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Rui Jorge Nobre has a degree in Biology from the Faculty of Sciences and Technology of the University of Coimbra (2002) and a PhD in Health Sciences and Technology, in the specialty of Biotechnology, from the Faculty of Pharmacy of the same University (2009). During his PhD he carried out research at the Portuguese Institute for Oncology (Portugal) and at the German Cancer Research Center (Germany), in the laboratory of the Nobel Prize of Medicine 2008 (Professor zur Hausen), being responsible for the discovery, isolation and characterization of a new oncogenic virus, Human Papillomavirus 108. He is the co-founder and scientific consultant of "infogene", a biotech company devoted to the development of non-invasive and early cancer detection assays, having been the Director of the R&D Department between 2008 and 2010. Since 2010 he has been a PhD researcher at the Center for Neurosciences and Cell Biology (CNC-CIBB) at the University of Coimbra (UC), where he develops gene transfer systems for the development of disease models and treatment of neurodegenerative diseases. Currently he is an Assistant researcher at the Interdisciplinary Research Institute at University of Coimbra (III/UC), Researcher at the Vectors, Gene and Cell Therapy Group (CNC-CIBB) and Coordinator of the "ViraVector", a national strategic research infrastructure with the aim of developing viral vectors and carrying gene transfer studies for the scientific community and other stakeholders. He is the author of several publications in international peer-reviewed journals, as research articles or scientific conference papers [45 in total] and has more than 90 scientific communications. In the last 5 years, he has authored 13 research articles in international peer-reviewed journals: 3 as first author (Nobre et al., Nucleic Acid therapy 2021, Nobre et al., Acta Neuropathologica C 2020, 2022), 2 as senior author (Brain 2020, J Mol Diagn 2020), and 6 papers as co-author. During this period, he was also the co-author of 18 scientific conference papers and the inventor of 2 patents in Biotechnology (already granted) and 2 international patent applications on the diagnosis and gene therapy of PolyQ disorders. One of the technologies (WO/2020/144611) was recently licensed to an international biotechnology company. To date, he has been PI or Co-PI of 9 research projects (approx. 900 thousand euros of funding). Between 2008 and 2010 he was the PI of two research projects with a global funding of 300 thousand euros, co-financed by the "BES Inovação award” and QREN program. In 2012, he obtained financial support from FCT to execute an exploratory project (NEU-NMC / 0331/2012) and then, his research work has been funded by the National Ataxia Foundation (USA) and "AFM-Télethon" (France). More recently, he has co-led research projects in collaboration with biotech companies in the area of gene therapy for PolyQ diseases (e.g. WAVE Life Sciences, Uniqure and PTC). Since 2011, he has also been actively involved in supervision. He has successfully supervised 3 undergraduate, 12 master's theses and supervise now 5 PhD theses. He was a jury of 19 master's dissertations (8 as main examiner) and 6 PhD theses and played an active role in the dissemination of science (participation in "Brain Awareness weeks", "Brain Gain initiative” and “Explorer-UC”). He is also Assistant professor of Gene therapy at the University of Algarve (since 2019 ) and visiting professor at the Biomedical Sciences at the Universidade Católica Portuguesa (since 2017). He was a fellow of several national and international foundations (e.g. FCT, Fundação Calouste Gulbenkian, NAF, AFM) and distinguished in recent years with several awards for science, innovation and entrepreneurship (e.g “Bluepharma's prize for the best PhD thesis in health sciences”, “Winner of the 6th edition of the Best Portuguese bio-entrepreneur", "Winner of the BES innovation national contest for the best innovative idea”, and others).
Identification

Personal identification

Full name
Rui Jorge Nobre

Author identifiers

Ciência ID
6218-4FA8-5643
ORCID iD
0000-0001-5816-2051

Email addresses

  • rui.jorge.nobre@gmail.com (Professional)
  • rui.nobre@cnc.uc.pt (Professional)

Addresses

  • Centro de Neurociências e Biologia Celular / Center for Neuroscience and Cell Biology, University of Coimbra, Rua Larga - Polo 1, 3004-504, COIMBRA, Coimbra, Portugal (Professional)

Websites

  • https://www.cibb.uc.pt/research/innovative-therapies/vectors-gene-cell-therapy/ (Professional)
  • https://www.cibb.uc.pt/scientific-platforms/viravector/ (Professional)

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Gene-based Diagnostics and Therapeutic Interventions
  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Natural sciences - Biological Sciences - Biology
  • Natural sciences - Biological Sciences - Cell Biology
  • Medical and Health Sciences - Medical Biotechnology - Gene-based Diagnostics and Therapeutic Interventions
  • Natural sciences - Biological Sciences - Molecular Biology
  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Medical and Health Sciences - Basic Medicine - Human Genetics
Education
Degree Classification
2017/11/10 - 2017/11/10
Concluded
Neurobiology of Disease Workshop: Gene Therapy to Address Unmet Needs in Neurology (Outros)
Society for Neuroscience, United States
2015/12/11 - 2015/12/11
Concluded
Workshop Applications of CRISPR to genetically tractable organisms (Outros)
Fundação Champalimaud, Portugal
2015/10/06 - 2015/10/14
Concluded
Wellcome Trust Advanced Course: Exome Sequencing (Outros)
Cambridge, United Kingdom
2015/09/30 - 2015/09/30
Concluded
Workshop On extracelular vesicles (Outros)
Universidade do Porto Faculdade de Farmácia, Portugal
2012/10/31 - 2012/10/31
Concluded
Biomedical Research (Outros)
Broad Institute, United States
2010/08/26 - 2010/09/04
Concluded
EMBO Practical course: Viral Vectors in Gene therapy - Applications & Novel production methods. (Outros)
EMBO Press, Germany
2010/07/15 - 2010/07/21
Concluded
Workshop Molecular Mechanisms in Neurodegeneration: From Molecule to Cures (Outros)
Harvard Medical School Portugal, Portugal
2010/05/17 - 2010/05/18
Concluded
Interactive workshop “Patents for researchers” (Outros)
Universidade de Coimbra, Portugal
2010/04/19 - 2010/04/30
Concluded
Course in Laboratory Animal Science (Outros)
Direcção-Geral de Alimentação e Veterinária, Portugal
2010/03/04 - 2010/03/05
Concluded
Workshop RNA therapeutics (Outros)
European Network of Excellence on Alternative Splicing EURASNET, United Kingdom

Harvard Medical School Portugal, Portugal
2009
Concluded
PhD in Sciences and Technology of Health (Biotechnology) (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
"Human papillomavirus and cervical cancer: novel phylogenetic and viral pathogenesis concepts" (THESIS/DISSERTATION)
Maximal final classification
2003
Concluded
Biology degree (scientific field) (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"N/A" (THESIS/DISSERTATION)
Classification: 16 in 20
Affiliation

Science

Category
Host institution
Employer
2019/07/01 - Current Auxiliary Researcher (Research) Universidade de Coimbra, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
(...)
2018/09/06 - 2019/06/30 Contracted Researcher (Research) Universidade de Coimbra, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017/09/01 - 2018/09/05 Invited Auxiliary Researcher (Research) Universidade de Coimbra, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
(...)
2014/10/01 - 2017/08/31 Postdoc (Research) Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013/10/01 - 2014/09/30 Invited Auxiliary Researcher (Research) Universidade de Coimbra, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
(...)
2010/09/01 - 2013/09/30 Postdoc (Research) Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
(...)
2004/10/01 - 2008/09/30 Researcher (Research) Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Coimbra Faculdade de Farmácia, Portugal
(...)
2003/11/01 - 2004/09/30 Research Trainee (Research) Instituto Português de Oncologia de Coimbra Francisco Gentil EPE, Portugal
Laboratório de Patologia Molecular do Centro Regional de Oncologia de Coimbra, Portugal

Positions / Appointments

Category
Host institution
Employer
2019/07/01 - Current Chief Executive Officer (CEO) Universidade de Coimbra, Portugal
ViraVector-Unidade de Produção de vetores virais para a transferência de genes, Portugal
2008/10/01 - 2010/08/31 Chief Scientific Officer (CSO) Infogene, Portugal
Infogene, Portugal
Projects

Grant

Designation Funders
2020 - Current Accelerating research & development for advanced therapies
Researcher
Innovative Health Initiative, Belgium
European Commission

European Federation of Pharmaceutical Industries and Associations
Ongoing
2018 - Current Bloqueio da neurodegenerescência por dispersão de silenciadores génicos
PTDC/BTM-SAL/29716/2017
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Associação para a Inovação e Desenvolvimento da FCT
Ongoing
2017 - Current Tackling CANcer STEM CELIs: a chanllenge anda n opportunity to advance in anti-cancer therapy
SAICTPAC/0022/2015
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Associação para a Inovação e Desenvolvimento da FCT
Ongoing
2016 - Current Visualização da terapia génica do sistema nervoso central
PTDC/BBB-NAN/0932/2014
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Associação para a Inovação e Desenvolvimento da FCT
2016 - Current Gene repair and repression strategies to alleviate Machado-Joseph disease
PTDC/NEU-NMC/0084/2014
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Associação para a Inovação e Desenvolvimento da FCT
2020 - 2020/11/30 Expedited validation and large-scale manufacture of a blowing device for collection with inactivation of samples for detection of SARS-CoV-2
Principal investigator
ViraVector-Unidade de Produção de vetores virais para a transferência de genes, Portugal

Infogene, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018 - 2019/06 Exosomes as gene delivery vectors for the treatment of Machado-Joseph disease/Spinocerebellar ataxia type 3
21163
Other
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
AFM-Téléthon
Concluded
2017 - 2018/09/05 BrainHealth 2020 - Detecção Precoce, Neuro-modulação e Terapias Avançadas para Neuropatologias
CENTRO-01-0145-FEDER-000008
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Centro 2020
2010 - 2017/08/31 Silencing Machado-Joseph disease trough the systemic route
SFRH/BPD/66705/2009
Post-doc Fellow
Associação para a Inovação e Desenvolvimento da FCT
Concluded
2014 - 2016/01 Silencing Machado-Joseph Disease/Spinocerebellar ataxia type 3 through the systemic route
.
Principal investigator
National Ataxia Foundation
Concluded
2012 - 2016 Dissecting the pathogenesis of Machado-Joseph disease in a new human disease model derived from induced pluripotent stem cells
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Associação para a Inovação e Desenvolvimento da FCT
Concluded
2013 - 2014/04 Silencing Machado-Joseph Disease through the systemic route
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Associação para a Inovação e Desenvolvimento da FCT
2004 - 2008 Unravelling the role of human papillomavirus in the development of cervical cancer: new phylogenetic perspective and new pathogenic concepts
SFRH/BD/19165/2004
PhD Student Fellow
Associação para a Inovação e Desenvolvimento da FCT

Contract

Designation Funders
2018 - Current Targeting mutant ATXN3 for the treatment of Spinocerebellar Ataxia 3 (SCA3) using allele-specific ASOs
.
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Wave Life Sciences
Ongoing
2019 - 2019/09 Targeting ATXN3 for the treatment of Spinocerebellar Ataxia 3 (SCA3) using AAV5 and an artificial microRNA
.
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
uniQure NV
Concluded
2010 - 2010/09 HPV home-kit – self-collection kit for HPV detection and other STD agents
.
Principal investigator
Infogene, Portugal
Quadro de Referência Estratégica Nacional - QREN

Fundo Europeu de Desenvolvimento Regional
Concluded
2008 - 2010/03 Desenvolvimento e validação clínica de um Kit de auto-colheita de células do colo do útero para rastreio do Papilomavírus Humano – HPV
.
Other
Banco Espírito Santo e Comercial de Lisboa
Concluded
2005 - 2006/03 Análise de Alterações Moleculares Relevantes para a Carcinogénese e Tratamento dos Tumores do Estroma Gastrointestinal
.
Researcher
Laboratório de Patologia Molecular do Centro Regional de Oncologia de Coimbra, Portugal
Novartis Oncology
Concluded
Outputs

Publications

Book
  1. Nobre, Rui Jorge. Descodificando o papel do papilomavírus humano no desenvolvimento do cancro do colo uterino: nova perspectiva filogenética e novos conceitos patogénicos. Bluepharma. 2011.
    Published
Book chapter
  1. Matos, Carlos A.; Carmona, Vítor; Vijayakumar, Udaya-Geetha; Lopes, Sara; Albuquerque, Patrícia; Conceição, Mariana; Nobre, Rui Jorge; Nóbrega, Clévio; de Almeida, Luís Pereira. "Gene Therapies for Polyglutamine Diseases". In Advances in Experimental Medicine and Biology, 395-438. Springer International Publishing, 2018.
    Published • 10.1007/978-3-319-71779-1_20
Conference abstract
  1. Afonso, Inês T.; Silva, Ana Carolina; Henriques, Carina; Lopes, Miguel; Baganha, Rafael; Lima, Patricia; Koppenol, Rebekah; et al. "mixCapAAV1/2 Vector: Distribution, Spreading and Tropism Analysis in Normal Mice". Paper presented in 24th Annual Meeting of the PortugueseSociety for Human Genetics (SPGH), Lisboa, 2020.
  2. Nobre, Rui Jorge; Saraiva, Joana; Susana, Paixão; Fusco, Clelia; Santana, Magda M; Miranda, Catarina Oliveira; Lorena, Petrella; et al. "A miRNA-based gene therapy approach to knock-down mutant ATXN3: Alleviation of Machado-Joseph disease phenotype in two mouse models upon two routes of administration". Paper presented in EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2019.
    Published
  3. Perfeito, Rita; Anjos, Vanessa; Marques, Andreia; Nobre, Rui Jorge; Manuel, Garrido; Christian, Scwamborn Jens; Pereira de Almeida, Luis Fernando Morgado. "Intersection of exosome secretion and autophagy on alpha-synuclein spreading profile in Parkinson’s disease cell models. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION". 2018.
    Published
  4. Albuquerque, Patrícia; Santana, Magda M; Nobre, Rui Jorge; Miranda, Catarina Oliveira; Lopes, Sara; Ribeiro-Rodrigues, TM; Girao, Henrique; Gomes, Célia; Pereira de Almeida, Luis Fernando Morgado. "Non-invasive brain delivery with hybrid extracellular vesicles (EVs) for therapy of Machado-Joseph disease (MJD), Journal of Extracellular Vesicles". 2018.
    Published
  5. Gaspar, Laetitia; Santana, Magda M; Perfeito, Rita; Albuquerque, Patrícia; Ribeiro-Rodrigues, Teresa M; Girao, Henrique; Nobre, Rui Jorge; Pereira de Almeida, Luis Fernando Morgado. "Optimization of a size-exclusion chromatography protocol to isolate plasma-derived extracellular vesicles for transcriptional biomarkers research, Journal of Extracellular Vesicles". 2018.
    Published
  6. Nobre, Rui Jorge; Saraiva, Joana; Fusco, Clelia; Paixão, Susana; Santana, Magda M; Petrella, Lorena; Sereno, José; et al. "Non-Invasively Silencing and Monitoring Machado-Joseph Disease. Molecular Therapy". 2018.
    Published
  7. Lopes, Sara; Nobre, Rui Jorge; Nobrega, Clévio; Lopes, Miguel; Matos, Carlos; Sanjana, Neville; Hsu, Patrick; et al. "TALEN and CRISPR Gene-Editing for Treatment of Machado-Joseph Disease, Molecular Therapy". 2018.
    Published
  8. Miranda, Catarina Oliveira; Marcelo, Adriana; Silva, TP; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Duarte, Sónia; et al. "Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph disease/spinocerebellar ataxia type-3, Human Gene Therapy". 2018.
    Published
  9. Nobre, Rui Jorge; Saraiva, Joana; Fusco, Clelia; Paixão, Susana; Santana, Magda M; Petrella, Lorena; Sereno, José; et al. "Non-invasive allele-specific silencing therapy and biomarkers for Machado-Joseph disease, Human Gene Therapy". 2018.
    Published
  10. Miranda, Catarina Oliveira; Nobre, Rui Jorge; Paiva, VH; Castelhano, João; Petrella, Lorena; Sereno, José; Castelo-Branco, Miguel; Pereira de Almeida, Luis Fernando Morgado. "Assessing cerebellar neurometabolic biomarkers by in vivo magnetic resonance spectroscopy in a transgenic mouse model of Machado-Joseph disease. HUMAN GENE THERAPY". 2018.
    Published
  11. Miranda, Catarina Oliveira; Marcelo, Adriana; Silva, TP; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Duarte, Sónia; et al. "Repeated transplantation of mesenchymal stromal cells in Machado-Joseph disease/Spinocerebellar ataxia type-3 mice can sustainably alleviate phenotypic symptoms. . EUROPEAN JOURNAL OF CLINICAL INVESTIGATION". 2018.
    Published
  12. Nobre, Rui Jorge; Saraiva, Joana; Fusco, Clelia; Paixão, Susana; Santana, Magda M; Sena-Esteves, Miguel; Pereira de Almeida, Luis Fernando Morgado. "Non-invasive AAV9-mediated silencing of mutant ataxin-3 alleviates motor and neuropathological deficits in a transgenic mouse model of Machado-Joseph disease, Human Gene Therapy". 2016.
    Published
Conference paper
  1. Coelho, Patricia; Fão, Lígia; Nobre, Rui Jorge; Pereira de Almeida, Luis ; Peça, João; Rego, Ana Cristina Carvalho. "Impact of SAPAP3 on mitochondrial function in Huntingtons disease". 2021.
    Published
  2. Perfeito, Rita; Anjos, Vanessa; Marques, Andreia; Nobre, Rui Jorge; Garrido, Manuel; Schwamborn, Jens; De Almeida, Luís. "Intersection of exosome secretion and autophagy on alpha-synuclein spreading profile in Parkinson’s disease cell models". 2019.
    10.3389/conf.fncel.2019.01.00015
  3. Lobo, Diana; Nobre, Rui Jorge; Miranda, Catarina; Pereira, Dina; Castelhano, João; Sereno, José; Castelo-Branco, Miguel; et al. "Blood-brain barrier dysfunction as a neuropathological feature in Machado-Joseph Disease: results from human and mouse samples". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), 2019.
    10.3389/conf.fncel.2019.01.00022
  4. Nobre, Rui; Saraiva, Joana; Paixão, Susana; Fusco, Cellia; Santana, Magda; Miranda, Catarina; Petrella, Lorena; et al. "Non-invasive and allele-specific silencing therapy for Polyglutamine disorders: the case of Machado-Joseph disease/Spinocerebellar ataxia type 3". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), 2019.
    Published • 10.3389/conf.fncel.2019.01.00007
Conference poster
  1. Silva, Ana Carolina; Lobo, Diana D; Henriques, Carina; Martins, Inês M; Lopes, Sara; Duarte, Sónia P; Wagner, Elizabeth; Nobre, Rui Jorge; de Almeida, Luis Pereira. "Antisense oligonucleotide mediated allele-specific silencing of mutant ATXN3 improves disease features in mouse models of Machado-Joseph disease". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  2. Perdigão P.; Matos C.; Lopes S.; Fernandes R.; Lopes M. M. ; Faro R.; Santana M.; Nobre R. J.; Pereira de Almeida L.. "Precise and scarless correction of ATXN3-CAG expansion by CRISPR/Cas9 for the generation of patient-derived MJD isogenic iPSC". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  3. Rafael Baganha; Miguel M. Lopes; Carina Henriques; David Rufino-Ramos; Luís Pereira de Almeida; Rui Jorge Nobre. "Development of Affinity-Based Purification Protocols for AAV Vectors targeting the Central Nervous System". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  4. Silva, Ana Carolina; Lobo, Diana D; Henriques, Carina; Martins, Inês M; Lopes, Sara M; Duarte, Sónia P; Wagner, Elizabeth; Nobre, Rui Jorge; de Almeida, Luis Pereira. "Allele-specific silencing of Machado-Joseph disease using antisense oligonucleotide therapeutics". Paper presented in 1st Symposium on Oligonucleotide Technologies and Therapeutics in Portugal (OTP2021), 2021.
  5. Henriques, Carina S.; Lopes, Miguel Monteiro; Albuquerque, Patricia Rosado; Rufino-Ramos, David; Gaspar, Laetitia; Lobo, Diana Duarte; Duarte, Sónia; et al. "Extracellular vesicles-associated AAVs as new gene delivery vectors for the treatment of brain disorders". Paper presented in 3rd BEB Day, 2019.
  6. Miguel M. Lopes; Jacques Paysan; José Rino; Sara M. Lopes; Rui J. Nobre; Luísa Cortes; Luís Pereira de Almeida. "Whole-Brain Analysis of Adeno-Associated Virus (AAV) Biodistribution with Single-Cell Resolution by Tissue Clearing and Light-Sheet Microscopy". Paper presented in 1st Annual Meeting in Pharmaceutical Sciences, 2019.
  7. Henriques, Carina S.; Lopes, Miguel Monteiro; Albuquerque, Patrícia Rosado; Rufino-Ramos, David; Gaspar, Laetitia; Duarte Lobo, Diana; Duarte, Sónia; et al. "Extracellular Vesicles-Associated AAVs as Gene Delivery Vectors for the Treatment of Brain Diseases". Paper presented in 5th GEIVEX Symposium, 2019.
  8. Barros, Maria Inês; Martins, Inês; Duarte, Sónia; Nobre, Rui Jorge; Simões, Ana Teresa; Miranda, Catarina Oliveira; Pereira de Almeida, Luis Fernando Morgado. "Assessing the putative role of mesenchymal stromal cells’ effectors in Machado-Joseph disease". Paper presented in 1st Annual Meeting in Pharmaceutical Sciences, 2019.
  9. Lopes, Sara M; Matos, Carlos Adriano; Conceição, André; Pena, Frederico; Lopes, Miguel Monteiro; Nobre, Rui Jorge; Nóbrega, Clévio; et al. "CRISPR-Cas9 systems targeting ATXN3 as therapeutic approaches for Machado-Joseph Disease". Paper presented in International Ataxia Research Conference (IARC 2019), 2019.
  10. Sara Lopes; Carlos Matos; André Conceição; Frederico Pena; Miguel Lopes ; Rui Nobre; Clévio Nóbrega; et al. "CRISPR-Cas9 Systems Targeting ATXN3 as Therapeutic Approaches for Machado-Joseph Disease". Paper presented in 2019 International Machado-Joseph Research Disease Conference, 2019.
  11. Lobo, Diana Duarte; Nobre, Rui Jorge; Miranda, Catarina Oliveira; Dina, Pereira; Castelhano, João; Sereno, José; Castelo-Branco, Miguel; Pereira de Almeida, Luis Fernando Morgado. "Blood-brain barrier dysfunction in Spinocerebellar ataxia type 3 (Machado-Joseph disease): results from mouse and human brain tissues". Paper presented in Society for Neuroscience meeting, 2019.
  12. Lopes, Miguel Monteiro; Paysan, Jacques; Rino, José; Lopes, Sara Monteiro; Nobre, Rui Jorge; Cortes, Luisa; Pereira de Almeida, Luis Fernando Morgado. "Whole-Brain Analysis of Adeno-Associated Virus (AAV) Biodistribution with Single-Cell Resolution by Tissue Clearing and Light-Sheet Microscopy". Paper presented in EMBO | EMBL Symposium: Seeing Is Believing – Imaging the Molecular Processes of Life, 2019.
  13. Marcelo, Adriana; Miranda, Catarina Oliveira; Nobre, Rui Jorge; Silva, T.; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; et al. "Sustainable phenotypic ameliorations in Machado-Joseph Disease/Spinocerebelar ataxia type-3 can be reached by repeated systemic administrations of mesenchymal stromal cells – and can be monitored through proton Magnetic Resonance Spectroscopy biomarkers". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), 2019.
  14. Nobre, Rui Jorge; Saraiva, Joana; Fusco, Clelia; Paixão, Susana; Santana, Magda M; Petrella, Lorena; Castelhano, João; et al. "Non-invasive allele-specific silencing therapy and biomarkers for Machado-Joseph disease". Paper presented in 26th Annual Congress of European Society of Gene and Cell Therapy, 2018.
  15. Miranda, Catarina Oliveira; Nobre, Rui Jorge; Paiva, Vitor H; Castelhano, João; Petrella, Lorena I; Sereno, José; Castelo-Branco, Miguel; Pereira de Almeida, Luis Fernando Morgado. "Assessing cerebellar neurometabolic biomarkers by in vivo Magnetic Resonance Spectroscopy in a transgenic mouse model of Machado-Joseph disease". Paper presented in 26th Annual Congress of European Society of Gene and Cell Therapy, 2018.
  16. Nobre, Rui Jorge; Saraiva, Joana; Fusco, Clelia; Paixão, Susana; Santana, Magda M; Petrella, Lorena; Castelhano, João; et al. "Non-Invasively Silencing and Monitoring Machado-Joseph Disease". Paper presented in The American Society of Gene & Cell Therapy meeting, 2018.
  17. Albuquerque, Patricia Rosado; Santana, Magda M; Nobre, Rui Jorge; Miranda, Catarina Oliveira; Lopes, Sara Monteiro; Ribeiro-Rodrigues, Teresa; Girao, Henrique; Gomes, Célia; Pereira de Almeida, Luis Fernando Morgado. "Non-invasive delivery with hybrid extracelular vesicles for therapy of Machado Joseph-disease". Paper presented in International Society for Extracellular Vesicles Annual Meeting, 2018.
  18. Santana, Magda M; Gaspar, Laetitia; Perfeito, Rita; Albuquerque, Patrícia; Ribeiro-Rodrigues, Teresa; Girao, Henrique; Nobre, Rui Jorge; et al. "Optimization of a size exclusion chromatography protocol to isolate plasma-derived extracelular vesicles for transcriptional biomarkers research". Paper presented in International Society for Extracellular Vesicles Annual Meeting, 2018.
  19. Miranda, Catarina Oliveira; Machado, Adriana; Silva, T.; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Duarte, Sónia; et al. "Repeated treatment with mesenchymal stromal cells sustainably alleviates Machado-Joseph Disease and Its Efficacy Can Be Monitored With Neurospectroscopic Biomarkers". Paper presented in 1st international symposium Secretome With]Out[ Borders, 2018.
  20. Nobre, Rui Jorge; Saraiva, Joana; Fusco, Clelia; Paixão, Susana; Santana, Magda M; Sena-Esteves, Miguel; Pereira de Almeida, Luis Fernando Morgado. "Non-invasive and allele-specific silencing of mutant ataxin-3 alleviates neuropathology and motor deficits of Machado–Joseph disease". Paper presented in SFN - Society for Neuroscience meeting, 2017.
  21. Nobre, Rui Jorge; Saraiva, Joana; Fusco, Clelia; Paixão, Susana; Santana, Magda M; Sena-Esteves, Miguel; Pereira de Almeida, Luis Fernando Morgado. "Non-invasive and allele-specific silencing of mutant ataxin-3 alleviates neuropathology and motor deficits of Machado-Joseph disease.". Paper presented in IARC 2017 Conference - 2nd International Ataxia Research Conference, 2017.
  22. Miranda, Catarina Oliveira; Machado, Adriana; Silva, T.; Barata, João; Pereira, Dina; Vasconcelos-Ferreira, Ana; Nobrega, Clévio; et al. "Repeated treatment with mesenchymal stromal cells sustainably alleviates Machado-Joseph Disease/Spinocerebellar ataxia type-3 through neuroprotection of GABAergic neurons". Paper presented in 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC), 2017.
  23. Miranda, Catarina Oliveira; Machado, Adriana; Silva, T.; Barata, João; Nobrega, Clévio; Duarte, Sónia; Nobre, Rui Jorge; et al. "Repeated systemic injection of mesenchymal stem cells sustainably alleviates motor impairments and mitigates neuropathology in Machado-Joseph disease". Paper presented in XV Meeting of the Portuguese Society for Neurosciences, 2017.
  24. Lopes, Sara Monteiro; Nobre, Rui Jorge; Nobrega, Clévio; Lopes, Miguel Monteiro; Matos, Carlos Adriano; Sanjana, Neville; Hsu, Patrick; et al. "TALEN and CRISPR gene-editing for treatment of Machado-Joseph disease". Paper presented in 2nd International Ataxia Research Conference (IARC 2017), 2017.
  25. Nobre, Rui Jorge; Saraiva, Joana; Fusco, Clelia; Paixão, Susana; Santana, Magda M; Sena-Esteves, Miguel; Pereira de Almeida, Luis Fernando Morgado. "Non-invasive AAV9-mediated silencing of mutant ataxin-3 alleviates motor and neuropathological deficits in a transgenic mouse model of Machado-Joseph disease". Paper presented in 24th Annual Congress of European Society of Gene and Cell Therapy, 2016.
  26. Perfeito, Rita; Anjos, Vanessa; Nobre, Rui Jorge; Garrido, Manuel; Pereira de Almeida, Luis Fernando Morgado. "Autophagy activation prevents alpha-synuclein secretion in exosomes". Paper presented in Annual Meeting – ISEV, 2016.
  27. Nobre, Rui Jorge; Saraiva, Joana; Fusco, Clelia; Paixão, Susana; Santana, Magda M; Sena-Esteves, Miguel; Pereira de Almeida, Luis Fernando Morgado. "Silencing Machado-Joseph disease trough the systemic route.". Paper presented in Sixth Ataxia Investigators Meeting (AIM), 2016.
  28. Petrella, Li; Sereno, José V; Miranda, Catarina; Nobre, Rui Jorge; Castelhano, João; Pereira de Almeida, Luis Fernando Morgado; Castelo-Branco, Miguel. "Evaluation of brain structures volumes on a transgenic mouse model of Machado-Joseph disease". Paper presented in VII Annual Meeting of IBILI, 2015.
  29. Mendonça, Liliana; Onofre, Isabel; Nóbrega, Clévio; Nobre, Rui Jorge; Pereira de Almeida, Luis Fernando Morgado. "Generation of gene-silenced human iPS-derived NSC for transplantation in Machado Joseph Disease". Paper presented in World conference on regenerative medicine, 2015.
  30. Albuquerque, Patrícia; Nobre, Rui Jorge; Pereira de Almeida, Luis Fernando Morgado. "Polyglutamine expansion in the human ataxin-3 protein changes the extracellular vesicles RNA and protein content". Paper presented in First Iberian meeting on extracelular vesicles, 2015.
  31. Onofre, Isabel; Mendonça, Nuno; Lopes, Sara; Nobre, Rui Jorge; Barbosa, Joana; Carreira, Isabel M; Carvalho, Lina; et al. "Characterization of a human Machado-Joseph Disease neuronal cell model derived from induced pluripotent stem cells". Paper presented in 9th Annual meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2015.
  32. Lopes, Sara; Nobre, Rui Jorge; Nobrega, Clévio; Sanjana, Neville; Cong, Le; Hsu, Patrick; Ran, Fei Ann; Zhang, Feng; Pereira de Almeida, Luis Fernando Morgado. "Gene editing strategies towards Machado Joseph disease". Paper presented in EMBO workshop: "Modern DNA concepts and tools for safe gene transfer and modification", 2015.
  33. Santana, Magda M; Nobrega, Clévio; Nobre, Rui Jorge; Miranda, Catarina Oliveira; Mendonça, Liliana; Sousa-Ferreira, Ligia; Simões, Ana Teresa; et al. "Gene therapy approaches to investigate pathogenesis and disease modifying strategies for neurodegenerative diseases". Paper presented in Showcasing Portuguese Pharma Science:Advances in Discovery, Development and Manufacturing. Hovione and MIT Portugal Pharma Science Symposium, 2014.
  34. Simões, Ana Teresa; Gonçalves, Nélio; Nobre, Rui Jorge; Duarte, Carlos Bandeira; Pereira de Almeida, Luis Fernando Morgado. "Orally-administered calpain inhibitor BDA-410 reduces ataxin-3 cleavage and alleviates neuropathology in a lentiviral mouse model of Machado-Joseph disease". Paper presented in NAF – National Ataxia Foundation – 5th Ataxia Investigators Meeting, 2014.
  35. Albuquerque, Patricia; Nobre, Rui Jorge; Pereira de Almeida, Luis Fernando Morgado. "POLYGLUTAMINE EXPANSION IN THE HUMAN ATAXIN3 PROTEIN CHANGES THE EXOSOMAL microRNA CONTENT OF NEURONAL CELLS". Paper presented in 2nd Geivex Symposium Extracellular vesicles: From the bench to the clinics, 2014.
  36. Simões, Ana Teresa; Gonçalves, Nélio; Nobre, Rui Jorge; Duarte, Carlos B.; Pereira de Almeida, Luis Fernando Morgado. "Orally-administered calpain inhibitor BDA-410 reduces ataxin-3 cleavage and alleviates neuropathology in a lentiviral mouse model of Machado-Joseph disease". Paper presented in XIII REunião da Sociedade Portuguesa de neurociências, 2013.
  37. Gradiz, R; Mamede, AC; Abrantes, AM; Carvalho, L.; Silva, HC; Alarcão, A; Mesquita, L.; et al. "Characterization and therapeutic trials in MIA PaCa-2 pancreas cancer cell line.". Paper presented in World Molecular Imaging Congress, In Molecular Imaging and Biology, 2012.
  38. Santos, AI; Carreira, BP; Nobre, Rui Jorge; Carvalho, CM; Araújo, IM. "Stimulation of neural stem cell proliferation by inhibition of phosphodiesterase 5". Paper presented in 8th FENS, 2012.
  39. Santos, AI; Carreira, BP; Nobre, Rui Jorge; Carvalho, CM; Araújo, IM. "Inhibition of phosphodiesterase 5 enhances neural stem cell proliferation". Paper presented in IV Spanish and Portuguese Meeting on Free Radicals, 2012.
  40. Gradiz, R; Carvalho, L.; Silva, H.; Nobre, Rui Jorge; Botelho, MF; Mota-Pinto, A. "MIA PaCa-2 pancreas cancer cell line phenotypic and genotypic characterization". Paper presented in European Pancreas Club Conference, 2012.
  41. Conceição, Mariana; Cardoso, AL; Chunting, Y; Nobre, Rui Jorge; Pedroso Lima, M; Swamy, M; Pereira de Almeida, Luis Fernando Morgado. "Non-viral silencing of Machado Joseph Disease through the systemic route". Paper presented in 8th FENS, 2012.
  42. Nobre, Rui Jorge; Herraez-Hernandez, Elsa; Fei, Jian-Wei; Cruz, Eugénia; Real, Odete; Langbein, Lutz; Kaden, Sylvia; et al. "Unraveling the role of common, rare and novel human papillomaviruses in the pathogenesis of cervical cancer". Paper presented in 16th International Charles Heidelberger Symposium on Cancer Research, 2010.
  43. Nobre, Rui Jorge; Pereira de Almeida, Luis Fernando Morgado. "Silencing Machado-Joseph disease through the systemic route". Paper presented in Workshop “Molecular Mechanisms in Neurodegeneration: From Molecule to Cures.", 2010.
  44. Nobre, Rui Jorge; Pereira de Almeida, Luis Fernando Morgado. "Silencing Machado-Joseph disease through the systemic route.". Paper presented in Advanced Symposium and EMBO Practical course: Viral Vectors in Gene therapy - Applications & Novel production methods, 2010.
  45. Herráez-Hernández, E.; Nobre, Rui Jorge; Langbein, L.; Kaden, S.; Grone, H.-J.; de Viliers, E-M. "HPV20E6 Oncoprotein Modifies Epithelial Differentiation and Induces Lipid Accumulation". Paper presented in 25th International Papillomavirus Conference, Clinical and Educational Workshop, 2009.
  46. Nobre, Rui Jorge; Herráez-Hernández, E.; Fei, J; Langbein, L; Kaden, S; Gröne, H.-J.; de Villiers, E.-M.. "HPV108E7, lacking the E6 gene, induces dysplasia in raft cultures". Paper presented in 25th International Papillomavirus Conference, Clinical and Educational Workshop, 2009.
  47. Nobre, Rui Jorge; Pereira de Almeida, Luis Fernando Morgado; Martins, Teresa. ". Cervical Cancer: factors modulating susceptibility and resistance to cancer development". Paper presented in IV Reunião do Centro de Neurociências e Biologia Celular da Universidade de Coimbra, 2006.
  48. Nobre, Rui Jorge; Prazeres, H; Real, O; Cruz, E.; Figueiredo, P.; Lacerda, M; Pereira de Almeida, Luis Fernando Morgado; Martins, Teresa. "Genotype spectrum of Human Papillomavirus infection in Portuguese population: detection of HPV type 53 and 67 in cervical cancer". Paper presented in 23rd International Conference and Clinical Workshop on Papillomavirus, 2006.
  49. Nobre, Rui Jorge; Prazeres, H; Coelho, T.; Cunha, S.; Cruz, E.; Figueiredo, P.. "Tipos do HPV detectados em lesões pré-neoplásicas e carcinomas do colo uterino provenientes de doentes do programa de rastreio da região centro". Paper presented in I Jornadas Oncológicas de Coimbra, 2004.
  50. Nobre, Rui Jorge; Prazeres, H; Cruz, E.; Figueiredo, P.. "Variantes moleculares do HPV 16 detectadas em carcinomas invasivos do colo uterino provenientes de doentes do programa de rastreio da região centro". Paper presented in I Jornadas Oncológicas de Coimbra, 2004.
  51. Nobre, Rui Jorge; Prazeres, H.; Cruz, E.; Figueiredo, P.. "High frequency of an european variant of the Human papillomavirus type 16 (E-T350G) in both CIN I and Invasive cervical cancer, in a series of patients from the central region of Portugal". Paper presented in International Symposium HPV and Cancer, 2004.
  52. Nobre, Rui Jorge; Prazeres, H.; Coelho, T.; Cunha, S.; Figueiredo, P.. "Espectro dos tipos de HPV numa série de doentes do programa de rastreio do cancro do colo uterino da região centro". Paper presented in IX Congresso Nacional de Anatomia Patológica, 2004.
  53. Nobre, Rui Jorge; Prazeres, H.; Cruz, E.; Figueiredo, P.. "Espectro das variantes do HPV 16 numa série de doentes com carcinoma invasivo do programa de rastreio do cancro do colo uterino da região centro". Paper presented in IX Congresso Nacional de Anatomia Patológica, 2004.
  54. Nobre, Rui Jorge; Prazeres, H.; Cruz, E.; Figueiredo, P.. "Molecular variants of Human papillomavirus type 16 in invasive cervical cancer in a series of patients from a screening program of the central region of Portugal". Paper presented in ”. 21st International Conference and Clinical Workshop on Papillomavirus, 2004.
  55. Prazeres, H; Nobre, Rui Jorge; Coelho, T.; Cunha, S.; Cruz, E.; Figueiredo, P.; Prazeres, H.. "Unexpected high prevalence of Human Papillomavirus type 16 in cervical intraepithelial neoplasia grade-1 in a series of patients from a screening program of the Central Region of Portugal". Paper presented in 21st International Conference and Clinical Workshop on Papillomavirus, 2004.
Journal article
  1. Nobre, Rui Jorge; Miranda C; Paiva VH; Duarte JV; Castelhano J; Petrella L; Sereno J; et al. Corresponding author: Pereira de Almeida L. "Cerebellar morphometric and spectroscopic biomarkers for Machado-Joseph Disease". Acta Neuropathologica communications (2022): https://www.doi.org/10.1186/s40478-022-01329-4.
    Open access • In press
  2. Nobre, Rui Jorge; Lobo, Diana D.; Henriques, Carina; Duarte, Sonia P.; Lopes, Sara M.; Silva, Ana C.; Lopes, Miguel M.; et al. "MiRNA-Mediated Knockdown of ATXN3 Alleviates Molecular Disease Hallmarks in a Mouse Model for Spinocerebellar Ataxia Type 3". Nucleic Acid Therapeutics (2021): http://dx.doi.org/10.1089/nat.2021.0020.
    Open access • 10.1089/nat.2021.0020
  3. Aguiar, Sandra Isabel; Dias, Joana N. R.; André, Ana Santos; Silva, Marta Lisete; Martins, Diana; Carrapiço, Belmira; Castanho, Miguel; et al. "Highly Specific Blood-Brain Barrier Transmigrating Single-Domain Antibodies Selected by an In Vivo Phage Display Screening". Pharmaceutics 13 10 (2021): 1598. http://dx.doi.org/10.3390/pharmaceutics13101598.
    10.3390/pharmaceutics13101598
  4. Marcelo, Adriana; Rosa, Ana; Alves-Cruzeiro, João; Ferreira, Benedita; Reis, Ricardo; Afonso, Inês; Henriques, Carina; et al. "Autophagy in Spinocerebellar ataxia type 2, a dysregulated pathway and a target for therapy". (2021):
    Under revision
  5. Gaspar, Laetitia S.; Santana, Magda M.; Henriques, Carina; Pinto, Maria M.; Ribeiro-Rodrigues, Teresa M.; Girão, Henrique; Nobre, Rui Jorge; Pereira de Almeida, Luís. "Simple and Fast SEC-Based Protocol to Isolate Human Plasma-Derived Extracellular Vesicles for Transcriptional Research". Molecular Therapy - Methods & Clinical Development 18 (2020): 723-737. http://dx.doi.org/10.1016/j.omtm.2020.07.012.
    10.1016/j.omtm.2020.07.012
  6. Nobre, Rui Jorge; Duarte Lobo, Diana; Oliveira Miranda, Catarina; Pereira, Dina; Castelhano, João; Sereno, José; Koeppen, Arnulf; Castelo-Branco, Miguel; Pereira de Almeida, Luís. "The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples". Acta Neuropathologica Communications 8 1 (2020): http://dx.doi.org/10.1186/s40478-020-00955-0.
    10.1186/s40478-020-00955-0
  7. Santana, Magda M.; Paixão, Susana; Cunha-Santos, Janete; Silva, Teresa Pereira; Trevino-Garcia, Allyson; Gaspar, Laetitia S.; Nóbrega, Clévio; et al. "Trehalose alleviates the phenotype of Machado–Joseph disease mouse models". Journal of Translational Medicine 18 1 (2020): http://dx.doi.org/10.1186/s12967-020-02302-2.
    10.1186/s12967-020-02302-2
  8. Lopes, Sara Monteiro; Faro, Rosário; Lopes, Miguel Monteiro; Onofre, Isabel; Mendonça, Nuno; Ribeiro, Joana; Januário, Cristina; Nobre, Rui Jorge; Pereira de Almeida, Luís. Corresponding author: Pereira de Almeida, Luís. "Protocol for the Characterization of the CAG Tract and Flanking Polymorphisms in Machado-Joseph Disease: Impact on Diagnosis and Development of Gene-Based Therapies". The Journal of Molecular Diagnostics (2020): http://dx.doi.org/10.1016/j.jmoldx.2020.03.003.
    Published • 10.1016/j.jmoldx.2020.03.003
  9. Silva, Ana C; Lobo, Diana D; Martins, Inês M; Lopes, Sara M; Henriques, Carina; Duarte, Sónia P; Dodart, Jean-Cosme; Nobre, Rui Jorge; Pereira de Almeida, Luis. "Antisense oligonucleotide therapeutics in neurodegenerative diseases: the case of polyglutamine disorders". Brain 143 2 (2019): 407-429. http://dx.doi.org/10.1093/brain/awz328.
    Published • 10.1093/brain/awz328
  10. Oliveira Miranda, Catarina; Marcelo, Adriana; Silva, Teresa Pereira; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Nóbrega, Clévio; et al. "Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease". Molecular Therapy 26 9 (2018): 2131-2151. http://dx.doi.org/10.1016/j.ymthe.2018.07.007.
    Published • 10.1016/j.ymthe.2018.07.007
  11. Marques, Ana Patrícia; Rosmaninho-Salgado, Joana; Estrada, Marta; Cortez, Vera; Nobre, Rui Jorge; Cavadas, Cláudia. "Hypoxia mimetic induces lipid accumulation through mitochondrial dysfunction and stimulates autophagy in murine preadipocyte cell line". Biochimica et Biophysica Acta (BBA) - General Subjects 1861 3 (2017): 673-682. http://dx.doi.org/10.1016/j.bbagen.2016.12.005.
    Published • 10.1016/j.bbagen.2016.12.005
  12. Onofre, Isabel; Mendonça, Nuno; Lopes, Sara; Nobre, Rui; de Melo, Joana Barbosa; Carreira, Isabel Marques; Januário, Cristina; Gonçalves, António Freire; de Almeida, Luis Pereira. "Fibroblasts of Machado Joseph Disease patients reveal autophagy impairment". Scientific Reports 6 1 (2016): http://dx.doi.org/10.1038/srep28220.
    Published • 10.1038/srep28220
  13. Costa, João T.; Mele, Miranda; Baptista, Márcio S.; Gomes, João R.; Ruscher, Karsten; Nobre, Rui J.; de Almeida, Luís Pereira; Wieloch, Tadeusz; Duarte, Carlos B.. "Gephyrin Cleavage in In Vitro Brain Ischemia Decreases GABAA Receptor Clustering and Contributes to Neuronal Death". Molecular Neurobiology 53 6 (2015): 3513-3527. http://dx.doi.org/10.1007/s12035-015-9283-2.
    Published • 10.1007/s12035-015-9283-2
  14. Simões, Ana Teresa; Gonçalves, Nélio; Nobre, Rui Jorge; Duarte, Carlos Bandeira; Pereira de Almeida, Luís. "Calpain inhibition reduces ataxin-3 cleavage alleviating neuropathology and motor impairments in mouse models of Machado–Joseph disease". Human Molecular Genetics 23 18 (2014): 4932-4944. http://dx.doi.org/10.1093/hmg/ddu209.
    Published • 10.1093/hmg/ddu209
  15. Santos, Ana I.; Carreira, Bruno P.; Nobre, Rui J.; Carvalho, Caetana M.; Araújo, Inês M.. "Stimulation of Neural Stem Cell Proliferation by Inhibition of Phosphodiesterase 5". Stem Cells International 2014 (2014): 1-13. http://dx.doi.org/10.1155/2014/878397.
    Published • 10.1155/2014/878397
  16. Jorge Nobre, Rui; Pereira de Almeida, Luis. "Gene Therapy for Parkinsons and Alzheimers Diseases: from the Bench to Clinical Trials". Current Pharmaceutical Design 17 31 (2011): 3434-3445. http://dx.doi.org/10.2174/138161211798072472.
    Published • 10.2174/138161211798072472
  17. Nobre, Rui Jorge; Cruz, Eugénia; Real, Odete; de Almeida, Luís Pereira; Martins, Teresa C.. "Characterization of common and rare human papillomaviruses in Portuguese women by the polymerase chain reaction, restriction fragment length polymorphism and sequencing". Journal of Medical Virology 82 6 (2010): 1024-1032. http://dx.doi.org/10.1002/jmv.21756.
    Published • 10.1002/jmv.21756
  18. Nobre, R. J.; Herraez-Hernandez, E.; Fei, J.-W.; Langbein, L.; Kaden, S.; Grone, H.-J.; de Villiers, E.-M.. "E7 Oncoprotein of Novel Human Papillomavirus Type 108 Lacking the E6 Gene Induces Dysplasia in Organotypic Keratinocyte Cultures". Journal of Virology 83 7 (2009): 2907-2916. http://dx.doi.org/10.1128/jvi.02490-08.
    Published • 10.1128/jvi.02490-08
  19. Nobre, Rui Jorge; de Almeida, Luís Pereira; Martins, Teresa C.. "Complete genotyping of mucosal human papillomavirus using a restriction fragment length polymorphism analysis and an original typing algorithm". Journal of Clinical Virology 42 1 (2008): 13-21. http://dx.doi.org/10.1016/j.jcv.2007.11.021.
    Published • 10.1016/j.jcv.2007.11.021
Newspaper article
  1. Vinhas, Ana Catarina; Ferreira, Ana Cristina; Henriques, Carina; Oliveira Miranda, Catarina; Silva, Carolina; Henriques, Daniel; Rufino-Ramos, David; et al. "Uma viagem rara", PÚBLICO, 2020, https://www.publico. pt/2020/02/28/ciencia/fotogaleria/viagem-rara-400481.
Thesis / Dissertation
  1. Nobre, Rui Jorge. "Unravelling the role of human papillomavirus in the development of cervical cancer: new phylogenetic perspective and new pathogenic concepts.". PhD, Universidade de Coimbra Faculdade de Farmácia, 2009.

Intellectual property

Patent
  1. Nobre, Rui Jorge. 2017. "PORTABLE DEVICE FOR THE STORAGE, TRANSPORT AND RECOVERY OF BIOLOGICAL MATERIAL".
    Granted/Issued
  2. Nobre, Rui Jorge; Pereira de Almeida, Luis Fernando Morgado; CALDEIRA MARTINS, Teresa Maria. 2013. "HUMAN PAPILLOMAVIRUS DETECTION KIT AND ASSAY".
Provisional application for patent
  1. 2020. "DOUBLE STRANDED RNA AND USES THEREOF".
  2. 2020. "OLIGONUCLEOTIDE PRIMERS FOR THE CHARACTERIZATION OF THE CAG TRACT AND MEASUREMENT OF MUTANT MRNA IN THE CONTEXT OF POLYGLUTAMINE DISORDERS".

Other

Dataset
  1. Nobre, Rui Jorge. Genoma completo do Papilomavírus humano tipo 108. GenBank.
Other output
  1. Associação Nacional de Estudantes de Biologia – AneBio.. Membro-fundador e Membro honorário da Associação Nacional de Estudantes de Biologia – AneBio.. 2003. Nobre, Rui Jorge.
Spin-off company
  1. 2008. Infogene. Biotecnologia.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/12/01 Gene therapy for Spinocerebellar Ataxia Portuguese Society for Neuroscience (Anual meeting)
(Coimbra, Portugal)
2021/09/17 Viral Vector for innovative therapies and ViraVector… everything you need to know! 3rd CIBB Innovative Therapies Retreat
(online event)
2021/05/25 Core facility ViraVector 3rd CIBB Neurosciences Retreat,
(online event)
2021/02 Allele-Specific Silencing Of Machado-Joseph Disease Using Antisense Oligonucleotide Therapeutics 20ª Reunião de Toxicologia. A Sociedade Portuguesa de Farmacologia
2021/02 Development of Single-Step Affinity Chromatography Protocols for the Purification of Adeno-Associated Viral Vectors 51st Annual Meating of the Portuguese Society of Pharmacology (SPF) / 39th Clinical Pharmacology Meating / 20th Toxicology Meating
(Lisbon, Portugal)
2021 MIXCAPAAV1/2 Vector: A Novel Gene Delivery System Distribution, Spreading And Tropism Analysis In Normal Mice 20ª Reunião de Toxicologia. A Sociedade Portuguesa de Farmacologia
2020/11/25 Whole-Brain Biodistribution Analysis of Adeno-Associated Virus (AAV) with Single-Cell Resolution by Tissue Clearing and Light-Sheet Microscopy Virtual Early Career European Microscopy Congress 2020
2020/11/20 Permanent Inactivation of the ATXN3 Gene: A Possible Therapeutic Approach for Machado-Joseph Disease 24th Annual Meeting of the Portuguese Society of Human Genetics
(Lisbon, Portugal)
2019/11/15 Extracellular vesicles-associated AAVs as gene delivery vectors for the treatment of brain disorders 1st Annual Meeting in Pharmaceutical Sciences
(Coimbra, Portugal)
2019/11/15 Blood-brain barrier dysfunction as a neuropathological feature in Machado-Joseph Disease 1st Annual Meeting in Pharmaceutical Sciences
Faculty of Pharmacy - University of Coimbra (Coimbra, Portugal)
2019/11/14 Allele-specific and Non-invasive AAV-based silencing of mutant ataxin-3 alleviates neuropathology and motor deficits in Spinocerebellar ataxia type 3 International Ataxia Research Conference
(Washington)
2019/11/07 A New Clearing Method for Whole-Brain Imaging with Single-Cell Resolution Spanish & Portuguese Advanced Optical Microscopy Meeting 2019 (SPAOM 2019)
(Coimbra, Portugal)
2019/11/07 Whole-Brain Analysis of Adeno-Associated Virus (AAV) Biodistribution with Single-Cell Resolution by Tissue Clearing and Light-Sheet Microscopy 2019 Spanish & Portuguese Advanced Optical Microscopy Meeting (SPAOM 2019)
(Coimbra, Portugal)
2019/11/07 Extracellular vesicles-associated AAVs as gene delivery vectors for the treatment of brain diseases 5th GEIVEX Symposium
(Granada, Spain)
2019/11 CRISPR-Cas9 systems targeting ATXN3 as therapeutic approaches for Machado-Joseph Disease International Ataxia Research Conference (IARC 2019)
(Washington, United States)
2019/11 miRNA expression profile of plasma-derived extracellular vesicles distinguishes Machado-Joseph Disease patients from controls 23rd Annual Meeting, Portuguese Society of Human Genetics
(Coimbra, Portugal)
2019/11 CRISPR-Cas9 Systems Targeting ATXN3 as Therapeutic Approaches for Machado-Joseph Disease 2019 International Machado-Joseph Research Disease Conference
(Washington DC., United States)
2019/10/10 Spectroscopic Biomarkers as a Way of Monitoring MSC Success in Promoting Neuropathological and Phenotypic Ameliorations in Machado-Joseph Disease Models 11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC)
(Lisboa, Portugal)
2019/10/09 Whole-Brain Analysis of Adeno-Associated Virus (AAV) Biodistribution with Single-Cell Resolution by Tissue Clearing and Light-Sheet Microscopy EMBO | EMBL Symposium: Seeing Is Believing – Imaging the Molecular Processes of Life
(Heidelberg, Germany)
2019/05/22 Repeated transplantation of mesenchymal stromal cells in Machado-Joseph Disease/Spinocerebelar ataxia type-3 can sustainably alleviate phenotypic symptoms and ameliorations can be monitored through magnetic resonance spectroscopy 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI)
(Coimbra, Portugal)
2019/02/06 Extracellular vesicles-associated AAVs as gene delivery vectors for the treatment of brain diseases XLIX Reunião da Sociedade Portuguesa de Farmacologia, XXXVII Reunião de Farmacologia clínica, XVIII Reunião de toxicologia
(Porto, Portugal)
2019/02 Disruption of blood-brain barrier in Machado-Joseph Disease XLIX Reunião Anual da Sociedade de Farmacologia
(Porto, Portugal)
2019 Permanent inactivation of the ATXN3 gene: A possible therapeutic approach for Machado-Joseph disease XVI Meeting of the Portuguese Society for Neuroscience (SPN 2019)
(Lisboa, Portugal)
2018/10/22 Non-invasive allele-specific silencing therapy and biomarkers for Machado-Joseph disease 26th Annual Congress of European Society of Gene and Cell Therapy
(Lausanne, Switzerland)
2018/05 Non-invasive brain delivery of hybrid extracellular vesicles for therapy of Machado-Joseph Disease (MJD) Annual Meeting ISEV2018
(Barcelona, Spain)
2018/02/05 AAV-based tools for the development of cellular and animal models of Machado-joseph disease XLVIII Reunião da Sociedade Portuguesa de Farmacologia / XXXVI Reunião de Farmacologia clínica / XVI/ Reunião de toxicologia
(Lisboa, Portugal)
2018/02/05 Cerebrovascular and blood-brain barrier impairments in Machado-Joseph Disease XLVIII Reunião da Sociedade Portuguesa de Farmacologia / XXXVI Reunião de Farmacologia clínica / XVI/ Reunião de toxicologia
(Lisboa, Portugal)
2018/02/05 Protocol for the characterization of CAG tract and flanking polymorphisms in PolyQ disorders: impact on the diagnosis and in the development of gene-based therapies XLVIII Reunião da Sociedade Portuguesa de Farmacologia / XXXVI Reunião de Farmacologia clínica / XVI/ Reunião de toxicologia
(Lisboa, Portugal)
2018/02/05 Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph disease XLVIII Reunião da Sociedade Portuguesa de Farmacologia / XXXVI Reunião de Farmacologia clínica / XVI/ Reunião de toxicologia
(Lisboa, Portugal)
2018 Exosomes: tiny vesicles with great potential for MJD treatment XII Spanish-Portuguese Conference on Controlled Drug Delivery - Tailoring drug delivery systems to the patients’ needs
(Coimbra, Portugal)
2018 Hybrid vesicles: a promising therapeutic approach for MJD 1st Meeting on Vesicular Biology
(Coimbra, Portugal)
2018 Non-invasive and allele-specific gene silencing therapy for MJD and a biomarker to monitor the therapeutic response XLVIII Reunião da Sociedade Portuguesa de Farmacologia / XXXVI Reunião de Farmacologia clínica / XVI/ Reunião de toxicologia
(Lisboa, Portugal)
2018 Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph Disease/Spinocerebelar ataxia type-3 AND therapeutic success can be monitored by H-MRS SPDMov 2018 Meeting – Genética nas Doenças do Movimento
(Curia, Portugal)
2018 Tailoring gene editing strategies for the treatment of Machado-Joseph disease Portuguese Society of Movement Disorders (SPDMov 2018)
(Curia, Portugal)
2017/09/30 TALEN and CRISPR gene-editing for treatment of Machado-Joseph disease 2nd International Ataxia Research Conference (IARC)
(Pisa, Italy)
2017/05/25 Non-invasive silencing of mutant ataxin-3 alleviates motor and neuropathological deficits in a transgenic mouse model of Machado-Joseph disease Congresso Nacional da Sociedade Portuguesa de Neurociências (SPN)
(Braga, Portugal)
2017/03/17 Silencing Spinocerebellar Ataxia Type 3 trough the systemic route Congresso Nacional da Sociedade Portuguesa das Doenças do Movimento (SPDMov)
(Ofir, Portugal)
2017/02/02 Silencing MJD trough the systemic route XLVII Reunião da Sociedade Portuguesa de Farmacologia / XXXV Reunião de Farmacologia clínica / XVI Reunião de toxicologia
(Coimbra, Portugal)
2017 Gene editing strategies for Machado-Joseph disease XLVII Portuguese Society of Pharmacology Annual Meeting
(Coimbra, Portugal)
2016/11/18 Non-invasive and viral-mediated gene therapy for Machado-Joseph disease (MJD) BRAIN WITHOUR BORDERS
(Coimbra, Portugal)
2016/11/10 Non-invasive and viral-mediated silencing of mutant ataxin-3 alleviates motor and neuropathological deficits in a transgenic mouse model of Machado-Joseph disease . 20ª Reunião Anual da Sociedade Portuguesa de Genética Humana (SPGH)
(Coimbra, Portugal)
2016/02/05 Silencing Machado-Joseph disease trough the systemic route XLVI Reunião da Sociedade Portuguesa de Farmacologia / XXXIV Reunião de Farmacologia clínica / XV Reunião de toxicologia
(Porto, Portugal)
2016/02/04 Autophagy activation prevents alpha-synuclein secretion in exosomes XLVI Reunião Anual da Sociedade Portuguesa de Farmacologia
(Porto, Portugal)
2015/10 Generation of gene-silenced human iPS-derived NSC for transplantation in Machado Joseph Disease World conference on regenerative medicine
(Leipzig, Germany)
2015/09/30 Activating autophagy prevents alpha-synuclein secretion in exosomes First Iberian Meeting on Extracellular Vesicles
(Porto, Portugal)
2014/05/20 Everything you need to know about human papillomavirus (HPV) and cervical cancer Conferências em Oncobiologia
ICBAS/FFUP (Porto, Portugal)
2012/03/01 Do viruses cause cancer? IV Jornadas Nacionais de Genética e Biotecnologia
UTAD (Vila Real, Portugal)
2011/05/22 Tudo, ou quase tudo, o que precisa de saber acerca do Papilomavírus humano Congresso dos Técnicos de Anatomia Patológica
(Espinho, Portugal)
2011/05/09 Papilomavírus e Cancro do colo do útero: novo conceito de filogenia patogénica e viral Congresso internacional EUROGIN
(Lisboa, Portugal)
2010/12/03 Empreendedorismo em Saúde: uma nova forma de inovar em Medicina XX ENEM
(Portimão, Portugal)
2010/04/13 Empreendedorismo na área da saúde 3º Fórum de empreendedorismo da ESEnfC
(Coimbra, Portugal)
2010/03/27 Descodificando o papel dos novos tipos de HPV no desenvolvimento do Cancro do Colo do Útero II Simpósio Microdiag
(Leiria, Portugal)
2010/01/26 Descodificando o papel dos novos tipos de Papilomavírus Humano: perspectiva filogenética e novos conceitos de patogénese 4th Cervical Cancer Prevention Week
(Porto, Portugal)
2009/04/25 Descodificando o papel do Papilomavírus Humano no desenvolvimento do cancro do colo uterino X Jornadas de Biologia Aplicada
(Braga, Portugal)
2009/03/30 Human papillomavirus detection Kit Healthcare Biotech Forum
(Roma, Italy)
2009/01/29 Human papillomavirus detection Kit i-techpartner Growth Academy
(Coimbra, Portugal)
2008/06/17 Diagnostic Kit for complete genital Human papillomavirus genotyping The Medtech Forum
(Coimbra, Portugal)
2008/01/30 Diagnostic Kit for Genital Human Papillomavirus typing Idea Spring 2008 – MIT program
Biocant (Cantanhede, Portugal)
2007/12/21 Complete genotyping of mucosal Human papillomavirus in Portuguese population using a novel PCR-RFLP methodology and an original algorithm Encontro anual do Centro de Neurociências e Biologia Celular 2007
(Coimbra, Portugal)
2006 Patologia molecular dos GISTS : Experiência dos Hospitais de Aveiro, Leiria, Viseu, Centro Hospitalar de Coimbra e IPO de Coimbra 2ª Reunião Nacional de GISTs - Tumores do Estroma Gastrointestinal
(Évora, Portugal)
2004/10/30 Técnicos de Anatomia Patológica - Tecnologias do Futuro VI Congresso Técnico de Anatomia Patológica
(Pombal, Portugal)
2004/10/13 Molecular Diagnosis of Human Papillomavirus: our experience in Formalin-fixed Paraffin-embedded Cervical Tissues 3rd International Symposium HPV and Cancer
(Lisboa, Portugal)
2004/02/07 Faringo-amigdalites Agudas por EHGA nos Primeiros 3 anos de Vida VI Reunião da Secção de Pediatria Ambulatória da Sociedade Portuguesa de Pediatria/III Reunião da Secção de Pediatria do Hospital Distrital de Pombal
(Pombal, Portugal)
2003/12/19 Variantes do vírus do papiloma humano tipo 16 presentes em Carcinomas Invasivos do Colo Uterino Encontro de Estudantes de Oncobiologia
(Coimbra, Portugal)
2003/12/08 Characterization of human papillomavirus type 16 variants in invasive cervical cancer paraffin-embedded I Congresso Ibérico de Estudantes de Biologia/ III Congresso Nacional de Estudantes de Biologia
(Évora, Portugal)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2021 - Current Towards Clinical Translation of an AAV-based silencing strategy for therapy of Machado-Joseph disease
Co-supervisor
Ciências Farmacêuticas (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2021 - Current Enhanced AAV vector toolkit for the generation of novel animal models and therapeutic strategies for polyglutamine diseases
Co-supervisor
Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2020 - Current Development of an AAV-Mediated Allele-Specific microRNA-Based Therapy For Machado-Joseph Disease
Supervisor
Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2020 - Current Overcoming the major roadblocks for successfully AAV-based gene therapy in CNS
Supervisor
Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2013/01 - Current Exosomes as biomarkers and gene delivery vectors for neurodegenerative disorders
Co-supervisor
Ciências e Tecnologia Farmacêutica (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2020/07 - 2022/02 Selection of Purification Methods and AAV Serotypes for CNS Transduction
Supervisor of Beatriz Sofia Leal da Silva
Biotecnologia Farmacêutica (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2019/09 - 2020/10 Development of Single-step Affinity Chromatography Protocols for the Purification of Adeno-Associated Viral Vectors
Supervisor of Rafael Baganha
Biotecnologia Farmacêutica (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2018/09 - 2019/10 Application of innovative and minimally invasive methods for cancer detection in a population context
Supervisor of Sara da Graça Marques Pereira
Biotecnologia Farmacêutica (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2018/07 - 2019/09 Allele-specific silencing of Machado-Joseph disease using Antisense oligonucleotide therapy
Supervisor of Ana Carolina Pinheiro da Silva
Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017/09 - 2018/10 Modified-Exosomes as gene delivert vectors for the treatment of Machado-Joseph Disease
Supervisor of Carina Santos Henriques
Biologia Molecular e Genética (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2016/09 - 2017/10 Is the blood-brain barrier compromised in Machado-Joseph disease?
Co-supervisor of Diana Lobo
Genética Molecular e Biomedicina (Master)
Universidade Nova de Lisboa, Portugal
2016/09 - 2017/09 A novel AAV-based mouse model of Machado-Joseph Disease
Supervisor of Miguel Monteiro Lopes
Investigação Biomédica (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2015/09 - 2016/09 Non invasive viral gene therapy for Machado Joseph Disease
Co-supervisor of Joana Saraiva
Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2015/09 - 2016/09 RNA silencing of Machado-Joseph disease using AAV9: intracranial injections versus intravenous injection
Supervisor of Clelia Fusco
Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/05 - 2016/06 Silenciamento da Doença de Machado-Joseph através do uso do vector adeno-associado do tipo 9 (AAV9)
Supervisor of Ana Cláudia Miquelino Basílio
Ciências Biomédicas (Degree)
Universidade do Algarve, Portugal
2014/02 - 2014/06 Design and validation of a set of primer pairs for measuring Ataxin-3 mRNA expression by quantitative real-time polymerase chain reaction
Co-supervisor of Joana Saraiva
Bioquímica (Degree)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013/01 - 2013/07 Characterization of the spectrum of HPV in São Tomé e Príncipe
Co-supervisor
Genética e Biotecnologia (Degree)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2011/09 - 2012/08 In vitro blood-brain barrier models to predict the permeation of gene-therapy vectors into the brain
Co-supervisor of Patrícia Rosado Albuquerque
Ciências Biomédicas (Master)
Universidade do Algarve, Portugal

Event organisation

Event name
Type of event (Role)
Institution / Organization
2004/10/30 - Current Organização de workshop intitulado “Técnicos de Anatomia Patológica – Tecnologias do Futuro” para um grupo de técnicos de Anatomia Patológica, durante o VI Congresso de Técnicos de Anatomia Patológica. Pombal, (2004/10/30)
Workshop (Co-organisor)

Event participation

Activity description
Type of event
Event name
Institution / Organization
2011 - Current Desde 2011: Participação activa no acompanhamento de rotações laboratoriais de alunos do Mestrado em Biologia Celular e Molecular da FCTUC, do Mestrado de Biotecnologia Farmacêutica da Faculdade de Farmácia da Universidade de Coimbra e do Programa Doutoral em Biologia Experimental e Biomedicina do CNC.
Other
Acompanhamento de rotações laboratoriais
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007/07 - Current Participação no programa “Ciência Viva” supervisionando alunos do ensino secundário no âmbito das actividade: “Os Vírus Causam Cancro?!”, realizada no Laboratório de Patologia Molecular do Centro Regional de Oncologia de Coimbra, SA
Other
Ciência Viva - “Os Vírus Causam Cancro?!”
Laboratório de Patologia Molecular do Centro Regional de Oncologia de Coimbra, Portugal
2006/09 - Current Participação no programa “Ciência Viva” supervisionando alunos do ensino secundário no âmbito das actividade: “Os Vírus Causam Cancro?!”, realizada no Laboratório de Patologia Molecular do Centro Regional de Oncologia de Coimbra, SA
Other
Ciência Viva - “Os Vírus Causam Cancro?!”
Laboratório de Patologia Molecular do Centro Regional de Oncologia de Coimbra, Portugal
2006 - Current Supervisão, ensino e acompanhamento de alunos do programa Doutoral do Centro de Neurociências e Biologia celular (CNC) da Universidade de Coimbra, no âmbito do programa e rotações laboratoriais. IPOCFG,EPE, Coimbra,
Other
Supervisão, Ensino e Acompanhamento de alunos
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2005/09 - Current Participação no programa “Ciência Viva”, orientando alunos do ensino secundário no âmbito da actividade intitulada “Análise do ADN tumoral para previsão da resposta ao tratamento do Cancro”, realizada no Laboratório de Patologia Molecular do Centro Regional de Oncologia de Coimbra, SA
Other
Ciência Viva - “Análise do ADN tumoral para previsão da resposta ao tratamento do Cancro”
Laboratório de Patologia Molecular do Centro Regional de Oncologia de Coimbra, Portugal
2004/04 - Current Supervisão do treino laboratorial de um grupo de técnicas do Instituto de Anatomia Patológica da Faculdade de Medicina da Universidade de Coimbra, na aprendizagem de técnicas de biologia molecular.
Other
Treino Laboratorial
Universidade de Coimbra Instituto de Anatomia Patológica, Portugal
2019/03/01 - 2019/03/29 Participação activa na Brain Awareness week 2019¿, que decorreu de 1 a 29 de Março de 2019, como comunicador de ciência a alunos do ensino pré-escolar. Actividade organizada pelo Gabinete de Comunicação de Ciência do CNC.
Other
Brain Awareness week 2019
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2021/10/21 Gene editing technologies to Machado-Joseph disease
Thesis Member
Sara Monteiro Lopes (PhD)
2020/01/09 The role of ageing in polyglutamine-induced neurodegeneration. A study in Machado-Joseph disease models
Thesis Member
Dina Maria da Silva Rodrigues Pereira (PhD)
Universidade de Coimbra, Portugal
2020 Improving ¿-retrovirus and lentivirus gene therapy vectors
(Thesis) Arguer
Ana Oliveira (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2016/07/27 Dissecting the pathogenesis of Machado-Joseph Disease in a new human disease model derived from induced pluoripotent stem cells
Thesis Member
Isabel Maria dos Santos Onofre (PhD)
Universidade de Coimbra, Portugal
2016/02/16 Non viral silencing of Machado-Joseph disease trough the sytemic route
Thesis Member
Mariana Oliveira da Conceição (PhD)
Universidade de Coimbra, Portugal
2015/05/18 Detecção do Vírus do Papiloma Humano por PCR em tempo real: Relevância para Medicina Legal
(Thesis) Main arguer
Daniela Tavares de Sousa (Master)
Universidade Nova de Lisboa, Portugal
2014/04/11 New approaches for the diagnosis of Human papillomavirus infection: relevance for clinical practice and câncer prevention
(Thesis) Main arguer
Ana Gradíssimo (PhD)
Universidade Nova de Lisboa, Portugal
2014/04/06 Custo-efetividade da utilização de um teste farmacogenético para o alopurinol em doentes portugueses diagnosticados com gota
(Thesis) Main arguer
Mauricio Alves Araujo (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2012/12 In vitro blood-brain barrier models to predict the permeation of gene therapy vectors into the brain
Thesis Member
Patricia Alexandra Rosado Albuquerque (Master)
Universidade do Algarve, Portugal
2012/11/23 Genetic markers of HPV infection and cervical cancer: clinical utility
(Thesis) Main arguer
licenciada Joana Patrícia Costa Ribeiro (Master)
Universidade do Porto, Portugal
2012/10/02 Tecnologias de Sequenciação do Genoma
(Thesis) Main arguer
Herlander Daniel Silva (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal

Association member

Society Organization name Role
2003 - Current Associação Nacional de Estudantes de Biologia – AneBio Membro-fundador e Membro honorário
2001 - 2002 Presidente do Núcleo de Estudantes de Biologia/AAC – NEB/AAC Presidente

Committee member

Activity description
Role
Institution / Organization
2001 - 2003 Membro do Conselho do Departamento de Zoologia (Universidade de Coimbra)
Member
Universidade de Coimbra, Portugal

Mentoring / Tutoring

Topic Student name
2019 - Current Explorer - Jovens Empreendedores Steve Ferreira
Distinctions

Award

2019 3rd BEB/BluePharma award
Bluepharma, Portugal
2017 2nd BEB/BluePharma award
Bluepharma, Portugal
2017 Trampoline Grant
AFM-Téléthon, France
2017 Bronze award: EIT health DPhil PhD transition Fellowship
2014 Research seed money Grant
National Ataxia Foundation, United States
2011 Bluepharma's prize 2010 - best portuguese PhD thesis in health sciences (in biennium 2008-2011)
2010 Winner of the national prize "Programa de Apoio à Investigação Clinica 2010"

Other distinction

2018 Best Oral Communication
2017 Best work in basic sciences
2017 Best Oral Communication in Clinical Research
2016 Best Oral Communication in Clinical Research
2015 Best Oral Comunication
2015 2nd Best poster at World conference on regenerative medicine
2008 "Entrepreneur of the Year" finalist, as founder of Infogene, a start-up company specialized in the development of innovative products/services for the screening of cancer.
Associação Nacional de Jovens Empreendedores, Portugal
2007 Winner of the BES innovation national contest in the “Health, Personal Care and Attendance” category, for developing an innovative self-collection kit to screen the Human papillomavirus.
Banco Espírito Santo e Comercial de Lisboa, Portugal
2007 Winner of the BES innovation national contest for the best innovative idea.
2006 Winner of the 6th edition of the Best portuguese bio-entrepreneur
2004 Honorable Mention (Milte Prize) for the oral presentation: “Nobre R et al. Faringo-amigdalites Agudas por EHGA nos Primeiros 3 anos de Vida”. Reunião Nacional de Pediatria, 2004.
2002 Bolsa de Mérito Escolar / Merit Fellowship
2001 Bolsa de Mérito Escolar / Merit Fellowship
2000 Bolsa de Mérito Escolar / Merit Fellowship
1999 Bolsa de Mérito Escolar / Merit Fellowship
1998 Bolsa de Mérito Escolar / Merit Fellowship