Maria Teresa Cruz (6111-F90A-3CE1)

Curriculum Vitae

Maria Teresa Cruz

Maria Teresa Cruz (MT Cruz) holds a degree in Pharmaceutical Sciences (1991) from the University of Lisbon, a Master's in Drug Technologies (1996), and a PhD in Pharmacology (2004) from the University of Coimbra. MT Cruz is an Associate Professor with Habilitation at the Faculty of Pharmacy, University of Coimbra, and leads the Immunometabolism and Stress Response group at the Centre for Innovative Biomedicine and Biotechnology (CIBB), which investigates the interplay between cellular metabolism and immune response in inflammation and neurodegenerative diseases, aiming to identify therapeutic targets to modulate immune responses and promote cellular homeostasis. She is a European Registered Toxicologist (2018) and a European Certified Pharmacologist (2024). She has participated in 57 funded projects, leading 23, including those from the EU 7th Framework Programme, Johns Hopkins, Cosmetics Europe, Lierac, Society of Toxicology/Colgate-Palmolive, and Vichy. Co-author of 7 international patents and 8 provisional applications, she has published 248 papers in indexed journals, has an h-index of 45 with approximately 9700 citations (Web of Science) and is listed among the World’s Top 2% Scientists most cited in the world (2022, 2023, 2024). MT Cruz regularly reviews R&D projects for several institutions, including ERA4Health, the Netherlands Organisation for Scientific Research, the Flanders Research Foundation, the French National Research Agency, and the Alzheimer’s Association Research Fellowship Program. She has supervised or co-supervised 25 PhD students, 34 MSc students, and 3 postdoctoral fellows. In terms of knowledge transfer and valorization, MT Cruz has played a pivotal role in creating a spin-off from the UC, Toxfinder, which has received several entrepreneurship awards and has been actively involved in patents and providing specialized services to national and international entities. Furthermore, MT Cruz contributed to the design and establishment of a Pilot Production Unit for Cell Therapy, the UpCells laboratory, resulting from a partnership between UC and the pharmaceutical industry Tecnimede, meeting all the requirements for the preparation and handling of cellular products for clinical application according to GMP. During the SARS-CoV-2 pandemic, MT Cruz played a pivotal role as part of the coordination team at the University of Coimbra, overseeing diagnostic testing for Covid-19. She adapted laboratory facilities, conducted diagnostic tests, and trained nine teams of volunteers, totaling approximately 80 individuals. In terms of pedagogical activity, MT Cruz teaches various curricular units at the Faculty of Pharmacy, covering subjects such as Pharmacology, Histology and Human Embryology, Cell Biology, Molecular Biology, Immunology, Pathophysiology, Anatomy and Human Physiology, Pre-Clinical Drug Development, and Pharmacological Screening. She has also contributed to several master's and doctoral programs at the University of Coimbra and other institutions.

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Identification

Personal identification

Full name: Maria Teresa Cruz

Citation names

Cruz, Maria Teresa
Cruz MT
Cruz T

Author identifiers

Ciência ID: 6111-F90A-3CE1
ORCID iD: 0000-0001-9846-6754
Google Scholar ID: http://scholar.google.com/citations?user=sFivkSoAAAAJ
Researcher Id: F-5288-2013
Scopus Author Id: 7201363895

Knowledge fields

Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
English	Beginner (A1)	Advanced (C1)	Intermediate (B1)	Beginner (A1)

Education

	Degree	Classification
2024/07/11 - 2024/07/11 Concluded	Ciências Farmacêuticas, na especialidade de Farmacologia e Farmacoterapia (Habilitation (Aggregation Title)) Universidade de Coimbra, Portugal
2004/06/17 Concluded	Doutoramento em Ciências Farmacêuticas (Doctorate) Universidade de Coimbra Faculdade de Farmácia, Portugal	Aprovado por unanimidade com distinção e louvor
2004 Concluded	Farmácia (Doctorate) Major in Especialidade: Farmacologia Universidade de Coimbra Faculdade de Farmácia, Portugal "Vias de Sinalização Intracelular Envolvidas na Expressão da Isoforma Indutível da Sintase do No: Efeito do Lipopolissacarídeo, Citocinas e Alergénios em Células Dentríticas da Pele" (THESIS/DISSERTATION)
1996 Concluded	Mestrado em Tecnologias do Medicamento (Master's Degree) Universidade de Coimbra Faculdade de Farmácia, Portugal	Muito Bom
1992 Concluded	Ciências Farmacêuticas (Licenciate Degree) Universidade de Lisboa Faculdade de Farmácia, Portugal	17 valores

Affiliation

Science

	Category Host institution	Employer
1996/10/07 - Current	Researcher (Research)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2022/04/01 - Current	Associate Professor (University Teacher)	Universidade de Coimbra, Portugal
	Universidade de Coimbra, Portugal
2020 - Current	Associate Professor (University Teacher)	Universidade de Coimbra, Portugal

2004/06/18 - Current	Assistant Professor (University Teacher)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
	Hospitais da Universidade de Coimbra, Portugal
1996/10/08 - 2004/06/17	Assistant (University Teacher)	Universidade de Coimbra, Portugal
	Universidade de Coimbra, Portugal

Other Careers

	Category Host institution	Employer
1993/04/26 - 1993/10/11	Senior Technician (Senior Technician)	Hospital Infante Dom Pedro-Aveiro, Portugal
	Hospital Infante Dom Pedro-Aveiro, Portugal
1992/04/01 - 1992/04/26	Senior Technician (Senior Technician)	Hospital Curry Cabral, Portugal

Others

	Category Host institution	Employer
2011/09/01 - Current	Sócio fundador da Spin off da Universidade de Coimbra	Toxfinder Lda, Portugal
	Toxfinder Lda, Portugal

Projects

Grant

	Designation	Funders
2019 - Current	Circadian rhythm disruption in Bipolar disorder: from molecular mechanisms to novel therapeutic targets SFRH/BD/148653/2019 SFRH/BD/148653/2019 Supervisor Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Associação para a Inovação e Desenvolvimento da FCT
2016 - Current	Estágio de investigação no Departamento de Microbiologia e Imunologia, na UNESP, Campus de Botucatu, Brasil, ESTÁGIO INVESTIGAÇÃO Invited Scientist Fellow Fundação para o Desenvolvimento da UNESP, Brazil
2013 - Current	estágio de investigação no Departamento de Microbiologia e Imunologia, na UNESP, Campus de Botucatu, Brasil estágio de investigação no Departamento de Microbiologia e Imunologia, na UNESP Invited Scientist Fellow Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil	Concluded
2011/01/01 - Current	IN VITRO CELLULAR APPROACH FOR SKIN SENSITIZATION HAZARD: AN EU LEGISLATION DEMAND SFRH/BD/73065/2010 Supervisor Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2025/04/01 - 2026/03/31	Targeting Key Event 4: A New Approach Methodology for Skin and Respiratory Sensitizers Detection with Human PBMCs 0000000035
2018/06/30 - 2022/05/31	Characterization of phytochemical components of Eucalyptus globulus leaves and their pharmacological potentials: a multi-functional insight. InPaCTus” COMPETE2020 nº 21874 Supervisor Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Ongoing
2018/06/30 - 2022/05/31	Development of a Medical Device for prevention of Allergic Contact Dermatitis PD/BDE/142926/2018 PD/BDE/142926/2018 Supervisor Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT Ongoing
2021/01/22 - 2021/11/16	TECNICOV: Development of rapid testes for antibody anti-SARS-CoV-2 monitorization in serum and saliva. POCI-01-02B7-FEDER-069745	Fundação para a Ciência e a Tecnologia Concluded
2017/03/01 - 2021/02/28	Desenvolvimento de plataformas baseadas em células dendriticas para screening toxicológico e farmacológico PD/BDE/135076/2017 Supervisor Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2016/04/01 - 2020/03/30	“Desenvolvimento de uma plataforma in-vitro/in chemico para a identificação de alergénios respiratórios SFRH/BD/110717/2015 Supervisor Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2019/01 - 2019/12	CNC. IBILI 154730UID UID/NEU/04539/2019 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal Universidade de Coimbra, Portugal Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2012/01/01 - 2016/12/31	ELECTROPHILIC STRESS: MOLECULAR TARGETS FOR SKIN SENSITIZERS SFRH/BPD/90378/2012 Supervisor Universidade de Aveiro, Portugal	Concluded
2014/06/01 - 2015/12/31	ToxVitroTesting”. Quadro de Referência Estratégico Nacional (QREN) – Empresas em co-promoção project ref: 38977, 2014 Supervisor Toxfinder Lda, Portugal	Concluded
2011/01/01 - 2014/12/31	FRAGARIA VESCA LEAF AS A SOURCE OF BIOACTIVE PHYTOCHEMICALS - A FOCUS ON ELLAGITANNINS AND THEIR HUMAN MICROFLORA METABOLITES SFRH/BD/72918/2010 Supervisor Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2009/10/01 - 2012/12/31	Cellular and Molecular Mechanisms of Impaired Wound Healing in Diabetes: Understanding the Role of Substance P and Mast Cells SFRH/BD/48624/2008 Supervisor Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2009/01/01 - 2012/12/31	Anti-inflammatory mechanism and properties of plants used in traditional medicine: evaluation of their potential use as source for new anti-inflammatory drugs SFRH/BD/46281/2008 Supervisor Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2007/01/01 - 2010/12/31	Identification of cellular and molecular markers selectively activated by skin sensitizers in dendritic cells SFRH/BD/30563/2006 Supervisor Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
1996/01/01 - 1996/05/31	Vias de sinalização intracelular envolvidas na expressão da isoforma indutível da sintase do NO: efeito do lipopolissacarídeo, citocinas e alergénios em células dendríticas da pele BD/5176/95 PhD Student Fellow Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
1993/10/01 - 1995/09/30	Mestrado em Tecnologias do Medicamento BM/2363/93 Master Student Fellow Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Contract

	Designation	Funders
2020 - Current	Impacto da ação de produtos naturais sobre células envolvidas na imunidade e em células tumorais humanas CAPES-PRINT-UNESP – EDITAL 02/2019 CONVÊNIO CAPES-PRINT-UNESP – EDITAL 02/2019, REDES DE PESQUISA INTERNACIONAIS CONVÊNIO CAPES-PRINT-UNESP EDITAL 02/2019, REDES DE PESQUISA INTERNACIONAIS CAPES-PRINT-UNESP EDITAL 02/2019 Invited Scientist Fellow Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil	N/A Ongoing
2018/07/22 - Current	PulManCar: Microparticles design for active compounds pulmonary delivery using insulin as model POCI-01-0145-FEDER-029560 Researcher Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Associação para a Inovação e Desenvolvimento da FCT
2017/09/01 - Current	ImmunoDCs@CancerStemCells: Imunoterapia celular direcionada para a eliminação de células estaminais cancerígenas 033532 Researcher Universidade de Coimbra, Portugal	Ongoing
2017 - Current	IBERPHENOL: Red cooperativa de investigación en el ámbito de polifenoles y sus aplicaciones industriales , project EP - INTERREG V A España Portugal (POCTEP) , project EP - INTERREG V A España Portugal (POCTEP) Researcher Universidade de Coimbra Faculdade de Farmácia, Portugal	N/A Ongoing
2017 - Current	HealthyAging2020 CENTRO-01-0145-FEDER-000012-2017-2020 Researcher Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Concluded
2017 - Current	InPaCTus”, Centro de Excelência, PORTUGAL2020, projeto co-promoção "The Navigator Company"-RAIZ-Univ. Coimbra-Univ. Aveiro (sub-projeto “Extractos de valor acrescentado de biomassa floresta portugal 2020 Researcher Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Ongoing
2026/01/01 - 2028/02/29	Vitage - Valorização de resíduos agrícolas em produtos anti-envelhecimento PD25-00049 Universidade de Coimbra, Portugal Universidad de Salamanca, Spain Instituto Politécnico de Castelo Branco Escola Superior Agrária, Portugal Centro de Biotecnologia de Plantas da Beira Interior, Portugal	Ongoing
2021/01/01 - 2025/12/31	Centro de Inovação em Biomedicina e Biotecnologia - Laboratório Associado LA/P/0058/2020 10.54499/LA/P/0058/2020 Universidade de Coimbra, Portugal Universidade Nova de Lisboa ¿Laboratório de Instrumentação Engenharia Biomédica e Física da Radiação, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2022/09/01 - 2025/08/31	PLANTS4AGEING - Potencial of Medicinal Plants in Cardiovascular Ageing na Universidade de Coimbra, Portugal Universidad de Salamanca, Spain Instituto Politécnico de Castelo Branco Escola Superior Agrária, Portugal Centro de Biotecnologia de Plantas da Beira Interior, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2020/01/01 - 2024/12/31	Centro de Inovação em Biomedicina e Biotecnologia UIDP/04539/2020 10.54499/UIDP/04539/2020 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2023/03/12 - 2024/09/11	Epigenetic modulation of blood-brain barrier integrity for the prevention of epileptogenesis 2022.03133.PTDC 10.54499/2022.03133.PTDC Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2022/09/01 - 2024/03/31	Center for Innovative Biomedicine and Biotechnology - Associate Laboratory LA/P/0058/2020 Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2019/10 - 2022/10	"Impact of the action of natural products on human innate immune and tumor cells." # 88887.194785/2018-00 Researcher Universidade Estadual Paulista Júlio de Mesquita Filho Câmpus de Botucatu Instituto de Biociências, Brazil	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Ongoing
2018/06/22 - 2022/04/21	Development of a Novel Nose-to-Brain multifunctional nanoplatform for the treatment of Depression and prevention of pharmacoresistance development PTDC/SAU-SER/30752/2017 CENTRO-01-0145-FEDER-030752 Researcher Universidade de Coimbra, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Associação para a Inovação e Desenvolvimento da FCT Ongoing
2018/09 - 2021/09/16	Vesículas extracelulares de Giardia lamblia na imunomodulação de células do hospedeiro: potencial aplicação terapêutica das EVs de Giardia na inflamação intestinal PTDC/SAU-PAR/31506/2017 PTDC/SAU-PAR/31506/2017 Researcher Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Associação para a Inovação e Desenvolvimento da FCT Fundação para a Ciência e a Tecnologia Ongoing
2018/07/27 - 2021/07/25	The ups and downs of cellular stress: the “MAM hypothesis” for Bipolar disorder pathophysiology CENTRO-01-0145-FEDER-028214 PTDC/MED-NEU/28214/2017 Researcher Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Associação para a Inovação e Desenvolvimento da FCT Fundação para a Ciência e a Tecnologia Ongoing
2018/07/26 - 2021/07/25	Skin allergens: molecules with an improbable therapeutic application for Alzheimer's disease PTDC/MED-FAR/29369/2017 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/07/15 - 2021/07/14	Hepatitis B therapeutic vaccine: Production of glucan-based nanoparticles towards selective delivery hepatitis B antigens to immune cells to induce antiviral activity. PTDC/MEC-GAS/30331/2017 POCI-01-0145-FEDER-030331 POCI-01-0145-FEDER-030331 Researcher Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Associação para a Inovação e Desenvolvimento da FCT Ongoing
2018/07/28 - 2021/06/30	Allergens4AD-Skin allergens: molecules with an improbable therapeutic application for Alzheimer's disease POCI-01-0145-FEDER-029369 Principal investigator Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/07/01 - 2021/06/30	Microparticles design for active compounds pulmonary delivery using insulin as model PTDC/EQU-EPQ/29560/2017 Universidade de Aveiro, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2016/02/02 - 2021	Optimization of a defined approach for skin sensitizer potency integrating in silico, in chemico and in vitro cell data for classifying chemicals accordingly to five categories (extreme, strong, moderate, weak and non-sensitizer). Cosmetics Europe Principal investigator Cosmetics Europe, Belgium	Ongoing
2017 - 2018	Valorization of the Thermal resorts of the Centre Region - Characterization of the bioactive potential of the thermal water resources of the Region - "Study of the therapeutic properties of thermal waters - dermocosmetic" CENTRO-04-3928-FEDER-000010 CENTRO-04-3928-FEDER-000010 Principal investigator Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	N/A Concluded
2015 - 2017	Própolis: “Modulation of antigenic presentation and differential activation of T lymphocytes”. 2015/03493-3 Researcher	Fundação de Amparo à Pesquisa do Estado de São Paulo Concluded
2014 - 2015	Development and validation of a pilot laboratory for cell therapy (UpCells) 5378/2014 5378/2014 Researcher	N/A Concluded
2014 - 2015	Exosomes: putative biomarkers for respiratory and cutaneous allergens hazard PRIME-XS project, grant agreement number 262067 Principal investigator Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Concluded
2014 - 2015	ToxVitroTesting 38977 Principal investigator Toxfinder Lda, Portugal	Concluded
2014 - 2015	Generation of a novel dendritic cell-based vaccine against glioblastoma INOVC Principal investigator	Concluded
2013 - 2015	In chemico, in silico and in vitro dendritic cell modeling to predict human respiratory allergens John Hopkins 2013 Principal investigator Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Concluded
2010/05/01 - 2013/10/31	Anti-inflammatory mechanism and properties of medicinal plants: a multidisciplinary research for their validation and utilization as a source of phytopharmaceuticals PTDC/SAU-FCF/105429/2008 info:eu-repo/grantAgreement/FCT/5876-PPCDTI/105429/PT Researcher Universidade de Coimbra, Portugal Universidade de Coimbra Centro de Estudos Farmacêuticos, Portugal Universidade de Aveiro, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Associação para a Inovação e Desenvolvimento da FCT Concluded
2010/04/01 - 2013/09/30	Implication of sirtuin proteins in the regulation of antigen presenting cells apoptosis during leishmaniasis: a therapeutic approach PTDC/SAU-FCF/100749/2008 Researcher Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Associação para a Inovação e Desenvolvimento da FCT Concluded
2010/04/01 - 2013/09/30	In vitro alternative approach for chemical skin sensitization hazard: an EU legislation demand PTDC/SAU-OSM/099762/2008 info:eu-repo/grantAgreement/FCT/5876-PPCDTI/99762/PT Principal investigator Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Universidade de Aveiro, Portugal	Fundação para a Ciência e a Tecnologia Associação para a Inovação e Desenvolvimento da FCT Concluded
2010/04/01 - 2013/09/30	Role and mechanism of action of immunoregulatory iNKT and DC cells in Leishmania infection: new approaches for vaccination? PTDC/SAU-FCF/101017/2008 info:eu-repo/grantAgreement/FCT/5876-PPCDTI/101017/PT Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Associação para a Inovação e Desenvolvimento da FCT Concluded
2011 - 2013	Phenolic compounds of cork: cosmetic validation, alimentary evaluation and nutraceutic potential – NutraCork 21597/2011 Researcher	Concluded
2009/01/05 - 2012/10/04	Whole human genome analysis of genetic imbalances and numerical abnormalities by single-nucleotide polymorphism (SNP)-arrays in gliomas: correlation with clinical and biological features of the disease. PIC/IC/83108/2007 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Hospitais da Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2011 - 2012	Projecto Estratégico - UI 158 PEst-OE/COM/UI0158/2011 Universidade Nova de Lisboa Instituto de Comunicação da Nova, Portugal	Concluded
2009 - 2011	Extraction and isolation of compounds with high biological potential from by-products of the cork industry – BioactiveCork 5455/2009 Researcher	Concluded
2008 - 2010	Dissecting the molecular mechanisms of wound healing in diabetes - the role of neuropeptides PTDC/SAU-MII/098567/2008 Researcher Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Associação para a Inovação e Desenvolvimento da FCT Concluded
2007/08/16 - 2009/12/31	ROLE OF DENDRITIC CELLS IN LEISHMANIASIS: intracellular signalling pathways activated by virulent and attenuated parasite Leismania infantum PTDC/SAU-FCF/67351/2006 PTDC/SAU-FCF/67351/2006 Researcher Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Associação para a Inovação e Desenvolvimento da FCT Concluded
2008 - 2009	Cellular and molecular mechanisms of dendritic cells activation by skin sensitizers and irritants Lierac, grupo Alés, Paris Principal investigator Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Concluded
2007 - 2008	Identificação de marcadores celulares activados selectivamente por alergénios de contacto em células dendríticas 17/07 Principal investigator Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Universidade de Coimbra Faculdade de Medicina Concluded
2006 - 2008	Intracellular Signaling pathways involved on the expression of proteins related to the glioblastoma cells progression CIMAGO, 10/06 Researcher Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia Concluded
2006 - 2007	Activação de vias de sinalização intracelular em células dendríticas: acção de fármacos imunossupressores 12/06 Principal investigator Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Universidade de Coimbra Faculdade de Medicina Concluded
2001/01/15 - 2003	Early Cellular Events Induced by Different Sensitizing Chemicals in Skin Derived Dendritic Antigen Presenting Cells info:eu-repo/grantAgreement/FCT/POCI/36373/PT Researcher Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Associação para a Inovação e Desenvolvimento da FCT Concluded
1996 - 1998	Intracellular signaling pathways activated by cytokines and allergens in antigen presenting cells PRAXIS/PSAU/P/SAU/126/96 PRAXIS/PSAU/P/SAU/126/96 Researcher Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Associação para a Inovação e Desenvolvimento da FCT Concluded
1995 - 1997	Mecanismos de morte celular durante a terapia fotodinâmica em células excitáveis PRAXIS XXI/SAU/1198/95 Researcher Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Associação para a Inovação e Desenvolvimento da FCT Concluded
1995/12/01 - 1996/04/30	MECANISMOS DE MORTE CELULAR DURANTE A TERAPIA FOTODINÂMICA DAS CÉLULAS EXCITÁVEIS PRAXIS XXI/BD/5176/95 Universidade de Coimbra, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Other

	Designation	Funders
2013 - 2014	How does autophagy modulate inflammasome activation? GAI 2014_2 Universidade de Coimbra Faculdade de Medicina, Portugal	Universidade de Coimbra Faculdade de Medicina Concluded

Outputs

Publications

Book	Mendes, Alexandrina Ferreira ; Cruz, Maria Teresa; Gualillo, O.. The Physiology of Inflammation – The Final Common Pathway to Disease. Frontiers Media SA. 2019. 10.3389/978-2-88945-729-8 Babo, Maria Augusta; Pinto, José Gomes; Cruz, Maria Teresa. Tecnologias culturais e Artes dos Media. Lisboa, Portugal: CECL/UnyLeya. 2016. Published Francisco, V.; Costa, G.; Neves, B.M.; Cruz, M.T.; Batista, M.T.. Anti-Inflammatory Activity of Polyphenols on Dendritic Cells. 2013. 10.1016/B978-0-12-398456-2.00028-1
Book chapter	Calmeiro, João; Carrascal, Mylene; Gomes, Célia; Falcão, Amílcar; Cruz, Maria Teresa; Neves, Bruno Miguel. "Highlighting the Role of DC-NK Cell Interplay in Immunobiology and Immunotherapy". In Dendritic Cells. InTech, 2018. 10.5772/intechopen.78804 Francisco, V.; Costa, G.; Neves, B.M.; Cruz, M.T.; Batista, M.T.. "Antiinflammatory activity of polyphenols on dendritic cells". 395-415. 2018. Neves, Bruno Miguel; Martins, João Demétrio; Ferreira, Isabel; Silva, Ana; Cruz, Maria Teresa. "In Vitro Dendritic Cell-Based Test for Skin Sensitizers Identification and Potency Estimation". In Alternatives for Dermal Toxicity Testing, 417-435. Springer International Publishing, 2017. 10.1007/978-3-319-50353-0_29 Cruz, Maria Teresa; Liberal, Joana; Ferreira, Isabel V.; Cardoso, Eliza O.; Silva, Ana; Bartolomeu, Ariane R.; Martins, Joao; et al. "Anti-Inflammatory Activity of the Honeybee Plant- Derived Products Honey, Pollen and Propolis". In Chemistry, Biology and Potential Applications of Honeybee Plant- Derived Products, 313-346. BENTHAM SCIENCE PUBLISHERS, 2016. 10.2174/9781681082370116010012 Francisco, V.; Costa, G.; Neves, B.M.; Cruz, M.T.; Batista, M.T.. "Anti-Inflammatory Activity of Polyphenols on Dendritic Cells". In Polyphenols in Human Health and Disease, 373-392. Elsevier, 2014. 10.1016/b978-0-12-398456-2.00028-1 Cruz, Maria Teresa. "Células dendríticas". In Fundamentos de Imunologia. lidel, 2012. Published Miguel, Bruno; Celeste, Maria; Teresa, Maria. "Pathogen Strategies to Evade Innate Immune Response: A Signaling Point of View". In Protein Kinases. InTech, 2012. 10.5772/37771
Conference abstract	Ramos, Ana Beatriz; Rodrigues, Beatriz; Veloso Colaço, Carolina; Sebastião, AI; Silva, Ana Cristina Rosa da; Neves, Bruno; Cruz, Maria Teresa. "Advancing key event 4 (t-cell activation)-based pbmc methods for non-animal screening of skin and respiratory sensitizers". Paper presented in SOT 65th Annual Meeting and ToxExpo, San Diego, San Diego, 2026. Published Rodrigues, Beatriz; Ramos, Ana Beatriz; Sónia Silva; Rui F.P. Pereira; Fonseca, Ana C.; Coelho, Jorge; Cruz, Maria Teresa; Rita G. Fonseca. "Silk Fibroin Nanoparticles as Drug Carriers: Biocompatibility and Immunological Characterization". Paper presented in SOT 65th Annual Meeting and ToxExpo, San Diego, 2026. Published Gouveia, Filipa; Castanheira, Sara; Cruz, Maria Teresa; Ettcheto, Miren; Fortuna, Ana. "Multi-target neuroprotective effects of Irbesartan in a mouse model of Alzheimer’s Disease". Paper presented in 55ª REUNIÃO DA SOCIEDADE PORTUGUESA DE FARMACOLOGIA, 2025. Faria, Clarissa; Jesus, Sandra; Ferreira, Barbara; Borges, Olga; Cruz, Maria Teresa; Sousa, Maria do Céu Rodrigues. "Use of extracellular vesicles of Giardia lamblia as a promising vaccine candidate". Paper presented in 34th European Congress of Clinical Microbiology and Infectious Diseases, Barcelona, 2024. Faria, Clarissa; Lourenço, Ágata; Bruno Miguel Rodrigues Neves; Girao, Henrique; Ribeiro-Rodrigues, Teresa M; Cruz, Maria Teresa; Sousa, Maria do Céu Rodrigues. "Unveiling the role of extracellular vesicles secreted by Giardia lamblia on innate immune response". Paper presented in First Meeting of the Portuguese Network on Extracellular Vesicles (PNEV), Porto, 2021. Calmeiro J; Carrascal M; Mendes, LF; Duarte, Iola F; Gomes, Célia; Serra J; Falcão A; Cruz MT; Neves, Bruno. "Dendritic-cell based immunotherapy targeting pancreatic and NSCLC cancer stem cells". Paper presented in iTOCC7 - The 7th Leading International Cancer Immunotherapy Conference in Europe - Abstracts published in Journal for ImmunoTherapy of Cancer 8, Suppl2, A36, 2020. Alves-Silva, Jorge; Guerra, Inês; Gonçalves, Maria José; Cavaleiro, Carlos; Cruz, Maria Teresa; Figueirinha, Artur; Salgueiro, Lígia. "Chemical characterization of the hydrodistillation residual water and essential oil of Crithmum maritimum". Paper presented in 11º Encontro Nacional de Cromatografia, Lisboa, 2019. Published Oliveira, AS; Vaz, CV; Silva, A.; Correia, S.; Ferreira, R.; Breitenfeld, L.; Martinez-de-Oliveira, J.; et al. "Portuguese Thermal Waters: in vitro effect on microbial growth and skin cell regeneration". Paper presented in XIII Annual CICS-UBI Symposium, Covilhã, 2018. Published Alves-Silva, Jorge; Zuzarte, Mónica; Gonçalves, Maria José; Cavaleiro, Carlos; Cruz, Maria Teresa. "Óleos essenciais de Daucus carota: marcadores quimiotaxonómicos e agentes bioativos". Paper presented in V Congresso Ibérico de Apicultura 1-3 February 2018, Coimbra, 2018. Gonçalo, Margarida; Martins, João Demétrio; Neves, Bruno Miguel; Silva, Ana Cristina Rosa da; Figueiredo, Américo; Lopes, Maria Celeste; Cruz, Maria Teresa. "As contact sensitizers, drugs causing delayed drug erutpions activate THP-1 cells". Paper presented in 12th Congress of the European Society of Contact Dermatitis, Barcelona, 2014. Published Martins, J.; Neves, Bruno Miguel; Gonçalo, Margarida; Lopes, Maria Celeste; Domingues, M. R.; Cruz, Maria Teresa. "Role of extracelular danger signal adenosine-5’-triphosphate on the 1-fluoro-2,4-dinitrobenzene-induced maturation of THP-1 cells". Paper presented in 42nd Annual ESDR Meeting, Veneza, 2012. Published Neves, Bruno; Silvestre, Ricardo; Cunha, Joana; Tavares, Joana; Resende, Mariana; Ouaissi, Ali; Lopes, MC; Cruz, Maria Teresa; Cordeiro-da-Silva, Anabela. "Immunomodulation of dendritic cells by virulent and attenuated Leishmania infantum strains". Paper presented in 2nd European Congress of Immunology, Berlim, 2009. Published Neves, B.; Francisco, Vera; Cruz, Maria Teresa; Gonçalo, Margarida; Figueiredo, Américo; Duarte, Carlos B.; Lopes, Maria Celeste. "Modulation of CXCR4 by skin sensitizers and irritants in dendritic cells.". Paper presented in 9th ESDC Congress, Estoril, 2008. Published Francisco, Vera; Neves, B.; Cruz, Maria Teresa; Gonçalo, Margarida; Figueiredo, Américo; Duarte, Carlos B.; Lopes, Maria Celeste. "The sensitizer nickel increases thioredoxin in dendritic cells". Paper presented in 9th ESDC Congress, Estoril, 2008. Published Gonçalo, Margarida; Cruz, Maria Teresa; Duarte, Carlos B.; Figueiredo, Américo; Lopes, Maria Celeste. "Immunossupressive drugs in Ni-induced iNOS expression in skin DC". Paper presented in 8th ESCD Congress, Berlim, 2006. Published Cruz, Maria Teresa; Jaleco, S. P.; Duarte, Carlos B.; Gonçalo, Margarida; Figueiredo, Américo; Carvalho A. P.; Lopes, Maria Celeste. "Early cellular events induced by DNFB and DCNB in a fetal skin derived dendritic cell line.". Paper presented in 5th ESCD Congress, Amsterdam, 2000. Published Cruz, Maria Teresa; Gonçalo, Margarida; Duarte, Carlos B.; Carvalho A. P.; Lopes, C.. "A skin derived dendritic cell line produces nitric oxide after stimulation with LPS and GM-CSF.". Paper presented in 6th EADV Congress, Dublin, 1997. Published Cruz, Maria Teresa; Gonçalo, Margarida; Duarte, Carlos B.; Carvalho A. P.; Lopes, Maria Celeste. "Estudo da expressão da isoforma indutiva da sintase do óxido nitrico numa linha celular dendrítica isolada da pele do rato". Paper presented in 1º Congresso de Investigação em Medicina, Coimbra, 1997. Published
Conference poster	Pinho, Sónia A.; Silva, Ana Cristina Rosa da; Carvalho, Eugenia; Azul, Anabela Marisa; Matafome, Paulo; Pereira, Cláudia Fragão; Oliveira, Paulo J.; Cruz, Maria Teresa. "Screening of natural and synthetic mediterranean diet compounds reveals novel anti-obesity candidates via Nrf2 activation". Paper presented in CIM HEALTH 2026 - Coimbra International Meeting in Health Sciences and Technology, 2026. Sandra Mota; Abigail Rodrigues; Smeera Ratanji; Sónia A. Pinho; Clara Quintas; Maria T. Cruz; Isabel F. Almeida; Emilia Sousa. "Development and evaluation of new depigmenting agents using a Safe and Sustainable by Design approach". Paper presented in 16th National Organic Chemistry Meeting (16ENQO) and the 9th National Medicinal and Biological Chemistry Meeting (9ENQMB), 2026. Ramos, Ana Beatriz; Rodrigues, Beatriz; Sebastião, AI; Silva, Ana Cristina Rosa da; Neves, Bruno; Cruz, Maria Teresa. Corresponding author: Ramos, Ana Beatriz. "Development and Enhancement of a Non-Animal Method for Screening Skin and Respiratory Sensitizers". Paper presented in VI MAD Meeting, 2026. Mateus, Daniela; Sebastião, AI; Simões, Gonçalo; Carrascal, Mylène; Neves, Bruno; Sales, Maria Goreti; Gomes, Célia; Cruz, Maria Teresa. "Expanding cytotoxic T cells in an antigen-specific manner using PLGA nanoparticles.". Paper presented in IV ASPIC-ASEICA International Meeting, 2025. Pinho, Sónia A.; Silva, Ana Cristina Rosa da; Sónia Silva; Carvalho, Eugenia; Azul, Anabela Marisa; Matafome, Paulo; Pereira, Cláudia; Oliveira, Paulo J.; Cruz, Maria Teresa. "Exploring Mediterranean Diet-Derived Phytochemicals as Nrf2 Activators to Mitigate Obesity-Related Inflammation". Paper presented in Satellite symposium of the SFRR-I conference NRF2: physiology, pathology, pharmacology, and clinical development. Galway, Ireland, 2025. Morgado, Carolina; 141E-0031-CA54; Cruz, Maria Teresa; 6A1D-22C8-B2A3; Resende, Rosa. "Inflammatory and Senescence-Related Effects of Polyethylene Microspheres on Dermal Cells". Paper presented in IV 1H-TOXRUN International Conference 2025, 2025. Ferreira, Bárbara; Cruz, Maria Teresa; Borges, Olga; Sousa MC. Corresponding author: Ferreira, Bárbara. "DEVELOPMENT OF A GIARDIA VACCINE". Paper presented in EAFP - Annual Conference 2025 "Pharmaceutical Education and Research: SWOT Analysis", 13-15 May 2025, Coimbra, 2025. Rodrigues, Beatriz; Ana Beatriz Ramos; Manuela F. Frasco; Ana C. Fonseca; M. Goreti F. Sales; Cruz, Maria Teresa; Silva, Ana Cristina Rosa da. "ChemSensing – A biosensor to detect human sensitizers". Paper presented in SOT 64th Annual Meeting and ToxExpo, 2025. Alvarenga, Brendo; Simões, Gonçalo; Sebastião, AI; Mateus, Daniela; Carrascal, Mylène A.; Gomes, Célia; Cruz, Maria Teresa. "Obtaining Peptide-Specific CD8+ T Cells to Evaluate the Efficacy of Dendritic Cell-based Vaccines Against Cancer". Paper presented in V Metabolism, Aging and Disease meeting, 5th CIBB retreat, 2025. Pinho, Sónia A.; Silva, Ana Cristina Rosa da; Sónia Silva; Carvalho, Eugenia; Azul, Anabela Marisa; Matafome, Paulo; Pereira, Cláudia; Oliveira, Paulo J.; Cruz, Maria Teresa. "Investigating Nrf2 Modulation by Mediterranean Diet Compounds in the Context of Obesity-Driven Inflammation". Paper presented in V Metabolism, Aging & Disease Meeting, From prevention to personalized medicine: empowering the citizen, 2025. Rodrigues, Beatriz; Ana Beatriz Ramos; Manuel F. Frasco; Ana C. Fonseca; M. Goreti F. Sales; Cruz, Maria Teresa; Silva, Ana Cristina Rosa da. "Development of a non-animal method for screening respiratory sensitizers". Paper presented in V Metabolism, Aging and Disease meeting, 5th CIBB retreat, 2025. Luísa Medeiros; Resende, Rosa; Pereira, Cláudia Maria Fragão; Cruz, Maria Teresa; Silva, Ana Cristina Rosa da. "Unraveling the Key Mechanisms ofPolyethylene Nanoplastics Toxicity in Skin". Paper presented in V Metabolism, Aging and Disease meeting, 5th CIBB retreat, 2025. Moutinho, Inês; Pinho, Sónia A.; Silva, Ana Cristina Rosa da; Rodrigues, Beatriz; Cavadas, Claudia; Cruz, Maria Teresa. "Effect of the NRF2 activator Isoeugenol on UV-induced inflammation and cell death". Paper presented in V Metabolism, Aging & Disease Meeting, From prevention to personalized medicine: empowering the citizen, 2025, 2025. Pinho, Sónia A.; Silva, Ana Cristina Rosa da; Sónia Silva; Carvalho, Eugenia; Azul, Anabela Marisa; Matafome, Paulo; Pereira, Cláudia; Oliveira, Paulo J.; Cruz, Maria Teresa. "Evaluating Nrf2-Activating Compounds from the Mediterranean Diet for Anti-Inflammatory Potential in Obesity-Related Inflammation". Paper presented in 8th BenBedPhar Scientific Meeting, 2024. Cláudia Cid; Rodrigues, Beatriz; Resende, Rosa; Carrascal, Mylène A.; Maria do Céu Sousa; Conceição Egas; Pereira, Cláudia Maria Fragão; et al. "Effect of LUSO’s thermal water on LPS-induced macrophage inflammation". Paper presented in 32nd Annual GP2A Meeting, 2024. Páscoa, Ricardo; Mota, Sandra; Torres, Ana; Joana Rocha e Silva; Agostinho Almeida; Helena N. Ferreira; Cruz, Maria Teresa; Isabel F. Almeida. Corresponding author: Isabel F. Almeida. "Unlocking the Potential of Cork Powder: Sustainable Sourcing for the Cosmetic Industry.". Paper presented in Cosmetinnov, 2024. Marques, Mário Pedro; Euclides Landim; Varela, Carla; Marques, Joana; da Costa, Ricardo MF; Luís A. E. Batista de Carvalho; Silva, Ana Cristina Rosa da; et al. Corresponding author: Marques, Mário Pedro. "Valuing the medicinal flora of Côa valley (Portugal) through the development of new plant- based cosmetics". Paper presented in 72nd International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), 2024. Marques, Mário; Varela, Carla; da Costa, Ricardo MF; Luís A. E. Batista de Carvalho; Silva, Ana Cristina Rosa da; Cruz, Maria Teresa; Dias, Maria Inês; et al. "Are the hydroethanolic extracts from Côa Valley aromatic plants a promising source of cosmetic bioactive ingredients?". Paper presented in COSMETINNOV - The Next Gen of Beauty, 3rd ed., 2024. Panão Costa, João; Colaço, Mariana; Félix, Paulo; Melo, Alexandra; Lebre, Filipa; Cruz, Maria Teresa; Alfaro-Moreno, Ernesto; Moreira, João Nuno; Borges, Olga. "ß-glucan polymeric microparticles: innovating cancer immunotherapy through targeted antigen delivery". Paper presented in 6th ASPIC International Congress, 2024. Rodrigues, Beatriz; Eduarda Ventua; Moreira, Patricia; Resende, Rosa; Armanda E. Santos; Pereira, Cláudia Maria Fragão; Cruz, Maria Teresa; et al. "NEW LOW-DOSE CURCUMIN DERIVATIVES WITH THERAPEUTIC POTENTIAL IN ALZHEIMER’S DISEASE". Paper presented in AD/PD™ 2024 International Conference on Alzheimer’s and Parkinson’s Diseases, 2024. Marques, Mário P.; Varela, Carla; da Costa, Ricardo MF; Marques, Joana; Luís A. E. Batista de Carvalho; Silva, Ana Cristina Rosa da; Cruz, Maria Teresa; et al. "Searching for cosmetic ingredients in strawberry-tree leaves’ and turpentine-tree fruits’ extracts". Paper presented in IV Metabolism Aging & Disease (MAD) Meeting - Disease and Therapeutics: from the Past to Future, 2024. Gouveia, Filipa; Fonseca, Carla; Bicker, Joana; Camins, Antoni; Cruz, Maria Teresa; Ettcheto, Miren; Fortuna Ana. "Intranasal Administration of Irbesartan as a New Strategy for Addressing Neurodegeneration in a Neuroinflammation Mice Model: Pharmacokinetic and Efficacy Evaluation". Paper presented in Congresso do Núcleo de Estudantes de Farmácia da Associação Académica de Coimbra, 2024. SIlva AP; Fernandes AO; Ormonde A; Sanches, ES; Valls R; Silva A; Almeida J; et al. "Neurovascular and immune alterations associated with psychostimulants use: a pre-clinical study". Paper presented in XVII Congresso Nacional de Psquiatria, 2023. Sebastião, AI; Oliveira, Filomena; Simões, Gonçalo; Mateus, Daniela; Gomes, Célia; Neves, Bruno; Carrascal, Mylène A.; Cruz, Maria Teresa. Corresponding author: Cruz, Maria Teresa. "Dendritic cells loaded with cancer-testis antigens to halt triple-negative breast cancer". Paper presented in III ASPIC-ASEICA International Meeting, 2023. Gouveia, Filipa; Bicker, Joana; Carona, Andreia; Ettcheto, Miren; Cruz, Maria Teresa; Fortuna, Ana. "Ultra High Performance Liquid Chromatography Technique to support Pharmacokinetic Monitoring of Losartan, Irbesartan and Valsartan". Paper presented in X Congresso Iberoamericano de Ciências Farmacêuticas, 2023. Santos B; Afonso M; Alves A; Amaral S; Candeias E; Cardoso M; Cortes L; et al. "GreenLabs @CIBB - One path for sustainable research". Paper presented in Green Labs Portugal Symposium: Promoting sustainability in Research, 2023. Susano, Patrícia; Silva, Joana; Alves, Celso; Martins, Alice; Pinteus, Susete; Cruz, Maria Teresa; Gabig-Ciminska, Magdalena; Pedrosa, Rui. "Cytotoxic and anti-inflammatory effects of seaweed-derived compounds in human keratinocytes (HaCaT cells)". Paper presented in International Symposium on Marine Natural Products and European Conference on Marine Natural Products, 2023. Fernandes AO; Sanches, Eliane Swely; Cruz MT; Ana Paula Pereira da Silva Martins. "Methamphetamine-induced drug-seeking behaviour: impact on CCL5/CCR5 axis". Paper presented in FENS Regional Meeting 2023, 2023. Mota, Sandra; Silva, José Paulo ; Pinto, Cláudia; Torres, A; Rego, Liliana; Cravo, Sara; Afonso, Carlos; et al. "A tríade de sustentabilidade do Quercus Suber como fonte de ingredientes cosméticos: Longevidade, Regeneração e Upcycling". Paper presented in XXVI COLAMIQC 2023, 2023. Faria, Clarissa Perez; Ferreira, Bárbara; Ágata Lourenço; Mateus, Daniela; Sebastião, Ana Isabel; Neves, Bruno; Cruz, Maria Teresa; Maria do Céu Rodrigues de Sousa. Corresponding author: Maria do Céu Rodrigues de Sousa. "Extracellular Vesicles of Giardia lamblia modulate host cell innate immunity: new avenues for the exploitation of novel therapies". Paper presented in 33rd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), 2023. Sebastião, AI; Oliveira, Filomena; Simões, Gonçalo; Mateus, Daniela; Gomes, Célia; Neves, Bruno; Carrascal, Mylène A.; Cruz, Maria Teresa. Corresponding author: Cruz, Maria Teresa. "Dendritic Cell-Loading Vaccine With Cancer-Testis Antigens To Halt Triple-Negative Breast Cancer Cell". Paper presented in XLVIII SPI Annual Meeting 2023, 2023. Ana Sofia Oliveira; Cátia Vaz; Carolina Proença Gomes; Rolo, Joana; Palmeira-de-Oliveira, Rita; Ana Silva; Cláudia Pereira; Cruz, Maria Teresa; Oliveira, Ana Cristina Palmeira de. "The potential of Portuguese Thermal Waters as cosmetic ingredients for fragilized skin with a focus on skin repairing activity". Paper presented in OncoSkin: I Congresso de Skincare, Estética e Dermocosmética em Oncologia, 2023. Pereira, Ana Catarina; Marques, Ana Patrícia; Resende, Rosa; Serrano-Cuñarro, Laura; Batista, Mariana; Macedo, António; Pais, Cláudia; et al. "The role of mitochondria-associated membranes (MAMs) in bipolar disorder.". Paper presented in BEBday, University of Coimbra, Coimbra, Portugal., 2023. Mateus, Daniela; Sebastião, AI; Frasco, Manuela F; Carrascal, Mylène; Neves, Bruno; Gomes, Célia; Sales, Maria Goreti; Cruz, Maria Teresa. "Functionalized PLGA-lipid hybrid nanoparticles for targeted drug delivery". Paper presented in SUPRAlife Functional Supramolecular Polymeric Biomaterials, 2023. Mateus, Daniela; Sebastião, Ana Isabel; Carrascal, Mylène; Cortes, Luisa; Carmo, Anália; Matos, Ana Miguel; Maria Goreti Ferreira Sales; Cruz, Maria Teresa. Corresponding author: Cruz, Maria Teresa. ""SARS-CoV-2, Dendritic Cells, and Immunity: the connected dots"". Paper presented in BEB day, 2022. MoreiraP; Macedo, Jéssica; Figueirinha A; Salgueiro L; Batista MT; Silva S; Branco PC; Cruz MT; Pereira CF. "Protective effects of extracts from Eucalyptus globulus biomass in Alzheimer's disease in vitro and in vivo models. Beneficial effects of compounds extracted from Eucalyptus globulus biomass on skin health.". Paper presented in Iberoamerican Congress on Pulp and Paper Research (CIADICYP), Girona, 2022. Moreira, Patricia; Macedo, Jéssica; Figueirinha, Artur; Salgueiro, Lígia; Batista, Maria Teresa; Silva, Sónia; Branco, Pedro Costa; Cruz, Maria Teresa; Pereira, Cláudia Fragão. "Neuroprotective properties of extracts from Eucalyptus globulus biomass and its beneficial effects in an Alzheimer's disease mouse model". Paper presented in 16th International Conference on Alzheimer's & Parkinson's Diseases, Barcelona, Spain, 2022. Silva, Ana Cristina Rosa da; Pereira, Marta; Carrascal, Mylene; Brites, Gonçalo Sousa; Neves, Bruno; Moreira, Patricia; Resende, Rosa; et al. "EFFECT OF SKIN ALLERGENS TARGETING NRF2 TRANSCRIPTION FACTOR ACTIVATION ON ALZHEIMER’S DISEASE HALMARKS". Paper presented in 15th International Conference on Alzheimer's and Parkinson's Diseases (ADPD2021), 2021. Moreira, Patricia; Figueirinha, Artur; Salgueiro, Lígia; Batista, Maria Teresa; Silva, Sónia; Branco, Pedro Costa; Cruz, Maria Teresa; Pereira, Cláudia Fragão. "Effects of extracts from forestry biomass in Alzheimer's disease in vitro and in vivo models: interplay between bioeconomy and health benefits". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, Coimbra, Portugal, 2021. Matos, Patricia; Santos, A. C.; Nunes, F.; Cruz, Maria Teresa; Batista, Maria Teresa; Figueirinha, Artur. "Chemical characterization and biological activities of infusion from Acanthus mollis leaves". Paper presented in International IBERPHENOL Conference “Advances in the role of phenols in health effects and other uses”, 2020. Moreira, Patricia; Gonçalves, Maria José; Cavaleiro, Carlos; Figueirinha, Artur; Salgueiro, Lígia; Batista, Maria Teresa; Branco, Pedro Costa; Cruz, Maria Teresa; Pereira, Cláudia Fragão. "Chemical composition and bioactivity of phenolic compounds extracted from Eucalyptus globulus biomass". Paper presented in IberPhenol - International Conference, Coimbra, Portugal, 2020. Calmeiro, João; Mylène Carrascal; Luis Mendes; Iola F. Duarte; Célia Gomes; João Serra; Amílcar Falcão; Cruz, Maria Teresa; Neves, Bruno. "Dendritic cell plasticity in cancer immunotherapy: functional and metabolic characterization of the impact of different GMP serum-free media in human-monocyte-derived DCs". Paper presented in 1st Meeting of the French Society of Cancer Immunotherapy, Institut Curie, Paris, France, 2019. Sousa, Fábio J.; Carrascal, Myléne A.; Moreira, Paula I.; Santos, Armanda E.; Cruz, Maria Teresa; Pereira, Cláudia. "Impact of Endoplasmic Reticulum stress on neuronal mitochondria". Paper presented in 1st Annual Meeting in Pharmaceutical Sciences, Coimbra, Portugal, 2019. Moreira, Patricia; Gonçalves, Maria José; Cavaleiro, Carlos; Figueirinha, Artur; Salgueiro, Lígia; Batista, Maria Teresa; Branco, Pedro Costa; Cruz, Maria Teresa; Pereira, Cláudia Fragão. "Antifungal activity and cytotoxicity evaluation of phenolic compounds extracted from Eucalyptus globulus biomass". Paper presented in Iberian Congress of Phenolic Compounds, Ourense, Spain, 2019. Silva, Ana; Pereira, Marta; Brites, Gonçalo; Neves, Bruno; Moreira, Patricia; Resende, Rosa; Silva, Maria Manuel; et al. "Skin allergens and Alzheimer´s disease: preliminary studies on an (im)probable link". Paper presented in Cell Signalingin Aging and Neurodegenerative Diseases, Coimbra, Portugal, 2019. Moreira, Patricia; Gonçalves, Maria José; Cavaleiro, Carlos; Figueirinha, Artur; Salgueiro, Lígia; Batista, Maria Teresa; Branco, Pedro Costa; Cruz, Maria Teresa; Pereira, Cláudia Fragão. "Determination of safe bioactive doses of essential oil and phenolic compounds extracted from Eucalyptus globulus leaves". Paper presented in Natural Products in Drug Discovery and Human Health (NatProdDDH) – PSE Meeting, Lisbon, Portugal, 2019. Calmeiro, João; Mylène Carrascal; Luis Mendes; Iola F. Duarte; Célia Gomes; João Serra; Amílcar Falcão; Cruz, Maria Teresa; Neves, Bruno. "Impact of different GMP serum-free media in the plasticity of dendritic cells for clinical use in cancer immunotherapy". Paper presented in 26th Porto Cancer Meeting & Porto-Bordeaux joint meeting: the cancer ecosystem, i3S – Instituto de Investigação e Inovação em Saúde, Porto, Portugal, 2019. Calmeiro, João; Mylène Carrascal; Luis Mendes; Iola F. Duarte; Célia Gomes; João Serra; Amílcar Falcão; Cruz, Maria Teresa; Neves, Bruno. "Dendritic cells plasticity for clinical use in cancer immunotherapy: functional and metabolic characterization of the impact of different GMP serum-free media in monocyte-derived dendritic cells.". Paper presented in 5th Workshop on Dendritic Cell Biology: antitumoral immunotherapy, from biology to the clinic. Champalimaud Foundation, Lisbon, Portugal, 2019. Pereira, Ana Catarina; Ferreira, Isabel; Neves, Bruno; Morais, S; Madeira, N; Cruz, Maria Teresa; Pereira, Cláudia. "Mitochondria-Associated Membranes: the putative link between cellular stress and inflammasome activation in Bipolar Disorder". Paper presented in Encontro Nacional da Sociedade Portuguesa de Psiquiatria e Saúde Mental (SPPSM)\| II Encontro das Secções, 2019. Pereira, Marta; Silva, Ana; Neves, Bruno; Moreira, Patricia; Silva, Maria Manuel; Santos, Armanda Emanuela; Pereira, Cláudia Fragão; Cruz, Maria Teresa. "Molecules with an improbable therapeutic application for Alzheimer’s disease". Paper presented in Ageing: models, mechanisms and therapies, Coimbra, Portugal, 2019. Faria CP; Neves BM; Lourenço A; Cruz MT; Martins JD; Ana Silva; Pereira, Sónia; Sousa MC. "Giardia lamblia modulates LPS-induced pro-inflammatory response in macrophages through cleavage of NF-kB p65RelA by proteases". Paper presented in MicroBiotec19 - Congress of Microbiology and Biotechnology, 2019. Sousa, Fábio J.; Carrascal, Mylene; Moreira, Paula Isabel; Santos, Armanda E; Cruz, Maria Teresa; Pereira, Cláudia. "Impact of ER stress on neuronal mitochondria". Paper presented in 1st Annual Meeting in Pharmaceutical Sciences, 2019. Brites , Gonçalo; Filipa, Silva; Ferreira, Isabel; Silva, Ana; Mylène A. Carrascal; Miguel Neves, Bruno; Cruz, Maria Teresa. "Managing allergic contact dermatitis: screening of molecules with potential for preventing the disease". Paper presented in 24th World Congress of Dermatology, 2019. Palmeira-de-Oliveira, Rita; Oliveira, A.S.; Vaz CV; Correia S.; Ferreira R.; Breitenfeld, L.; JMO - 8812-C62C-364F; et al. "The anti-inflammatory and anti-aging properties of Portuguese thermal waters". Paper presented in IV Congresso Científico Anual UBIPharma - Inovar e Reinventar a Prática Farmacêutica, 2018. Pereira, Ana Catarina; Ferreira, Isabel; Neves, Bruno; Madeira, N; Cruz, Maria Teresa; Pereira, Cláudia. "Resposta ao stresse celular em células do sistema imune inato na doença Bipolar". Paper presented in 2º Semina´rio da Sociedade Portuguesa para o Estudo da Saúde Mental - SPESM, 2018. Ferreira, Isabel; Silva, Ana Cristina Rosa da; Martins, João Demétrio; Neves, Bruno Miguel; Cruz, Maria Teresa. "Respiratory and skin allergies: a matter of differential ROS origin and kinetics?". Paper presented in 14th Congress European Society of Contact Dermatitis, 2018. Oliveira, AS; Vaz CV; Silva A; Correia S; Ferreira R; Breitenfeld L; Martinez-de-Oliveira J; et al. "Antimicrobial activity and regenerating and healing properties of Portuguese thermal waters". Paper presented in 30TH IFSCC CONGRESS. Munich, Germany, 2018. Palmeira-de-Oliveira, A; Silva AC; Vaz CV; Oliveira, AS; Correia S; Ferreira R; Breitenfeld L; et al. "Anti-inflammatory activity of portuguese thermal waters". Paper presented in 54th Congress of the European Societies of Toxicology (EUROTOX 2018). Brussels, Belgium, 2018. Matos, Patricia; Figueirinha, Artur; Paranhos, António; Nunes, F.; Ferreira, I.; Cruz, Maria Teresa; Batista, Maria Teresa. "Antioxidant and Anti-inflammatory Activities of Phenolic Compounds from Acanthus mollis". Paper presented in XXIXth International Conference on Polyphenols, 2018. Vaz CV; Silva AC; Oliveira, AS; Correia S; Ferreira R; Breitenfeld L; Martinez-de-Oliveira J; et al. "In vitro effect of portuguese thermal waters on inflammation biomarkers". Paper presented in XIII Annual CICS-UBI Symposium. Covilhã. Portugal, 2018. Pereira, Ana Catarina; Ferreira, Isabel; Neves, Bruno; Cruz, Maria Teresa; Pereira, Cláudia. "Role of Mitochondria-Associated Membranes in the endoplasmic reticulum stress response in the innate immune system". Paper presented in MitoPorto International Symposium, 2018. Oliveira, AS; Vaz CV; Silva AC; Correia S; Ferreira R; Breitenfeld L; Martinez-de-Oliveira J; et al. "Effect of Portuguese Thermal Waters on Cell Viability and against Skin Commensal and Pathogenic Microorganisms". Paper presented in V Congresso da Sociedade Portuguesa de Ciências Cosmetológicas (COSMETINNOV). Porto, Portugal, 2018. Martins, VMR; Simões, J; Ferreira, Isabel; Cruz, Maria Teresa; Domingues, MR; Coimbra, MA. "The polysaccharides from Pterospartum Tridentatum (L.) willk. inflorescences and their contribution to in vitro macrophage nitric oxide production". Paper presented in XIXth EuroFoodChem Conference, 2017. Ferreira, Isabel; Silva, Ana Cristina Rosa da; Martins, João Demétrio; Neves, Bruno Miguel; Cruz, Maria Teresa. "Differential modulation of toxicity pathways by respiratory and cutaneous allergens: interaction with physiopathology". Paper presented in International Conference on Occupational & Environmental Toxicology, ICOETOX, 2016. Célia Cabral; Miranda, Margarida; M. J. Gonçalves; Cavaleiro, Carlos; Cruz, Maria Teresa; Ligia Salgueiro. "Essential oil of the Portuguese endemic Santolina impressa Hoffmanns. & Link: assessment of antifungal safe doses". Paper presented in 6th International Congress of Aromatic and Medicinal Plants (CIPAM2016), 2016. Martins, Vitor MR; Simões, Joana; Ferreira, Isabel; Cruz, Maria Teresa; Domingues, Maria Rosário; Coimbra, Manuel A. "Structural characterization and macrophage immunostimulatory activity of polysaccharides present in the hot water extracts from P. tridentatum dried inflorescences.". Paper presented in 3rd International Congress on Cocoa, Coffee and Tea, 2015. Martins, Vitor MR; Simões, Joana; Ferreira, Isabel; Cruz, Maria Teresa; Domingues, Maria Rosário; Coimbra, Manuel A. "Structural features and macrophage immunostimulatory activity of the polysaccharides from Fraxinus angustifolia and Mentha suaveolens hot water extracts". Paper presented in 3rd International Congress on Cocoa, Coffee and Tea, 2015. Abu-Darwish, MS; Cabral, Célia; Ferreira, Isabel; Gonçalves, MJ; Cavaleiro, Carlos; Cruz, Maria Teresa; Al-bdour, TH; Salgueiro, Lígia. "Essential oils of Salvia officinalis L. from Jordan: Assessment of safety in mammalian cells, and their antifungal and anti-inflammatory potential". Paper presented in 5th International Congress on Medicinal and Aromatic Plants ¿ CIPAM 2014, 2014. Liberal, Joana; Costa, Gustavo; Carmo, Anália; Cruz, Maria Teresa; Batista, Maria Teresa; Liberal, J.T.; Costa, G; et al. "Ellagitannin-enriched fraction from Fragaria vesca leaves inhibits proliferation and induces cell cycle arrest in the human hepatocellular carcinoma cell line HepG2". Paper presented in 8th World Congress on Polyphenols Applications - ISANH, 2014. 10.1055/s-0033-1352234 Martins, Vitor MR; Ferreira, Isabel; Cruz, Maria Teresa; Batista, Maria Teresa; Coimbra, Manuel A. "Pectic polysaccharides from the infusions of P. tridentatum, F. angustifolia and M. suaveolens: structural characterization and modulation of the inflammatory activity". Paper presented in 2nd International Congress on Cocoa, Coffee and Tea, 2013. Costa, Gustavo; Francisco, Vera; Liberal, Joana; Cruz, Maria Teresa; Lopes, Maria Celeste; Batista, Maria Teresa. "Inhibition of proteasome system by natural compounds: source of new anti-inflammatory and anti-cancer drugs". Paper presented in 6th European Congress of Pharmacology, 2012. Resende, Mariana; Moreira, Diana; Cunha, Joana; Augusto, J; Neves, Bruno; Cruz, Maria Teresa; Estaquier, Jerôme; Cordeiro-da-Silva, Anabela; Silvestre, Ricardo. "Leishmania-infected mature dendritic cells polarize CD4+ T cells towards a non-protective T-bet+ INF-gamma+ IL10+ phenotype". Paper presented in 3rd I3S Scientific Retreat, 2012. Gonçalo, Margarida; Coutinho, I.; Martins, J.; Neves, B.; Silva, Ana; Nunes, R.; Martinho, A.; Cruz, Maria Teresa; Lopes, Maria Celeste. "Severe adverse drug reactions from allopurinol. In vivo and in vitro studies to understand pathophysiology". 2012. Saraiva, Susana; Pereira, Olivia; Liberal, Joana; Batista, Maria Teresa; Domingues, Maria Rosário; Cruz, Maria Teresa; Cardoso, Susana M.. "Antioxidant and anti-inflammatory activities of cytisus multiflorus". Paper presented in CEF 2012, 2012. Resende, Mariana; Moreira, Diana; Cunha, Joana; Neves, Bruno; Costa-Lima, Sofia; Cruz, Maria Teresa; Cordeiro-da-Silva, Anabela; Silvestre, Ricardo. "Infected but not Bystander Dendritic Cells polarize CD4+ T cells towards a non-protective T-bet+ INF-gamma+ IL10+ phenotype". Paper presented in XXXVII Annual Meeting of the Portuguese Society for Immunology, 2011. Rosa, Susana Carvalho; Neves, B.; Gonçalo, Margarida; Domingos, M. R.; Santinha, D.; Macedo, B.; Lopes, Maria Celeste; et al. "Modulation of sphingosine-1 receptors by LPs and the contact allergen PPD". 2011. Neves, B.; Rosa, Susana Carvalho; Gonçalo, Margarida; Martins, J.; Lopes, Maria Celeste; Cruz, Maria Teresa. "A in vitro cell test for skin sensitizers based on the analysis of gene expression and cell signaling pathways". 2011. Liberal, Joana; Francisco, Vera; Santos, Tânia; Marques, Carla; Lopes, Maria Celeste; Cruz, Maria Teresa; Batista, Maria Teresa. "Targeting proteasome with Fragaria vesca extract". Paper presented in Conference CEF 2011, 2011. Resende, Mariana; Silvestre, Ricardo; Neves, Bruno; Cunha, Joana; Cruz, Maria Teresa; Cordeiro-da-Silva, Anabela. "Differential effect of Leishmania infantum on infected and bystander dendritic cells". Paper presented in XXXVI Annual Meeting of the Portuguese Society for Immunology, 2010. Neves, Bruno; Silvestre, Ricardo; Cunha, Joana; Tavares, Joana; Resende, Mariana; Ouaissi, Ali; Lopes, MC; Cruz, Maria Teresa; Cordeiro-da-Silva, Anabela. "Poster PA11/60 Immunomodulation of dendritic cells by virulent and attenuated Leishmania infantum strains". Paper presented in European Congress of Immunology 2009, 2009. Ralha, T.; Jacinto, N.; Gonçalo, Margarida; Cruz, Maria Teresa; Figueiredo, Américo; Lopes, Maria Celeste. "Expressão da iNOS induzida por alergenos em células dendríticas da pele". 2006. Jacinto, N.; Ralha, T.; Gonçalo, Margarida; Cruz, Maria Teresa; Figueiredo, Américo; Lopes, Maria Celeste. "Efeito de imunossupressores na expressão de iNOS induzida pelo níquel em células dendríticas da pele". 2006. Cruz, Maria Teresa; Gonçalo, Margarida; Figueiredo, Américo; Duarte, Carlos B.; Lopes, Maria Celeste. "Effect of immunossupressive drugs on nitric oxide production induced by skin sensitizers". 2006. Cruz, Maria Teresa; Sagradas, J.; Gonçalo, Margarida; Duarte, Carlos B.; Lopes, Maria Celeste. "Transcription factor NF-¿B activation in skin dendritic cells". 2005. Gonçalo, Margarida; Vital, A. L.; Cruz, Maria Teresa; Lopes, Maria Celeste; Figueiredo, Américo. "Dexamethasone inhibits dendritic cell activation by skin sensitizers". 2004. Cruz, Maria Teresa; Vital, A. L.; Gonçalo, Margarida; Duarte, Carlos B.; Lopes, Maria Celeste. "The contact sensitizer nickel sulfate activates the transcription factors NF-kB and AP-1 and increases the expression of the inducible isoform of nitric oxide synthase in a skin dendritic cell line". 2003. Vital, A. L.; Cruz, Maria Teresa; Gonçalo, Margarida; Duarte, Carlos B.; Lopes, Maria Celeste. "Nitric oxide synthase type II expression and NF-kB activation by GM-CSF in a skin dendritic cell line". 2003. Vital, A. L.; Gonçalo, Margarida; Cruz, Maria Teresa; Duarte, Carlos B.; Lopes, Maria Celeste. "Expression of CD40 costimulatory molecule and IL-12 receptor induced by the sensitizers nickel and dinitrofluorobenzene in a fetal skin dendritic cell line". 2003. Cruz, Maria Teresa; Gonçalo, Margarida; Figueiredo, Américo; Carvalho A. P.; Duarte, Carlos B.; Lopes, Maria Celeste. "The contact sensitizer nickel activates the transcritpion factors NF-kB and AP-1 and induces the expression of nitric oxide synthase in a skin dendritic cell line". 2002. Lopes, Maria Celeste; Vital, A. L.; Cruz, Maria Teresa; Gonçalo, Margarida; Duarte, Carlos B.; Figueiredo, Américo; Carvalho A. P.. "GM-CSF activates PKC and PI3K and induces the expression of the nitric oxide synthase type II in a mouse dendrtitic cell line". 2002. Vital, A. L.; Gonçalo, Margarida; Cruz, Maria Teresa; Duarte, Carlos B.; Figueiredo, Américo; Carvalho A. P.; Lopes, Maria Celeste. "GM-CSF activates Pi3 kinase and induces the expression of the nitric oxide synthase type II in a mouse dendritic cell line". 2002. Vital, A. L.; Gonçalo, Margarida; Figueiredo, Américo; Carvalho A. P.; Duarte, Carlos B.; Lopes, Maria Celeste; Cruz, Maria Teresa. "Expression of CD40 costimulatory molecule and IL-12 receptor induced by the sensitizers nickel and dinitrofluorbenzene in a fetal skin dendritic cell line". 2002. Vital, A. L.; Cruz, Maria Teresa; Gonçalo, Margarida; Duarte, Carlos B.; Figueiredo, Américo; Carvalho A. P.; Lopes, Maria Celeste. "The sensitizer dinitrofluorbenzene induces the expression of CD40 and IL-12 receptor in a fetal skin dendritic cell line". 2001. Cruz, Maria Teresa; Carvalho, J. N. P.; Gonçalo, Margarida; Lopes, Maria Celeste. "The skin irritant tributyl causes cell death of a skin dendritic cell line". 2000. Cruz, Maria Teresa; Duarte, Carlos B.; Gonçalo, Margarida; Carvalho A. P.; Lopes, Maria Celeste. "The colony stimulating factor GM-CSF activates transcritpion factors and induces the NO synthase type II expression in a mouse skin dendritic cell line". 2000. Cruz, Maria Teresa; Duarte, Carlos B.; Gonçalo, Margarida; Carvalho A. P.; Lopes, Maria Celeste. "Intracellular signalling involved in nitric oxide production by a skin dendritic cell line activated by GM-CSF". 2000. Cruz, Maria Teresa; Duarte, Carlos B.; Gonçalo, Margarida; Carvalho A. P.; Lopes, Maria Celeste. "Signal transduction for the expression of the inducible NO synthase induced by LPS in a fetal skin dendritic cell line". 1999.
Edited book	Cruz, Maria Teresa; Silva Babo, Maria Augusta Pérez da ; Pinto, José G., ed. CRUZ, M.Teresa, BABO, M. Augusta, PINTO, José G. (org.) (2016) Tecnologias Culturais e Artes dos Media, Lisboa, Rio de janeiro: Leya / Unyleya (e-book) (ISBN BR: 978-85441-0493-4 / ISBN PT: 9789899850361). 2016. Published
Journal article	Marques, Mário Pedro; Landim, Euclides; Varela, Carla; da Costa, Ricardo M. F.; Marques, Joana; Batista de Carvalho, Luís A. E.; Silva, Ana; et al. "Targeting Skin Aging Hallmarks In Vitro: Antioxidant, Anti-Inflammatory, and Anti-Senescence Effects of Phenolic-Rich Extracts from Cistus L. Species". Antioxidants 15 1 (2026): 149. https://doi.org/10.3390/antiox15010149. Published • 10.3390/antiox15010149 Rodrigues, Beatriz; Sónia Silva; Cruz, Maria Teresa. "From Nature to Clinic: Immunological Safety and Biodegradability of Silk Fibroin Nanoparticles". Biomaterials (2026): Submitted Jéssica Lopes; Maria Teresa Cruz; Fernando Ramos; Juliana R. Dias. "Electrospun nanofibers and electrical stimulation: a synergistic approach for chronic wound management". Journal of Materials Chemistry B (2026): https://doi.org/10.1039/D5TB02803E. 10.1039/D5TB02803E Marques, Mário Pedro; Landim, Euclides; Varela, Carla; da Costa, Ricardo M. F.; Marques, Joana; Batista de Carvalho, Luís A. E.; Silva, Ana; et al. "A Spectrochemically Driven Study: Identifying Phenolic-Rich Extracts from Helichrysum stoechas, Lavandula pedunculata, and Thymus mastichina with Potential to Revert Skin Aging Effects". Pharmaceuticals 18 12 (2025): 1889. https://doi.org/10.3390/ph18121889. 10.3390/ph18121889 Mariana Esteves; Ana Miguel Matos; Maria Teresa Cruz. "Oncolytic viruses: A novel therapeutic approach for pancreatic cancer". Molecular Therapy Oncology (2025): https://doi.org/10.1016/j.omton.2025.201069. 10.1016/j.omton.2025.201069 Colaço, M.; Panão-Costa, João; Cruz, Maria Teresa; de Almeida, Luís Pereira; Borges, Olga. "Optimizing mucosal vaccination: Exploiting Lactobionic acid-modified chitosan for superior gene delivery systems". International Journal of Biological Macromolecules 327 (2025): 147492. https://doi.org/10.1016/j.ijbiomac.2025.147492. 10.1016/j.ijbiomac.2025.147492 Pereira, Ana; Marques, Ana; Resende, Rosa; Serrano-cuñarro, Laura; Caldeira, Margarida; Fernandes, Tânia; Batista, Mariana; et al. "Changes in the endoplasmic reticulum-mitochondria communication in dermal fibroblasts from early-stage bipolar disorder patients: Skin-brain axis as a new route to understand the pathophysiology of mental illness?". International Journal of Molecular Medicine 56 6 (2025): 1-16. https://doi.org/10.3892/ijmm.2025.5654. 10.3892/ijmm.2025.5654 Panão-Costa, João; Colaço, M.; Jesus, Sandra; Lebre, Filipa; Cruz, Maria T.; Alfaro-Moreno, Ernesto; Borges, Olga. "Yeast-Derived Glucan Particles: Biocompatibility, Efficacy, and Immunomodulatory Potential as Adjuvants and Delivery Systems". Pharmaceutics 17 8 (2025): 1032. https://doi.org/10.3390/pharmaceutics17081032. 10.3390/pharmaceutics17081032 Ana Jesus; Sara Gimondi; Sónia A. Pinho; Helena Ferreira; Nuno M. Neves; Andreia Palmeira; Emília Sousa; et al. "Macroalgae-Inspired Brominated Chalcones as Cosmetic Ingredients with the Potential to Target Skin Inflammaging". Marine Drugs (2025): https://doi.org/10.3390/md23070278. 10.3390/md23070278 Filipa Gouveia; Marina Carrasco Pérez; Joana Bicker; Ana Silva; Armanda E. Santos; Cláudia Fragão Pereira; Antoni Camins; et al. "Protective effects of irbesartan against neurodegeneration in APP/PS1 mice: Unraveling its triple anti-apoptotic, anti-inflammatory and anti-oxidant action". Biomedicine & Pharmacotherapy (2025): https://doi.org/10.1016/j.biopha.2025.118167. 10.1016/j.biopha.2025.118167 Mariana P. Sousa; Ana Cláudia Pereira; Bárbara Correia; Anália do Carmo; Ana Miguel Matos; Maria Teresa Cruz; Felismina T. C. Moreira. "Cellulose-Based Colorimetric Test Strips for SARS-CoV-2 Antibody Detection". Biosensors (2025): https://doi.org/10.3390/bios15060390. 10.3390/bios15060390 Mota, Sandra; Torres, Ana; Silva, Paulo; Silva, Joana Rocha e; Almeida, Agostinho; Páscoa, Ricardo N. M. J.; Ferreira, Helena N.; et al. "Overcoming challenges in the development of cosmetic formulations with agro-industrial by-products: The case of cork powder". International Journal of Cosmetic Science (2025): https://doi.org/10.1111/ics.13066. Published • 10.1111/ics.13066 Ana Jesus; Smeera Ratanji; Honorina Cidade; Emília Sousa; Maria T. Cruz; Rita Oliveira; Isabel F. Almeida. "Phenolics as Active Ingredients in Skincare Products: A Myth or Reality?". Molecules (2025): https://doi.org/10.3390/molecules30071423. 10.3390/molecules30071423 Sandra Mota; Liliana Rego; Emília Sousa; Maria Teresa Cruz; Isabel Martins de Almeida. "Usage Frequency and Ecotoxicity of Skin Depigmenting Agents". Pharmaceuticals (2025): https://doi.org/10.3390/ph18030368. 10.3390/ph18030368 Rodrigues, Beatriz; Ventura, Eduarda; Moreira, Patrícia; Resende, Rosa; Bicker, Joana; Santos, Armanda E.; Pereira, Cláudia Fragão; et al. "New low-dose curcumin derivative with therapeutic potential in Alzheimer’s disease: Results from an in vitro and in vivo study in mice". Neurobiology of Aging 147 (2025): 105-123. https://doi.org/10.1016/j.neurobiolaging.2024.12.005. Published • 10.1016/j.neurobiolaging.2024.12.005 Sebastião, Ana Isabel; Simões, Gonçalo; Oliveira, Filomena; Mateus, Daniela; Falcão, Amílcar; Carrascal, Mylène A.; Gomes, Célia; Neves, Bruno; Cruz, Maria Teresa. "Dendritic cells in triple-negative breast cancer: From pathophysiology to therapeutic applications". Cancer Treatment Reviews 133 (2025): 102884. https://doi.org/10.1016/j.ctrv.2025.102884. 10.1016/j.ctrv.2025.102884 Ana Silva; Cláudia Pinto; Sara M. Cravo; Sandra Mota; Liliana Rego; Smeera Ratanji; Clara Quintas; et al. "Sustainable Skincare Innovation: Cork Powder Extracts as Active Ingredients for Skin Aging". Pharmaceuticals (2025): https://www.mdpi.com/1424-8247/18/1/121. 10.3390/ph18010121 Silva, Ana; Silva, Sónia; Rodrigues, Beatriz; Simões, Gonçalo; Dinis, Inês; Freitas, Mafalda; Resende, Rosa; et al. "Targeting NRF2 With Isoeugenol: A Promising Small Molecule for Neurodegenerative, Metabolic, and Chronic Inflammatory Disorders". Oxidative Medicine and Cellular Longevity 2025 1 (2025): https://doi.org/10.1155/omcl/7695056. 10.1155/omcl/7695056 Moreira, Patrícia; Macedo, Jéssica; Matos, Patrícia; Bicker, Joana; Fortuna, Ana; Figueirinha, Artur; Salgueiro, Lígia; et al. "Effect of bioactive extracts from Eucalyptus globulus leaves in experimental models of Alzheimer’s disease". Biomedicine & Pharmacotherapy 181 (2024): 117652. http://dx.doi.org/10.1016/j.biopha.2024.117652. Published • 10.1016/j.biopha.2024.117652 Ana Jesus; Sara F. Vieira; Brites, G; Mylène Carrascal; Helena Ferreira; Nuno M. Neves; Honorina Cidade; et al. "1,2-Dihydroxy-<i>9H</i>-Xanthen-9-One, a Multifunctional Nature-Inspired Active Ingredient". Cosmetics (2024): https://www.mdpi.com/2079-9284/11/6/215. 10.3390/cosmetics11060215 Mariana Colaço; Maria T. Cruz; Luís Pereira de Almeida; Olga Borges. "Mannose and Lactobionic Acid in Nasal Vaccination: Enhancing Antigen Delivery via C-Type Lectin Receptors". Pharmaceutics (2024): https://doi.org/10.3390/pharmaceutics16101308. 10.3390/pharmaceutics16101308 Ana Jesus; Marta Correia-da-Silva; Catarina Confraria; Sílvia Silva; Brites, G; Ana Isabel Sebastião; Mylène Carrascal; et al. "Persulfated Ascorbic Acid Glycoside as a Safe and Stable Derivative of Ascorbic Acid for Skin Care Application". Molecules (2024): https://www.mdpi.com/1420-3049/29/19/4604. 10.3390/molecules29194604 Jorge M. Alves-Silva; Sónia Pedreiro; Mónica Zuzarte; Maria Teresa Cruz; Artur Figueirinha; Lígia Salgueiro. "Unlocking the Bioactive Potential and Exploring Novel Applications for Portuguese Endemic Santolina impressa". Plants (2024): https://doi.org/10.3390/plants13141943. 10.3390/plants13141943 Arregi, Ane; Vegas, Oscar; Lertxundi, Aitana; Silva, Ana Cristina Rosa da; Ferreira, Isabel; Bereziartua, Ainhoa; Cruz, Maria Teresa; Lertxundi, Nerea. "Road traffic noise exposure and its impact on health: evidence from animal and human studies—chronic stress, inflammation, and oxidative stress as key components of the complex downstream pathway underlying noise-induced non-auditory health effects". Environmental Science and Pollution Research 31 34 (2024): 46820-46839. https://doi.org/10.1007/s11356-024-33973-9. Published • 10.1007/s11356-024-33973-9 Pereira, Márcia; Cruz, Maria Teresa; Fortuna, Ana; Bicker, Joana. "Restoring the epigenome in Alzheimer's disease: advancing HDAC inhibitors as therapeutic agents". Drug Discovery Today 29 7 (2024): 104052. https://doi.org/10.1016/j.drudis.2024.104052. 10.1016/j.drudis.2024.104052 Matos, Patrícia; Paranhos, António; Oliveiros, Bárbara; Cruz, Maria Teresa; Batista, Maria Teresa; Figueirinha, Artur. "Biological and phytochemical variation with pre- and post-harvest conditions for the Acanthus mollis L. leaf". Industrial Crops and Products 211 (2024): 118221. http://dx.doi.org/10.1016/j.indcrop.2024.118221. 10.1016/j.indcrop.2024.118221 Panão Costa, João; Jesus, Sandra; Colaço, Mariana; Lebre, Filipa; Mateus, Daniela; Sebastião, Ana Isabel; Cruz, Maria Teresa; Alfaro-Moreno, Ernesto; Borges, Olga. "Exploring the immunomodulatory properties of glucan particles in human primary cells". International Journal of Pharmaceutics 655 123996 (2024): https://www.sciencedirect.com/science/article/pii/S0378517324002308?via%3Dihub. Published Galrinho, Miguel; Silva, Lisete; Lopes, Guido R.; Bernardo A. C. Ferreira; Valente, Sara A.; Isabel Ferreira; Pinheiro, Benedita; et al. Corresponding author: Passos, Claudia P.. "The study of galactomannans with different molecular weights and their ability to form microparticles suitable for pulmonary delivery". Carbohydrate Polymers (2024): Under revision Pereira, Ana Catarina; Serrano-Cuñarro, Laura; Cruz, Maria Teresa; Cavadas, Cláudia; Pereira, Cláudia Maria Fragão. "The link between alterations in circadian rhythms and lipid metabolism in bipolar disorder: the lipid droplets hypothesis". Brazilian Journal of Psychiatry (2024): https://doi.org/10.47626/1516-4446-2024-3670. 10.47626/1516-4446-2024-3670 Sandra Mota; Gonçalo P. Rosa; Maria Carmo Barreto; Jorge Garrido; Emília Sousa; Maria T. Cruz; Isabel F. Almeida; Clara Quintas. "Comparative Studies on the Photoreactivity, Efficacy, and Safety of Depigmenting Agents". Pharmaceuticals (2023): https://doi.org/10.3390/ph17010055. 10.3390/ph17010055 Daniela Mateus; Ana I. Sebastião; Manuela F. Frasco; Mylène A. Carrascal; Amílcar Falcão; Célia M. Gomes; Bruno Neves; Maria G. F. Sales; Maria T. Cruz. "Artificial Dendritic Cells: A New Era of Promising Antitumor Immunotherapy". Small (2023): https://doi.org/10.1002/smll.202303940. 10.1002/smll.202303940 Clarissa Perez Faria; Maria de Fátima Matos Almeida Henriques de Macedo; Barbara Ferreira; Ágata Lourenço; Inês Guerra; Tânia Melo; Pedro Domingues; et al. "Lipidome of extracellular vesicles from Giardia lamblia". PLOS ONE (2023): https://doi.org/10.1371/journal.pone.0291292. 10.1371/journal.pone.0291292 Isabel Ferreira; Gonçalo Brites; Ana Silva; Francisco Caramelo; Bárbara Oliveiros; Bruno Miguel Neves; Maria Teresa Cruz. "Development of an in chemico high-throughput screening method for the identification of skin sensitization potential". Archives of Toxicology (2023): https://doi.org/10.1007/s00204-023-03550-z. 10.1007/s00204-023-03550-z Jorge Miguel Alves-Silva; Sónia Pedreiro; Cruz MT; Salgueiro L.; Artur Figueirinha. "Exploring the Traditional Uses of <i>Thymbra capitata</i> Infusion in Algarve (Portugal): Anti-Inflammatory, Wound Healing, and Anti-Aging". Pharmaceuticals (2023): https://www.mdpi.com/1424-8247/16/9/1202. 10.3390/ph16091202 Jorge M. Alves-Silva; Sónia Pedreiro; Carlos Cavaleiro; Maria Teresa Cruz; Artur Figueirinha; Lígia Salgueiro. "Effect of Thymbra capitata (L.) Cav. on Inflammation, Senescence and Cell Migration". Nutrients (2023): https://doi.org/10.3390/nu15081930. 10.3390/nu15081930 Ana Torres; Liliana Rego; Márcia S. Martins; Marta S. Ferreira; Maria T. Cruz; Emília Sousa; Isabel F. Almeida. "How to Promote Skin Repair? In-Depth Look at Pharmaceutical and Cosmetic Strategies". Pharmaceuticals (2023): https://doi.org/10.3390/ph16040573. 10.3390/ph16040573 Sara A. Valente; Guido R. Lopes; Isabel Ferreira; Miguel F. Galrinho; Margarida Almeida; Paula Ferreira; Maria T. Cruz; Manuel A. Coimbra; Cláudia P. Passos. "Polysaccharide-Based Carriers for Pulmonary Insulin Delivery: The Potential of Coffee as an Unconventional Source". Pharmaceutics (2023): https://doi.org/10.3390/pharmaceutics15041213. 10.3390/pharmaceutics15041213 Ana Jesus; Ana I. Sebastião; Gonçalo Brites; Marta Correia-da-Silva; Honorina Cidade; Maria T. Cruz; Emília Sousa; Isabel F. Almeida. "A Hydrophilic Sulfated Resveratrol Derivative for Topical Application: Sensitization and Anti-Allergic Potential". Molecules (2023): https://doi.org/10.3390/molecules28073158. 10.3390/molecules28073158 Cátia. S. D. Oliveira; Patrícia Moreira; Maria T. Cruz; Cláudia M. F. Pereira; Artur M. S. Silva; Sónia A. O. Santos; Armando J. D. Silvestre. "Exploiting the Integrated Valorization of Eucalyptus globulus Leaves: Chemical Composition and Biological Potential of the Lipophilic Fraction before and after Hydrodistillation". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24076226. 10.3390/ijms24076226 Jorge Miguel Alves-Silva; Delia Maccioni; Emma Cocco; Maria José Gonçalves; Silvia Porcedda; Alessandra Piras; Maria Teresa Cruz; Lígia Salgueiro; Andrea Maxia. "Advances in the Phytochemical Characterisation and Bioactivities of Salvia aurea L. Essential Oil". Plants (2023): https://doi.org/10.3390/plants12061247. 10.3390/plants12061247 Ana Isabel Sebastião; Daniela Mateus; Mylène A. Carrascal; Cátia Sousa; Luísa Cortes; Martin F. Bachmann; Anália do Carmo; et al. "CuMV VLPs Containing the RBM from SARS-CoV-2 Spike Protein Drive Dendritic Cell Activation and Th1 Polarization". Pharmaceutics (2023): https://doi.org/10.3390/pharmaceutics15030825. 10.3390/pharmaceutics15030825 Mariana Colaço; Tiago Roquito; João Panão Costa; Maria Teresa Cruz; Olga Borges. "The Effect of Curcumin-Loaded Glucan Nanoparticles on Immune Cells: Size as a Critical Quality Attribute". 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"Leishmania-infected MHC class II<sup>high</sup> dendritic cells polarize CD4<sup>+</sup> T cells toward a nonprotective T-bet<sup>+</sup> IFN-¿<sup>+</sup> IL-10<sup>+</sup> phenotype". Journal of Immunology 191 1 (2013): 262-273. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879675210&partnerID=MN8TOARS. 10.4049/jimmunol.1203518 Zuzarte, M.; Gonçalves, M.J.; Cavaleiro, C.; Cruz, M.T.; Benzarti, A.; Marongiu, B.; Maxia, A.; Piras, A.; Salgueiro, L.. "Antifungal and anti-inflammatory potential of Lavandula stoechas and Thymus herba-barona essential oils". Industrial Crops and Products 44 (2013): 97-103. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870480491&partnerID=MN8TOARS. 10.1016/j.indcrop.2012.11.002 Valente, J.; Zuzarte, M.; Liberal, J.; Gonçalves, M.J.; Lopes, M.C.; Cavaleiro, C.; Cruz, M.T.; Salgueiro, L.. "Margotia gummifera essential oil as a source of anti-inflammatory drugs". 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American Journal of Pathology 177 6 (2010): 2898-2911. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650195216&partnerID=MN8TOARS. 10.2353/ajpath.2010.100367 Da Silva, L.; Carvalho, E.; Cruz, M.T.. "Role of neuropeptides in skin inflammation and its involvement in diabetic wound healing". Expert Opinion on Biological Therapy 10 10 (2010): 1427-1439. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956664657&partnerID=MN8TOARS. 10.1517/14712598.2010.515207 Figueirinha, A.; Cruz, M.T.; Francisco, V.; Lopes, M.C.; Batista, M.T.. "Anti-inflammatory activity of cymbopogon citratus leaf infusion in lipopolysaccharide-stimulated dendritic cells: Contribution of the polyphenols". Journal of Medicinal Food 13 3 (2010): 681-690. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953730391&partnerID=MN8TOARS. 10.1089/jmf.2009.0115 Francisco, V.; Neves, B.M.; Cruz, M.T.; Gonçalo, M.; Figueiredo, A.; Duarte, C.B.; Lopes, M.C.. "Effect of lipopolysaccharide, skin sensitizers and irritants on thioredoxin-1 expression in dendritic cells: Relevance of different signalling pathways". Archives of Dermatological Research 302 4 (2010): 271-282. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952180893&partnerID=MN8TOARS. 10.1007/s00403-009-0993-z do Carmo, Analia; Patricio, Ines; Cruz, Maria T.; Carvalheiro, Helena; Oliveira, Catarina R.; Lopes, Maria C.; do Carmo A; et al. "CXCL12/CXCR4 promotes motility and proliferation of glioma cells". Cancer Biology & Therapy 9 1 (2010): 56-65. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000274578800011&KeyUID=WOS:000274578800011. 10.4161/cbt.9.1.10342 Francisco, V; Figueirinha, A.; Neves, B.; Garcia-Rodriguez, C.; Lopes, M.; Cruz, M.; Batista, M.. "Polyphenols from Cymbopogon citratus inhibit iNOS expression and NO production - a promising source of new anti-inflammatory drugs". Planta Medica (2010): https://publons.com/publon/21604165/. Cabral, C.; Francisco, V; Cruz, M.; Lopes, M.; Salgueiro, L.; Sales, F.; Batista, M.. "Potential antioxidant and anti-inflammatory properties in Teucrium salviastrum Schreb". Planta Medica (2010): https://publons.com/publon/7273471/. 10.1055/S-0030-1264535 Neves, B.M.; Cruz, M.T.; Francisco, V.; Garcia-Rodriguez, C.; Silvestre, R.; Cordeiro-da-Silva, A.; Dinis, A.M.; et al. "Differential roles of PI3-Kinase, MAPKs and NF-¿B on the manipulation of dendritic cell T<inf>h</inf>1/T<inf>h</inf>2 cytokine/chemokine polarizing profile". Molecular Immunology 46 13 (2009): 2481-2492. http://www.scopus.com/inward/record.url?eid=2-s2.0-67650397827&partnerID=MN8TOARS. 10.1016/j.molimm.2009.05.021 Francisco, V.; Cruz, T.; Figueirinha, A.; Neves, B.; Lopes, C.; Batista, T.. "Inhibition of LPS-induced nuclear factor NF-kappa B activation by Cymbopogon citratus leaves in macrophages: a strategy to develop new anti-inflammatory drugs". Planta Medica 75 9 (2009): 942-942. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000268806600239&KeyUID=WOS:000268806600239. Carmo, Analia; Carvalheiro, Helena; Cruz, Maria Teresa; Lopes, Maria Celeste. "CXCL12/CXCR4 MODULATES GLIOMA CELL SURVIVAL AND MOTILITY". Iubmb Life 61 3 (2009): 326-326. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000264089500174&KeyUID=WOS:000264089500174. Tavares, A.C.; Gonçalves, M.J.; Cavaleiro, C.; Cruz, M.T.; Lopes, M.C.; Canhoto, J.; Salgueiro, L.R.; et al. "Essential oil of Daucus carota subsp. halophilus: Composition, antifungal activity and cytotoxicity". Journal of Ethnopharmacology 119 1 (2008): 129-134. http://www.scopus.com/inward/record.url?eid=2-s2.0-49349115295&partnerID=MN8TOARS. 10.1016/j.jep.2008.06.012 Neves, B.M.; Cruz, M.T.; Francisco, V.; Gonçalo, M.; Figueiredo, A.; Duarte, C.B.; Lopes, M.C.; et al. "Differential modulation of CXCR4 and CD40 protein levels by skin sensitizers and irritants in the FSDC cell line". Toxicology Letters 177 1 (2008): 74-82. http://www.scopus.com/inward/record.url?eid=2-s2.0-39549123001&partnerID=MN8TOARS. 10.1016/j.toxlet.2007.12.006 Carmo, A.; Patrlcio, M. I.; Amaro, P.; Cruz, M. T.; Lopes, M. C.. "CXCR4 expression mediates the survival and proliferation of glioma cells". Ejc Supplements 6 9 (2008): 20-20. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000257919000078&KeyUID=WOS:000257919000078. 10.1016/s1359-6349(08)71252-7 Neves, B.; Cruz, M. T.; Goncalo, M.; Figueiredo, A.; Duarte, C. B.; Lopes, M. C.. "Differential CXCR4 expression induced by skin sensitizers or irritants in dendritic cell models". Journal of Investigative Dermatology 127 (2007): S5-S5. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000249933400026&KeyUID=WOS:000249933400026. Cruz, M.T.; Neves, B.M.; Gonçalo, M.; Figueiredo, A.; Duarte, C.B.; Lopes, M.C.. "Effect of skin sensitizers on inducible nitric oxide synthase expression and nitric oxide production in skin dendritic cells: Role of different immunosuppressive drugs". Immunopharmacology and Immunotoxicology 29 2 (2007): 225-241. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548553284&partnerID=MN8TOARS. 10.1080/08923970701512304 Cruz, M.T.; Gonçalo, M.; Paiva, A.; Morgado, J.M.; Figueiredo, A.; Duarte, C.B.; Lopes, M.C.. "Contact sensitizers downregulate the expression of the chemokine receptors CCR6 and CXCR4 in a skin dendritic cell line". Archives of Dermatological Research 297 1 (2005): 43-47. http://www.scopus.com/inward/record.url?eid=2-s2.0-25644435637&partnerID=MN8TOARS. 10.1007/s00403-005-0574-8 Cruz, M.T.; Gonçalo, M.; Figueiredo, A.; Carvalho, A.P.; Duarte, C.B.; Lopes, M.C.. "Contact sensitizer nickel sulfate activates the transcription factors NF-kB and AP-1 and increases the expression of nitric oxide synthase in a skin dendritic cell line". Experimental Dermatology 13 1 (2004): 18-26. http://www.scopus.com/inward/record.url?eid=2-s2.0-0842308107&partnerID=MN8TOARS. 10.1111/j.0906-6705.2004.00105.x Vital, Ana Luísa; Gonçalo, Margarida; Cruz, Maria Teresa; Figueiredo, Américo; Duarte, Carlos B.; Lopes, Maria Celeste; Vital, A.L.; et al. "The Sensitizers Nickel Sulfate and 2,4-dinitrofluorobenzene Increase CD40 and IL-12 Receptor Expression in a Fetal Skin Dendritic Cell Line". Bioscience Reports 24 3 (2004): 191-202. http://hdl.handle.net/10316/7941. 10.1007/s10540-005-2580-7 Cruz, Maria Teresa; Gonçalo, Margarida; Américo Figueiredo; Carvalho A. P.; Duarte, Carlos B.; Lopes, Maria Celeste. "The contact sensitizer Nickel sulphate activates the transcription factor NF-kB and AP-1 and induces the expression of nitric oxide in a skin dendritic cell line". Experimental Dermatol 13 (2004): 18-26. Published Vital, A. L.; Gonçalo, Margarida; Cruz, Maria Teresa; Figueiredo, Américo; Duarte, Carlos B.; Lopes, Maria Celeste. "The sensitizers nickel sulfate and 2,4-dinitrofluorobenzene induce the expression of CD40 and IL-12 receptor in a fetal skin dendritic cell line, whereas 2,4-dichloronitrobenzene has no effect.". Bioscience Reports 24 (2004): 191-202. Published Vital, A.L.; Gonçalo, M.; Cruz, M.T.; Figueiredo, A.; Duarte, C.B.; Lopes, M.C.. "Dexamethasone prevents granulocyte-macrophage colony-stimulating factor-induced nuclear factor-¿B activation, inducible nitric oxide synthase expression and nitric oxide production in a skin dendritic cell line". Mediators of Inflammation 12 2 (2003): 71-78. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038466135&partnerID=MN8TOARS. 10.1080/0962935031000097673 Cruz, Maria Teresa; Duarte, Carlos B.; Gonçalo, Margarida; Figueiredo, Américo; Carvalho, Arsélio P.; Lopes, Maria Celeste; Cruz, M. T.; et al. "The Sensitizer 2,4-Dinitrofluorobenzene Activates Caspase-3 and Induces Cell Death in a Skin Dendritic Cell Line". International Journal of Toxicology 22 1 (2003): 43-48. http://hdl.handle.net/10316/11811. 10.1080/10915810390181490 Cruz, Maria Teresa; Duarte, Carlos B.; Gonçalo, Margarida; Figueiredo, Américo; Carvalho A. P.; Lopes, Maria Celeste. "The sensitizer 2,4 dinitrofluorbenzene induces cell death in a skin dendritic cell line by activating caspase 3". International Journal of Toxicology 22 (2003): 43-48. Published Vital, A. L.; Gonçalo, Margarida; Cruz, Maria Teresa; Duarte, Carlos B.; Figueiredo, Américo; Carvalho A. P.; Lopes, Maria Celeste. "Dexamethasone prevents GM-CSF induced NF-kB activation, iNOS expression and NO production in a skin dendritic cell line". Mediators Inflammation 12 (2003): 71-78. Published Cruz MT; Duarte CB; Gonçalo M; Figueiredo A; Carvalho AP; Lopes MC; Cruz, M. T.; et al. "Differential activation of nuclear factor kappa B subunits in a skin dendritic cell line in response to the strong sensitizer 2,4-dinitrofluorobenzene.". Archives of Dermatological Research 294 9 (2002): 419-425. http://europepmc.org/abstract/med/12522580. 10.1007/s00403-002-0342-y Cruz, M.T.; Duarte, C.B.; Gonçalo, M.; Figueiredo, A.; Carvalho, A.P.; Lopes, M.C.. "Granulocyte-macrophage colony-stimulating factor activates the transcription of nuclear factor kappa B and induces the expression of nitric oxide synthase in a skin dendritic cell line". Immunology and Cell Biology 79 6 (2001): 590-596. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035176476&partnerID=MN8TOARS. 10.1046/j.1440-1711.2001.01041.x Cruz, Maria Teresa; Duarte, Carlos B.; Gonçalo, Margarida; Carvalho A. P.; Lopes, Maria Celeste; Cruz, M.T.; Duarte, C.B.; et al. "LPS induction of IkB-¿ degradation and iNOS expression in a skin dendritic cell line is prevented by the Janus Kinase 2 inhibitor, tyrphostin B42". Nitric Oxide: Biology and Chemistry 5 5 (2001): 53-61. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035708551&partnerID=MN8TOARS. Published • 10.1006/niox.2000.0320 Gomes, E. R.; Cruz, T.; Lopes, C. F.; Carvalho, A. P.; Duarte, C. B.; Gomes, E.R.; Lopes, C.F.; Carvalho, A.P.; Duarte, C.B.. "Photosensitization of lymphoblastoid cells with phthalocyanines at different saturating incubation times". Cell Biology and Toxicology 15 4 (1999): 249-260. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000084642800005&KeyUID=WOS:000084642800005. 10.1023/a:1007615813184 Cruz, M.T.; Duarte, C.B.; Gonçalo, M.; Carvalho, A.P.; Lopes, M.G.; Cruz, M. T.; Duarte, C. B.; et al. "Involvement of JAK2 and MAPK on type II nitric oxide synthase expression in skin-derived dendritic cells". American Journal of Physiology - Cell Physiology 277 6 46-6 (1999): C1050-C1057. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033373205&partnerID=MN8TOARS. 10.1152/AJPCELL.1999.277.6.C1050 Cruz, M.T.; Carmo, A.; Carvalho, A.P.; Lopes, M.C.. "Calcium-dependent nitric oxide synthase activity in rat thymocytes". Biochemical and Biophysical Research Communications 248 1 (1998): 98-103. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032499870&partnerID=MN8TOARS. 10.1006/bbrc.1998.8865 Mendes, AF; Wong, H; Caramona, MM; Carvalho, AP; Lopes, MC; Cruz, TF. "Inhibition of ROS production prevents IL-1ß-induced iNOS expression in articular chondrocytes". Naunyn-Schmiedeberg's Archives of Pharmacology (1998): https://publons.com/wos-op/publon/10621892/. Cruz, T.; Gaspar, R.; Donato, A.; Lopes, C.. "Interaction between polyalkylcyanoacrylate nanoparticles and peritoneal macrophages: MTT metabolism, NBT reduction, and NO production". Pharmaceutical Research 14 1 (1997): 73-79. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031042535&partnerID=MN8TOARS. 10.1023/A:1012059501947
Newspaper article	Resende, Rosa; Silva, Ana; Cláudia Maria Fragão Pereira (PhD); Moreira, Paula Isabel; Santos, Armanda E; Cruz, Maria Teresa; Fernandes, Tânia; et al. "Doenças neurodegenerativas: um quebra-cabeças com solução à vista", O Público, 2021 Cruz, Maria Teresa. "Portuguese Natural Mineral Waters: chemical signature and antimicrobial activity against skin pathogenic and commensal microorganisms", 2020
Preprint	Clarissa Pérez Faria; Sandra Jesus; Ágata Lourenço; Bárbara Ferreira; Ana Isabel; Daniela Mateus; Bruno Neves; et al. "Unraveling the potential of Giardia extracellular vesicles as a vaccine candidat". 2024. https://doi.org/10.20944/preprints202403.0845.v1. 10.20944/preprints202403.0845.v1 Jorge M. Alves-Silva; Patrícia Moreira; Carlos Cavaleiro; Cláudia Pereira; Maria Teresa Cruz; Lígia Salgueiro. "Effect of Ferulago lutea (Poir.) Grande Essential Oil on Molecular Hallmarks of Skin Aging". 2023. https://doi.org/10.20944/preprints202310.1432.v1. 10.20944/preprints202310.1432.v1 Silva, Ana; Silva, Sónia; Macedo, Jéssica; Moreira, Patrícia; Baptista, Diana; Bicker, Joana; Fortuna, Ana; et al. "Targeting Alzheimer's disease hallmarks with the Nrf2 activator Isoeugenol". 2023. http://dx.doi.org/10.32388/luxm7w. 10.32388/luxm7w
Thesis / Dissertation	Oliveira, Constança Pinto Cruz Bonito de. "Internship and Monograph reports entitled”Exosomes as new therapeutic vectors for pancreatic cancer treatment"". Master, 2020. http://hdl.handle.net/10316/93113. Sebastião, Ana Isabel Madaleno. "Internship and Monograph reports entitled “NLRP3 Inflammasome and Allergic Contact Dermatitis: A Connection to Demystify”.". Master, 2020. http://hdl.handle.net/10316/93094. Marques, Sara Gabriela Costa. "Relatórios de Estágio e Monografia intitulada “Fumarato de Dimetilo, da Esclerose Múltipla às doenças Neurodegenerativas”". Master, 2020. http://hdl.handle.net/10316/93027. Portugal, Ricardo Antunes. "Dados do mundo real relativos ao tratamento com pembrolizumab de doentes com cancro do pulmão de células não-pequenas em estadio avançado previamente tratados.". Master, 2020. http://hdl.handle.net/10316/92926. Pereira, Marta Sofia Rosendo. "Skin allergens: Molecules with an improbable therapeutic application for Alzheimer's disease". Master, 2019. http://hdl.handle.net/10316/89648. Silva, Filipa Alexandra Lopes Simões da. "Sensibilizadores cutâneos: novas abordagens para previsão de toxicidade e gestão do risco". Master, 2019. http://hdl.handle.net/10316/88098. Mateus, Daniela Marques. "Relatório de Estágio e Monografia intitulada "Células T CAR - Uma nova estratégia imunoterapêutica".". Master, 2019. http://hdl.handle.net/10316/88339. Oliveira, Joana Margarida Monteiro. "Relatórios de Estágio e Monografia intitulada “Envolvimento da inflamação na doença bipolar: identificação de novos alvos terapêuticos”". Master, 2019. http://hdl.handle.net/10316/88293. Silva, Inês Filipa Cruz Soares. "To explore the use of a BH3-mimetic (ABT-737) as a chemosensitizer of osteosarcoma cells to doxorubicin.". Master, 2019. http://hdl.handle.net/10316/88347. Ribeiro, Inez Quaresma. "Estratégias Imunoterapêuticas aplicadas à Doença de Parkinson". Master, 2018. http://hdl.handle.net/10316/84495. Alves, Joana Filipa Catarino. "Chemo-enzymatic synthesis of new flavonoid derivatives with anti-inflammatory activity". Master, 2018. http://hdl.handle.net/10316/84606. Nogueira, João Filipe Duarte. "Relatórios de Estágio e Monografia intitulada “Inflamassomas – da Investigação à Terapêutica”". Master, 2017. http://hdl.handle.net/10316/83634. Turé, Jorge. "Relatório de estágio em Farmácia Comunitária e Monografia intitulada: "PLANTAS MEDICINAIS UTILIZADAS NA GUINÉ BISSAU PARA O TRATAMENTO DA MALÁRIA"". Master, 2017. http://hdl.handle.net/10316/83637. Branco, Tiago Miguel Dinis Prata. "Relatórios de Estágio e Monografia intitulada “Autofagia e Inflamassoma - Crosstalk e Relevância Fisiopatológica no Cancro”". Master, 2017. http://hdl.handle.net/10316/83709. Barbosa, Josiane Magalhães. "Preparação e avaliação da atividade anti-inflamatória de novos derivados polifenólicos glicosilados". Master, 2016. http://hdl.handle.net/10316/36550. Liberal, Joana Manuela Torres. "Fragaria vesca leaf as a source of bioactive phytochemicals - a focus on ellagitannins and their human microflora metabolites". PhD, 2016. http://hdl.handle.net/10316/30182. Carvalho, Amadeu Manuel Rodrigues. "O papel do farmacêutico na dispensa de suplementos alimentares e dispositivos médicos na farmácia comunitária em Portugal e no Brasil". Master, 2016. http://hdl.handle.net/10316/42832. Évora, Leisa Nélida Pinto. "Actividades biológicas e citotoxidade do óleo essencial de Rosmarinus officinalis L.". Master, 2015. http://hdl.handle.net/10316/30998. Catarino, Marcelo Dias. "Phenolic characterization and evaluation of the antioxidant and anti-inflammatory properties of Eriocephalus africanus and Geranium robertianum extracts". Master, 2015. http://hdl.handle.net/10316/31068. Lourenço, Ana Rita Pinho. "Fisiopatologia e farmacoterapia da asma". Master, 2015. http://hdl.handle.net/10316/88861. Jorge, Maria Inês Lourenço. "Relatório de estágio em farmácia hospitalar". Master, 2015. http://hdl.handle.net/10316/88975. Rodrigues, Vanessa Raquel Fonseca. "Avaliação da atividade anti-inflamatória do óleo essencial de Thymus zygis subsp. sylvestris e dos seus compostos principais". Master, 2014. http://hdl.handle.net/10316/30177. Tellechea, Ana Luísa Alves. "Cellular and molecular mechanisms of impaired wound healing in diabetes : understanding the role of substance P and mast cells". PhD, 2014. http://hdl.handle.net/10316/26466. Correia, Marlise Barbosa. "Vacinas baseadas em células dendríticas na esclerose múltipla". Master, 2014. http://hdl.handle.net/10316/89341. Santinha, Deolinda da Conceição Ribafeita. "Changes in lipidomic profile induced by lipopolysaccharide and skin sensitizer in dendritic cells and keratinocytes". Master, 2011. http://hdl.handle.net/10316/31379. Silva, Lucília Pereira. "Neurotensin effect on skin dendritic cells and fibroblasts: repercussions in wound healing and diabetic wound healing". Master, 2010. http://hdl.handle.net/10316/28818. Marques, Diane Raphaela. "Avaliação de perfil lipídico de células dendríticas imaturas e maduras". Master, 2010. http://hdl.handle.net/10773/3147. Rosete, Maria Teresa de Teixeira Cruz. "Vias de sinalização intracelular envolvidas na expressão da isoforma indutível da sintase do No : efeito do lipopolissacarídeo, citocinas e alergénios em células dentríticas da pele". PhD, 2004. http://hdl.handle.net/10316/532.

Intellectual property

Patent

2022. "SMALL MOLECULES FOR USE IN PREVENTING AND/OR TREATMENT OF NEURODEGENERATIVE DISEASES". Portugal.
Pending
Cruz, Maria Teresa; Neves, Bruno; Rosa, Susana; Amílcar Falcão; João D. Martins; Isabel Cristina Ferreira; Joana Filipa Sousa; Ana Cristina Rosa da Silva. 2016. "Method for Determining Low Molecular Weight Respiratory Allergens (Provisional Patent Application no201510000228)". Portugal.
Granted/Issued
Cruz, Maria Teresa. 2015. "Cork hydroglycolic extract, method for preparing same, formulations comprising said extract and use thereof".
Pending
Cruz, Maria Teresa. 2012. "Development of a dendritic cell-derived in vitro test to detect skin sensitizers".
Expired

Provisional application for patent

2015. "AN IN SILICO AND IN VITRO INTEGRATIVE APPROACH TO ASSESS THE POTENCY OF CONTACT ALLERGENS".
2015. "METHOD FOR DETERMINING LOW MOLECULAR WEIGHT RESPIRATORY ALLERGENS".
Protected
2014. "AN IN SILICO AND IN VITRO INTEGRATIVE APPROACH TO ASSESS THE POTENCY OF CONTACT ALLERGENS".
2014. "METHOD FOR DETERMINING LOW MOLECULAR WEIGHT RESPIRATORY ALLERGENS".
2014. "FUNCTIONALIZED MATRICES TO DETECT THE HAPTENIZATION CAPACITY OF XENOBIOTICS".
Protected
2013. "A QUANTITATIVE APPROACH TO ASSESS THE POTENCY OF CONTACT ALLERGENS".
Protected
2011. "AN IN VITRO CELL-BASED TEST FOR SKIN SENSITIZATION PREDICTION".

Other

Other output

Imunoterapia baseada em células dendríticas no cancro pancreático. Monografia realizada no âmbito da unidade de Estágio Curricular do Mestrado Integrado em Ciências Farmacêuticas, apresentada à Faculdade de Farmácia da Universidade de Coimbra. cancro pancreático (PC) representa um dos tumores sólidos mais agressivos e devastadores, caracterizado por apresentar uma elevada incidência e um mau prognóstico. As estratégias terapêuticas atuais são, muitas vezes, insat. 2016. Rosete, Maria Teresa Teixeira Cruz. http://hdl.handle.net/10316/43064.
Alzheimer e vacinas terapêuticas. Monografia realizada no âmbito da unidade de Estágio Curricular do Mestrado Integrado em Ciências Farmacêuticas, apresentada à Faculdade de Farmácia da Universidade de Coimbra. A doença de Alzheimer (AD) é uma doença progressiva, multifatorial e complexa, em que a fisiopatologia antecede cerca de 10 a 20 anos o aparecimento de sintomas clínicos. Ao longo dos anos, a patogénese da AD tem sido assoc. 2016. Rosete, Maria Teresa Teixeira Cruz. http://hdl.handle.net/10316/43062.
Exosomes in Alzheimer's disease: potential biomarkers for pre-clinical diagnosis and their therapeutic role. Monografia realizada no âmbito da unidade de Estágio Curricular do Mestrado Integrado em Ciências Farmacêuticas, apresentada à Faculdade de Farmácia da Universidade de Coimbra. Alzheimer disease (AD) is chronic, progressive, increasingly prevalent and has a long asymptomatic latency period. Current diagnosis of AD consists mainly in imaging techniques and measurement of bioindicators in the bodily. 2016. Rosete, Maria Teresa Teixeira Cruz. http://hdl.handle.net/10316/48528.
Suplementos alimentares e dispositivos médicos na prevenção e tratamento de cististes recorrentes na mulher. Monografia realizada no âmbito da unidade de Estágio Curricular do Mestrado Integrado em Ciências Farmacêuticas, apresentada à Faculdade de Farmácia da Universidade de Coimbra. Os suplementos alimentares e dispositivos médicos estão disponíveis nas farmácias comunitárias e constituem um instrumento relevante para um melhor aconselhamento farmacêutico. O aumento da comercialização e introdução dest. 2015. Rosete, Maria Teresa Teixeira Cruz. http://hdl.handle.net/10316/79834.
O envolvimento das células dendríticas no lúpus eritematoso sistémico. Monografia realizada no âmbito da unidade de Estágio Curricular do Mestrado Integrado em Ciências Farmacêuticas, apresentada à Faculdade de Farmácia da Universidade de Coimbra. O Lúpus Eritematoso Sistémico (LES) resulta de um funcionamento incorreto do sistema imunitário, afetando preferencialmente mulheres na sua idade fértil. O desenvolvimento desta patologia é modulado por fatores genéticos, h. 2015. Rosete, Maria Teresa. http://hdl.handle.net/10316/81309.
Imunoterapia com células dendríticas: uma promessa para terapia de cancro. Monografia realizada no âmbito da unidade de Estágio Curricular do Mestrado Integrado em Ciências Farmacêuticas, apresentada à Faculdade de Farmácia da Universidade de Coimbra. As células dendríticas (DCs) são consideradas o centro do sistema imunitário, dado que estabelecem a ligação entre a imunidade inata e adaptativa, apresentando capacidade de controlo não só da reposta imune, mas também da t. 2014. Rosete, Maria Teresa Teixeira Cruz. http://hdl.handle.net/10316/79621.
Associação de vacinas baseadas em células dendríticas com quimioterapia : uma nova estratégia terapêutica contra o cancro. Monografia realizada no âmbito da unidade de Estágio Curricular do Mestrado Integrado em Ciências Farmacêuticas, apresentada à Faculdade de Farmácia da Universidade de Coimbra. As células dendríticas são consideradas as células apresentadoras de antigénios mais potentes e desempenham um papel crucial na programação e regulação de respostas imunes específicas antitumorais. Devido às suas caracterís. 2014. Rosete, Maria Teresa Teixeira Cruz. http://hdl.handle.net/10316/80528.

Spin-off company

2012. Toxfinder Lda. Previsão Toxicológica. http://toxfinder.pt/pt-pt/.

Activities

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2020 - Current	Circadian rhythm disruption in Bipolar disorder: from molecular mechanisms to novel therapeutic targets Supervisor of Ana Catarina de Jesus Pais Pereira
2018 - Current	Development of a Medical Device for prevention of Allergic Contact Dermatitis Supervisor of Gonçalo Sousa Brites	Universidade de Coimbra Faculdade de Farmácia, Portugal
2018 - Current	Characterization of phytochemical components of Eucalyptus globulus leaves and their pharmacological potentials: a multi-functional insight. Supervisor	Universidade de Coimbra Faculdade de Farmácia, Portugal
2017 - Current	Desenvolvimento de plataformas baseadas em células dendriticas para screening toxicológico e farmacológico Supervisor of João Miguel Calmeiro	Universidade de Coimbra Faculdade de Farmácia, Portugal
2015 - Current	Desenvolvimento de uma plataforma in-vitro/in chemico para a identificação de alergénios respiratórios Supervisor of Isabel Ferreira	Universidade de Coimbra Faculdade de Farmácia, Portugal
2010 - Current	In vitro cellular approach for skin sensitization hazard: an EU legislation demand Supervisor of Joao Demetrio Goncalves Boto Martins	Universidade de Coimbra Faculdade de Farmácia, Portugal
2010 - Current	Discovery of new anti-inflammatory drugs from natural products through bio-guided assays Supervisor	Universidade de Coimbra Faculdade de Farmácia, Portugal
2010 - Current	Discovery of new anti-inflammatory and anti-fungal drugs from esential oils Supervisor
2019/07 - 2020/07	Immunotherapy for pancreatic and lung cancer: Potentiation of antigen cross-presentation in dendritic-cell based vaccines. Supervisor	Universidade de Coimbra Faculdade de Farmácia, Portugal
2019/07 - 2020/07	Avaliação do efeito dos regimes clássicos de quimioterapia e imunoterapia no perfil metabolómico de linhas celulares de cancro de pulmão de não pequenas células Supervisor	Universidade de Coimbra Faculdade de Farmácia, Portugal
2019 - 2020/07	Dados do mundo real do tratamento com pembrolizumab de doentes com cancro com pulmão de células não-pequenas em estadio avançado previamente tratados Supervisor	Universidade de Coimbra Faculdade de Farmácia, Portugal
2018/07 - 2020/07	Pesquisa de novos Biomarcadores para o Carcinoma de células renais claras Supervisor	Universidade de Coimbra Faculdade de Farmácia, Portugal
2018/07 - 2019/07	Skin allergens: molecules with an improbable therapeutic application for Alzheimer’s disease Supervisor	Universidade de Coimbra Faculdade de Medicina, Portugal
2018/07 - 2019	Skin sensitizers: moving forward new approaches for toxicity prevision and sensitization management” Supervisor	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017/07 - 2018/07	Chemo-enzymatic synthesis of new flavonoid derivatives with anti-inflammatory activity Supervisor
2015 - 2016	O papel do farmacêutico na dispensa de suplementos alimentares e dispositivos médicos na farmácia comunitária em Portugal e no Brasil Supervisor
2015/07 - 2015/07	Preparação e avaliação da actividade anti-inflamatória de novos derivados polifenólicos glicosilados Supervisor	Universidade de Coimbra Faculdade de Farmácia, Portugal
2014/07 - 2015/07	THE ROLE OF CARDIOMYOCYTES-DERIVED EXOSOMES IN MACROPHAGE ACTIVATION AND POLARIZATION Supervisor	Universidade de Coimbra Faculdade de Medicina, Portugal
2014/07 - 2015/07	Bioactivity of essential oils obtained from Rosmarinus officinalis L. Supervisor	Universidade de Coimbra Faculdade de Farmácia, Portugal
2014 - 2015	Evaluation of the antioxidant and anti-inflammatory properties of Eriocephalus africanus extracts Supervisor	Universidade de Coimbra Faculdade de Farmácia, Portugal
2013 - 2014	Avaliação da atividade anti-inflamatória do óleo essencial de Thymus zygis subsp. sylvestris e dos seus compostos principais Supervisor	Universidade de Coimbra Faculdade de Farmácia, Portugal
2012/09 - 2013/09	Evaluation of ER stress induced by DNFB in dendritic cells Supervisor	Universidade de Aveiro, Portugal
2012 - 2013	AUTOPHAGY AND INFLAMMSOME: HOW ARE THEY RELATED? Supervisor	Universidade de Coimbra Faculdade de Medicina, Portugal
2009 - 2013	Anti-inflammatory mechanism and properties of plants used in traditional medicine: evaluation of their potential use as source for new anti-inflammatory drugs Supervisor	Universidade de Coimbra Faculdade de Farmácia, Portugal
2009 - 2013	Molecular Mechanisms of Wound Healing Supervisor	Universidade de Coimbra Faculdade de Farmácia, Portugal
2010/09 - 2011/09	Efeito de alergénios cutâneos no perfil lipídico de células dendríticas e queratinócitos Supervisor	Universidade de Coimbra Faculdade de Medicina, Portugal
2010 - 2011	Alergias do Tracto Respiratório Rinite Alérgica/Asma Supervisor	Universidade de Coimbra Faculdade de Farmácia, Portugal
2010 - 2011	Reações de hipersensibilidade do aparelho respiratório Supervisor	Universidade de Coimbra Faculdade de Farmácia, Portugal
2010 - 2011	Diagnóstico e Tratamento das Doenças da Próstata Supervisor	Universidade de Coimbra Faculdade de Farmácia, Portugal
2007 - 2011	Identification of cellular and molecular markers selectively activated by skin sensitizers in dendritic cells Supervisor of Bruno Miguel Neves	Universidade de Coimbra Faculdade de Farmácia, Portugal
2009/07 - 2010/07	Neuropeptides and skin inflammation Supervisor
2009/07 - 2010	Profiling changes triggered during dendritic cells maturation: a lipidomic approach Supervisor	Universidade de Aveiro, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2020/02/05 - 2020/02/07	Membro da Comissão Organizadora e Científica da 50.ª Reunião da Sociedade Portuguesa de Farmacologia, 38.ª Reunião de Farmacologia Clínica e 19.ª Reunião de Toxicologia, que decorreu na FFUC (2020/02/05) Congress
2019 - 2019	Co-organization of the advanced course Neurodegenerative Disorders, Program in Experimental Biology and Biomedicine (BEB), CNC (2019)
2008 - 2008	Co-organization of two advanced courses in Immunology, Ph.D. Program in Experimental Biology and Biomedicine (BEB), CNC (2008)
2006 - 2006	Co-organization of one advanced course in Neuroimmunology, Ph.D. Program in Experimental Biology and Biomedicine (BEB), CNC (2006)

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2020	Metabolic networks and metabolism in acute myeloid leucemia	Olga Marisa da Silva Pereira (PhD) Universidade do Minho, Portugal
2019	DESENVOLVIMENTO DE METODOLOGIAS PARA O ESTUDO DA INFLUÊNCIA DA OXIDAÇÃO DE AMINOFOSOFOLIPIDOS NA RESPOSTA IMUNE	Simone Colombo (PhD) Universidade de Aveiro, Portugal
2018	High value-added products from macroalgae: lipids as bioactive compounds	Elisabete Valente da Costa (PhD)
2017	Preclinical performance of vaginal semisolid products: technological and safety evaluations assuming physiologic parameters	Rita Solange Machado (PhD) Universidade da Beira Interior, Portugal
2017	Towards an Efficient Filtration and Characterization of Airborne Nanoparticles	Rita Joana Vaz dos Santos (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017	Analytical Strategies based on mass spectrometry toward identifying nitro oxidative modifications in phospholipids	Tânia Sofia Rodrigues de Melo (PhD) Universidade de Aveiro, Portugal
2016	FRAGARIA VESCA LEAF AS A SOURCE OF BIOACTIVE PHYTOCHEMICALS - A FOCUS ON ELLAGITANNINS AND THEIR HUMAN MICROFLORA METABOLITES	Joana Manuela Torres Liberal (PhD) Universidade de Coimbra Faculdade de Farmácia, Portugal
2015	Adjuvant nanocarriers for hepatitis B vaccine: formulation design and mechanistic studies	Sandra Cristina de Jesus (PhD) Universidade de Coimbra Faculdade de Farmácia, Portugal
2014	Structural Characterization and Biological Activity of Polysaccharides from infusions used in popular tradition	Vitor Manuel Ramalheira Martins (PhD) Universidade de Aveiro, Portugal
2014	Oxidação e glicoxidação da fosfatidilserina e os seus efeitos na resposta imune: uma abordagem lipidómica	Maria Elisabete Maciel (PhD) Universidade de Aveiro, Portugal
2014	Glucose sensing and modulation of human chondrocyte functions by hyperglycemia: relevance as pharmacological targets for diabetes-associated OA	Ana Teresa Rufino (PhD) Universidade de Coimbra Faculdade de Farmácia, Portugal
2014	Cellular and molecular mechanisms of impaired wound healing in diabetes: understanding the role of substance P and mast cells	Ana Luísa Tellechea (PhD) Universidade de Coimbra Faculdade de Farmácia, Portugal
2013	Efeito da própolis e de compostos isolados sobre a expressão de receptores, produção de citocinas e atividade fungicida de monócitos humanos	Michelle Cristiane Bufalo (PhD) Universidade Estadual Paulista Júlio de Mesquita Filho - Câmpus de Botucatu, Brazil
2013	Geoprópolis de Melipona fasciculata Smith: ações citotóxica, imunomoduladora, antibacteriana e antifúngica	Maria José Abigail Mendes Araújo (PhD) Universidade Estadual Paulista Júlio de Mesquita Filho - Câmpus de Botucatu, Brazil
2013	Drug Discovery of new anti-inflammatory phytochemicals using in vitro bio-guided assays: the case study of Cymbopogun citratus	Vera Lúcia Francisco (PhD) Universidade de Coimbra Faculdade de Farmácia, Portugal
2012	Portuguese Lavanders: evaluation of their potential use for health and agricultural purposes	Mónica da Rocha Zuzarte (PhD) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012	Genetic imbalances and numerical chromossomal alterations in glioblastomas as assessed by single-nucleotide polymorphism (SNP)-arrays and their impacto n gene expression	Ana Inês Rebelo Crespo (PhD) Universidade de Coimbra Faculdade de Farmácia, Portugal
2011	Intratumoral Genetic Heterogeneity of Gliomas as assessed by combined interphase FISH and cDNA micro-arrays: impact on the clinical and biological behavior of the disease	Ana Luísa Vital Castanheira de Carvalho (PhD) Universidade de Coimbra Faculdade de Farmácia, Portugal
2011	CYMBOPOGON CITRATUS COMPOSIÇÃO FENÓLICA E ACTIVIDADE ANTI-INFLAMATÓRIA	Artur Manuel Machado Figueirinha (PhD) Universidade de Coimbra Faculdade de Farmácia, Portugal
2011	Identification of cellular and molecular markers selectively activated by skin sensitizers in dendritic cells	Bruno Miguel Neves (PhD) Universidade de Coimbra Faculdade de Farmácia, Portugal
2011	Alergias do Tracto Respiratório Rinite Alérgica/Asma	Lara Sofia Bolota Fonseca Alves Correia Machado (Master) Universidade de Coimbra Faculdade de Farmácia, Portugal
2011	Reações de hipersensibilidade do aparelho respiratório	Maria Luísa Pinto Ferreira (Master) Universidade de Coimbra Faculdade de Farmácia, Portugal
2010	Condrócitos	Susana Carvalho Rosa (PhD) Universidade de Coimbra Faculdade de Farmácia, Portugal
2010	Avaliação do perfil lipídico de células dendríticas imaturas e maduras	Diana Marques (Master) Universidade de Aveiro, Portugal
2010	Neuropeptides and skin inflammation	Lucília Santos (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2010	Thymbra Capitata (L.) Cav. Waste Materials as a Resource of Bioactive Polyphenols	Marta Geraldes Dias (Master) Universidade de Coimbra Faculdade de Farmácia, Portugal
2010	Profiling changes triggered during dendritic cells maturation: a lipidomic approach	Diana Raphaela Marques (Master) Universidade de Aveiro, Portugal
2010	Neuropeptides and skin inflammation	Lucília Santos (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009	Modulation of dendritic cells function by Leishmania excreted/secreted antigens (Thesis) Arguer	Mariana Resende (Master) Universidade do Porto, Portugal
2009	Screening e identificação de inibidores naturais da produção de NO e da activação do NF-kB, induzidas pela Interleucina-1beta,em condrócitos humanos (Thesis) Arguer	Ângela Neves (Master) Universidade de Coimbra Faculdade de Farmácia, Portugal
2008	Neuropeptídeo Y e os seus receptores na retina: da proliferação Celular à Neuroprotecção	Ana Rita da Costa e Silva Álvaro (PhD) Universidade de Coimbra Faculdade de Farmácia, Portugal
2007	Alterações induzidas pelo sensibilizador químico DNFB em células dendríticas da pele: regulação das MAPK, da libertação de IL-1¿ e de receptores membranares	Maria Teresa de Jesus Matos (PhD)

Association member

	Society Organization name	Role
2020/02/04 - Current	Sociedade Portuguesa de Imunologia
2017/04/06 - Current	European Registered Toxicologist
2015/06/03 - Current	Associação Portuguesa de Toxicologia (APTox)
2014/03/06 - Current	Sociedade Portuguesa de Farmacologia
1992/02/06 - Current	Ordem dos Farmacêuticos

Committee member

	Activity description Role	Institution / Organization
2020/03/06 - Current	Involvement in the adaptation of a Biosafety level 3 laboratory at the University of Coimbra for the diagnostic of the novel coronavirus, SARS-Coronavirus-2 (SARS-CoV-2), which is currently performing about 400 tests per day. Coordinator	Universidade de Coimbra, Portugal
2020/01/02 - Current	2ª vogal do Conselho de Administração da Associação UC Tecnimede Member	Universidade de Coimbra, Portugal

Evaluation committee

	Activity description Role	Institution / Organization
2017 - 2017	Member of the evaluation panel of scientific projects in the areas of Cellular and Molecular Biology and Immunology Evaluator	National Center of Science and Technology Evaluation Ministry of Education and Science Republic of Kazakhstan, Kazakhstan, Kazakhstan
2015 - 2015	Member of the evaluationpanel of scientific projects inthe areas of Cellular and Molecular Biology and Immunology Evaluator	National Center of Science and Technology Evaluation Ministry of Education and Science Republic of Kazakhstan, Kazakhstan, Kazakhstan
2013 - 2013	Avaliadora de bolsas FCT (doutoramento) Evaluator
2013 - 2013	Avaliadora de projetos no âmbito do concurso Arrisca Coimbra - Concurso de Planos de Negócio, DITS Evaluator

Journal scientific committee

	Journal title (ISSN)	Publisher
2018 - Current	Evidence-based Complementary and Alternative Medicine (1741-4288)	Hindawi Limited
2016/03/06 - Current	Scientific Reports (2045-2322)	Springer Science and Business Media LLC
2019 - 2019	Frontiers in Physiology (1664-042X)	Frontiers Media SA
2019 - 2019	Pharmaceutics (1999-4923)	MDPI AG

Legal proceeding

	Activity description	Case
2017/02/03 - Current	Establishement of the UC / Tecnimede Cell Therapy pilot laboratory. This pilot laboratory aims to provide the region center with infrastructures that will enable it to take the lead of Cellular Therapy in Portugal.	To obtain Good Manufacturing Practice ( GMP) for handling cellular products for clinical application

Mentoring / Tutoring

	Topic	Student name
2019 - Current	Allergens4AD-Skin allergens: molecules with an improbable therapeutic application for Alzheimer's disease	Ana Silva
2012 - Current	Electrophilic stress: molecular targets for skin sensitizers	Sofia Guedes

Distinctions

Award

2018	The best poster in basic research European Society of Contact Dermatitis, Germany

Other distinction

2018	Melhor trabalho apresentado na área de Investigação Básica, no décimo quarto Congresso da Sociedade Europeia de Dermatite de Contacto, realizado em Milão, Itália,
2018	ImmunoTools Special Award para o projeto de doutoramento do aluno João Calmeiro
2013	Prémio de inovação e empreendedorismo
2012	Regional Business Ideas Competition
2011	BOLSAS DE IGNIÇÃO para o projecto “Detecção do potencial sensibilizador cutâneo de químicos”.
2011	Idea to Product Fundación Cotec, Spain
2010	Prémio “Igualdade” - do Concurso de Ideias de Negócio Arrisca Coimbra '10 com o projecto “Teste in vitro para detecção do potencial alérgico cutâneo de químicos: uma imposição da nova legislação europeia” .
2008	Melhor poster na area de investigaçao basica e clinica
2008	“Prix de Recherche Sientific Lierac”
1993	Mellhor classificação na licenciaturado do Ramo A (Farmácia de Oficina e Hospitalar) Ordem dos Farmaceuticos, Portugal