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Ana Catarina Duarte obtained her BSc (2013) and MSc (2014) degrees in Biomedical Sciences from Universidade da Beira Interior (UBI). In February of 2021 she completed the Ph.D. in Biomedicine at UBI, with a work focused on the characterization of the expression and function of bitter taste receptors at the human blood-cerebrospinal fluid barrier. During the PhD, she was responsible for the supervision of younger students and lab management. She was also a member of the PhD Student Committee and participated in Animal Experimentation, Calcium Imaging, and Python and Data Science courses. Currently, she is member of the CICS-UBI Scientific Council. Ana Catarina Duarte is author of 17 articles (mean impact factor of 6.30) in journals indexed in Journal Citation Reports and 1 book chapter. In addition, has been part of the organizing committee of 2 national and 1 international meetings and has presented her work at several national and international scientific conferences (awarded with 5 travel grants). She was also awarded with the best joint paper in CICS-UBI Symposium in 2021. Enrolled in the lecture of Oncobiology subject to MSc degrees at UBI from 2016 to 2019. Her current work, at Guarda Polytechique Institute and CPIRN laboratory, focus in Medical and Health Sciences with emphasis on in vitro research (cell and tissue culture), and development of Biomaterials to replace animal-origin products in research.
Identification

Personal identification

Full name
Ana Catarina Duarte

Citation names

  • Duarte, Ana Catarina

Author identifiers

Ciência ID
6311-CC2F-7102
ORCID iD
0000-0002-5911-6521

Languages

Language Speaking Reading Writing Listening Peer-review
English Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Spanish; Castilian Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Education
Degree Classification
2015/09/01 - 2021/02/08
Concluded
Biomedicina (Doutoramento)
Major in Neurociências
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
"Characterization of bitter taste receptors expression and function in the human blood-cerebrospinal fluid barrier" (THESIS/DISSERTATION)
2019/03/19 - 2019/06/04
Concluded
Python & Ciência de Dados (Outros)
Universidade da Beira Interior, Portugal
17
2018/11/22 - 2018/11/23
Concluded
Practical Course on Calcium Imaging (Outros)
Universidade da Beira Interior, Portugal
2015/01/14 - 2015/02/17
Concluded
Animal Experimentation Course (C Category) (Outros)
Centro de Cirugía de Mínima Invasión Jesús Usón, Spain
2014
Concluded
Ciências Biomédicas (Mestrado integrado)
Universidade da Beira Interior, Portugal
"Bisphenol A effects in transthyretin and barrier integrity markers in the choroid plexus: implications in amyloid beta catabolism" (THESIS/DISSERTATION)
2013
Concluded
Ciências Biomédicas (Licenciatura)
Universidade da Beira Interior, Portugal
Affiliation

Science

Category
Host institution
Employer
2021/09/01 - Current Researcher (Research) Instituto Politécnico da Guarda Unidade de Investigação para o Desenvolvimento do Interior, Portugal
Instituto Politécnico da Guarda Unidade de Investigação para o Desenvolvimento do Interior, Portugal
2020/10/01 - 2021/06/30 Research Trainee (Research) Blood Reprogramming Technologies, Lda, Portugal
2017/06/02 - 2020/06/30 Researcher (Research) Universidade da Beira Interior, Portugal
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Projects

Contract

Designation Funders
2017 - 2020/06/30 ICON - Interdisciplinary Challenges On Neurodegeneration
CENTRO-01-0145-FEDER-000013
Research Fellow
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Concluded
Outputs

Publications

Book chapter
  1. Gonçalves, Isabel; Duarte, Ana Catarina; Quintela, Telma; Hubbard, Peter; Baltazar, Graça; Schwerk, Christian; Belin, Andrea; Tomás, Joana; Santos, Cecília R. A.. Corresponding author: Santos, Cecília R. A.. "Experimental Tools to Study the Regulation and Function of the Choroid Plexus". 2019.
    10.1007/978-1-4939-8946-1_13
Conference paper
  1. Santos, Cecília R. A.; Duarte, Ana Catarina; Quintela, Telma; Tomás, Joana; Gonçalves, Isabel. "Chemical sensing at the rat choroid plexus is regulated by sex hormones". Paper presented in XII Conference of the Iberian Association for Comparative Endocrinology (AIEC), Faro, 2019.
    Published
Journal article
  1. Duarte, Ana Catarina; Costa, Ana Raquel; Gonçalves, Isabel; Quintela, Telma; Preissner, Robert; Santos, Cecília R.A.. "The druggability of bitter taste receptors for the treatment of neurodegenerative disorders". Biochemical Pharmacology 197 (2022): 114915. http://dx.doi.org/10.1016/j.bcp.2022.114915.
    Accepted • 10.1016/j.bcp.2022.114915
  2. Ana Catarina Duarte; Sílvia Rodrigues; Andrea Luísa Fernandes Afonso; António Nogueira; P. Coutinho. "Antibiotic Resistance in the Drinking Water: Old and New Strategies to Remove Antibiotics, Resistant Bacteria, and Resistance Genes". Pharmaceuticals (2022): https://www.mdpi.com/1424-8247/15/4/393.
    Accepted • 10.3390/ph15040393
  3. Furtado, André; Mineiro, Rafael; Duarte, Ana Catarina; Gonçalves, Isabel; Santos, Cecília R.; Quintela, Telma. "The Daily Expression of ABCC4 at the BCSFB Affects the Transport of Its Substrate Methotrexate". International Journal of Molecular Sciences 23 5 (2022): 2443. http://dx.doi.org/10.3390/ijms23052443.
    Accepted • 10.3390/ijms23052443
  4. Telma Quintela; André Furtado; Ana C. Duarte; Isabel Gonçalves; Jihwan Myung; Cecília R.A. Santos. "The role of circadian rhythm in choroid plexus functions". Progress in Neurobiology 205 (2021): 102129-102129. https://doi.org/10.1016/j.pneurobio.2021.102129.
    10.1016/j.pneurobio.2021.102129
  5. Costa-Brito, Ana R.; Quintela, Telma; Gonçalves, Isabel; Duarte, Ana C.; Costa, Ana R.; Arosa, Fernando A.; Cavaco, José E.; Lemos, Manuel C.; Santos, Cecília R. A.. "The Choroid Plexus Is an Alternative Source of Prolactin to the Rat Brain". Molecular Neurobiology (2021): http://dx.doi.org/10.1007/s12035-020-02267-9.
    Published • 10.1007/s12035-020-02267-9
  6. Duarte, Ana C.; Furtado, André; Hrynchak, Mariya V.; Costa, Ana R.; Talhada, Daniela; Gonçalves, Isabel; Lemos, Manuel C.; Quintela, Telma; Santos, Cecília R.A.. "Age, Sex Hormones, and Circadian Rhythm Regulate the Expression of Amyloid-Beta Scavengers at the Choroid Plexus". International Journal of Molecular Sciences 21 18 (2020): 6813. http://dx.doi.org/10.3390/ijms21186813.
    Published • 10.3390/ijms21186813
  7. Furtado, André; Astaburuaga, Rosario; Costa, Ana; Duarte, Ana C.; Gonçalves, Isabel; Cipolla-Neto, José; Lemos, Manuel C.; et al. "The Rhythmicity of Clock Genes is Disrupted in the Choroid Plexus of the APP/PS1 Mouse Model of Alzheimer’s Disease". Journal of Alzheimer's Disease 77 2 (2020): 795-806. http://dx.doi.org/10.3233/jad-200331.
    Published • 10.3233/jad-200331
  8. Almeida-Santos, D.; Duarte, A. C.; Gonçalves, I.; Ferreira, Catarina L.; Ferrer, I.; Ishikawa, Hiroshi; Schwerk, Christian; Schroten, Horst; Santos, Cecília R. A.. "Cadaverine and Spermine Elicit Ca2+ Uptake in Human CP Cells via a Trace Amine-Associated Receptor 1 Dependent Pathway". Journal of Molecular Neuroscience (2020): http://dx.doi.org/10.1007/s12031-020-01684-8.
    Published • 10.1007/s12031-020-01684-8
  9. Duarte, Ana C.; Santos, José; Costa, Ana R.; Ferreira, Catarina L.; Tomás, Joana; Quintela, Telma; Ishikawa, Hiroshi; et al. "Bitter taste receptors profiling in the human blood-cerebrospinal fluid-barrier". Biochemical Pharmacology 177 (2020): 113954. http://dx.doi.org/10.1016/j.bcp.2020.113954.
    Published • 10.1016/j.bcp.2020.113954
  10. Duarte, Ana C.; Rosado, Tiago; Costa, Ana R.; Santos, José; Gallardo, Eugénia; Quintela, Telma; Ishikawa, Hiroshi; et al. "The bitter taste receptor TAS2R14 regulates resveratrol transport across the human blood-cerebrospinal fluid barrier". Biochemical Pharmacology 177 (2020): 113953. http://dx.doi.org/10.1016/j.bcp.2020.113953.
    Published • 10.1016/j.bcp.2020.113953
  11. Daniela Talhada; Ana Raquel Costa-Brito; Ana Catarina Duarte; Ana Raquel Costa; Telma Quintela; Joana Tomás; Isabel Gonçalves; Cecília Reis Alves Santos. "The choroid plexus: Simple structure, complex functions". Journal of Neuroscience Research (2020): https://doi.org/10.1002/jnr.24571.
    10.1002/jnr.24571
  12. Santos, C.R.A.; Duarte, A.C.; Costa, A.R.; Tomás, J.; Quintela, T.; Gonçalves, I.. "The senses of the choroid plexus". Progress in Neurobiology 182 (2019): 101680. http://dx.doi.org/10.1016/j.pneurobio.2019.101680.
    Published • 10.1016/j.pneurobio.2019.101680
  13. Tomás, Joana; Santos, Cecília R.A.; Duarte, Ana C.; Maltez, Maria; Quintela, Telma; Lemos, Manuel C.; Gonçalves, Isabel. "Bitter taste signaling mediated by Tas2r144 is down-regulated by 17ß-estradiol and progesterone in the rat choroid plexus". Molecular and Cellular Endocrinology 495 (2019): 110521. http://dx.doi.org/10.1016/j.mce.2019.110521.
    Published • 10.1016/j.mce.2019.110521
  14. Duarte, Ana. "Choroid plexus is an additional source of melatonin in the brain.". Journal of pineal research (2018): https://doi.org/10.1111/jpi.12528.
    10.1111/jpi.12528
  15. Duarte, Ana. "The choroid plexus as a sex hormone target: Functional implications". Frontiers in Neuroendocrinology (2016):
    10.1016/j.yfrne.2016.12.002
  16. Duarte, Ana. "Sex hormone decline and amyloid ß accumulation in the brain: revisiting the amyloid cascade hypothesis". Journal of Neuroendocrinology (2016):
    10.1111/jne.12432
  17. Costa AR; Marcelino H; Gonçalves I; Quintela T; Tomás J; Duarte AC; Fonseca AM; Santos CR. "Sex hormones protect against amyloid-beta induced oxidative stress in the choroid plexus cell line Z310.". (2016): http://europepmc.org/abstract/med/27328988.
    10.1111/jne.12404
  18. Quintela T; Marcelino H; Deery MJ; Feret R; Howard J; Lilley KS; Albuquerque T; et al. "Sex-Related Differences in Rat Choroid Plexus and Cerebrospinal Fluid: A cDNA Microarray and Proteomic Analysis.". (2016): http://europepmc.org/abstract/med/26606900.
    10.1111/jne.12340
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/12/15 Antibiotic resistance in waste waters: impact in human health Seminários de Outono
(Guarda, Portugal)
2019/11 Resveratrol transverses the human blood-CSF-barrier by a mechanism dependent on the bitter taste receptor TAS2R14 III International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship – Trends in Aging and Cancer
(Covilhã, Portugal)
2019/11 Circadian rhythmicity of amyloid beta scavengers in the choroid plexus. III International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship – Trends in Aging and Cancer
(Covilhã, Portugal)
2019/11 Bitter taste signalling in glioblastoma: an alternative pathway to tackle chemoresistance? III International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship – Trends in Aging and Cancer
(Covilhã, Portugal)
2019/11 Expression of Prolactin and Prolactin receptor in the Choroid Plexus. III International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship – Trends in Aging and Cancer
(Covilhã, Portugal)
2019/07 Are polyamines detected by the Trace Amine-Associated Recptor-1 in the human Choroid Plexus? XIV CICS-UBI Annual Symposium
(Covilhã, Portugal)
2019/07 Modulation of choroid plexus circadian clock alzheimer´s disease. XIV CICS-UBI Annual Symposium
(Covilhã, Portugal)
2019/06 Characterization of bitter taste receptors expression and function at the blood-cerebrospinal fluid barrier XVI Meeting of Portuguese Society for Neuroscience
Sociedade Portuguesa de Neurociências (Lisboa, Portugal)
2018/07 Bitter taste receptors expression and function in the choroid plexus: analysis of resveratrol as a stimulus. XIII CICS-UBI Annual Symposium
(Covilhã, Portugal)
2018/07 Are polyamines detected by the TAAR receptor family in the human Choroid Plexus? XII CICS-UBI Annual Symposium
(Covilhã, Portugal)
2015/11 Regulation of the expression of amyloid beta scavengers in response to amyloid beta insults during aging of the choroid plexus I International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship - Trends in Endocrinology and Neurosciences
(Covilhã, Portugal)
2015/07 Choroid plexus regulation of amyloid beta scavengers expression throughout life X Annual CICS-UBI Symposium
Universidade da Beira Interior - Centro de Investigação em Ciências da Saúde (Covilhã, Portugal)
2014/07 Bisphenol A effect in transthyretin expression and amyloid-beta clearance in rat choroid plexus IX Annual CICS-UBI Symposium
Universidade da Beira Interior - Centro de Investigação em Ciências da Saúde (Covilhã, Portugal)

Event organisation

Event name
Type of event (Role)
Institution / Organization
2021/10/01 - Current Member of the organizing committee of the Pint of Science Portugal 2022, an international science festival. (2021/10/01)
Festival (Member of the Organising Committee)
2018/07/05 - 2018/07/06 Member of the organizing committee of the XIII Annual CICS-UBI Symposium, 5-6th July 201 8, Covilhã - Portugal. (2018/07/05)
Symposium (Member of the Organising Committee)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2017/05/17 - 2017/05/20 Member of the organizing committee of the II International Congress in Health Sciences Research towards innovation and entrepreneurship: Trends in Biotechnology for Biomedical Applications, 17-20th May 2017 (2017/05/17)
Congress (Member of the Organising Committee)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2016/06/30 - 2016/07/01 Member of the organizing committee of the XI Annual CICS-UBI Symposium, 30th June - 1 st July 201 6, Covilhã - Portugal. (2016/06/30 - 2016/07/01)
Symposium (Member of the Organising Committee)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2021/01 - Current Journal of Neuroinflammation Springer Nature

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2018/09 - 2019/02 Oncobiologia (TP e PL) Bioquímica (Mestrado integrado) Universidade da Beira Interior, Portugal
2018/09 - 2019/02 Oncobiologia (TP e PL) Ciências Biomédicas (Mestrado integrado) Universidade da Beira Interior, Portugal
2017/09 - 2018/02 Oncobiologia (TP e PL) Bioquímica (Mestrado integrado) Universidade da Beira Interior, Portugal
2017/09 - 2018/02 Oncobiologia (TP e PL) Ciências Biomédicas (Mestrado integrado) Universidade da Beira Interior, Portugal
2016/09 - 2017/02 Oncobiologia (TP e PL) Bioquímica (Mestrado integrado) Universidade da Beira Interior, Portugal
2016/09 - 2017/02 Oncobiologia (TP e PL) Ciências Biomédicas (Mestrado integrado) Universidade da Beira Interior, Portugal
2016/09 - 2017/02 Oncobiologia (TP e PL) Química Medicinal (Mestrado integrado) Universidade da Beira Interior, Portugal
Distinctions

Award

2021 CICS-UBI Best Annual Joint Paper Award
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2020 Travel Award
Federation of European Neuroscience Societies, Belgium
2019 Travel Award
Federation of European Neuroscience Societies, Belgium
2019 Travel Award
Federation of European Neuroscience Societies, Belgium
2019 Scholarship
Sociedade Portuguesa de Neurociências, Portugal
2019 Research project award, 70th National Congress in Endocrinology, Braga, 2019.
Sociedade Portuguesa de Endocrinologia Diabetes e Metabolismo, Portugal
2018 Travel Award
Federation of European Neuroscience Societies, Belgium