???global.info.a_carregar???
Maria Helena Rodrigues Macedo. Concluiu o(a) Mestrado em Mestrado Integrado em Engenharia Biomédica em 2016/12 pelo(a) Universidade do Minho Escola de Engenharia. Frequenta o(a) Doutoramento em Doutoramento em Ciências Biomédicas pelo(a) Universidade do Porto Instituto de Investigação e Inovação em Saúde desde 2017/09/01. Publicou 4 artigos em revistas especializadas. Possui 1 capítulo(s) de livros. Organizou 2 evento(s). Recebeu 2 prémio(s) e/ou homenagens. Nas suas atividades profissionais interagiu com 24 colaborador(es) em coautorias de trabalhos científicos.
Identification

Personal identification

Full name
Maria Helena Rodrigues Macedo

Citation names

  • Macedo, Maria Helena

Author identifiers

Ciência ID
531D-BAEA-1585
ORCID iD
0000-0003-4016-0562

Telephones

Telephone
  • 220408800 Ext.: 6103 (Professional)

Addresses

  • Rua Alfredo Allen, 4200-135, Paranhos, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine

Languages

Language Speaking Reading Writing Listening Peer-review
Spanish; Castilian Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2017/09/01 - 2021/12/15
Concluded
Doutoramento em Ciências Biomédicas (Doutoramento)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"New three-dimensional intestinal tissue engineering model as a multifunctional platform for drug and nanoparticle absorption studies" (THESIS/DISSERTATION)
2016/12
Concluded
Mestrado Integrado em Engenharia Biomédica (Mestrado)
Universidade do Minho Escola de Engenharia, Portugal
"The role of L-arginine in the modulation of oral biofilms in periodontal disease" (THESIS/DISSERTATION)
16
Affiliation

Science

Category
Host institution
Employer
2022/03/01 - Current Contracted Researcher (Research) International Iberian Nanotechnology Laboratory, Portugal
International Iberian Nanotechnology Laboratory, Portugal

Others

Category
Host institution
Employer
2020/11/01 - 2021/07/31 Visitor - Development of a part of the PhD work in a foreign institution Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Institut de Bioenginyeria de Catalunya, Spain
2017/01/09 - 2017/08/31 Research Trainee - Collaboration in research projects regarding the gastrointestinal tract and nanoparticle delivery systems Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016/02/29 - 2016/07/12 Internship in Risk Management - Adverse event analysis and development of several projects regarding the "Patients for patient" philosophy and and drug safety Hospital de Braga, Portugal
2015/09/14 - 2016/02/08 Erasmus+ Program - Development of a Master Thesis entitled "The role of L-arginine in the modulation of oral biofilms in periodontal disease". Supervisor: Professor Wim Teughels Co-supervisor: Profess Katholieke Universiteit Leuven, Belgium
2013/01/15 - 2013/04/15 Internship - Collaboration in the execution of laboratorial work regarding alginate and chitosan membranes for cardiovascular applications Biomaterials Biodegradables and Biomimetics, Portugal
Projects

Grant

Designation Funders
2017/09/01 - Current New three-dimensional intestinal tissue engineering model as multifunctional platform for drug and nanoparticle absorption studies
SFRH/BD/131587/2017
PhD Student Fellow
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Associação para a Inovação e Desenvolvimento da FCT
Ongoing
Outputs

Publications

Book chapter
  1. ALMEIDA, ANDREIA; Azevedo, Cláudia; Macedo, Maria Helena; Sarmento, Bruno. "3D intestinal models towards a more realistic permeability screening". In Nanotechnology for Oral Drug Delivery, 389-417. Elsevier, 2020.
    Published • 10.1016/b978-0-12-818038-9.00003-x
  2. ALMEIDA, ANDREIA; Macedo, Maria Helena; das Neves, José; Sarmento, Bruno. "CHAPTER 4. Thermo-responsive Nanomedicines for Drug Delivery in the Gastrointestinal Tract". In Stimuli-responsive Drug Delivery Systems, 83-108. Royal Society of Chemistry, 2018.
    Published • 10.1039/9781788013536-00083
Conference poster
  1. Macedo, Maria Helena. "We gut this: Innovative 3D bioengineered epithelium-stroma-epithelium in vitro intestinal model to perform reliable permeability studies". Paper presented in 4th PhDay: Break borders and build opportunities, 2021.
  2. Macedo, Maria Helena; Bruno Sarmento; Andreia Sofia Sousa Barros; Cristina Maria Santos Alves de Carvalho Barrias; Elena Martínez. "Innovative 3D multilayered intestinal in vitro model to perform reliable absorption studies". Paper presented in Current challenges and future perspectives in oral drug absorption research, 2021.
  3. Macedo, Maria Helena; Barros, Andreia; Martinez, Elena; Barrias, Cristina; Sarmento, Bruno. "Advanced multilayered 3D in vitro model to perform reliable drug permeability studies". Paper presented in 3rd SPLC-CRS Young Scientists Virtual Meeting, 2021.
  4. Macedo, Maria Helena; Martínez, Elena; Barrias, Cristina; Sarmento, Bruno. "Development of an improved 3D bioengineered in vitro intestinal model to assess paracellular permeability". Paper presented in 3rd PhDay - Back to the Future, 2020.
  5. Macedo, Maria Helena; Garcia, Andreia; Azevedo, Maria; Pestana, Manuel; Sarmento, Bruno; Sampaio-Maia, Benedita. "Effect of uremic state in in vitro Caco-2/HT29-MTX/Raji B intestinal epithelial model". Paper presented in IJUP - Encontro Investigação Jovem, 2020.
  6. Macedo, Maria Helena; Martínez, Elena; Barrias, Cristina; Sarmento, Bruno. "Development of an improved 3D intestinal model to study the permeability of paracellular compounds". Paper presented in XIIIth Spanish Portuguese Conference on Controlled Drug Delivery, 2020.
  7. Macedo, Maria Helena; Martínez, Elena; Barrias, Cristina; Sarmento, Bruno. "Development of an improved 3D intestinal model to study the permeability of paracellular compounds". Paper presented in 2º Encontro de Estudantes do Doutoramento em Ciências Biomédicas do ICBAS, 2019.
  8. Macedo, Maria Helena; Martínez, Elena; Barrias, Cristina; Sarmento, Bruno. "3D bioengineered small intestine for drug absorption studies". Paper presented in 8th i3S Annual Meeting, 2019.
  9. Macedo, Maria Helena; Martinez, Elena; Barrias, Cristina; Sarmento, Bruno. "3D bioengineered small intestine for drug absorption studies". Paper presented in 2nd PhD at i3s, 2019.
  10. Macedo, Maria Helena; Martínez, Elena; Barrias, Cristina; Sarmento, Bruno. "Studying the adhesion of epithelial cells to collagen hydrogels to develop a new 3D intestinal model". Paper presented in 2nd SPLC-CRS Young Scientist Meeting, 2019.
  11. Macedo, Maria Helena; Martínez, Elena; Barrias, Cristina; Sarmento, Bruno. "New three-dimensional intestinal tissue engineering model as a multifunctional platform for drug and nanoparticle absorption studies". Paper presented in 3rd International Conference on Biological and Biomimetic Adhesives (ICBBA 2018), 2018.
  12. Macedo, Maria Helena; Martinez, Elena; Barrias, Cristina; Sarmento, Bruno. "New three-dimensional intestinal tissue engineering model as a multifunctional platform for drug and nanoparticle absorption studies". Paper presented in 1st PhDay at i3s– From bench to stage, from desk to forum, 2018.
  13. Macedo, Maria Helena; Oliveira Sílvia; Martins Ana Catarina. "Uso de colete para a diminuição de erros de medicação". Paper presented in I Jornadas de Enfermagem de Neurocirurgia do Hospital de Braga, 2016.
Journal article
  1. Macedo, Maria Helena; Andreia Sofia Sousa Barros; Cristina Maria Santos Alves de Carvalho Barrias; Elena Martínez; Bruno Sarmento. Corresponding author: Bruno Sarmento. "All layers matter: Innovative three-dimensional epithelium-stroma-endothelium intestinal model for reliable permeability outcomes". Journal of Controlled Release 341 (2021): 414-430. https://doi.org/10.1016/j.jconrel.2021.11.048.
    Published
  2. Macedo, Maria Helena. "Mucus-producing 3D cell culture models". Advanced Drug Delivery Reviews 178 (2021): 113993-113993. http://dx.doi.org/10.1016/j.addr.2021.113993.
    10.1016/j.addr.2021.113993
  3. Castro, Flávia; Leite Pereira, Catarina; Helena Macedo, Maria; Almeida, Andreia; Silveira, Maria José (BA1E-7E7A-B4DA); Dias, Sofia; Patrícia Cardoso, Ana; Oliveira, Maria José (B41B-88E4-A903); Sarmento, Bruno. "Advances on colorectal cancer 3D models: The needed translational technology for nanomedicine screening". Advanced Drug Delivery Reviews 175 (2021): 113824. http://dx.doi.org/10.1016/j.addr.2021.06.001.
    Accepted • 10.1016/j.addr.2021.06.001
  4. Azevedo, Cláudia; Macedo, Maria Helena; Almeida, Andreia; Pinto, Soraia; van Loon, Jack J.W.A.; Sarmento, Bruno. "The effect of hypergravity in intestinal permeability of nanoformulations and molecules". European Journal of Pharmaceutics and Biopharmaceutics 163 (2021): 38-48. http://dx.doi.org/10.1016/j.ejpb.2021.03.013.
    10.1016/j.ejpb.2021.03.013
  5. Macedo, Maria Helena; Martínez Elena; Barrias, Cristina; Sarmento, Bruno. "Development of an improved 3D in vitro intestinal model to perform permeability studies of paracellular compounds". Frontiers in Bioengineering and Biotechnology 8 524018 (2020): https://www.frontiersin.org/articles/10.3389/fbioe.2020.524018/full.
    Open access • Published • https://doi.org/10.3389/fbioe.2020.524018
  6. Jaradat Abdolelah; Macedo, Maria Helena; Sousa, Flávia; Arkill Kenton; Alexander, Cameron; Aylott, Jonathan; Sarmento, Bruno. "Prediction of the enhanced insulin absorption across a triple co-cultured intestinal model using mucus penetrating PLGA nanoparticles". International Journal of Pharmaceutics 585 119516 (2020): http://dx.doi.org/10.1016/j.ijpharm.2020.119516.
    Published • 10.1016/j.ijpharm.2020.119516
  7. Garcia, Andreia; Macedo, Maria Helena; Azevedo, Maria; Pestana, Manuel; Sarmento, Bruno; Sampaio-Maia, Benedita. "Effect of uremic state in intestine through a co-culture in vitro intestinal epithelial model". International Journal of Pharmaceutics 594 119450 (2020): https://www.sciencedirect.com/science/article/pii/S0378517320304348.
    Published • 10.1016/j.ijpharm.2020.119450
  8. Beconcini Denise; Felice Francesca; Zambito Ylenia; Fabiano Angela; Piras Anna Maria; Macedo, Maria Helena; Sarmento, Bruno; Di Stefano Rossella. "Anti-Inflammatory Effect of Cherry Extract Loaded in Polymeric Nanoparticles: Relevance of Particle Internalization in Endothelial Cells". Pharmaceutics 11 10 (2019): 500. http://dx.doi.org/10.3390/pharmaceutics11100500.
    Published • 10.3390/pharmaceutics11100500
  9. Eliyahu, Shaked; ALMEIDA, ANDREIA; Macedo, Maria Helena; das Neves, José; Sarmento, Bruno; Bianco-Peled Havazelet. "The effect of freeze-drying on mucoadhesion and transport of acrylated chitosan nanoparticles". International Journal of Pharmaceutics 573 (2019): 118739. http://dx.doi.org/10.1016/j.ijpharm.2019.118739.
    Published • 10.1016/j.ijpharm.2019.118739
  10. Beconcini Denise; Fabiano Angela; Di Stefano Rossella; Macedo, Maria Helena; Felice Francesca; Zambito Ylenia; Sarmento, Bruno. "Cherry Extract from Prunus avium L. to Improve the Resistance of Endothelial Cells to Oxidative Stress: Mucoadhesive Chitosan vs. Poly(lactic-co-glycolic acid) Nanoparticles". International Journal of Molecular Sciences 20 7 (2019): 1759. http://dx.doi.org/10.3390/ijms20071759.
    Published • 10.3390/ijms20071759
  11. Lin, Kaili; Zhang, Dawei; Macedo, Maria Helena; Cui, Wenguo; Sarmento, Bruno; Shen, Guofang. "Advanced Collagen-Based Biomaterials for Regenerative Biomedicine". Advanced Functional Materials 29 3 (2018): 1804943. http://dx.doi.org/10.1002/adfm.201804943.
    Published • 10.1002/adfm.201804943
  12. Macedo, Maria Helena; Araújo, Francisca; Martínez, Elena; Barrias, Cristina; Sarmento, Bruno. "iPSC-Derived Enterocyte-like Cells for Drug Absorption and Metabolism Studies". Trends in Molecular Medicine 24 8 (2018): 696-708. http://dx.doi.org/10.1016/j.molmed.2018.06.001.
    Published • 10.1016/j.molmed.2018.06.001
  13. Sonia Pinho; Maria H. Macedo; Catarina Rebelo; Bruno Sarmento; Lino Ferreira. "Stem cells as vehicles and targets of nanoparticles". Drug Discovery Today 23 5 (2018): 1071-1078. https://doi.org/10.1016%2Fj.drudis.2018.01.030.
    10.1016/j.drudis.2018.01.030
  14. Azevedo, C.; Macedo, M.H.; Sarmento, B.. "Strategies for the enhanced intracellular delivery of nanomaterials". Drug Discovery Today (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85030151565&partnerID=MN8TOARS.
    10.1016/j.drudis.2017.08.011
Thesis / Dissertation
  1. Macedo, Maria Helena. "The role of L-arginine in the modulation of oral biofilms in periodontal disease". Master, Universidade do Minho, 2016. http://repositorium.sdum.uminho.pt/handle/1822/46534.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/12/02 Avanços em Engenharia de Tecidos: Tecido Intestinal II Congresso (virtual) Brasileiro em Engenharia de Tecidos
TissueLabs (Brasilia, Brazil)
2021/10/13 We GUT this: A bioengineered 3D in vitro intestinal model to perform reliable drug permeability studies Young Scientists Seminar
Instituto de Investigação e Inovação em Saúde (Porto, Portugal)
2021/09/06 Advanced multilayered three-dimensional epithelium-stroma-endothelium in vitro intestinal model to perform reliable drug permeability studies 31st Conference of the European Society for Biomaterials
European Society for Biomaterials (Porto)
2021/07/26 Innovative three-dimensional epithelium-stroma-endothelium intestinal model for reliable permeability outcomes Controlled Release Society 2021 Virtual Annual Meeting
Controlled Released Society
2020/12/09 Novel three-dimensional multilayer bioengineered in vitro model to perform reliable epithelial-endothelial permeability studies I Congresso (Virtual) Brasileiro de Engenharia de Tecidos
TissueLabs (São Paulo, Brazil)
2020/06/30 Development of novel three-dimensional bioengineered biorelevant in vitro intestinal model to screen paracellular permeability Controlled Released Society Virtual Meeting: 2020 Vision for global impact
Controlled Released Society (United States)
2019/09/18 3D bioengineered small intestine for drug absorption studies New Frontier in Biofabrication: From Biomolecules to Tissues and Organs
KU Leuven (Leuven, Belgium)
2019/07/22 New Three-dimensional Intestinal Tissue Engineering Model As Multifunctional Platform For Drug And Nanoparticle Absorption Studies Controlled Release Society Annual Meeting & Exposition
Controlled Release Society (Valência, Spain)
2019/06/28 3D bioengineered intestine for drug screening absorption studies Interrogations at the biointerface
i3s - Instituto de Investigação e Inovação em Saúde (Porto, Portugal)
2019/03/14 Um Engenheiro Biomédico na Investigação Ciêntifica - A importância da nossa versatilidade  II Jornadas de Engeharia Biomédica
Universidade de Trás-os-Montes e Alto Douro (Vila Real, Portugal)

Event organisation

Event name
Type of event (Role)
Institution / Organization
2021/03 - 2021/05/03 Social event - Online quiz for the propagation of the Transdermal and Mucosal Delivery focus group and its social media pages (2021/05/03 - 2021/05/03)
Other (Co-organisor)
Controlled Release Society, United States
2018/01/02 - 2018/05/30 1st PhDay at i3S – From bench to stage, from desk to forum. The first PhDay to take place at i3S had several scientific and ludic activities. PhD students from i3S had the chance to present their work, either in the form of oral or poster presentation, to the scientific community. Besides, students could share their knowledge, get new insights about their work and start new collaborations. (2018/05/30)
Conference (Member of the Organising Committee)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017/11 - 2018/05/16 Pint of Science - The Pint of Science is an international science festival that was established by a community of postgraduate and postdoctoral researchers in 2012. It happened for the first time in Portugal in 2018. This festival aims to deliver interesting and relevant talks on the latest science research in an accessible format to the public – mainly across bars and pubs and allows people to discuss research with the people who carry it out and no prior knowledge of the subject is required (2018/05/14 - 2018/05/16)
Festival (Member of the Organising Committee)

Event participation

Activity description
Type of event
Event name
Institution / Organization
2021/11/05 - 2021/11/06 i-Days promote health innovation among university students through dozens of one-day and two-day programmes held in academic institutions around Europe. Students from all academic areas receive an introduction to practical health innovation tools and compete in teams to tackle real-life health challenges posed by EIT Health, local organisations, private corporations or start-ups. The winning team of each i-Day will attend the Winners’ Event, a final competition that unites students from around Europe.
Call
I-Days
Universidade do Porto, Portugal

EIT Health, Germany
2021/09/06 - 2021/09/10 The purpose of Porto for Talent Summer Academy is to create contact opportunities between high education students and companies within the North of Portugal, through site visit and conversations with professionals.
Other
Porto for Talent Summer Academy
Universidade do Porto, Portugal
2020/10 - 2021/07 Course on the Fundamentals of Bioethics and Research Ethics, Good Research/er: what it is and why it matters, Preventing and Managing Conflicts: Communication and Decision Making, Authorship Issues, Plagiarism, Self-Plagiarism and Questionable Practices, Data Management/Manipulation, Privacy, Confidentiality and Data Protection, Biobanks and Genomic Research, Human Research Ethics, Vulnerabilty and Equity in Human Research | Integrity and Ethics in, Animal Research, Mentor and Mentee responsibilities; Career Development
Workshop
Research Ethics & Integrity Course
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021/05/22 - 2021/05/22 LYRIS selected a group of top-worldwide doctoral professionals as speakers from non-academic careers and you will have the chance to listen their career pathways, what that career involves and how to achieve it.
Workshop
How to be a successful PhD outside of academia
Lyris School, Portugal
2020/01/28 - 2020/11/30 The Spin Your Thesis! (SYT) programme offers university students (bachelor, master and PhD levels) the opportunity to perform scientific or technological research in hypergravity conditions in a number of fields such as biology, biochemistry, microbiology, optical physics, material sciences, fluid dynamics, geology and plasma physics.
Call
Spin Your Thesis
European Space Agency, France
2020/11/02 - 2020/11/06 Workshopt about organoids models in cancer, infectious diseases and regenerative medicine, Stem cells and microenvironment in organoid cultures, 3D in vitro models for biomedicine applications and Hands-on training in intestinal organoids (isolation and culture).
Workshop
Organoids and Advanced 3D in Vitro Models for Research in Health and Disease
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2020/05 - 2020/05 Course about the important points that should be considered when submitting articles to journals, with focus on authorship criteria, issues related to conflict of interest, and manuscript submissions systems used by popular publishers.
Workshop
How to Submit a Journal Article and Get it Published
Enago, United States
2020/05 - 2020/05 Course focusing on the preliminary aspects that any researcher should focus when he/she intends to begin writing any research paper that eventually will be submitted to an international peer-reviewed journal.
Workshop
How to Write an Effective Research Paper
Enago, United States
2019/12/16 - 2019/12/18 This training school aimed to provide participants with the basic understanding of regression, model construction, evaluation, and simulation. Concepts were explained through practical applications to experimental data from permeability studies and dissolution assays (in standard and novel apparatus) and the link to in vivo plasma profiles.
Workshop
Basics of data modelling application to permeability studies and in vitro in vivo correlations
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidad Miguel Hernández de Elche, Spain

European Cooperation in Science and Technology, Belgium
2019/09/05 - 2019/09/27 The objectives of the 1st Discoveries Entrepreneurship Prize are to cultivate an entrepreneurial culture in the field of Regenerative and Precision Medicine, select innovative business ideas, in the field of Regenerative and Precision Medicine, around which the creation of new innovation-intensive companies with potential for growth and commercial viability are envisaged and support the realization of high potential business ideas.
Call
1st Discoveries Entrepreneurship Prize
Universidade do Minho, Portugal

Laboratório Associado ICVS 3B's, Portugal
2019/03/12 - 2019/09/12 Fuel - A program to give early-stage entrepreneurs the right energy, conditions and network to make great ideas blossom.
Call
Fuel
International Iberian Nanotechnology Laboratory, Portugal
2018/11/05 - 2018/11/09 Learn fundamental aspects in the design and development of bio-inspired polymers and hydrogels. The training school consisted in the synthesis or modification of macromolecules, their physico-chemical characterization (including mechanical testing), the processing of materials (multilayered systems, hydrogels, particles…) and biological testing to access cell response to the developed systems.
Workshop
Bioinspired adhesive polymers and hydrogels
Universidade de Aveiro, Portugal

European Cooperation in Science and Technology, Belgium
2018/03/16 - 2018/04/17 Prémio Norte Empreendedor wishes to award entrepreneurs and encourage the creation of new startups in the North of Portugal.
Call
Prémio Norte Empreendedor

Committee member

Activity description
Role
Institution / Organization
2020/10 - Current Students representative in the Transdermal and Mucosal Delivery Focus Group from the Controlled Release Society
Member
Controlled Release Society, United States
2019/09 - 2020/09 Young Scientists Seminar (YSS): Organization of weekly seminars with PhD projects developed at i3S
Member
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Conference scientific committee

Conference name Conference host
2021/03 - 2021/03 2021 CRS Virtual Annual Meeting Virtual
Distinctions

Award

2020 Video Contest Award
Controlled Release Society, United States
2020 Best poster award at the 3rd PhDay at i3s - Back to the Future
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2020 Best oral presentation at I Congresso (Virtual) Brasileiro de Engenharia de Tecidos
TissueLabs, Brazil
2019 Mind-mapping championship award
Controlled Release Society, United States
2018 Prémio Norte Empreendedor
2016 First place in a E-poster contest of the I Conference of Neurosurgery Nursing
Hospital de Braga, Portugal