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I always had a thirst for knowledge about how our brains work. Therefore, I decided to graduate in Health Sciences at Universidade de Lisboa with the purpose of accomplishing an overview about the important topics to connect all the concepts in this subject. Later, I enrolled in a Master’s Degree, in Neurosciences at Faculdade de Medicina da Universidade de Lisboa. This fact enriched my curricular experience and personal achievements and gave me the opportunity to work on my master thesis at Instituto de Farmacologia e Neurociências (Instituto de Medicina Molecular). Thus, I have had excellent opportunities to be exposed to research and laboratory-based environments and, consequently, I have become even more fascinated about the world of neurosciences. Furthermore, I had the chance to expand a network with experts in the field and the opportunity to collaborate effectively in their work in order to publish our results in international journals. All these experiences have built my confidence to work more independently as a researcher. My master thesis was centred on synaptic dysfunction and neurotrophic factors in Alzheimer’s disease and now my interests for my PhD thesis are still focused on the same topic but in the context of schizophrenia, a psyquiatric disorder. The fact that different disorders could have common features had always captivated my attention. Therefore, it is my aspiration to clarify and decipher this mechanisms in psychiatric disorders where it is urgent to disclose novel therapeutic approaches in order to fill the gaps in their treatment. I use molecular and functional ex vivo and in vivo approaches, in a tight collaboration with a group at the University in Lancaster who have high expertise in animal models of schizophrenia. The collaboration is further reinforced by the fact that Lisbon and Lancaster groups belong to a twinning action financed by the H2020 EU framework. Taking in account my experience in the techniques I am proposed to perform as well as my enthusiasm and interest in this project, it is my determination to be an active and helpful member in this team.
Identification

Personal identification

Full name
Sara Luisa Ramalho Tanqueiro

Citation names

  • Tanqueiro SR

Author identifiers

Ciência ID
6818-4322-9ED9
ORCID iD
0000-0002-9151-7149

Email addresses

  • saratanqueiro@medicina.ulisboa.pt (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2016/11/01 - 2020/11/01
Ongoing
The Lisbon University Doctoral Program in Integrative Neuroscience (Doutoramento)
Faculdade de Medicina da Universidade de Lisboa, Portugal
2019/09/20 - 2020/06/19
Concluded
Gestão e Politicas de Ciência e Tecnologia (Pós-Graduação)
Faculdade de Ciências Sociais e Humanas da Universidade NOVA de Lisboa, Portugal
2016
Concluded
Neurociências (Mestrado)
Universidade de Lisboa Faculdade de Medicina, Portugal
"Deciphering the mechanisms underlying the loss of BDNF neuroprotection in an Alzheimer's Disease model" (THESIS/DISSERTATION)
18
2013
Concluded
Ciências da Saúde (Licenciatura)
Universidade de Lisboa, Portugal
"-" (THESIS/DISSERTATION)
14
Affiliation

Science

2021/01/01 - Current Science and Technology Management
Instituto de Engenharia de Sistemas e Computadores Investigação e Desenvolvimento em Lisboa, Portugal

Others

2016/11/01 - Current PhD student
Instituto de Medicina Molecular, Portugal
2016/02/19 - 2016/10/31 Volunteer researcher
Instituto de Medicina Molecular, Portugal
2014/07/01 - 2016/02/18 Master student in Neurosciences
Instituto de Medicina Molecular, Portugal
Projects

Grant

Designation Funders
2018 - 2021 TrkB-FL receptor cleavage as a new marker in Alzheimer’s Disease
0000000
Researcher
Instituto de Medicina Molecular, Portugal
2016 - 2020/10/31 Adenosinergic signaling as a new pharmacological target for schizophrenia treatment?
PD/BD/128091/2016
PhD Student Fellow
Instituto de Medicina Molecular, Portugal
2017 - 2020 Regulation of adenosine levels as a new therapeutic strategy for Rett Syndrome
00000000000000
Researcher
Instituto de Medicina Molecular, Portugal
Association Française du Syndrome de Rett
2017 - 2020 Novel therapeutic strategy and new biomarker for Alzheimer´s Disease based on BDNF receptor cleavage
MB-37-2017
Researcher
Instituto de Medicina Molecular, Portugal
Santa Casa da Misericórdia de Lisboa

Other

Designation Funders
2017 - 2018 Adenosinergic signaling as a new pharmacological target for schizophrenia treatment?
20180014
Supervisor
Instituto de Medicina Molecular, Portugal
Faculdade de Medicina da Universidade de Lisboa
Outputs

Publications

Conference abstract
  1. Sara R Tanqueiro; Francisco M. Mouro; Ana M. Sebastião; Frederico S. Do Couto; Neil Dawson; Maria José Diógenes. "Does BDNF loss of function in the prefrontal cortex underlie cognitive deficits in the subchronic phencyclidine model of schizophrenia?". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), 2019.
    Published
Conference poster
  1. Tanqueiro SR. "Does BDNF loss of function in the prefrontal cortex underlie cognitive deficits in the subchronic phencyclidine model of schizophrenia?". Paper presented in XVI Meeting Sociedade Portuguesa de Neurociências, Tryp Hotel Lisboa Aeroporto, Lisbon, Portugal, 2019.
  2. Tanqueiro SR. "Interplay between BDNF signalling and cognitive alterations in the subchronic phencyclidine model of schizophrenia". Paper presented in XIII CAML PhD Students' Meeting. Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal., 2019.
  3. Tanqueiro, Sara. "Does BDNF loss of function in the prefrontal cortex underlie cognitive deficits in the subchronic phencyclidine model of schizophrenia?". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience, 2019.
  4. Tanqueiro, Sara. "BDNF loss of function in the prefrontal cortex may underlie cognitive deficits in the subchronic phencyclidine model of schizophrenia". Paper presented in Gordon Research Conference on Neurotrophic Mechanisms in Health and Disease, 2019.
  5. Tanqueiro, Sara. "BDNF signaling and adenosinergic system alterations in a mice model of schizophrenia.". Paper presented in 2nd Annual Scientific Synanet Meeting, 2018.
  6. Tanqueiro, Sara. "Scrutinizing the relationship between BDNF signalling impairments and cognitive dysfunction in an animal model of schizophrenia". Paper presented in XII CAML PhD Students' Meeting, 2018.
  7. Tanqueiro, Sara. "Interplay between the loss of BDNF signalling and cognitive dysfunction in schizophrenia?: insights from the subchronic phencyclidine model". Paper presented in FENS Forum 2018, 2018.
  8. Tanqueiro, Sara. "Interplay between the loss of BDNF signalling and cognitive dysfunction in the subchronic phencyclidine model of schizophrenia". Paper presented in Society for Neuroscience 2018, San Diego, USA, 2018.
  9. Tanqueiro, Sara. "The loss of BDNF signaling and cognitive dysfunction in the subchronic Phencyclidine model of schizophrenia". Paper presented in 4th Meeting of the PhD students from the Mind-Brain Doctoral College of the University of Lisbon, 2018.
  10. Tanqueiro, Sara. "Impact of a high sugar diet during rat aging on synaptic plasticity, hippocampal neurogenesis and behaviour performance". Paper presented in 4th Meeting of the PhD students from the Mind-Brain Doctoral College of the University of Lisbon, 2018.
  11. Tanqueiro, Sara. "Amyloid ß induces BDNF loss of function by a mechanism dependent on Extrasynaptic NMDA receptors activation". Paper presented in 1st Annual Scientific Synanet Meeting, 2017.
  12. Tanqueiro, Sara. "Amyloid ß induces BDNF loss of function by a mechanism dependent on Extrasynaptic NMDA receptors activation". Paper presented in XV Portuguese Society for Neuroscience meeting, 2017.
  13. Tanqueiro, Sara. "Deregulation of BDNF signaling in a mice model of schizophrenia". Paper presented in 3rd Meeting of the PhD students from the Mind-Brain Doctoral College of the University of Lisbon, 2017.
  14. Tanqueiro, Sara. "Amyloid ß induces BDNF loss of function by a mechanism dependent on Extrasynaptic NMDA receptors activation". Paper presented in 2nd Meeting of the PhD students from the Mind-Brain Doctoral College of the University of Lisbon, 2016.
  15. Tanqueiro, Sara. "Restoring the protective function of BDNF in Alzheimer's disease". Paper presented in 3rd IMM Postdoc Day Meeting, 2015.
  16. Tanqueiro, Sara. "Deciphering the mechanisms underlying the loss of BDNF neuroprotection in an Alzheimer’s Disease model". Paper presented in 1st Meeting of the PhD students from the Mind-Brain Doctoral College of the University of Lisbon, 2015.
Journal article
  1. Miranda-Lourenço, Catarina; Ribeiro-Rodrigues, Leonor; Fonseca-Gomes, João; Tanqueiro, Sara R.; Belo, Rita F.; Ferreira, Catarina B.; Rei, Nádia; et al. "Challenges of BDNF-based therapies: From common to rare diseases". Pharmacological Research 162 (2020): 105281. http://dx.doi.org/10.1016/j.phrs.2020.105281.
    10.1016/j.phrs.2020.105281
  2. Fonseca-Gomes, João; Loureiro, Joana A; Tanqueiro, Sara R; Mouro, Francisco M; Ruivo, Pedro; Carvalho, Tânia; Sebastião, Ana M; Diógenes, Maria José; Pereira, Maria Carmo. "

    In vivo Bio-Distribution and Toxicity Evaluation of Polymeric and Lipid-Based Nanoparticles: A Potential Approach for Chronic Diseases Treatment

    ". International Journal of Nanomedicine Volume 15 (2020): 8609-8621. http://dx.doi.org/10.2147/ijn.s267007.
    10.2147/ijn.s267007
  3. Rodrigues, Rui S.; Paulo, Sara L.; Moreira, João B.; Tanqueiro, Sara R.; Sebastião, Ana M.; Diógenes, Maria J.; Xapelli, Sara. "Adult Neural Stem Cells as Promising Targets in Psychiatric Disorders". Stem Cells and Development 29 17 (2020): 1099-1117. http://dx.doi.org/10.1089/scd.2020.0100.
    10.1089/scd.2020.0100
  4. Sa de Almeida, Joana; Vargas, Mariana; Fonseca-Gomes, João; Tanqueiro, Sara Ramalho; Belo, Rita F.; Miranda-Lourenço, Catarina; Sebastião, Ana M.; Diógenes, Maria José; Pais, Teresa F.. "Microglial Sirtuin 2 Shapes Long-Term Potentiation in Hippocampal Slices". Frontiers in Neuroscience 14 (2020): http://dx.doi.org/10.3389/fnins.2020.00614.
    10.3389/fnins.2020.00614
  5. Tanqueiro, Sara R.; Ramalho, Rita M.; Rodrigues, Tiago M.; Lopes, Luísa V.; Sebastião, Ana M.; Diógenes, Maria J.. "Inhibition of NMDA Receptors Prevents the Loss of BDNF Function Induced by Amyloid ß". Frontiers in Pharmacology 9 (2018): http://dx.doi.org/10.3389/fphar.2018.00237.
    Published • 10.3389/fphar.2018.00237
  6. Ribeiro, Filipa F.; Xapelli, Sara; Miranda-Lourenço, Catarina; Tanqueiro, Sara R.; Fonseca-Gomes, João; Diógenes, Maria J.; Ribeiro, Joaquim A.; Sebastião, Ana M.. "Purine nucleosides in neuroregeneration and neuroprotection". Neuropharmacology 104 (2016): 226-242. http://dx.doi.org/10.1016/j.neuropharm.2015.11.006.
    10.1016/j.neuropharm.2015.11.006
  7. Jerónimo-Santos, André; Fonseca-Gomes, João; Guimarães, Diogo Andrade; Tanqueiro, Sara Ramalho; Ramalho, Rita Mira; Ribeiro, Joaquim Alexandre; Sebastião, Ana Maria; Diógenes, Maria José. "Brain-derived neurotrophic factor mediates neuroprotection against Aß-induced toxicity through a mechanism independent on adenosine 2A receptor activation". Growth Factors 33 4 (2015): 298-308. http://dx.doi.org/10.3109/08977194.2015.1080696.
    10.3109/08977194.2015.1080696
Thesis / Dissertation
  1. Tanqueiro, Sara Luísa Ramalho, 1992-. "Deciphering the mechanisms underlying the loss of BDNF neuroprotection in an Alzheimer’s disease model". Master, 2016. http://hdl.handle.net/10451/23773.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/11/12 "Is there any relation between BDNF loss of function and cognitive deficits in phencyclidine-induced mouse model of schizophrenia?" 5th Meeting of PhD students from the Mind-Brain Doctoral College of the University of Lisbon
(li, Portugal)
2019/03/21 "Interplay between BDNF signalling and cognitive alterations in the subchronic phencyclidine model of schizophrenia" Meeting of NeurULisboa Doctoral Programme, Instituto de Medicina Molecular, Lisboa.
(li, Portugal)
2019/03/19 "Interplay between BDNF signaling and cognitive alterations in the subchronic phencyclidine mouse model of schizophrenia" iMM Pizza Seminar. Instituto de Medicina Molecular João Lobo Antunes, Lisbon, Portugal
(li, Portugal)
2019/03/15 "O Cérebro" in the context of the Brain Awareness Week promoted by DANA Foundation
Escola Secundária António Damásio, Lisbon (Lisb, Portugal)
2018/12 "Dysfunction of BDNF signaling in the prefrontal cortex as a potential key to understand cognitive alterations in the subchronic phencyclidine model of schizophrenia”. 3rd Annual Meeting of the Neurologic and Psychiatric Disorders: from synapses to networks (SynaNet) H2020 Twinning Project
(lisboa, Portugal)
2018/11 “The loss of BDNF signaling and cognitive dysfunction in the subchronic Phencyclidine model of schizophrenia” 4th Meeting of PhD students from the Mind-Brain Doctoral College of the University of Lisbon
(lis, Portugal)
2018/02/05 “NMDA receptors play a key role in Amyloid Beta-mediated BDNF loss of function” XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia
(Lisboa)
2017/04/26 "O Cérebro" in the context of the Brain Awareness Week promoted by DANA Foundation
Escola Secundária Eça de Queirós, Lisbon
2016/04/14 “Curiosidades sobre o cérebro, desenvolvimento e patologias” during Brain Awareness Week promoted by Dana Alliance for Brain Initiatives.
Colégio Pedro Arrufe, Lisboa
2016/02/04 “Extrasynaptic NMDA receptors inhibition prevents the loss of BDNF functions in the context of Alzheimer’s Disease” XLVI Reunião Anual da Sociedade Portuguesa de Farmacologia
(Porto, Portugal)

Event organisation

Event name
Type of event (Role)
Institution / Organization
2018/09/28 - Current Noite Europeia dos Investigadores 2018, Museu Nacional de História Natural e da Ciência e Jardim do Príncipe Real (2018/09/28)
Exhibition (Co-organisor)
2017/03/12 - Current Opening Session of Brain Awareness Week entitled “Cérebro e actividade física“ (2017/03/12)
Other (Member of the Organising Committee)
2019/11/12 - 2019/11/13 5th Meeting of the PhD students from the Mind-Brain Doctoral College of the University of Lisbon (2019/11/14 - 2019/11/15)
Meeting
Universidade de Lisboa, Portugal
2019/06/29 - 2019/06/30 XVI Meeting of the Portuguese Society for Neuroscience (2019/06/29 - 2019/06/30)
Conference (Member of the Organising Committee)
2018/11/14 - 2018/11/15 4th Meeting of the PhD students from the Mind-Brain Doctoral College of the University of Lisbon (2018/11/14 - 2018/11/15)
Meeting (Member of the Organising Committee)
Universidade de Lisboa, Portugal
2018/02/05 - 2018/02/07 XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia, Lisbon (2018/02/05 - 2018/02/07)
Meeting (Member of the Organising Committee)
Universidade de Lisboa, Portugal
2017/10/19 - 2017/10/20 3rd Meeting of the PhD students from the Mind-Brain Doctoral College of the University of Lisbon (2017/10/19 - 2017/10/20)
Meeting (Member of the Organising Committee)
Universidade de Lisboa, Portugal
2016/11/28 - 2016/11/29 2nd Meeting of the PhD students from the Mind-Brain Doctoral College of the University of Lisbon (2016/11/28 - 2016/11/29)
Meeting (Member of the Organising Committee)
Universidade de Lisboa, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2019/10/15 - Current Portuguese Legislation on Animal Use in Research, Champalimaud Centre for The Unknown, Portugal
Other
Portuguese Legislation on Animal Use in Research
Champalimaud Centre for The Unknown, Portugal
2017/06/01 - Current Workshop on Science Communication with Professor Malcolm Love, University of Lisbon, Portugal
Workshop
2018/06/21 - 2018/06/22 Workshop on “Design and communication in Science”, University of Lisbon
Workshop
2018/06/11 - 2018/06/15 Workshop on "Signals from the Brain", from the H2020 Twinning action SynaNet - "Neurologic and Psychiatric Disorders: from synapses to networks" in Sapienza Università di Roma, Italy
Workshop
Workshop on "Signals from the Brain"
Università degli Studi di Roma La Sapienza, Italy
2017/12/12 - 2017/12/14 Workshop on "Flow Citometry", from the H2020 Twinning action SynaNet - "Neurologic and Psychiatric Disorders: from synapses to networks" in University of Eastern Finland, Kuopio
Workshop
Workshop on "Flow Citometry"
University of Eastern Finland, Finland
2017/07/17 - 2017/07/19 Animal training Course for PILA, PILB and PILC, Manchester University, UK
Other
Animal training Course for PILA, PILB, PILC
2016/10/26 - 2016/10/28 Workshop on "Neuroinflammation", from the H2020 Twinning action SynaNet - "Neurologic and Psychiatric Disorders: from synapses to networks" in University of Eastern Finland, Kuopio
Workshop
Workshop on "Neuroinflammation"
University of Eastern Finland, Finland
2016/09/26 - 2016/09/27 Workshop on "Behavioural Models of Disease: of Flies, Mice and Men", from the H2020 Twinning action SynaNet - "Neurologic and Psychiatric Disorders: from synapses to networks" in Lancaster University, UK
Workshop
Workshop "Behavioural Models of Disease: of Flies, Mice and Men"
Lancaster University, United Kingdom
2016/08/08 - 2016/08/12 Summer School on "Machine Learning and Bioinformatics" in University of Eastern Finland
Workshop
Machine Learning and Bioinformatics
University of Eastern Finland, Finland
2015/11/04 - 2015/11/06 Bioimaging Course on Microscopy, CAML Advanced Course¿, Lisbon, Portugal.
Other
2013/11/19 - 2013/11/20 Formação de Animadores Científicos - Science4you
Other

Association member

Society Organization name Role
2016 - Current Sociedade Portuguesa de Neurociências Member

Committee member

Activity description
Role
Institution / Organization
2016/11/01 - Current Member of Students Commission of the Mind-Brain College, University of Lisbon
Member

Mentoring / Tutoring

Topic Student name
2019/09/01 - Current Céline Felicidade Freitas
Distinctions

Award

2018 Travel grant and accommodation awarded by SynaNet Twinning Action to attend to “Signals from the Brain” Summer School , Rome, Italy
2017 Travel grant and accommodation awarded by SynaNet Twinning Action to attend to "Flow Cytometry" Workshop, University of Eastern Finland, Finland
2017 Researcher in a team awarded with the Prémio Mantero Belard funded by Santa Casa da Misericórdia
2017 Researcher in a team awarded by Association Française du Syndrome de Rett
2016 Travel grant and accommodation awarded by SynaNet Twinning Action to attend to "Neuroinflammation" Workshop, University of Eastern Finland, Finland
2016 Travel grant and accommodation awarded by SynaNet Twinning Action to attend to "Behavioural Models of Disease: of Flies, Mice and Men" Workshop, Lancaster University, UK
2016 Travel grant and accommodation awarded by SynaNet Twinning Action to attend to "Machine Learning and Bioinformatics" Summer School, University of Eastern Finland, Finland