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Marta Reina Couto. Concluiu o(a) Licenciatura em Medicina em 2007/07/01 pelo(a) Universidade do Porto Faculdade de Medicina. Frequenta o(a) Doutoramento em Farmacologia e Toxicologia Experimentais e Clínicas pelo(a) Universidade do Porto Faculdade de Medicina desde 2016/01. É Assistente no(a) Centro Hospitalar Universitário de São João, Membro da Direção do Colégio de Especialidade de Farmacologia Clínica no(a) Ordem dos Médicos e Assistente Convidado no(a) Universidade do Porto Faculdade de Medicina. Publicou 16 artigos em revistas especializadas. Possui 2 capítulo(s) de livros. Orientou 1 dissertação(ões) de mestrado e coorientou 10. Recebeu 5 prémio(s) e/ou homenagens. Participa e/ou participou como Investigador em 2 projeto(s) e Orientador em 1 projeto(s). Atua na(s) área(s) de Ciências Médicas e da Saúde com ênfase em Medicina Básica com ênfase em Farmacologia e Farmácia, Ciências Médicas e da Saúde com ênfase em Medicina Clínica com ênfase em Medicina dos Cuidados Intensivos e Medicina de Urgência, Ciências Médicas e da Saúde com ênfase em Medicina Clínica com ênfase em Sistemas Cardíacos e Cardiovasculares, Ciências Médicas e da Saúde com ênfase em Medicina Clínica com ênfase em Medicina Geral e Medicina Interna e Ciências Médicas e da Saúde com ênfase em Medicina Clínica com ênfase em Outras Áreas da Medicina Clínica. No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: inflamação; resolução da inflamação; stresse oxidativo; insuficiência cardíaca; COVID-19; disfunção endotelial; sistema renina-angiotensina-aldosterona; Chronic heart failure; renin-angiotensin-aldosterone system; cardiorenal syndrome; oxidative stress; inflammation; acute heart failure; cardiogenic shock; mechanical circulatory life support; clinical trials; pharmacovigilance; therapeutic drug monitoring; Resolution of inflammation; endothelial dysfunction; arterial hypertension; pharmacology; .
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Identification

Personal identification

Full name
Marta Reina Couto

Citation names

  • Couto, Marta
  • Reina-Couto, M.
  • Couto, MR

Author identifiers

Ciência ID
6110-28F7-1E5D

Email addresses

  • martafrcouto@hotmail.com (Personal)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
  • Medical and Health Sciences - Clinical Medicine - Critical care Medicine and Emergency Medicine
  • Medical and Health Sciences - Clinical Medicine - Cardiac and Cardiovascular Systems
  • Medical and Health Sciences - Clinical Medicine - General and Internal Medicine
  • Medical and Health Sciences - Clinical Medicine - Other Clinical Medicine Subjects

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
French Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2)
German Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2022/05 - 2025
Ongoing
 Grau de Consultor da Especialidade de Medicina Interna (Título de especialista)
Hospital São Pedro de Vila Real, Portugal
2023/01 - 2023/06
Attended
 Economia da Saúde e Resultados em Saúde (Pós-Graduação)
Universidade Nova de Lisboa Escola Nacional de Saúde Pública, Portugal
2016/01 - 2022
Ongoing
 Farmacologia e Toxicologia Experimentais e Clínicas (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2018 - 2021
Concluded
 Medicina Intensiva (Título de especialista)
Centro Hospitalar Universitário de São João, Portugal
2017 - 2017
Concluded
 Farmacologia Clínica (Título de especialista)
Universidade do Porto Faculdade de Medicina, Portugal
2015 - 2015
Concluded
 Farmacologia e Toxicologia Experimentais e Clínicas (Curso de doutoramento (conclusão de unidades curriculares))
Universidade do Porto Faculdade de Medicina, Portugal
 17,5
2009/01/01 - 2013/12/31
Concluded
 Medicina Interna (Título de especialista)
Centro Hospitalar Universitário de São João Serviço Medicina Interna, Portugal
 19,9
2008/01 - 2008/12
Concluded
 Internato do Ano Comum (Especialização pós-licenciatura)
Major in Formação generalista de Medicina
Centro Hospitalar Universitário de São João, Portugal
 Aprovado
1999/09/01 - 2007/07/01
Concluded
 Medicina (Licenciatura)
Universidade do Porto Faculdade de Medicina, Portugal
 16
Affiliation

Science

Category
Host institution 		Employer
2005/03 - 2015 Researcher (Research) Universidade do Porto Faculdade de Medicina, Portugal
Universidade do Porto Faculdade de Medicina, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2010/09 - Current Invited Assistant (University Teacher) Universidade do Porto Faculdade de Medicina, Portugal
Universidade do Porto Faculdade de Medicina, Portugal

Other Careers

Category
Host institution 		Employer
2014 - Current Assistente (Médica) Centro Hospitalar Universitário de São João, Portugal
Centro Hospitalar Universitário de São João, Portugal
2008/01 - 2013/12 Interno (Médica) Centro Hospitalar Universitário de São João Serviço Medicina Interna, Portugal
Centro Hospitalar Universitário de São João Serviço Medicina Interna, Portugal

Positions / Appointments

Category
Host institution 		Employer
2020 - 2024 Membro da Direção do Colégio de Especialidade de Farmacologia Clínica Ordem dos Médicos, Portugal

Others

Category
Host institution 		Employer
2023 - Current Membro da Comissão de Farmácia e Terapêutica Unidade Local de Saúde São João, Portugal
Projects

Contract

Designation Funders
2018/07 - Current Resolution of inflammation: a missing key to improve acute heart failure treatment and prognosis?
PTDC/MEC-CAR/32188/2017
POCI-01-0145-FEDER- 032188
Researcher
Universidade do Porto Faculdade de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2020/07 - 2021/07 Unresolved inflammation and endothelitis in severe COVID-19 patients: identification of risk stratification biomarkers and therapeutic targets
613690173
Researcher
Universidade do Porto Faculdade de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2009 - 2010 Evaluation of intrarenal renin-angiotensin system activation and oxidative stress in chronic heart failure.
PP-IJUP2009-119
Supervisor
Universidade do Porto Faculdade de Medicina, Portugal
 Banco Santander Portugal
Concluded
Outputs

Publications

Book chapter
  1. Sousa, Teresa; Reina-Couto, Marta; Gomes, Pedro. "Role of Oxidative Stress in the Pathophysiology of Arterial Hypertension and Heart Failure". In Oxidative Stress in Heart Diseases, 509-537. Springer Singapore, 2019.
    Published • 10.1007/978-981-13-8273-4_23
  2. Morato, Manuela; Reina-Couto, Marta; Pinho, Dora; Albino-Teixeira, António; Sousa, Teresa. "Regulation of the Renin-Angiotensin-Aldosterone System by Reactive Oxygen Species". In Renin-Angiotensin System - Past, Present and Future, 119-157. InTech, 2017.
    Published • 10.5772/67016
Conference abstract
  1. Reina-Couto, M.; Silva-Pereira, Carolina; Pereira-Terra, Patricia; Quelhas-Santos Janete; Bessa, João; Marques, Catarina; Serrão, Paula; et al. ""Endocan - a potential new biomarker of inflammation-driven endothelitis in human acute heart failure and cardiogenic shock.". Rev. Port. Cardiol. 40 Espec Cong (2021): 75-76.". Paper presented in Congresso Português de Cardiologia 2021 - Virtual, 2021, 2021.
    Published
  2. Moura, Ana Rita; Reina-Couto, M.; Roncon-Albuquerque Jr, Roberto; Paiva, José Artur. "Patients admitted with Acute Heart Failure at an Intensive Care Medicine Department of a tertiary care Hospital - characterization of patients submitted to mechanical circulatory support - Rev. Port. Cardiol. 40 Espec Cong (2021): 74-75.". Paper presented in Congresso Português de Cardiologia 2021 - Virtual, 2021, 2021.
    Published
  3. Moura, Ana Rita; Reina-Couto, M.; Roncon-Albuquerque Jr, Roberto; Paiva, José Artur. "Clinical predictors of in-hospital mortality in patients admitted with acute heart failure in an intensive care department. Rev Port Cardiol. 2021; 39(Espec. Congr.):98". Paper presented in Congresso Português de Cardiologia 2021 - Virtual, 2021, 2021.
    Published
  4. Reina-Couto, M.; Pereira-Terra, Patrícia; Silva-Pereira, Carolina; Quelhas-Santos Janete; Serrão, Paula; Afonso Joana; Sandra Martins; et al. "Venoarterial extracorporeal membrane oxygenation appears to induce higher neutrophil-derived inflammation and oxidative stress at the end of the first week of hospitalization. Intensive Care Med Exp 2021, 9(Suppl 1):51 [001064]". Paper presented in 34th Annual Congress of the European Society of Intensive Care Medicine - ESICM Lives 2021, Digital, 2021, 2021.
    Published • https://doi.org/10.1186/s40635-021-00413-8
  5. ""Proinflammatory cytokines and endothelial cell activation in human acute heart failure versus septic shock.". Intensive Care Medicine Experimental 8 2 (2020): 001521.". Paper presented in 33rd Annual Congress - ESICM LIVES DIGITAL 2020, 2020, 2020.
    Published • https://doi.org/10.1186/s40635-020-00354-8.
  6. Moura, Ana Rita; Reina-Couto, M.; Roncon-Albuquerque Jr, Roberto; Paiva, José Artur. "Profile of hospitalized patients with heart failure admitted in an intensive care department of a tertiary care hospital. Rev. Port. Cardiol. 2020;39(Espec. Congr):200". Paper presented in Congresso Português de cardiologia 2020, 2020.
    Published
  7. Silva-Pereira, Carolina; Reina-Couto, M.; Quelhas-Santos Janete; Sousa-Oliveira, Ana; Duarte, Álvaro; Pinho, Dora; Serrão, Paula; et al. ""Lipoxin profiles in human acute heart failure and cardiogenic shock and their modulation by aspirin or statin therapy. European Journal of Clinical Investigation 50 Suppl 1 (2020): 43.". Paper presented in ESCI Virtual Meeting 2020 | COVID19 edition, 2020, 2020.
    Published • Clinical Investigation 50 Suppl 1 (2020): 43. http://doi.org/10.1111/eci.13369.
  8. Reina-Couto, M.; Silva-Pereira, Carolina; Quelhas-Santos Janete; Pinho, Dora; Martins, Sandra; Serrão, Paula; Afonso, Joana; et al. ""Proinflammatory cytokines and endothelial cell activation in human acute heart failure and cardiogenic shock.". European Journal of Clinical Investigation 50 Suppl 1 (2020): 44-45.". Paper presented in ESCI Virtual Meeting 2020 | COVID19 edition, 2020, 2020.
    Published • http://doi.org/10.1111/eci.13369.
  9. Reina-Couto, M.; Silva-Pereira, Carolina; Bessa, João; Oliveira-Santos, Marisa; Serrão, Paula; Afonso, Joana; Roncon-Albuquerque Jr, Roberto; et al. ""Inflammation and resolution of inflammation in human acute heart failure.". Intensive Care Medicine Experimental 7 3 (2019): 001499.". Paper presented in ESICM LIVES 2019, Berlin, 2019, Berlin, 2019.
    Published • https://doi.org/10.1186/s40635-019-0265-y.
  10. Reina-Couto, M.; Bessa, João; Oliveira-Santos, Marisa; Serrão, Paula; Afonso, Joana; Roncon-Albuquerque Jr, Roberto; Paiva, José Artur; Sousa, Teresa; Albino-Teixeira, António. ""Resolvins in human acute heart failure.". European Journal of Clinical Investigation 49 1 (2019): 204-205". Paper presented in 53rd Annual Meeting of the European Society for Clinical Investigation (ESCI), Coimbra, 2019.
    Published • http://dx.doi.org/10.1111/eci.13109.
  11. Reina-Couto, M.; Bessa, João; Oliveira-Santos, Marisa; Serrão, Paula; Afonso, Joana; Roncon-Albuquerque Jr, Roberto; Paiva, José Artur; Albino-Teixeira, António; Sousa, Teresa. ""Endocan and resolvin-D1 association with ventricular dysfunction, lactic acidosis and prognostic scores in human acute heart failure.". European Journal of Heart Failure 21 S1 (2019): 114 [P476].". Paper presented in Heart Failure 2019 - European Society of Cardiology, Atenas, 2019.
    Published • https://doi.org/10.1002/ejhf.1488.
  12. Reina-Couto, M.; Cruz, Rita; Serrão, Paula; Afonso, Joana; Roncon-Albuquerque Jr, Roberto; Paiva, José Artur; Albino-Teixeira, António; Morato, M; Sousa, Teresa. "Angiotensinogen and Hydrogen peroxide in human acute heart failure. Rev Port Cardiol. 2019; 38 (Espec. Congr): 140-141". Paper presented in Congresso Português de cardiologia 2019, Algarve, 2019.
    Published
  13. Reina-Couto, M.; Bessa, João; Serrão, Paula; Afonso, Joana; Roncon-Albuquerque Jr, Roberto; Paiva, José Artur; Albino-Teixeira, António; Sousa, Teresa. ""Endocan and resolvin D1: two novel biomarkers for the management of acute heart failure?". Intensive Care Medicine Experimental 6 2 (2018): 1001.". Paper presented in 31st Annual Congress - ESICM, Paris, Paris, 2018.
    Published • https://doi.org/10.1186/s40635-018-0201-6
  14. Reina-Couto, M.; Bessa, João; Serrão, Paula; Afonso, Joana; Roncon-Albuquerque Jr, Roberto; Paiva, José Artur; Albino-Teixeira, António; Sousa, Teresa. ""Inflammation resolution mediators in acute heart failure.". Journal of Hypertension 36 e-Suppl 1 (2018): e211.". Paper presented in 28th European Meeting on Hypertension and Cardiovascular Protection, Barcelona, 2018.
    Published • https://insights.ovid.com/crossref?an=00004872-201806001-00642.
  15. Reina-Couto, M.; Bessa, João; Serrão, Paula; Afonso, Joana; Roncon-Albuquerque Jr, Roberto; Paiva, José Artur; Albino-Teixeira, António; Sousa, Teresa. ""Endocan as a new biomarker of severity in acute heart failure.". European Journal of Heart Failure 20 Suppl 1 (2018): 113.". Paper presented in Heart Failure 2018 and the World Congress on Acute Heart Failure, 26–29 May 2018, Vienna, Austria, Vienna, 2018.
    Published • https://doi.org/10.1002/ejhf.1197
  16. Reina-Couto, M.; Sousa, Teresa; Morato, M; Afonso, Joana; Carvalho, Jorge; Fernandes, FB; Leite, VP; et al. ""Interrelationship between renin-angiotensin-aldosterone system and oxidative stress in chronic heart failure patients with impaired renal function.". European Journal of Heart Failure 19 Suppl 1 (2017): 570". Paper presented in Heart Failure 2017 and the 4th World Congress on Acute Heart Failure, Paris, 2017.
    Published • 10.1002/ejhf.833
  17. Marta, Reina-Couto; Sousa, Teresa; M. Morato; Carvalho, Jorge; Afonso, Joana; Bettencourt, P.; Albino-Teixeira, António. ""Higher urinary hydrogen peroxide levels are associated with increased plasma renin activity and aldosterone concentration in patients with chronic heart failure.". European Journal of Heart Failure 18 Suppl 1 (2016): 495.". Paper presented in Heart Failure 2016 Conference and the 3rd World Congress on Acute Heart Failure, Florence, 2016.
    Published • https://doi.org/10.1002/ejhf.539
  18. M. Morato; Reina-Couto, M.; Morgado, Luís; Afonso, Joana; Fernandes, FB; Leite, VP; Belo, Luis; et al. "Impact of renin-angiotensin system (RAS) blockade in RAS components in patients with Chronic Heart Failure. Journal of Hypertension, vol 32, e-Sup 1, 2014, e535; PP32.25". 2014.
    Published
  19. Reina-Couto, M.; Morato, M; Morgado, Luís; Afonso, Joana; Sousa, Teresa; Bettencourt, P.; Albino-Teixeira, António. "Effect of renin-angiotensin blockade treatment in angiotensinogen levels in patients with chronic heart failure. European Journal of Heart Failure (2014), 16 (supply. 2), 68, P332.". Paper presented in Heart Failure Congress 2014 and the 1st World Congress on Acute Heart Failure, Atenas, 2014.
    Published
Conference poster
  1. Reina-Couto, M.; Silva-Pereira, Carolina; Pereira-Terra, Patricia; Sousa, Teresa; Albino-Teixeira, António. "Increased urinary isoprostanes are associated with severity and mortality in COVID-19 patients". Paper presented in 8th European Virtual Congress of Pharmacology (EPHAR 2021), 2021, 2021.
  2. Reina-Couto, M.; Silva-Pereira, Carolina; Pereira-Terra, Patricia; Sousa, Teresa; Albino-Teixeira, António. "Angiotensin converting enzyme 2 (ACE2) activity in COVID-19 patients: a study throughout hospitalization in different stages of disease severity". Paper presented in 8th European Virtual Congress of Pharmacology (EPHAR 2021), 2021, 2021.
Journal article
  1. Reina-Couto, Marta; Alves, David; Silva-Pereira, Carolina; Pereira-Terra, Patrícia; Martins, Sandra; Bessa, João; Teixeira-Santos, Luísa; et al. "Endocan as a marker of endotheliitis in COVID-19 patients: modulation by veno-venous extracorporeal membrane oxygenation, arterial hypertension and previous treatment with renin–angiotensin–aldosterone system inhibitors". Inflammation Research 74 1 (2025): https://doi.org/10.1007/s00011-024-01964-8.
    10.1007/s00011-024-01964-8
  2. Borges-Carneiro, Filipa; Torre Souto, Miguel; Silva, Isabel; Leão Moreira, Paula; Ferraz de Oliveira, Paula; Lopes, Diogo José; Figueira, Luís; et al. "Clinical Trials in Portugal: Past and Future. Position Paper from the Colleges of Clinical Pharmacology and Pharmaceutical Medicine". Acta Médica Portuguesa 37 9 (2024): 585-588. https://doi.org/10.20344/amp.21371.
    10.20344/amp.21371
  3. Reina-Couto, Marta; Roboredo-Madeira, Mariana; Pereira-Terra, Patrícia; Silva-Pereira, Carolina; Martins, Sandra; Teixeira-Santos, Luísa; Pinho, Dora; et al. "Evaluation of urinary cysteinyl leukotrienes as biomarkers of severity and putative therapeutic targets in COVID-19 patients". Inflammation Research 72 3 (2023): 475-491. http://dx.doi.org/10.1007/s00011-022-01682-z.
    10.1007/s00011-022-01682-z
  4. Reina-Couto, Marta; Santos-Oliveira, Marisa; Pereira-Terra, Patrícia; Silva-Pereira, Carolina; Quelhas-Santos, Janete; Duarte, Álvaro; Martins, Sandra; et al. "Urinary Cysteinyl Leukotrienes as Biomarkers of Endothelial Activation, Inflammation and Oxidative Stress and Their Relationship with Organ Dysfunction in Human Septic Shock". Biomedicines 10 11 (2022): 2845. http://dx.doi.org/10.3390/biomedicines10112845.
    10.3390/biomedicines10112845
  5. Reina-Couto, Marta; Silva-Pereira, Carolina; Pereira-Terra, Patrícia; Quelhas-Santos, Janete; Bessa, João; Serrão, Paula; Afonso, Joana; et al. "Endothelitis profile in acute heart failure and cardiogenic shock patients: Endocan as a potential novel biomarker and putative therapeutic target". Frontiers in Physiology 13 (2022): http://dx.doi.org/10.3389/fphys.2022.965611.
    10.3389/fphys.2022.965611
  6. Reina-Couto, Marta; Pereira-Terra, Patrícia; Quelhas-Santos, Janete; Silva-Pereira, Carolina; Albino-Teixeira, António; Sousa, Teresa. "Inflammation in Human Heart Failure: Major Mediators and Therapeutic Targets". Frontiers in Physiology 12 (2021): http://dx.doi.org/10.3389/fphys.2021.746494.
    Published • 10.3389/fphys.2021.746494
  7. Reina-Couto, Marta; Afonso, Joana; Carvalho, Jorge; Morgado, Luís; Ronchi, Fernanda Aparecida; de Oliveira Leite, Ana Paula; Dias, Cláudia Camila; et al. "Interrelationship between renin-angiotensin-aldosterone system and oxidative stress in chronic heart failure patients with or without renal impairment". Biomedicine & Pharmacotherapy 133 (2021): 110938. http://dx.doi.org/10.1016/j.biopha.2020.110938.
    Published • 10.1016/j.biopha.2020.110938
  8. Bessa, João; Albino-Teixeira, António; Reina-Couto, Marta; Sousa, Teresa. "Endocan: A novel biomarker for risk stratification, prognosis and therapeutic monitoring in human cardiovascular and renal diseases". Clinica Chimica Acta 509 (2020): 310-335. http://dx.doi.org/10.1016/j.cca.2020.07.041.
    Published • 10.1016/j.cca.2020.07.041
  9. Dias, Andreia M.; Cordeiro, Gonçalo; Estevinho, Maria M.; Veiga, Rui; Figueira, Luis; Reina-Couto, Marta; Magro, Fernando. "Gut bacterial microbiome composition and statin intake—A systematic review". Pharmacology Research & Perspectives 8 3 (2020): http://dx.doi.org/10.1002/prp2.601.
    Published • 10.1002/prp2.601
  10. Soares, Neuza; Dias, Emanuel; Formigo, Mariana; Torres-Ramalho, P.; Braz, Luis; Marta, Reina-Couto. "Anti-N-Methyl-D-Aspartate Receptor Encephalitis with Concomitant Detection of <i>Epstein-Barr</i> Virus". Neuroscience and Medicine 10 03 (2019): 194-198. http://dx.doi.org/10.4236/nm.2019.103013.
    Published • 10.4236/nm.2019.103013
  11. Adlbrecht, Christopher; Blanco-Verea, Alejandro; Bouzas-Mosquera, María C.; Brion, María; Burtscher, Martin; Carbone, Federico; Chang, Ting-Ting; et al. "Research update for articles published in EJCI in 2016". European Journal of Clinical Investigation 48 10 (2018): e13016. http://dx.doi.org/10.1111/eci.13016.
    Published • 10.1111/eci.13016
  12. Costa, Ana Catarina; Reina-Couto, Marta; Albino-Teixeira, António; Sousa, Teresa. "Aspirin and blood pressure: Effects when used alone or in combination with antihypertensive drugs". Revista Portuguesa de Cardiologia 36 7-8 (2017): 551-567. http://dx.doi.org/10.1016/j.repc.2017.05.008.
    Published • 10.1016/j.repc.2017.05.008
  13. Agra, Rosa María; Al-Daghri, Nasser M.; Badimon, Lina; Bodi, Vicente; Carbone, Federico; Chen, Mao; Cubedo, Judit; et al. "Research update for articles published in EJCI in 2014". European Journal of Clinical Investigation 46 10 (2016): 880-894. http://dx.doi.org/10.1111/eci.12671.
    Published • 10.1111/eci.12671
  14. Reina-Couto, Marta; Vale, Luís; Carvalho, Jorge; Bettencourt, Paulo; Albino-Teixeira, António; Sousa, Teresa. "Resolving Inflammation in Heart Failure: Novel Protective Lipid Mediators". Current Drug Targets 17 10 (2016): 1206-1223. http://dx.doi.org/10.2174/1389450117666160101121135.
    Published • 10.2174/1389450117666160101121135
  15. Costa, Sónia; Reina-Couto, Marta; Albino-Teixeira, António; Sousa, Teresa. "Estatinas e stresse oxidativo na insuficiência cardíaca crónica". Revista Portuguesa de Cardiologia 35 1 (2016): 41-57. http://dx.doi.org/10.1016/j.repc.2015.09.006.
    Published • 10.1016/j.repc.2015.09.006
  16. Alvelos, Margarida; Couto, Marta; Laszczynska, Olga; Almeida, Pedro B.; Guimarães, João; Azevedo, Ana; Bettencourt, Paulo. "Measuring renal function in acute heart failure: A place for old and new equations". International Journal of Cardiology 196 (2015): 70-72. http://dx.doi.org/10.1016/j.ijcard.2015.05.171.
    Published • 10.1016/j.ijcard.2015.05.171
  17. Pimentel, Rodrigo; Couto, Marta; Laszczynska, Olga; Friões, Fernando; Bettencourt, Paulo; Azevedo, Ana. "Prognostic value of worsening renal function in outpatients with chronic heart failure". European Journal of Internal Medicine 25 7 (2014): 662-668. http://dx.doi.org/10.1016/j.ejim.2014.06.002.
    Published • 10.1016/j.ejim.2014.06.002
  18. Lourenço, Patrícia; Silva, Sérgio; Friões, Fernando; Alvelos, Margarida; Amorim, Marta; Couto, Marta; Torres-Ramalho, Paulo; et al. "Low prealbumin is strongly associated with adverse outcome in heart failure". Heart 100 22 (2014): 1780-1785. http://dx.doi.org/10.1136/heartjnl-2014-305747.
    Published • 10.1136/heartjnl-2014-305747
  19. Reina-Couto, Marta; Carvalho, Jorge; Valente, Maria João; Vale, Luís; Afonso, Joana; Carvalho, Félix; Bettencourt, Paulo; Sousa, Teresa; Albino-Teixeira, António. "Impaired resolution of inflammation in human chronic heart failure". European Journal of Clinical Investigation 44 6 (2014): 527-538. http://dx.doi.org/10.1111/eci.12265.
    Published • 10.1111/eci.12265
  20. Cunha, F. M.; Lourenco, P.; Couto, M.; Tavares, P.; Silva, S.; Guimaraes, T.; Bettencourt, P.. "Is the blood pressure paradox observed in all heart failure patients?". European Heart Journal 34 suppl 1 (2013): P2728-P2728. http://dx.doi.org/10.1093/eurheartj/eht309.p2728.
    Published • 10.1093/eurheartj/eht309.p2728
  21. Pinho, Dora; Morato, Manuela; Couto, Marta R.; Marques-Lopes, José; Tavares, Isaura; Albino-Teixeira, António. "Does Chronic Pain Alter the Normal Interaction Between Cardiovascular and Pain Regulatory Systems? Pain Modulation in the Hypertensive-Monoarthritic Rat". The Journal of Pain 12 2 (2011): 194-204. http://dx.doi.org/10.1016/j.jpain.2010.06.009.
    Published • 10.1016/j.jpain.2010.06.009
Newsletter article
  1. Reina-Couto, M.; Vale, Luís; Carvalho, Jorge; Sousa, Teresa; Bettencourt, P.; Albino-Teixeira, António. ""Resolution of inflammation: The missing key to improve heart failure prognosis?"", EurekAlert! , 2016, https://www.eurekalert. org/pub_releases/2016-09/bsp-roi090516.php., 2016, https://www.eurekalert. org/pub_releases/2016-09/bsp-roi090516.php..
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022 ACE2/ACE balance in COVID-19 patients with different disease severity. LII Reunião da Sociedade Portuguesa de Farmacologia (SPF 2022)
(Porto, Portugal)
2022 Inflammatory cytokine response in moderate and severe COVID-19 patients and its relationship to prognosis. LII Reunião da Sociedade Portuguesa de Farmacologia (SPF 2022)
(Porto, Portugal)
2022 Arachidonic acid derived proresolving or proinflammatory mediators and lipoxin receptor expression in human acute heart failure and cardiogenic shock LII Reunião da Sociedade Portuguesa de Farmacologia (SPF 2022)
(Porto, Portugal)
2022 Impact of previous ß-blocker treatment on inflammatory status of acute heart failure and cardiogenic shock patients. LII Reunião da Sociedade Portuguesa de Farmacologia (SPF 2022)
(Porto, Portugal)
2021 Comparison of endothelial activation profiles in critically ill patients with cardiogenic shock, septic shock and severe COVID-19. 8th European Virtual Congress of Pharmacology (EPHAR 2021), 2021
(Czech Republic)
2021 Inflammatory and resolution of inflammation responses in critically ill patients with cardiogenic shock, septic shock and severe COVID-19. 8th European Virtual Congress of Pharmacology (EPHAR 2021), 2021
(Czech Republic)
2021 Evaluation of serum and urinary lipoxin profiles and FPR2/ALX receptor expression in human acute heart failure, cardiogenic shock and septic shock. 8th European Virtual Congress of Pharmacology (EPHAR 2021), 2021
(Czech Republic)
2021 Urinary biomarkers of oxidative stress, inflammation and vascular dysfunction in septic shock patients and their relationship with organ dysfunction and prognosis. LI Reunião da Sociedade Portuguesa de Farmacologia
Universidade de Lisboa Faculdade de Farmácia (Lisboa, Portugal)
2021 Endothelial cell activation and proinflammatory status decrease during hospitalization in septic shock but not in cardiogenic shock. LI Reunião da Sociedade Portuguesa de Farmacologia
Universidade de Lisboa Faculdade de Farmácia (Lisboa, Portugal)
2021 Resolution of inflammation in human acute heart failure and cardiogenic shock: role of resolvin D1 and E1. LI Reunião da Sociedade Portuguesa de Farmacologia
Universidade de Lisboa Faculdade de Farmácia (Lisboa, Portugal)
2020 Lipoxin profiles in human acute heart failure and cardiogenic shock and their modulation by aspirin or statin therapy. ESCI Virtual - COVID Edition 2020
2020 Proinflammatory cytokines and endothelial cell activation in human acute heart failure and cardiogenic shock. ESCI Virtual - COVID Edition 2020
2020 Serum and urinary lipoxins profiles in patients with acute heart failure and cardiogenic shock. L Reunião da Sociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2020 Comparison of the inflammatory profile in patients with cardiogenic shock or septic shock. L Reunião da Sociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal) (Coimbra, Portugal)
2019 Endocan, a novel endothelial dysfunction biomarker, is associated with ventricular dysfunction, inflammation and worse hemodynamics in human acute heart failure. YES Meeting 2019
Universidade do Porto Faculdade de Medicina (Porto, Portugal) (Porto, Portugal)
2019 Endothelial dysfunction and inflammation resolving mediators in human acute heart failure. XLIX Reunião da Sociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia (Porto, Portugal) (Porto, Portugal)
2019 Specialized proresolving mediators (SPMs) in human acute heart failure (AHF). 1a Reunião do Programa Doutoral em Farmacologia e Toxicologia Experimental e Clínica
Universidade do Porto Faculdade de Medicina (Porto, Portugal) (Porto, Portugal)
2018 Endocan and resolvin D1: two novel biomarkers for the management of acute heart failure? 31st Annual Congress of the European Society of Intensive Care Medicine – ESICM LIVES 2018
European Society of Intensive Care Medicine (Paris, France)
2013 Anti-inflammatory lipoxins in patients with chronic heart failure and their modulation by low-dose acetylsalicylic acid. 47th Annual Scientific Meeting of the European Society for Clinical Investigation
European Society for Clinical Investigation (Albufeira, Portugal) (Albufeira, Portugal)
2013 Anti-inflammatory lipid mediators in cardiovascular diseases: impact of aspirin. Seminários FMUP
Universidade do Porto Faculdade de Medicina (Porto, Portugal) (Porto, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2021/09 - Current Evolution of endocan and other endothelial dysfunction markers in COVID-19 patients with different stages of disease severity.
Co-supervisor of David André Rosário Alves
 Medicina (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2021/09 - Current Evaluation of urinary cysteinyl leukotrienes as biomarkers of severity and putative therapeutic targets in COVID-19 patients.
Co-supervisor of Mariana Simões de Carvalho Roboredo Madeira
 Medicina (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2021/09 - Current Evaluation of urinary 11- dehydrothromboxane B2 as a biomarker of severity and putative therapeutic target in human acute heart failure.
Co-supervisor of Ana Isabel Sousa Oliveira
 Medicina (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2020/09 - 2021/06/22 Urinary cysteinyl leukotrienes as biomarkers of endothelial activation, inflammation and oxidative stress and their relationship with organ dysfunction in human septic shock.
Supervisor of Marisa Oliveira Santos
 Medicina (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2020/09 - 2021/05/28 Renal renin-angiotensin system activation in acute heart failure and its association with endothelial dysfunction, inflammation and oxidative stress.
Co-supervisor of Álvaro Alexandre Ferreira Duarte
 Medicina
Universidade do Porto Faculdade de Medicina, Portugal
2019/08 - 2020/08 Endocan: a novel biomarker for risk stratification, prognosis, and therapeutic monitoring in human cardiovascular and renal diseases.
Co-supervisor of João Pedro Peixoto de Bessa e Silva
 Medicina (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2016 - 2017 Aspirin and blood pressure: effects when used alone or in combination with antihypertensive drugs.
Co-supervisor of Ana Catarina Gonçalves da Costa
 Medicina (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2014 - 2015 Statins and oxidative stress in chronic heart failure.
Co-supervisor of Sónia Cristina Torres da Costa
 Medicina (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2013 - 2014 Resolution of inflammation in heart failure: novel lipid mediators.
Co-supervisor of Luís Manuel Pedrosa do Vale
 Medicina (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2011 - 2012 Evaluation of lipoxins in heart failure.
Co-supervisor
 Bioquímica (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2011 - 2012 Oxidative stress in heart failure: therapeutic implications.
Co-supervisor of Marco Frederico Oliveira Marques
 Medicina (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2011 - 2012 Renin-angiotensin-aldosterone system and oxidative stress in chronic heart failure patients
Co-supervisor
 Medicina (Master)
Universidade do Porto Faculdade de Medicina, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2019/12/05 Estrategias de tratamientodel paciente co insuficiencia cardiacasistólica agudamente descompensada: efectos de frecuentes doses de furosemide sobre los niveles serios de urea y cobre el cociente urea/creatinina
Thesis Member
 Rafael Ramion Villegas Mendez (Master)
Universidade do Porto Faculdade de Medicina, Portugal

Association member

Society Organization name Role
2018 - Current European Society of Intensive Care Medicine Membro
2012 - Current Sociedade Portuguesa de Farmacologia Efective member

Committee member

Activity description
Role 		Institution / Organization
2022 - Current Colégio de Medicina Intensiva
Member
 Ordem dos Médicos, Portugal
2020 - Current Membro da Direcção do Colégio de Farmacologia Clínica da Ordem dos Médicos
Other
 Ordem dos Médicos, Portugal
2014 - Current Colégio de Medicina Interna
Member
 Ordem dos Médicos, Portugal

Consulting

Activity description Institution / Organization
2021 - Current Membro da comissão de trabalho na DGS para norma terapêutica do tratamento da COVID-19 no âmbito de membro do Colégio de Farmacologia Clínica da Ordem dos Médicos Centro Hospitalar Universitário de São João, Portugal
2019 - Current Cerca de 50 pareceres/ano para Comissão de Farmácia e Terapêutica do CHUSJ no âmbito de membro da Unidade de Farmacologia Clínica Centro Hospitalar Universitário de São João, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2010 - Current Farmacologia Medicina (Mestrado integrado) Universidade do Porto Faculdade de Medicina, Portugal
2010 - Current Terapêutica Medicina (Mestrado integrado) Universidade do Porto Faculdade de Medicina, Portugal
Distinctions

Award

2024 Ambiotis poster prize
2020 ESCI Short Presentation Award - European Society of Clinical Investigation, Netherlands
European Society for Clinical Investigation, Netherlands
2019 3rd Prize - Oral Presentation - Plenary Session YES Meeting 2019
Universidade do Porto Faculdade de Medicina, Portugal
2013 Alberto Ferrari Poster Prize - European Society of Hypertension, Italy
2012 1st place poster prize National Congress of HIV
2010 3rd place in Hypertension Summer School