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possui graduação magna cum laude em Ciências Biológicas pela Universidade Federal do Rio de Janeiro (2004), mestrado (2005) e doutorado (2009) em Química Biológica pela Universidade Federal do Rio de Janeiro, pós-doutorado no National Institute of Allergy and Infectious Diseases (NIAID/NIH) (2012), e pós-doutorado no Laboratório de termodinâmica de proteínas virais Gregório Weber (IBqM/UFRJ) (2009-2014) como bolsista Pós-doutorado Nota 10 da FAPERJ. Professora do Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro de 2014 a 2018. É Jovem Cientista do Nosso Estado FAPERJ desde 2018. É atualmente Professora Adjunta da Universidade Federal do Rio de Janeiro, onde orienta alunos de iniciação científica, mestrado e doutorado, como docente permanente do Programa de Pós graduação em Química Biológica. Tem experiência na área de bioquímica e biofísica, com ênfase em biologia estrutural de proteínas e glicobiologia, com foco no estudo das bases moleculares, terapia e diagnóstico das doenças neurodegenerativas.
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Identification

Personal identification

Full name
Tuane Cristine Ramos Gonçalves Vieira

Citation names

  • Vieira, Tuane
  • Vieira, TCRG
  • Vieira, TC

Author identifiers

Ciência ID
5517-AC2A-5F5E
ORCID iD
0000-0002-3574-5411

Email addresses

  • tcvieira@ualg.pt (Professional)

Telephones

Mobile phone
  • (*5521) 999920126 (Personal)

Addresses

  • Rua José Saramago, 30. 2J , 8005181, Montenegro, Faro, Portugal (Personal)

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology
  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Biophysics

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Proficiency (C2) Advanced (C1) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2005/08/01 - 2009/08/30
Concluded
 Química Biológica (Doctor)
Major in Bioquímica
Universidade Federal do Rio de Janeiro, Brazil
"Aspectos estruturais da interação entre a proteína do prion e heparina" (THESIS/DISSERTATION)
2000/02/01 - 2004/12/21
Concluded
 Ciências Biológicas (Licence)
Major in Licencitura
Universidade Federal do Rio de Janeiro, Brazil
2004/01/01 - 2004/01/01
Concluded
 Química Biológica (Master)
Major in Bioquímica
Universidade Federal do Rio de Janeiro, Brazil
"Estudo dos polissacarídeos sintetizados pelo caracol Achatina fulica Bowdich 1822: Estrutura, localização e biomineralização" (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution 		Employer
2013/01/01 - 2014/03/31 Postdoc (Research) Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro, Brazil
Universidade Federal do Rio de Janeiro, Brazil
2012/06/01 - 2012/12/31 Postdoc (Research) Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil
National Institute of Allergy and Infectious Disease Rocky Mountain Laboratories, United States
2009/09/01 - 2012/05/31 Postdoc (Research) Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro, Brazil
Universidade Federal do Rio de Janeiro, Brazil

Teaching in Higher Education

Category
Host institution 		Employer
2018/08/29 - Current Assistant Professor (University Teacher) Universidade Federal do Rio de Janeiro, Brazil
Universidade Federal do Rio de Janeiro, Brazil
2014/04/01 - 2018/08/28 Assistant Professor (University Teacher) Instituto Federal de Educação Ciência e Tecnologia do Rio de Janeiro, Brazil
Instituto Federal de Educação Ciência e Tecnologia do Rio de Janeiro, Brazil
Projects

Contract

Designation Funders
2024/01/01 - Current Prospecção de moduladores da agregação de proteínas em extratos de Moringa oleifera Lamarck para o tratamento de doenças neurodegenerativas
409103/2023-3
Principal investigator
Universidade Federal do Rio de Janeiro, Brazil
 Conselho Nacional de Desenvolvimento Científico e Tecnológico
2021/12/01 - Current Biologia Estrutural de Proteínas Envolvidas em Doenças Neurodegenerativas, Tumorais e Virais
408046/2021-0
Researcher
Universidade Federal do Rio de Janeiro, Brazil
 Conselho Nacional de Desenvolvimento Científico e Tecnológico
Ongoing
2021/07/01 - Current Dos mecanismos moleculares a terapia e diagnóstico em doenças neurodegenerativas: foco nas doenças priônicas
201.325/2021
Principal investigator
Universidade Federal do Rio de Janeiro, Brazil
 Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
Ongoing
2021/05/01 - Current Caracterização de compostos inibidores da agregação proteica: impacto nas doenças amiloidogênicas, câncer e formação de biofilmes
211.349/2021
Researcher
Universidade Federal do Rio de Janeiro, Brazil
 Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
Ongoing
2020/07/01 - Current Rede de Doenças Degenerativas e Câncer: da pesquisa básica ao diagnóstico molecular e terapias
211.559/2019
Researcher
Universidade Federal do Rio de Janeiro, Brazil
 Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
Ongoing
Outputs

Publications

Book chapter
  1. Vieira, TCRG. "Liquid-liquid phase transitions and amyloid aggregation in proteins related to cancer and neurodegenerative diseases". 289-331. Elsevier, 2019.
    10.1016/bs.apcsb.2019.08.002
Journal article
  1. Tuane C. R. G. Vieira; Caroline A. Barros; Renato Domingues; Tiago Fleming Outeiro. "PrP meets alpha-synuclein: Molecular mechanisms and implications for disease". Journal of Neurochemistry (2023): http://dx.doi.org/10.1111/jnc.15992.
    10.1111/jnc.15992
  2. Tiago F. Outeiro; Tuane C. R. G. Vieira. "AI and protein structure and function in neurological disease: relevance to disease management". Nature Reviews Neurology (2023): https://doi.org/10.1038/s41582-023-00840-z.
    10.1038/s41582-023-00840-z
  3. Silva JL; Foguel D; Ferreira VF; Vieira TCRG; Marques MA; Ferretti GDS; Outeiro TF; Cordeiro Y; de Oliveira GAP. "Targeting Biomolecular Condensation and Protein Aggregation against Cancer.". Chemical reviews (2023): http://europepmc.org/abstract/med/37379327.
    10.1021/acs.chemrev.3c00131
  4. Sousa Junior IP; Vieira TCRG. "Enterovirus infection and its relationship with neurodegenerative diseases.". Memorias do Instituto Oswaldo Cruz (2023): http://europepmc.org/abstract/med/36946853.
    10.1590/0074-02760220252
  5. Alves Conceição C; Assis de Lemos G; Barros CA; Vieira TCRG. "What is the role of lipids in prion conversion and disease?". Frontiers in molecular neuroscience (2023): http://europepmc.org/abstract/med/36704327.
    10.3389/fnmol.2022.1032541
  6. Amanda Rodrigues Pinto Costa; Marcelly Muxfeldt; Fernanda da Costa Santos Boechat; Maria Cecília Bastos Vieira de Souza; Jerson Lima Silva; Marcela Cristina de Moraes; Luciana Pereira Rangel; Tuane Cristine Ramos Gonçalves Vieira; Pedro Netto Batalha. "Aminoquinolones and Their Benzoquinone Dimer Hybrids as Modulators of Prion Protein Conversion". Molecules (2022): https://doi.org/10.3390/molecules27227935.
    10.3390/molecules27227935
  7. Magalhães RSS; Boechat FC; Brasil AA; Neto JRM; Ribeiro GD; Paranhos LH; Neves de Souza N; et al. "Hexokinase 2: The preferential target of trehalose-6-phosphate over hexokinase 1.". Journal of cellular biochemistry (2022): http://europepmc.org/abstract/med/35944097.
    10.1002/jcb.30317
  8. Jerson L. Silva; Tuane C. Vieira; Yraima Cordeiro; Guilherme A.P. de Oliveira. "Nucleic acid actions on abnormal protein aggregation, phase transitions and phase separation". Current Opinion in Structural Biology 73 (2022): 102346-102346. https://doi.org/10.1016/j.sbi.2022.102346.
    10.1016/j.sbi.2022.102346
  9. Vieira, TCRG. "Viral and Prion Infections Associated with Central Nervous System Syndromes in Brazil". Viruses 13 7 (2021): 1370-1370. http://dx.doi.org/10.3390/v13071370.
    10.3390/v13071370
  10. Vieira, TCRG. "Rabbit PrP Is Partially Resistant to in vitro Aggregation Induced by Different Biological Cofactors". Frontiers in Neuroscience 15 (2021): http://dx.doi.org/10.3389/fnins.2021.689315.
    10.3389/fnins.2021.689315
  11. Vieira, TCRG. "Phase separation of p53 precedes aggregation and is affected by oncogenic mutations and ligands". Chemical Science 12 21 (2021): 7334-7349. http://dx.doi.org/10.1039/d1sc01739j.
    10.1039/d1sc01739j
  12. Guilherme A. P. de Oliveira; Elaine C. Petronilho; Murilo M. Pedrote; Mayra A. Marques; Tuane Vieira; Elio A. Cino; Jerson L. Silva. "The Status of p53 Oligomeric and Aggregation States in Cancer". Biomolecules (2020): https://www.mdpi.com/2218-273X/10/4/548.
    10.3390/biom10040548
  13. Alencar Pires Barbosa, Breno Jose; Castrillo, Bruno Batitucci; Alvim, Ricardo Pires; de Brito, Marcelo Houat; Gomes, Helio R.; Brucki, Sonia M. D.; Smid, Jerusa; et al. "Second-Generation RT-QuIC Assay for the Diagnosis of Creutzfeldt-Jakob Disease Patients in Brazil". Frontiers in Bioengineering and Biotechnology (2020): https://publons.com/publon/33848847/.
    10.3389/FBIOE.2020.00929
  14. Ascari, Lucas M.; Rocha, Stephanie C.; Goncalves, Priscila B.; Vieira, Tuane C. R. G.; Cordeiro, Yraima. "Challenges and Advances in Antemortem Diagnosis of Human Transmissible Spongiform Encephalopathies". Frontiers in Bioengineering and Biotechnology (2020): https://publons.com/publon/36135533/.
    10.3389/FBIOE.2020.585896
  15. Tuane Cristine R. G. Vieira; Jerson L. Silva. "In Vitro Prion Amplification Methodology for Inhibitor Screening". Methods in molecular biology (Clifton, N.J.) (2019): https://publons.com/publon/18849365/.
    10.1007/978-1-4939-8820-4_20
  16. Cordeiro, Yraima; Vieira, Tuane; Kovachev, Petar S.; Sanyal, Suparna; Silva, Jerson L.. "Modulation of p53 and prion protein aggregation by RNA". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics (2019): https://publons.com/publon/18849364/.
    10.1016/J.BBAPAP.2019.02.006
  17. de Moraes, Marcela Cristina; Santos, Juliana Bosco; dos Anjos, Daniel Meira; Rangel, Luciana Pereira; Ramos Goncalves Vieira, Tuane Cristine; Moaddel, Ruin; da Silva, Jerson Lima. "Prion protein-coated magnetic beads: Synthesis, characterization and development of a new ligands screening method". Journal of Chromatography A (2015): https://publons.com/publon/3302686/.
    10.1016/J.CHROMA.2014.12.014
  18. Vieira, TCRG. "The aggregation of mutant p53 produces prion-like properties in cancer". Prion (2014): https://publons.com/publon/3302695/.
    10.4161/PRI.27776
  19. Tuane C. R. G. Vieira; Yraima Cordeiro; Byron Caughey; Jerson L. Silva. "Heparin binding confers prion stability and impairs its aggregation". The FASEB Journal (2014): https://publons.com/publon/12435355/.
    10.1096/FJ.13-246777
  20. Vieira, TCRG. "High-Pressure Chemical Biology and Biotechnology". Chemical Reviews (2014): https://publons.com/publon/12435351/.
    10.1021/CR400204Z
  21. Vieira, TCRG. "The role of RNA in mammalian prion protein conversion". Wiley Interdisciplinary Reviews: RNA (2012): https://publons.com/publon/11555901/.
    10.1002/WRNA.118
  22. Vieira, TCRG. "Heparin Binding by Murine Recombinant Prion Protein Leads to Transient Aggregation and Formation of RNA-Resistant Species". Journal of the American Chemical Society (2011): https://publons.com/publon/8094270/.
    10.1021/JA106725P
  23. Vieira, TCRG. "Experimental approaches to the interaction of the prion protein with nucleic acids and glycosaminoglycans: Modulators of the pathogenic conversion". Methods (2011): https://publons.com/publon/3302706/.
    10.1016/J.YMETH.2010.12.002
  24. Vieira, TCRG. "Ligand Binding and Hydration in Protein Misfolding: Insights from Studies of Prion and p53 Tumor Suppressor Proteins †". Accounts of Chemical Research (2010): https://publons.com/publon/10336575/.
    10.1021/AR900179T
  25. Vieira, TCRG. "PrP interactions with nucleic acids and glycosaminoglycans in function and disease". Frontiers in bioscience (Landmark edition) (2010): https://publons.com/publon/11555735/.
    10.2741/3611
  26. Vieira, TCRG. "Prion Protein Complexed to N2a Cellular RNAs through Its N-terminal Domain Forms Aggregates and Is Toxic to Murine Neuroblastoma Cells". Journal of Biological Chemistry (2008): https://publons.com/publon/11555860/.
    10.1074/JBC.M802102200
  27. Vieira, TCRG; Costa, A; Salgado, NC; Allodi, S; Valente, AP; Nasciutti, LE; Silva, LCF. "Acharan sulfate, the new glycosaminoglycan from Achatina fulica Bowdich 1822 - Structural heterogeneity, metabolic labeling and localization in the body, mucus and the organic shell matrix". European Journal of Biochemistry (2004): https://publons.com/publon/12851715/.
    10.1111/J.1432-1033.2004.03989.X