Protein (GRP) as nanotherapeutics for cardiovascular and chronic kidney diseases. 2022.12777.BD
Supervisor
 Programa Doutoral do Departamento de Ciências Biomédicas e de Medicina da Universidade do Algarve (PhD)
Universidade do Algarve, Portugal
2022 - Current Search for novel macroalgae-derived dietary supplements with anti-inflammatory and antioxidant activity.
Supervisor of Benjamin Igbodo,
 Qualidade em Análises (Master)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2021/04/01 - Current Studies towards the establishment of Gla-rich protein as a biomarker for cardiovascular risk assessment. 2020.07476.BD
Supervisor of Catarina Marreiros
 Programa Doutoral do Departamento de Ciências Biomédicas e de Medicina da Universidade do Algarve (PhD)
Universidade do Algarve - Campus de Gambelas, Portugal
2018 - Current Extracellular vesicles in cardiovascular therapeutics.
Supervisor of Emanuela Ciccone
Universidade do Algarve, Portugal
2016/12 - Current Interplay between mineralization and inflammation in vascular calcification and osteoarthritis: extracellular vesicles and marine bioactive compounds as new therapeutic approaches. SFRH/BD/111824/2015
Supervisor of Nuna Claudia Peixoto de Araújo
 Programa Doutoral do Departamento de Ciências Biomédicas e de Medicina da Universidade do Algarve (PhD)
Universidade do Algarve, Portugal
2024/01/15 - 2024/07/31 Exploring Algae for new anti-inflammatory and antioxidant bioactives with potential application in chronic inflammatory diseases
Supervisor
 IMBRSea Master program (Master)
2023/09/09 - 2024/02/02 Exploring Human-derived extracellular vesicles (EVs) loaded with human GRP as new anti-inflammatory nanoformulations
Co-supervisor
 Projeto Cientifico 12 ECTS (Degree)
Universidade do Algarve, Portugal
2023/09/15 - 2024/02/01 EXPLORING VITAMIN K1 AS NOVEL THERAPEUTIC PREVENTION STRATEGY FOR OSTEOARTHRITIS.
Co-supervisor
 Projeto cientifico 12 ECTS (Degree)
Universidade do Algarve, Portugal
2023/09/15 - 2024/02/01 Exploração do potencial de extratos de macroalgas e da Vitamina K como antioxidantes e anti-inflamatórios para novos suplementos alimentares.
Supervisor
 Projeto Cientifico 12 ECTS (Degree)
2021 - 2022/07/01 Marine-derived vitamin K as a natural supplement with anti-inflammatory and vascular protective properties.
Supervisor of Barbara Vieira
 Biologia Molecular e Microbiana (Master)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2021/10/04 - 2022/02/28 Enzyme-Linked Immunosorbent Assay (ELISA) for detection and quantification of specific proteins. .Laboratory methods B 3 ECTS
Supervisor of Mengfei Yuan
Universidade do Algarve, Portugal
2021/07/01 - 2022/02/28 Master fellowship BI_ Projeto 72583 NutriSafe: Explorando um novo e sustentável suplemento alimentar de origem marinha na promoção da longevidade e qualidade de vida em tempos de pandemia” Universidade do Algarve, financiado pelo Fundo Europeu de Desenvolvimento Regional (FEDER) através do Programa Operacional CRESC Algarve 2020, do Portugal2020, 6 months. Titulo:
Supervisor
Universidade do Algarve, Portugal
2021/10/04 - 2022/02/19 Exploração de novos compostos bioativos como agentes anti-inflamatórios e anticalcificantes com potencial aplicação em doenças inflamatórias crónicas (CID). Projeto 12 ECTS
Supervisor of Jessica Martins
 Bioquímica (Other)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2021/10/04 - 2022/02/19 Purification and characterization of human Gla rich protein (GRP) overexpressed in the E.Coli system. PLACEMENT 6 ECTS
Supervisor
 Biologia Molecular e Microbiana (Other)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2021 - 2021/07 Methods for the study of Gla-rich protein (GRP) in vascular calcification and inflammation.
Supervisor of Melissa Fisher
 Biologia (Degree)
Universidade de Aveiro, Portugal
2021/03/09 - 2021/04/16 Madeira, Helena (2021). Estudo do potencial anti-inflamatório cutâneo de novos componentes obtidos a partir de algas marinhas. Modulo de Escolha do Estudante 1 (8 ECTS), Integrated Master in Medicine - UAlg
Supervisor of Helena Madeira
 Medicine (Master)
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2019 - 2020/09/10 Preclinical studies for development and testing of dermocosmetics from marine origin.
Supervisor of Maria Inês Pinho
 Mestrado integrado em ciencias farmaceuticas (Master)
Universidade do Algarve, Portugal
2019 - 2019 Extraction of anti-inflammatory drugs form Microalgae.
Co-supervisor of Kovan Ismael
WATER AND COASTAL MANAGEMENT - ERASMUS MUNDUS (Master)
Universidade do Algarve, Portugal
2019 - 2019 Gla-rich protein, a marker for calcification propensity in diabetic with chronic kidney disease. Modulo de escolha do Estudante, Mestrado Integrado em Medicina , UAlg
Supervisor of Carolina Dias
Universidade do Algarve, Portugal
2019 - 2019 Testing the therapeutic potential of Gla Rich Protein-chitosan-tripolyphosphate nanoparticles for osteoarthritis using an ex-vivo co-culture preclinical assay.
Supervisor of António Magalhães
 Modulo escolha do Estudante, Departamento de Ciências Biomédicas e medicina (Scientific initiation)
Universidade do Algarve, Portugal
2018 - 2018 Study the role of GRP produced by inflammatory cells in mediating VSMCs inflammation
Supervisor of Joana Correia
Universidade do Algarve, Portugal
2018 - 2018 Study the association of Gla-rich protein (GRP) with urinary extracellular vesicles (EVs) and chronic kidney disease (CKD).
Supervisor of Larissa Almeida
Universidade do Algarve, Portugal
2018 - 2018 Testing the anti-inflammatory potential of Gla Rich Protein nanoparticles for its use in therapeutics.
Supervisor of Pedro Raimundo
Universidade do Algarve, Portugal
2013/01/01 - 2017/03/03 The application of 2D-DIGE proteomics to human articular cartilage. A new approach for the identification of osteoarthritis biomarkers. SFRH/BD/60867/2009
Supervisor
 Ciências Biológicas (PhD)
Universidade do Algarve, Portugal
2017 - 2017 Bioactive marine compounds as novel therapeutics in osteoarthritis
Supervisor of Inês Madeira Perrolas
 Ciências Biomédicas (Master)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2017 - 2017 Clinical application of extracellular vesicles in vascular calcification
Supervisor of Catarina Isabel Lousada Marreiros
 Ciências Farmacêuticas (Master)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2017 - 2017 In vitro studies to determine the role of fetuin-mineral complex in the calcification stress in CKD. Subject
Supervisor of Vando Emanuel
Universidade do Algarve, Portugal
2017 - 2017 Can we use the tissues obtained from OA patients to set up a 3D in vitro model for the study of osteoarthritis?
Supervisor of Cláudia Martins
Universidade do Algarve, Portugal
2013 - 2017 STUDIES TOWARDS UNVEILING THE ASSOCIATION OF GLA-RICH PROTEIN WITH OSTEOARTHRITIS
Supervisor of Sofia Isabel Franco Cavaco
 Ciências Biológicas (PhD)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2016 - 2016 The role of vitamin K in osteoarthritis
Supervisor of Carla Margarida da Silva Pereira
 Ciências Farmacêuticas (Master)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2015 - 2015 Cultivation techniques of THP-1 cell line, isolation of extracellular vesicles and characterization of its components.
Supervisor of Kevin Astorga
 Biologia (Scientific initiation)
2015 - 2015 Gla-Rich-Protein (GRP): a Novel Vitamin K-Dependent Protein, with potential to interfere with the dynamics of basic-calcium phosphate (BCP) crystals formation
Supervisor of Kevin Astorga
 Bioquímica (Scientific initiation)
Universidade do Algarve, Portugal
2014 - 2014 Interaction studies of Gla-rich protein with bone morphogenetic proteins
Supervisor of Lúcia Alexandra Rosa dos Santos
 Ciências Biomédicas (Master)
Universidade do Algarve, Portugal
2014 - 2014 Calcified aortic valve and aortic rings: what’s the role of Gla-rich protein?
Supervisor of Ricardo Filipe
 Modulo escolha do Estudante, Departmento de Medicina (Scientific initiation)
2013 - 2013 STUDY OF THE ASSOCIATION OF GLA RICH PROTEIN (GRP) TO HUMAN BLOOD CELLS
Supervisor of RÚBEN MARTINS DA COSTA
 Ciências Biomédicas (Master)
Universidade do Algarve, Portugal
2013 - 2013 GRP gene expression in different mouse tissues
Supervisor of Ivana Pejovic
2011 - 2011 Production and purification of human recombinant GRP non-gammacarboxylated
Supervisor of Vera Maria
 Molecular Biology and Microbiology (Master)
Universidade do Algarve, Portugal
2011 - 2011 Extraction, purification and characterization of Native GRP from the adriatic sturgeon (Acipenser nacarii). Studies on the protein stability
Supervisor of Rúben Costa
2011 - 2011 Extraction, purification and characterization of recombinant GRP.
Supervisor of Andreia Silva
Universidade do Algarve, Portugal
2010 - 2010 Purification and characterization of Gla Proteins in the teleost and mammalian model.
Supervisor of Sofia Isabel Franco Cavaco
 Molecular biology and microbiology (Master)
Universidade do Algarve, Portugal
2010 - 2010 Study of the relation between Gla containing proteins and Tumors.
Supervisor of Monica Guerra
 Ciências Biomédicas (Degree)
Universidade do Algarve, Portugal
2010 - 2010 Detection of Gla proteins in Xenopus laevis bone
Supervisor of Tiago Miguel Trancos de Mira Grosso
 Bioquímica (Degree)
Universidade do Algarve, Portugal
2010 - 2010 Detection of Gla-Proteins with the ability to bind Hidroxyapatite mineral in the heart of Gallus gallus domesticus (chicken).
Supervisor of Viegas, Miguel de Sousa
Bioquímica (Degree)
Universidade do Algarve, Portugal
2010 - 2010 A proteomic approach in the isolation and characterization of proteins dependent of Vitamin K present in the skeleton of Blue Shark (Prionace glauca)”(
Supervisor of Mónica Guerra
Universidade do Algarve, Portugal
2005 - 2010 Identification and characterization of a new calcium binding protein from sturgeon, Gla rich protein or GRP: Contribution to unveil its function in vertebrates
Co-supervisor of Carla Alexandra São Bento Viegas
 Bioquímica (PhD)
Universidade do Algarve, Portugal
2009 - 2009 Study of gla containing, vitamin K-dependent proteins associated with skin mineralization pathologies.
Supervisor of Elysse Filipe
 Ciências Biomédicas (Degree)
Universidade do Algarve - Campus de Gambelas, Portugal
2008 - 2008 Proteome characterization of nacre obtained from the oyster Crassostrea Gigas
Supervisor of Daniel Oliveira
 Bioquímica (Degree)
Universidade do Algarve, Portugal
2004 - 2004 Effect of nacre extracts from the oyster Crassostrea Gigas in the mineralization of Sparus aurata bone cells.
Supervisor of Sofia Isabel Franco Cavaco
 Bioquímica (Degree)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2003 - 2003 Purification and cloning of Prionace Glauca Matrix Gla protein
Supervisor of Brian João Schaff
 Biotecnologia (Degree)
Universidade do Algarve, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2025/06/26 - 2025/06/27 3RD Meeting of the Portuguese Network on Extracellular vesicles, Universidade do Algarve Campus de Gambelas (2025/06/26 - 2025/06/27)
Conference (President of the Organising Committee)
2023/07/14 - 2023/07/14 Nutrisafe Workshop - Valorisation of invasive seaweed biomass to develop new products for the blue bioeconomy (2023/07/14 - 2023/07/14)
Workshop (President of the Organising Committee)
 Universidade do Algarve, Portugal
2022/05/11 - 2022/05/13 Congress organization: ProteoVilamoura, 2nd Joint Meeting of Spanish, French and Portuguese Proteomics Societies, 11th to 13th May 2022, Vilamoura, Portugal (https://proteo-vilamoura.sci-meet.net/). (2022/05/11 - 2022/05/13)
Congress (President of the Organising Committee)
2017/06/11 - 2017/06/13 2º Congresso Internacional do CiiEM - Translational Research and Innovation in Human and Health Sciences. (2017/06/11 - 2017/06/13)
Congress (Member of the Scientific Committee)
 Centro de Investigação Interdisciplinar Egas Moniz, Portugal
2016/04/04 - 2016/04/05 Exploitation and Legal Aspects on Marine Genetic and Chemical Resources (2016/04/04 - 2016/04/05)
Workshop (Member of the Scientific Committee)
 Consiglio Nazionale delle Ricerche Area di Ricerca di Napoli 1, Italy
2015/12/15 - 2015/12/15 New, High Throughput Tools and Methods for Label-Free Characterization of Biotherapeutic Molecules. (2015/12/15 - 2015/12/15)
Seminar (Co-organisor)
 Centro de Ciências do Mar, Portugal
2015/12/02 - 2015/12/02 Nanoparticles characterization by NTA-Nanoparticle tracking analysis; concepts and applications by Paralab (2015/12/02 - 2015/12/02)
Seminar (Co-organisor)
 Centro de Ciências do Mar, Portugal
2015/09/21 - 2015/09/25 Biomedical and biological applications of scanning and transmission electron microscopy” (2015/09/21 - 2015/09/25)
Workshop (Member of the Scientific Committee)
 Centro de Ciências do Mar, Portugal
2015/07/01 - 2015/07/03 Three-day proteomics course on 2D-electrophoresis techniques “From 2DE to protein identification by mass spectrometry” (2015/07/01 - 2015/07/03)
Workshop (Member of the Scientific Committee)
 Centro de Ciências do Mar, Portugal
2014/07/02 - 2014/07/04 Three-day proteomics course on 2D-electrophoresis techniques “From 2DE to protein identification by mass spectrometry” (2014/07/02 - 2014/07/04)
Workshop (Member of the Scientific Committee)
 Centro de Ciências do Mar, Portugal
2012/07/11 - 2012/07/12 Workshop on “Strategies for recombinant protein production” (2012/07/04 - 2012/07/06)
Workshop
 Centro de Ciências do Mar, Portugal
2012/07/04 - 2012/07/06 Three-day proteomics course on 2D-electrophoresis techniques “From 2DE to protein identification by mass spectrometry” (2012/07/04 - 2012/07/06)
Workshop (Member of the Scientific Committee)
 Centro de Ciências do Mar, Portugal
2011/07/13 - 2011/07/15 Three-day course on “Strategies for recombinant protein production”, 13-15 July 2011, CCMAR/UALG, Portugal. (2011/07/13 - 2011/07/15)
Workshop (Member of the Scientific Committee)
 Centro de Ciências do Mar, Portugal
2004/12/02 - 2004/12/04 Organization commission of XIV Biochemistry National Congress, Vilamoura 2-4 December 2004, Portugal. (2004/12/02 - 2004/12/04)
Congress (Member of the Organising Committee)
 Sociedade Portuguesa de Bioquímica, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2020/01/23 - 2020/01/23 Do tubo de ensaio ao consultório médico: a importância de biomarcadores no diagnóstico e tratamento de doenças, Escola Dr. Francisco Fernandes Lopes, Olhão – 12º ano
Seminar
 Projeto Cientificamente provável, Ministério da Ciência e Ensino Superior
Universidade do Algarve, Portugal

Centro de Ciências do Mar, Portugal
2019/02/21 - 2019/02/21 Vamos encontrar novos fármacos e cosméticos de origem marinha para tratar doenças e travar o envelhecimento!
Seminar
 Dia Aberto UAlg 2019
Universidade do Algarve, Portugal
2017/03/01 - 2017/03/01 Como podem as proteínas dizer-nos se estamos doentes?, 5ª edição projeto Mitose: Ciência a Sul 2017, Participação de 2 estudantes 11º ano Escola secundária de Manteigas: Duarte Carvalhinho (1º prémio) Matilde Costa (Menção honrosa), CCMAR/Universidade do algarve, Faro, Portugal 01/03/2017
Workshop
 5ª edição projeto Mitose: Ciência a Sul 2017
Universidade do Algarve, Portugal
2016/07/12 - 2016/07/12 Vamos tornar as células humanas fluorescentes!
Seminar
 Cursos de Verão 2016, CCMAR/ Universidade do Algarve
Universidade do Algarve, Portugal
2015/07/06 - 2015/07/17 Como pode o investigador ajudar o médico no diagnóstico da doença osteoartrite?
Workshop
 Ocupação Científica de Jovens no Verão, Estágios CCVIVA Verão
Universidade do Algarve, Portugal
2015/07/07 - 2015/07/07 Como se faz o diagnóstico de doenças no laboratório
Seminar
 Cursos de Verão 2015 CCMAR/UAlg
Universidade do Algarve, Portugal
2015/06/30 - 2015/06/30 Vamos tornar as células humanas fluorescentes!
Seminar
 Dia Aberto UAlg 2015
Universidade do Algarve, Portugal
2015/04/30 - 2015/04/30 Dia Aberto Escola Secundária de Vila Real de Santo António, Como pode a histologia ajudar os médicos no diagnóstico?
Seminar
 Dia Aberto Escola Secundária de Vila Real de Santo António, Como pode a histologia ajudar os médicos no diagnóstico?
Universidade do Algarve, Portugal
2015/02/26 - 2015/02/26 Vamos tornar as células humanas fluorescentes!
Seminar
 Dia Aberto UAlg
Universidade do Algarve, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2018 Farmacogenómica da Depressão.
(Thesis) Main arguer
 Sarah Marques da Silva Patel (Master)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2017 Farmacogenómica do cancro colo-retal.
(Thesis) Main arguer
 Barbara Filipa Ascenso Marrucho (Master)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2017 Aplicação de péptidos marinhos na terapia oncológica.
(Thesis) Main arguer
 Cláudia Isabel Tomé Reis (Master)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2017 Diabetes mellitus Tipo 2 como Doença Inflamatória: anatomia, fisiopatologia e terapêutica,
(Thesis) Main arguer
 Maria Romanciuc (Master)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2017 Clinical application of extracellular vesicles in vascular calcification.
Supervisor
 Catarina Isabel Lousada Marreiros (Master)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2017 Influência da farmacogenómica na terapêutica da artrite reumatoide.
(Thesis) Main arguer
 Inês carolina Ribeiro de Oliveira (Master)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2017 Marine Algae extracts as a source of natural antileishmanial compounds.
(Thesis) Main arguer
 Carolina Amaral Frade Bruno de Sousa (PhD)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2016 The role of vitamin K in osteoarthritis.
Supervisor
 Carla Margarida da Silva Pereira (Master)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2016 Farmacogenómica do cancro da mama.
(Thesis) Main arguer
 Beatriz Rosário Santos Sousa (Master)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2016 Aplicação de fitoterapia como terapêutica coadjuvante e preventiva das doenças inflamatórias intestinais: Colite Ulcerosa e Doença de Crohn.
(Thesis) Main arguer
 Ana Catarina Prates Felismino (Master)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2014 Salt marsh plants as source of bioactive compounds.
(Thesis) Main arguer
 Maria Isabel Rocha (Master)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2013 Study of the association between Gla Rich Protein (GRP) and human blood cells.
Supervisor
 Ruben Costa (Master)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2011 Produção e purificação da proteína GRP humana recombinante não gamacarboxilada.
Supervisor
 Vera Maria (Master)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2010 Purificação e caracterização de proteínas Gla nos modelos peixe e mamífero.
Supervisor
 Sofia Cavaco (Master)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2010 Identification and characterization of a new calcium binding protein from sturgeon, Gla rich protein or GRP: Contribution to unveil its function in vertebrates.
Supervisor
 Carla São-Bento Viegas (PhD)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2008 Study of Perkinsus olseni infection mechanisms: identification and regulation of parasite genes differentially expressed in response to host and environmental stress.
(Thesis) Main arguer
 Rita Margarida Ascenso (PhD)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2005/07 Sequential pathology and localization of IPNV by immunohistochemistry in Atlantic Salmon (Salmo salar L.) post-smolts challenge by cohabitation”
(Thesis) Main arguer
 Andreia Margarida Batista Custódio Cavaco (Other)
Universidade do Algarve, Portugal
2005 Functional analysis of Bone related Gla Proteins from bony fish during skeletal development.
(Thesis) Main arguer
 Gavaia, Paulo Jorge (PhD)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2004/12 “Efeito de extractos de nacre da ostra Crassostrea gigas na mineralização de células de osso de Sparus aurata."
(Thesis) Main arguer
 Sofia Cavaco (Other)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2004/07 “Estudo do metabolismo do cálcio e do efeito da PTHRP no transporte de cálcio, no intestino da dourada Sparus aurata”
(Thesis) Main arguer
 Joana Isabel da Silva Figueiredo (Other)
Universidade do Algarve, Portugal
2003/12 “Purificação e clonagem da proteína Gla da Matriz (MGP) em Prionace glauca (tubarão azul)."
(Thesis) Main arguer
 Brian João Schaff (Other)
Universidade do Algarve, Portugal
2000/12 “Caracterização de uma cultura primária de células derivadas de osso de Dourada (Sparus aurata)”
(Thesis) Main arguer
 António José Ribeiro Pombinho (Other)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
1998/07 “Estudo da acumulação de cádmio na Ostra Portuguesa Crassostrea angulata (Lamarck, 1809)"
(Thesis) Main arguer
 Miguel Jorge Nascimento Madureira (Other)
Universidade do Algarve, Portugal

Association member

Society Organization name Role
2024/07/09 - Current Associação PNEV- Portuguese Network on Extracellular vesicles Board member_ Treasurer
2022/05/24 - Current European Society of Marine BIotechnology Society member
2020 - Current COST ACTION European transdisciplinary networking platform for marine biotechnology (Ocean4Biotech) CA18238 Working Group Participant
2019/11/27 - Current Rede ProCura - Portuguese Proteomics Association: Lisbon, PT Treasurer (Society Board Member)
2019/11/25 - Current Rede Procura- Assocoiação Portuguesa de Proteómica Board member_ Treasurer
2019/07/09 - Current Portuguese Network on Extracellular Vesicles Member
2019/07/09 - Current Portuguese Network on Extracellular Vesicles: Porto, PT Member

Committee member

Activity description
Role 		Institution / Organization
2019/11/27 - Current The Portuguese Association of Proteomics- REDE PROCURA .Board Member

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2016/11/21 - 2016/11/21 Semana da Ciência, Agrupamento de Escolas Pinheiro e Rosa, Faro. Explorar o mar para encontrar novos fármacos e suplementos alimentares que melhoram a nossa saúde. (Ensino básico 3º ciclo) Universidade do Algarve, Portugal
2014/11/24 - 2014/11/24 Do tubo de ensaio ao consultório médico: a importância de biomarcadores no diagnóstico e tratamento de doenças - Escola D. Martinho Castelo Branco – Portimão – 8º e 9º ano - Projeto rede de partilha científica, financiado pela CCVIVA – Agência Nacional para a Cultura Científica e tecnológica, Portugal. (Ensino básico 3º ciclo) Centro de Ciências do Mar, Portugal
2014/01/20 - 2014/01/20 Do tubo de ensaio ao consultório médico: a importância de biomarcadores no diagnóstico e tratamento de doenças - Escola Dr. Francisco Fernandes Lopes – Olhão – 12º ano. Projeto rede de partilha científica, CCVIVA – Agência Nacional para a Cultura Científica e Tecnológica, Portugal. (Ensino secundário) Centro de Ciências do Mar, Portugal
2013/03/20 - 2013/03/20 Do tubo de ensaio ao consultório médico: a importância de biomarcadores no diagnóstico e tratamento de doenças, Escola Secundária José Belchior Viegas – São Brás de Alportel - 12º ano. Projeto rede de partilha científica, financiado pela CCVIVA – Agência Nacional para a Cultura Científica e Tecnológica, Portugal. (Ensino secundário) Centro de Ciências do Mar, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2021/03/10 - Current Review Editor on the Editorial Board of Marine Biotechnology (specialty section of Frontiers in Marine Science and Frontiers in Bioengineering and Biotechnology).
Evaluator

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2021/09/06 RTP3 Algas invadem praias algarvias
2021/09/04 Algas asiáticas invadem Algarve, RTP Online
2021/09/03 Algas em praias do Algarve RTP1 - Portugal em Direto
2021/09/01 Plataforma Digital Algas na Praia apresenta dados obtidos com a colaboração dos cidadãos Voz do Algarve Online
2021/08/10 Plataforma vai monitorizar acumulação de algas nas praias DiáriOnline - Região Sul Online
2021/08/03 Algas nas praias do Algarve incomodam banhistas, TVI jornal das 8, Repetições: TVI24 - Jornal das 8 , 2021-08-03 21:25 TVI24 - Notícias

Interview (tv / radio show)

Program Topic
2022/06/11 - 2022/06/11 CNN Portugal Primeiro Jornal Investigadores do Algarve querem dar uma nova vida às algas através de suplementos alimentares

Mentoring / Tutoring

Topic Student name
2010/10/01 - 2017/09/01 Studies for the establishment of GRP as a biomarker for ectopic calcifications. Insights into the role of GRP in tumoral processes. (SFRH/BPD/70277/2010 Postdoctoral fellowship) Carla Alexandra São Bento Viegas
2013/01/01 - 2016/01/01 Gla rich protein (GRP) role in human vascular calcification. (SFRH/BPD/89188/2012 PostDoctoral Fellowship) Marta Sofia Rafael
2015 - 2015 CCMAR/BI/0020/2014 (2015) Lúcia Santos
2015 - 2015 CCMAR/BI/0018/2015 (2015) Nuna Araújo
2015 - 2015 CCMAR/BI/0005/2015 (2015) Nuna Araújo
2013 - 2014 CCMAR/BI/0005/2013 (2013-2014) Sofia Santos
2012 - 2013 CCMAR/BI/0031/2012 (2013) Inês Luis
2012 - 2012 CCMAR/BI/0020/2014 (2013-2014) Inês Luis
2011 - 2012 CCMAR/BPD/0035/2011 (2011-2012) Marta Rafael
2010 - 2011 CCMAR/BI/0019/2010 (2010-2011) Carla Alexandra São Bento Viegas
2010 - 2011 CCMAR/BPD/0030/2010 (2011) Carla Viegas
2010 - 2010 CCMAR/BI/0019/2014 (2014-2015) Rúben Costa
2009 - 2009 CCMAR/BI/0020/2011 (2011) Pedro Palma
2009 - 2009 CCMAR/BI/0039/2013 (2013-2014) Rúben Costa

Other jury / evaluation

Activity description Institution / Organization
2020/04/27 - Current Topic Board Member of the international peer-reviewed open access journal Molecules (MDPI)
2018/11/27 - Current International External evaluator and reviewer for an International Doctor Title “Standardization of platelet rich plasma as a drug for osteoarthritis" Lucía Gato Calvo, PhD student, Rheumatology Researh Group, at the Biomedical Research Institute of A Coruña (INIBIC).
2021/02/01 - 2021/12/31 Guest Editor for Special Issue on " Vitamin K and Vitamin K-Dependent Proteins in Homeostasis and Pathology " in the International Journal of Molecular Sciences (Impact Factor 4.556).
2020/09/22 - 2020/10/13 Avaliador projetos de investigação do Sistema de Incentivos (ANI).
2015 - 2020 Reviewer for International Journals:The Journal of Physiology Endokrynologia Polska Thrombosis and Haemostasis ATVB PlosONE Molecules Antioxidants Circulation Journal FEBSOpen Bio International Journal of Biological Macromolecules Histology and Histopathology Theranostics IJMS Journal of Cellular and Molecular Medicine Journal of Extracellular Vesicles Food & Function International Journal of Nephrology and Renovascular Disease British Journal of Pharmacology Nutrients Acta Biomaterialia
2018/07/15 - 2018/08/05 Summer School SHOU, 2018. "Bioactivity of marine compounds". FBP-CCMAR (Laboratório anfitrião) Supervised 3 PhD students from SHOU University. Duração: 15/07/2018 a 05/08/2018. Centro de Ciências do Mar, Portugal
2018 - 2018 Expert and evaluator of one project proposal for the French ATIP-Avenir program 2018 organized by CNRS and INSERM.
2017/07/09 - 2017/08/01 Summer School SHOU, 2017. "Testing marine bioproducts as potential novel cosmetics". FBP-CCMAR. Supervised 3 PhD students from SHOU University Duração: 09/07/2017 a 01/08/2017. Orientação: Viegas, CSB, Araújo, N, Simes, DC Centro de Ciências do Mar, Portugal
2016 - 2016 Reviewer and evaluator of research project proposal submitted to the Dutch Arthritis Foundation (Reumafonds)
Distinctions

Award

2024 Award BInov
2023 Award for the best abstract submitted in the area of peritoneal dialysis
2020 Award Roche - Teresa Azevedo/SPN
2019 Best oral communication XVI MANAPRO & XI ECMNP
2019 Research Project Award
Sociedade Portuguesa de Nefrologia, Portugal
2019 Award Fresenius Medical Care- Jacinto Simões
Sociedade Portuguesa de Nefrologia, Portugal
2018 Best oral communication in "Nefrologia de ligação/Encontro renal 2018"
Sociedade Portuguesa de Nefrologia, Portugal
2017 Award Roche-Teresa Azevedo
Sociedade Portuguesa de Nefrologia, Portugal
2017 Research Project Award
Sociedade Portuguesa de Nefrologia, Portugal
2014 Best poster Prize XVII Congresso Nacional Bioquímica
2010 Award Fresenius Medical Care- Jacinto Simões
Sociedade Portuguesa de Nefrologia, Portugal
2009 Ideas and Business Promotion Award FINICIA - IAPMEI