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I have a Ph.D. degree in Molecular Biosciences (2020/10/07) from Universidade Nova de Lisboa, Instituto de Tecnologia Química e Biológica António Xavier (ITQB-NOVA). I took a Master's of Applied Microbiology (2010/12/06) from Universidade de Lisboa, Faculdade de Ciências (FCUL) and Bachelor's in Microbiology (2009/07/30) from Universidade de Lisboa, Faculdade de Medicina (FMUL). I did a Management course, Programa Geral de Gestão (PGG) from Universidade Católica Portuguesa that gave me insights into marketing, organization, and strategy. I have a Project Management course from NOVA Doctoral School (2019/09/20 to 2019/09/30). I am author of 11 articles in International Scientific Journals (Google scholar total citations: 199, h-index: 8, i10-index: 7). I am author of a book chapter. I was awarded by EBEC conference for Best Poster. I received a PhD Student Fellowship (PD/BD/113985/2015) inserted in the Molecular Biosciences Program from ITQB-NOVA (PD/00133/2012) with the project entitled Exploring structural/functional relationship in Type II NADH:quinone oxidoreductases (from 2016 to 2020). I had a Research Fellowship with a project entitled Structural and functional investigation of type II NADH:quinone oxidoreductases (from 2012 to 2015). I also received a Bridge Fellow (Ref 010/BI/2015) from Programa INCENTIVO/EQB/LA0004/2014 do LA Oeiras (Oeiras) (from 2015-07 to 2015-12). During my Ph.D. studies I supervised three master students and five undergraduate students. I organized the European Biophysics Congress, EBSA2013 and the European Bioenergetics Conference, EBEC2014. I have been invited to present my work at international conferences through oral presentations and poster sessions. I was engaged in outreach activities such as Open Day and European Researchers Night. I have scientific experience in the areas of Natural sciences with emphasis on Biological Sciences specifically on Microbiology, on Biochemistry, on Biophysics and on Molecular Biology.
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Identification

Personal identification

Full name
Filipa Vaz Sena

Citation names

  • Sena, Filipa
  • Sena FV
  • Filipa V. Sena

Author identifiers

Ciência ID
6616-44DE-85CE
ORCID iD
0000-0002-7263-4665

Email addresses

  • filipasena@gmail.com (Professional)
  • fvsena@fc.ul.pt (Professional)

Telephones

Mobile phone
  • 918723628 (Personal)

Addresses

  • Praça 25 de Abril nr 7 2º direito, 1495-128 , Lisboa, Oeiras, Portugal (Personal)

Knowledge fields

  • Natural sciences - Biological Sciences - Microbiology
  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Biophysics
  • Natural sciences - Biological Sciences - Molecular Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Intermediate (B1)
Spanish; Castilian Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2) Beginner (A1)
French Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2) Beginner (A1)
Education
Degree Classification
2016/01/01 - 2020/10/07
Concluded
 Biociências Moleculares (Doutoramento)
Major in Bioquímica
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
"Exploring structural/functional relationship in Type II NADH:quinone oxidoreductases" (THESIS/DISSERTATION)
 Approved by unanimity
2012/01/02 - 2012/12/06
Concluded
 General Management Program-PGG (Pós-Graduação)
Major in Marketing
Universidade Católica Portuguesa, Portugal
 17
2009/09/02 - 2010/12/06
Concluded
 Microbiologia Aplicada (Mestrado)
Major in Microbiology
Universidade de Lisboa Faculdade de Ciências, Portugal
"Prevalence and genetic characterization of human immunodeficiency virus in patients treated at the Hospital in Cumura in Bissau" (THESIS/DISSERTATION)
 16
2005/10/02 - 2009/07/30
Concluded
 Microbiologia (Licenciatura)
Major in Chemistry, Biochemistry, Cellular Biology, Molecular Biology, Microbial Genetics, Parasitology, Virology, Bacteriology, Mycology, Clinical Microbiology, Biotechnology.
Universidade de Lisboa Faculdade de Medicina, Portugal
 14
Affiliation

Other Careers

Category
Host institution 		Employer
2011/03/01 - 2012/05/30 Técnico Superior (Técnico Superior) Laboratórios Vitória SA, Portugal
Projects

Grant

Designation Funders
2016/01/01 - 2020/05/31 Exploring structural/functional relationship in Type II NADH:quinone oxidoreductases
PD/BD/113985/2015
PhD Student Fellow
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Ongoing
2012/06/01 - 2015/12/31 Structural and functional investigation of type II NADH:quinone oxidoreductases.
info:eu-repo/grantAgreement/FCT/3599-PPCDT/100288/PT
Research Fellow
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
 Universidade do Algarve Faculdade de Ciências e Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Refojo, Patrícia N.; Sena, Filipa V.; Calisto, Filipa; Sousa, Filipe M.; Pereira, Manuela M.. "The plethora of membrane respiratory chains in the phyla of life". In Advances in Microbial Physiology, 331-414. Oeiras, Portugal: Elsevier, 2019.
    Published • 10.1016/bs.ampbs.2019.03.002
Conference poster
  1. Sena FV. "The key role of glutamate 172 in the mechanism of type II NADH:quinone oxidoreductase (NDH-2) of Staphylococcus aureus". Paper presented in 2017 Gordon Research Conferences on Bioenergetics Andover, U.S.A., 2017.
  2. Sena FV. "The presence of the Charge-Transfer Complex in Type 2 NADH:quinone oxidoreductase from Staphylococcus aureus limits flavin oxidation". Paper presented in 2017 Gordon Research Conferences on Bioenergetics Andover, U.S.A., 2017.
  3. Sena FV. "Quinone interaction on Type II NADH:quinone oxidoreductase from Staphylococcus aureus". Paper presented in EBEC 2016: 19th European Bioenergetics Conference, Riva del Garda, Italy, 2016.
  4. Sena FV. "Taxonomic profile of type II NADH:quinone oxidoreductases and evolutionary implications". Paper presented in 40th FEBS Congress, Berlin, Germany., 2015.
  5. Sena FV. "Type-II NADH:quinone oxidoreductase from Staphylococcus aureus has two distinct binding sites and is rate limited by quinone reduction". Paper presented in 10th European Biophysics Congress, Dresden, Germany, 2015.
  6. Sena FV. "Structural function conservation and evolution of Type-II NADH:quinone oxidoreductases". Paper presented in 2015 Gordon Research Conferences on Bioenergetics, Andover, U.S.A., 2015.
  7. Sena FV. "Exploring structure and function in Type-II NADH:quinone oxidoreductase from Staphylococcus aureus". Paper presented in 2015 Gordon Research Conferences on Bioenergetics, Andover, U.S.A., 2015.
  8. Sena FV. "Exploring structural/functional relationship in Type II NADH dehydrogenases". Paper presented in 18th European Bioenergetics Conference, Lisbon, Portugal., 2014.
  9. Sena FV. "The selectivity of type II NADH:quinone oxidoreductase for quinones – a docking study". Paper presented in 9th European Biophysics Congress, Lisbon, Portugal., 2013.
  10. Sena FV. "Investigating substrate interaction on Type II NADH:quinone oxidoreductase from Escherichia coli". Paper presented in 9th European Biophysics Congress, Lisbon, Portugal., 2013.
  11. Sena FV. "Quinone interaction on Type II NADH dehydrogenase – a molecular selectivity for different substrates". Paper presented in 9th European Biophysics Congress, Lisbon, Portugal., 2013.
  12. Sena FV. "Studies on protein/substrate interaction of Type II NADH:quinone oxidoreductase from Escherichia coli". Paper presented in 17th European Bioenergics Conference, Freiburg, Germany., 2012.
Journal article
  1. Filipa Calisto; Filipe M. Sousa; Filipa V. Sena; Patrícia N. Refojo; Manuela M. Pereira. "Mechanisms of energy transduction by charge translocating membrane proteins". Chemical Reviews (2021): https://pubs.acs.org/doi/10.1021/acs.chemrev.0c00830.
  2. Sena, Filipa V.; Sousa, Filipe M.; Oliveira, A. Sofia F.; Soares, Cláudio M.; Catarino, Teresa; Pereira, Manuela M.. "Regulation of the mechanism of Type-II NADH: Quinone oxidoreductase from S. aureus". Redox Biology 16 (2018): 209-214. http://dx.doi.org/10.1016/j.redox.2018.02.004.
    Published • 10.1016/j.redox.2018.02.004
  3. Stevanovic, Strahinja; Perdih, Andrej; Sencanski, Milan; Glišic, Sanja; Duarte, Margarida; Tomás, Ana; Sena, Filipa; et al. "In Silico Discovery of a Substituted 6-Methoxy-quinalidine with Leishmanicidal Activity in Leishmania infantum". Molecules 23 4 (2018): 772. http://dx.doi.org/10.3390/molecules23040772.
    Published • 10.3390/molecules23040772
  4. Sousa, Filipe M.; Sena, Filipa V.; Batista, Ana P.; Athayde, Diogo; Brito, José A.; Archer, Margarida; Oliveira, A. Sofia F.; et al. "The key role of glutamate 172 in the mechanism of type II NADH:quinone oxidoreductase of Staphylococcus aureus". Biochimica et Biophysica Acta (BBA) - Bioenergetics 1858 10 (2017): 823-832. http://dx.doi.org/10.1016/j.bbabio.2017.08.002.
    Published • 10.1016/j.bbabio.2017.08.002
  5. Marreiros, Bruno C.; Sena, Filipa V.; Sousa, Filipe M.; Oliveira, A. Sofia F.; Soares, Cláudio M.; Batista, Ana P.; Pereira, Manuela M.. "Structural and Functional insights into the catalytic mechanism of the Type II NADH:quinone oxidoreductase family". Scientific Reports 7 1 (2017): http://dx.doi.org/10.1038/srep42303.
    Published • 10.1038/srep42303
  6. Marreiros, Bruno C.; Calisto, Filipa; Castro, Paulo J.; Duarte, Afonso M.; Sena, Filipa V.; Silva, Andreia F.; Sousa, Filipe M.; et al. "Exploring membrane respiratory chains". Biochimica et Biophysica Acta (BBA) - Bioenergetics 1857 8 (2016): 1039-1067. http://dx.doi.org/10.1016/j.bbabio.2016.03.028.
    Published • 10.1016/j.bbabio.2016.03.028
  7. Marreiros, Bruno C.; Sena, Filipa V.; Sousa, Filipe M.; Batista, Ana P.; Pereira, Manuela M.. "Type II NADH:quinone oxidoreductase family: phylogenetic distribution, structural diversity and evolutionary divergences". Environmental Microbiology 18 12 (2016): 4697-4709. http://dx.doi.org/10.1111/1462-2920.13352.
    Published • 10.1111/1462-2920.13352
  8. Salewski, Johannes; Batista, Ana P.; Sena, Filipa V.; Millo, Diego; Zebger, Ingo; Pereira, Manuela M.; Hildebrandt, Peter. "Substrate–Protein Interactions of Type II NADH:Quinone Oxidoreductase from Escherichia coli". Biochemistry 55 19 (2016): 2722-2734. http://dx.doi.org/10.1021/acs.biochem.6b00070.
    Published • 10.1021/acs.biochem.6b00070
  9. Sena, Filipa V.; Batista, Ana P.; Catarino, Teresa; Brito, José A.; Archer, Margarida; Viertler, Martin; Madl, Tobias; Cabrita, Eurico J.; Pereira, Manuela M.. "Type-II NADH:quinone oxidoreductase from Staphylococcus aureushas two distinct binding sites and is rate limited by quinone reduction". Molecular Microbiology 98 2 (2015): 272-288. http://dx.doi.org/10.1111/mmi.13120.
    Published • 10.1111/mmi.13120
  10. Rosário, Ana Lúcia; Sena, Filipa V.; Batista, Ana P.; Oliveira, Tânia F.; Athayde, Diogo; Pereira, Manuela M.; Brito, José A.; Archer, Margarida. "Expression, purification, crystallization and preliminary X-ray diffraction analysis of a type II NADH:quinone oxidoreductase from the human pathogenStaphylococcus aureus". Acta Crystallographica Section F Structural Biology Communications 71 4 (2015): 477-482. http://dx.doi.org/10.1107/s2053230x15005178.
    Published • 10.1107/s2053230x15005178
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2018 Regulation of the mechanism of Type-II NADH: Quinone oxidoreductase from S. aureus Lisbon Biophysics IST 2018
Instituto Superior Técnico (Lisboa, Portugal)
2015/06 Exploring structure and function in Type-II NADH:quinone oxidoreductase from Staphylococcus aureus Gordon Research Conferences on Bioenergetics
Gordon Research Conferences (Andover, United States)
Distinctions

Award

2012 Poster Award
European Bioenergetics Conference (EBEC), Germany