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Helena Aires is an investigator in CNC.IBILI, University of Coimbra, a recognized Aging research center. She did both her Bachelor's Degree in Biology and Master's Degree in Cellular and Molecular Biology at the University of Coimbra. Her Master's dissertation project "High Throughput Identification of Polymeric Compounds that affect Human Vascular Cell Senescence" was developed under the supervision of Dr. Patrícia Pitrez, in the laboratory of Dr. Lino Ferreira (ERA-Chair holder of Coimbra University). The project involved a high throughput screening in senescent vascular cells to identify senolytic drugs amongst a library of 115 polymer-based compounds. Senolytic drugs specifically target apoptosis in senescent cells and are under the scope of researchers on the search for anti-aging therapeutic strategies. Helena Aires' master thesis revealed two new senolytic compounds with the potential to be used in a vascular application. At the moment, Helena is working in the Biomaterials and Stem-Cell based Therapeutics Laboratory, at UC-Biotech, as a PhD student, where she is leading a project involving the development of delivery systems for senolytic compounds targeted to senescent vascular cells. This project is being developed in collaboration with Dr. João Passos from Mayo Clinic Rochester Minnesota, USA. In 2021, Helena was awarded a 1-year Fulbright scholarship to develop part of her PhD project at Mayo Clinic.
Identification

Personal identification

Full name
Helena Isabel Reis Aires

Citation names

  • H.R. Aires

Author identifiers

Ciência ID
5519-A406-0647
ORCID iD
0000-0002-5878-8131

Email addresses

  • uc2012171541@student.uc.pt (Professional)
  • reisaires.helena@mayo.edu (Professional)

Addresses

  • UC-Biotech, Núcleo 4, Lote 8, 3060-197, Cantanhede, Coimbra, Portugal (Professional)
  • Mayo Clinic Rochester 200 1st ST SW GUGGENHEIM 6-38D, 55904, ROCHESTER, MINNESOTA, United States (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Molecular Biology
  • Medical and Health Sciences - Medical Biotechnology - Biomaterials

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Spanish; Castilian Elementary (A2) Advanced (C1) Intermediate (B1) Advanced (C1) Elementary (A2)
Education
Degree Classification
2020 - 2024
Ongoing
Doutoramento em Ciências da Saúde (Doutoramento)
Major in Investigação Biomédica
Universidade de Coimbra Faculdade de Medicina, Portugal
2020 - 2024
Ongoing
EIT Health PhD Ageing School (Doutoramento)
Universidade de Coimbra, Portugal
2020 - 2024
Ongoing
PhD in Health Sciences (Doktor (PhD))
Major in Investigação Biomédica
Mayo Clinic Graduate School of Biomedical Sciences, United States
2020/11/09 - 2020/11/20
Concluded
IV Modular Training in Laboratory Animal Science (Diploma de especialização)
Major in Experimentação Animal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
15,9
2016/08/04 - 2018/09/25
Concluded
Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra, Portugal
"High Throughput Identification of Polymeric Compounds that affect Senescent Human Vascular Cells" (THESIS/DISSERTATION)
19.000
2013/09/09 - 2016/06/28
Concluded
Biologia (Licenciatura)
Universidade de Coimbra, Portugal
16.700
Affiliation

Science

Category
Host institution
Employer
2019 - Current Researcher (Research) Universidade de Coimbra Faculdade de Medicina, Portugal
2021/03/01 - 2022/07 Visiting Researcher (Research) Mayo Clinic Department of Physiology and Biomedical Engineering, United States
Mayo Clinic Department of Physiology and Biomedical Engineering, United States
2018/08/01 - 2019/12/31 Researcher (Research) Universidade de Coimbra, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal
Projects

Contract

Designation Funders
2023/03/01 - 2024/08/31 Sistema de entrega senolítica direcionada para tratar a cirrose hepática/ Targeted senolytic delivery system to treat liver cirrhosis
2022.02783.PTDC
PhD Student Fellow
Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/03/01 - 2024/08 Uma estratégica terapêutica para combater o envelhecimento da barreira hemato-encefálica (BBB) / A therapeutic strategy to fight blood-brain-barrier (BBB) ageing
PTDC/BTM-SAL/5174/2020
PhD Student Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2019/12/31 CNC. IBILI
UID/NEU/04539/2019
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Pitrez, Patrícia R.; Aires, Helena R.; Tomé, Inês; Ferreira, Rita Sá; Ferreira, Lino. "Physiological and Pathological Vascular Aging". In Biophysical Regulation of Vascular Differentiation and Assembly, edited by Sharon Gerecht, 51-72. Gewerbestrasse, Switzerland: Springer International Publishing, 2018.
    Published • 10.1007/978-3-319-99319-5_3
Conference abstract
  1. H.R. Aires; Pitrez, Patricia R.; Francisco, Vitor; Ferreira, Lino. "A Nanoparticle-based Innovative Senotherapy". Paper presented in European Tissue Repair Society (ETRS) and Portuguese Society of Stem Cells and Cell Therapies (SPCE-TC) Joint Meeting, Coimbra, 2023.
  2. Aires, Helena R.; Pitrez, Patricia R.; Ferreira, Lino. Corresponding author: Aires, Helena R.. "Senolytic: a therapeutic solution for vascular aging". 2019.
    Published
Conference poster
  1. H.R. Aires; Pitrez, Patricia R.; Ferreira, Lino. "Senolytics: a therapeutic solution for vascular aging?". 2022.
  2. H.R. Aires; Pitrez, Patricia R.; Ferreira, Lino. "Senolytics: a therapeutic solution for vascular aging?". 2022.
Thesis / Dissertation
  1. "High-throughput identification of polymeric compounds that affect human vascular cell senescence". Master, Universidade de Coimbra Centro de Neurociências e Biologia Celular, 2018. https://hdl.handle.net/10316/86143.
Activities

Event organisation

Event name
Type of event (Role)
Institution / Organization
2018 - 2019 Noite Europeia dos Investigadores (2018 - 2019)
Other (Co-organisor)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2023/12 - Current Training on Super-Resolution Microscopy, RESETageing project.
Workshop
Training on Super-Resolution Microscopy
Universidade de Coimbra, Portugal
2024/06/18 - 2024/06/19 ZEISS arivis Course for 3D &4D Image Analysis
Workshop
ZEISS arivis Course for 3D &4D Image Analysis
Carl Zeiss Ltd, United Kingdom
2024/05/27 - 2024/05/29 Training in Brightfield and Fluorescence Imaging analysis with machine learning and automated workflows.
Workshop
Introduction to QuPath software 3rd Edition
Portuguese Platform of BioImaging, Portugal
2023/01/23 - 2023/01/27 Business Ignition Program in Ageing
Workshop
Instituto Pedro Nunes, Portugal

Universidade de Coimbra, Portugal
2023/01/16 - 2023/01/20 Workshop In Innovation in Aging
Workshop
Instituto Pedro Nunes, Portugal

Universidade de Coimbra, Portugal
2020 - 2023 Noite Europeia dos Investigadores
Other
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2022/12/06 - 2022/12/07 Ageing With(Out) borders Congress
Conference
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2022/09/16 - 2022/09/17 2ª Conferência RESETageing
Conference
Into Newcastle University, United Kingdom

Mentoring / Tutoring

Topic Student name
2023/10/02 - 2024/05/17 Master Thesis " Nanoparticles to target senescent cells" Sofia Barbagallo
Distinctions

Award

2023 1st prize in Workshop Innovation and Business Ignition in Ageing
Instituto Pedro Nunes, Portugal

Universidade de Coimbra, Portugal
2020 Bolsas Fulbright para Investigação, com o apoio da FCT
Fulbright Portugal, Portugal
2019 PhD Scholarship SFRH/BD/146996/2019
Fundação para a Ciência e a Tecnologia, Portugal
2018 Merit Fellowship: Master's in Cellular and Molecular Biology
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal