???global.info.a_carregar???
Identification

Personal identification

Full name
Carla Marisa Pacheco Magalhães

Citation names

  • Magalhães, Carla M.

Author identifiers

Ciência ID
6117-3AE8-EFC5
ORCID iD
0000-0002-9152-7865

Email addresses

  • up201201533@up.pt (Professional)

Websites

Knowledge fields

  • Exact Sciences - Chemical Sciences
  • Medical and Health Sciences - Clinical Medicine - Oncology
  • Natural sciences - Biological Sciences - Biochemistry
  • Exact Sciences - Physical Sciences - Chemical Physics
  • Exact Sciences - Chemical Sciences - Organic Chemistry
  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
English Upper intermediate (B2) Advanced (C1) Advanced (C1) Advanced (C1) Intermediate (B1)
Education
Degree Classification
2020/10/01 - 2024
Ongoing
 PhD in Chemistry (Doctor)
Faculty of Sciences, University of Porto, Portugal
"Bioresponsive Nanomaterials for Combined Chemo/Photodynamic Therapy of Cancer and Biomedical Imaging" (THESIS/DISSERTATION)
2016 - 2018
Concluded
 Master in Oncology (Master)
Biomedical Sciences Institute Abel Salazar, University of Porto , Portugal
"A New Approach for Cancer Therapy Based on Marine Chemiluminescence" (THESIS/DISSERTATION)
 18
2012 - 2016
Concluded
 Biochemistry (Bachelor)
Faculty of Sciences, University of Porto, Portugal
"Development of novel cancer therapies based on marine chemiluminescence" (THESIS/DISSERTATION)
 14
Affiliation

Science

Category
Host institution 		Employer
2018/08/01 - 2019/09/01 Researcher (Research) Faculty of Sciences, University of Porto, Portugal
Faculty of Sciences, University of Porto, Portugal
2017/09 - 2018/01 Researcher (Research) Faculty of Sciences, University of Porto, Portugal
Projects

Grant

Designation Funders
2019/10/01 - Current Bioresponsive Nanomaterials for Combined Chemo/Photodynamic Therapy of Cancer and Biomedical Imaging
PTDC/QEQ-QFI/0289/2014
PhD Student Fellow
Universidade do Porto Faculdade de Ciências, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Ongoing

Contract

Designation Funders
2021/01/01 - 2023/12/31 Marine Chemiluminescence as a Broad-Spectrum Anticancer Therapy with Enhanced Tumor-Selectivity and Activity
PTDC/QUI-QFI/2870/2020
Universidade do Porto Faculdade de Ciências, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade do Porto Centro de Investigação em Química, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing

Other

Designation Funders
2022/06/03 - 2022/06/05 Characterization of the structural changes of bio-macromolecules upon cells interaction with tumor-selective and self-activating photosensitizers based on Coelenterazine: FTIR spectroscopical study
AV-2021075222
PhD Student Fellow
Cancelled
Outputs

Publications

Book
  1. Photodynamic Therapy. 2022.
    10.3390/books978-3-0365-5874-5
  2. Pinto Da Silva, L.; Magalhães, C.M.; Ferreira, P.J.O.; Crista, D.M.A.. Chemi-and bioluminescence in selfilluminating photodynamic therapy. Nova Science Publishers. 2017.
    Published
Book chapter
  1. Magalhães, Carla M.. "Tumor-Selective and Self-Activating Chemiluminescent Photosensitizers for Photodynamic Therapy". edited by Margetic, Davor; Thomas, Renjith. nova science publishers, 2022.
    10.52305/kwav1221
Conference paper
  1. Carla M. Magalhães; Patricia González-Berdullas; Joaquim C. G. Esteves da Silva; Luís Pinto da Silva. "Chemiluminescent Self-Activating Photosensitizers for Selective Anticancer Therapy". 2022.
    10.3390/ECMC2022-13174
Journal article
  1. Carla M. Magalhães; Renato B. Pereira; El Hadi Erbiai; Patricia González-Berdullas; Joaquim C.G. Esteves da Silva; David M. Pereira; Luís Pinto da Silva. "Comparative investigation into the anticancer activity of analogs of marine coelenterazine and coelenteramine". Bioorganic Chemistry (2024): http://dx.doi.org/10.1016/j.bioorg.2023.107083.
    10.1016/j.bioorg.2023.107083
  2. Carla M. Magalhães; Joaquim C. G. Esteves da Silva; Luís Pinto da Silva. "Investigation of the Chemiluminescent Reaction of a Fluorinated Analog of Marine Coelenterazine". Materials (2024): https://doi.org/10.3390/ma17040868.
    10.3390/ma17040868
  3. Magalhaes, Carla M.; Ducic, Tanja; Pereira, Renato B.; González-Berdullas, Patricia; Rodríguez-Borges, José E.; Pereira, David M.; Esteves da Silva, Joaquim C.G.; Algarra, Manuel; Pinto da Silva, Luís. "Synchrotron-based FTIR evaluation of biochemical changes in cancer and noncancer cells induced by brominated marine coelenteramine". Archives of Biochemistry and Biophysics 743 (2023): 109660. http://dx.doi.org/10.1016/j.abb.2023.109660.
    10.1016/j.abb.2023.109660
  4. Carla M. Magalhães; Patricia González-Berdullas; Mariana Pereira; Diana Duarte; Nuno Vale; Joaquim C. G. Esteves da Silva; Luís Pinto da Silva. "Investigation of the Anticancer and Drug Combination Potential of Brominated Coelenteramines toward Breast and Prostate Cancer". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms232213981.
    10.3390/ijms232213981
  5. João Sousa; Carla M. Magalhães; Patricia González-Berdullas; Joaquim C. G. Esteves da Silva; Luís Pinto da Silva. "Comparative Investigation of the Chemiluminescent Properties of a Dibrominated Coelenterazine Analog". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms23158490.
    10.3390/ijms23158490
  6. Patricia González-Berdullas; Renato B. Pereira; Cláudia Teixeira; José Pedro Silva; Carla M. Magalhães; José E. Rodríguez-Borges; David M. Pereira; Joaquim C. G. Esteves da Silva; Luís Pinto da Silva. "Discovery of the Anticancer Activity for Lung and Gastric Cancer of a Brominated Coelenteramine Analog". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms23158271.
    10.3390/ijms23158271
  7. Carla M. Magalhães; Joaquim C. G. Esteves da Silva; Luís Pinto da Silva. "Tuning the Intramolecular Chemiexcitation of Neutral Dioxetanones by Interaction with Ionic Species". Molecules (2022): https://doi.org/10.3390/molecules27123861.
    10.3390/molecules27123861
  8. Magalhães, Carla M.. "Theoretical Study of the Thermolysis Reaction and Chemiexcitation of Coelenterazine Dioxetanes". The Journal of Physical Chemistry A (2022): http://dx.doi.org/10.1021/acs.jpca.2c01835.
    10.1021/acs.jpca.2c01835
  9. Carla M. Magalhães; Patricia González-Berdullas; Diana Duarte; Ana Salomé Correia; José E. Rodríguez-Borges; Nuno Vale; Joaquim C. G. Esteves da Esteves da Silva; Luís Pinto da Pinto da Silva. "Target-Oriented Synthesis of Marine Coelenterazine Derivatives with Anticancer Activity by Applying the Heavy-Atom Effect". Biomedicines 9 9 (2021): 1199-1199. https://doi.org/10.3390/biomedicines9091199.
    10.3390/biomedicines9091199
  10. Magalhães, Carla M.. "Elucidating the Chemiexcitation of Dioxetanones by Replacing the Peroxide Bond with S-S, N-N and C-C Bonds". New Journal of Chemistry (2021): http://dx.doi.org/10.1039/d1nj03440e.
    10.1039/d1nj03440e
  11. Pinto da Silva, Luís; Núnez-Montenegro, Ara; Magalhães, Carla M.; Ferreira, Paulo J.O.; Duarte, Diana; González-Berdullas, Patricia; Rodríguez-Borges, José E.; Vale, Nuno; Esteves da Silva, Joaquim C.G.. "Single-molecule chemiluminescent photosensitizer for a self-activating and tumor-selective photodynamic therapy of cancer". European Journal of Medicinal Chemistry 183 (2019): 111683. http://dx.doi.org/10.1016/j.ejmech.2019.111683.
    Published • 10.1016/j.ejmech.2019.111683
  12. Min, Chun-Gang; Liu, Qing-Bo; Leng, Yan; Magalhães, Carla M.; Huang, Shao-Jun; Liu, Chun-Xia; Yang, Xi-Kun; da Silva, Luís Pinto. "Mechanistic Insight into the Chemiluminescent Decomposition of Cypridina Dioxetanone and the Chemiluminescent, Fluorescent Properties of the Light Emitter of Cypridina Bioluminescence". Journal of Chemical Information and Modeling 59 10 (2019): 4393-4401. http://dx.doi.org/10.1021/acs.jcim.9b00614.
    10.1021/acs.jcim.9b00614
  13. Pinto da Silva, Luís; Magalhães, Carla M.; Núñez-Montenegro, Ara; Ferreira, Paulo J.O.; Duarte, Diana; Rodríguez-Borges, José E.; Vale, Nuno; Esteves da Silva, Joaquim C.G.. "Study of the Combination of Self-Activating Photodynamic Therapy and Chemotherapy for Cancer Treatment". Biomolecules 9 8 (2019): 384. http://dx.doi.org/10.3390/biom9080384.
    10.3390/biom9080384
  14. Magalhães, Carla M.; Esteves da Silva, Joaquim C.G.; Pinto da Silva, Luís. "Comparative study of the chemiluminescence of coelenterazine, coelenterazine-e and Cypridina luciferin with an experimental and theoretical approach". Journal of Photochemistry and Photobiology B: Biology 190 (2019): 21-31. http://dx.doi.org/10.1016/j.jphotobiol.2018.11.006.
    10.1016/j.jphotobiol.2018.11.006
  15. Pinto da Silva, Luís; Magalhães, Carla M.. "Mechanistic insights into the efficient intramolecular chemiexcitation of dioxetanones from TD-DFT and multireference calculations". International Journal of Quantum Chemistry (2018): e25881. http://dx.doi.org/10.1002/qua.25881.
    Published • 10.1002/qua.25881
  16. Magalhães, Carla M.; Esteves da Silva, Joaquim C.G.; Pinto da Silva, Luís. "Study of coelenterazine luminescence: Electrostatic interactions as the controlling factor for efficient chemiexcitation". Journal of Luminescence 199 (2018): 339-347. http://dx.doi.org/10.1016/j.jlumin.2018.03.069.
    10.1016/j.jlumin.2018.03.069
  17. Pinto da Silva, Luís; Pereira, Rui F. J.; Magalhães, Carla M.; Esteves da Silva, Joaquim C. G.. "Mechanistic Insight into Cypridina Bioluminescence with a Combined Experimental and Theoretical Chemiluminescent Approach". The Journal of Physical Chemistry B 121 33 (2017): 7862-7871. http://dx.doi.org/10.1021/acs.jpcb.7b06295.
    Published • 10.1021/acs.jpcb.7b06295
  18. Pinto da Silva, L.; Magalhães, C. M.; Crista, D. M. A.; Esteves da Silva, J. C. G.; L. Pinto da Silva; C. M. Magalhães; D. M. A. Crista; J. C. G. Esteves da Silva. "Theoretical modulation of singlet/triplet chemiexcitation of chemiluminescent imidazopyrazinone dioxetanone via C8-substitution". Photochemical & Photobiological Sciences 16 6 (2017): 897-907. http://dx.doi.org/10.1039/c7pp00012j.
    10.1039/c7pp00012j
  19. Pinto da Silva, Luís; Magalhães, Carla M.; Esteves da Silva¿, Joaquim C. G.. "Interstate Crossing-Induced Chemiexcitation Mechanism as the Basis for Imidazopyrazinone Bioluminescence". ChemistrySelect 1 12 (2016): 3343-3356. http://dx.doi.org/10.1002/slct.201600688.
    10.1002/slct.201600688
  20. Magalhães, Carla. "Theoretical Optimization of the Electron Transfer Involving Chemiluminescent Coelenterazine". Science Letters Journal 1 (2016): 25231-25238.
    Published
  21. Magalhães, C.M.; Esteves da Silva, J.C.G.; Pinto da Silva, L.; Magalhães, Carla. "Chemiluminescence and Bioluminescence as an Excitation Source in the Photodynamic Therapy of Cancer: A Critical Review". ChemPhysChem (2016): 2286-2294. http://www.scopus.com/inward/record.url?eid=2-s2.0-84982908354&partnerID=MN8TOARS.
    10.1002/cphc.201600270
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/12/18 Development of novel anticancer molecules from metabolic products of the Coelenterazine bioluminescent system IMS/CIQUP-RG4 Meeting – Chemistry Unveiled – Pushing Boundaries in Research
CIQUP (Matosinhos, Portugal)
2023/11/23 Development of Chemiluminescent Coelenterazine Derivatives with Anticancer Potential XXVII Encontro Luso-Galego de Química
SPQ (Porto, Portugal)
2022/03/27 Chemiluminescence based self-activating photosensitizers for a selective anticancer therapy 5 International Turkish Congress on Molecular Spectroscopy
(Turkey)
2021/10 Self-illuminating chemiluminescent photosensitizers for a selective anticancer therapy Iberian Symposium of Young Photochemists 2021
2021/09/24 Quimiluminescência marinha como terapia anti-tumoral seletiva 3º Encontro Nacional de Jovens Investigadores em Oncologia
2021/03 Development and study of the combination of a new photosensitizer for a self-activating and tumor-selective photodynamic and chemotherapy for cancer treatment 14th Meeting of Physical Chemistry and 3rd Symposium of Computational Chemistry
The Portuguese Society of Chemistry (SPQ)
2020/02 Marine chemiluminescence as anti-tumor therapy with enhanced tumor-selectivity and activity III Workshop CIQUP meeting
CIQUP (Porto, Portugal)
2019/03/23 Synthesis and evaluation of self-excitable photosensitizers for Photodynamic Therapy of Cancer Frühjahrssymposium & EYCheM 2019
Universidade de Bremen (Bremen, Germany)
2019/02/13 Development of novel photosensitizers for Photodynamic Therapy of Cancer Encontro de Investigação Jovem da Universidade do Porto
Reitoria da Universidade do Porto (Porto, Portugal)
2018/11/21 Development of novel photosensitizers for Photodynamic Therapy of Cancer XXIV Encontro Luso-Galego de Química
Faculdade de Ciências da Universidade do Porto (Porto, Portugal)
2018/07/12 Development of Self-Excitable Photosensitizers for Photodynamic Therapy of Cancer VIII Meeting of the Paul Ehrlich Euro-PhD Network
Faculdade de Ciências da Universidade do Porto (Porto, Portugal)
2018/05/07 A New Approach for Cancer Therapy Based on Marine Chemiluminescence 2nd Symposium Of TheMSc In Oncology
Escola Portuguesa de Oncologia do Porto (Porto, Portugal)
2018/02 Study of the Chemiexcitation Step of Coelenterazine Luminescence Encontro de Investigação Jovem da Universidade do Porto
Faculdade de Medicina da Universidade do Porto (Porto, Portugal)
2017/02/08 Theoretical Characterization of the Chemiexcitation Mechanism of Chemi/Bioluminescent Imidazopyrazinone Encontro de Investigação Jovem da Universidade do Porto
Faculdade de Medicina da Universidade do Porto (Porto, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2019 - 2020 Mimicking Light-Emitting Biologic Systems for Catalytic Applications
Co-supervisor
 Environmental Sciences and Technology (Degree)
Faculty of Sciences, University of Porto, Portugal