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Ana Rita Guimarães completed her PhD in Biomedicine at the University of Aveiro in 2023, specializing in the evolution of the genetic code and codon reassignment using Saccharomyces cerevisiae as a model organism. She has a strong foundation in Biology, holding a BSc and MSc in Molecular and Cellular Biology from the same university. Her early research, during a BSc internship at the Faculty of Medicine, University of Porto, focused on the cardiovascular effects of apelin in pulmonary hypertension models. For her MSc thesis, she joined the RNA Biology laboratory under Professor Manuel Santos, where she studied how codon ambiguities could lead to codon reassignment in S. cerevisiae. This research sparked her interest in genetic codes, leading to her involvement in projects on antifungal resistance and mistranslation in Candida albicans before her PhD. During her doctoral research, she became proficient in a range of laboratory techniques, including CRISPR cloning, experimental evolution, and mistranslation assessment using advanced reporters. She also developed extensive bioinformatics expertise, particularly in whole-genome and transcriptomic analysis. Currently, she is a researcher at iBiMED's Bioinformatics Lab, where she studies the genetic and epigenetic variome of clinical Candida albicans isolates. Her work focuses on analyzing large-scale sequencing data to identify genetic variants associated with fungal adaptation and virulence, supporting the project's aim to implement Personalized Medicine approaches for fungal infections. She also collaborates on multiple NGS-based projects, manages HPC resources and bioinformatics pipelines, and provides support to other researchers. She has shared her research at several national and international conferences, contributed to six publications, and is actively involved in science outreach activities such as the Junior/Summer Academy, Xperimenta UA, and educational sessions for secondary school students. Additionally, she leads an MSc course in Bioinformatics Data Analysis, where she teaches computational approaches for biological data interpretation.
Identification

Personal identification

Full name
Ana Rita Guimarães

Citation names

  • Guimarães, Ana R.

Author identifiers

Ciência ID
5F18-21A4-FEA9
ORCID iD
0000-0002-2202-3065

Email addresses

  • rita.guimaraes88@gmail.com (Professional)
  • rita.guimaraes@ua.pt (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences - Biology

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2017/09 - 2023/12/20
Concluded
Biomedicina (Doutoramento)
Universidade de Aveiro, Portugal
"Recoding the Saccharomyces cerevisiae genome" (THESIS/DISSERTATION)
2014
Concluded
Biologia Molecular e Celular (Mestrado)
Universidade de Aveiro, Portugal
"Codon ambiguities as a mechanism to alter the genetic code in S. cerevisiae" (THESIS/DISSERTATION)
17
2012
Concluded
Biologia (Licenciatura)
Universidade de Aveiro, Portugal
"n/a" (THESIS/DISSERTATION)
15,4
Affiliation

Science

Category
Host institution
Employer
2024/06/01 - Current Contracted Researcher (Research) Universidade de Aveiro Instituto de Biomedicina, Portugal
2016/05/01 - 2017/08/31 Researcher (Research) Universidade de Aveiro Instituto de Biomedicina, Portugal
2015/07/01 - 2016/04/30 Researcher (Research) Universidade de Aveiro Centro de Estudos do Ambiente e do Mar, Portugal

Others

Category
Host institution
Employer
2023/10/01 - 2024/01/31 Prestação de serviços Universidade de Aveiro, Portugal
2022/11/15 - 2023/06/30 Técnico superior Universidade de Aveiro, Portugal
2011/09/01 - 2012/07/30 Intern Universidade do Porto Faculdade de Medicina, Portugal
Projects

Grant

Designation Funders
2017/09 - Current Recoding the Saccharomyces cerevisiae genome
SFRH/BD/121358/2016
PhD Student Fellow
Ongoing
2016/05 - 2017/08 Unravelling the role of mistranslation in the acquisition of drug tolerance and resistance in Candida albicans
PTDC/IMI-MIC/5350/2014
Research Fellow
2015/07 - 2016/04 Consequences of reciprocal control of mistranslation during antifungal immunity
FCT-ANR/IMI-MIC/0041/2012
Research Fellow

Contract

Designation Funders
2022/01/01 - Current Finding new genetic markers of antifungal resistance in the fungal pathogen Candida albicans
Researcher
Fundação para a Ciência e a Tecnologia
2018/07/01 - Current Identification and quantification of protein biosynthesis errors at the proteome scale.
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2024/06/01 - 2026/01/31 O papel do varioma de Candida albicans na sua interação com o hospedeiro humano
Universidade de Aveiro, Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2016/06/01 - 2019/11/30 Exploring the hidden life of RNA modification
PTDC/BEX-BCM/2121/2014
Other
Universidade de Aveiro, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference poster
  1. Guimarães, Ana R.; Ana Rita Macedo Bezerra; Reis, Andreia; Moura, Gabriela; Manuel António da Silva Santos; Pinheiro, Miguel. "PHASEfilter - filtering heterozygous variants from phased genomes". Paper presented in XI Bioinformatics Open Days, 2022.
  2. Guimarães, Ana R.; Pinheiro, Miguel; Reis, Andreia; Moura, Gabriela; Ana Rita Macedo Bezerra; Manuel António da Silva Santos. "Adaptation to codon reassignment induces major genomic and transcriptomic alterations in S. cerevisiae". Paper presented in GenomePT Symposium, 2021.
  3. Guimarães, Ana R.; Ana Rita Macedo Bezerra; Manuel António da Silva Santos. "Reassigning the Saccharomyces cerevisiae genome through codon ambiguities and evolution". Paper presented in IMPSG2020 – International Meeting of the Portuguese Society of Genetics, 2020.
  4. Catarina Brinco; Oliveira, Carla; Edgar Lopes; Guimarães, Ana R.; Manuel António da Silva Santos; Ana Rita Macedo Bezerra. "Mistranslation potentiates antifungal tolerance in Candida albicans". Paper presented in HFP2019: Molecular Mechanisms of Host–Pathogen Interactions and Virulence in Human Fungal Pathogens, 2019.
Journal article
  1. Inês Correia; Carla Oliveira; Andreia Reis; Ana Rita Guimarães; Susana Aveiro; Pedro Domingues; Ana Rita Bezerra; et al. "A Proteogenomic Pipeline for the Analysis of Protein Biosynthesis Errors in the Human Pathogen Candida albicans". Molecular & Cellular Proteomics (2024): https://doi.org/10.1016/j.mcpro.2024.100818.
    10.1016/j.mcpro.2024.100818
  2. Estefanía Lozano Velasco; Jose M Inacio; Inês Sousa; Ana Rita Guimarães; Diego Franco; G.R. Moura; José A. Belo. "miRNAs in Heart Development and Disease". International Journal of Molecular Sciences (2024): http://dx.doi.org/10.3390/ijms25031673.
    10.3390/ijms25031673
  3. Guimarães, Ana R.. "The role of non-standard translation in Candida albicans pathogenesis". FEMS Yeast Research 21 4 (2021): http://dx.doi.org/10.1093/femsyr/foab032.
    10.1093/femsyr/foab032
  4. Guimarães, Ana R.. "tRNAs as a Driving Force of Genome Evolution in Yeast". Frontiers in Microbiology (2021): https://www.frontiersin.org/article/10.3389/fmicb.2021.634004.
    10.3389/fmicb.2021.634004
  5. Bezerra AR; Guimarães AR; Santos MA. "Non-Standard Genetic Codes Define New Concepts for Protein Engineering.". (2015): http://europepmc.org/abstract/med/26569314.
    10.3390/life5041610
Preprint
  1. Inês Correia; Carla Oliveira; Andreia Reis; Ana Rita Guimarães; Susana Aveiro; Pedro Domingues; Ana Rita Bezerra; et al. "A proteogenomic pipeline for the analysis of protein biosynthesis errors in the human pathogenCandida albicans". 2023. http://dx.doi.org/10.1101/2023.10.31.564356.
    10.1101/2023.10.31.564356
  2. Carla Oliveira; Ana Rita Guimarães; Inês Correia; Inês Sousa; Ana Poim; Sílvia M. Rocha; Gabriela Moura; Manuel A. S. Santos; Ana Rita Bezerra. "Filamentation in Candida albicans is modulated by adaptive translation of farnesol signalling genes". 2021. http://dx.doi.org/10.1101/2021.01.20.427544.
    10.1101/2021.01.20.427544
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021 Recoding the yeast genome: an approach to synthetic biology 1st Biomedicine Meeting da Universidade Nova de Lisboa e da Universidade de Aveiro
2018 Re-coding the Saccharomyces cerevisiae genome through codon ambiguities 27th tRNA conference , “tRNA at the crossroad”
(Strasbourg, France)
2018 Re-coding the Saccharomyces cerevisiae genome through experimental evolution Experimental approaches to evolution and ecology using yeast and other model systems
European Molecular Biology Organization (Heidelberg, Germany)
2017 Re-coding the Saccharomyces cerevisiae genome through codon ambiguities XLI Jornadas Portuguesas de Genética

Event organisation

Event name
Type of event (Role)
Institution / Organization
2017 - 2017 Jornadas Portuguesas de Genética (2017)
Congress (Co-organisor)
Universidade de Aveiro, Portugal
2017 - 2017 Simpósio de Biomedicina (2017)
Symposium (Co-organisor)
Universidade de Aveiro, Portugal