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Dr. Carvalho, PI at the Center for Neuroscience and Cell Biology (CNC), University of Coimbra (UC). She studies cellular and molecular mechanisms underlying diabetes, obesity and related complications. She has discovered that low insulin receptor substrate-1 protein levels in fat are predictors of pre-diabetes. She investigates insulin resistance and metabolic dysfunction in adipocytes and how immune cells infiltrate the adipose tissue to cause local tissue inflammation. She is interested in the effect of functional foods in combating insulin resistance and inflammation. Moreover, she has studied wound healing and tissue regeneration in diabetes, with the goal of enhancing early diagnosis of subjects at risk for chronic complications. For instance, she is assessing the role of microRNAs and antimicrobial peptides wound healing and infection. More recently, she was awarded several projects to do work on Non Communicable Diseases (NCDs), particularly obesity, diabetes and complications in Guinea-Bissau, West Africa. One funded by the European Foundation of the study of Diabetes, and others, funded by the Portuguese Cooperation, Camoes Institute. She is evaluating the prevalence of type 2 and type 1 diabetes as well as gestational diabetes, in Guinea-Bissau. She is very interested in studying the impact of mobility and migration on NCDs, particularly diabetes. In addition, a good portion of these projects are dedicated to capacitating and implementing health literacy locally in Guinea-Bissau. Dr. Carvalho and her team are advocates of Health Literacy and Implementation science for the public. She has published ˜170 scientific publications (articles and and abstracts) (h-index=42; >5000 citations; scopus). She has mentored: Post-Docs (˜20); PhDs (˜16); Master (˜20), Erasmus/lab internships (˜30). She has obtained ˜30 travel fellowships from the European Foundation for the Study of Diabetes (EFSD) for young students. She has secured funding from: Europe (H2020-MSCA-ITN-2016 TREATMENT; EFSD; Diabetes UK); NIH (NIGMS-NIH P20GM109096; Pepper Older American Independence Centers; ABI); National (INFARMED; FCT; SPD; SPT), and the Institute Camoes. She is a board member: European Tissue Repair Society, senior editor: J of Endocrinology; J Mol Endocrinology, and reviewer for ˜40 journals and international funding agencies: MRC UK; Israel Sci F; FONDECYT/CONACYT; FWF Der Wissenschaftsfonds; Wellcome Trust; Diabetes UK; French ANR, Horizon Europe PathFinder, and more recently she has been appointed Committee Member for Innovation Fund Denmark, etc. Main research lines: 1 - Insulin resistance 2 - Adipose physiology 3 - Wound healing and tissue regeneration 4 - Oxidative capacity of circulating cells and tissues 5. Health literacy and Diabetes Education Key links https://www.ncbi.nlm.nih.gov/myncbi/1N_kjxvZYzSAP/bibliography/public/ https://www.ncbi.nlm.nih.gov/myncbi/1N_kjxvZYzSAP/bibliography/public/ https://expertscape.com/au/diabetic+foot/Carvalho%2C+E https://orcid.org/0000-0001-6264-3632 https://cordis.europa.eu/project/id/101080329 https://cordis.europa.eu/project/id/721236
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Identification

Personal identification

Full name
EUGÉNIA MARIA LOURENÇO DE CARVALHO

Citation names

  • Carvalho, Eugenia

Author identifiers

Ciência ID
5E11-C215-767E
ORCID iD
0000-0001-6264-3632
Google Scholar ID
https://scholar.google.com/citations?user=AHvtGSEAAAAJ&hl=en
Scopus Author Id
https://www.scopus.com/authid/detail.uri?authorId=35083236900

Email addresses

  • ecarvalh@cnc.uc.pt (Professional)
  • eugeniamlcarvalho@gmail.com (Personal)

Addresses

  • Centro de Neurociências e Biologia Celular - Universidade de Coimbra. Largo Marquês de Pombal , 3004-517, Coimbra, Coimbra, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Clinical Medicine - Endocrinology and Metabolism
  • Medical and Health Sciences - Other Medical Sciences
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Medical and Health Sciences - Health Sciences - Nutrition, Dietetics

Languages

Language Speaking Reading Writing Listening Peer-review
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Portuguese (Mother tongue)
Swedish Proficiency (C2) Proficiency (C2) Upper intermediate (B2) Proficiency (C2)
French Advanced (C1) Proficiency (C2) Intermediate (B1) Proficiency (C2)
Spanish; Castilian Proficiency (C2) Proficiency (C2) Intermediate (B1) Proficiency (C2)
Italian Intermediate (B1) Beginner (A1) Upper intermediate (B2) Elementary (A2)
Education
Degree Classification
1996/06/01 - 2000/09
Concluded
 Gothenburg University (Doctor of Philosophy)
Major in PhD, Molecular Medicine
Göteborgs Universitet, Sweden
"Molecular mechanisms of insulin resistance with emphasis on IRS-1 and PKB/AKT. Molecular phenotyping of fat cells in young first-degree relatives of type 2 diabetic subjects. " (THESIS/DISSERTATION)
1991/06/01 - 1994/06/30
Concluded
 Gothenburg University (Masterexamen)
Major in Biochemistry
Astra Hassle, Sweden
"A study of the active sites of Angiotensin I-Converting Enzyme, Metal and inhibitor binding. " (THESIS/DISSERTATION)
1986/01/01 - 1991/01/01
Attended
 Marymount Manhattan College, NYC, NY, USA (Bachelor)
Major in Chemistry
Marymount Manhattan College, United States
 Magna Cum Laude
Affiliation

Science

Category
Host institution 		Employer
2005/09/01 - Current Principal Investigator (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra, Portugal
2016/02/01 - 2020/12/31 Invited Principal Investigator (Research) University of Arkansas for Medical Sciences, United States
2014 - 2016/01/31 Visiting Researcher (Research) Arkansas Childrens Hospital Research Institute, United States
2007 - 2008 Visiting Researcher (Research) Beth Israel Deaconess Medical Center, United States
2001 - 2005 Postdoc (Research) Harvard Medical School, United States

Teaching in Higher Education

Category
Host institution 		Employer
2005/02/01 - 2005/09/30 Assistant Professor (University Teacher) Universidade do Algarve - Campus de Gambelas, Portugal
Projects

Grant

Designation Funders
2022 - 2027 PAS-GRAS - De-risking metabolic, environmental, and behavioral determinants of obesity in children, adolescents and young-adults
HORIZON-RIA - HORIZON-HLTH-2022-STAYHLTH-01-two-
Co-Principal Investigator (Co-PI)
Universidade de Coimbra, Portugal
Ongoing
2025/01/01 - 2026/12/31 Conhecer a Nutrição: Programa de prevenção da doença através da nutrição saudável, na Guiné-Bissau.
NA
Co-Principal Investigator (Co-PI)
2023 - 2025 Diabetes management, prevention, and education in Guinea-Bissau
Læge Sofus Carl Emil Friis og Hustru Olga Doris Friis' Legat
Co-Principal Investigator (Co-PI)
Ongoing
2023/03/01 - 2024/10/31 Purinergic signaling and metabolism, mycobiota control and obesity
Biocodex
Co-Principal Investigator (Co-PI)
Universidade de Coimbra, Portugal
 Biocodex Centre de recherche
Ongoing
2022/08 - 2024/10 ANGIOHEAL A new view on chronic wound healing treatment: Synergistic interplay between low-dose ionizing radiation and pre-vascularized dermal spheroids.
2022.10387.PTDC
Integration into Research Grant Fellow
Ongoing
2022/04/01 - 2024/01/01 Diabetes diagnosis, management, prevention, and education in Guinea-Bissau
BCG-DM_BG
Ongoing
2022/05/01 - 2022/09/30 Twinning Innovation - Protein enrichment of baked goods for people with special needs
IN-4-AHA-Protein
Co-Principal Investigator (Co-PI)
Universidade de Coimbra, Portugal

Universität Hohenheim, Germany
Ongoing
2018/11/01 - 2021/12/01 Contribution of Psychological Factors in Diabetic Foot Ulcer Healing; in Physiological Indicators of Wound Healing Prognosis and Quality of Life: A Randomized Longitudinal Effectiveness Evaluation
02/SAICT/2017 – SAICT
Other
Fundação para a Ciência e a Tecnologia, Portugal
2018/07/26 - 2021/07/25 Contribution of Psychological Factors in Diabetic Foot Ulcer Healing, in Physiological Indicators of Wound Healing Prognosis and Quality of Life: A Randomized Longitudinal Effectiveness Evaluation Study
PTDC/PSI-GER/28163/2017
Universidade do Minho, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018 - 2021 Antipsychotic drug induced metabolic dysfunction – in vivo studies with 2 specific drugs
H2020-MSCA-ITN-2016
Other
2019/03 - 2020/12 CD20+ T Cells as a biomarker of inflammatory status and a promising target against cardiac rejection in heart transplanted patients
Portuguese Transplant Society
 N/A
2019/01 - 2020/12 MicroRNAs as markers of disturbed adipose tissue function and inflammation - a potential mechanism for diabetes development in obesity
COM Child Health project grant
COM Child Health project grant
Other
University of Arkansas for Medical Sciences, United States
 N/A
Ongoing
2018/02/01 - 2020/01/01 Effects of PTP1b modulation on Wound Healing, in vitro and in vivo systems
17/0005621
Other
Diabetes UK, United Kingdom
 Diabetes UK
Ongoing
2017 - 2019/12/31 Assessment of oxidative capacity in obese children.
NIGMS-NIH P20GM109096
Other
Ongoing
2019/01/01 - 2019/12/01 Role of Regulatory T-cells in Obesity-Linked Insulin Resistance and Diabetes
COM Sturgis project grant
COM Sturgis project grant
Other
University of Arkansas for Medical Sciences, United States
 N/A
2017 - 2019/12 European and Portuguese funds for Human Resources
CENTRO-01-0145-FEDER-000012-N2323
Other
Ongoing
2017 - 2019/12 Establishing the presence of mitochondrial dysfunction and oxidative stress and the relationships with resting energy expenditure and fatty acid oxidation in childhood obesity.
ABI/ACHRI
Other
Ongoing
2017 - 2019/12 Microbiome of the diabetic foot ulcer in human subjects.
INFARMED
Other
Ongoing
2016 - 2018 Combination therapy synergistically accelerates diabetic wound closure.
European Research Program in Microvascular Complications of Diabetes supported by Novartis
Other
European Foundation for the Study of Diabetes, Germany
Concluded
2015/06 - 2016/06 Oxidative capacity of circulating cells and muscle fibers in the elderly
NA
Supervisor
University of Arkansas for Medical Sciences, United States
Concluded
2013/06 - 2016/05 Anticipating diabetes and diabetic wounding for siblings of Type 2 diabetics.
grant.Provided by PTCRIS: 124979
EXCL/DTP-PIC/0069/2012
Associação Protectora dos Diabéticos de Portugal, Portugal

Universidade Nova de Lisboa Medical School, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Stichting Weten

Fundação para a Ciência e a Tecnologia
Concluded
2014/03 - 2015/09 Ageing@Coimbra: A Co-location Centre in the European Knowledge and Innovation Network for Active and Healthy Ageing
grant.Provided by PTCRIS: 135805
EIT-KIC/IVE/0043/2013
Provided by PTCRIS: 135805PRJ
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Administração Regional de Saúde do Centro IP, Portugal

Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal

Universidade do Porto Faculdade de Engenharia, Portugal
Stichting Weten

Fundação para a Ciência e a Tecnologia
Concluded
2012/04 - 2014/09 Neuropeptide release in wounds: a new therapeutic approach for the treatment of diabetic foot ulceration
grant.Provided by PTCRIS: 121109
PTDC/SAU-FAR/121109/2010
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/05 - 2013/10 Dissecting the molecular mechanisms of wound healing in diabetes - the role of neuropeptides
grant.Provided by PTCRIS: 98567
PTDC/SAU-MII/098567/2008
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2021/04/19 - 2023/11/30 Papel da células imunes no metabolismo
CHUC-115-20
Ongoing
2017/10/01 - 2020/09/30 ITN-TREATMENT - Training European Network: Metabolic Dysfunctions associated with Pharmacological Treatment of Schizophrenia
H2020-MSCA-ITN-721236
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Laboratório Associado ICVS 3B's, Portugal

BnML Behavioral and Molecular Lab Lda, Portugal

Centro de Investigación Biomédica en Red de Salud Mental, Spain

Universidade do Minho, Portugal

Instituto de Investigaciones Biomédicas Sols-Morreale, Spain

Universidade de Coimbra, Portugal

Univerza v Ljubljani, Slovenia

Anaxomics, Spain

Hospital Universitario de la Princesa, Spain

Universitat de Lleida, Spain

NIMGenetics Genómica y Medicina SL, Spain

Hebrew University of Jerusalem The David R Bloom Center for Pharmacy, Israel

Uppsala universitet - Campus Gotland, Sweden
EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions
Ongoing
2010/04/01 - 2013/09/30 Detecção do potencial sensibizante de químicos através de um teste in vitro alternativo: uma imposição da nova legislação da União Europeia
PTDC/SAU-OSM/099762/2008
Universidade de Aveiro, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Strategic Project - LA 1 - 2011-2012
PEst-C/SAU/LA0001/2011
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2024/01/01 - 2025/12/31 Empoderar as comunidades para prevenção e cuidados da diabetes, uma abordagem integral e sustentável em Bissau
NA
Co-Principal Investigator (Co-PI)
Ongoing
Outputs

Publications

Book
  1. Smith, U.; Axelsen, M.; Carvalho, E.; Eliasson, B.; Jansson, P.-A.; Wesslau, C.. Insulin signaling and action in fat cells: Associations with insulin resistance and Type 2 diabetes. 1999.
Book chapter
  1. Silva, Fernanda M.; Duarte-Mendes, Pedro; Carvalho, Eugenia; Soares, Carlos; Farinha, Carlos; Serrano, João; Paulo, Rui; et al. Corresponding author: Silva, Fernanda M.. "Effects of combined training during the COVID-19 pandemic on metabolic health and quality of life in sedentary workers: A randomized controlled study.". In Women in science: Aging and public health 2022, edited by Marcia G. Ory; Colette Browning, 155-170. Lausanne: Frontiers Media SA, 2023.
    Published
Conference abstract
  1. Köfalvi (Kofalvi, Käfalvi), Attila ; Morgado, Carla; Pedro, Joana Reis; Lemos, Cristina; Baptista, FI; Gaspar, Joana M.; Ambrósio, António F.; et al. "Streptozotocin-induced type-1 diabetes triggers deregulation of cerebral glucose metabolism identical to genetic deletion of the CB1 cannabinoid receptor". Paper presented in 8th FENS Forum of Neurocience, Barcelona, 2012.
  2. Baptista, FI; Pedro, Joana Reis; Duarte, João; Fernandes, Ângela; Gaspar, Joana; Nogueira, Célia; Carvalho, Eugenia; Ambrósio, António F.; Köfalvi (Kofalvi, Käfalvi), Attila. "Neocortical impairment of glucose homeostasis in the early phase of rat model of type-1 diabetes". Paper presented in Federation of European Neuroscience Societies, Amsterdan, 2010.
Conference paper
  1. Pedroso, D.C.S.; Tellechea, A.; Moura, L.; Fidalgo-Carvalho, I.; Duarte, J.; Carvalho, E.; Ferreira, L.. "Improved survival, vascular differentiation and wound healing potential of stem cells co-cultured with endothelial cells in a fibrin gel". 2011.
Conference poster
  1. Cunha, Ana Filipa; Sousa, Ana Rita; Da Silva, Jessica; Carvalho, Eugenia; Mano, Joao F.; Leal, Ermelindo C; Oliveira, Mariana B.. "Materiais de origem celular como potenciadores de imunossupressão localizada". Paper presented in 20º Congresso Português de Diabetes - 2024, 2024.
  2. Pinho A; Andre Lazaro; Barbosa, Pedro; Diogo Paula; José Campos ; José G. Tralhão; Carvalho, Eugenia. "Nutrient overload and insulin resistance can precede reductions in mitochondrial respiration in omental adipose tissue". Paper presented in IDF Congress 2023, 2023.
  3. Gomes, Ana; Maciel, J.; Ferreira, M.; Plácido, A.; Fernandes, I.; Teixeira, C.; Leal, Ermelindo C; et al. "Peptide-ionic liquid conjugates: paving the way towards a new type of topical treatment for infected wounds". Paper presented in ETRS & SPCE-TC Joint Meeting 2023, 2023.
  4. Da Silva, Jessica; Santos, Diana; Vilaça, Margarida; Jesus, Maria; Carvalho, André; Carvalho, Rui; Pereira, Maria de Graça; Carvalho, Eugenia. "Psychological distress' impact on immune cell distribution and plasma microRNAs in patients with chronic diabetic foot ulcers - a longitudinal study". Paper presented in ETRS & SPCE-TC Joint Meeting 2023, 2023.
  5. Pinho, Aryane; Barbosa, Pedro; Lazaro, André; Paula, Diogo; Campos, José Carlos; Tralhão, José; Paiva, Artur; Laranjeira, Paula; Carvalho, Eugenia. "CD20+ T cells and Mitochondrial Respiration - insights from human studies". Paper presented in XI Jornadas de Cirurgia, Bariatric Sessions 1ª edição, 2023.
  6. Carvalho, Eugenia; Santos, Diana; Vilaça, Margarida; Carvalho, André; Carvalho, Rui; Dantas, Maria Jesus; Pereira, Maria de Graça; Da Silva, Jessica. "Impacto do distress psicológico na distribuição de populações de células imunes e nos níveis de microRNAs em doentes com úlceras crónicas do pé diabético: um estudo longitudinal". Paper presented in 19º Congresso Português de Diabetes - 2023, 2023.
  7. Teixeira, Inês; Da Silva, Jessica; Gomes, Ana; Calheiros, Daniela; Gonçalves, Teresa; Carvalho, Eugenia; Leal, Ermelindo C; Gomes, Paula. "Efeito de um conjugado péptido-líquido iónico inovador no tratamento da ferida diabética". Paper presented in 19º Congresso Português de Diabetes - 2023, 2023.
  8. Bjerregaard-Andersen, Morten; Da Silva, Jessica; Sampaio, M. L.; Claro, A.; Ferro, I.; Romana, A.; Rocha, P.; et al. "Associação entre COVID-19 e incidência de diabetes tipo I em Portugal - um estudo de registo". Paper presented in 19º Congresso Português de Diabetes - 2023, 2023.
  9. Da Silva, Jessica; Leal, Ermelindo C; Gomes, Ana; Gomes, Paula; Carvalho, Eugenia; Silva, E. A.. "Hidrogéis funcionais como sistemas de entrega de péptidos antimicrobianos para o tratamento da úlcera do pé diabético". Paper presented in 19º Congresso Português de Diabetes - 2023, 2023.
  10. Pinho, Aryane; Pedro Barbosa; Lazaro, André; Paula, Diogo; Tralhão, José; Campos, José Carlos; Paiva, Artur; Laranjeira, Paula; Carvalho, Eugenia. "ALTA FREQUÊNCIA DE CÉLULAS T CD 20 NO TECIDO ADIPOSO OMENTAL DE INDIVÍDUOS COM OBESIDADE". Paper presented in 19 º Congresso Português de Diabetes, 2023.
  11. Barbosa, Pedro; Pinho, Aryane; Lazaro, André; Paula, Diogo; Campos, José Carlos; Tralhão, José; Paiva, Artur; Laranjeira, Paula; Carvalho, Eugenia. "Is inflammation an underlying factor for insulin resistance development?". Paper presented in III Metabolism, Aging and Disease Meeting, 2023.
  12. Pinho, Aryane; Pedro Barbosa; Lazaro, André; Campos, José Carlos; Tralhão, José; Paiva, Artur; Laranjeira, Paula; Carvalho, Eugenia. "Increased CD20+ T cell infiltration in omental adipose tissue from patients with obesity". Paper presented in IDF Congress 2022, 2022.
  13. Pedro, Barbosa; Pinho, Aryane; Lazaro André; Paiva, Artur; Laranjeira, Paula; Carvalho, Eugenia; Barbosa, Pedro; et al. "Phenotypic characterization of circulating and adipose tissue infiltrated CD4+ Treg cells". Paper presented in IDF World Diabetes Congress Lisbon and Online, 2022.
  14. Da Silva, J.; Santos, Diana; Moura, João; Vilaça, Margarida; Jesus, Maria; Carvalho, André; Carvalho, Rui; Pereira, M.D.G.; Carvalho, Eugenia. "Effect of distress on circulating microRNA levels and immune cell subpopulation distribution in diabetic foot ulcers". Paper presented in IDF World Diabetes Congress 2022, 2022.
  15. Barbosa, Pedro; Pinho, Aryane; Lazaro, André; Tralhão, José; Campos, José Carlos; Paiva, Artur; Laranjeira, Paula; Carvalho, Eugenia. "Characterization of circulating immune cells in subjects undergoing bariatric surgery". Paper presented in 26º Congresso Portuguesa de Obesidade, 2022.
  16. Santos, Diana; Burgeiro, Ana; Fonseca, Ana Catarina; Baldeiras, Inês; Lourenço, Nuno; Antunes, Manuel; Carvalho, Eugenia. "Oxidative stress is modulated differently in epicardial compared to subcutaneous adipose tissue in heart failure patients.". Paper presented in EMBO Workshop ¿ Energy balance in metabolic disorders, 2022.
  17. Leal, Ermelindo C; Da Silva, Jéssica; Figueiredo, Ana; Tseng, Y.-H.; Carvalho, Eugenia. "Bone morphogenetic protein 7 decreases inflammation and matrix metalloproteinase 9 in improving diabetic wound healing". Paper presented in ETRS Annual Meeting 2022, 2022.
  18. Santos, Diana; Canotilho António; Antunes, Pedro; Coutinho, Gonçalo; Prieto, David; Carvalho, Eugenia. "The impact of diabetes on mitochondrial function in the internal thoracic artery from coronary artery disease patients". Paper presented in Danish Diabetes Association (DDA) Summer School on Diabetes and Metabolism for PhD Students 2022, 2022.
  19. Da Silva, Jessica; Santos, Diana; Moura, João; Vilaça, Margarida; Pereira, Maria de Graça; Carvalho, Eugenia. "O impacto do distress na expressão de microRNAs circulantes e nos níveis de hemoglobina glicada na úlcera do pé diabético". Paper presented in 18º Congresso Português de Diabetes - 2022, 2022.
  20. Leal, Ermelindo C; Da Silva, Jessica; Figueiredo, Ana; Tseng, Y.-H.; Carvalho, Eugenia. "Bone morphogenetic protein-7 promotes diabetic wound healing by decreasing inflammation and matrix metalloproteinase-9 expression". Paper presented in 18º Congresso Português de Diabetes - 2022, 2022.
  21. Fernandes, Rosa; Amorim, Madania; Beatriz Martins; Ribeiro-Rodrigues, Teresa; Girao, Henrique; Conceição Gonçalves; Grimalde Trindade; et al. "Exossomas no fluído lacrimal e sua relação com a retinopatia diabética". Paper presented in 18º Congresso Português de Diabetes, 2022.
  22. Barbosa, Pedro; Pinho, Aryane; Lazaro, André; Laranjeira, Paula; Carvalho, Eugenia. "Modelação das células T reguladoras associada ao fenótipo de insulinorresistência: estudo piloto". Paper presented in 18º Congresso Português de Diabetes, 2022.
  23. Pinho, Aryane; Minuzzi, Luciele; Santos, Diana; Leal, Ermelindo C; Carvalho, Eugenia. "Efeito da diabetes na capacidade de fosforilação oxidativa durante a cicatrização de ferida na pele". Paper presented in 18º Congresso Português de Diabetes, 2022.
  24. Barbosa, Pedro; Graw, Stefan; Byrum, Setphanie D.; Macleod, Stewart; Carvalho, Eugenia. "Alteração dos padrões epigenéticos em crianças com insulinorresistência". Paper presented in 17º Congreesso Português de Diabetes, 2021.
  25. Pinho, Aryane; Burgeiro, Ana; Leal, Ermelindo C; Santos, Diana; Baldeiras, Inês; Carvalho, Eugenia. "UCP-1 regula a função mitocondrial do tecido adipose perivascular da aorta torácica de murganhos diabéticos.". Paper presented in 17º Congresso Português de Diabetes, 2021.
  26. Santos, Diana; Burgeiro, Ana; Fonseca, Ana Catarina; Baldeiras, Inês; Antunes, Manuel Jesus; Carvalho, Eugenia. "Impaired oxidative stress and antioxidant defenses in EAT from cardiac disease patients". Paper presented in XV Congresso Português de Transplantação, 2021.
  27. Pinho, Aryane; Baldeiras, Inês; Santos, Diana; Leal, Ermelindo C; Burgeiro, Ana; Carvalho, Eugenia. "Oxidative stress and mitochondrial bioenergetic in toracic periaortic versus subcutaneous fat in a mouse model of diabetes". Paper presented in XV Congresso Português de Transplantação, 2021.
  28. Pinho, A. C. O.; Baldeiras, Ines; Santos, Diana; Leal, Ermelindo C; Burgeiro, Ana; Carvalho, Eugenia. "Oxidative stress and mitochondrial bioenergetics in thoracic periaortic versus subcutaneous fat in a mouse model of diabetes.". Paper presented in XV Congresso Português de Transplantação, 2021.
  29. Pinho, A. C. O.; Baldeiras, Ines; Santos, Diana; Leal, Ermelindo C; Burgeiro, Ana; Carvalho, Eugenia. "UCP-1 regula a função mitocondrial do tecido adiposo perivascular da aorta torácica de murganhos diabéticos.". Paper presented in 17º Congresso Português de Diabetes, 2021.
  30. Pinho, A. C. O.; Burgeiro, Ana; Leal, Ermelindo C; Carvalho, Eugenia. "Uncoupling protein 1 and its effects on mitochondrial bioenergetics in perivascular adipose tissue of the thoracic aorta of diabetic mice". Paper presented in 24º CONGRESSO PORTUGUÊS DE OBESIDADE, 2020.
  31. Barbosa, Pedro; Graw, Stefan; Byrum, Stephanie; Macleod, Stewart; Landes, Reid D; Carvalho, Eugenia. "DNA methylation of peripheral blood mononuclear cells from obese children". Paper presented in 24º Congresso Português de Obesidade, 2020.
  32. Minuzzi, LG; Leal, Ermelindo C; Diana Santos; Carvalho, Eugenia; Santos, Diana; Leal, Ermelindo. "Assessment of mitochondrial function in skin biopsies by respirometry as a biosensitive marker of diabetic wound progression". Paper presented in 16th Congress of the Portuguese Society of Diabetes, 2020.
  33. Figueiredo, Ana; Leal, Ermelindo C; Santos, Diana; Gasiunaite, Gerda; Delibegovic, Mirella; Carvalho, Eugenia. "A inibição da proteína tirosina fosfatase 1B potencia o fenótipo de macrófagos anti-inflamatórios, em condições de alta glucose, podendo beneficiar a cicatrização de férias diabéticas.". Paper presented in 16º Congresso Português da Diabetes,, 2020.
  34. Santos, Diana; Burgeiro, Ana; Fonseca, Ana Catarina; Baldeiras, Inês; Antunes, Manuel Jesus; Dalgaard, Louise; Carvalho, Eugenia. "MicroRNA34a is associated with an increase in oxidative stress in epicardial adipose tissue.". Paper presented in 16o Congresso Português da Diabetes, 2020.
  35. Leal, Ermelindo C; Figueiredo, Ana; Carvalho, Eugenia. Corresponding author: Leal, Ermelindo C. "Neurotensin Improves Endothelial Progenitor Cell Function In Diabetic Wound Healing. *corresponding author". Paper presented in 80th Scientific Session ADA, 2020.
  36. Figueiredo, Ana; Leal, Ermelindo C; Santos, Diana; Gasiunaite, Gerda; Delibegovic, Mirela; Carvalho, Eugenia. Corresponding author: Leal, Ermelindo C. "Protein Tyrosine Phosphatase 1B Inhibitor, MSI-1436, Promotes M2 Macrophage Polarization And Decreases Oxidative Stress In Human Monocytes Under High Glucose Conditions. *corresponding author". Paper presented in 80th Scientific Sessions ADA, 2020.
  37. Di Nunzio, Giada; Santamaria, Raphael; Fonseca, Ana Catarina; Petkovic, Marija; Santos, Diana; Piscosquito, Arianna; Carvalho, Eugenia; Jones, John. "Impact of second generation antipsychotics on insulin sensitivity and mitochondrial bioenergetics after acute treatment in rats.". Paper presented in 55th Annual Meeting of the European Association for the Study of Diabetes, 2019.
  38. Figueiredo, Ana; Leal, Ermelindo C; Santos, Diana; Gasiunaite, Gerda; Delibegovic, Mirella; Carvalho, Eugenia. "Protein tyrosine phosphatase 1B inhibition plays a role in the macrophage phenotype under high Page 4 of 5 glucose conditions: potential therapy for for diabetic wound healing. ,". Paper presented in 55th Annual Meeting of the European Association for the Study of Diabetes, 2019.
  39. Di Nunzio, Giada; Santamaria, Raphael; Fonseca, Ana Catarina; Petkovic, Marija; Santos, Diana; Piscoquito, Arianna; Carvalho, Eugenia; Jones, John. "Impact of second-generational antipsychotics on mitochondrial bioenergetics after acute treatment in rats.". Paper presented in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation, 2019.
  40. Minuzzi, Luciele Guerra; Fonseca, Ana Catarina; Leal, Ermelindo C; Carvalho, Eugenia; Santos, Diana. "High-Resolution Respirometry for Mitochondrial Function Analysis in Skin of Diabetic Rodents". Paper presented in 15 Portuguese Congress of Diabetes, 2019.
  41. Pinho, Aryane; Burgeiro, Ana; Antunes, Pedro; Carvalho, Eugenia. "Efeitos de fármacos no tecido adiposo epicardial -impacto na função cardíaca.". Paper presented in 15º Congresso Português de Diabetes, 2019.
  42. Pereira, Sónia Gonçalves; Alarico, Susana; Leal, Ermelindo C; Carvalho, Eugenia; Nuno Empadinhas. "Microcare project: the impact and potentiality of microbes in diabetic skin and ulcers". Paper presented in 15th Portuguese Diabetes Society Conference, 2019.
  43. Di Nunzio, Giada; Santamaria, Rapahel; Fonseca, Ana Catarina; Santos, Diana; Petkovic, Marija; Carvalho, Eugenia. "Effect of olanzapine on mitochondria function after three and six weeks of treatment in rats.". Paper presented in MitoPorto, 2018.
  44. Fonseca, Ana Catarina; Burgeiro, Ana; Dias, Cândida; Baldeiras, Inês; Cunha-Oliveira, Teresa; Lourenço, Nuno; Costa-Nunes, João; et al. "Mitochondrial function and oxidative stress in diabetic and non-diabetic human epicardial versus subcutaneous adipose tissue.". Paper presented in Mitoporto, Mitochondrial evolution, metabolism and disease,, 2018.
  45. Flávio Reis; Sara Nunes; Sofia D. Viana; Ana Burgeiro; Eugénia Carvalho; Frederico C. Pereira; Maria Alexandra André; et al. "Alterações cardíacas precoces num modelo de pré-diabetes induzida por dieta hipercalórica - estudo molecular e de imagem funcional". Paper presented in 14º Congresso Português de Diabetes, 2018.
  46. Santos, Diana; Burgeiro, Ana; Fonseca, Ana Catarina; Lourenço, Nuno; Antunes, Manuel; Carvalho, Eugenia. "Quality control mechanisms are upregulated in epicardial adipose tissue from heart failure patients". Paper presented in 14º Congresso Português da Diabetes,, 2018.
  47. Pinho, Aryane; Burgeiro, Ana; Fonseca, Ana Catarina; Nunes, João Costa; Serafim, Patrícia; Baldeiras, Inês; Antunes, Manuel; Carvalho, Eugenia. "Epicardial adipose tissue has less oxidative stress than subcutaneous adipose tissue". Paper presented in 14º Congresso Português de Diabetologia, 2018.
  48. Fonseca, Ana Catarina; Burgeiro, Ana; Lourenço, Nuno; Nunes, João Costa; Santos, Diana; Pinho, Aryane Cruz Oliveira; Leal, Ermelindo; et al. "Mitochondrial function and oxidative stress in epicardial versus subcutaneous adipose tissue from heart failure patients with and without diabetes". Paper presented in Mito-Porto, 2018.
Journal article
  1. Aryane Cruz Oliveira Pinho; Pedro Barbosa; André Lazaro; José G. Tralhão; Maria João Pereira; Artur Paiva; Paula Laranjeira; Eugenia Carvalho. "Identification and characterization of circulating and adipose tissue infiltrated CD20+ T cells from subjects with obesity that undergo bariatric surgery". Immunology Letters (2024): https://doi.org/10.1016/j.imlet.2024.106911.
    10.1016/j.imlet.2024.106911
  2. Aryane Cruz Oliveira Pinho; Pedro Barbosa; Maria João Pereira; Artur Paiva; Eugenia Carvalho; Paula Laranjeira. "The role of CD20+ T cells: Insights in human peripheral blood". Cytometry Part B: Clinical Cytometry (2024): https://doi.org/10.1002/cyto.b.22178.
    10.1002/cyto.b.22178
  3. Pedro Barbosa; Aryane Pinho; André Lázaro; Diogo Paula; José G. Tralhão; Artur Paiva; Maria J. Pereira; Eugenia Carvalho; Paula Laranjeira. "Bariatric Surgery Induces Alterations in the Immune Profile of Peripheral Blood T Cells". Biomolecules (2024): https://doi.org/10.3390/biom14020219.
    10.3390/biom14020219
  4. Aryane Cruz Oliveira Pinho; Paula Laranjeira; Eugenia Carvalho. "Role of CD20+ T cells in cancer, autoimmunity and obesity". Journal of Endocrinology (2024): https://doi.org/10.1530/JOE-23-0242.
    10.1530/JOE-23-0242
  5. Aryane Cruz Oliveira Pinho; Diana Santos; Paulo J. Oliveira; Ermelindo Carreira Leal; Eugenia Carvalho. "Real-time OXPHOS capacity analysis in wounded skin from diabetic mice: A pilot study". European Journal of Clinical Investigation (2023): https://doi.org/10.1111/eci.14128.
    10.1111/eci.14128
  6. Jessica Da Silva; Diana Santos; Margarida Vilaça; André Carvalho; Rui Carvalho; Maria de Jesus Dantas; M. Graça Pereira; Eugénia Carvalho. "Impact of Psychological Distress on Physiological Indicators of Healing Prognosis in Patients with Chronic Diabetic Foot Ulcers: A Longitudinal Study". Advances in Wound Care (2023): https://doi.org/10.1089/wound.2023.0043.
    10.1089/wound.2023.0043
  7. M. Graça Pereira; Margarida Vilaça; Diogo Braga; Ana Madureira; Jéssica Da Silva; Diana Santos; Eugénia Carvalho. "Healing profiles in patients with a chronic diabetic foot ulcer: An exploratory study with machine learning". Wound Repair and Regeneration (2023): https://doi.org/10.1111/wrr.13141.
    10.1111/wrr.13141
  8. Alphonse Laya; Honoré Wangso; Iva Fernandes; Raphaël Djakba; Joana Oliveira; Eugenia Carvalho; Wen yi Kang. "Bioactive Ingredients in Traditional Fermented Food Condiments: Emerging Products for Prevention and Treatment of Obesity and Type 2 Diabetes". Journal of Food Quality (2023): https://doi.org/10.1155/2023/5236509.
    10.1155/2023/5236509
  9. Jessica Da Silva; Ermelindo C. Leal; Eugénia Carvalho; Eduardo A. Silva. "Innovative Functional Biomaterials as Therapeutic Wound Dressings for Chronic Diabetic Foot Ulcers". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24129900.
    10.3390/ijms24129900
  10. Ermelindo C Leal; Tatiana Emanuelli; Diana Santos; João Moura; Ana Catarina RG Fonseca; Ana Burgeiro; Eugenia Carvalho. "Dysregulation of endoplasmic reticulum stress response in skin wounds in a streptozotocin-induced diabetes mouse model". Journal of Molecular Endocrinology (2023): https://doi.org/10.1530/JME-22-0122.
    10.1530/JME-22-0122
  11. Ines D. Teixeira; Eugenia Carvalho; Ermelindo C. Leal. "Green Antimicrobials as Therapeutic Agents for Diabetic Foot Ulcers". Antibiotics (2023): https://doi.org/10.3390/antibiotics12030467.
    10.3390/antibiotics12030467
  12. Pedro Barbosa; Eugenia Carvalho. "Are Dietary Sugars Potent Adipose Tissue and Immune Cell Modulators?". Diabetology (2023): https://doi.org/10.3390/diabetology4010005.
    10.3390/diabetology4010005
  13. Diana Santos; Patricia Porter-Gill; Grace Goode; Leanna Delhey; Anja Elaine Sørensen; Shannon Rose; Elisabet Børsheim; Louise Torp Dalgaard; Eugenia Carvalho. "Circulating microRNA levels differ in the early stages of insulin resistance in prepubertal children with obesity". Life Sciences (2023): https://doi.org/10.1016/j.lfs.2022.121246.
    10.1016/j.lfs.2022.121246
  14. Ermelindo Carreira Leal; Eugenia Carvalho. "Heme Oxygenase-1 as Therapeutic Target for Diabetic Foot Ulcers". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms231912043.
    10.3390/ijms231912043
  15. M. Graça Pereira; Margarida Vilaça; Eugenia Carvalho. "Effectiveness of Two Stress Reduction Interventions in Patients with Chronic Diabetic Foot Ulcers (PSY-DFU): Protocol for a Longitudinal RCT with a Nested Qualitative Study Involving Family Caregivers". International Journal of Environmental Research and Public Health (2022): https://doi.org/10.3390/ijerph19148556.
    10.3390/ijerph19148556
  16. Iva Fernandes; Joana Oliveira; Aryane Pinho; Eugenia Carvalho. "The Role of Nutraceutical Containing Polyphenols in Diabetes Prevention". Metabolites (2022): https://doi.org/10.3390/metabo12020184.
    10.3390/metabo12020184
  17. Pinho, Aryane Cruz Oliveira; Santos, Diana; Baldeiras, Ines; Burgeiro, Ana; Leal, Emelindo C.; Carvalho, Eugenia. "Mitochondrial respiration in thoracic perivascular adipose tissue of diabetic mice". Journal of Endocrinology (2022): https://publons.com/wos-op/publon/51171420/.
    10.1530/JOE-21-0446
  18. Diana Santos; Eugenia Carvalho. "Adipose-related microRNAs as modulators of the cardiovascular system: the role of epicardial adipose tissue". The Journal of Physiology (2021): https://doi.org/10.1113/JP280917.
    10.1113/JP280917
  19. Leal, EC; Moura, LI; Pirzgalska, RM; Dorinda Marques-da-Silva; Catherine Ledent; Attila Köfalvi; Carvalho, Eugenia. "Diabetes and Cannabinoid CB1 receptor deficiency promote similar early onset aging-like changes in the skin.". Experimental gerontology 154 (2021): 111528. https://doi.org/10.1016/j.exger.2021.111528.
    Published • 10.1016/j.exger.2021.111528
  20. Pedro Barbosa; Stepan Melnyk; Sirish C. Bennuri; Leanna Delhey; Andreia Reis; Gabriela R. Moura; Elisabet Børsheim; et al. "Redox Imbalance and Methylation Disturbances in Early Childhood Obesity". Oxidative Medicine and Cellular Longevity (2021): https://doi.org/10.1155/2021/2207125.
    10.1155/2021/2207125
  21. Hélia Fernandes; João Moura; Eugénia Carvalho; H. Fernandes; João Moura Alves; Carvalho, Eugenia. "mTOR Signaling as a Regulator of Hematopoietic Stem Cell Fate". Stem Cell Reviews and Reports (2021): https://doi.org/10.1007/s12015-021-10131-z.
    Accepted • 10.1007/s12015-021-10131-z
  22. Isadora Pombeiro; João Moura; Maria Graça Pereira; Eugénia Carvalho. "Stress-Reducing Psychological Interventions as Adjuvant Therapies for Diabetic Chronic Wounds". Current Diabetes Reviews (2021): https://doi.org/10.2174/1573399817666210806112813.
    10.2174/1573399817666210806112813
  23. Petkovic, Marija; Leal, Ermelindo C; Alves, Ines; Bose, Chanda; Palade, Philip T; Singh, Preeti; Awasthi, Sanjay; et al. "Dietary supplementation with sulforaphane ameliorates skin aging through activation of the Keap1-Nrf2 pathway". The Journal of Nutritional Biochemistry (2021): 108817. http://dx.doi.org/10.1016/j.jnutbio.2021.108817.
    10.1016/j.jnutbio.2021.108817
  24. Chen, Jin-Ran; Lazarenko, Oxana P; Carvalho, Eugenia; Blackburn, Michael L; Shankar, Kartik; Wankhade, Umesh D; Børsheim, Elisabet. "Short-Term Increased Physical Activity During Early Life Affects High-Fat Diet–Induced Bone Loss in Young Adult Mice". JBMR Plus 5 7 (2021): http://dx.doi.org/10.1002/jbm4.10508.
    10.1002/jbm4.10508
  25. Pinho, Aryane Cruz Oliveira; Ana Burgeiro; Maria João Rodrigues Pereira (1513-EB2F-0D7F); Carvalho, Eugenia; ARYANE C.O. PINHO; MARIA JOÃO PEREIRA; EUGENIA CARVALHO. "Drug-induced metabolic alterations in adipose tissue - with an emphasis in epicardial". Annals of the Brazilian Academy of Sciences 94 1 (2021): https://doi.org/10.1590/0001-3765202220201819.
    Accepted • 10.1590/0001-3765202220201819
  26. Mouritzen MV; Petkovic, Marija; Qvist K; Poulsen SS; Alarico S; Leal, EC; Dalgaard LT; et al. "Improved diabetic wound healing by bovine lactoferricin is associated with relevant changes in the skin immune response and microbiota". Molecular Therapy - Methods & Clinical Development (2021):
    Accepted
  27. Da Silva, Jessica; Leal, Ermelindo C.; Carvalho, Eugenia; Jessica Da Silva; Leal, Ermelindo C; Eugénia Carvalho. Corresponding author: Leal, Ermelindo C. "Bioactive Antimicrobial Peptides as Therapeutic Agents for Infected Diabetic Foot Ulcers". Biomolecules (2021): http://hdl.handle.net/10316/103768.
    https://doi.org/10.3390/biom11121894
  28. Bose, Chhanda; Alves, Ines; Singh, Preeti; Palade, Philip T.; Carvalho, Eugenia; Børsheim, Elisabet; Jun, Se-Ran; et al. "Sulforaphane prevents age-associated cardiac and muscular dysfunction through Nrf2 signaling". Aging Cell 19 11 (2020): http://dx.doi.org/10.1111/acel.13261.
    10.1111/acel.13261
  29. Petkovic, Marija; Sørensen, Anja Elaine; Leal, Ermelindo Carreira; Carvalho, Eugenia; Dalgaard, Louise Torp. "Mechanistic Actions of microRNAs in Diabetic Wound Healing". Cells 9 10 (2020): 2228. http://dx.doi.org/10.3390/cells9102228.
    10.3390/cells9102228
  30. Figueiredo, Ana; Leal, Ermelindo C.; Carvalho, Eugénia. "Protein tyrosine phosphatase 1B inhibition as a potential therapeutic target for chronic wounds in diabetes". Pharmacological Research 159 (2020): 104977. http://dx.doi.org/10.1016/j.phrs.2020.104977.
    10.1016/j.phrs.2020.104977
  31. Jun, Se-Ran; Cheema, Amrita; Bose, Chhanda; Boerma, Marjan; Palade, Philip T.; Carvalho, Eugenia; Awasthi, Sanjay; Singh, Sharda P.. "Multi-Omic Analysis Reveals Different Effects of Sulforaphane on the Microbiome and Metabolome in Old Compared to Young Mice". Microorganisms 8 10 (2020): 1500. http://dx.doi.org/10.3390/microorganisms8101500.
    10.3390/microorganisms8101500
  32. Pedro, Joana Reis; Moura, Liane I.F.; Valério-Fernandes, Ângela; Baptista, Filipa I.; Gaspar, Joana M.; Pinheiro, Bárbara S.; Lemos, Cristina; et al. "Transient gain of function of cannabinoid CB1 receptors in the control of frontocortical glucose consumption in a rat model of Type-1 diabetes". Brain Research Bulletin 161 (2020): 106-115. http://dx.doi.org/10.1016/j.brainresbull.2020.05.004.
    10.1016/j.brainresbull.2020.05.004
  33. Seraphim, Patricia M.; Leal, Ermelindo C.; Moura, João; Gonçalves, Pedro; Gonçalves, Jenifer P.; Carvalho, Eugénia. "Lack of lymphocytes impairs macrophage polarization and angiogenesis in diabetic wound healing". Life Sciences 254 (2020): 117813. http://dx.doi.org/10.1016/j.lfs.2020.117813.
    10.1016/j.lfs.2020.117813
  34. Carvalho, Eugenia; Adams, Sean H.; Børsheim, Elisabet; Blackburn, Michael L.; Ono-Moore, Kikumi D.; Cotter, Matthew; Bowlin, Anne K.; Yeruva, Laxmi. "Neonatal diet impacts liver mitochondrial bioenergetics in piglets fed formula or human milk". BMC Nutrition 6 1 (2020): http://dx.doi.org/10.1186/s40795-020-00338-7.
    10.1186/s40795-020-00338-7
  35. Chen, J. R.; Lazarenko, O.; Carvalho, Eugenia; Sankar, K.; Børsheim, Elisabet. "Increased Physical Activity during Early Life Exacerbates High Fat Diet-Induced Bone Loss in Adult Mice". Science Reports (2020):
    Submitted
  36. Rose, Shannon; Carvalho, Eugenia; Diaz, Eva C.; Cotter, Matthew; Bennuri, Sirish C.; Azhar, Gohar; Frye, Richard E.; Adams, Sean H.; Børsheim, Elisabet. "A comparative study of mitochondrial respiration in circulating blood cells and skeletal muscle fibers in women". American Journal of Physiology-Endocrinology and Metabolism 317 3 (2019): E503-E512. http://dx.doi.org/10.1152/ajpendo.00084.2019.
    10.1152/ajpendo.00084.2019
  37. Henriques-Antunes, Helena; Cardoso, Renato M. S.; Zonari, Alessandra; Correia, Joana; Leal, Ermelindo C.; Jiménez-Balsa, Adrián; Lino, Miguel M.; et al. "The Kinetics of Small Extracellular Vesicle Delivery Impacts Skin Tissue Regeneration". ACS Nano 13 8 (2019): 8694-8707. http://dx.doi.org/10.1021/acsnano.9b00376.
    10.1021/acsnano.9b00376
  38. Moura, João; Rodrigues, João; Gonçalves, Marta; Amaral, Cláudia; Lima, Margarida; Carvalho, Eugénia. "Imbalance in T-cell differentiation as a biomarker of chronic diabetic foot ulceration". Cellular & Molecular Immunology (2019): http://dx.doi.org/10.1038/s41423-019-0233-1.
    10.1038/s41423-019-0233-1
  39. Moura, João; Sørensen, Anja; Leal, Ermelindo C.; Svendsen, Rikke; Carvalho, Lina; Willemoes, Rie Juul; Jørgensen, Per Trolle; et al. "microRNA-155 inhibition restores Fibroblast Growth Factor 7 expression in diabetic skin and decreases wound inflammation". Scientific Reports 9 1 (2019): http://dx.doi.org/10.1038/s41598-019-42309-4.
    10.1038/s41598-019-42309-4
  40. Carvalho, Eugenia. "Establishing a Link Between Endothelial Cell Metabolism and Vascular Behaviour in a Type 1 Diabetes Mouse Model". Cellular Physiology and Biochemistry 52 3 (2019): 503-516. http://dx.doi.org/10.33594/000000036.
    10.33594/000000036
  41. Moura, J.; Madureira, P.; Leal, E.C.; Fonseca, A.C.; Carvalho, E.. "Immune aging in diabetes and its implications in wound healing". Clinical Immunology 200 (2019): 43-54. http://dx.doi.org/10.1016/j.clim.2019.02.002.
    10.1016/j.clim.2019.02.002
  42. Liane I.F. Moura; Cristina Lemos; Catherine Ledent; Eugénia Carvalho; Attila Köfalvi. "Chronic insulinopenia/hyperglycemia decrease cannabinoid CB1 receptor density and impair glucose uptake in the mouse forebrain". Brain Research Bulletin (2019): https://doi.org/10.1016/j.brainresbull.2019.01.024.
    10.1016/j.brainresbull.2019.01.024
  43. Louise T. Dalgaard; Eugenia Carvalho. "Wanted: MicroRNAs to the aid of the diabetic foot". Trends in Cardiovascular Medicine (2018): https://doi.org/10.1016/j.tcm.2018.09.002.
    10.1016/j.tcm.2018.09.002
  44. Ana Catarina R. G. Fonseca; Eugénia Carvalho; Jan W. Eriksson; Maria J. Pereira. "Calcineurin is an important factor involved in glucose uptake in human adipocytes". Molecular and Cellular Biochemistry 445 1-2 (2018): 157-168. https://doi.org/10.1007/s11010-017-3261-0.
    10.1007/s11010-017-3261-0
  45. Michelle V. Mouritzen; Sali Abourayale; Rooshanie Ejaz; Christine B. Ardon; Eugenia Carvalho; Louise T. Dalgaard; Martin Roursgaard; Håvard Jenssen. "Neurotensin, substance P, and insulin enhance cell migration". Journal of Peptide Science 24 7 (2018): e3093-e3093. https://doi.org/10.1002/psc.3093.
    10.1002/psc.3093
  46. Marquis, Bryce J; Hurren, Nicholas M; Carvalho, Eugenia; Kim, Il-Young; Schutzler, Scott; Azhar, Gohar; Wolfe, Robert R; Børsheim, Elisabet. "Skeletal Muscle Acute and Chronic Metabolic Response to Essential Amino Acid Supplementation in Hypertriglyceridemic Older Adults". Current Developments in Nutrition 1 11 (2017): e002071. http://dx.doi.org/10.3945/cdn.117.002071.
    10.3945/cdn.117.002071
  47. Moura J; Rodrigues J; Gonçalves M; Amaral C; Lima M; Carvalho E. "Impaired T-cell differentiation in diabetic foot ulceration.". Cellular & molecular immunology (2017): http://europepmc.org/abstract/med/26996067.
    10.1038/cmi.2015.116
  48. Burgeiro A; Cerqueira MG; Varela-Rodríguez BM; Nunes S; Neto P; Pereira FC; Reis F; Carvalho E. "Glucose and Lipid Dysmetabolism in a Rat Model of Prediabetes Induced by a High-Sucrose Diet.". Nutrients (2017): http://europepmc.org/abstract/med/28635632.
    10.3390/nu9060638
  49. Pereira SG; Moura J; Carvalho E; Empadinhas N. "Microbiota of Chronic Diabetic Wounds: Ecology, Impact, and Potential for Innovative Treatment Strategies.". Frontiers in microbiology (2017): http://europepmc.org/abstract/med/28983285.
    10.3389/fmicb.2017.01791
  50. Alves, João; Petkovic, Marija; Anja Elaine Sørensen; Leal, Ermelindo C; Rie Juul Willemoes; P.T. Jørgensen; Jesper Wengel; Carvalho, Eugenia; Louise Torp Dalgaard. "Regulation of miRNA-146a and miR-29a during wound healing in a mouse model of type 1 diabetes". Diabetologia 60 Suppl. 1 (2017): 120-120.
    Published • 10.1007/s00125-017-4350-z
  51. Emanuelli T; Burgeiro A; Carvalho E. "Effects of insulin on the skin: possible healing benefits for diabetic foot ulcers.". Archives of dermatological research (2016): http://europepmc.org/abstract/med/27655635.
    10.1007/s00403-016-1686-z
  52. García-Casarrubios E; de Moura C; Arroba AI; Pescador N; Calderon-Dominguez M; Garcia L; Herrero L; et al. "Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes.". Biochimica et biophysica acta (2016): http://europepmc.org/abstract/med/27686967.
    10.1016/j.bbalip.2016.09.016
  53. Tellechea A; Leal EC; Kafanas A; Auster ME; Kuchibhotla S; Ostrovsky Y; Tecilazich F; et al. "Mast Cells Regulate Wound Healing in Diabetes.". Diabetes (2016): http://europepmc.org/abstract/med/27207516.
    10.2337/db15-0340
  54. Carvalho E; Lopaschuk GD; Børsheim E; Burgeiro A. "Reply to Katlandur, Ozbek, and Keser.". American journal of physiology. Endocrinology and metabolism (2016): http://europepmc.org/abstract/med/27182058.
    10.1152/ajpendo.00113.2016
  55. Burgeiro A; Fuhrmann A; Cherian S; Espinoza D; Jarak I; Carvalho RA; Loureiro M; et al. "Glucose uptake and lipid metabolism are impaired in epicardial adipose tissue from heart failure patients with or without diabetes.". American journal of physiology. Endocrinology and metabolism (2016): http://europepmc.org/abstract/med/26814014.
    10.1152/ajpendo.00384.2015
  56. Carvalho, Eugenia. "Substance P Promotes Wound Healing in Diabetes by Modulating Inflammation and Macrophage Phenotype". Am J Pathol (2015): http://www.ncbi.nlm.nih.gov/pubmed/25871534.
  57. Sereno, J.; Vala, H.; Nunes, S.; Rocha-Pereira, P.; Carvalho, E.; Alves, R.; Teixeira, F.; Reis, F.. "Cyclosporine a-induced nephrotoxicity is ameliorated by dose reduction and conversion to sirolimus in the rat". Journal of Physiology and Pharmacology 66 2 (2015): 285-299. http://www.scopus.com/inward/record.url?eid=2-s2.0-84927565139&partnerID=MN8TOARS.
  58. Godinho R; Mega C; Teixeira-de-Lemos E; Carvalho E; Teixeira F; Fernandes R; Reis F. "The Place of Dipeptidyl Peptidase-4 Inhibitors in Type 2 Diabetes Therapeutics: A "Me Too" or "the Special One" Antidiabetic Class?". Journal of diabetes research (2015): http://europepmc.org/abstract/med/26075286.
    10.1155/2015/806979
  59. Tellechea, Ana; Kafanas, Antonios; Leal, Ermelindo C.; Auster, Michael E.; Kuchibhotla, Sarada; Ostrovsky, Yana; Carvalho, Eugenia; et al. "Mast Cell Stabilization: A Potential Treatment for Diabetic Wounds". Diabetes 64 2 (2015): A182-A183. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000359482700702&KeyUID=WOS:000359482700702.
  60. Lopes, P.C.; Fuhrmann, A.; Sereno, J.; Espinoza, D.O.; Pereira, M.J.; Eriksson, J.W.; Reis, F.; Carvalho, E.. "Short and long term in vivo effects of Cyclosporine A and Sirolimus on genes and proteins involved in lipid metabolism in Wistar rats". Metabolism: Clinical and Experimental 63 5 (2014): 702-715. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899413762&partnerID=MN8TOARS.
    10.1016/j.metabol.2014.02.004
  61. Da Silva, L.P.; Neves, B.M.; Moura, L.; Cruz, M.T.; Carvalho, E.. "Neurotensin decreases the proinflammatory status of human skin fibroblasts and increases epidermal growth factor expression". International Journal of Inflammation 2014 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84907386743&partnerID=MN8TOARS.
    10.1155/2014/248240
  62. Moura, L.I.; Cruz, M.T.; Carvalho, E.. "The effect of neurotensin in human keratinocytes - implication on impaired wound healing in diabetes". Experimental Biology and Medicine 239 1 (2014): 6-12. http://www.scopus.com/inward/record.url?eid=2-s2.0-84891928865&partnerID=MN8TOARS.
    10.1177/1535370213510665
  63. Moura, J.; Børsheim, E.; Carvalho, E.. "The role of micrornas in diabetic complications—special emphasis on wound healing". Genes 5 4 (2014): 926-956. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919594907&partnerID=MN8TOARS.
    10.3390/genes5040926
  64. Sereno, J.; Rodrigues-Santos, P.; Vala, H.; Rocha-Pereira, P.; Alves, R.; Fernandes, J.; Santos-Silva, A.; et al. "Transition from cyclosporine-induced renal dysfunction to nephrotoxicity in an in vivo rat model". International Journal of Molecular Sciences 15 5 (2014): 8979-8997. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901366149&partnerID=MN8TOARS.
    10.3390/ijms15058979
  65. Lopes, P.C.; Fuhrmann, A.; Carvalho, F.; Sereno, J.; Santos, M.R.; Pereira, M.J.; Eriksson, J.W.; Reis, F.; Carvalho, E.. "Cyclosporine A enhances gluconeogenesis while sirolimus impairs insulin signaling in peripheral tissues after 3 weeks of treatment". Biochemical Pharmacology 91 1 (2014): 61-73. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905441039&partnerID=MN8TOARS.
    10.1016/j.bcp.2014.06.014
  66. Fuhrmann, A.; Lopes, P.; Sereno, J.; Pedro, J.; Espinoza, D.O.; Pereira, M.J.; Reis, F.; Eriksson, J.W.; Carvalho, E.. "Molecular mechanisms underlying the effects of cyclosporin A and sirolimus on glucose and lipid metabolism in liver, skeletal muscle and adipose tissue in an in vivo rat model". Biochemical Pharmacology 88 2 (2014): 216-228. http://www.scopus.com/inward/record.url?eid=2-s2.0-84895553061&partnerID=MN8TOARS.
    10.1016/j.bcp.2014.01.020
  67. Moura, L.I.F.; Dias, A.M.A.; Leal, E.C.; Carvalho, L.; De Sousa, H.C.; Carvalho, E.; Moura, Liane I F; et al. "Chitosan-based dressings loaded with neurotensin - An efficient strategy to improve early diabetic wound healing". Acta Biomaterialia 10 2 (2014): 843-857. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896548394&partnerID=MN8TOARS.
    10.1016/j.actbio.2013.09.040
  68. Tecilazich, F.; Dinh, T.; Pradhan-Nabzdyk, L.; Leal, E.; Tellechea, A.; Kafanas, A.; Gnardellis, C.; et al. "Role of endothelial progenitor cells and inflammatory cytokines in healing of diabetic foot ulcers". PLoS ONE 8 12 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84892726746&partnerID=MN8TOARS.
    10.1371/journal.pone.0083314
  69. Moura, L.I.F.; Dias, A.M.A.; Carvalho, E.; De Sousa, H.C.. "Recent advances on the development of wound dressings for diabetic foot ulcer treatment - A review". Acta Biomaterialia 9 7 (2013): 7093-7114. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878278772&partnerID=MN8TOARS.
    10.1016/j.actbio.2013.03.033
  70. Sereno, J.; Parada, B.; Rodrigues-Santos, P.; Lopes, P.C.; Carvalho, E.; Vala, H.; Teixeira-Lemos, E.; et al. "Serum and renal tissue markers of nephropathy in rats under immunosuppressive therapy: Cyclosporine versus sirolimus". Transplantation Proceedings 45 3 (2013): 1149-1156. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876882818&partnerID=MN8TOARS.
    10.1016/j.transproceed.2013.02.085
  71. Moura, J.; Da Silva, L.; Cruz, M.T.; Carvalho, E.. "Molecular and cellular mechanisms of bone morphogenetic proteins and activins in the skin: Potential benefits for wound healing". Archives of Dermatological Research 305 7 (2013): 557-569. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883240109&partnerID=MN8TOARS.
    10.1007/s00403-013-1381-2
  72. Moura, L.I.F.; Silva, L.; Leal, E.C.; Tellechea, A.; Cruz, M.T.; Carvalho, E.. "Neurotensin modulates the migratory and inflammatory response of macrophages under hyperglycemic conditions". BioMed Research International 2013 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84884259661&partnerID=MN8TOARS.
    10.1155/2013/941764
  73. Lopes, P.; Fuhrmann, A.; Sereno, J.; Pereira, M.J.; Nunes, P.; Pedro, J.; Melão, A.; Reis, F.; Carvalho, E.. "Effects of cyclosporine and sirolimus on insulin-stimulated glucose transport and glucose tolerance in a rat model". Transplantation Proceedings 45 3 (2013): 1142-1148. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876870991&partnerID=MN8TOARS.
    10.1016/j.transproceed.2013.02.009
  74. Tellechea, A.; Kafanas, A.; Leal, E.C.; Tecilazich, F.; Kuchibhotla, S.; Auster, M.E.; Kontoes, I.; et al. "Increased skin inflammation and blood vessel density in human and experimental diabetes". International Journal of Lower Extremity Wounds 12 1 (2013): 4-11. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875254399&partnerID=MN8TOARS.
    10.1177/1534734612474303
  75. Nunes, S.; Soares, E.; Fernandes, J.; Viana, S.; Carvalho, E.; Pereira, F.C.; Reis, F.. "Early cardiac changes in a rat model of prediabetes: Brain natriuretic peptide overexpression seems to be the best marker". Cardiovascular Diabetology 12 1 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84874618884&partnerID=MN8TOARS.
    10.1186/1475-2840-12-44
  76. Soares, E.; Prediger, R.D.; Nunes, S.; Castro, A.A.; Viana, S.D.; Lemos, C.; De Souza, C.M.; et al. "Spatial memory impairments in a prediabetic rat model". Neuroscience 250 (2013): 565-577. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882959210&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2013.07.055
  77. Pereira, M.J.; Palming, J.; Rizell, M.; Aureliano, M.; Carvalho, E.; Svensson, M.K.; Eriksson, J.W.; et al. "The immunosuppressive agents rapamycin, cyclosporin A and tacrolimus increase lipolysis, inhibit lipid storage and alter expression of genes involved in lipid metabolism in human adipose tissue". Molecular and Cellular Endocrinology 365 2 (2013): 260-269. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871359857&partnerID=MN8TOARS.
    10.1016/j.mce.2012.10.030
  78. Sereno, J.; Romão, A.M.; Parada, B.; Lopes, P.; Carvalho, E.; Teixeira, F.; Reis, F.. "Cardiorenal benefits of early versus late cyclosporine to sirolimus conversion in a rat model". Journal of Pharmacology and Pharmacotherapeutics 3 2 (2012): 143-148. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878801249&partnerID=MN8TOARS.
    10.4103/0976-500X.95513
  79. Cherian, S.; Lopaschuk, G.D.; Carvalho, E.. "Cellular cross-talk between epicardial adipose tissue and myocardium in relation to the pathogenesis of cardiovascular disease". American Journal of Physiology - Endocrinology and Metabolism 303 8 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84867609320&partnerID=MN8TOARS.
    10.1152/ajpendo.00061.2012
  80. Leal, Ermelindo C; Espinoza D; Köfalvi, Attila; Carvalho, Eugenia. "Conferenc Paper: Diabetes impairs the expression of the CB1 cannabinoid receptor, the novel homeostatic regulator of the skin.". Diabetologia 54 S1 (2011): 458-458. http://dx.doi.org/10.1007/s00125-011-2276-4.
    10.1007/s00125-011-2276-4
  81. Pedroso, D.C.S.; Tellechea, A.; Moura, L.; Fidalgo-Carvalho, I.; Duarte, J.; Carvalho, E.; Ferreira, L.. "Improved survival, vascular differentiation and wound healing potential of stem cells co-cultured with endothelial cells". PLoS ONE 6 1 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79551528768&partnerID=MN8TOARS.
    10.1371/journal.pone.0016114
  82. da Silva, L.; Neves, B.M.; Moura, L.; Cruz, M.T.; Carvalho, E.. "Neurotensin downregulates the pro-inflammatory properties of skin dendritic cells and increases epidermal growth factor expression". Biochimica et Biophysica Acta - Molecular Cell Research 1813 10 (2011): 1863-1871. http://www.scopus.com/inward/record.url?eid=2-s2.0-80051782996&partnerID=MN8TOARS.
    10.1016/j.bbamcr.2011.06.018
  83. Passadouro, M.; Metelo, A.M.; Melão, A.S.; Pedro, J.R.; Faneca, H.; Carvalho, E.; Castro, M.M.C.A.. "Study of the antidiabetic capacity of the VO(dmpp)2 complex". Journal of Inorganic Biochemistry 104 9 (2010): 987-992. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955091334&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2010.05.004
  84. Da Silva, L.; Carvalho, E.; Cruz, M.T.. "Role of neuropeptides in skin inflammation and its involvement in diabetic wound healing". Expert Opinion on Biological Therapy 10 10 (2010): 1427-1439. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956664657&partnerID=MN8TOARS.
    10.1517/14712598.2010.515207
  85. Leal, Ermelindo; Tellechea, Ana; Moura, Liane; Veves, Aristidis; Carvalho, Eugenia. "The Role of Neurotensin in Wound Healing in Diabetic and iNOS Knockout Mice". Diabetes (2010): https://publons.com/wos-op/publon/6216558/.
  86. Pereira, M.J.; Carvalho, E.; Eriksson, J.W.; Crans, D.C.; Aureliano, M.; Pereira, Maria João; Carvalho, Eugénia; Eriksson, Jan W.; Crans, Debbie C.. "Effects of decavanadate and insulin enhancing vanadium compounds on glucose uptake in isolated rat adipocytes". Journal of Inorganic Biochemistry 103 12 (2009): 1687-1692. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350566106&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2009.09.015
  87. Nunes, P.M.; Carvalho, E.; Jones, J.G.; Nunes, Patricia M.; Carvalho, Eugénia; Jones, John G.. "Elimination of glucose contamination from adipocyte glycogen extracts". Carbohydrate Research 343 9 (2008): 1486-1489. http://www.scopus.com/inward/record.url?eid=2-s2.0-44449114046&partnerID=MN8TOARS.
    10.1016/j.carres.2008.04.004
  88. Karagiannides, I.; Torres, D.; Tseng, Y.; Bowe, C.; Carvalho, E.; Espinoza, D.; Pothoulakis, C.; Kokkotou, E.. "Substance P as a Novel Anti-obesity Target". Gastroenterology 134 3 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-39749152943&partnerID=MN8TOARS.
    10.1053/j.gastro.2007.12.032
  89. Carvalho, E.; Kotani, K.; Peroni, O.D.; Kahn, B.B.. "Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle". American Journal of Physiology - Endocrinology and Metabolism 289 4 52-4 (2005): http://www.scopus.com/inward/record.url?eid=2-s2.0-23044440661&partnerID=MN8TOARS.
    10.1152/ajpendo.00116.2005
  90. Carvalho, E.; Schellhorn, S.E.; Zabolotny, J.M.; Martin, S.; Tozzo, E.; Peroni, O.D.; Houseknecht, K.L.; et al. "GLUT4 overexpression or deficiency in adipocytes of transgenic mice alters the composition of GLUT4 vesicles and the subcellular localization of GLUT4 and insulin-responsive aminopeptidase". Journal of Biological Chemistry 279 20 (2004): 21598-21605. http://www.scopus.com/inward/record.url?eid=2-s2.0-2442636649&partnerID=MN8TOARS.
    10.1074/jbc.M312269200
  91. Yang, X.; Jansson, P.-A.; Nagaev, I.; Jack, M.M.; Carvalho, E.; Sunnerhagen, K.S.; Cam, M.C.; Cushman, S.W.; Smith, U.. "Evidence of impaired adipogenesis in insulin resistance". Biochemical and Biophysical Research Communications 317 4 (2004): 1045-1051. http://www.scopus.com/inward/record.url?eid=2-s2.0-1942484345&partnerID=MN8TOARS.
    10.1016/j.bbrc.2004.03.152
  92. Jansson, P.-A.; Pellmé, F.; Hammarstedt, A.; Sandqvist, M.; Brekke, H.; Caidahl, K.; Forsberg, M.; et al. "A novel cellular marker of insulin resistance and early atherosclerosis in humans is related to impaired fat cell differentiation and low adiponectin". FASEB Journal 17 11 (2003): 1434-1440. http://www.scopus.com/inward/record.url?eid=2-s2.0-0042209622&partnerID=MN8TOARS.
    10.1096/fj.02-1132com
  93. Carvalho, E.; Jansson, P.A.; Nagaev, I.; Wenthzel, A.M.; Smith, U.. "Insulin resistance with low cellular IRS-1 expression is also associated with low GLUT4 expression and impaired insulin-stimulated glucose transport.". The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 15 6 (2001): 1101-1103. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035316142&partnerID=MN8TOARS.
  94. Carvalho, E.; Rondinone, C.; Smith, U.. "Insulin resistance in fat cells from obese Zucker rats - Evidence for an impaired activation and translocation of protein kinase B and glucose transporter 4". Molecular and Cellular Biochemistry 206 1-2 (2000): 7-16. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034055787&partnerID=MN8TOARS.
  95. Smith, U.; Carvalho, E.; Mosialou, E.; Beguinot, F.; Formisano, P.; Rondinone, C.. "PKB inhibition prevents the stimulatory effect of insulin on glucose transport and protein translocation but not the antilipolytic effect in rat adipocytes". Biochemical and Biophysical Research Communications 268 2 (2000): 315-320. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034673376&partnerID=MN8TOARS.
    10.1006/bbrc.2000.2145
  96. Carvalho, E.; Eliasson, B.; Wesslau, C.; Smith, U.. "Impaired phosphorylation and insulin-stimulated translocation to the plasma membrane of protein kinase B/Akt in adipocytes from type II diabetic subjects". Diabetologia 43 9 (2000): 1107-1115. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033811737&partnerID=MN8TOARS.
    10.1007/s001250051501
  97. Rondinone, C.M.; Carvalho, E.; Rahn, T.; Manganiello, V.C.; Degerman, E.; Smith, U.P.. "Phosphorylation of PDE3B by phosphatidylinositol 3-kinase associated with the insulin receptor". Journal of Biological Chemistry 275 14 (2000): 10093-10098. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034616384&partnerID=MN8TOARS.
    10.1074/jbc.275.14.10093
  98. Carvalho, E.; Jansson, P.-A.; Axelsen, M.; Eriksson, J.W.; Huang, X.; Groop, L.; Rondinone, C.; Sjöström, L.; Smith, U.. "Low cellular IRS 1 gene and protein expression predict insulin resistance and NIDDM". FASEB Journal 13 15 (1999): 2173-2178. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032779156&partnerID=MN8TOARS.
  99. Rondinone, C.M.; Carvalho, E.; Wesslau, C.; Smith, U.P.. "Impaired glucose transport and protein kinase B activation by insulin, but not okadaic acid, in adipocytes from subjects with Type II diabetes mellitus". Diabetologia 42 7 (1999): 819-825. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032765342&partnerID=MN8TOARS.
    10.1007/s001250051232
  100. Carvalho, E.; Aasa, R.; Göthe, P.-O.. "Electron paramagnetic resonance studies of cobalt-substituted angiotensin I-converting enzyme". Journal of Inorganic Biochemistry 62 2 (1996): 147-153. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029971610&partnerID=MN8TOARS.
    10.1016/0162-0134(95)00143-3
  101. Carvalho, E.; Gothe, P.O.; Bauer, R.; Danielsen, E.; Hemmingsen, L.. "Effect of inhibitors on the coordination geometries of cadmium at the metal sites in angiotensin-I-converting enzyme". European Journal of Biochemistry 234 3 (1995): 780-785. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029557383&partnerID=MN8TOARS.
Thesis / Dissertation
  1. Carvalho, Eugénia Maria Lourenço de. "Molecular Mechanisms of Insulin Resistance with Emphasis on IRS-1 and PKB/Akt". PhD, 2018. http://hdl.handle.net/10316/80483.
  2. Carvalho, Eugénia; Carvalho, Rui. "Mechanisms underlying peripheral resistance in a rat model of prediabetes". Master, 2015. http://hdl.handle.net/10316/31741.
  3. Carvalho, Eugénia; Palmeira, Carlos. "Molecular mechanisms involved in glucose and lipid metabolism after immunosuppressive therapy". PhD, 2014. http://hdl.handle.net/10316/25248.
  4. Veves, Aristidis; Carvalho, Eugénia; Rosete, Maria Teresa Cruz. "Cellular and molecular mechanisms of impaired wound healing in diabetes : understanding the role of substance P and mast cells". PhD, 2014. http://hdl.handle.net/10316/26466.
  5. Carvalho, Eugénia; Sousa, Hermínio C. de. "Development of novel therapeutic approaches for wound healing in diabetes". PhD, 2013. http://hdl.handle.net/10316/23741.
  6. Carvalho, Eugénia; Valverde, Angela M.. "Mechanisms of Insulin Resistance after Immunosuppressive Therapy in Brown Adipose Tissue". Master, 2013. http://hdl.handle.net/10316/24905.
  7. Pereira, Maria J.; Aureliano, M.; Carvalho, Eugénia. "Effects of immunosuppressive drugs on human adipose tissue metabolism". PhD, 2012. http://hdl.handle.net/10400.1/4916.
  8. Carvalho, Eugénia; Duarte, Carlos; Canzoniero, Lorella. "Effects of cyclosporine A and sirolimus on glucose and lipid metabolism : an in vivo rat model". Master, 2012. http://hdl.handle.net/10316/24988.
  9. Carvalho, Eugénia; Cruz, Maria Teresa; Castro, Margarida. "Neurotensin effect on skin dendritic cells and fibroblasts: repercussions in wound healing and diabetic wound healing". Master, 2010. http://hdl.handle.net/10316/28818.

Other

Other output
  1. Cyclosporine A and tacrolimus reduce the amount of GLUT4 at the cell-surface in human adipocytes: increased endocytosis as a potential mechanism for the diabetogenic effects of immunosuppressive agents. Context:Immunosuppressive agentes are associated with profound metabolic side effects including new-onset diabetes and dyslipidemia after organ transplantation. Objective: Toi nvestigated the effects of the cyclosporine A(CsA)or tacrolimus ong lucose uptake and insulin signalling in human adipocytes and their impact on the regulation of celular trafficking of the glucose transporter 4 (GLUT4). Des. 2014. Pereira, Maria João; Aureliano, M.; Palming, Jenny; Rizell, Magnus; Carvalho, Eugénia; Svensson, Maria K.; Eriksson, Jan W.; et al. http://hdl.handle.net/10400.1/4856.
    http://dx.doi.org/10.1210/jc.2014-1266
  2. Neurotensin-loaded collagen dressings reduce inflammation and improve wound healing in diabetic mice. Impaired wound healing is an important clinical problem in diabetes mellitus and results in failure to completely heal diabetic foot ulcers (DFUs), which may lead to lower extremity amputations. In the present study, collagen based dressings were prepared to be applied as support for the delivery of neurotensin (NT), a neuropeptide that acts as an inflammatory modulator in wound healing. The perfo. 2014. Moura, Liane I F; Dias, Ana M A; Suesca, Edward; Casadiegos, Sergio; Leal, Ermelindo C; Fontanilla, Marta R; Carvalho, Lina; et al. http://hdl.handle.net/10316/80404.
    10.1016/j.bbadis.2013.10.009
  3. Role of Endothelial Progenitor Cells and Inflammatory Cytokines in Healing of Diabetic Foot Ulcers. Background: To evaluate changes in endothelial progenitor cells (EPCs) and cytokines in patients with diabetic foot ulceration (DFU) in association with wound healing. Methods: We studied healthy subjects, diabetic patients not at risk of DFU, at risk of DFU and with active DFU. We prospectively followed the DFU patients over a 12-week period. We also investigated similar changes in diabetic rabbi. 2013. Tecilazich, Francesco; Dinh, Thanh; Pradhan-Nabzdyk, Leena; Leal, Ermelindo; Tellechea, Ana; Kafanas, Antonios; Gnardellis, Charalambos; et al. http://hdl.handle.net/10316/27674.
  4. mTOR inhibition with rapamycin cause impaired insulin signalling and glucose uptake in human subcutaneous and omental adipocytes. Rapamycin is an immunosuppressive agent used after organ transplantation, but its molecular effects on glucose metabolism needs further evaluation. We explored rapamycin effects on glucose uptake and insulin signalling proteins in adipocytes obtained via subcutaneous (n = 62) and omental (n = 10) fat biopsies in human donors. At therapeutic concentration (0.01 lM) rapamycin reduced basal and insul. 2012. Pereira, Maria João; Palming, Jenny; Rizell, Magnus; Aureliano, M.; Carvalho, Eugénia; Svensson, Maria K.; Eriksson, Jan W.; et al. http://hdl.handle.net/10400.1/1326.
    10.1016/j.mce.2012.01.024
  5. Improved Survival, Vascular Differentiation and Wound Healing Potential of Stem Cells Co-Cultured with Endothelial Cells. In this study, we developed a methodology to improve the survival, vascular differentiation and regenerative potential of umbilical cord blood (UCB)-derived hematopoietic stem cells (CD34+ cells), by co-culturing the stem cells in a 3D fibrin gel with CD34+-derived endothelial cells (ECs). ECs differentiated from CD34+ cells appear to have superior angiogenic properties to fully differentiated ECs. 2011. Pedroso, Dora C. S.; Tellechea, Ana; Moura, Liane; Fidalgo-Carvalho, Isabel; Duarte, João; Carvalho, Eugénia; Ferreira, Lino. http://hdl.handle.net/10316/14426.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2020 MicroRNAs - biomarkers and therapeutic targets in diabetic chronic wounds SPD2020
2019/04/14 Increased PBMC mitochondrial ATP production in obese insulin resistant children is associated with metabolic dysfunction and inflammation Keystone Symposia Conference - Immunometabolism, Metaflammation and Metabolic Disorders
Keystone Symposia (Vancouver, Canada)
2019/01/04 Boosting the wound-local immune system to modulate infection, 2nd Wound Healing Workshop, DDA; Denmark, January, 2019 Wound Healing Workshop (2nd)
Roskilde University (Roskilde, Denmark)
2018 Public Health Concerns and awareness about Diabetes in Guine-Bissau, January 2018 Public Health
Coimbra Hotel (Bissau, Guinea-Bissau)
2017/09 Endoplasmic reticulum stress and autophagy are impaired in epicardial adipose tissue from heart failure subjects. 53rd European Association for the Study of Diabetes Annual Meeting, Lisbon, Portugal, Diabetologia Supplement, September, 2017 European Association for the Study of Diabetes Annual Meeting
European Association for the Study of Diabetes (Lisbon, Portugal)
2017/07 Bioenergetics and fatty acid oxidation – how health in the young determines health in the elderly, Center for Neurosciences and Cell Biology, Coimbra, Portugal, July 2017 Center for Neurosciences and Cell Biology
Center for Neurosciences and Cell Biology (Coimbra, Portugal)
2017/05 The metabolic (molecular) phenotype of epicardial adipose tissue. European Congress on Obesity, Porto, Portugal, May 2017 European Congress on Obesity
European Congress on Obesity (Porto, Portugal)
2017 Early skin aging in diabetes is associated with a decrease in CB1 cannabinoid receptor expression. 53rd European Association for the Study of Diabetes Annual Meeting, Lisbon, Portugal, Diabetologia Supplement, September, 2017 Early skin aging in diabetes is associated with a decrease in CB1 cannabinoid receptor expression
European Association for the Study of Diabetes Annual Meeting (Lisbon, Portugal)
2017 Regulation of miRNA-146a and miR-29a during wound healing in a mouse model of type 1 diabetes. 53rd European Association for the Study of Diabetes Annual Meeting, Lisbon, Portugal, Diabetologia Supplement, September, 2017 European Association for the Study of Diabetes
European Association for the Study of Diabetes (Lisbon, Portugal)
2016/07 Diabetes and Obesity Complications in the Modern World, Institute of Biomedicine – iBiMED, Aveiro, Portugal, July 2016 iBiMED
iBiMED (Aveiro, Portugal)
2016/07 From rural Portugal to a career as a research scientist: a woman’s journey into science, Center for Neurosciences and Cell Biology, Coimbra, Portugal Center for Neurosciences and Cell Biology
Center for Neurosciences and Cell Biology (Cantanhede, Portugal)
2016/04 EAT - What do we know, UAMS College of Medicine Donald W. Reynolds Department of Geriatrics, Little Rock, AR UAMS College of Medicine Donald W. Reynolds
UAMS College of Medicine Donald W. Reynolds (Little Rock, AR, United States)
2015/04 Therapeutic targets for the treatment of wound healing in diabetes. Diabetes Wound Healing Workshop. March 30-31, 2015. Roskilde University, Denmark. Diabetes Wound Healing Workshop
Roskilde University (Roskilde, Denmark)
2015 The Role of Neuropeptides in Wound Healing in Diabetes, Geriatrics Grand Rounds, UAMS, COM, Donald W. Reynolds Department of Geriatrics, Little Rock, AR UAMS, COM, Donald W. Reynolds
UAMS, COM, Donald W. Reynolds (Little Rock, AR, United States)
2014 Molecular mechanisms of insulin resistance – the adipocyte, Division of Endocrinology and Metabolism and the UAMS Center for Osteoporosis and Metabolic Bone Diseases in the UAMS Department of Internal Medicine. Little Rock, AR UAMS Department of Internal Medicine
UAMS Department of Internal Medicine (Little Rock, AR, United States)
2014 The adipocyte and its cross-talk with other tissues, Arkansas Children’s Hospital Research Institute; Little Rock, AR Arkansas Children’s Hospital Research Institute
Arkansas Children’s Hospital Research Institute (Little Rock, Ar, United States)
2013 The fat cell as an endocrine organ – its cross talk with other tissues, University of Arkansas for Medical Sciences, Aging Center Research Seminar, Little Rock, AR University of Arkansas for Medical Sciences
University of Arkansas for Medical Sciences (Little Rock, AR, United States)
2013 Fat metabolism and immunosuppressive therapy, University of Texas Medical Branch at Galveston, TX, USA University of Texas Medical Branch at Galveston
University of Texas Medical Branch at Galveston (Galveston, TX, United States)
2013 The Role of Neuropeptides in Wound Healing in Diabetes, University of Texas Medical Branch at Galveston, USA University of Texas Medical Branch at Galveston
University of Texas Medical Branch at Galveston (Galveston, TX, United States)
2013 The adipocyte as an endocrine organ, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA The adipocyte as an endocrine organ
Beth Israel Deaconess Medical Center, Harvard Medical School, (Boston, MA, United States)
2012 Molecular mechanisms of wound healing in diabetes, Wallenberg Lab, Goteborg, Sweden Molecular mechanisms of wound healing in diabetes
Wallenberg Lab (Gothenburg, Sweden)
2011 From rural Portugal to a career as a research scientist: a woman’s journey into science, University of Minho, Braga, Portugal University of Minho
University of Minho (Braga, Portugal)
2011 Wound healing in diabetes, Instituto Investigaciones Biomedicas Alberto Sols, Madrid, Spain Instituto Investigaciones Biomedicas Alberto Sols
Instituto Investigaciones Biomedicas Alberto Sols (Madrid, Spain)
2011 Molecular Biology of the Metabolic Syndrome. CEDOC, University Nova, Lisbon, Portugal CEDOC, University Nova
CEDOC, University Nova (Lisbon, Portugal)
2010 Insulin resistance, the metabolic syndrome, Portuguese Institute of Oncology, IPO, Lisbon, Portugal Portuguese Institute of Oncology, IPO
Portuguese Institute of Oncology, IPO (Lisbon, Portugal)
2010 PTP1B regulates wound healing. Insulin Receptor Meeting, Naples, Italy Insulin Receptor Meeting
Insulin Receptor Meeting (Naples, Italy)
2010 Immunosupressive agents alter glucose metabolism and blood pressure in rats, Insulin Receptor Meeting, Naples, Italy Insulin Receptor Meeting
Insulin Receptor Meeting (Naples, Italy)
2010 Health talk: Chronic diseases, University of the Algarve, Faro, Portugal University of the Algarve
University of the Algarve (Faro)
2009 The role of neuropeptides in wound healing, University Nova de Lisbon, Portugal University Nova
University Nova (Lisbon, Portugal)
2009 Genetics, molecular biology and obesity. International Symposium of Surgery, Portugal International Symposium of Surgery
International Symposium of Surgery (Coimbra, Portugal)
2008 Substance P in wound healing. EFSD/Lilly Symposium, Bad Homburg, Germany EFSD/Lilly Symposium
EFSD/Lilly Symposium (Bad Homburg, Germany)
2008 The role of neuropeptides in wound healing. EASD Training Course, Helsinki, Finland EASD Training Course
EASD Training Course (Helsinki, Finland)
2008 The role of Substance P in wound healing. American Diabetes Association (ADA), San Francisco, USA American Diabetes Association (ADA)
American Diabetes Association (ADA) (San Francisco, United States)
2008 The role of neuropeptides in wound healing. University of Coimbra, Portugal University of Coimbra
University of Coimbra (Coimbra, Portugal)
2008 Obesity a disease of the XXI century, III Workshop in Clinical Biochemistry, Porto, Portugal III Workshop in Clinical Biochemistry
III Workshop in Clinical Biochemistry (Porto, Portugal)
2006 O adipócito: vilão ou vitima, 10th Nacional Portuguese Obesity Congress, Porto, Portugal 10th Nacional Portuguese Obesity Congress,
10th Nacional Portuguese Obesity Congress, (Porto, Portugal)
2006 The adipocyte as an endocrine organ. Fórum Internacional de Investigadores Portugueses (FIIP), Porto, Portugal Fórum Internacional de Investigadores Portugueses (FIIP)
Fórum Internacional de Investigadores Portugueses (FIIP) (Porto, Portugal)
2006 Insulin resistance: “healthy” humans and transgenic mice, University of Georgia, GA, USA University of Georgia
University of Georgia (Athens, GA, United States)
2006 The importance of the adipocyte. Novartis. Boston, MA, USA Novartis
Novartis (Boston, MA, United States)
2006 Insulin resistance in “healthy” humans and in transgenic mice - the importance of the adipocyte. Boston Biomedical Research Institute, Boston, MA, USA Boston Biomedical Research Institute
Boston Biomedical Research Institute (Boston, MA, United States)
2005 Insulin resistance a familial syndrome. Symposium on Diabetes Mellitus, Algarve, Portugal Symposium on Diabetes Mellitus
Symposium on Diabetes Mellitus (Faro, Portugal)
2005 The adipocyte as an endocrine organ. University of the Algarve, Faro, Portugal University of the Algarve,
University of the Algarve, (Faro, Portugal)
2005 The adipocyte as an endocrine organ. Tufts University, Boston, MA, USA Tufts University
Tufts University (Boston, MA, United States)
2004 Insulin resistance in “healthy” humans and in transgenic mice - the importance of the adipocyte. Synta Pharmaceuticals, Boston, MA, USA Synta Pharmaceuticals
Synta Pharmaceuticals (Boston, MA, United States)
2004 Insulin resistance in humans and in transgenic mice - the importance of the adipocyte. University of Gothenburg, Gothenburg, Sweden University of Gothenburg
University of Gothenburg (Gothenburg, Sweden)
2004 Insulin resistance in “healthy” humans and in transgenic mice - the importance of the adipocyte, AstraZeneca, Molndal, Sweden AstraZeneca
AstraZeneca (Molndal, Sweden)
2004 The adipocyte as an endocrine organ. Joslin Diabetes Center, Boston, MA, USA Joslin Diabetes Center
Joslin Diabetes Center (Boston, United States)
2001 Molecular Mechanisms of Insulin Resistance in Fat Cells. International Symposium on Insulin Receptor and Insulin Action, Geneve, Switzerland International Symposium on Insulin Receptor and Insulin Action
International Symposium on Insulin Receptor and Insulin Action (Geneve, Switzerland)
2001 Low cellular IRS-1 gene and protein expression predict insulin resistance in “healthy” humans. Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA Harvard Medical School
Harvard Medical School (Boston, MA, United States)
2001 Molecular mechanisms of insulin resistance with emphasis on IRS-1 and PKB/Akt. At the meeting of the Annual Swedish Foundation for the Study of Diabetes, Sweden, Swedish Foundation for the Study of Diabetes
Swedish Foundation for the Study of Diabetes (Gothenburg, Sweden)
1999 Impaired glucose transport by insulin, but not okadaic acid, in adipocytes from subjects with Type II diabetes mellitus. ADA, the 59th Scientific sessions, San Diego, CA, USA ADA, the 59th Scientific sessions
ADA, the 59th Scientific sessions (San Diego, CA, United States)
1993 Mechanisms of inhibition in angiotensin I-converting enzyme. FEBS International Summer School on Molecular and Cellular Biology, on Spetsai, Greece FEBS International Summer School on Molecular and Cellular Biology
FEBS International Summer School on Molecular and Cellular Biology (Spetses, Greece)
1993 One or two inhibitor-binding sites in angiotensin I-converting enzyme? INSERM (Institut National de la Santéet de la Recherche Medicale), Paris, France INSERM
INSERM (Paris, France)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2008/01/01 - 2025 She has published over 110 scientific papers, and has trained over 20 Port-doctoral fellows, over 16 PhD students and over 20 master students. She has also been able to attract funding from National and international foundations, including, H2020-MSCA-ITN-2016, the NIH, Diabetes UK, EFSD, INFARMED, HORIZON-HEALTH-2022-STAYHLTH-01-two-stage: PAS GRAS, the Camoes Institute and the FCT.
Supervisor

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022/10/01 - 2027/12/01 Creation of an Implementation Science and Health Literacy (nutrition and diabetes) advanced course at the University of Coimbra, presented online to the Doctoral Program at the Faculty of Pharmacy and the PhD program in Experimental Biology and Biomedicine, but also open to the public, since 2022. (Outros)

Scientific expedition

Activity description Institution / Organization
2022/12/01 - 2027/12/01 Field studies in Guinea-Bissau West Africa on the prevalence of diabetes, obesity and hypertension. Launching of the Guinean Annual Diabetes meeting, that started in 2023. Reached over 10 000 people with capacitation and diabetes literacy around the country, including messages through community radio in the various most spoken local languages. Working with the Civil Society to reach out to many more people, for diabetes screenings and literacy.
Distinctions

Award

2021 Expertscape's PubMed-based algorithms place you in the top 1% of scholars writing about Foot Ulcers over the past 10 years, a level we label as "Expert."

Title

2024 Committee member - Innovation Fund Denmark

Other distinction

2019 Senior Editor for Journal of Endocrinology and Journal of Molecular Endocrinology
2019 Board Member of the European Tissue Repair Society (ETRS)
2012 AD HOC International Grant Reviewer
2001 Post-Doctoral Training
2000 AD HOC Reviewer for scientific journals (over 35 Journal)
1999 Professional memberships