Ana Cláudia Bernardino Raposo (5319-3EE3-36F3)

Curriculum Vitae

Ana Cláudia Bernardino Raposo

Ana Cláudia Bernardino Raposo. Atua na(s) área(s) de Ciências Naturais com ênfase em Ciências Biológicas com ênfase em Biologia Celular. No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: Cromossoma X; XCI; XIST; Erosion; .

Identification

Personal identification

Full name: Ana Cláudia Bernardino Raposo

Citation names

Raposo, Ana Cláudia

Author identifiers

Ciência ID: 5319-3EE3-36F3

Email addresses

ana.c.raposo@tecnico.ulisboa.pt (Professional)

Knowledge fields

Natural sciences - Biological Sciences - Cell Biology

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
English	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)

Education

	Degree	Classification
2018/12/01 - 2023/01/31 Ongoing	Ciências Biomédicas (Doutoramento) Major in Biologia Celular e Molecular Instituto de Medicina Molecular João Lobo Antunes, Portugal
2011 Concluded	Molecular Biology and Genetics (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal "The role of Histone H3 trimethylation on transcription" (THESIS/DISSERTATION)	17 (out of 20)
2009 Concluded	Biologia (Licenciatura) Universidade de Lisboa Instituto Superior de Agronomia, Portugal "n/a" (THESIS/DISSERTATION)	14 (out of 20)

Affiliation

Science

	Category Host institution	Employer
2016/12/01 - 2018/11/30	Researcher (Research)	Instituto de Medicina Molecular João Lobo Antunes, Portugal

2013/01/01 - 2014/04/30	Researcher (Research)	Universidade de Lisboa Instituto Superior de Agronomia, Portugal

2012/08/01 - 2012/12/31	Researcher (Research)	Universidade de Lisboa Instituto Superior de Agronomia, Portugal

Others

	Category Host institution	Employer
2018/12/01 - Current	PhD student	Instituto de Medicina Molecular João Lobo Antunes, Portugal
	Universidade de Lisboa Faculdade de Medicina, Portugal
2016 - 2018/11/30	Lab manager	Instituto de Medicina Molecular João Lobo Antunes, Portugal

2015/10/01 - 2016/11/30	Administrative	Hospital da Luz Lisboa, Portugal

2015/05/01 - 2015/09/30	Maternity leave	Instituto de Medicina Molecular João Lobo Antunes, Portugal

2014/05/01 - 2015/04/30	Lab manager	Instituto de Medicina Molecular João Lobo Antunes, Portugal

2011/12/01 - 2012/07/31	IEFP traineeship *IEFP - Instituto do Emprego e Formação Profissional	Instituto de Medicina Molecular João Lobo Antunes, Portugal

2010 - 2011	Tese de mestrado	Instituto de Medicina Molecular João Lobo Antunes, Portugal

Projects

Grant

	Designation	Funders
2018/12/01 - Current	Functional dissection of the XIST non-coding RNA in X-chromosome inactivation in human ESCs SFRH/BD/137099/2018 PhD Student Fellow Instituto de Medicina Molecular João Lobo Antunes, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2016/12/01 - 2018/11/30	Investigação da dinâmica dos processos epigenéticos envolvendo RNAs não codificantes durante o processo de reprogramação em células estaminais induzidas PTDC/BEX-BMC/2612/2014 Research Fellow Instituto de Medicina Molecular João Lobo Antunes, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2014/05/01 - 2015/04/30	Decrypting SRF/MRTF-regulated transcriptome in endothelial tip cells EXPL/BEX-BCM/2258/2013 Instituto de Medicina Molecular João Lobo Antunes, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2013/01/01 - 2014/04/30	Characterization of Reproductive Development of Quercus suber PTDC/AGR-GPL/118508/2010 Universidade de Lisboa Instituto Superior de Agronomia, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2012/08/01 - 2012/12/31	Agronomic, physiological and molecular assessment of signaling in seedless grapes induced for flower/fruitlet abscission PTDC/AGR-GPL/116923/2010 Research Fellow Universidade de Lisboa Instituto Superior de Agronomia, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Other

	Designation	Funders
2011/12/01 - 2012/07/31	SETD2 mediates a novel tumor suppressor mechanism that is misregulated in clear cell renal carcinoma PTDC-BIA-BCM-111451-2009 Instituto de Medicina Molecular João Lobo Antunes, Portugal	Fundação para a Ciência e a Tecnologia
2010/09/01 - 2011/09/22	The role of histone H3 trimethylation on transcription N/A Other

Outputs

Publications

Journal article

Raposo, Ana Cláudia; Casanova, Miguel; Gendrel, Anne-Valerie; da Rocha, Simão Teixeira. "The tandem repeat modules of Xist lncRNA: a swiss army knife for the control of X-chromosome inactivation". Biochemical Society Transactions 49 6 (2021): 2549-2560. http://dx.doi.org/10.1042/bst20210253.
10.1042/bst20210253
Arez, Maria; Eckersley-Maslin, Melanie; Klobucar, Tajda; von Gilsa-Lopes, João; Krueger, Felix; Raposo, Ana Cláudia; Gendrel, Anne-Valerie; Bernardes de Jesus, Bruno; da Rocha, Simão T.. "Sex of donor cell and reprogramming conditions predict the extent and nature of imprinting defects in mouse iPSCs". Nature Communications (2021): https://www.biorxiv.org/content/10.1101/2020.11.20.370973v1.
Under revision
Silva, Teresa P.; Pereira, Carolina A.; Raposo, Ana Cláudia; Oliveira, Ana Rita; Arez, Maria; Cabral, Joaquim M.S.; Milagre, Inês; Carmo-Fonseca, Maria; Rocha, Simão Teixeira da. "Generation and characterization of induced pluripotent stem cells heterozygous for the Portuguese BRCA2 founder mutation". Stem Cell Research 53 (2021): 102364. http://dx.doi.org/10.1016/j.scr.2021.102364.
Accepted • 10.1016/j.scr.2021.102364
Silva, Teresa P.; Pereira, Carolina A.; Oliveira, Ana Rita; Raposo, Ana Cláudia; Arez, Maria; Cabral, Joaquim M.S.; Milagre, Inês; Carmo-Fonseca, Maria; da Rocha, Simão T.. "Generation and characterization of induced pluripotent stem cells from a family carrying the BRCA1 mutation c.3612delA". Stem Cell Research 52 (2021): 102242. http://dx.doi.org/10.1016/j.scr.2021.102242.
10.1016/j.scr.2021.102242
Tjalsma, Sjoerd J D; Hori, Mayako; Sato, Yuko; Bousard, Aurelie; Ohi, Akito; Raposo, Ana Cláudia; Roensch, Julia; et al. "H4K20me1 and H3K27me3 are concurrently loaded onto the inactive X chromosome but dispensable for inducing gene silencing". EMBO reports (2021): http://dx.doi.org/10.15252/embr.202051989.
Published • 10.15252/embr.202051989
Bousard, Aurélie; Raposo, Ana Cláudia; Zylicz, Jan Jakub; Picard, Christel; Pires, Vanessa Borges; Qi, Yanyan; Gil, Cláudia; et al. "The role of Xist -mediated Polycomb recruitment in the initiation of X-chromosome inactivation". EMBO reports 20 10 (2019): http://dx.doi.org/10.15252/embr.201948019.
10.15252/embr.201948019
Pólvora-Brandão, Duarte; Joaquim, Mariana; Godinho, Inês; Aprile, Domenico; Álvaro, Ana Rita; Onofre, Isabel; Raposo, Ana Cláudia; et al. "Loss of hierarchical imprinting regulation at the Prader–Willi/Angelman syndrome locus in human iPSCs". Human Molecular Genetics (2018): http://dx.doi.org/10.1093/hmg/ddy274.
10.1093/hmg/ddy274
Domingos, Sara; Nobrega, Hugo; Raposo, Ana; Cardoso, Vânia; Soares, Isabela; Ramalho, José C.; Leitão, António E.; Oliveira, Cristina M.; Goulao, Luis F.. "Light management and gibberellic acid spraying as thinning methods in seedless table grapes (Vitis vinifera L.): Cultivar responses and effects on the fruit quality". Scientia Horticulturae 201 (2016): 68-77. http://dx.doi.org/10.1016/j.scienta.2016.01.034.
10.1016/j.scienta.2016.01.034
Carvalho, Sílvia; Vítor, Alexandra C; Sridhara, Sreerama C; Martins, Filipa B; Raposo, Ana C; Desterro, Joana MP; Ferreira, João; de Almeida, Sérgio F. "SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint". eLife 3 (2014): http://dx.doi.org/10.7554/elife.02482.
10.7554/elife.02482
Carvalho, Sílvia; Raposo, Ana Cláudia; Martins, Filipa Batalha; Grosso, Ana Rita; Sridhara, Sreerama Chaitanya; Rino, José; Carmo-Fonseca, Maria; de Almeida, Sérgio Fernandes. "Histone methyltransferase SETD2 coordinates FACT recruitment with nucleosome dynamics during transcription". Nucleic Acids Research 41 5 (2013): 2881-2893. http://dx.doi.org/10.1093/nar/gks1472.
Published • 10.1093/nar/gks1472

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2019/10/11	Stability of X-chromosome inactivation in female hiPSCs	11th International Meeting of the Portuguese Society for Stem Cell and Cell Therapies Faculdade de Farmácia Universidade de Lisboa (Lisboa, Portugal)
2019/05/16	Functional dissection of the XIST non-coding RNA in X-chromosome inactivation in human ESCs	XIII Annual CAML PhD Students Meeting (Lisboa, Portugal)
2019/01/24	Exploring the role of Polycomb recruitment in Xist-mediated silencing of the X chromosome in ES cells	VIII National RNA Meeting 2019 (Porto, Portugal)
2013/07/24	SET domain proteins in Quercus suber: Identification and expression during flowering development	XIII Congresso Luso-Espanhol de Fisiologia Vegetal Faculdade de Ciências da Universidade de Lisboa (Lisboa, Portugal)
2012/01/26	Methylated histone H3 Lys 36 cooperates with SUPT16H and SSRP1 to maintain nucleosome integrity during transcription	RNA Meeting Instituto de Medicina Molecular João Lobo Antunes (Lisboa, Portugal)