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I have long held an interest in understanding how cell identity is acquired, maintained and ultimately modified or reversed. During my PhD, I have made my first contributions to the cellular reprogramming field by establishing cell fusion and heterokaryons as a new approach to study reprogramming mechanisms towards pluripotency. Of note I implicated the essential role of Polycomb repression in reprogramming. Then, during my postdoc, I brought cellular reprogramming concepts to hematopoeisis for the first time. I identified a combination of transcription factors that induces hemogenesis and established that cellular reprogramming approaches can inform the developmental specification of hematopoietic stem cells. My independent research group has now shown that cooperative transcription factor binding mediates hemogenic induction and pioneered cell fate reprogramming approaches in immunology with induced dendritic cells. This conceptual shift opens exciting opportunities to merge cellular reprogramming and cancer immunotherapy. I am an Assistant Investigator at Coimbra University and Associate Professor at Lund University and group leader of the Cell Reprogramming in Hematopoiesis and Immunity laboratory. I am also scientific co-founder of BRT Blood Reprogramming Technologies and Asgard Therapeutics.
Identification

Personal identification

Full name
Carlos Filipe Ribeiro Lemos Pereira

Citation names

  • Pereira, Carlos-Filipe

Author identifiers

Ciência ID
5611-D049-ABC6
ORCID iD
0000-0002-9724-1382

Email addresses

  • filipe.pereira@cnc.uc.pt (Professional)

Telephones

Mobile phone
  • 962664340 (Professional)

Addresses

  • Parque Tecnológico de Cantanhede, Núcleo 4, Lote 8, 3060-197, Cantanhede, Cantanhede, Portugal (Professional)

Websites

  • https://scholar.google.com/citations?user=TtsmHl4AAAAJ&hl=en (Scholar)
  • http://www.cnbc.pt/research/department_group_show.asp?iddep=1287&idgrp=1353 (Professional)
  • www.pereiralab.com (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Immunology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2004/09/01 - 2009/02/01
Concluded
PhD in Biomedical Sciences, Imperial College School of Medicine, London, UK (Doutoramento)
Major in Title: Epigenetic events underlying somatic cell reprogramming.
Imperial College Faculty of Medicine - Hammersmith Campus, United Kingdom
"Epigenetic events underlying somatic cell reprogramming" (THESIS/DISSERTATION)
Ph.D. thesis accepted without modifications.
1998/09/01 - 2002/07/31
Concluded
Biologia (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"n/a" (THESIS/DISSERTATION)
16
1998/07/31
Concluded
High school education (Ensino secundário)
Agrupamento de escolas de Muralhas do Minho, Valença, Portugal
18
Affiliation

Science

Category
Host institution
Employer
2017/09/01 - Current Principal Investigator (Research) Lunds universitet Institutionen för laboratoriemedicin Lund, Sweden
Lunds Universitet Arbets- och miljömedicin, Sweden
2015/02/18 - Current Auxiliary Researcher (Research) Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Projects

Grant

Designation Funders
2021 - 2026/12/31 Inducing antigen presentation in tumor cells with direct cell reprogramming
2020-00615
Principal investigator
Vetenskapsradet
2020 - 2025/05/31 Harnessing dendritic cell reprogramming for cancer immunotherapy
866448
Principal investigator
Lunds Universitet, Sweden
European Research Council
2021 - 2023/12/31 DiverDC: Understanding dendritic cell diversity with cell reprogramming
PTDC/MED-IMU/4520/2020
Principal investigator
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Fundação para a Ciência e a Tecnologia
2018 - 2021/12/31 ReproDC: Generating Antigen Presenting Cells by Direct Reprogramming
CENTRO-01-0145-FEDER-030013
Principal investigator
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Fundação para a Ciência e a Tecnologia
2019 - 2021/08/31 Elucidating the Mechanisms of Hematopoietic Reprogramming.
194-694
Principal investigator
Lunds Universitet, Sweden
Stiftelsen Olle Engkvist Byggmästare
2020 - 2021/05/31 Inducing NK cells with direct cell reprogramming
0062919
Principal investigator
Lund Universitet Institutionen för laboratoriemedicin Malmö, Sweden
2018 - 2021/03/31 ReProgram: Reconstructing the Program of Cancer Stem Cells
POCI-01-0145-FEDER-029017
Principal investigator
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Fundação para a Ciência e a Tecnologia
2020 - 2021/02/28 Dendritic Cell Therapy
0053036
Principal investigator
Lund Universitet Institutionen för laboratoriemedicin Malmö, Sweden
Novo Nordisk Fonden
2017 - 2021/02/28 Consortium CANCEL_STEM: Tackling CANcer STEM CELls: a challenge and an opportunity to advance in anti-cancer therapy
CANCEL_STEM
Principal investigator
Fundação para a Ciência e a Tecnologia
2019 - 2020/12/31 Generating Dendritic Cells by Direct Cell Reprogramming
2018-02442
Principal investigator
Lunds Universitet, Sweden
Vetenskapsradet
2018 - 2020/12 Generating Dendritic Cells by Direct Reprogramming
CAN 2017/745
Principal investigator
Lunds Universitet, Sweden
Cancerfonden
2019 - 2020/08/31 Mass spectrometry-based immunopeptidomic profiling in stem cells, disease and reprogramming.
StemTherapy Methods Grant.
Lund Universitet Institutionen för laboratoriemedicin Malmö, Sweden
2018 - 2020/02/29 AAC Grant for protecting intellectual property
04/SAICT/2017
Principal investigator
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Fundação para a Ciência e a Tecnologia
2015 - 2018/12/01 Hemoinduction: mechanisms underlying hemogenic induction in human fibrobalsts
PTDC/BIM-MED/0075/2014
Principal investigator
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Fundação para a Ciência e a Tecnologia
2018 - 2018/12 Generating Dendritic Cells by Direct Reprogramming
20180864
Principal investigator
Lunds Universitet, Sweden
Crafoordska Stiftelsen

Contract

Designation Funders
2017 - 2024/12/31 Wallenberg Center for Molecular Medicine 4-year career package
WCMMLUPEREIRA
Principal investigator
Wallenberg Centre for Molecular Medicine
2019 - 2022/09/30 Generating T Cells from Fibroblasts and Mesenchymal Stem Cells
AUTO-PEREIRA
Principal investigator
Lunds Universitet, Sweden
Autolus Ltd
Outputs

Publications

Book chapter
  1. Pereira, Carlos-Filipe; Lemischka, Ihor R.; Moore, Kateri. "Reprogramming cell fates: insights from combinatorial approaches". edited by Kanz, L.; Fibbe, W. E.; Lengerke, C.; Dick, J. E., 7-17. 2012.
    10.1111/j.1749-6632.2012.06508.x
Book review
  1. Kateri Moore; Pereira C.F.. "F1000Prime Recommendation". (2014): http://f1000.com/prime/718204823#eval793489162.
    10.3410/f.718204823.793489162
Journal article
  1. Pereira, Carlos-Filipe. "Single cell RNA-seq informs efficient reprogramming of human somatic cells to cross-presenting dendritic cells". Science Immunology (2022):
    Published
  2. Leigh, Nicholas D.; Pereira, Carlos-Filipe. "Reprogramming Stars #5: Regeneration, a Natural Reprogramming Process—An Interview with Dr. Nicholas Leigh". Cellular Reprogramming 24 1 (2022): 2-8. http://dx.doi.org/10.1089/cell.2022.29055.nl.
    10.1089/cell.2022.29055.nl
  3. Pádua, Diana; Pinto, Débora Filipa; Figueira, Paula; Pereira, Carlos Filipe; Almeida, Raquel; Mesquita, Patrícia. "HMGA1 Has Predictive Value in Response to Chemotherapy in Gastric Cancer". Current Oncology 29 1 (2021): 56-67. http://dx.doi.org/10.3390/curroncol29010005.
    10.3390/curroncol29010005
  4. Parmar, Malin; Pereira, Carlos-Filipe. "Reprogramming Stars #4: A Reprogramming Approach for Parkinson's Disease—An Interview with Dr. Malin Parmar". Cellular Reprogramming 23 6 (2021): 319-325. http://dx.doi.org/10.1089/cell.2021.29049.mp.
    10.1089/cell.2021.29049.mp
  5. Kaji, Keisuke; Pereira, Carlos-Filipe. "Reprogramming Stars #3: Mechanisms of iPSC Reprogramming—An Interview with Dr. Keisuke Kaji". Cellular Reprogramming 23 5 (2021): 264-269. http://dx.doi.org/10.1089/cell.2021.29046.kk.
    10.1089/cell.2021.29046.kk
  6. Ahlenius, Henrik; Pereira, Carlos-Filipe. "Reprogramming Stars #2: Reprogramming Towards Neural Lineages—An Interview with Dr. Henrik Ahlenius". Cellular Reprogramming 23 4 (2021): 200-205. http://dx.doi.org/10.1089/cell.2021.29044.ha.
    10.1089/cell.2021.29044.ha
  7. Zimmermannova, Olga; Caiado, Inês; Ferreira, Alexandra G.; Pereira, Carlos-Filipe. "Cell Fate Reprogramming in the Era of Cancer Immunotherapy". Frontiers in Immunology 12 (2021): http://dx.doi.org/10.3389/fimmu.2021.714822.
    10.3389/fimmu.2021.714822
  8. Pereira, Carlos-Filipe. "Reprogramming, The Journal". Cellular Reprogramming (2021): http://dx.doi.org/10.1089/cell.2021.0036.
    10.1089/cell.2021.0036
  9. Tsubouchi, Tomomi; Pereira, Carlos-Filipe. "Reprogramming Stars #1: Genome Programming Through the Cell Cycle—An Interview with Dr. Tomomi Tsubouchi". Cellular Reprogramming 23 3 (2021): 153-157. http://dx.doi.org/10.1089/cell.2021.29039.tt.
    10.1089/cell.2021.29039.tt
  10. Pereira, Carlos-Filipe. "Ontogenic Shifts in Cellular Fate are Linked to Proteotype Changes in Lineage-Biased Hematopoietic Progenitor Cells". Cell Reports (2021):
    In press
  11. Ulmert, Isabel; Henriques-Oliveira, Luís; Pereira, Carlos-Filipe; Lahl, Katharina. "Mononuclear phagocyte regulation by the transcription factor Blimp-1 in health and disease". Immunology 161 4 (2020): 303-313. http://dx.doi.org/10.1111/imm.13249.
    10.1111/imm.13249
  12. Pádua, Diana; Barros, Rita; Amaral, Ana Luísa; Mesquita, Patrícia; Freire, Ana Filipa; Sousa, Mafalda; Maia, André Filipe; et al. "A SOX2 Reporter System Identifies Gastric Cancer Stem-Like Cells Sensitive to Monensin". Cancers 12 2 (2020): 495. http://dx.doi.org/10.3390/cancers12020495.
    10.3390/cancers12020495
  13. Rosa, Fábio; Pires, Cristiana; Zimmermannova, Olga; Pereira, Carlos-Filipe. "Direct Reprogramming of Mouse Embryonic Fibroblasts to Conventional Type 1 Dendritic Cells by Enforced Expression of Transcription Factors". BIO-PROTOCOL 10 10 (2020): http://dx.doi.org/10.21769/bioprotoc.3619.
    10.21769/bioprotoc.3619
  14. Daniel, M.G.; Sachs, D.; Bernitz, J.M.; Fstkchyan, Y.; Rapp, K.; Satija, N.; Law, K.; et al. "Induction of human hemogenesis in adult fibroblasts by defined factors and hematopoietic coculture". FEBS Letters 593 23 (2019): 3266-3287. http://www.scopus.com/inward/record.url?eid=2-s2.0-85074051202&partnerID=MN8TOARS.
    10.1002/1873-3468.13621
  15. Silvério-Alves, R.; Gomes, A.M.; Kurochkin, I.; Moore, K.A.; Pereira, C.-F.. "Hemogenic Reprogramming of Human Fibroblasts by Enforced Expression of Transcription Factors". Journal of visualized experiments : JoVE 153 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85075191300&partnerID=MN8TOARS.
    10.3791/60112
  16. Pires, C.F.; Rosa, F.F.; Kurochkin, I.; Pereira, C.-F.. "Understanding and Modulating Immunity With Cell Reprogramming". Frontiers in Immunology 10 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85077260284&partnerID=MN8TOARS.
    10.3389/fimmu.2019.02809
  17. Andersson, R.; Pereira, C.-F.; Bauden, M.; Ansari, D.. "Is immunotherapy the holy grail for pancreatic cancer?". Immunotherapy 11 17 (2019): 1435-1438. http://www.scopus.com/inward/record.url?eid=2-s2.0-85076450369&partnerID=MN8TOARS.
    10.2217/imt-2019-0164
  18. Gomes, Andreia M.; Kurochkin, Ilia; Chang, Betty; Daniel, Michael; Law, Kenneth; Satija, Namita; Lachmann, Alexander; et al. "Cooperative Transcription Factor Induction Mediates Hemogenic Reprogramming". Cell Reports 25 10 (2018): 2821-+. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000452894600018&KeyUID=WOS:000452894600018.
    10.1016/j.celrep.2018.11.032
  19. Rosa, Fabio F.; Pires, Cristiana F.; Kurochkin, Ilia; Ferreira, Alexandra G.; Gomes, Andreia M.; Palma, Luis G.; Shaiv, Kritika; et al. "Direct reprogramming of fibroblasts into antigen-presenting dendritic cells". Science Immunology 3 30 (2018): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000452571800002&KeyUID=WOS:000452571800002.
    10.1126/sciimmunol.aau4292
  20. Ivanova, Natalia; Pereira, Carlos-Filipe; Lee, Dung-Fang. "Ihor R. Lemischka (1953-2017)". Cell Stem Cell 22 1 (2018): 16-+. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000419306500008&KeyUID=WOS:000419306500008.
    10.1016/j.stem.2017.12.015
  21. Ivanova, Natalia; Pereira, Carlos-Filipe; Lee, Dung-Fang. "Ihor R. Lemischka (1953-2017) Obituary". Cell 172 1-2 (2018): 1-+. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000419840100001&KeyUID=WOS:000419840100001.
    10.1016/j.cell.2017.12.028
  22. Gomes, A.; Pereira, C. -F.; Chang, B.; Kurochkin, I.; Daniel, M.; Law, K.; Satija, N.; et al. "INDUCTION OF HEMOGENIC REPROGRAMMING IN HUMAN FIBROBLASTS". Haematologica 102 (2017): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000404127006340&KeyUID=WOS:000404127006340.
  23. Vazão, H.; Rosa, S.; Barata, T.; Costa, R.; Pitrez, P.R.; Honório, I.; De Vries, M.R.; et al. "High-throughput identification of small molecules that affect human embryonic vascular development". Proceedings of the National Academy of Sciences of the United States of America 114 15 (2017): E3022-E3031. http://www.scopus.com/inward/record.url?eid=2-s2.0-85035214278&partnerID=MN8TOARS.
    10.1073/pnas.1617451114
  24. Freire, A.G.; Waghray, A.; Soares-da-Silva, F.; Resende, T.P.; Lee, D.-F.; Pereira, C.-F.; Nascimento, D.S.; Lemischka, I.R.; Pinto-do-Ó, P.. "Transient HES5 Activity Instructs Mesodermal Cells toward a Cardiac Fate". Stem Cell Reports 9 1 (2017): 136-148. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021126795&partnerID=MN8TOARS.
    10.1016/j.stemcr.2017.05.025
  25. Agnete Kirkeby; Thomas Perlmann; Carlos-Filipe Pereira. "The stem cell niche finds its true north". Development 143 16 (2016): 2877-2881. https://doi.org/10.1242/dev.140095.
    10.1242/dev.140095
  26. Pereira, C.-F.; Chang, B.; Gomes, A.; Bernitz, J.; Papatsenko, D.; Niu, X.; Swiers, G.; et al. "Hematopoietic Reprogramming In Vitro Informs In Vivo Identification of Hemogenic Precursors to Definitive Hematopoietic Stem Cells". Developmental Cell 36 5 (2016): 525-539. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959312876&partnerID=MN8TOARS.
    10.1016/j.devcel.2016.02.011
  27. Gomes, Andreia; Pereira, Carlos-Filipe; Papatsenko, Dmitri; Moore, Kateri Ann; Lemischka, Ihor. "MECHANISMS UNDERLYING HUMAN HEMOGENIC REPROGRAMMING". Experimental Hematology 44 9 (2016): S75-S76. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000382184600129&KeyUID=WOS:000382184600129.
    10.1016/j.exphem.2016.06.144
  28. Daniel, Michael; Fstkchyan, Yesai; Gomes, Andreia; Pereira, Carlos-Filipe; Lemischka, Ihor; Moore, Kateri Ann. "ZERO FOOTPRINT INDUCTION OF HUMAN HEMOGENESIS TO STUDY PATHOLOGIC DEVELOPMENTAL HEMATOPOIESIS IN FANCONI ANEMIA". Experimental Hematology 44 9 (2016): S65-S65. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000382184600098&KeyUID=WOS:000382184600098.
    10.1016/j.exphem.2016.06.112
  29. Daniel, M.G.; Pereira, C.-F.; Bernitz, J.M.; Lemischka, I.R.; Moore, K.. "Reprogramming mouse embryonic fibroblasts with transcription factors to induce a hemogenic program". Journal of Visualized Experiments 2016 118 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-85015946426&partnerID=MN8TOARS.
    10.3791/54372
  30. Daniel MG; Pereira CF; Lemischka IR; Moore KA. "Making a Hematopoietic Stem Cell.". (2015): http://europepmc.org/abstract/med/26526106.
    10.1016/j.tcb.2015.10.002
  31. Waghray, A.; Saiz, N.; Jayaprakash, A.D.; Freire, A.G.; Papatsenko, D.; Pereira, C.-F.; Lee, D.-F.; et al. "Tbx3 Controls Dppa3 Levels and Exit from Pluripotency toward Mesoderm". Stem Cell Reports 5 1 (2015): 97-110. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937523983&partnerID=MN8TOARS.
    10.1016/j.stemcr.2015.05.009
  32. Pereira, C.-F.; Lemischka, I.R.; Moore, K.. "'From blood to blood': De-differentiation of hematopoietic progenitors to stem cells". EMBO Journal 33 14 (2014): 1511-1513. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904561142&partnerID=MN8TOARS.
    10.15252/embj.201488980
  33. Pereira, C.-F.; Lemischka, I.R.; Moore, K.. ""There will be blood" from fibroblasts". Cell Cycle 13 3 (2014): 335-336. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896884486&partnerID=MN8TOARS.
    10.4161/cc.27507
  34. Pereira, Carlos-Filipe; Chang, Betty; Niu, Xiaohong; Gomes, Andreia; Swiers, Gemma; Azzoni, Emanuele; Schaniel, Christoph; et al. "DIRECT CONVERSION FROM MOUSE FIBROBLASTS INFORMS THE IDENTIFICATION OF HEMOGENIC PRECURSOR CELLS IN VIVO". Experimental Hematology 42 8 (2014): S55-S55. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000340344300196&KeyUID=WOS:000340344300196.
  35. Pereira, Carlos-Filipe; Chang, Betty; Qiu, Jiajing; Niu, Xiaohong; Papatsenko, Dmitri; Hendry, Caroline E; Clark, Neil R; et al. "Induction of a hemogenic program in mouse fibroblasts.". Cell stem cell 13 2 (2013): 205-18.
    10.1016/j.stem.2013.05.024
  36. Lee, Dung-Fang; Su, Jie; Ang, Yen-Sin; Carvajal-Vergara, Xonia; Mulero-Navarro, Sonia; Pereira, Carlos F.; Gingold, Julian; et al. "Regulation of Embryonic and Induced Pluripotency by Aurora Kinase-p53 Signaling". Cell Stem Cell 11 2 (2012): 179-194.
    10.1016/j.stem.2012.05.020
  37. Fidalgo, Miguel; Faiola, Francesco; Pereira, Carlos-Filipe; Ding, Junjun; Saunders, Arven; Gingold, Julian; Schaniel, Christoph; et al. "Zfp281 mediates Nanog autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming". Proceedings of the National Academy of Sciences of the United States of America 109 40 (2012): 16202-16207.
    10.1073/pnas.1208533109
  38. Piccolo, Francesco M.; Pereira, Carlos F.; Cantone, Irene; Brown, Karen; Tsubouchi, Tomomi; Soza-Ried, Jorge; Merkenschlager, Matthias; Fisher, Amanda G.. "Using heterokaryons to understand pluripotency and reprogramming". Philosophical Transactions of the Royal Society B-Biological Sciences 366 1575 (2011): 2260-2265.
    10.1098/rstb.2011.0004
  39. Santos, Joana; Pereira, C. Filipe; Di-Gregorio, Aida; Spruce, Thomas; Alder, Olivia; Rodriguez, Tristan; Azuara, Veronique; Merkenschlager, Matthias; Fisher, Amanda G.. "Differences in the epigenetic and reprogramming properties of pluripotent and extra-embryonic stem cells implicate chromatin remodelling as an important early event in the developing mouse embryo". Epigenetics & Chromatin 3 (2010):
    10.1186/1756-8935-3-1
  40. Kanhere, Aditi; Viiri, Keijo; Araujo, Carla C.; Rasaiyaah, Jane; Bouwman, Russell D.; Whyte, Warren A.; Pereira, C. Filipe; et al. "Short RNAs Are Transcribed from Repressed Polycomb Target Genes and Interact with Polycomb Repressive Complex-2". Molecular Cell 38 5 (2010): 675-688.
    10.1016/j.molcel.2010.03.019
  41. Pereira, Carlos F.; Piccolo, Francesco M.; Tsubouchi, Tomomi; Sauer, Stephan; Ryan, Natalie K.; Bruno, Ludovica; Landeira, David; et al. "ESCs Require PRC2 to Direct the Successful Reprogramming of Differentiated Cells toward Pluripotency". Cell Stem Cell 6 6 (2010): 547-556.
    10.1016/j.stem.2010.04.013
  42. Landeira, David; Sauer, Stephan; Poot, Raymond; Dvorkina, Maria; Mazzarella, Luca; Jorgensen, Helle F.; Pereira, C. Filipe; et al. "Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators". Nature Cell Biology 12 6 (2010): 618-U214.
    10.1038/ncb2065
  43. Schnetz, M.P.; Handoko, L.; Akhtar-Zaidi, B.; Bartels, C.F.; Pereira, C.F.; Fisher, A.G.; Adams, D.J.; et al. "CHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression.". PLoS genetics 6 7 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-79952538205&partnerID=MN8TOARS.
  44. Correia, Margareta P.; Cardoso, Elsa M.; Pereira, Carlos F.; Neves, Rui; Uhrberg, Markus; Arosa, Fernando A.. "Hepatocytes and IL-15: A Favorable Microenvironment for T Cell Survival and CD8(+) T Cell Differentiation". Journal of Immunology 182 10 (2009): 6149-6159.
    10.4049/jimmunol.0802470
  45. Banito, Ana; Rashid, Sheikh T.; Acosta, Juan Carlos; Li, SiDe; Pereira, Carlos F.; Geti, Imbisaat; Pinho, Sandra; et al. "Senescence impairs successful reprogramming to pluripotent stem cells". Genes & Development 23 18 (2009): 2134-2139.
    10.1101/gad.1811609
  46. Jorgensen, Helle F.; Terry, Anna; Beretta, Chiara; Pereira, C. Filipe; Leleu, Marion; Chen, Zhou-Feng; Kelly, Claire; Merkenschlager, Matthias; Fisher, Amanda G.. "REST selectively represses a subset of RE1-containing neuronal genes in mouse embryonic stem cells". Development 136 5 (2009): 715-721.
    10.1242/dev.028548
  47. Savarese, Fabio; Davila, Amparo; Nechanitzky, Robert; De La Rosa-Velazquez, Inti; Pereira, Carlos F.; Engelke, Rudolf; Takahashi, Keiko; et al. "Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression". Genes & Development 23 22 (2009): 2625-2638.
    10.1101/gad.1815709
  48. Pereira, C.F.; Fisher, A.G.. "Heterokaryon-based reprogramming for pluripotency". Current Protocols in Stem Cell Biology SUPPL. 9 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-65149087887&partnerID=MN8TOARS.
    10.1002/9780470151808.sc04b01s9
  49. Pereira, Carlos F.; Terranova, Remi; Ryan, Natalie K.; Santos, Joana; Morris, Kelly J.; Cui, Wei; Merkenschlager, Matthias; Fisher, Amanda G.. "Heterokaryon-Based Reprogramming of Human B Lymphocytes for Pluripotency Requires Oct4 but Not Sox2". Plos Genetics 4 9 (2008):
    10.1371/journal.pgen.1000170
  50. Nunes, R.J.; Castro, M.A.A.; Gonçalves, C.M.; Bamberger, M.; Pereira, C.F.; Bismuth, G.; Carmo, A.M.. "Protein interactions between CD2 and Lck are required for the lipid raft distribution of CD2". Journal of Immunology 180 2 (2008): 988-997. http://www.scopus.com/inward/record.url?eid=2-s2.0-40449133966&partnerID=MN8TOARS.
  51. Nunes, R.J.; Castro, M.A.A.; Gonçalves, C.M.; Bamberger, M.; Pereira, C.F.; Bismuth, G.; Carmo, A.M.. "Protein interactions between CD2 and Lck are required for the lipid raft distribution of CD2". Journal of Immunology 180 2 (2008): 988-997. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000252290000036&KeyUID=WOS:000252290000036.
    10.4049/jimmunol.180.2.988
  52. Terranova, R.; Pereira, C. F.; Du Roure, C.; Merkenschlager, M.; Fisher, A. G.. "Acquisition and extinction of gene expression programs are separable events in heterokaryon reprogramming". Journal of Cell Science 119 10 (2006): 2065-2072.
    10.1242/jcs.02945
  53. Cabrita, M.; Pereira, C. F.; Rodrigues, P.; Cardoso, E. M.; Arosa, F. A.. "Altered expression of CD1d molecules and lipid accumulation in the human hepatoma cell line HepG2 after iron loading". Febs Journal 272 1 (2005): 152-165.
    10.1111/j.1432-1033.2004.04387.x
  54. Arosa, F. A.; Pereira, C. F.; Fonseca, A. M.. "Red blood cells as modulators of T cell growth and survival". Current Pharmaceutical Design 10 2 (2004): 191-201.
    10.2174/1381612043453432
  55. Fonseca, A.M.; Pereira, C.F.; Porto, G.; Arosa, F.A.. "Red blood cells upregulate cytoprotective proteins and the labile iron pool in dividing human T cells despite a reduction in oxidative stress". Free Radical Biology and Medicine 35 11 (2003): 1404-1416. http://www.scopus.com/inward/record.url?eid=2-s2.0-0344875071&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2003.08.011
  56. Fonseca, A. M.; Pereira, C. F.; Porto, G.; Arosa, F. A.. "Red blood cells promote survival and cell cycle progression of human peripheral blood T cells independently of CD58/LFA-3 and heme compounds". Cellular Immunology 224 1 (2003): 17-28.
    10.1016/s0008-8749(03)00170-9
  57. Fonseca, A.M.; Pereira, C.F.; Porto, G.; Arosa, F.A.. "Red blood cells promote survival and cell cycle progression of human peripheral blood T cells independently of CD58/LFA-3 and heme compounds". Cellular Immunology 224 1 (2003): 17-28. http://www.scopus.com/inward/record.url?eid=2-s2.0-0142169441&partnerID=MN8TOARS.
    10.1016/S0008-8749(03)00170-9
Thesis / Dissertation
  1. Pereira, Carlos-Filipe. "Generating Dendritic Cells by Direct Cell Reprogramming". PhD, Lunds universitet Institutionen för laboratoriemedicin Lund, 2021.
  2. Pereira, Carlos-Filipe. "Elucidating mechanisms of antigen presentation in tumor cells". Master, Universität Wien, 2021.
  3. Pereira, Carlos-Filipe. "MIRNA-DIRECTED DENDRITIC CELL REPROGRAMMING". Master, Lund Universitet Institutionen för laboratoriemedicin Malmö, 2020.
  4. Pereira, Carlos-Filipe. "Inducing plasmacytoid dendritic like-cells with cell reprogramming". Master, Lund Universitet Institutionen för laboratoriemedicin Malmö, 2020.
  5. Pereira, Carlos-Filipe. "Reprogramming lung carcinoma cells into antigen presenting cells". Master, Lunds universitet Institutionen för laboratoriemedicin Lund, 2020.
  6. Pereira, Carlos-Filipe. "Understanding the genetic program of conventional dendritic cells type 2 with direct reprogramming". Master, Centro de Inovação em Biomedicina e Biotecnologia (CIBB), 2019.
  7. Pereira, Carlos-Filipe. "Elucidating Gata2 Transcription Factor Role during DNA Replication and Epigenetic Inheritance". Master, Centro de Inovação em Biomedicina e Biotecnologia (CIBB), 2019.
  8. Pereira, Carlos-Filipe. "Dissecting mechanisms underlying dendritic cell epigenetic reprogramming". Master, Lunds Universitet, 2019.
  9. Pereira, Carlos-Filipe. "Elucidating blood origin: from reprogramming to ontogeny". PhD, Universidade de Coimbra, 2018.
  10. Santos, Ana Raquel Pereira. "The role of LSD1/CoREST during hemogenic reprogramming.". Master, 2018. http://hdl.handle.net/10316/82432.
  11. Caiado, Inês Maria Nascimento. "Inducing Antigen Presentation in Tumor cells by Direct Reprogramming". Master, 2018. http://hdl.handle.net/10316/86201.
  12. Alves, Rita Alexandra Silvério. "Designing Transcription Factors for Efficient Hematopoietic Reprogramming". Master, 2017. http://hdl.handle.net/10316/83092.
  13. Pereira, Carlos-Filipe. "Generating a Personalized Immunotherapy by Reprogramming Fibroblasts to Regulatory T cells". Master, Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, 2017.
  14. Rosa, Fábio Alexandre Fiúza. "Direct Reprogramming of Fibroblasts to Dendritic Cells for Immunotherapy". Master, 2016. http://hdl.handle.net/10316/33773.
  15. Pereira, Carlos-Filipe. "Epigenetic events underlying somatic cell reprogramming.". PhD, Imperial College Faculty of Medicine - Hammersmith Campus, 2009.

Intellectual property

Patent
  1. Pereira, Carlos-Filipe. 2020. "Compositions for reprogramming cells into dendritic cells or antigen presenting cells, methods and uses thereof. In-license to start-up company Asgard Therapeutics AB.".
    Pending
  2. Pereira, Carlos-Filipe. 2015. "Methods for Programming Differentiated Cells Into Hematopoietic Stem Cells".
  3. Pereira, Carlos-Filipe. 2015. "Method for programming differentiated cells into hematopoietic stem cells. Option agreement granted to Summer Road, NYC, USA, 2017.". United States.
    Granted/Issued
Provisional application for patent
  1. 2020. "Compositions, constructs and vectors for cell reprogramming (NK cell reprogramming).".
    Protected
  2. 2019. "Compositions for reprogramming cells into plasmacytoid dendritic cells or interferon producing cells, methods and uses thereof.".
    Protected
  3. 2019. "Compositions for reprogramming into dendritic cells type 2 competent for antigen presentation, methods and uses thereof.".
    Protected

Other

Spin-off company
  1. 2018. Asgard Therapeutics. Cell Reprogramming and Cancer Immunotherapy. www.asgardthx.com.
  2. 2017. BRT Blood Reprogramming Technologies. Cell Reprogramming and Blood Regeneration. www.bloodrt.com.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/12/31 Since 2015 my research group has delivered 90 communications (42 oral communications and 48 posters).
2021/03/01 Cellular Reprogramming of Cancer Cells to Antigen-presenting Cells European Respiratory Society annual meeting
European Respiratory Society
2020/10/26 Harnessing Direct Cell Reprogramming for Cancer Immunotherapy Institute of Molecular Medicine, Faculty of Medicine of the University of Lisbon, Lisbon, Portugal.
Invited by Sergio Almeida. (lisbon, Portugal)
2020/09/20 Cell Reprogramming in Hematopoiesis and Immunity Institute seminar at St. Anna Children's hospital
Kaan Boztug (Vienna, Austria)
2020/06/23 In Vitro Generation of HSCs and Beyond 25th European Hematology Association (EHA) Congress, Virtual.
Invited by Kimmo Porkka.
2020/05/01 Generating human type 1 dendritic cells by direct cell reprogramming International Society for Stem Cell Research 2020
International Society for Stem Cell Research
2019/06/01 Reprogramming a Career in Science Future Faculty career paths and independence seminar.
Lund University, Lund, Sweden.
2019/05/01 Cell Reprogramming in Hematopoiesis and Immunity Principles of pluripotent stem cells underlying plant vitality symposium.
Tohoku University, Japan. Invited by Tomomi Tsubouchi. (Tohoku, Japan)
2019 Harnessing Dendritic Cell Reprogramming for Cancer Immunotherapy Biotech Research & Innovation Centre (BRIC) University of Copenhagen
BRIC external seminar series (Copenhagen, Denmark)
2019 Reprogramming cellular identity for regenerative medicine and cancer immunotherapy Umeå University
Cancer series seminar Umeå (Umeå, Sweden)
2019 Harnessing direct cell reprogramming for cancer immunotherapy Autolus UK
Autolus external seminar UK (London, United Kingdom)
2018 Elucidating Hematopoietic Reprogramming with Single Cell Resolution. Danish single cell symposium.
Novo Nordisk Foundation, Hellerup, Denmark. Invited by Konstantin Khodosevich. (Copenhagen, Denmark)
2018 New challenges of genetics - cellular reprogramming technologies TAIEX Regional Workshop on Biomedical Engineering – Genetics.
European Commission Expert Mission. (Sarajevo, Bosnia and Herzegovina)
2018 Cellular Reprogramming in Hematopoiesis and Immunity CIMUS external seminar series.
CIMUS, University of Santiago de Compostela, Santiago de Compostela, Spain. Invited by Miguel Fidalgo. (Santiago de Compostela, Spain)
2018 Developing a cancer immunotherapy based on direct dendritic cell reprogramming Lund Stem Cell Center, StemTherapy LU Innovation award pitch.
lund Stem Cell Center (Båstad, Sweden)
2018 Programming Definitive Hematopoiesis and Immunity Symposium in Memory and Celebration of Ihor R. Lemischka,
Mount Sinai School of Medicine. Invited by Marek Mlodzik & Saghi Ghaffari. (New York City, United States)
2018 Cellular Reprogramming in Hematopoiesis and Immunity Centre for genomics and oncological research, University of Granada, Granada, Spain.
Centre for genomics and oncological research external seminar series. Invited by David Landeira. (Granada, Spain)
2018 Cellular Reprogramming in Hematopoiesis and Immunity Department of Laboratory Medicine, Lund University, Lund, Sweden.
Department of Laboratory Medicine seminar series. (Lund, Sweden)
2018 Cellular Reprogramming in Hematopoiesis and Immunity Department of Pathology and Immunology, School of Medicine, University of Geneva, Geneva, Switzerland.
Department of Pathology and Immunology external seminar series. Invited by Julien Bertrand. (Geneva, Switzerland)
2018 Cellular Reprogramming in Hematopoiesis and Immunity International PhD Course in Molecular Medicine. Developmental Biology: Mechanisms, Models and Applications. Milan, Italy. 50 students.
San Raffaelle Institute (Milan, Italy)
2017 Cellular Reprogramming in Hematopoiesis and Immunity Department of Fundamental Oncology, University of Lausanne, Ludwig Center for Cancer Research, Lausanne, Switzerland.
Department of Fundamental Oncology external seminar series. Invited by Ping-Chih Ho. (Lausanne, Switzerland)
2017 Reprogramming a career in Science Lund Stem Cell Center Annual Retreat.
Lund Stem Cell Center (Ystad, Sweden)
2017 Programming Definitive Hematopoiesis and Immunity 46th Annual Scientific Meeting International Society for Experimental Hematology ISEH.
International Society for Experimental Hematology (Frankfurt, Germany)
2017 (Re) Programming Haematopoiesis and Immunity XV Congress SIC - Sociedade Iberica de Citometria. CCB.
Sociedade Iberica de Citometria. (Lisbon, Portugal)
2017 Programming Hematopoiesis and Immunity Division of Molecular Medicine and Gene Therapy, University of Lund, Sweden.
Division of Molecular Medicine and Gene Therapy external seminar (lund, Sweden)
2017 (Re) Programming Hematopoiesis and Immunity III Semana da Bioengenharia. Instituto Superior Técnico, Lisbon, Portugal.
Students from Instituto Superior Técnico. (Lisbon, Portugal)
2017 (Re) Programming Hematopoiesis and Immunity III – Encontro Nacional de Estudantes de Biotecnologia, Aveiro, Portugal.
Students of Biotechnology from Aveiro. (Aveiro, Portugal)
2016 Reprogramming a career in Science 5º Fórum Anual de Graduados Portugueses no Estrangeiro (GraPE), Coimbra, Portugal.
Associação de Graduados Portugueses no Estrangeiro (GraPE) (Coimbra, Portugal)
2016 Programming Hematopoiesis and Immunity 1st Meeting on Biomedical Research @ UC, Coimbra, Portugal.
Coimbra University (Coimbra, Portugal)
2016 Programming Definitive Hematopoiesis and Immunity MRC Centre for Regenerative Medicine, University of Edinburgh, UK.
MRC Centre for Regenerative Medicine. Invited by Keisuke Kaji. (Edinburgh, United Kingdom)
2016 Programming Definitive Hematopoiesis Centre of Regenerative Medicine (CRMB), Barcelona, Spain.
Centre of Regenerative Medicine (CRMB) external seminar series. Invited by Alessandra Giorgetti. (Barcelona, Spain)
2016 Programming Definitive Hematopoiesis Erasmus University Medical Center, Rotterdam, The Netherlands.
Erasmus University Medical Center external seminar. Invited by Frank Grosveld. (Rotterdam, Netherlands)
2016 Definir a origem das células estaminais do sangue com a reprogramação celular II Workshop of Stem Cells, Hospitals of the University of Coimbra, Portugal.
Hospitals of the University of Coimbra. Invited by Artur Paiva. (Coimbra, Portugal)
2016 Institute for Molecular Medicine, PhD Program Meeting, Lisbon, Portugal. Institute for Molecular Medicine, PhD Program Meeting.
PhD Program Meeting at IMM. (Lisbon, Portugal)
2016 Reprogramming at the single cell resolution Single Cell Analysis and High-throughput Biology, Cantanhede, Portugal.
UC-Biotech single cell analysis workshop (Cantanhede, Portugal)
2016 Programming definitive hematopoiesis ICVS epigenetics course, Institute for Health and Life Sciences, Braga, Portugal.
ICVS (Braga, Portugal)
2016 Defining hematopoietic stem cell origin with direct cell reprogramming ICVS flow cytometry course, Institute for Health and Life Sciences, Braga.
ICVS (Braga, Portugal)
2015 Programming definitive hematopoiesis Cancer Research UK Manchester Institute, Manchester, UK.
Cancer Research UK external seminar. Invited by Georges Lacaud. (Manchester, United Kingdom)
2015 Programming definitive hematopoiesis CNC.IBILI Seminar, Coimbra, Portugal.
CNC.IBILI (Coimbra, Portugal)
2015 Programming Definitive Hematopoiesis Plenary Lecture. Sociedade Portuguesa Células Estaminais Anual Meeting, Oeiras, Portugal.
Sociedade Portuguesa Células Estaminais (Oeiras, Portugal)
2015 Induction of hemogenesis in fibroblasts CNC.IBILI Seminar, Cantanhede, Portugal.
CNC.IBILI (Cantanhede, Portugal)
2015 Induction of Hemogeneis in fibroblasts Charles H. Revson Foundation, New York, USA.
Charles H. Revson Foundation (new york, United States)
2015 Programming definitive hematopoiesis Next Gen Stem Cell Meeting.
Next Gen Stem Cell Meeting. (Saratoga, United States)
2015 Programming and Reprogramming Cell Fate Royan Stem Cell Summer School, Cellular Reprogramming and Hematopoiesis, Royan Institute.
Royan Institute. (Tehran, Iran)
2014 Programming Definitive Hematopoiesis CNC.IBILI Annual Meeting.
CNC.IBILI (Coimbra, Portugal)
2014 Programming definitive hematopoiesis Weatherall Institute of Molecular Medicine, Oxford, UK. Invited by Marella de Brujin.
Weatherall Institute of Molecular Medicine. Invited by Marella de Brujin. (Oxford, United Kingdom)
2012 Induction of hemogenesis from fibroblasts Biocant Park, Cantanhede, Portugal.
Biocant Park external seminar series. (Cantanhede, Portugal)
2012 Programming hematopoietic stem cell generation with defined factors Gordon Conference: Reprogramming Cell Fate.
Gordon Conference: Reprogramming Cell Fate. (Galveston, United States)
2011 Heterokaryon-based reprogramming to pluripotency 7th Royan International Congress, Tehran, Iran.
Royan institute. (Tehran, Iran)
2009 ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotency. HBGS symposium in Epigenetics.
HBGS symposium in Epigenetics. (Helsinki, Finland)
2008 Heterokaryn-based reprogramming to pluripotency Cancer Research UK Stem Cell Meeting, London, UK.
Cancer Research UK (London, United Kingdom)
2006 Heterokaryn-based reprogramming to pluripotency Joint UK-CIRM Stem Cell Conference, Broadway, UK.
Joint UK-CIRM Stem Cell Conference. (Broadway, United Kingdom)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2021/01/01 - 2024/12/31 Elucidating dendritic cell diversity with cellular reprogramming
Supervisor of Luís Oliveira
Universidade de Coimbra, Portugal
2021/01/01 - 2024/12/31 Harnessing RNA programming for cancer immunotherapy
Supervisor of Nejc Arh
Lunds Universitet, Sweden
2020/01/01 - 2023/12/31 Inducing lymphoid cells with cellular reprogramming
Supervisor of Inês Caiado
Universidade de Coimbra, Portugal
2018/06/01 - 2022/05/31 Mitotic bookmarking in hematopoietic stem cells
Supervisor of Rita Alves
Universidade de Coimbra, Portugal

Lunds Universitet, Sweden
2018/01/01 - 2021/12/31 Inducing antigen presentation in tumor cells with direct cell reprogramming
Supervisor of Alexandra Gabriela Ferreira
Universidade de Coimbra, Portugal

Lunds Universitet, Sweden
2018/01/01 - 2021/06/10 Generating Dendritic Cells by Direct Cell Reprogramming
Supervisor of Fábio Rosa
Universidade de Coimbra, Portugal

Lunds Universitet, Sweden
2020/01/01 - 2021/02/25 Elucidating mechanisms of antigen presentation in tumor cells
Supervisor of Ervin Ascic
Universität Wien, Austria
2019/09/01 - 2020/07/31 Reprogramming lung carcinoma cells into antigen presenting cells
Supervisor of Ariane Eceiza Tenreiro
Lunds Universitet, Sweden
2019/09/01 - 2020/07/31 MIRNA-DIRECTED DENDRITIC CELL REPROGRAMMING
Supervisor of Nejc Arh
Lunds Universitet, Sweden
2019/09/01 - 2020/07/31 Inducing plasmacytoid dendritic like-cells with cell reprogramming
Supervisor of Jennyfer Pastor Gómez
Lunds Universitet, Sweden
2018/09/01 - 2019/07/31 Dissecting mechanisms underlying dendritic cell epigenetic reprogramming
Supervisor of Svandís Þóra Sæmundsdóttir
Lunds Universitet, Sweden
2019 - 2019 Understanding the Genetic Program of Conventional Dendritic Cells Type 2 with Direct Cell Reprogramming
Supervisor of Luís Filipe Henriques Oliveira
Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019 - 2019 Elucidating Gata2 transcription factor role during DNA replication and epigenetic inheritance
Supervisor of Catarina Milheiro Soares da Silva
Bioquímica (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018 - 2018 Inducing Antigen Presentation in Tumor cells by Direct Reprogramming
Supervisor of Inês Maria Nascimento Caiado
Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018 - 2018 The role of LSD1/CoREST during hemogenic reprogramming.
Supervisor of Ana Raquel Pereira Santos
Investigação Biomédica (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2017 - 2017 Designing Transcription Factors for Efficient Hematopoietic Reprogramming
Supervisor of Rita Alexandra Silvério Alves
Bioquímica (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017 - 2017 Generating a Personalized Immunotherapy by Reprogramming Fibroblasts to Regulatory T Cells
Supervisor of Alexandra Gabriela Barros Ferreira
Genética Molecular (Master)
Universidade do Minho, Portugal
2016 - 2016 Elucidating Blood Origin: From Reprogramming to Ontogeny
Supervisor of Andreia Marques Gomes
Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal

Event organisation

Event name
Type of event (Role)
Institution / Organization
2018 - 2020 2020 Lund stem cell centre first author symposium, Lund , Sweden. 2018 Lund stem cell centre retreat organising committee, Lund, Sweden. (2018 - 2020)
Symposium
Lunds Universitet, Sweden
2003 - 2019 2019 Immunology day, part of the international immunology day, Cantanhede, Portugal. 2017 Immunology day, part of the international immunology day, Cantanhede, Portugal. 2016 Immunology day, part of the international immunology day, Cantanhede, Portugal. 2015 Flow Cytometry Workshop (theoretical and practical), Cantanhede, Portugal. 2013 International Conference on Stem Cells for Drug Screening, Cantanhede, Portugal. 2003 GABBA PhD program Annual Symposium: Nanotechnology and Medicine, Porto, Portugal. (2003 - 2019)
Symposium (Co-organisor)
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2017 2018 Alban Johansson, Molecular Biology Lund University, Lund, Sweden 2017 Mariana Alves, University of Coimbra, Portugal.
(Thesis) Main arguer
Opponent for 2 master student thesis (Master)
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2015 2018 Sílvia Arroz Madeira, University of Lisbon, Lisbon, Portugal. 2017 Inês Sofia Alvarez Martins, Faculty of Medicine University of Lisbon, Portugal. 2017 Ana Francisca Silva de Lima, Faculty of Sciences and Technology, Nova University of Lisbon, Portugal. 2015 Magdalena Bronislawa Florkowska, University of Manchester, UK. PhD opponent for 4 students (PhD)
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal

Association member

Society Organization name Role
2010/01/01 - Current Membership of scientific societies: 2016 – Associated Member, Portuguese Society for Developmental Biology. 2015 – Associated Member, Portuguese Immunology Society. 2015 – Associated Member, Portuguese Society for Stem Cells and Cell Therapies. 2012 – 2015 Individual Member, New York Academy of Sciences. 2011 – Associated Member, International Society for Experimental Hematology. 2010 – Associated Member, International Society for Stem Cell Research.
2016 - 2020 Membership of scientific societies: 2020 – Active Member, ASH American Society of Hematology. 2020 – Active Member, EMDS European Macrophage & Dendritic Cell Society. 2020 – Active Member, SITC Society for Immunotherapy of Cancer. 2017 – Active Member, EHA European Hematology Association. 2017 – Active Member, AACR American Association for Cancer Research. 2015 – 2017 Governing Board, Portuguese Society for Stem Cells and Cell Therapies. 2016 – Academic Member, European Society of Gene and Cell Therapy.
2003 - 2020 Associate Faculty Member, Faculty of 1000. Associate Faculty Member, Faculty of 1000.

Committee member

Activity description
Role
Institution / Organization
2018 - 2020 2018-2021 WCMM Regenerative Medicine Research School steering board, Lund University, Sweden.
Other
Lunds Universitet, Sweden
2015 - 2020 PhD Thesis Committee Member: Sara Norbalt, Sandra Capellera Garcia and Trine Kristiansen, Lund University, Sweden; João Mendes, University of Coimbra, Portugal.
Member
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal

Consulting

Activity description Institution / Organization
2019 - Current Consultant for the company Autolus Ltd, UK. Lunds Universitet, Sweden

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2021/02/18 - Current 2021- Coordinator of the stem cells and regenerative medicine 5-week course at the Biomedicine Master's Program. Lund University. 25 students. Stem cells and Regenerative Medicine (Master) Lunds universitet Lunds stamcellscentrum, Sweden
2018 - 2020 2018-2020 Lecturer at WCMM Regenerative Medicine Research School, Lund, Sweden. 30 students. 2018 Lecturer at the International PhD Course in Molecular Medicine: Developmental Biology: Mechanisms, Models and Applications, San Raffaele Telethon Institute for Gene Therapy, Milan, Italy. 60 students. 2018 Lecturer at the symposium on single cell technologies in stem cell research, Lund University, Sweden. 30 students. (Doktor (PhD)) Lunds Universitet, Sweden
2015 - 2017 2015 - 2017 Lecturer at the MIT-Portugal doctoral program, Cellular Reprogramming, ITQB, Nova University of Lisbon, Portugal. 12 students. 2015 ¿ 2017 Lecturer at the PDBEB doctoral program, Cellular Reprogramming, University of Coimbra, Portugal. 12 students. 2016 Lecturer at the doctoral program in metabolism, Cellular Reprogramming and Hematopoiesis, Faculty of Medicine, University of Porto, Portugal. 6 students. 2016 Lecturer at the Cellular & Molecular Biology Master Program, Flow Cytometry, University of Coimbra, Portugal. 60 students. (Doutoramento) Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2020 Public engagement: Participation in the various media including interviews for national TV, radio and newspapers. Lecture to high school students and teachers, Instituto de Educação e Cidadania, Mamarrosa, Portugal. Contribution to ART LAB, Science Xplore. A six-day summer science and art workshop for high school students, Viseu, Portugal. European Researchers' Night: exploring science whilst having fun, Museum of Science, Coimbra, Portugal. Contribution to “Saberás tu” journal, Ciência Viva Program, Lisbon, Portugal.
2005 Public engagemnet: CORDIS documentary on epigenetics “The hidden life of our genes”, London, UK. Royal Albert Hall Exhibition, “Scopic”, inter-disciplinary educational initiative for school students, engaging them in both the sciences and the arts, London, UK. “Genes talking” live sequencing lab Institute of Contemporary Arts, London, UK.

Journal scientific committee

Journal title (ISSN) Publisher
2021/03/01 - Current Editor-in-Chief Cellular Reprogramming Mary Ann Liebert
2017 - Current Editorial Board Member, Cancer reports and reviews.
2013 - Current Editorial Board Member, International Journal of Stem Cell Research and Transplantation.

Mentoring / Tutoring

Topic Student name
2015 - 2030 Cell Reprogramming in Hematopoiesis and Immunity Laboratory: Current main supervisor of 5 postdocs, 6 PhD students, 4 MSC students, 1 intern and 1 technician Current supervisor of a team with 17 members
2015 - 2030 Research team and funding: Total funding raised by my research group since 2015 in grants, fellowships , innovation and awards: 11 million euros. Current supervisor of a team with 17 members

Other jury / evaluation

Activity description Institution / Organization
2015 - 2020 Reviewer for Nature, Science Immunology, Cell Stem Cell, Cell Reports, Development, Stem Cell Reports, Stem Cells and Development, Nature Communications and others. Total of 39 verified reviews at Publons (https://bit.ly/2UbAich). Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2016 - 2019 2019 Grant reviewer for the Medical Research Council, UK. 2018 Grant reviewer for the French National Research Agency, ANR, France. 2018 Reviewer for future faculty, postdoctoral application for the Swedish research council. 2016 Grant reviewer for FCT, cooperation grant between Portugal and India, FCT, Portugal. Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Distinctions

Award

2020 Mount Sinai School of Medicine KiiLN entrepreneurship award.
Icahn School of Medicine at Mount Sinai, United States
2019 Medal of merit for outstanding achievements in cell reprogramming
Municipio de Valença, Portugal
2018 StemTherapy LU Innovation award.
Lunds Universitet, Sweden

Other distinction

2021 Swedish Research Council (VR) Consolidator Grant
Vetenskapsradet, Sweden
2020 ERC Consolidator Grant
European Commission, Belgium
2017 FCT Investigator Program Award. 5-year starting grant. Final classification of 8,6/9,0 (ranked #1 out of 102 applicants evaluated by the Biological and Animal Sciences international panel).
2017 Wallenberg Fellowship Molecular Medicine at Lund University, Lund, Sweden. 4- year tenure-track appointment with starting package.
Wallenberg Centre for Molecular Medicine , Sweden
2016 Innocentive Challenge 9933820 by seeker Boehringer Ingelheim. Second Place Award selected from 198 international solvers. Novel Treatment Approaches to Stop the Allergic March towards Asthma.
2015 Marie Curie International Incoming Fellowship, 2015-2017.
2014 Icahn School of Medicine at Mount Sinai post-doctoral travel award 2014
2014 ISEH travel grant award 2014, Montreal, Canada.
2013 Charles H. Revson senior fellowship in Biomedical Science.
2012 Icahn School of Medicine at Mount Sinai post-doctoral travel award 2012.
2010 EMBO Long-term postdoctoral fellowship.
2003 Doctoral fellowship from the Foundation for Science and Technology.
1998 University of Helsinki travel award.
1995 Rotary Club merit award, Portugal, 1995.