Personal identification

Full name

Clara Monteiro

Citation names

• Monteiro, Clara

Author identifiers

Ciência ID

5517-BF99-80CC

ORCID iD

0000-0003-4279-4067

Researcher Id

J-8565-2013

Scopus Author Id

13402813100

Email addresses

• cmonteir@med.up.pt (Professional)
• cmonteir@ibmc.up.pt (Professional)

Addresses

• Faculdade de Medicina da Universidade do Porto, Departamento de Biomedicina, piso 4 - Rua Doutor Plácido da Costa , 4200-450, Porto, Porto, Portugal (Professional)

Knowledge fields

• Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English

	Degree	Classification
2013 Concluded	Neurociências (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal
2002 Concluded	Biologia do Desenvolvimento e Reprodução Vegetal (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal
1997 Concluded	Bioquímica (Licenciatura) Universidade do Porto Faculdade de Ciências, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2013 - Current	Assistant Professor (University Teacher)	Universidade do Porto Faculdade de Medicina, Portugal
2008 - 2013	Assistant (University Teacher)	Universidade do Porto Faculdade de Medicina, Portugal

Grant

	Designation	Funders
2007 - 2011	Papel do fator de transcrição Prrxl1 no processamento nociceptivo; alterações cognitivas no modelo knockout. SFRH/BD/28752/2006 PhD Student Fellow	Fundação para a Ciência e a Tecnologia Concluded

Contract

	Designation	Funders
2023/01/15 - 2026/01/14	Circuitos dopaminérgicos de codificação de hábitos e dependência em modelos animais de dor crónica 2022.05193.PTDC Researcher Universidade do Porto Faculdade de Medicina, Portugal Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2022/01/01 - 2023/06/30	Hidrogel biomimético para aumento de biocompatibilidade de eléctrodos neurais para implantação crónica. EXPL/BTM-MAT/1499/2021 Principal investigator Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/07/15 - 2021/07/14	Codificação de sinais de recompensa em populações neuronais do circuito dopaminérgico: estudo optogenético dos correlatos neuronais de decisão e expectativa PTDC/MED-NEU/28498/2017 Researcher Universidade do Porto, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018/07/15 - 2021/07/14	Modulação optogenética da sinalização GABAérgica e dopaminérgica do córtex pré-frontal para a reversão de défices cognitivos relacionados com dor crónica PTDC/MED-NEU/28181/2017 Researcher Universidade do Porto, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2016/05/01 - 2018/10/31	Porto Neurosciences and Neurologic Disease Research Initiative at i3S Norte-01-0145-FEDER-000008 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal	Concluded
2013/07/01 - 2015/09/30	Modulação de oscilações no circuito fronto-hipocampal: correlatos neurofisiológicos e comportamentais PTDC/NEU-SCC/1516/2012 Researcher Universidade do Porto Faculdade de Medicina, Portugal Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2010/04/01 - 2013/03/31	Papel dos determinantes embrionários nociceptivos na dor crónica em ratinhos adultos PTDC/SAU-NEU/101995/2008 Researcher Universidade do Porto Faculdade de Medicina, Portugal Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2013 - 2013	A Codificação neuronal de Valor no circuito corticoestriado de recompensa e aversão. PTDC/SAU-NEU/100773/2008 Research Fellow	Fundação para a Ciência e a Tecnologia Concluded
2011 - 2013	A Experiência da Dor: alterações funcionais induzidas por Dor Crónica nos circuitos neuronais de recompensa e aversão. 126/2008 - Fundação BIAL Research Fellow	Fundação Bial Concluded
2011/01/01 - 2012/12/31	Projecto Estratégico - LA 2 - 2011-2012 PEst-C/SAU/LA0002/2011 Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal Instituto Nacional de Engenharia Biomédica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2005 - 2007	Recuperação da percepção táctil por microestimulação de fibras nervosas periféricas. POCTI/59383/2004 Research Fellow	Fundação para a Ciência e a Tecnologia Concluded
2005 - 2005	A Consciência da Dor: alterações induzidas por Dor Crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa. projecto BIAL 84/2004 Research Fellow	Fundação Bial Concluded
2004 - 2005	Functional Dynamics of Pain. POCTI/38995/2001 Research Fellow	Fundação para a Ciência e a Tecnologia Concluded
2002 - 2004	ROSANA – Representation of Stimuli as Neural Activity. Projecto Europeu IST-2001-34892 Research Fellow	Concluded
2001 - 2002	Neurotrofinas, Síntese Peptídica e Abstinência Alcoólica: Estudo nos Núcleos Supraquiasmático e Basal do Rato. POCTI/1999/NSE/35767 Research Fellow	Fundação para a Ciência e a Tecnologia Concluded

Publications

Conference poster

Cerqueira-Nunes, Mariana; Mobina Alemi; Amaral-Pereira, Ana; Monteiro, Clara; Galhardo, Vasco; Cardoso-Cruz, Helder. Corresponding author: Cerqueira-Nunes, Mariana. "Optogenetic inhibition of habenula-ventral tegmental microcircuit reverses pain-related working memory deficits". Paper presented in Champalimaud Research Symposium 2023, 2023. Cerqueira-Nunes, Mariana; Galhardo, Vasco; Monteiro, Clara; Cardoso-Cruz, Helder. Corresponding author: Cerqueira-Nunes, Mariana. "Effects of nucleus accumbens shell lesion on neuropathic pain-related working memory deficits and pain perception". Paper presented in Second International Meeting of Portuguese Spinal Cord Injury Researchers. 13 June, Porto, Portugal., 2022. Nunes, Mariana; Galhardo, Vasco; Monteiro, Clara; Cardoso-Cruz, Helder. "Infralimbic-nucleus accumbens microcircuit underlies neuropathic pain-related working memory deficits". Paper presented in 15º Encontro de Investigação Jovem da Universidade do Porto (IJUP), May 4-6th, 2022. Rodrigues, Diogo R.; Cardoso-Cruz, Helder; Galhardo, Vasco; Monteiro, Clara. "Epigenetics in the Brain: A Study in a Rat Model of Neuropathic Pain". Paper presented in 14º Encontro Investigação Jovem da Universidade do Porto, Porto, Portugal, 2021. Faria, Joana; Galhardo, Vasco; Monteiro, Clara; Cardoso-Cruz, Helder. "The role of corticostriatal circuitry in pain responses and pain-related working memory deficits". Paper presented in 13º Encontro de Investigação Jovem da Universidade do Porto, 13-15 Fevereiro 2020, Reitoria, Porto, PORTUGAL, 2020. Pereira, Ana Raquel; Alemi, Mobina; Paiva, Pedro; Monteiro, Clara; Galhardo, Vasco; Cardoso-Cruz, Helder. "Optogenetic neuromodulation of prefrontal-hippocampal theta connectivity reverses pain-related working-memory deficits". Paper presented in i3S Annual Meeting, 28-29 November 2019, Póvoa do Varzim, Portugal, 2019. Faria, Joana; Galhardo, Vasco; Monteiro, Clara; Cardoso-Cruz, Helder. "Optogenetic activation of corticostriatal circuitry revealed an important antinociceptive effect, but no significant impact in pain-related working memory deficits". Paper presented in i3S Annual Meeting, 28-29 November 2019, Póvoa do Varzim, Portugal, 2019. Faria, Joana; Paiva, Pedro; Galhardo, Vasco; Monteiro, Clara; Cardoso-Cruz, Helder. "Abnormal prefrontal-hippocampal connectivity supports pain-related working memory deficits". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience, 30 May - 1 June, Lisbon, PORTUGAL., 2019. Laranjeira, Inês; Paiva, Pedro; Monteiro, Clara; Cardoso-Cruz, Helder; Galhardo, Vasco. "Selective optogenetic inhibition of prelimbic excitatory neurons during delay-period reverses pain-related working memory deficits". Paper presented in XV Meeting of Portuguese Society for Neuroscience. May 25-26, Braga, PORTUGAL., 2017. Laranjeira, Inês; Galhardo, Vasco; Monteiro, Clara; Cardoso-Cruz, Helder. "Optogenetic modulation of the corticostriatal circuitry in chronic pain". Paper presented in IJUP - Investigação Jovem na Universidade do Porto, 8-10 February. Porto, PORTUGAL., 2017. Galhardo, Vasco; Cardoso-Cruz, Helder; Monteiro, Clara; Dourado, Margarida. "Orbitofrontal encoding of risk preference in a rodent gambling task of decision-making is modulated by dopamine D2/D3 receptors". Paper presented in 9th Congress of the European Federation of IASP Chapters (EFIC), Vienna, Austria, 2-5 September 2015., 2015. Monteiro, Clara; Cardoso-Cruz, Helder; Dourado, Margarida; Galhardo, Vasco. "Altered expression of dopamine receptors in hippocampus paralels the reduction in hippocampus functional connectivity in neuropathic rats". Paper presented in 9th Congress of the European Federation of IASP Chapters (EFIC), Vienna, Austria, 2-5 September 2015., 2015. Monteiro, Clara; Cardoso-Cruz, Helder; Dourado, Margarida; Lima, Deolinda; Galhardo, Vasco. "Decreased anxiety and enhanced fronto-hippocampal connectivity in the Prrxl1 knockout mouse model of congenital hypoalgesia". Paper presented in IBNS International Behavioral Neuroscience Society 24th Annual Meeting, Victoria, British Columbia, Canada, 2-7 June 2015, 2015. Galhardo, Vasco; Cardoso-Cruz, Helder; Monteiro, Clara; Dourado, Margarida. "Systemic modulation of dopamine D2/D3 receptors revert orbitofrontal neurophysiological neural correlates of risk preference in a rodent gambling task of decision-making under uncertainty". Paper presented in IBNS International Behavioral Neuroscience Society 24th Annual Meeting, Victoria, British Columbia, Canada, 2-7 June 2015., 2015. Paiva, Pedro; Cardoso-Cruz, Helder; Dourado, Margarida; Monteiro, Clara; Galhardo, Vasco. "Optogenetic inhibition of mPFC pyramidal population improves working memory performance in a delayed non-matching to sample task". Paper presented in XIV Meeting of the Portuguese Society for Neurosciences, 2015. Dourado, Margarida; Cardoso-Cruz, Helder; Paiva, Pedro; Monteiro, Clara; Galhardo, Vasco. "Activation of dopaminergic D2/D3 receptors reverses hippocampus-related working memory deficit induced by neuropathic pain". Paper presented in 4th Encontro de Doutorandos da Faculdade de Medicina da Universidade do Porto, 9 December 2014, Porto, PORTUGAL., 2014. Cardoso-Cruz, Helder; Dourado, Margarida; Raimundo, Mariana; Monteiro, Clara; Lima, Deolinda; Galhardo, Vasco. "Uncovering connectivity interactions between medial prefrontal cortex and mediodorsal thalamus in rats performing a spatial working memory task under an inflammatory pain condition". Paper presented in I3S - Scientific Retreat 2012, May 11-12, Póvoa de Varzim, PORTUGAL., 2012. Cardoso-Cruz, Helder; Monteiro, Clara; Lima, Deolinda; Galhardo, Vasco. "Dynamics of corticothalamic pain processing in freely behaving rats: a multi-electrode study". Paper presented in IX Reunião Anual da Sociedade Portuguesa de Neurociências, 2005, Luso, PORTUGAL., 2005. Lima, Deolinda; Cardoso-Cruz, Helder; Monteiro, Clara; Galhardo, Vasco. "Effect of the glycine receptor antagonist strychnine in the latency time responses of rat spinal dorsal horn neurons: a multielectrode study". Paper presented in 34th Annual Meeting of The Society for Neuroscience, San Diego, USA., 2004. Monteiro, Clara; Cardoso-Cruz, Helder; Galhardo, Vasco; Lima, Deolinda. "Intrathecal-strychnine administration promotes a decrease in latency time response of hyperexcited spinal dorsal horn neurons". Paper presented in Inaugural Symposium, International Institute for Neuroscience of Natal, March 3-7, 2004, Natal, BRAZIL., 2004. Cardoso-Cruz, Helder; Oliveira-Maia, Albino; Monteiro, Clara; Galhardo, Vasco; Lima, Deolinda. "Populational changes in rat anterior cingulate cortex neuronal network induced by pain". Paper presented in Inaugural Symposium, International Institute for Neuroscience of Natal, March 3-7, 2004, Natal, BRAZIL., 2004. Monteiro, Clara; Cardoso-Cruz, Helder; Lima, Deolinda; Galhardo, Vasco. "Indution of bistable activity and changes in the oscillatory properties of rat spinal dorsal horn neurons following formalin injection". Paper presented in FENS, Lisboa, PORTUGAL., 2004. Cardoso-Cruz, Helder; Monteiro, Clara; Lima, Deolinda; Galhardo, Vasco. "Effect of intrathecal administration of the glycine receptor antagonist strychnine in the latency time response of neurons in the rat spinal dorsal horn". Paper presented in FENS, Lisboa, PORTUGAL., 2004. Galhardo, Vasco; Monteiro, Clara; Cardoso-Cruz, Helder; Lima, Deolinda. "Pain-induced populational activity of somatosensory neurons in the rat anterior cingulate cortex". Paper presented in 33rd Annual Meeting of The Society for Neuroscience, New Orleans, USA., 2003.

Journal article

Cardoso-Cruz, Helder; Monteiro, Clara; Galhardo, Vasco. "Reorganization of lateral habenula neuronal connectivity underlies pain-related impairment in spatial memory encoding". Pain (2024): https://doi.org/10.1097/j.pain.0000000000003493. 10.1097/j.pain.0000000000003493 Cerqueira-Nunes, Mariana; Monteiro, Clara; Galhardo, Vasco; Cardoso-Cruz, Helder. "Orbitostriatal encoding of reward delayed gratification and impulsivity in chronic pain". Brain Research 1839 (2024): 149044. https://doi.org/10.1016/j.brainres.2024.149044. Open access • 10.1016/j.brainres.2024.149044 Cerqueira-Nunes, Mariana; Clara Monteiro; V. Galhardo; Cardoso-Cruz, H. "Deciphering the Role of the Nucleus Accumbens Shell Area on Spatial Memory Deficits Induced by Neuropathic Pain in Rats". Applied Biosciences (2024): https://www.mdpi.com/2813-0464/3/2/19. 10.3390/applbiosci3020019 Pereira, Ana Raquel; Alemi, Mobina; Cerqueira-Nunes, Mariana; Monteiro, Clara; Galhardo, Vasco; Cardoso-Cruz, Helder. Corresponding author: Cardoso-Cruz, Helder. "Dynamics of Lateral Habenula–Ventral Tegmental Area Microcircuit on Pain-Related Cognitive Dysfunctions". Neurology International 15 4 (2023): 1303-1319. http://dx.doi.org/10.3390/neurolint15040082. 10.3390/neurolint15040082 Rodrigues, Diogo; Monteiro, Clara; Cardoso-Cruz, Helder; Galhardo, Vasco. Corresponding author: Galhardo, Vasco. "Altered Brain Expression of DNA Methylation and Hydroxymethylation Epigenetic Enzymes in a Rat Model of Neuropathic Pain". International Journal of Molecular Sciences 24 8 (2023): 7305. http://dx.doi.org/10.3390/ijms24087305. Open access • 10.3390/ijms24087305 Alemi, Mobina; Pereira, Ana Raquel; Cerqueira-Nunes, Mariana; Monteiro, Clara; Galhardo, Vasco; Cardoso-Cruz, Helder. "Role of Glutamatergic Projections from Lateral Habenula to Ventral Tegmental Area in Inflammatory Pain-Related Spatial Working Memory Deficits". Biomedicines 11 3 (2023): 820. http://dx.doi.org/10.3390/biomedicines11030820. Open access • Published • 10.3390/biomedicines11030820 Cardoso-Cruz, Helder; Laranjeira, Inês; Monteiro, Clara; Galhardo, Vasco. "Altered prefrontal-striatal theta-band oscillatory dynamics underlie working memory deficits in neuropathic pain rats". European Journal of Pain 26 7 (2022): 1546-1568. http://dx.doi.org/10.1002/ejp.1982. Published • 10.1002/ejp.1982 Amaral-Pereira, Ana; Alemi, Mobina; Monteiro, Clara; Galhardo, Vasco; Cardoso-Cruz, Helder. Corresponding author: Cardoso-Cruz, Helder. "The role of lateral habenula - ventral tegmental area circuit in pain processing and cognitive functions.". (2022): Submitted Cardoso-Cruz, Helder; Paiva, Pedro; Monteiro, Clara; Galhardo, Vasco. "Bidirectional optogenetic modulation of prefrontal-hippocampal connectivity in pain-related working memory deficits". Scientific Reports 9 1 (2019): http://dx.doi.org/10.1038/s41598-019-47555-0. Published • 10.1038/s41598-019-47555-0 Monteiro, Clara; Cardoso-Cruz, Helder; Galhardo, Vasco. Corresponding author: Monteiro, Clara. "Animal models of congenital hypoalgesia: Untapped potential for assessing pain-related plasticity". Neuroscience Letters (2019): http://dx.doi.org/10.1016/j.neulet.2018.11.045. Published • 10.1016/j.neulet.2018.11.045 Cardoso-Cruz, Helder; Paiva, Pedro; Monteiro, Clara; Galhardo, Vasco. "Selective optogenetic inhibition of medial prefrontal glutamatergic neurons reverses working memory deficits induced by neuropathic pain". PAIN 160 4 (2019): 805-823. http://dx.doi.org/10.1097/j.pain.0000000000001457. 10.1097/j.pain.0000000000001457 Cardoso-Cruz, H.; Dourado, M.; Monteiro, C.; Galhardo, V.. "Blockade of dopamine D2 receptors disrupts intrahippocampal connectivity and enhances pain-related working memory deficits in neuropathic pain rats". European Journal of Pain (United Kingdom) 22 5 (2018): 1002-1015. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041040353&partnerID=MN8TOARS. 10.1002/ejp.1186 Monteiro, C.; Cardoso-Cruz, H.; Matos, M.; Dourado, M.; Lima, D.; Galhardo, V.. "Increased fronto-hippocampal connectivity in the Prrxl1 knockout mouse model of congenital hypoalgesia". Pain 157 9 (2016): 2045-2056. http://www.scopus.com/inward/record.url?eid=2-s2.0-84984605078&partnerID=MN8TOARS. 10.1097/j.pain.0000000000000611 Dourado, M.; Cardoso-Cruz, H.; Monteiro, C.; Galhardo, V.. "Effect of motor impairment on analgesic efficacy of dopamine D2/3 receptors in a rat model of neuropathy". Journal of Experimental Neuroscience 2016 10 (2016): 51-57. http://www.scopus.com/inward/record.url?eid=2-s2.0-85015234903&partnerID=MN8TOARS. 10.4137/JEn.s36492 Monteiro, C.; Dourado, M.; Matos, M.; Duarte, I.; Lamas, S.; Galhardo, V.; Lima, D.. "Critical care and survival of fragile animals: The case of Prrxl1 knockout mice". Applied Animal Behaviour Science 158 (2014): 86-94. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905904898&partnerID=MN8TOARS. 10.1016/j.applanim.2014.06.007 Cardoso-Cruz, H.; Dourado, M.; Monteiro, C.; Matos, M.R.; Galhardo, V.. "Activation of dopaminergic D2/D3 receptors modulates dorsoventral connectivity in the hippocampus and reverses the impairment of working memory after nerve injury". Journal of Neuroscience 34 17 (2014): 5861-5873. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899483174&partnerID=MN8TOARS. 10.1523/JNEUROSCI.0021-14.2014 Oliveira-Maia, A.J.; de Araujo, I.E.; Monteiro, C.; Workman, V.; Galhardo, V.; Nicolelis, M.A.L.. "The insular cortex controls food preferences independently of taste receptor signaling". Frontiers in Systems Neuroscience MARCH (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84857953762&partnerID=MN8TOARS. 10.3389/fnsys.2012.00005 Monteiro, C.; Rebelo, S.; Galhardo, V.; Reguenga, C.; Lima, D.. "Postnatal expression of the homeobox gene Prrxl1 (Drg11) is increased in inflammatory but not neuropathic pain". European Journal of Pain 15 5 (2011): 477-481. http://www.scopus.com/inward/record.url?eid=2-s2.0-79956137374&partnerID=MN8TOARS. 10.1016/j.ejpain.2010.10.007 Monteiro, C.; Lima, D.; Galhardo, V.. "Switching-on and -off of bistable spontaneous discharges in rat spinal deep dorsal horn neurons". Neuroscience Letters 398 3 (2006): 258-263. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646381137&partnerID=MN8TOARS. 10.1016/j.neulet.2006.01.008 Cardoso-Cruz, Helder; Monteiro, Clara; Lima, Deolinda; Galhardo, Vasco. "Efeito do antagonista do receptor de Glicina (Estricnina) no tempo de latência de resposta de neurónios da medula espinal de rato: Um estudo com multieléctrodos". DOR 12 (2004): 28-35. Published

Award

2017	Melhor Poster de “Neural Circuits and Behaviour”, XV Reunião da Sociedade Portuguesa de Neurociências Sociedade Portuguesa de Neurociências, Portugal
2015	Primeiro lugar do Prémio Dor 2014, Investigação Básica – Fundação Grunenthal
2013	Primeiro lugar do Prémio Dor 2012, Investigação Básica – Fundação Grunenthal
2004	Segundo lugar em Investigação Básica e Clínica da Dor 2004 – Fundação Grunenthal