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Maria de La Salete de Jesus Baptista completed her Integrated MSc in Pharmaceutical Sciences in 2011 by Universidade de Coimbra and her PhD in Pharmaceutical Sciences in 2018 by Faculty of Pharmacy of University of Coimbra. She is a contracted Researcher in Centro de Ciências e Tecnologias Nucleares, Instituto Superior Técnico. She published 3 articles in journals. She has 2 section(s) of books. She has received 2 awards and/or honors. She participates and/or participated as Researcher in 1 project(s). She works in the area(s) of Medical and Health Sciences, Chemical Sciences, and Computer and Information Sciences with emphasis on Bioinformatics.
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Identification

Personal identification

Full name
Maria de La Salete de Jesus Baptista

Citation names

  • Baptista, Salete J.

Author identifiers

Ciência ID
5D1C-C0C2-747A

Email addresses

  • salete.baptista@ctn.tecnico.ulisboa.pt (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Health Sciences
  • Exact Sciences - Chemical Sciences
  • Exact Sciences - Computer and Information Sciences
  • Exact Sciences - Computer and Information Sciences - Bioinformatics

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Italian Intermediate (B1) Intermediate (B1) Elementary (A2) Advanced (C1)
Education
Degree Classification
2019/12/18 - 2019/12/19
Attended
 HADDOCK workshop on Integrative Modelling of Biomolecular Complexes (Outros)
Universidade de Coimbra, Portugal
2011/09 - 2018/06/12
Concluded
 Doutoramento em Ciências Farmacêuticas (Doutoramento)
Major in Química Farmacêutica
Universidade de Coimbra Faculdade de Farmácia, Portugal
 Aprovada com Distinção e Louvor
2017
Concluded
 First Certificate in English (FCE) (Outros)
University of Cambridge, United Kingdom
2016 - 2016
Concluded
 2016 Summer School in Computational Biology – from molecules to tissues (Outros)
Universidade de Coimbra, Portugal
2013 - 2013
Concluded
 Beyond the Microscope, Culturing Life: Cell Culture and Tissue Course (Outros)
Centre of Investigation on Environment, Genetics and Oncobiology, Portugal
2013 - 2013
Concluded
 Oncobiology (Outros)
Center for Neuroscience and Cell Biology, Portugal
2012 - 2012
Concluded
 Structure and Dynamics of Biological Macromolecules (Outros)
Federation of European Biochemical Societies , Bulgaria
2006 - 2011
Concluded
 Mestrado Integrado em Ciências Farmacêuticas (Mestrado)
Universidade de Coimbra, Portugal
"Acompanhamento Farmacoterapêutico de um doente na Farmácia Luciano e Matos" (THESIS/DISSERTATION)
 16
Affiliation

Science

Category
Host institution 		Employer
2019/04 - Current Contracted Researcher (Research) Centro de Ciências e Tecnologias Nucleares, Portugal
Centro de Ciências e Tecnologias Nucleares, Portugal
2017/03 - 2019/03 Researcher (Research) CHEM4PHARMA, Portugal
2011/09 - 2018/06 Researcher (Research) Universidade de Coimbra, Portugal
Universidade de Coimbra Faculdade de Farmácia, Portugal
2012/02 - 2013/06 Visiting Researcher (Research) Consiglio Nazionale delle Ricerche Area della ricerca di Milano, Italy
Consiglio Nazionale delle Ricerche Area della ricerca di Milano, Italy
Projects

Contract

Designation Funders
2019/04/03 - Current MEMBRANEPROT
MEMBRANEPROT - PTDC/QUI-OUT/32243/2017 - IST-ID
Researcher
Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2017/03/15 - 2019/03/14 Drug2CAD
(CENTRO- 01-0247-FEDER-003269)
Concluded
Outputs

Publications

Book chapter
  1. Barreto, Carlos A.V.; Baptista, Salete J.; Bueschbell, Beatriz; Magalhães, Pedro; Preto, A.J.; Lemos, Agostinho; Rosário-Ferreira, Nicia; et al. "Arrestin and G protein interactions with GPCRs: a structural perspective". In GPCRs as Therapeutic Targets. Wiley and Sons, 2021.
    In press
  2. Preto, A.J.; Marques, Ana Catarina; Baptista, Salete J.; Bueschbell, Beatriz; Barreto, Carlos A.V.;; Gaspar, Ana Teresa; Pinheiro, Ian. "Targeting GPCRs via Multi-platforms arrays and AI. In Comprehensive Pharmacology". 2021.
    In press
  3. Barreto, Carlos A.V.; Baptista, Salete J.; Preto, António José; Matos-Filipe, Pedro; Mourão, Joana; Melo, Rita; Moreira, Irina. "Prediction and targeting of GPCR oligomer interfaces". In Oligomerization in Health and Disease: From Enzymes to G Protein-Coupled Receptors, 105-149. Elsevier, 2020.
    10.1016/bs.pmbts.2019.11.007
  4. Baptista, Salete J.; Silva, Maria M. C.; Salvador, Jorge A. R.. "PARP-1 Mediated DNA Repair and its Inhibition by Small Molecules". In PARP-1 Mediated DNA Repair and its Inhibition by Small Molecules, 2-44. India: Avid Science, 2017.
    Published
Conference poster
  1. Coimbra, Judite R. M.; Baptista, Salete J.; Santos, Armanda E.; Moreira, Paula Isabel; Silva, Maria M.C; Dinis, Teresa C. P.; Jorge A. R. Salvador. "APPLICATION OF COMPUTATIONAL METHODS FOR DISCOVERY OF NOVEL BACE1 INHIBITORS: LIGAND- AND STRUCTURE-BASED PROTOCOLS WITH IN VITRO EVALUATION". Paper presented in 13th National Organic Chemistry Meeting & 6th National Medicinal Chemistry Meeting, January 15 - 17, 2020, Aveiro, Portugal, 2020.
  2. Coimbra, Judite R. M.; Baptista, Salete J.; Santos, Armanda E; Moreira, Paula Isabel; Silva, Maria M.C; Dinis, Teresa C.P; Salvador, Jorge A. R.. "TARGETING ALZHEIMER’S DISEASE: A VIRTUAL SCREENING PROTOCOL TO DISCOVER NEW CENTRAL-ACTING BACE1 INHIBITORS". Paper presented in Spring 2019 ACS National Meeting & Expo, Chemistry for New Frontiers, March 31 - April 4, 2019, Orlando, FL, USA, 2019.
  3. Coimbra, Judite R. M.; Baptista, Salete J.; Santos, Armanda E.; Moreira, Paula Isabel; Silva, Maria M. C.; Dinis, Teresa C.P; Salvador, Jorge A. R.. "TARGETING ALZHEIMER’S DISEASE: AN INTEGRATED PROTOCOL OF VIRTUAL SCREENING FOR DISCOVERY OF NOVEL ANTI-BACE1 AGENTS". Paper presented in 14th International Conference on Alzheimer's and Parkinson's Diseases and related neurological disorders, March 26-31, 2019, Lisbon, Portugal, 2019.
  4. Coimbra, Judite R. M.; Baptista, Salete J.; Santos, Armanda E.; Silva, Maria M.C; Dinis, Teresa C. P.; Salvador, Jorge A. R.. "IDENTIFICATION OF NOVEL BACE1 INHIBITORS: A COMBINED PROTOCOL OF PHARMACOPHORE MODELING, VIRTUAL SCREENING AND STRUCTURE-BASED DRUG DESIGN". Paper presented in Presented at the XXV EFMC International Symposium on Medicinal Chemistry, September 2-6, 2018, Ljubljana, Slovenia, 2018.
  5. Baptista, Salete J.; Coimbra, Judite R. M.; Moroni, Elisabetta; Meli, Massimiliano; Colombo, Giorgio; Dinis, Teresa C.P; Silva, Maria M. C.; Salvador, Jorge A. R.. "Novel PARP-1 Inhibitor Scaffolds: A Dynamic-Based Pharmacophore Approach". Paper presented in 12TH NATIONAL ORGANIC CHEMISTRY MEETING (12ENQO) AND THE 5TH NATIONAL MEDICINAL CHEMISTRY MEETING (5ENQT), 2018.
  6. Coimbra, Judite R. M.; Baptista, Salete J.; Santos, Armanda E.; Silva, Maria M. C.; Dinis, Teresa C. P.; Salvador, Jorge A. R.. "NEW BACE I INHIBITORS: A STRUCTURE-BASED AND LIGAND-BASED RATIONAL DRUG DESIGN. PHARMACOPHORE MODELING AND VIRTUAL SCREENING". Paper presented in 12th National Organic Chemistry Meeting & 5th National Medicinal Chemistry Meeting, 2018.
  7. Brito, Hugo; Baptista, Salete J.; Silva, Maria M. C.; Salvador, Jorge A. R.; Castro, Rui E.; Rodrigues, Cecília M.P.. "Targeting of distinct FXRa isoforms by novel bile acid derivatives prevents lipotoxicity in liver cells". Paper presented in EASL HCC SUMMIT 2017, 2017.
  8. Baptista, Salete J.; Silva, Maria M. C.; Salvador, Jorge A. R.; Moroni, Elisabetta; Colombo, Giorgio. "New PARP-1 Inhibitors: A structure-based drug design. Pharmacophore modelling and virtual screening". Paper presented in FMC – Frontiers in Medicinal Chemistry, 2015.
  9. Baptista, Salete J.; Silva, Maria M. C.; Salvador, Jorge A. R.; Moroni, Elisabetta; Colombo, Giorgio. "Molecular dynamics and pharmacophore modelling studies aiming the discovery of novel PARP-1 inhibitors". Paper presented in Encontro de Jovens Investigadores de Biologia Computacional Estrutural 2015, 2015.
  10. Salvador, Jorge A. R.; Baptista, Salete J.; Figueiredo, Sandra A.C.; Gonçalves, Bruno M.F.; Alho, Daniela; Leal, Ana S.; Mendes, Vanessa I.S.; Valdeira, Ana S. Leal. "Green Pharmaceutical Chemistry & Drug Discovery". Paper presented in Hovione & MIT Portugal Symposium: Showcasing Portuguese Pharma Science, 2014.
  11. Baptista, Salete J.; Silva, Maria M. C.; Salvador, Jorge A. R.; Moroni, Elisabetta; Colombo, Giorgio. "“New insights into the PARP-1 molecular structure. Molecular Dynamics and Pharmacophore Modeling studies aiming the discovery of novel anticancer agents". Paper presented in 20th EuroQSAR Understanding Chemical-Biological Interactions, 2014.
  12. Baptista, Salete J.; Silva, Maria M. C.; Salvador, Jorge A. R.; Moroni, Elisabetta; Colombo, Giorgio. "Struture-Based Drug Design. New PARP-1 Inhibitors: In Silico Screening and Molecular Dynamics Studies". Paper presented in EFMC – International Symposium on Medicinal Chemistry, 2014.
  13. Baptista, Salete J.; Colombo, Giorgio; Salvador, Jorge A. R.; Silva, Maria M. C.; Dinis, Teresa C. P.. "Exploring PARP-1 molecular structure. New insights from molecular modeling studies aiming the discovery of novel anticancer agents". Paper presented in 3rd Portuguese Meeting on Medicinal Chemistry, 2012.
  14. Silva, Maria M. C.; Neves, Marco; Baptista, Salete J.; Sá e Melo, M. Luísa; Ferrandi, Erica; Monti, Daniela; Riva, Sergio. "Bile acid derivates as ligands of FXR and PXR receptors: in silico screening and chemoenzymatic synthesis". Paper presented in 2nd Portuguese Meeting on Medicinal Chemistry, 2010.
Journal article
  1. Silva, Rúben D. M.; Franco Machado, João; Gonçalves, Kyle; Lucas, Francisco M.; Batista, Salete; Melo, Rita; Morais, Tânia S.; Correia, João D. G.. "Ultrasonication Improves Solid Phase Synthesis of Peptides Specific for Fibroblast Growth Factor Receptor and for the Protein-Protein Interface RANK-TRAF6". Molecules 26 23 (2021): 7349. http://dx.doi.org/10.3390/molecules26237349.
    10.3390/molecules26237349
  2. Rosário-Ferreira, Nícia; Baptista, Salete J.; Barreto, Carlos A. V.; Rodrigues, Filipe E. P.; Silva, Tomás F. D.; Ferreira, Sara G. F.; Vitorino, João N. M.; et al. "In Silico End-to-End Protein–Ligand Interaction Characterization Pipeline: The Case of SARS-CoV-2". ACS Synthetic Biology 10 11 (2021): 3209-3235. http://dx.doi.org/10.1021/acssynbio.1c00368.
    10.1021/acssynbio.1c00368
  3. Borges, Pedro H.O.; Pedreiro, Sónia; Baptista, Salete J.; Geraldes, Carlos F.G.C.; Batista, M.T.; Silva, Maria M.C.; Figueirinha, Artur. "Inhibition of a-glucosidase by flavonoids of Cymbopogon citratus (DC) Stapf". Journal of Ethnopharmacology 280 (2021): 114470. http://dx.doi.org/10.1016/j.jep.2021.114470.
    10.1016/j.jep.2021.114470
  4. Barreto, Carlos A. V.; Baptista, Salete J.; Preto, António J.; Silvério, Daniel; Melo, Rita; Moreira, Irina S.. "Decoding Partner Specificity of Opioid Receptor Family". Frontiers in Molecular Biosciences 8 (2021): http://dx.doi.org/10.3389/fmolb.2021.715215.
    10.3389/fmolb.2021.715215
  5. Preto, A. J.; Barreto, Carlos A. V.; Baptista, Salete J.; Almeida, José Guilherme de; Lemos, Agostinho; Melo, André; Cordeiro, M. Nátalia D. S.; et al. "Understanding the Binding Specificity of G-Protein Coupled Receptors toward G-Proteins and Arrestins: Application to the Dopamine Receptor Family". Journal of Chemical Information and Modeling 60 8 (2020): 3969-3984. http://dx.doi.org/10.1021/acs.jcim.0c00371.
    10.1021/acs.jcim.0c00371
  6. Resende, Rosa; Ferreira-Marques, Marisa; Moreira, Patrícia; Coimbra, Judite R.M.; Baptista, Salete J.; Isidoro, Ciro; Salvador, Jorge A.R.; et al. "New BACE1 Chimeric Peptide Inhibitors Selectively Prevent AßPPß Cleavage Decreasing Amyloid-ß Production and Accumulation in Alzheimer’s Disease Models". Journal of Alzheimer's Disease (2020): 1-21. http://dx.doi.org/10.3233/jad-200381.
    Published • 10.3233/jad-200381
  7. Coimbra, Judite R. M.; Baptista, Salete J.; Dinis, Teresa C. P.; Silva, Maria M. C.; Moreira, Paula I.; Santos, Armanda E.; Salvador, Jorge A. R.. "Combining Virtual Screening Protocol and In Vitro Evaluation towards the Discovery of BACE1 Inhibitors". Biomolecules 10 4 (2020): 535. http://dx.doi.org/10.3390/biom10040535.
    10.3390/biom10040535
  8. Coimbra, Judite R. M.; Marques, Daniela F. F.; Baptista, Salete J.; Pereira, Cláudia M. F.; Moreira, Paula I.; Dinis, Teresa C. P.; Santos, Armanda E.; Salvador, Jorge A. R.. "Highlights in BACE1 Inhibitors for Alzheimer's Disease Treatment". Frontiers in Chemistry 6 (2018): http://dx.doi.org/10.3389/fchem.2018.00178.
    10.3389/fchem.2018.00178
  9. Baptista, Salete J.; Silva, Maria M. C.; Moroni, Elisabetta; Meli, Massimiliano; Colombo, Giorgio; Dinis, Teresa C. P.; Salvador, Jorge A. R.. "Novel PARP-1 Inhibitor Scaffolds Disclosed by a Dynamic Structure-Based Pharmacophore Approach". PLOS ONE 12 1 (2017): e0170846-e0170846.
    Published • 10.1371/journal.pone.0170846

Other

Spin-off company
  1. 2015. CHEM4PHARMA. The development of innovative treatments for Cancer and Alzheimer's Diseases.. https://www.chem4pharma.com.
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2019/09 - Current Modulating the circadian rhythm through nuclear receptors ligands. A rational drug discovery approach.
Co-supervisor
 PhD in Pharmaceutical Sciences (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2020/01/15 Design of a Multitarget Strategy for Proteasome and HDAC Inhibition
(Thesis) Main arguer
 Pedro de Sousa Monteiro (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017/07/17 Resistência aos Inibidores do Proteassoma: uma estratégia in silico
(Thesis) Main arguer
 Carlota Miguel Leonardo (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Association member

Society Organization name Role
2017 - Current Sociedade Portuguesa de Química
2011 - Current Ordem dos Farmacêuticos

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2020/09/08 - 2020/09/10 Introduction to structural biology: Molecular docking using HADDOCK software - Laboratory Sessions at 1st Summer School of C2TN (CARISMA) (Curso de Especialização Tecnológica) Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2019/03/15 - 2019/03/15 Identificação de novos modeladores enzimáticos através de métodos computacionais - Química Farmacêutica II Mestrado Integrado em Ciências Farmacêuticas (Mestrado integrado) Universidade de Coimbra Faculdade de Farmácia, Portugal
2019/02 - 2019/02 Computer-aided drug design: a tool for discovery new drugs - Protein engineering and drug development: From concepts to applications PhD Programme in Experimental Biology and Biomedicine Universidade de Coimbra, Portugal
Distinctions

Other distinction

2011 Bolsa de Doutoramento SFRH/BD/80975/2011
Fundação para a Ciência e a Tecnologia - Ministério da Educação e Ciência, Portugal
2010 Prémio anual: 3% dos Melhores Estudantes
Universidade de Coimbra, Portugal