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In 2017, Catarina Guerreiro Simões began her Bachelor’s degree (BSc) in Molecular and Cellular Biology at NOVA School of Science and Technology, NOVA University Lisbon. Throughout her studies, she gained comprehensive knowledge across various aspects of biology, focusing on cellular and molecular levels. As part of her academic curriculum, Catarina conducted a research project titled “Screening of a transposon library in Staphylococcus aureus for the study of lysozyme resistance” at the Molecular Microbiology of Bacterial Pathogens Lab, UCIBIO, aiming to identify genetic factors associated with lysozyme resistance in methicillin-resistant Staphylococcus aureus strains. After completing her BSc, Catarina Guerreiro Simões pursued a Master's (MSc) in Molecular Genetics and Biomedicine at NOVA School of Science and Technology, where she deepened her understanding of molecular genetics, cellular and molecular biology, and microbiology with a focus on medical applications. In her master’s thesis titled “Carbon monoxide-mediated pro-regenerative and non-inflammatory microglial phagocytosis: towards clearance of dead neurons”, developed at the Molecular Mechanisms of Disease Lab, UCIBIO, she investigated the role of carbon monoxide in modulating microglial phagocytosis of dead neurons, focusing on cellular processes such as cargo recognition, engulfment, and lysosomal degradation. Furthermore, Catarina completed the Postgraduate Program on Research Practice Level 1 at ITQB, designed to enhance scientific skills, emphasizing critical thinking, creativity, and communication, while promoting independence in scientific research. Currently, Catarina Guerreiro Simões is a research fellow in the Lysosomes and Disease group at NOVA Medical School. Her research focuses on understanding the intricate link between lysosome dysfunction and cell senescence, two critical processes in atherosclerosis, the leading cause of cardiovascular diseases (CVD). She aims to unveil whether lysosome dysfunction is the cause or consequence of cell senescence, potentially leading to the identification of new druggable targets for the pathology. During her research fellowship, Catarina contributed as a co-author to one peer-reviewed article and co-authored six posters presented at national and international scientific conferences. Moreover, Catarina collaborated on a contract research project funded by a multinational pharmaceutical company, fostering knowledge transfer between academia and industry, thereby creating value in both sectors.
Identification

Personal identification

Full name
Catarina Guerreiro Simões
Date of birth
1999/05/17
Gender
Female

Citation names

  • Guerreiro Simões, Catarina

Author identifiers

Ciência ID
6217-3543-7145
ORCID iD
0000-0003-1146-1737

Email addresses

  • catarina.simoes@nms.unl.pt (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Molecular Biology
  • Medical and Health Sciences - Basic Medicine - Pathology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2023 - 2024/06/28
Concluded
Postgraduate Program on Research Practice Level 1 (Pós-Graduação)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
19
2024/01/09 - 2024/04/02
Concluded
CONSCIOUS II pilot teaching course (Outros)
Masarykova univerzita, Czech Republic

Universidade Nova de Lisboa, Portugal

Université Paris Cité, France

University College Cork, Ireland

Szegedi Tudományegyetem, Hungary

Pécsi Tudományegyetem, Hungary

European Clinical Research Infrastructure Network, France

Erasmus Plus, Belgium
2023/12/11 - 2023/12/13
Concluded
Introduction to Image Analysis Course (Outros)
Universidade de Lisboa Instituto de Medicina Molecular, Portugal

Fundação Champalimaud, Portugal

Instituto Gulbenkian de Ciência, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal

Universidade NOVA de Lisboa NOVA Medical School, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2020 - 2022/12/06
Concluded
Molecular Genetics and Biomedicine (Mestrado)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Carbon monoxide-mediated pro-regenerative and non-inflammatory microglial phagocytosis: towards clearance of dead neurons" (THESIS/DISSERTATION)
18
2017 - 2020/07/10
Concluded
Molecular and Cellular Biology (Licenciatura)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Screening of a transposon library in Staphylococcus aureus for the study of lysozyme resistance" (THESIS/DISSERTATION)
17
Affiliation

Science

Category
Host institution
Employer
2023/04/12 - Current Researcher (Research) Universidade NOVA de Lisboa NOVA Medical School, Portugal
Universidade NOVA de Lisboa NOVA Medical School, Portugal
2019/07/01 - 2019/07/31 Research Trainee (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Projects

Contract

Designation Funders
2023/04/12 - Current Lysosome Dysfunction and cellular Senescence in atherogenesis: is there a link?
2022.01305.PTDC
Research Fellow
Universidade NOVA de Lisboa NOVA Medical School, Portugal
Ongoing
Outputs

Publications

Conference poster
  1. Guerreiro Simões, Catarina; Lopes, Elizeth; Ferreira, Inês S.; Ribeiro, Quélia; Ramalho, José; Marques, André R. A.; Vieira, Otília V. Corresponding author: Vieira, Otília V. "Unravelling the Connection Between Lysosomal Dysfunction and Senescence in Atherogenesis". Paper presented in NMS PhD Retreat 2024 - Lisbon, 2024.
  2. Inês S. Ferreira; Ribeiro, Quélia; Elizeth Lopes; Guerreiro Simões, Catarina; Hall, Michael J; Ramalho, Jose; Marques, André R. A.; Otilia V. Vieira. "Exploring the Effects of Oxidized Lipids on Murine Macrophages: A Pathway to Atherosclerosis". Paper presented in International FOR2625 Symposium on LYSOSOMES & AUTOPHAGY, 2024.
  3. Inês S. Ferreira; Ribeiro, Quélia; Elizeth Lopes; Guerreiro Simões, Catarina; Hall, Michael J; Ramalho, Jose; Marques, André R. A.; Vieira, Otília V. "Unravelling Atherosclerosis: Exploring Lysosomal Dysfunction and Cell Death in Murine Macrophages Exposed to Oxidized Lipids". Paper presented in 2nd MIA-Portugal Ageing Spring School, 2024.
  4. Marques, André R. A.; Ferraz, Maria J.; Ferreira, Inês S.; Lopes, Elizeth; Guerreiro Simões, Catarina; Aerts, Johannes M. F. G.; Vieira, Otília V. "Atherosclerotic plaques accumulate glucosylated cholesterol in response to lysosomal glycosphingolipid and cholesterol storage". Paper presented in Glycolipid and Sphingolipid Biology Gordon Research Conference, 2024.
  5. Luís Fialho; Inês S. Ferreira; Guerreiro Simões, Catarina; Lopes, Elizeth; Marques, André R. A.; Ramalho, José; Vieira, Otília V. "Cellular and Lysosomal Dysfunction Induced In Vitro by Cholesteryl Hemiglutarate in RAW264.7 Cells". Paper presented in Programa de Integração de Alunos em Trabalhos de Investigação (PIATI), 2023.
  6. Lopes, Elizeth; Machado-Oliveira, Gisela; Guerreiro Simões, Catarina; Inês S. Ferreira; Ramos, Cristiano; Ramalho, José; Maria I. L. Soares; et al. "The pro-atherogenic lipid cholesteryl hemiazelate induces lysosome dysfunction in murine fibroblasts". Paper presented in 1st NMS Research Week, 2023.
  7. Inês S. Ferreira; Lopes, Elizeth; Guerreiro Simões, Catarina; Marques, André R. A.; Vieira, Otília V.. "The Impact of Oxidized Lipids in the Homeostasis of Murine Macrophages: Insights into Atherosclerosis". Paper presented in 1st NMS Research Week, 2023.
Journal article
  1. Lopes, Elizeth; Machado-Oliveira, Gisela; Guerreiro Simões, Catarina; Ferreira, Inês S.; Ramos, Cristiano; Ramalho, José; Soares, Maria I. L.; et al. "Cholesteryl Hemiazelate Present in Cardiovascular Disease Patients Causes Lysosome Dysfunction in Murine Fibroblasts". Cells 12 24 (2023): 2826. http://dx.doi.org/10.3390/cells12242826.
    10.3390/cells12242826
Thesis / Dissertation
  1. "Carbon monoxide-mediated pro-regenerative and non-inflammatory microglial phagocytosis: towards clearance of dead neurons". Master, Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, 2022. http://hdl.handle.net/10362/146371.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/05/05 Carbon monoxide-mediated pro-regenerative and non-inflammatory microglial phagocytosis: towards clearance of dead neurons I Meeting of the Disease Pathways and Biomarkers Group
(Porto, Portugal)
2022/02/10 Carbon monoxide-mediated pro-regenerative and non-inflammatory microglial phagocytosis: towards clearance of dead neurons Interim Conference of Annual Dissertations for the Masters of the Departments of Chemistry and Life Sciences 2022
(Portugal)

Event participation

Activity description
Type of event
Event name
Institution / Organization
2023/10/16 - 2023/10/20 Share of research findings in the medical and biomedical fields between researchers at different career stages, fostering scientific discussions and an atmosphere of collaboration and innovation.
Conference
1st NMS Research Week
Universidade NOVA de Lisboa NOVA Medical School, Portugal
2022/04/08 - 2022/04/09 Presentations of the research findings developed within the project scope by several partners and collaborators worldwide
Conference
Lysocil Final Conference
2018/03/23 - 2018/03/27 Collaborator
Meeting
XXI National Meeting of Biology Students

Mentoring / Tutoring

Topic Student name
2024/01 - 2024/02 Internship Mentor Tomás Oliveira
2022/02 - 2022/04 Undergraduate Research Project Mentor Maria Conceição
Distinctions

Award

2023 Best Poster Presentation
Universidade NOVA de Lisboa NOVA Medical School, Portugal