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Identification

Personal identification

Full name
Ana Luísa Mendanha Falcão

Citation names

  • Falcão, Ana Mendanha
  • Falcao, AM

Author identifiers

Ciência ID
5C17-ECE9-7401
ORCID iD
0000-0003-4356-5936

Email addresses

  • amfalcao@med.uminho.pt (Professional)

Telephones

Telephone
  • 253604875 (Professional)

Addresses

  • Life and Health Sciences Research Institute (ICVS) University of Minho, 4710-057 , Campus Gualtar , Braga, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2013/03/01 - 2019/04/30
Concluded
 Neurobiology of disease (Pós-doutoramento)
Karolinska Institutet Department of Medical Biochemistry and Biophysics, Sweden
2009/01/01 - 2012/12/07
Concluded
 Medical and Health Sciences (Doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
"Novel perspectives on the subependymal zone complexity and modulation" (THESIS/DISSERTATION)
 n/a
2002/09 - 2007/07
Concluded
 Bioquímica (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"n/a" (THESIS/DISSERTATION)
 16
Affiliation

Science

Category
Host institution 		Employer
2019/07/15 - Current Research Assistant (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2013/03/01 - 2019/04 Postdoc (Research) Karolinska Institutet Department of Medical Biochemistry and Biophysics, Sweden
Karolinska Institutet Department of Medical Biochemistry and Biophysics, Sweden

Others

Category
Host institution 		Employer
2009/01/01 - 2013/02/01 PhD student Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2006/07/26 - 2007/07/16 Research training for graduation Universidade de Coimbra, Portugal
Karolinska Institutet Institutionen för Neurovetenskap, Sweden
Outputs

Publications

Book chapter
  1. Bannister, A.J.; Falcão, A.M.; Castelo-Branco, G.. "Histone Modifications and Histone Variants in Pluripotency and Differentiation". 35-64. 2017.
Conference poster
  1. Lourenço, Tânia; Gerardo, Heloísa; Falcão, Ana Mendanha; Castelo-Branco, Gonçalo; Grãos, Mário. "The role of PADI2 on oligodendrocyte differentiation enhanced by mechanotransduction". Paper presented in V Symposium of the Portuguese Glial Network, 2021.
Journal article
  1. Vikhe Patil, Kim; Meijer, Mandy; Mak, Kylie Hin-Man; Yang, Wei; Falcão, Ana Mendanha; Castelo-Branco, Gonçalo; Genander, Maria. "Co-expression of PADI isoforms during progenitor differentiation enables functional diversity". Philosophical Transactions of the Royal Society B: Biological Sciences 378 1890 (2023): http://dx.doi.org/10.1098/rstb.2022.0451.
    10.1098/rstb.2022.0451
  2. Meijer, Mandy; Agirre, Eneritz; Kabbe, Mukund; van Tuijn, Cassandra A.; Heskol, Abeer; Zheng, Chao; Mendanha Falcão, Ana; et al. "Epigenomic priming of immune genes implicates oligodendroglia in multiple sclerosis susceptibility". Neuron (2022): http://dx.doi.org/10.1016/j.neuron.2021.12.034.
    10.1016/j.neuron.2021.12.034
  3. Loureiro-Campos, Eduardo; Pinto, Luísa; Mendanha Falcão, Ana. "CSF circulation regulates depression: do not disturb the flow!". Molecular Psychiatry (2021): http://dx.doi.org/10.1038/s41380-021-01323-7.
    10.1038/s41380-021-01323-7
  4. Carlström, Karl E.; Zhu, Keying; Ewing, Ewoud; Krabbendam, Inge E.; Harris, Robert A.; Falcão, Ana Mendanha; Jagodic, Maja; Castelo-Branco, Gonçalo; Piehl, Fredrik. "Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis". Nature Communications 11 1 (2020): http://dx.doi.org/10.1038/s41467-020-17871-5.
    10.1038/s41467-020-17871-5
  5. Domingues, Helena S.; Falcão, Ana Mendanha; Mendes-Pinto, Inês; Salgado, António J.; Teixeira, Fábio G.. "Exosome Circuitry During (De)(Re)Myelination of the Central Nervous System". Frontiers in Cell and Developmental Biology 8 (2020): http://dx.doi.org/10.3389/fcell.2020.00483.
    10.3389/fcell.2020.00483
  6. Jäkel, Sarah; Agirre, Eneritz; Mendanha Falcão, Ana; van Bruggen, David; Lee, Ka Wai; Knuesel, Irene; Malhotra, Dheeraj; et al. "Altered human oligodendrocyte heterogeneity in multiple sclerosis". Nature 566 7745 (2019): 543-547. http://dx.doi.org/10.1038/s41586-019-0903-2.
    10.1038/s41586-019-0903-2
  7. Falcão, A.M.; Meijer, M.; Scaglione, A.; Rinwa, P.; Agirre, E.; Liang, J.; Larsen, S.C.; et al. "PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination". Cell Reports 27 4 (2019): 1090-1102.e10. http://www.scopus.com/inward/record.url?eid=2-s2.0-85064315917&partnerID=MN8TOARS.
    Published • 10.1016/j.celrep.2019.03.108
  8. Novais, Ashley; Silva, Alberto; Ferreira, Ana Catarina; Falcão, Ana Mendanha; Sousa, Nuno; Palha, Joana Almeida; Marques, Fernanda; Sousa, João Carlos. "Adult Hippocampal Neurogenesis Modulation by the Membrane-Associated Progesterone Receptor Family Member Neudesin". Frontiers in Cellular Neuroscience 12 (2018): http://dx.doi.org/10.3389/fncel.2018.00463.
    10.3389/fncel.2018.00463
  9. Falcão, Ana Mendanha; van Bruggen, David; Marques, Sueli; Meijer, Mandy; Jäkel, Sarah; Agirre, Eneritz; Samudyata; et al. "Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis". Nature Medicine 24 12 (2018): 1837-1844. http://dx.doi.org/10.1038/s41591-018-0236-y.
    10.1038/s41591-018-0236-y
  10. Marques, Sueli; van Bruggen, David; Vanichkina, Darya Pavlovna; Floriddia, Elisa Mariagrazia; Munguba, Hermany; Väremo, Leif; Giacomello, Stefania; et al. "Transcriptional Convergence of Oligodendrocyte Lineage Progenitors during Development". Developmental Cell 46 4 (2018): 504-517.e7. http://dx.doi.org/10.1016/j.devcel.2018.07.005.
    10.1016/j.devcel.2018.07.005
  11. Marques, S.; Zeisel, A.; Codeluppi, S.; van Bruggen, D.; Mendanha Falcao, A.; Xiao, L.; Li, H.; et al. "Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system". Science 352 6291 (2016): 1326-1329. http://dx.doi.org/10.1126/science.aaf6463.
    10.1126/science.aaf6463
  12. Castelo-Branco, Gonçalo; Stridh, Pernilla; Guerreiro-Cacais, André Ortlieb; Adzemovic, Milena Z.; Falcão, Ana Mendanha; Marta, Monica; Berglund, Rasmus; et al. "Acute treatment with valproic acid and l-thyroxine ameliorates clinical signs of experimental autoimmune encephalomyelitis and prevents brain pathology in DA rats". Neurobiology of Disease 71 (2014): 220-233. http://dx.doi.org/10.1016/j.nbd.2014.08.019.
    10.1016/j.nbd.2014.08.019
  13. Castelo-Branco G; Lilja T; Wallenborg K; Falcão AM; Marques SC; Gracias A; Solum D; et al. "Neural stem cell differentiation is dictated by distinct actions of nuclear receptor corepressors and histone deacetylases.". Stem cell reports (2014): http://europepmc.org/abstract/med/25241747.
    10.1016/j.stemcr.2014.07.008
  14. Mesquita SD; Ferreira AC; Falcao AM; Sousa JC; Oliveira TG; Correia-Neves M; Sousa N; Marques F; Palha JA. "Lipocalin 2 modulates the cellular response to amyloid beta.". Cell death and differentiation (2014): http://europepmc.org/abstract/med/24853299.
    10.1038/cdd.2014.68
  15. Falcão AM; Palha JA; Ferreira AC; Marques F; Sousa N; Sousa JC; Falcão, Ana Mendanha; et al. "Unbiased stereological method to assess proliferation throughout the subependymal zone.". Methods in molecular biology (Clifton, N.J.) (2013): 141-152. http://europepmc.org/abstract/med/23959988.
    10.1007/978-1-62703-508-8_12
  16. Falcão AM; Palha JA; Ferreira AC; Marques F; Sousa N; Sousa JC. "Topographical analysis of the subependymal zone neurogenic niche.". PloS one (2012): http://europepmc.org/abstract/med/22745673.
    10.1371/journal.pone.0038647
  17. Falcão, Ana Mendanha. "The path from the choroid plexus to the subventricular zone: go with the flow!". Frontiers in Cellular Neuroscience 6 (2012): http://dx.doi.org/10.3389/fncel.2012.00034.
    10.3389/fncel.2012.00034
  18. Pereira, V.H.; Salgado, A.J.; Oliveira, J.M.; Cerqueira, S.R.; Frias, A.M.; Fraga, J.S.; Roque, S.; et al. "In vivo biodistribution of carboxymethylchitosan/poly(amidoamine) dendrimer nanoparticles in rats". Journal of Bioactive and Compatible Polymers 26 6 (2011): 619-627. http://www.scopus.com/inward/record.url?eid=2-s2.0-81555220089&partnerID=MN8TOARS.
    10.1177/0883911511425567
  19. Marques, Fernanda; Sousa, João C; Coppola, Giovanni; Falcao, Ana M; Rodrigues, Ana João; Geschwind, Daniel H; Sousa, Nuno; Correia-Neves, Margarida; Palha, Joana A. "Kinetic Profile of the Transcriptome Changes Induced in the Choroid Plexus by Peripheral Inflammation". Journal of Cerebral Blood Flow & Metabolism 29 5 (2009): 921-932. http://dx.doi.org/10.1038/jcbfm.2009.15.
    10.1038/jcbfm.2009.15
  20. Marques F; Falcao AM; Sousa JC; Coppola G; Geschwind D; Sousa N; Correia-Neves M; Palha JA. "Altered iron metabolism is part of the choroid plexus response to peripheral inflammation.". Endocrinology (2009): http://europepmc.org/abstract/med/19213835.
    10.1210/en.2008-1610