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Completed the MSc in Biochemistry for health in 2018 and BSc in Biochemistry in 2016, both by Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia. Working in the area(s) of Natural sciences with emphasis on Biochemistry and Biochemical Research Methods. In 2019, I integrated the FCT project "Understand to treat: Combining in vitro and in silico strategies to explore new therapeutic approaches to the most common mitochondrial fatty acid ß-oxidation disorder (mFAO)" in the MetGenPro Lab (iMED.ULisboa), while collaborating on 3 other projects with different subjects. After authoring four scientific papers and ten poster communications and one oral communication for several events, I aim to improve human health and quality of life, while contributing to a better interconnection between the scientific community and the general public.
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Identification

Personal identification

Full name
Catarina Alexandra Catanas Madeira

Citation names

  • Madeira, Catarina A C
  • Madeira, C A
  • Madeira, C.

Author identifiers

Ciência ID
6113-7B49-3D34
ORCID iD
0000-0003-3973-6843
Researcher Id
AAF-4126-2021

Email addresses

  • catarinalexmad@gmail.com (Personal)

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Advanced (C1) Advanced (C1) Upper intermediate (B2)
Education
Degree Classification
2023/10/01 - 2027/10/01
Ongoing
 PhD in Pharmacy (Doutoramento)
Major in Biochemistry
Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/12/10 - 2023/02/11
Concluded
 Specialization in Clinical Research & Project Management (Outros)
Invictus Sciences, Portugal
 Approved
2022/02/10 - 2022/03/09
Concluded
 Fundamentals of Project Planning and Management (Coursera) Course (Outros)
University of Virginia Darden School of Business, United States
2016/03 - 2018/11/08
Concluded
 Bioquímica para a Saúde (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Activity of the major autolysin of Staphylococcus aureus Atl in the presence of extracellular DNA" (THESIS/DISSERTATION)
 17
2011/10 - 2016/02/16
Concluded
 Bioquímica (Licenciatura)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
 13
Affiliation

Science

Category
Host institution 		Employer
2019/02/08 - 2022/02/07 Researcher (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal

Others

Category
Host institution 		Employer
2017/07/03 - 2018/09/24 Internship (MSc final project) at Molecular Microbiology of Bacterial Pathogens Lab REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017/02/01 - 2017/05/30 Internship at the Neurogenetics of Locomotion Lab Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2015/09/21 - 2015/12/18 Internship (BSc final project) at Materials for Adsorption and Catalysis Lab Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
Outputs

Publications

Conference poster
  1. Madeira, Catarina; Bonito, Cátia; Ventura, Fátima V.; Ferreira Ricardo; Leandro, Paula. "Targeting the stability and activity of medium-chain acyl-CoA dehydrogenase p.K329E variant with penta- and hexapeptides". Paper presented in 19th SPDM Symposium, 2023.
  2. Madeira, C.; Bonito, C.A.; Santos, D.J.; Ventura, F. V.; Ferreira, R.J. ; Leandro, P.. "Targeting unstable regions of the most common variant medium-chain acyl-CoA dehydrogenase to develop strong candidates for pharmacological therapies". Paper presented in IUBMB–FEBS–PABMB Congress, 2022.
  3. Madeira, Catarina A C; Anselmo, C.; Ventura, F. V.; Leandro, P.. "Disease causing medium chain acyl CoA dehydrogenase variants: impact on FAD binding". Paper presented in 17h International Symposium SPDM, 2021.
  4. Madeira, Catarina A C; Bonito, C.A.; dos Santos, D.J.V.A.; Ventura, F.V. ; Ferreira, R.J. ; Leandro, P.. "Prospects for pharmacological intervention on mitochondrial Medium-chain acyl-CoA dehydrogenase deficiency: Targeting unstable regions". Paper presented in iMed.Ulisboa Meeting 2021, 2021.
  5. Bonito, C.A.; Madeira, Catarina A C; dos Santos, D.J.V.A.; Leandro, P.; Ventura, F. V.; Ferreira, R. J.. "Targeting the most common mutation in medium-chain acyl-CoA dehydrogenase with pharmacological chaperones: a breakthrough". Paper presented in 14° Encontro de Química Física, 2021.
  6. Madeira, Catarina A C; Anselmo, C.; Ventura, Fátima V.; Leandro, P.. "Insights into the structure of various medium-chain acyl-CoA dehydrogenase variants". Paper presented in 16th International Symposium of the Portuguese Society for Metabolic Disorders (SPDM), 2020.
  7. Anselmo, C.; Madeira, Catarina A C; Ventura, Fátima V.; Leandro, P.. "Functional evaluation of various human medium chain acyl-CoA dehydrogenase (hMCAD) variants using the natural electron acceptor: insights into the interaction with the electron transferring protein (ETF)". Paper presented in 16th International Symposium of the Portuguese Society for Metabolic Disorders (SPDM), 2020.
  8. Lopes, R.R; Russo, R.; Madeira, Catarina A C; Tomé, C.; Teixeira, M.; Vicente, J.B.; Guedes, C.R.; Góis, P.M.P.; Leandro, P.. "Protection of Human Phenylalanine Hydroxylase Activity by Small Molecules Targeting the Enzyme Catalytic Center". Paper presented in 11th iMed.ULisboa Postgraduate Students Meeting & 4th i3DU Meeting, 2019.
  9. Manuel, A.M.; Gonçalves, J.M.; Vítor, J.; Madeira, Catarina A C; Leandro, A.P.. "Proimmunotoxin: A Novel Design Strategy of Immunotoxins Applied to Breast Cancer". Paper presented in 11th iMed.ULisboa Postgraduate Students Meeting & 4th i3DU Meeting, 2019.
  10. Grilo, Inês R.; Madeira, Catarina A C; Loduvice, Ana Madalena; Sobral, Rita G.. "Exploring the interaction of the S. aureus glucosaminidase domain of Atl with DNA". Paper presented in 28th ECCMID - European Congress of Clinical Microbiology and Infectious Diseases, 2018.
Journal article
  1. Madeira, Catarina A.; Anselmo, Carolina; Costa, João M.; Bonito, Cátia A.; Ferreira, Ricardo J.; Santos, Daniel J.V.A.; Wanders, Ronald; et al. "Functional and structural impact of 10 ACADM missense mutations on human medium chain acyl-Coa dehydrogenase". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (2023): 166766. http://dx.doi.org/10.1016/j.bbadis.2023.166766.
    10.1016/j.bbadis.2023.166766
  2. Valentina Barcherini; Joana B. Loureiro; Ana Sena; Catarina Madeira; Paula Leandro; Lucília Saraiva; Alexandra M. M. Antunes; Maria M. M. Santos. "Metabolism-Guided Optimization of Tryptophanol-Derived Isoindolinone p53 Activators". Pharmaceuticals (2023): https://doi.org/10.3390/ph16020146.
    10.3390/ph16020146
  3. Santos, Raquel dos; Iria, Inês; Manuel, Ana M.; Leandro, Ana P.; Madeira, Catarina A. C.; Goncalves, Joao; Carvalho, Ana Luísa; Roque, Ana Cecília A.. "Magnetic Precipitation: A New Platform for Protein Purification". Biotechnology Journal 15 9 (2020): 2000151. http://dx.doi.org/10.1002/biot.202000151.
    10.1002/biot.202000151
  4. Maria Manuel Serrano Bernardo; Catarina Alexandra Catanas Madeira; Nuno Carlos Lapa dos Santos Nunes; Diogo André Costa Messias Dias; Delfina Maria Barbosa Godinho; Maria Filomena de Jesus Pinto; Inês Alexandra Morgado do Nascimento Matos; Ana Paula Batista Carvalho; Isabel Maria de Figueiredo Ligeiro Fonseca. "Study of the removal mechanism of aquatic emergent pollutants by new bio-based chars". Environmental Science and Pollution Research 24 28 (2017): 22698-22708. https://doi.org/10.1007%2Fs11356-017-9938-9.
    10.1007/s11356-017-9938-9
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/05/05 Impaired FAD incorporation: an additional factor contributing to the pathogenesis of medium-chain acyl CoA dehydrogenase deficiency 18th International Symposium of the SPDM
Portuguese Society for Metabolic Disorders (Peniche, Portugal)
2018/02/01 Regulation of the activity of the major autolysin of S. aureus Atl through extracelular DNA Jornadas Intercalares das Dissertações Anuais dos Mestrados dos Departamentos de Química e Ciências da Vida
Universidade Nova de Lisboa - Faculdade de Ciências e Tecnologia (Caparica, Portugal)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/03/29 - 2023/03/31 19th SPDM Symposium
Symposium
 19th SPDM Symposium
Sociedade Portuguesa de Doenças Metabólicas, Portugal
2022/07/09 - 2022/07/14 The Biochemistry Global Summit
Congress
 IUBMB–FEBS–PABMB Congress
International Union of Biochemistry and Molecular Biology, Canada

Federation of European Biochemical Societies, United Kingdom

Sociedade Portuguesa de Bioquímica, Portugal
2022/05/05 - 2022/05/07 "Unlimited Boundaries in Inborn Errors of Metabolism"
Symposium
 18th Internacional Symposium of SPDM
Sociedade Portuguesa de Doenças Metabólicas, Portugal
2021/09/08 - 2021/09/10 "Linking metabolic signature to IEM treatment", 17th Internacional Symposium of SPDM
Symposium
 "Linking metabolic signature to IEM treatment"
2021/06/16 - 2021/07/09 iMed.Ulisboa Meeting 2021
Meeting
 iMed.Ulisboa Meeting 2021
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2020/11/11 - 2020/11/13 "New horizons on Inborn Errors of Metabolism", 16th International Symposium of SPDM
Seminar
 16th International Symposium SPDM
2019/03/14 - 2019/03/16 "Old disease, new treatments", 15th International Symposium SPDM
Symposium
 15th International Symposium SPDM
2017/10/02 - 2017/10/02 3º Workshop de Genética
Workshop
 3º Workshop de Genética - NOVA Saúde
Universidade Nova de Lisboa, Portugal
2015/10/09 - 2015/10/09 1º Workshop de Genética
Workshop
 1º Workshop de Genética - NOVA Saúde
Universidade Nova de Lisboa, Portugal
2012 - 2015 JORTEC - Jornadas Tecnológicas (Edições 2012 a 2015)
Conference
 JORTEC - Jornadas Tecnológicas
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014/04/11 - 2014/04/14 VII ENEBIOQ - Biochemistry Students National Meeting
Meeting
 VII ENEBIOQ - Biochemistry Students National Meeting
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Mentoring / Tutoring

Topic Student name
2021/03 - 2021/09 Laboratory Instructor of MSc Erasmus student Arianna Cagnoni
2019/09 - 2020/12 Laboratory Instructor of MSc student Carolina Anselmo
2018/07/01 - 2018/07/31 Laboratory Instructor of Internship of Undergraduate Student Rafael Marques
2018/07/01 - 2018/07/31 Laboratory Instructor of Internship of Undergraduate Student Cláudia Fernandes
Distinctions

Award

2023 Honorable Mention for E-Poster "Targeting the stability and activity of medium chain acyl-CoA dehydrogenase p.K329E variant with penta- and hexapeptides"
Sociedade Portuguesa de Doenças Metabólicas, Portugal