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Cong Tang. Completed the Doktor (PhD) in Clinical Medicine in 2019/12/10 by Xi'an Jiaotong University, Master in Clinical Medicine in 2017/06/30 by Xi'an Jiaotong University, Candidatus in Pharmacology and Chemical Biology in 2019/10/10 by Emory University and Bachelor in Clinical Medicine in 2016/06/30 by Xi'an Jiaotong University. Is postdoctoral researcher in Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes. Published 11 articles in journals. Has 2 patent(s) registered. Works in the area(s) of Medical and Health Sciences with emphasis on Basic Medicine with emphasis on Pharmacology and pharmacy, Medical and Health Sciences with emphasis on Clinical Medicine, Natural sciences with emphasis on Biological Sciences with emphasis on Biochemistry and Natural sciences with emphasis on Biological Sciences with emphasis on Cell Biology.
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Identification

Personal identification

Full name
Cong Tang

Citation names

  • Tang, Cong

Author identifiers

Ciência ID
6213-029E-F967
ORCID iD
0000-0003-1661-6793

Email addresses

  • cong.tang@medicina.ulisboa.pt (Professional)
  • tangc1025@gmail.com (Personal)

Telephones

Mobile phone
  • 911917380 (Personal)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
  • Medical and Health Sciences - Clinical Medicine
  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Molecular Biology

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Chinese (Mother tongue)
Portuguese Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2017/09/01 - 2019/12/10
Concluded
 Clinical Medicine (Doktor (PhD))
Xi'an Jiaotong University, China
2017/07/10 - 2019/10/10
Concluded
 Pharmacology and Chemical Biology (Candidatus)
Emory University, United States
2016/09/01 - 2017/06/30
Concluded
 Clinical Medicine (Master)
Xi'an Jiaotong University, China
2011/09/01 - 2016/06/30
Concluded
 Clinical Medicine (Bachelor)
Xi'an Jiaotong University, China
Affiliation

Science

Category
Host institution 		Employer
2017/07/10 - 2019/10/10 Visiting Researcher (Research) Emory University, United States
2013/07/13 - 2013/08/15 Visiting Researcher (Research) The University of British Columbia, Canada

Positions / Appointments

Category
Host institution 		Employer
2020/09/15 - Current postdoctoral researcher Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Others

Category
Host institution 		Employer
2016/09/01 - 2017/07/04 Intern doctor Xi'an Jiaotong University Medical College First Affiliated Hospital, China
Projects

Grant

Designation Funders
2022/01/17 - 2025/01/16 SmartBox: Engineering the first generation of ROS responsive ADCs
PTDC/QUI-OUT/3989/2021
Post-doc
Ongoing
2017/07/04 - 2019/10/20 MD&PhD exchange program
NA
PhD Student Fellow
Emory University, United States

Xi'an Jiaotong University, China
Concluded

Contract

Designation Funders
2021/05/01 - 2023/04/30 E3-hijacking molecular glues of RNA binding protein IGF2BP1 in ovarian cancer
GA101038053
Post-doc Fellow
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Ongoing
2020/09/15 - 2021/04/30 Site-selelctive protein-modification chemistries for antibody-drug conjugates (ADCs)
SIMICA-GA 852985
Post-doc
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Concluded
Outputs

Publications

Conference paper
  1. Tang, Cong. "THER-17. BRAF-V600E DEGRADATION AS A THERAPEUTIC STRATEGY IN BRAF-V600E MUTANT GLIOMAS.". 2019.
    https://doi.org/10.1093/neuonc/noz036.224
Journal article
  1. Buwei Huang; Mohamad Abedi; Green Ahn; Brian Coventry; Isaac Sappington; Cong Tang; Rong Wang; et al. "Designed endocytosis-inducing proteins degrade targets and amplify signals". Nature (2024): https://doi.org/10.1038/s41586-024-07948-2.
    10.1038/s41586-024-07948-2
  2. Cong Tang; Rui Traquete; Elizabeth Henderson; João Conde; Sara Picaud; Panagis Filippakopoulos; Gonçalo Bernardes. "Abstract 5779: Enhancing selectivity and overcoming tissue-specific toxicity in drug discovery: A novel BET inhibitor with targeted delivery for prostate cancer treatment". Cancer Research (2024): http://dx.doi.org/10.1158/1538-7445.am2024-5779.
    10.1158/1538-7445.am2024-5779
  3. Cong Tang; Patrícia Corredeira; Sandra Casimiro; Wesley Sukdao; Luís Costa; Emma Yates; Gonçalo Bernardes. "Abstract 1268: Immune activation characterization via amino acid concentration signatures for multi-cancer early detection and CDKi treatment response prediction". Cancer Research (2024): http://dx.doi.org/10.1158/1538-7445.am2024-1268.
    10.1158/1538-7445.am2024-1268
  4. Maria Rebelo; Cong Tang; Ana R Coelho; Carlos Labão-Almeida; Matthias M Schneider; Laurie Tatalick; Pedro Ruivo; et al. "De Novo Human Angiotensin-Converting Enzyme 2 Decoy NL-CVX1 Protects Mice From Severe Disease After Severe Acute Respiratory Syndrome Coronavirus 2 Infection". The Journal of Infectious Diseases (2023): http://dx.doi.org/10.1093/infdis/jiad135.
    10.1093/infdis/jiad135
  5. Sigitas Mikutis; Maria Rebelo; Eliza Yankova; Muxin Gu; Cong Tang; Ana R. Coelho; Mo Yang; et al. "Proximity-Induced Nucleic Acid Degrader (PINAD) Approach to Targeted RNA Degradation Using Small Molecules". ACS Central Science (2023): http://dx.doi.org/10.1021/acscentsci.3c00015.
    10.1021/acscentsci.3c00015
  6. Leeroy Baron; Justine Hadjerci; Leishemba Thoidingjam; Marina Plays; Romain Bucci; Nolwenn Morris; Sebastian Müller; et al. "PSL Chemical Biology Symposia Third Edition: A Branch of Science in its Explosive Phase". ChemBioChem (2023): http://dx.doi.org/10.1002/cbic.202300093.
    10.1002/cbic.202300093
  7. Cong Tang; Ana R. Coelho; Maria Rebelo; Hannah Kiely-Collins; Tânia Carvalho; Gonçalo J. L. Bernardes. "A Selective SARS-CoV-2 Host-Directed Antiviral Targeting Stress Response to Reactive Oxygen Species". ACS Central Science 9 1 (2023): 109-121. http://dx.doi.org/10.1021/acscentsci.2c01243.
    10.1021/acscentsci.2c01243
  8. Xiulei Mo; Qiankun Niu; Andrey A. Ivanov; Yiu Huen Tsang; Cong Tang; Changfa Shu; Qianjin Li; et al. "Systematic discovery of mutation-directed neo-protein-protein interactions in cancer". Cell (2022): https://doi.org/10.1016/j.cell.2022.04.014.
    10.1016/j.cell.2022.04.014
  9. Cong Tang; Qiankun Niu; Danielle Cicka; Yuhong Du; Xiulei Mo; Haian Fu. "A time-resolved fluorescence resonance energy transfer screening assay for discovery of protein-protein interaction modulators". STAR Protocols 2 3 (2021): 100804-100804. https://doi.org/10.1016/j.xpro.2021.100804.
    10.1016/j.xpro.2021.100804
  10. Cong Tang; Xiulei Mo; Qiankun Niu; Alafate Wahafu; Xuan Yang; Min Qui; Andrey A. Ivanov; Yuhong Du; Haian Fu. "Hypomorph Mutation-Directed Small-Molecule Protein-Protein Interaction Inducers to Restore Mutant SMAD4-Suppressed TGF-ß Signaling". Cell Chemical Biology (2020): https://doi.org/10.1016/j.chembiol.2020.11.010.
    10.1016/j.chembiol.2020.11.010
  11. Tang, Cong. "Transcriptional regulation of FoxM1 by HIF-1a mediates hypoxia-induced EMT in prostate cancer". Oncology Reports (2019): http://dx.doi.org/10.3892/or.2019.7248.
    10.3892/or.2019.7248
  12. Tang, Cong. "Classic and Novel Signaling Pathways Involved in Cancer: Targeting the NF-¿B and Syk Signaling Pathways". Current Stem Cell Research & Therapy (2019): http://dx.doi.org/10.2174/1574888x13666180723104340.
    10.2174/1574888x13666180723104340
  13. Tang, Cong. "HTiP: High-Throughput Immunomodulator Phenotypic Screening Platform to Reveal IAP Antagonists as Anti-cancer Immune Enhancers". Cell Chemical Biology (2019): http://dx.doi.org/10.1016/j.chembiol.2018.11.011.
    10.1016/j.chembiol.2018.11.011
  14. Tang, Cong. "Large tumor suppressor 2, LATS2, activates JNK in a kinase-independent mechanism through ASK1". Journal of Molecular Cell Biology (2018): http://dx.doi.org/10.1093/jmcb/mjy061.
    10.1093/jmcb/mjy061
  15. Tang, Cong. "The clinical significance of vasculogenic mimicry and expression of VE-cadherin in patients with clear cell renal cell carcinoma". ¿¿¿¿¿¿¿¿ 9 (2017): https://www.cnki.com.cn/Article/CJFDTotal-MNWK201709007.htm.
    10.3969/j.issn.1009-8291.2017.09.006
  16. Tang, Cong. "Surgical treatment of 137 cases of pheochromocytoma/paraganglioma: outcome analysis and clinical experience from a single institution". ¿¿¿¿¿¿¿¿ 8 (2017): https://www.cnki.com.cn/Article/CJFDTotal-MNWK201708010.htm.
    10.3969/j.issn.1009-8291.2017.08.008
  17. Tang, Cong. "Research progress on malignant evolution of angiogenic mimicry and renal cell carcinoma". ¿¿¿¿¿¿¿¿ 4 (2017): https://www.cnki.com.cn/Article/CJFDTotal-MNWK201704020.htm.
    10.3969/j.issn.1009-8291.2017.04.017
  18. Tang, Cong. "Application of PBL teaching method combined with literature retrieval in clinical practice teaching of urology". ¿¿ 2 (2017): https://www.cnki.com.cn/Article/CJFDTotal-XBYX201702047.htm.
    10.13555/j.cnki.c.m.e.2017.02.044
Preprint
  1. "Systematic discovery of mutation-directed neo-protein-protein interactions in cancer". 2021. http://dx.doi.org/10.1101/2021.10.03.462422.
    10.1101/2021.10.03.462422

Intellectual property

Patent
  1. 2021. "Small Molecule Inducer of SMAD4 Complex for Cancer Therapy". United States.
    Allowed
  2. Tang, Cong. 2020. "KRAS G12V Mutant Binds to JAK1, Inhibitors, Pharmaceutical Compositions, and Methods Related Thereto".
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/11/11 Discovery of hypomorph mutation-directed small molecule protein-protein interaction inducers/molecular glues ICBS2021
Emory University (Atlanta, United States)
2021/10/13 Potential of natural product-- Piperlongumine against SARS-CoV-2 ACORN
(algarve, Portugal)
2020/10/19 E3-hijacking molecular glues of RNA binding protein IGF2BP1 in ovarian cancer ACORN
(algarve, Portugal)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2021/09/29 - Current NL-CVX1, a Computationally Designed De Novo Protein, Can Block Infection by SARS-CoV-2 Viral Variants of Concern
Conference
 IDWeek 2021
2019/04/06 - 2019/04/09 Attended 2019 ASPET Annual Meeting at EB (Experimental Biology) at Orlando, Florida.
Conference
 2019 ASPET Annual Meeting

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2020/12/15 finding a small-molecule compound that corrects a defective protein-protein interaction Lab Land-The Emory Health Science Research Blog
2019/01/10 Uncovering more options in cancer immunotherapy Emory New's Center