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Identification

Personal identification

Full name
Diana Sofia Gesto da Silva

Citation names

  • Gesto, Diana S.

Author identifiers

Ciência ID
6816-CA6C-6433
ORCID iD
0000-0002-3583-8407
Google Scholar ID
https://scholar.google.com/citations?user=EFs1_IAAAAAJ&hl=en
Scopus Author Id
55094014200

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
  • Exact Sciences - Chemical Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
English Advanced (C1) Proficiency (C2) Advanced (C1) Proficiency (C2)
Italian Intermediate (B1) Advanced (C1) Intermediate (B1) Intermediate (B1)
Spanish; Castilian Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
German Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2012/01 - 2017/05
Concluded
 Doutoramento em Química na especialidade de Química Teórica e Modelação Molecular (Doutoramento)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Faculdade de Engenharia, Portugal

Università della Calabria, Italy
"New Therapeutic Strategies to Lower Blood Stream Cholesterol Levels through the Inhibition of HMG-CoA Reductase" (THESIS/DISSERTATION)
 n/a
2011/10/01 - 2012/05/31
Concluded
 Italiano A2 (Outros)
Universidade do Porto Faculdade de Letras, Portugal
 18
2010/10/01 - 2012/05/01
Concluded
 Alemão B1 (Outros)
Universidade do Porto Faculdade de Letras, Portugal
 19
2008 - 2010
Concluded
 Bioquímica (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Estudo do Mecanismo Reaccional da Enzima L- asparaginase através de Métodos Computacionais." (THESIS/DISSERTATION)
 17
2008/09/26 - 2009/06/08
Concluded
 Alemão A2 (Outros)
Universidade do Porto Faculdade de Letras, Portugal
 19
2007/10/04 - 2008/11/04
Concluded
 Alemão A1 (Outros)
Universidade do Porto Faculdade de Letras, Portugal
 16
2005/09 - 2008/09
Concluded
 Bioquímica (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Identificação de genes reguladores da proliferação e diferenciação em Drosophila melanogaster (mosca da fruta)." (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2018/12/18 - Current Contracted Researcher (Research) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2017/10/01 - 2018/12/18 Postdoc (Research) REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2013/02 - 2014/02 Visiting Researcher (Research) Fundação para a Ciência e a Tecnologia, Portugal
Università della Calabria Dipartimento di Chimica e Tecnologie Chimiche, Italy
2010/10/15 - 2011/10/15 Researcher (Research) REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
Projects

Grant

Designation Funders
2012/01/01 - 2017/05/31 New Therapeutic Strategies to Lower Blood Stream Cholesterol Levels through the Inhibition of HMG-CoA Reductase
SFRH/BD/78724/2011
PhD Student Fellow
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2018/09/01 - 2018/12/18 New Technologies for three Health Challenges of Modern Societies: Diabetes, Drug Abuse and Kidney Diseases
NORTE-01-0145-FEDER-000024
HEALTH RL1_PHD_GQC_05
Post-doc
Outputs

Publications

Conference poster
  1. Gesto, Diana S.; Özaydin, Beste; Fernandes, Pedro Alexandrino; Ramos, Maria Joao. "From serotonin to melatonin - computational insights on the mechanism of serotonin N-acetyltransferase". Paper presented in International Conference on Catalysis Science, Engineering & Technology, 2018.
  2. Gesto, Diana S.; Nuno, NMFSA; Fernandes, Pedro Alexandrino; Ramos, Maria Joao. "Understanding the reaction mechanism of L-asparaginase II – a computational study". Paper presented in X Girona Seminar on Theoretical and Computational Chemistry for the Modeling of Biochemical Systems: From Theory to Applications, 2012.
  3. Gesto, Diana S.; Cerqueira, NMFSA; Fernandes, Pedro Alexandrino; Ramos, Maria Joao. "Unveiling the Catalytic Mechanism of L-asparaginase II using Computational Methods". Paper presented in 3PYCheM - 3rd Portuguese Young Chemists Meeting, 2012.
  4. Gesto, Diana S.; Cerqueira, NMFSA; Fernandes, Pedro Alexandrino; Ramos, Maria Joao. "Theoretical Insights on the Mechanism of L-asparaginase II". Paper presented in THEOBIO 2011 - 5th Symposium on Theoretical Biophysics, 2011.
  5. Gesto, Diana S.; Cerqueira, NMFSA; Fernandes, Pedro Alexandrino; Ramos, Maria Joao. "Unraveling the Enigmatic Mechanism of Asparaginase: a Key Enzyme in the Battle against Cancer". Paper presented in 2o Encontro Nacional de Química Terapêutica, 2010.
  6. Gesto, Diana S.; Cerqueira, NMFSA; Fernandes, Pedro Alexandrino; Ramos, Maria Joao. "Theoretical and Computational Studies addressed to Asparaginase". Paper presented in IJUP 2010 - 3rd Meeting of Young Researchers of U. Porto, 2010.
Journal article
  1. Gesto, Diana S.. "Towards the mechanistic understanding of enzymatic CO2 reduction". ACS Catalysis (2020): http://dx.doi.org/10.1021/acscatal.0c00086.
    10.1021/acscatal.0c00086
  2. Listyarini, R.V.; Gesto, D.S.; Paiva, P.; Ramos, M.J.; Fernandes, P.A.. "Benchmark of density functionals for the calculation of the redox potential of Fe3+/Fe2+ within protein coordination shells". Frontiers in Chemistry 7 JUN (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85068569709&partnerID=MN8TOARS.
    10.3389/fchem.2019.00391
  3. Cerqueira, N.M.F.S.A.; Oliveira, E.F.; Gesto, D.S.; Santos-Martins, D.; Moreira, C.; Moorthy, H.N.; Ramos, M.J.; Fernandes, P.A.. "Cholesterol Biosynthesis: A Mechanistic Overview". Biochemistry 55 39 (2016): 5483-5506. http://www.scopus.com/inward/record.url?eid=2-s2.0-84990047814&partnerID=MN8TOARS.
    10.1021/acs.biochem.6b00342
  4. Diana Gesto. "Lípidos". Revista de Ciência Elementar 3 2 (2015): https://doi.org/10.24927/rce2015.146.
    10.24927/rce2015.146
  5. Cerqueira, N.M.F.S.A.; Gesto, D.; Oliveira, E.F.; Santos-Martins, D.; Brás, N.F.; Sousa, S.F.; Fernandes, P.A.; Ramos, M.J.. "Receptor-based virtual screening protocol for drug discovery". Archives of Biochemistry and Biophysics (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84933074226&partnerID=MN8TOARS.
    10.1016/j.abb.2015.05.011
  6. Diana Gesto. "Glicerol". Revista de Ciência Elementar 2 4 (2014): https://doi.org/10.24927/rce2014.277.
    10.24927/rce2014.277
  7. Diana Gesto. "Ácidos Gordos". Revista de Ciência Elementar 2 4 (2014): https://doi.org/10.24927/rce2014.278.
    10.24927/rce2014.278
  8. Gesto DS; Cerqueira NM; Ramos MJ; Fernandes PA. "Discovery of new druggable sites in the anti-cholesterol target HMG-CoA reductase by computational alanine scanning mutagenesis.". (2014): http://europepmc.org/abstract/med/24671303.
    10.1007/s00894-014-2178-8
  9. Gesto, D.S.; Cerqueira, N.M.F.S.A.; Fernandes, P.A.; Ramos, M.J.. "Unraveling the enigmatic mechanism of l-asparaginase II with QM/QM calculations". Journal of the American Chemical Society 135 19 (2013): 7146-7158. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877811918&partnerID=MN8TOARS.
    10.1021/ja310165u
  10. Gesto, D.S.; Cerqueira, N.M.F.S.A.; Fernandes, P.A.; Ramos, M.J.. "Gemcitabine: A critical nucleoside for cancer therapy". Current Medicinal Chemistry 19 7 (2012): 1076-1087. http://www.scopus.com/inward/record.url?eid=2-s2.0-84858173640&partnerID=MN8TOARS.
Thesis / Dissertation
  1. Diana Sofia Gesto da Silva. "New Therapeutic Strategies to Lower Blood Stream Cholesterol Levels through the Inhibition of HMG-CoA Reductase". PhD, 2017. https://hdl.handle.net/10216/105483.
  2. Gesto, Diana S.. "Estudo do Mecanismo Reaccional da L-asparaginase através de Métodos Computacionais". Master, Universidade do Porto Faculdade de Ciências, 2010.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2018/05/10 Métodos Computacionais Alternativos no Desenvolvimento de Novos Fármacos 2º Encontro de Investigadores do DQB
Universidade do Porto - Departamento de Química (Porto, Portugal)
2011/02/17 L-asparaginase II: Computational Studies on a New Chemotherapeutic Enzyme IJUP 2011 - 4rd Meeting of Young Researchers of U. Porto
Universidade do Porto (Porto, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2018/03/02 - 2018/07/11 Estudo da transferência de um protão envolvido no mecanismo da serotonina.
Co-supervisor of Rita Isabel Carvalho de Sousa
 Licenciatura em Química (Degree)
Universidade do Porto Departamento de Química e Bioquímica, Portugal
2018/02/03 - 2018/07/11 Estudo do segundo passo da Biossíntese de Serotonina
Co-supervisor
 Licenciatura em Química (Degree)
Universidade do Porto Faculdade de Ciências, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2016/09/05 - 2016/10/01 Organizing committee of the "European Master in Theoretical Chemistry and Computational Modelling - 11th Intensive Course" (2016/09/05 - 2016/10/01)
Other (Member of the Organising Committee)
 Universidade do Porto Faculdade de Ciências, Portugal
2016/02/17 - 2016/02/19 Organizing committee of "IJUP 2016 - 9th Meeting of Young Researchers of U. Porto". (2016/02/17 - 2016/02/19)
Meeting (Member of the Organising Committee)
 Universidade do Porto, Portugal
2015/05/13 - 2015/05/15 Organizing committee of "IJUP 2015 - 8th Meeting of Young Researchers of U. Porto". (2015/05/13 - 2015/05/15)
Meeting (Member of the Organising Committee)
 Universidade do Porto, Portugal
2012/05/04 - 2012/05/08 Organizing committee of the "CODECS: COnvergent Distributed Environment for Computational Spectroscopy - Workshop with Management Committee and Workgroup meeting in Porto". (2012/05/04 - 2012/05/08)
Workshop (Member of the Organising Committee)
 Universidade do Porto Departamento de Química e Bioquímica, Portugal
2011/06/08 - 2011/06/12 Organizing committee of the conference "THEOBIO 2011 - 5th Symposium on Theoretical Biophysics", held at Funchal Madeira from 8 to 12 June 2011. (2011/06/08 - 2011/06/12)
Conference (Member of the Organising Committee)
 Universidade do Porto Departamento de Química e Bioquímica, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2020/02/27 - 2020/02/28 Participation in the course "Design Thinking 21th edition", held at Universidade Nova de Lisboa from 27 to 28 of February 2020.
Workshop
 Design Thinking 21th edition
Universidade Nova de Lisboa Centro de Gestão de Informação e Conhecimento, Portugal
2018/12/21 - 2018/12/21 Participation in the "EJIBCE - Encontro de Jovens Investigadores de Biologia Computacional Estrutural 2018".
Meeting
 EJIBCE - Encontro de Jovens Investigadores de Biologia Computacional Estrutural 2018
Universidade do Porto Faculdade de Medicina, Portugal
2018/11/04 - 2018/11/07 Presentation of the poster "From serotonin to melatonin - computational insights on the mechanism of serotonin N-acetyltransferase" at "International Conference on Catalysis Science, Engineering & Technology - 2018", held at the Conference Centre, M/S Mariella, Stockholm, Sweden from 4 to 7 November 2018.
Conference
 International Conference on Catalysis Science, Engineering & Technology - 2018
2017/07/09 - 2017/07/14 Supervisor in the "School of Chemistry and Biochemistry"
Other
 School of Chemistry and Biochemistry
Universidade do Porto Faculdade de Ciências, Portugal
2015/07/06 - 2015/07/10 Supervisor in the "School of Chemistry and Biochemistry"
Other
 School of Chemistry and Biochemistry
Universidade do Porto Faculdade de Ciências, Portugal
2015/06/15 - 2015/06/19 Participation in the workshop "NMR Focus - NMR and Modelling Methods for Protein Interactions and Drug Design.", help at the University of Coimbra from 15 to 19 of June 2015.
Workshop
 NMR Focus - NMR and Modelling Methods for Protein Interactions and Drug Design
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012/07/02 - 2012/07/05 Presentation of the poster "Understanding the reaction mechanism of L-asparaginase II – a computational study" at "X Girona Seminar on Theoretical and Computational Chemistry for the Modeling of Biochemical Systems: From Theory to Applications." held at Girona, Spain from 2 to 5 of July 2012.
Conference
 X Girona Seminar on Theoretical and Computational Chemistry for the Modeling of Biochemical Systems: From Theory to Applications.
Universitat de Girona, Spain
2012/05/09 - 2012/05/12 Presentation of the poster "Unveiling the Catalytic Mechanism of L-asparaginase II using Computational Methods" at "3PYCheM - 3rd Portuguese Young Chemists Meeting" held in Porto, Portugal from 9 to 11 May 2012.
Meeting
 3PYCheM - 3rd Portuguese Young Chemists Meeting
Sociedade Portuguesa de Química, Portugal
2011/06/08 - 2011/06/12 Presentation of the poster "Theoretical Insights on the Mechanism of L-asparaginase II" at "THEOBIO 2011 - 5th Symposium on Theoretical Biophysics", held at Funchal, Madeira, Portugal from 8 to 12 June 2011
Symposium
 THEOBIO 2011 - 5th Symposium on Theoretical Biophysics
Universidade do Porto Departamento de Química e Bioquímica, Portugal
2010/11/28 - 2010/11/30 Presentation of the poster "Unraveling the Enigmatic Mechanism of Asparaginase: a Key Enzyme in the Battle against Cancer" at the "2o Encontro Nacional de Química Terapêutica", held at Coimbra, Portugal from 28 to 30 of November 2010.
Conference
 2o Encontro Nacional de Química Terapêutica
Sociedade Portuguesa de Química, Portugal
2010/02/17 - 2010/02/19 Presentation of the poster "Theoretical and Computational Studies Addressed to Asparaginase" at "IJUP 2010 - 3rd Meeting of Young Researchers of U. Porto" held in Porto, Portugal from 17 to 19 February 2010.
Meeting
 IJUP 2010 - 3rd Meeting of Young Researchers of U. Porto
Universidade do Porto, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2012/02/22 - 2012/07/14 Bioinformática Mestrado em Bioquímica (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal

Mentoring / Tutoring

Topic Student name
2019/11/07 - 2019/11/28 Bioinformatics Cátia Soares
2019/11/04 - 2019/11/25 Bioinformatics Pedro Cipriano
2018/02/01 - 2018/08/31 Computational Biochemistry Beste Özaydin
Distinctions

Award

2012 Best Poster award - 3PYChem
Sociedade Portuguesa de Química, Portugal
2011 PhD Research Grant - reference FCT: SFRH/BD/78724/2011
Fundação para a Ciência e a Tecnologia, Portugal
2011 2nd place - Moléculas Mágnificas 2011
Universidade do Porto Departamento de Química e Bioquímica, Portugal