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Biologist with Emphasis on Genetics from Universidad del Valle (Colombia), carried out master and PhD studies at the Laboratory of Genome Structure and Function at Tokyo Institute of Technology in Japan, and a Doctoral internship at The Japanese Foundation for Cancer Research. In 2013 receives the International Fellowship for Women in Science from UNESCO and L’Oreal Foundation, with which conducted postdoc studies at the Laboratory of Chromosome Biology at Instituto Gulbenkian de Ciência and at the Laboratory of Disease Transcriptomics at Instituto de Medicina Molecular João Lobo Antunes in Portugal. In 2017 is selected as finalist for the Innovation Boot Camp: RNA Splicing in Cancer organized by BioMed X Institute in Heidelberg, Germany, and invited to participate in a 4-year funded research team sponsored by the pharmaceutical Merck. Currently continue her association to BioMed X, Merck and iMM as consultant bioinformatics researcher. Lina Marcela Gallego-Paez published 5 articles in peer-reviewed journals, one review for the Encyclopedia of Life Sciences and three online computational resources in the field of cancer transcriptomics.
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Identification

Personal identification

Full name
Lina Marcela Gallego Páez

Citation names

  • Páez, Lina
  • Lina Marcela Gallego-Paez

Author identifiers

Ciência ID
5C1E-0C03-E7F4
ORCID iD
0000-0003-0255-8131

Email addresses

  • lina.paez@nms.unl.pt (Professional)

Telephones

Telephone
  • 218 803 00 Ext.: 26058 (Professional)

Addresses

  • Campo dos Mártires da Pátria 130, 1169-056, Lisboa, Lisboa, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Molecular Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Spanish; Castilian (Mother tongue)
Portuguese Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
German Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2)
Japanese Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2)
Education
Degree Classification
2014/06/01 - 2015/12/15
Concluded
 Environmental, Medical and Scientific Communication (Master Universitario)
Major in Science Communication
Universitat Pompeu Fabra, Spain
 Do not apply (studies abroad)
2009/04/01 - 2014/03/26
Concluded
 Biological Sciences (Doctor of Philosophy)
Major in Genome Structure And Function - Tokyo Institute of Technology
Tokyo Kogyo Daigaku - Suzukakedai Gakuen, Japan
"Functional analysis of Smc5/6 Complex in Human cells" (THESIS/DISSERTATION)
 Do not apply (studies abroad)
2007/10/01 - 2009/03/31
Concluded
 Biological Sciences (Master)
Major in Genome Structure And Function - Tokyo Institute of Technology
Tokyo Kogyo Daigaku - Suzukakedai Gakuen, Japan
"Chromosomal localization of the condensin complex in Drosophila melanogaster" (THESIS/DISSERTATION)
 Do not apply (studies abroad)
2006/02/18 - 2006/08/19
Concluded
 University Pedagogy (Postgraduate Certificate)
Universidad Libre - Campus Cali, Colombia
 Do not apply (studies abroad)
2000/08/01 - 2005/12/15
Concluded
 Biologia (Bachelor)
Major in Genética
Universidad del Valle, Colombia
"Frequency of microdeletions in the long arm of Y-chromosome in idiopathic oligozoospermia and azoospermia patients in South-West Colombia" (THESIS/DISSERTATION)
 Do not apply (studies abroad)
Affiliation

Science

Category
Host institution 		Employer
2023/03/01 - Current Science and Technology Management Universidade NOVA de Lisboa NOVA Medical School, Portugal
Universidade NOVA de Lisboa NOVA Medical School, Portugal
2022/03/01 - 2023/02/28 Contracted Researcher (Research) BioMed X GmbH, Germany
BioMed X GmbH, Germany
2022/02/01 - 2023/02/28 Contracted Researcher (Research) Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2022/01/03 - 2023/01/31 Contracted Researcher (Research) Merck KGaA, Germany
Merck KGaA, Germany
2018/04/01 - 2021/11/26 Contracted Researcher (Research) BioMed X GmbH, Germany
BioMed X GmbH, Germany
2015/06/15 - 2018/03/20 Postdoc (Research) Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2014/04/01 - 2015/05/31 Postdoc (Research) Instituto Gulbenkian de Ciência, Portugal
Instituto Gulbenkian de Ciência, Portugal
2013/04/01 - 2014/03/31 Research Assistant (Research) Ganken Ariake Byoin Masuika, Japan
Ganken Ariake Byoin Masuika, Japan
2012/04/01 - 2013/03/31 Research Assistant (Research) Tokyo Daigaku, Japan
Tokyo Daigaku, Japan
Outputs

Publications

Journal article
  1. Esperança-Martins, Miguel; Melo-Alvim, Cecília; Dâmaso, Sara; Lopes-Brás, Raquel; Peniche, Tânia; Nogueira-Costa, Gonçalo; Abreu, Catarina; et al. "Breast Sarcomas, Phyllodes Tumors, and Desmoid Tumors: Turning the Magnifying Glass on Rare and Aggressive Entities". Cancers 15 15 (2023): 3933. http://dx.doi.org/10.3390/cancers15153933.
    Published • 10.3390/cancers15153933
  2. Gomes, Inês; Gallego-Paez, Lina M.; Jiménez, Maria; Santamaria, Patricia G.; Mansinho, André; Sousa, Rita; Abreu, Catarina; et al. "Co-targeting RANK pathway treats and prevents acquired resistance to CDK4/6 inhibitors in luminal breast cancer". Cell Reports Medicine 4 8 (2023): 101120. http://dx.doi.org/10.1016/j.xcrm.2023.101120.
    10.1016/j.xcrm.2023.101120
  3. Lina M. Gallego-Paez; William J.S. Edwards; Manasa Chanduri; Yanyu Guo; Thijs Koorman; Chieh-Yu Lee; Nina Grexa; et al. "TLN1 contains a cancer-associated cassette exon that alters talin-1 mechanosensitivity". Journal of Cell Biology (2023): https://doi.org/10.1083/jcb.202209010.
    10.1083/jcb.202209010
  4. Raquel Lopes-Brás; Dolores Lopez-Presa; Miguel Esperança-Martins; Cecília Melo-Alvim; Lina Gallego; Luís Costa; Isabel Fernandes. "Genomic Profiling of Sarcomas: A Promising Weapon in the Therapeutic Arsenal". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms232214227.
    10.3390/ijms232214227
  5. Lina M. Gallego-Paez; Jan Mauer. Corresponding author: Lina M. Gallego-Paez. "DJExpress: An integrated application for differential splicing analysis and visualization". Frontiers in Bioinformatics (2022): https://www.frontiersin.org/articles/10.3389/fbinf.2022.786898/full.
    Published
  6. Raquel Cruz-Duarte; Catia Rebelo de Almeida; Magda Negrao; Afonso Fernandes; Paula Borralho; Daniel Sobral; Lina M. Gallego-Paez; et al. Corresponding author: Marta Martins. "Predictive and Therapeutic Implications of a Novel PLCg1/SHP2-Driven Mechanism of Cetuximab Resistance in Metastatic Colorectal Cancer". CLINICAL CANCER RESEARCH | TRANSLATIONAL CANCER MECHANISMS AND THERAPY (2021):
    Open access • Published
  7. Gallego-Paez LM; Bordone MC; Leote AC; Saraiva-Agostinho N; Ascensão-Ferreira M; Barbosa-Morais NL. "Alternative splicing: the pledge, the turn, and the prestige : The key role of alternative splicing in human biological systems.". (2017): http://europepmc.org/abstract/med/28374191.
    10.1007/s00439-017-1790-y
  8. Sreerama Chaitanya Sridhara; Sílvia Carvalho; Ana Rita Grosso; Lina Marcela Gallego-Paez; Maria Carmo-Fonseca; Sérgio Fernandes de Almeida. "Transcription Dynamics Prevent RNA-Mediated Genomic Instability through SRPK2-Dependent DDX23 Phosphorylation". Cell Reports 18 2 (2017): 334-343. https://doi.org/10.1016%2Fj.celrep.2016.12.050.
    10.1016/j.celrep.2016.12.050
  9. Gallego-Paez LM; Tanaka H; Bando M; Takahashi M; Nozaki N; Nakato R; Shirahige K; Hirota T. "Smc5/6-mediated regulation of replication progression contributes to chromosome assembly during mitosis in human cells.". (2014): http://europepmc.org/abstract/med/24258023.
    10.1091/mbc.e13-01-0020
Online resource
  1. Lina Marcela Gallego-Paez; Jan Mauer. Corresponding author: Lina Marcela Gallego-Paez. DJExpress R package. 2021. https://github.com/MauerLab/DJExpress.
  2. Lina Marcela Gallego-Paez; Jan Mauer. Corresponding author: Lina Marcela Gallego-Paez. DJEC DB. 2021. https://gitlab.com/mauerlabrsc/djecdb.
  3. Saraiva-Agostinho, Nuno; Nuno Luís Barbosa-Morais; André Falcão; Lina Marcela Gallego-Paez; Marie Bordone; Teresa Maia; Mariana Ferreira; Ana Carolina Leote; Bernardo de Almeida. Corresponding author: Saraiva-Agostinho, Nuno. psichomics: graphical Interface for Alternative Splicing Quantification, Analysis and Visualisation. 2018. https://bioconductor.org/packages/release/bioc/html/psichomics.html.

Other

Other output
  1. Mitosis and Meiosis: Molecular Control of Chromosome Separation. 2001. Kota Nagasaka; Lina M Gallego-Paez; Toru Hirota. http://dx.doi.org/10.1002/9780470015902.a0005917.pub2.
    10.1002/9780470015902.a0005917.pub2
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2021 - 2021 Functional characterization of cancer splicing aberrations
Co-supervisor
 Master program in Molecular Biosciences (Master)
Universität Heidelberg Zentrum für Molekulare Biologie, Germany

BioMed X GmbH, Germany
2018 - 2021 Pharmacological inhibition of RNA splicing promotes presentation of cryptic neoepitopes
Co-supervisor
BioMed X GmbH, Germany

Universität Heidelberg Zentrum für Molekulare Biologie, Germany
2019/09/16 - 2020/01/31 Reporter model to investigate mTORC1-mediated translation of the mis-spliced ribosomal protein isoforms
Co-supervisor
 Internship for the Master program in Molecular Biosciences (Scientific initiation)
Universität Heidelberg Zentrum für Molekulare Biologie, Germany

BioMed X GmbH, Germany
2017 - 2018 Alternative Splicing of EXOC7 in Colorectal Cancer Development
Co-supervisor
 Mestrado em Genética Molecular e Biomedicina (Master)
Faculdade de Ciência e Tecnologias da Universidade Nova de Lisboa, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2017/01/16 - 2017/01/16 Gender Balance in Science Debate: Inside research, around researchers (2017/01/16 - 2017/01/16)
Round table (Member of the Organising Committee)
 Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2015/11/26 - 2015/11/26 Talk on Biotech Research in Japan and Europe at "Heroes Fest 2015". This is the most important festival of entrepreneurship and innovation in Colombia, organised by the Ministry of Commerce, Industry and Tourism.
Festival
 Heroes Fest
Colombian Ministry of Commerce, Industry and Tourism., Colombia

Interview (tv / radio show)

Program Topic
2021/01/30 - 2021/01/30 Interview for the podcast: Success Across Boundaries . The podcast features stories of expats who have successfully worked up the ladder while navigating foreign countries and systems. Their success stories serve as the learning for those who aspire to become global citizens. Women in STEM
Distinctions

Award

2013 UNESCO-L'Oreal International Fellowship “For Women in Science”
United Nations Educational Scientific and Cultural Organization, France

Fondation L'Oréal, France
2012 Dean's Poster Award at The Research Achievements of GCOE (Global Center of Excellence) Program
Tokyo Daigaku, Japan
2011 Best Oral Presentation at the Annual Meeting of the Institute of Molecular and Cellular Biosciences
Tokyo Daigaku, Japan
2011 Prize for the PLOS Genetics Young Scientist Prize for Best Poster Presentation at the 18th International Chromosome Conference
The University of Manchester, United Kingdom
2008 DCW Award for outstanding results at the “Directed Collaboration Works” Course, Graduate School of Bioscience and Biotechnology
Tokyo Kogyo Daigaku - Suzukakedai Gakuen, Japan
2007 National Prize of Genetics and Biotechnology, for the research “Factores Genéticos Asociados a Infertilidad Masculina: Microdeleciones del Cromosoma Y, Mutación F508 (Genetic factors associated to Male Infertility: Microdeletions on the Y-Chromosome and F
Asociación Colombiana de Ciencias Biológicas, Colombia

Other distinction

2017 Selected Candidate from the Innovation boot camp: RNA Splicing in Cancer
BioMed X GmbH, Germany

Merck KGaA, Germany