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Paloma Gonçalves is a PhD student in the HIV evolution, epidemiology and prevention research group at iMed.ULisboa, Faculdade de Farmácia da Universidade de Lisboa. She started her academic training back in 2015 at NOVA School of Science and Technology, where she graduated in biochemistry. In 2021, Paloma successfully completed her MSc in Biomedical Sciences at Instituto de Higiene e Medicina Tropical, for which she was recognized with the Scholarly and Scientific Merit Award Professor Doutor Manuel Pinto as the best Master student in the field. After finishing her academic training, she was selected for a fellowship at Faculty of Pharmacy (Lisbon) to work on a project called "Epidemiology, drug resistance and pathogenesis of HIV in Cape Verde: The Cape Verde HIV Cohort". Throughout her work, she acquired experience in a wide range of molecular biology techniques and bioinformatics tools used in the field of phylogenetic analysis, phylodynamics and evolution of RNA viruses; immunological assays, cell culture models and viral infection. In 2022, she was awarded a PhD fellowship from Fundação para a Ciência e Tecnologia. Her project focuses on the development of new spiro-ß-lactams as broad-spectrum host-directed drugs against RNA viruses. At the same time, she is integrated in a parallel project on drug resistance in neonates born from HIV-infected mothers in Tanzania and Mozambique. Paloma's work has been presented in six posters and one oral communication at national and international meetings and congresses. Moreover, the results of her work have been published in two scientific articles as co-author (Microbiology spectrum journal and International Journal of Molecular Sciences) and one as first author (AIDS journal).
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Identification

Personal identification

Full name
Paloma Gonçalves

Citation names

  • Gonçalves, Paloma

Author identifiers

Ciência ID
6415-95F4-6D51
ORCID iD
0000-0003-1009-6715
Researcher Id
AAU-2001-2021

Addresses

  • Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003, Lisboa, Lisboa, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Biochemistry
  • Medical and Health Sciences - Health Sciences - Infectious Diseases

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Intermediate (B1) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Education
Degree Classification
2022/05/04 - 2022/09/21
Concluded
 R2Value-Research to Value (Outros)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Madan Parque, Portugal
2021/10/19 - 2021/10/19
Concluded
 Formação - Atualização em Biossegurança: Laboratórios de nível 2 e 3 (Outros)
Major in Biossegurança
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/06/17 - 2021/07/02
Concluded
 Curso não conferente de grau: Pathogen Multiomics and Bioinformatics (Outros)
Major in Bioinformatics
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/09 - 2021/07
Concluded
 Ciências Biomédicas (Mestrado)
Major in Biomedicina
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
"Investigação da análise genética e funcional dos genes pol e env e caraterização da resposta de anticorpos neutralizantes em adultos infetados por VIH-1 em Moçambique" (THESIS/DISSERTATION)
 18/20 (thesis - 19/20)
2020/02/12 - 2020/02/12
Concluded
 II Curso Pós-Graduado de Actualização em Virologia - Coinfeções e comorbilidades associadas à infeção por HIV (Outros)
Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento, Portugal
2015/09 - 2018/06
Concluded
 Bioquímica (Licenciatura)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Investigação da caracterização da resposta de anticorpos em adultos infetados pelo VIH-1" (THESIS/DISSERTATION)
 15 (thesis 18/20)
Affiliation

Science

Category
Host institution 		Employer
2019/07 - 2019/09 Research Trainee (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/07 - 2018/12 Research Trainee (Research) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Others

Category
Host institution 		Employer
2021/06/01 - 2022/09/30 Research Fellow Egas Moniz Cooperativa de Ensino Superior CRL, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/09/20 - 2021/05/29 Curricular Internship(MSc) - Investigation of the genetic and functional analysis of pol and env genes and characterization of the neutralizing antibody response in HIV-1 infected adults in Mozambique Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/01/02 - 2018/04/30 Curricular Internship (BSc) - “Investigation of antibody response characterization in HIV-1 infected adults” Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2017/06 - 2017/07 Extracurricular Internship - Laboratory Technician Labocentro S.A. - Laboratório Análises Clínicas, Portugal
Labocentro S.A. - Laboratório Análises Clínicas, Portugal
Projects

Grant

Designation Funders
2021/06/01 - 2022/09/30 Epidemiology, drug resistance and pathogenesis of HIV in Cape Verde: the Cape Verde HIV Cohort
CVHIVCo
Research Fellow
Fundação para a Ciência e a Tecnologia

Aga Khan Foundation
Concluded

Other

Designation Funders
2019/07 - 2019/09 Neonatal HIV early infant diagnosis (EID) versus standard-of-care EID. Impact on infant health (LIFE)
RIA2016MC-165
Research Trainee
Ongoing
Outputs

Publications

Conference abstract
  1. Gonçalves, Paloma; Martin, Francisco; Patrícia Borges; Espírito Santo, Maria; Nuno Eduardo Moura dos Santos da Costa Taveira; MARCELINO, JOSÉ MARIA. "PO 8597 NEUTRALISING AND NON-NEUTRALISING ANTIBODIES RESPONSE IN HIV-1-INFECTED INDIVIDUALS FROM MOZAMBIQUE". Paper presented in Ninth EDCTP Forum. Clinical Research and sustainable development in sub-Saharan Africa: the impact of North-South partnerships, Lisbon, 2019.
    Published • 10.1136/bmjgh-2019-edc.161
  2. Borges, Patrícia; Marcelino, Rute; Calado, Rita; Martin, Francisco; Gonçalves, Paloma; Janeiro, Nuno; Neno, Miguel; et al. "Antibody neutralization and its determinants in HIV-1 infected patients from Portugal: implications for vaccine design and efficacy". Paper presented in 3rd International Congress of CiiEM - Research and Innovation in Human and Health Sciences, Costa da Caparica, 2019.
    Published • 10.1080/07853890.2018.1561831
Conference poster
  1. Gonçalves, Paloma; Cheila Rocha; Correia, Vanessa; Luís A. Santos; Rebelo-de-Andrade, Helena; Bártolo, Inês; Nuno G. Alves; et al. Corresponding author: Nuno Eduardo Moura dos Santos da Costa Taveira. "Novel spiro-ß-lactams as promising broad-spectrum, host-directed drugs for the treatment of respiratory RNA virus infections". Paper presented in 14th iMed.ULisboa Meeting, 2023.
  2. Gonçalves, Paloma; Menilita Santos; Silvania Leal; Moranguinho, Inês; MARCELINO, JOSÉ MARIA; Palladino, Claudia; Barreto, Jorge; Nuno Eduardo Moura dos Santos da Costa Taveira. Corresponding author: Nuno Eduardo Moura dos Santos da Costa Taveira. "HIV Diversity, Drug Resistance and Antibody Neutralization in Cape Verde". Paper presented in 1st Egas Moniz One Health Symposium, 2022.
  3. Gonçalves, Paloma; Silvania Leal; Vitor Pimentel; Pingarilho, Marta; Moranguinho, Inês; Menilita Santos; Palladino, Claudia; et al. "Characterization of HIV-1 and HIV-2 genetic diversity and drug resistance profile in infected patients from Cape Verde". Paper presented in ASM Microbe 22, 2022.
  4. Bártolo, Inês; Moranguinho, Inês; Gonçalves, Paloma; Francisco Martin; Borrego, Pedro; Américo J. S. Alves; Nuno G. Alves; et al. Corresponding author: Nuno Eduardo Moura dos Santos da Costa Taveira. "Spiro-ß-lactam BSS-730A presents potent activity against RNA respiratory viruses and HIV". Paper presented in ASM Microbe 22, Washington D.C, 2022.
  5. Silvania Leal; Pimentel, Victor; Pingarilho, Marta; Gonçalves, Paloma; Nuno Eduardo Moura dos Santos da Costa Taveira; Isabel Araújo; Parreira, Ricardo; Abecasis, Ana. "High prevalence of K103N in newly diagnosed HIV-1 patients from Cabo Verde suggests that NNRTIs should be withdrawn from first-line ARV regimens". Paper presented in XII Jornadas Científicas do IHMT, 2021.
  6. Borges, Patrícia; Marcelino, Rute; Calado, Rita; Martin, Francisco; Gonçalves, Paloma; Afonso, Cláudia; Badura, Robert; et al. "Antibody neutralization and its determinants in HIV-1 infected patients from Portugal: implications for vaccine design and efficacy". Paper presented in 3rd International Congress of CiiEM - Research and Innovation in Human and Health Sciences, 2018.
Journal article
  1. Gonçalves, Paloma; Barreto, Jorge; Menilita Santos; Silvania Leal; MARCELINO, JOSÉ MARIA; Abecasis, Ana; Palladino, Claudia; Nuno Eduardo Moura dos Santos da Costa Taveira. Corresponding author: Nuno Eduardo Moura dos Santos da Costa Taveira. "HIV-1 drug resistance and genetic diversity in people with HIV-1 in Cape Verde, 2019-2021". AIDS (2023): https://pubmed.ncbi.nlm.nih.gov/38349224/.
    Published
  2. Inês Bártolo; ines Moura; Paloma Gonçalves; Ana Rita Diniz; Pedro Borrego; Francisco Martin; Inês Figueiredo; et al. "High Instantaneous Inhibitory Potential of Bictegravir and the New Spiro-ß-Lactam BSS-730A for HIV-2 Isolates from RAL-Naïve and RAL-Failing Patients". International Journal of Molecular Sciences (2022): https://www.mdpi.com/1422-0067/23/22/14300.
    10.3390/ijms232214300
  3. Martin, F.; Marcelino, J.M.; Palladino, C.; Bártolo, I.; Tracana, S.; Moranguinho, I.; Gonçalves, P.; et al. "Long-Term and Low-Level Envelope C2V3 Stimulation by Highly Diverse Virus Isolates Leads to Frequent Development of Broad and Elite Antibody Neutralization in HIV-1-Infected Individuals". Microbiology Spectrum 10 6 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85144637463&partnerID=MN8TOARS.
    10.1128/spectrum.01634-22
Thesis / Dissertation
  1. "Análise genética e funcional dos genes pol e env e caracterização da resposta em anticorpos neutralizantes em adultos infetados por VIH-1 de Moçambique". Master, Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, 2021. https://run.unl.pt/handle/10362/129347.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2018/09/18 First author of the following conference abstract "Neutralizing and non-neutralizing antibodies response in HIV-1 infected individuals from Mozambique". Authors: Paloma Gonçalves, Francisco Martin, Patrícia Borges, Maria Espírito Santo, Nuno Taveira and José Marcelino The ninth Forum of the European & Developing Countries Clinical Trials Partnership
European & Developing Countries Clinical Trials Partnership (Lisboa, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2017/04/19 - 2017/04/19 I participated in the organization of scientific, technological and pedagogical experiments and demonstrations (Chemistry Department) at the EXPO FCT 2017 event. This event occurs annually and receives high school students who want to know the scientific and technological productions developed at NOVA School of Science and Technology. (2017/04/19 - 2017/04/19)
Exhibition (Member of the Organising Committee)
 Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/06/26 - 2023/06/26 First author of the following poster: Novel spiro-ß-lactams as promising broad-spectrum, host-directed drugs for the treatment of respiratory RNA virus infections. I attended this meeting whose main goal is to complement the training of iMed.ULisboa postgraduate students', stimulating the cross-fertilization between the areas of the Institute and the network between students and fellow researchers.
Meeting
 14th iMed.ULisboa Postgraduate Students Meeting
Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/11/03 - 2022/11/03 First author of the following poster: HIV Diversity, Drug Resistance and Antibody Neutralization in Cape Verde. This symposium offered an opportunity to deepen the networking on One Health related areas of intervention. In fact, a collaborative and multidisciplinary approach, cutting across boundaries of animal, human and environmental health is imperative, requesting from the scientists, policymakers, health professionals, and society, actions that improve health outcomes and well-being of humans, animals, plants and their shared environment.
Symposium
 1st Egas Moniz One Health Symposium
Centro de Investigação Interdisciplinar Egas Moniz, Portugal
2021/12/10 - 2021/12/10 Co-author of the following poster: "High prevalence of K103N in newly diagnosed HIV-1 patients from Cabo Verde suggests that NNRTIs should be withdrawn from first-line ARV regimens". Authors: Silvânia da Veiga Leal, Victor Pimentel, Marta Pingarilho, Paloma Gonçalves, Nuno Taveira, Isabel Inês Monteiro de Pina Araújo, Ricardo Parreira and Ana Barroso Abecassis
Congress
 XII Jornadas Científicas do IHMT
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2020/01/31 - 2020/01/31 I attended this symposium that brings together several national specialists to discuss current topics in the area by exhibiting posters and giving scientific presentations allusive to the area. This event is organized by professors and researchers at FFUL and iMed.ULisboa - together with LisbonPH.
Symposium
 2nd Symposium on Tuberculosis and Non-Tuberculous Mycobacteria Research in Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/07/15 - 2019/07/15 I attended this meeting whose main goal is to complement the training of iMed.ULisboa postgraduate students', stimulating the cross-fertilization between the areas of the Institute and the network between students and fellow researchers.
Meeting
 11th iMed.ULisboa Postgraduate Students Meeting and 4rd I3DU Meeting
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/12/12 - 2018/12/12 I attended this scientific event that promotes the presentation of oral communications and the exhibition of posters by the institution's PhD students. The scientific projects covered are integrated in the fields of medical microbiology, medical parasitology and international public health.
Congress
 IX Jornadas Científicas do IHMT
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2018/06/20 - 2018/06/22 Co-author of the following poster: "Antibody neutralization and its determinants in HIV-1 infected patients from Portugal: implications for vaccine design and efficacy". Authors: Patrícia Borges; Rute Marcelino; Rita Calado; Francisco Martin; Paloma Gonçalves; Claúdia Afonso; Robert Bandura; et al.
Congress
 3rd International Congress of CiiEM - Research and Innovation in Human and Health Sciences, 2018
Egas Moniz Cooperativa de Ensino Superior CRL, Portugal
Distinctions

Award

2022 Best pitch award in R2Value Nova.id.FCT
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021 School and Scientific Merit Award Professor Doutor Manuel Pinto (Best MSc student in the field of Biomedical Sciences)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Other distinction

2022 Individual FCT PhD Fellowship (2022)
Fundação para a Ciência e a Tecnologia, Portugal