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Pedro completed his PhD in Experimental Biology and Biomedicine in 2024 from the University of Coimbra, following a MSc in Medicinal Chemistry (2018) and a BSc in Chemistry (2015) from the University of Minho. Currently, he works as a Protein Engineer at SilicoLife. He has authored 14 research papers in peer-reviewed journals, contributed to 1 book chapter, and holds 1 registered patent. Additionally, he has organized 2 events and participated in 35. Pedro has been involved as a PhD fellow in 1 project, as research fellow in 2 projects, and as researcher in 3 other projects. He currently acts as a Review Editor for Frontiers in Catalysis and has reviewed 4 articles for other journals.
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Identification

Personal identification

Full name
PEDRO MIGUEL REIS FIGUEIREDO
Gender
Male

Citation names

  • Pedro R. Figueiredo

Author identifiers

Ciência ID
581F-4E7D-23AA
ORCID iD
0000-0002-1243-0265
Google Scholar ID
https://scholar.google.com/citations?user=Rs2AD0sAAAAJ&hl=en

Websites

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Beginner (A1) Elementary (A2) Beginner (A1) Elementary (A2)
Education
Degree Classification
2019 - 2024
Concluded
 Experimental Biology and Biomedicine (Doutoramento)
Major in Biotechnology and Health
Universidade de Coimbra, Portugal
"Enzymatic synthesis of biodegradable amphiphilic polymer-drugs for cancer treatment" (THESIS/DISSERTATION)
 Approved with praise and distinction
2015 - 2018
Concluded
 Medicinal Chemistry (Mestrado)
Universidade do Minho, Portugal
"Studies on the synthesis of adenine derivatives and analogues as anticancer drug candidates" (THESIS/DISSERTATION)
 17/20
2011 - 2015
Concluded
 Chemistry (Licenciatura)
Universidade do Minho, Portugal
"Síntese de derivados de antraquinona (para posterior aplicação como sensores eletroquímicos)" (THESIS/DISSERTATION)
 13/20
Affiliation

Science

Category
Host institution 		Employer
2022/10 - 2023/05 Research Trainee (Research) Universidade de Aveiro, Portugal
Universidade de Aveiro CICECO, Portugal
2018/10 - 2019/11 Researcher (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Others

Category
Host institution 		Employer
2024/02 - Current Protein Engineer SilicoLife SA, Portugal
2019/12 - 2024/01 PhD Candidate Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Projects

Grant

Designation Funders
2019/12 - 2024/01 Enzymatic synthesis of biodegradable amphiphilic polymer-drugs for cancer treatment
SFRH/BD/144303/2019
PhD Student Fellow
Universidade de Coimbra, Portugal

Universidade de Aveiro, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018/10 - 2019/11 Rational design of a thermostable esterase for the production of high-value bioplastics for biomedical applications
MIT-EXPL/ISF/0021/2017
Research Fellow
CNC.IBILI, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2023/06 - 2033/12 Enhancement of Proteins to address Health Conditions
2022.15818.CPCA.A2
Researcher
Fundacao para a Computacao Cientifica Nacional
Concluded
2020/01 - 2024/01 CIBB strategic plan
UIDP/04539/2020
Researcher
CNC.IBILI, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2022/05 - 2022/10 Protein Design in Biotechnology and Health
CPCA/A1/447491/2021
Researcher
Fundacao para a Computacao Cientifica Nacional
Concluded
2020/01 - 2020/06 Enzymatic Synthesis of Biopolymeric Conjugates for Advanced and Targeted Therapies
CPCA/A2/4568/2020
Researcher
Fundacao para a Computacao Cientifica Nacional
Concluded
Outputs

Publications

Book chapter
  1. Pedro R. Figueiredo; Beatriz C. Almeida; Alexandra T. P. Carvalho. "Enzymatic Polymerization of PCL-PEG Co-polymers for Biomedical Applications". In Multiscale Modeling from Macromolecules to Cell: Opportunities and Challenges of Biomolecular Simulations, edited by Tozzini, V., Palermo, G., Dal Peraro, M., Bonvin, A. M. J. J., Amaro, R. E.. Lausanne, Switzerland: Frontiers Media SA, 2020.
    10.3389/978-2-88966-109-1
Journal article
  1. Pedro R. Figueiredo; Armando J.D. Silvestre; Andreia F. Sousa; Alexandra T.P. Carvalho. "Reactivity of Pseudozyma antarctica lipase B towards the Synthesis of End-capped Polycaprolactone for Drug Delivery". Materials Today Chemistry (2025):
    doi.org/10.1016/j.mtchem.2025.102595
  2. André Carvalho; Teresa Pereira; Carlos Oliveira; Pedro R. Figueiredo; Alexandra T.P. Carvalho; David M. Pereira; Loic Hilliou; et al. "Tripeptides Featuring Dehydrophenylalanine and Homophenylalanine: Homo- Versus Hetero-Chirality and Sequence Effects on Self-Assembly and Gelation". Gels (2025):
    doi.org/10.3390/gels11030164
  3. Elina Marinho; Pedro R. Figueiredo; Rui Araújo; M. Fernanda Proença. "A Simple Protocol for the Synthesis of Perylene Bisimides from Perylene Tetracarboxylic Dianhydride". RSC Advances (2024):
    10.1039/d4ra01576b
  4. Pedro R. Figueiredo; Ricardo D. González; Alexandra T. P. Carvalho. "Insights into the Degradation of Polymer-Drug Conjugates by an Overexpressed Enzyme in Cancer Cells". Journal of Medicinal Chemistry (2023):
    10.1021/acs.jmedchem.2c01781
  5. Beatriz C. Almeida; Pedro R. Figueiredo; Daniel F.A.R. Dourado; Stephanie Paul; Derek Quinn; Thomas S. Moody; Andreia F. Sousa; Armando J.D. Silvestre; Alexandra T. P. Carvalho. "Development of Enzymatic Variants for the Synthesis of Bioresorbable Polyesters". Organic Process Research & Development (2022):
    10.1021/acs.oprd.1c00480
  6. Garcia, Juliana; Carvalho, Alexandra; Neves, Ricardo Pires; Malheiro, Rui; Rodrigues, Daniela F.; Pedro R. Figueiredo; Bovolini, Antonio; et al. "Antidotal effect of cyclosporine A against a-amanitin toxicity in CD-1 mice, at clinical relevant doses". Food and Chemical Toxicology (2022):
    10.1016/j.fct.2022.113198
  7. Carlos B. P. Oliveira; Sérgio R. S. Veloso; Pedro R. Figueiredo; Alexandra T. P. Carvalho; Loic Hilliou; Pereira, Renato B.; David M. Pereira; et al. "An injectable, naproxen-conjugated, supramolecular hydrogel with ultra-low critical gelation concentration - prepared from a known folate receptor ligand". Soft Matter (2022):
    10.1039/D2SM00121G
  8. Pedro R. Figueiredo; Ricardo D. González; Alexandra T. P. Carvalho. "Human Carboxylesterase 2 in Cocaine Metabolism". Molecular Catalysis (2021):
    10.1016/j.mcat.2021.111938
  9. Pedro R. Figueiredo; Sónia F.G. Santos; Beatriz C. Almeida; Isaura Simões; Alexandra T.P. Carvalho. "Introduction of a Glycine Linker Connecting the Heavy and Light Chains in Synthetic Cardosin B-Derived Rennet Changes the Specificity of Subpocket S3'". Journal of Physical Chemistry B (2021):
    10.1021/acs.jpcb.1c01826
  10. Beatriz C. Almeida; Jennifer Kaczmarek; Pedro R. Figueiredo; Kristala L. Jones Prather; Alexandra T.P. Carvalho. "Transcription factor allosteric regulation through substrate coordination to zinc". NAR Genomics and Bioinformatics (2021):
    10.1093/nargab/lqab033
  11. Pedro R. Figueiredo; Beatriz C. Almeida; Daniel F.A.R. Dourado; Andreia F. Sousa; Armando J.D. Silvestre; Alexandra T.P. Carvalho. "Enzymatic Synthesis of Polyesters: a QM/MM study". ChemCatChem (2020):
    10.1002/cctc.202000780
  12. Pedro Figueiredo; Beatriz C. Almeida; Alexandra T. P. Carvalho,. "Enzymatic Polymerization of PCL-PEG Co-polymers for Biomedical Applications". Frontiers in Molecular Biosciences (2019):
    10.3389/fmolb.2019.00109
  13. Beatriz C. Almeida; Pedro Figueiredo; Alexandra T.P. Carvalho. "PCL enzymatic hydrolysis: a mechanistic study". ACS Omega (2019):
    10.1021/acsomega.9b00345
  14. Pedro Figueiredo; Marta Costa; Olívia Pontes; Fátima Baltazar; Fernanda Proença. "Adenine Derivatives: Promising Candidates for Breast Cancer Treatment". European Journal of Organic Chemistry (2018):
    10.1002/ejoc.201800629
Thesis / Dissertation
  1. "Enzymatic synthesis of amphiphilic polymer-drug conjugates for cancer treatment". PhD, Universidade de Coimbra Instituto de Investigação Interdisciplinar, 2022. https://hdl.handle.net/10316/114335.
  2. "Studies on the synthesis of adenine derivatives and analogues as anticancer drug candidates". Master, Universidade do Minho, 2018. https://hdl.handle.net/1822/77491.

Intellectual property

Patent
  1. Alexandra T.P. Carvalho; Pedro R. Figueiredo; Beatriz C. Almeida; Daniel F.A.R. Dourado; Stephanie Paul; Derek J. Quinn; Thomas S. Moody; Andreia F. Sousa; Armando J.D. Silvestre. 2022. "Variants of hyperthermophilic carboxylesterase for polymer synthesis".
Activities

Ad Hoc journal article review

Journal title (ISSN) Publisher
2025/05 - Current Materials Today Chemistry (2468-5194) Elsevier
2025/04 - Current Computational and Theoretical Chemistry (2210-2728) Elsevier
2025/02 - Current Journal of Molecular Graphics and Modelling (1873-4243) Elsevier
2024/11 - Current Materials Today (1873-4103) Elsevier
2024/09 - Current Archives of Biochemistry and Biophysics (1096-0384) Elsevier
2024/04 - Current Frontiers in Catalysis (2673-7841) Frontiers Media SA
2022/07 - Current Journal of Medicinal Chemistry (1520-4804) American Chemical Society

Mentoring / Tutoring

Topic Student name
2025 - 2025 IEFP Professional Internship Supervisor Mariana Barros
2019 - 2019 BSc Dissertation Supervisor Osvaldo Silva
2018 - 2018 MSc Dissertation Supervisor João Ventura