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Dr. Lima obtained her BSc degree in Marine Biology and Biotechnology, from the School of Tourism and Maritime Technology of Leiria, in 2011. She continued her studies with a MSc in Pharmaceutical Biotechnology at the University of Coimbra, awarded in 2013. In 2015, she enrolled the Graduate Program Science for Development, launched in PALOP, and then joined Dr. Gozzelino's Lab at NOVA Medical School (NMS), in Lisbon, to pursue her PhD. During her training, she investigated how inflammatory compounds, released under pathologic conditions and linked to iron metabolism, prime to disease onset. Immune-mediated, infectious and neurodegenerative diseases, like Parkinson’s, have been the focus of her studies, which resulted in the publication 3 reviews and 2 research articles, of which 4 as open access and 3 with her as 1st author. Mentoring students and contributing to the development of their scientific competence are tasks accomplished by Dr. Lima since the beginning of her career. During her PhD, she trained 3 assistant researchers recruited to Dr. Gozzelino’s Lab to provide technical support. When referring to students, she officially co-supervised 2 BSc and 2 MSc theses. While obtaining her PhD in Molecular Biosciences, in 2021, she participated as team member in research fund applications attributed to Dr. Gozzelino's Lab by FCT, iNOVA4Health and Santander Totta. Two consecutive calls awarded to that laboratory by FNRS-The Excellence of Science Program secured her studies and post-doctoral fellowship from January 2022. Upon Dr. Gozzelino appointment as Rector of the Atlantic Technical University in Cape Verde, Dr. Lima showed her availability to lecture ocean science and, as such, to transfer the knowledge she acquired on marine biodiversity and health to her country of origin. In 2022, she started teaching also at NMS, joining the Faculty of the Biomedical Research Master Program. In April 2023, she was appointed as Head of the Flow Cytometry Facility, benefiting from a term-contract with NMS. In December 2023, she rejoined Dr. Gozzelino’s Lab as senior researcher, investigating the relationship between the severity of inflammatory diseases and iron metabolism.
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Identification

Personal identification

Full name
Illyane Sofia Martins Lima

Citation names

  • Lima, Illyane

Author identifiers

Ciência ID
651B-C655-74F1
ORCID iD
0000-0003-3082-7650

Knowledge fields

  • Natural sciences - Biological Sciences - Cell Biology

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2015/10/01 - 2021/12/14
Concluded
 Molecular Bioscience (Doutoramento)
Major in Inflammation and Neurodegeneration
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
"Heme/Iron-driven microglia polarization in Parkinson’s disease" (THESIS/DISSERTATION)
2018/09/24 - 2018/10/05
Concluded
 Felasa Animal Course, Function A + D (equivalent to former B category) (Diploma de especialização)
Instituto Gulbenkian de Ciência, Portugal
2013
Concluded
 Pharmaceutical Biotechnology (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
"Medicinal and aromatic plants of Cape Verde: characterization of volatile metabolites of endemic and native species" (THESIS/DISSERTATION)
 16
2011
Concluded
 Marine Biology and Biotechnology (Licenciatura)
Instituto Politécnico de Leiria Escola Superior de Turismo e Tecnologia do Mar de Peniche, Portugal
"Extracellular enzymatic activity from tributyltin resistant microorganisms" (THESIS/DISSERTATION)
 14
Affiliation

Science

Category
Host institution 		Employer
2023/12/01 - Current Postdoc (Research) Universidade NOVA de Lisboa NOVA Medical School, Portugal
2019/03/01 - Current Auxiliary Researcher (Research) Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2021/12/15 - 2023/04/17 Postdoc (Research) Universidade NOVA de Lisboa NOVA Medical School, Portugal

Others

Category
Host institution 		Employer
2023/03/18 - 2023/11/30 Head of Flow Cytometry Facility Universidade NOVA de Lisboa NOVA Medical School, Portugal
Universidade NOVA de Lisboa NOVA Medical School, Portugal
Projects

Grant

Designation Funders
2023 - Current The Impact of Climate Change on Infection-Triggered Anemia in Cape Verde
0000000345
Post-doc
Massachusetts Institute of Technology
Ongoing
2022/01/01 - 2023/04/17 Cell Death Regulation and Role in Infection and Inflammatory Diseases (CD-INFLADIS)
40007512
Post-doc
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Ongoing
2019/03/01 - 2023/04/17 MOlecular mechanisms of cellular DEath and Life decisions in Inflammation, Degeneration and Infection (MODEL-IDI)
30826052
PhD Student Fellow
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Ongoing

Contract

Designation Funders
2016/07/01 - 2020/06/30 NetDiamond: NEw Targets in DIAstolic heart failure: from coMOrbidities to persoNalizeD medicine
SAICTPAC/0047/2015
PhD Student Fellow
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade de Aveiro, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade NOVA de Lisboa NOVA Medical School, Portugal

Universidade do Porto Faculdade de Medicina, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference abstract
  1. Lemos, Marco F.L.; Lima, Illyane S.M.; da Fonseca, Kaori L.; Monteiro, Hugo R.; Esteves, Ana C.. "Extracellular enzymatic activity from tributyltin resistant microorganisms". Paper presented in Conference: European Biotechnology Congress, 2011.
    Accepted
Conference poster
  1. Pêgo, AC; Lima, Illyane; Martins, Gracelino; vujic, Maja; Gozzelino, Raffaella. "The cross-talk between immunity and eythropoiesis in malaria induced anemia: the role of HFE". Paper presented in European Iron Club 2024, 2024.
  2. Pêgo, Ana; Lima, Illyane; Gozzelino, Raffaella. "The dynamic interaction between inflammation and iron sensors in malaria-induced anemia". Paper presented in 9th Congress of the International BioIron Society, 2023.
  3. Pêgo, Ana; Lima, Illyane; Gozzelino, Raffaella. "The Role of the Necroptosis in Severe Malarial Anemia: Insights from RIPK1 Ablation Models.". Paper presented in The 9th BioIron Congress. Darwin, Australia. August 2023., 2023.
  4. Pêgo, Ana; Lima, Illyane; Gozzelino, Raffaella. "THE DYNAMIC INTERACTION BETWEEN INFLAMMATION AND THE IRON SENSOR HFE, IN SEVERE MALARIA-INDUCED ANEMIA". Paper presented in EHA- Hybrid Congress, 2023.
  5. Pêgo, Ana; Lima, Illyane; Spasic MV; Nai A; Silvestri Laura ; Gozzelino, Raffaella. "The dynamic interaction between inflammation and iron sensors in malaria-induced anemia.". Paper presented in European Hematology Association Research Conference 2022, Palermo (Sicily), 2022.
  6. Pêgo, Ana; Lima, Illyane; Martins G, Spasic ; Silvestri Laura ; Nai, A; Gozzelino, Raffaella. "The dynamic interaction between inflammation and iron sensors in malaria-induced anemia.". Paper presented in European Hematology Association 2022 Hybrid Congress, 2022.
  7. Lima, Illyane; Ana Pêgo; Ana Catarina Martins; Inês Sá Pereira; Gozzelino, Raffaella. "Heme/Iron-Driven Microglia Polarization in Parkinson’s Disease.". Paper presented in XLVII Annual Meeting of the Portuguese Society for Immunology, 2022.
  8. Ana pego; Lima, Illyane; Gozzelino, Raffaella. "The dynamic interaction between inflammation and erythropoiesis in malaria-induced anemia.". Paper presented in XLVII Annual Meeting of the Portuguese Society for Immunology., 2022.
  9. Gozzelino, Raffaella; Pêgo, Ana; Lima, Illyane. "Changes in erythropoiesis in malaria-induced anemia.". Paper presented in 25th Congress of the European Hematology Association, 2020.
  10. Gozzelino, Raffaella; Pêgo, Ana C. ; Lima, Illyane; Silvestri, Laura; Nai, Antonella. Corresponding author: Gozzelino, Raffaella. "Erythropoiesis in Malaria-induced Anemia". Paper presented in 25th Congress of the European Hematology Association, 2020.
  11. Raffaella Gozzelino; Illyane Lima; Ana Pêgo; Ana Catarina Martins; Inês Sá Pereira; Gracelino Martins; Antonino Kapitão. "Heme cytotoxicity in the brain: microglia polarization and neuronal damage". Paper presented in 24th Congress of the European Hematology Association, 2019.
  12. Lima, Illyane; Pêgo, Ana; Inês Sá Pereira; Gracelino Martins; Ana Catarina Martins; Antonino Kapitão; Gozzelino, Raffaella. "Heme cytotoxicity in the brain: microglia polarization and neuronal damage". Paper presented in Portuguese Glial Network IV Symposium, 2019.
  13. Lima, Illyane; Pêgo, Ana C. ; Sá Pereira, Inês; Martins, Gracelino; Martins, Ana Catarina; Kapitão, Antonino; Gozzelino, Raffaella. "Heme Cytotoxicity in the Brain: Microglia Polarization and Neuronal Damag". Paper presented in 24th Congress of the European Hematology Association, 2019.
  14. Illyane Lima; Ana Pêgo; Inés Sá Pereira; Ana Catarina Martins; Gracelino Martins; Antonino Kapitão; Raffaella Gozzelino. "Heme/Iron driven microglia polarization in Parkinson’s disease". Paper presented in Sociedade Portuguesa de Imunologia XLIV Annual meeting, 2018.
  15. Ana Catarina Martins; Illyane Lima; Inés Sá Pereira; Antonino Kapitão; Ana Pêgo; Gracelino Martins; Raffaella Gozzelino. "Inflammation-driven disruption of Iron homeostasis in Parkinson’s disease". Paper presented in TOLL 2018, Editing Innate Immunity, 2018.
  16. Martins, Ana Catarina; Lima, Illyane; Kapitão, Antonino; Pêgo, Ana C. ; Martins, Gracelino; Gozzelino, Raffaella. Corresponding author: Martins, Ana Catarina. "The Interplay Between Immunity and Brain: the Tole of Iron in Neurodegenerative Diseases". Paper presented in TOLL 2018, Editing Innate Immunity, 2018.
  17. Illyane Lima; Ana Catarina Martins; Raffaella Gozzelino. "Heme/Iron driven microglia polarization in Parkinson’s disease". Paper presented in Sociedade Portuguesa de Imunologia XLIII Annual meeting, 2017.
  18. Ana Catarina Martins; Illyane Lima; Antonino Kapitão; Raffaella Gozzelino. "Inflammation-driven disruption of Iron homeostasis in Parkinson’s disease". Paper presented in Sociedade Portuguesa de Imunologia XLIII Annual meeting, 2017.
  19. Ana Catarina Martins; Susana Ramos; Illyane Lima; Miguel P. Soares; Raffaella Gozzelino. "Inflammation-driven disruption of Iron homeostasis in Parkinson’s disease". Paper presented in Sociedade Portuguesa de Imunologia, XLII Annual meeting, 2016.
  20. Illyane Lima; Lígia Salgueiro; Carlos Cavaleiro. "Ethnopharmacological and compositional surveys on aromatic plants of Cape Verde. Native species: Hyptis pectinata and Cymbopogon citratus". Paper presented in Conferência do Centro de Estudos Farmacêuticos (CEF 2013), 2013.
  21. Illyane Lima; Lígia Salgueiro; Carlos Cavaleiro. "Ethnopharmacological and compositional surveys on aromatic plants of Cape Verde. Endemic species: Artemisia gorgonum and Satureja forbesii". Paper presented in Conferência do Centro de Estudos Farmacêuticos (CEF 2013), 2013.
  22. Monteiro, H.R.; da Fonseca K.L.; Lima I.S.M.; Campos D.M.G.; Cruz A.; Alves A.; Correia A.. "Bacterial diversity on Portuguese ports: TBT degrading bacteria". Paper presented in ETAC 6th World Congress/SETAC Europe 22nd Annual Meeting, 2012.
  23. Marco Lemos; Lima, Illyane; Lemos, Marco F.L.; Lima, Illyane S.M.; da Fonseca, Kaori L.; Monteiro, Hugo R.; Esteves, Ana C.; Hugo Monteiro. "Extracellular enzymatic activity from tributyltin resistant microorganisms". Paper presented in European Biotechnology Congress, 2011.
Journal article
  1. Pêgo, Ana Catarina; Lima, Illyane Sofia; Martins, Ana Catarina; Sá-Pereira, Inês; Martins, Gracelino; Gozzelino, Raffaella. "Infection vs. Reinfection: The Immunomodulation of Erythropoiesis". International Journal of Molecular Sciences 25 11 (2024): 6153. http://dx.doi.org/10.3390/ijms25116153.
    Published • 10.3390/ijms25116153
  2. Pêgo, Ana Catarina; Lima, Illyane Sofia; Gozzelino, Raffaella. "Addressing Inequality in the COVID-19 Pandemic in Africa: A Snapshot from Clinical Symptoms to Vaccine Distribution". COVID 4 2 (2024): 170-190. http://dx.doi.org/10.3390/covid4020014.
    Published • 10.3390/covid4020014
  3. Pêgo, Ana; Lima, Illyane; Spasic, Maja; Nai, Antonella; Silvestri, Laura; Gozzelino, Raffaella. "P1491: THE DYNAMIC INTERACTION BETWEEN INFLAMMATION AND THE IRON SENSOR HFE, IN SEVERE MALARIA-INDUCED ANEMIA". HemaSphere 7 S3 (2023): e73335c1. http://dx.doi.org/10.1097/01.hs9.0000972844.73335.c1.
    10.1097/01.hs9.0000972844.73335.c1
  4. Pêgo, Ana; Lima, Illyane; Gozzelino, Raffaella. "P1564: THE ROLE OF THE NECROPTOSIS IN SEVERE MALARIAL ANEMIA: INSIGHTS FROM RIPK1 ABLATION MODELS". HemaSphere 7 S3 (2023): e73133dd. http://dx.doi.org/10.1097/01.hs9.0000973132.73133.dd.
    10.1097/01.hs9.0000973132.73133.dd
  5. Martins, Ana Catarina; Lima, Illyane Sofia; Pêgo, Ana Catarina; Sá Pereira, Inês; Martins, Gracelino; Kapitão, Antonino; Gozzelino, Raffaella. "Pro-Inflammatory Priming of the Brain: The Underlying Cause of Parkinson’s Disease". International Journal of Molecular Sciences 24 9 (2023): 7949. http://dx.doi.org/10.3390/ijms24097949.
    10.3390/ijms24097949
  6. Lima, Illyane S.; Pêgo, Ana C.; Martins, Ana C.; Prada, Ana R.; Barros, João Tomás; Martins, Gracelino; Gozzelino, Raffaella. "Gut Dysbiosis: A Target for Protective Interventions against Parkinson’s Disease". Microorganisms 11 4 (2023): 880. http://dx.doi.org/10.3390/microorganisms11040880.
    10.3390/microorganisms11040880
  7. Lima, Illyane Sofia; Pêgo, Ana Catarina; Barros, João Tomas; Prada, Ana Rita; Gozzelino, Raffaella. "Cell Death-Osis of Dopaminergic Neurons and the Role of Iron in Parkinson's Disease". Antioxidants & Redox Signaling 35 6 (2021): 453-473. http://dx.doi.org/10.1089/ars.2020.8229.
    10.1089/ars.2020.8229
  8. Martins, Ana C.; Almeida, Joana I.; Lima, Illyane S.; Kapitão, Antonino S.; Gozzelino, Raffaella. "Iron Metabolism and the Inflammatory Response". IUBMB Life 69 6 (2017): 442-450. http://dx.doi.org/10.1002/iub.1635.
    10.1002/iub.1635
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/04/04 The Role of Ripk1 In Preventing Malaria-induced Neuroinflammation European Iron Club
(Toulouse, France)
2022/07/13 Heme/Iron-Driven Microglia Polarization in Parkinson's Disease European Iron Club Conference 2022
Mathematical Institute, University of Oxfor (Oxford, United Kingdom)
2019/05/05 Changes in gut microbiota: an early event in Parkinson’s disease. 8th Congress of the International BioIron Society.
BioIron Society (Heidelberg, Germany)
2019/05/05 Heme cytotoxicity in the brain: microglia polarization and neuronal damage. 8th Congress of the International BioIron Society
BioIron Society (Heidelberg, Germany)
2019/03/07 Ferroptosis in Parkinson’s disease 2nd Congress of the Excellence of Science
(Liege, Belgium)
2018/11/18 Heme/Iron driven microglia polarization in Parkinson’s disease 3rd PGCD meeting
(Oeiras, Portugal)
2017/11/15 Heme/Iron driven microglia polarization in Parkinson’s disease. 2nd PGCD meeting.
(Torres Vedras, Portugal)
2017/10/05 Heme/Iron driven microglia polarization in Parkinson’s disease CEDOC 2nd PhD meeting
(Lousã, Portugal)
2016/10/06 -Heme/Iron driven microglia polarization in Parkinson’s disease. CEDOC 1st PhD meeting
(Póvoa do Lanhoso, Portugal)
2016/04/07 Inflammation-driven disruption of iron homeostasis: a risk factor for the development of Parkinson’s disease European Iron Club
(Innsbruck, Austria)
2015/07 Medicinal and aromatic plants of Cape Verde: characterization of volatile metabolites of endemic and native species” Ciclo de debates académicos da Associação Jovens Investigadores Caboverdianos (AJIC)
Associação Jovens Investigadores Caboverdianos (AJIC) (Praia, Cape Verde)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/05/08 - 2023/05/12 FlxFlow This course will cover basic and advanced cytometry topics and comprise lectures and practical modules taught by national and international experts in the field. Cytometry applications will be offered at all levels, targeted at both beginners and advanced users, and will be taught on different instruments in hands-on sessions. This will be an international course that last editions received over 300 participants from Portuguese and from foreign academic and non-academic institutions. (2023/05/08 - 2023/05/12)
Workshop (Other)
 Universidade Nova de Lisboa Comprehensive Health Research Centre, Portugal

Fundação Champalimaud, Portugal

Instituto Gulbenkian de Ciência, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2021/03/05 - 2021/03/07 Erythropoiesis Control and Ineffective Erythropoiesis - From Bench to Bedside
Conference
2019/03/27 - 2019/03/29 5th Workshop on Dendritic Cell Biology: Anti-tumoral immunotherapy
Workshop
 5th Workshop on Dendritic Cell Biology: Anti-tumoral immunotherapy
Fundação Champalimaud, Portugal
2018/06/04 - 2018/06/07 19th biennial meeting for the Society for Free Radical Research International (SFRRI)
Conference
 19th biennial meeting for the Society for Free Radical Research International (SFRRI)
2017/10/16 - 2017/10/19 Principals and Applications of Flow Cytometry
Other
 1st FLxFlow Course- Principals and Applications of FLow Cytometry
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2016/05/26 - 2016/05/26 Landscapes on Lymphocyte Itineraries
Workshop
Fundação Champalimaud, Portugal
2016/04/20 - 2016/04/22 Brain-Body interactions Workshop
Workshop
Fundação Champalimaud, Portugal
2016/01/18 - 2016/01/22 Fundamentals and Applications in Flow Cytometry
Other
Instituto Gulbenkian de Ciência, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/11/17 ANTIOXIDANT AND ANTI-INFLAMMATORY POTENTIAL OF POLYPHENOLS AND DERIVED METABOLITES IN PARKINSON’S DISEASE
(Thesis) Main arguer
 Hugo Tainha Lopes (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/06/19 Identification of cholesteryl-hemiglutarate effects on murine vascular smooth muscle cells.
(Thesis) Main arguer
 Rita Silva (Other)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Association member

Society Organization name Role
2019/03 - Current International BioIron Society (IBIS)
2016 - Current Sociedade Portuguesa de Imunologia (SPI)

Committee member

Activity description
Role 		Institution / Organization
2022/11/01 - 2023/10/30 Post Doc committee Our purpose as PdC is to represent and support the specific interests of Postdocs/Early Career Research Fellows in the NMS context, promote a sense of community and contribute to a solid institutional environment. We also aim to back the professional development of all NMS postdocs, encourage them to take advantage of the activities and development opportunities offered by NMS through duty rotation, and by implementing the Research action plan and academic/scientific policies.
Member
 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Conference scientific committee

Conference name Conference host
2023/10/16 - 2023/10/20 1st NMS Research Week

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2023/10/09 - Current The session covered the basic principles and applications of flow cytometry. From fluorophores and panel design, instruments operation, required controls to statistical analysis and potential applications. NOVA Biomedical Research Master (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2021/07/17 - 2021/09/08 Applying for funding: essential tools for researchers. (Outros) Instituto Gulbenkian de Ciência, Portugal
2021/01/28 - 2021/03/31 Writing in the Sciences, by coursera. Writing in the Sciences
2021/01/18 - 2021/03/18 Writing in the Sciences Writing in the Sciences (Outros) Stanford Medicine, United States

Mentoring / Tutoring

Topic Student name
2020/02/01 - 2020/07/01 Brain aging: Mechanisms leading to neurodegeneration Pedro Dias
2019/02/01 - 2019/06/01 Heme/Iron Role in Microglia Polarization Patrícia Bernardo
2019/02/01 - 2019/06 Heme/Iron-driven Disruption of Neuronal Functionality Maria Araujo Vitoria
Distinctions

Other distinction

2016 Best Poster Presentation - Inflammation-driven