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Alexandre da Costa Oliveira completed the Master's degree in Chemistry in 2016 by the Faculty of Science and Technology at the University of Coimbra with a final degree mark of 18/20 and a bachelor's degree in Medicinal Chemistry in 2013 by the Faculty of Science and Technology at the University of Coimbra with a final degree mark of 16/20. Attends the Ph.D. in Chemistry with a specialization in Biological Chemistry by the Faculty of Science and Technology at the University of Coimbra since 2017 with a Ph.D. grant supported by the Fundação para Ciência e Tecnhologia, Portugal (SFRH/BD/120934/2016). During his Ph.D. was a visiting student at the Prof. Gregory Voth group at the University of Chicago, with a Fulbright scholarship. Published 4 articles in international journals. Organized 2 event(s). Works in the area(s) Medicinal Chemistry and Biophysics.
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Identification

Personal identification

Full name
Alexandre da Costa Oliveira
Date of birth
1991/02/18
Gender
Male

Citation names

  • Oliveira, Alexandre C.

Author identifiers

Ciência ID
4F17-5D8D-022A
ORCID iD
0000-0001-7920-7773

Email addresses

  • ac_oliveira10@hotmail.com (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry
  • Natural sciences - Biological Sciences - Biophysics

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French (Mother tongue)
Education
Degree Classification
2017/09/01 - 2022
Ongoing
 Chemistry (Doutoramento)
Major in Biological Chemistry
Faculty of Science and Technology at the University of Coimbra, Portugal
"A Rational Approach to the Enhancement of Brain Availability of Imaging Probes" (THESIS/DISSERTATION)
2013/09/15 - 2016/02/26
Concluded
 Chemistry (Mestrado)
Major in Specialization in Advanced and Industrial Chemistry
Faculty of Science and Technology at the University of Coimbra, Portugal
"Caracterização Físico-Química de complexos de iões de lantanídeos conjugados com PiB e sua interacção com agregados Aß(1 40)" (THESIS/DISSERTATION)
 18
2010 - 2013
Concluded
 Medicinal Chemistry (Licenciatura)
Faculty of Science and Technology at the University of Coimbra, Portugal
"Agregação dos Péptidos ß Amilóides 1-28 e 1-40 e sua Associação com a Sonda AML3 Monitorizadas por Dicroísmo Circular e Fluorescência da sonda Tioflavina-T" (THESIS/DISSERTATION)
 16
Affiliation

Science

Category
Host institution 		Employer
2017 - Current Researcher (Research) PhD grant supported by the Fundação para Ciência e Tecnhologia, Portugal (SFRH/BD/120934/2016), Portugal
Coimbra Chemistry Center at the department of Chemistry of the Faculty of Science and Technology at the University of Coimbra, Portugal

Others

Category
Host institution 		Employer
2021/06/30 - 2021/10/31 Fulbright Scholarship Program at the Prof. Gregory Voth group University of Chicago Department of Chemistry, United States
2015/02/15 - 2015/04/15 Visiting Young Scientist (STSM-COST) in Metal Complexes for Biomedical Applications Centre de Biophysique Moléculaire, France
Centre de Biophysique Moléculaire, France
Projects

Other

Designation Funders
2021/01/01 - 2021/12/31 In Silico Optimization of Brain Imaging Probes with Enhanced Permeation
CPCA/A2/7181/2020
Researcher
Fundacao para a Computacao Cientifica Nacional
Concluded
Outputs

Publications

Conference poster
  1. Alexandre C. Oliveira; Hugo A. L. Filipe; Armindo Salvador; Rui Sun; Gregory A. Voth; Carlos F. G. C. Geraldes; Maria João Moreno; Luís M. S. Loura. "Modelling Gd-DOTA for molecular dynamics simulations in water and in presence of lipid bilayers". Paper presented in Encontro de Jovens Investigadores de Biologia Computacional Estrutural, 2021.
  2. Alexandre C. Oliveira; Hugo A. L. Filipe; Armindo Salvador; Rui Sun; Gregory A. Voth; Carlos F. G. C. Geraldes; Maria João Moreno; Luís M. S. Loura. "Modelling Gd-DOTA for molecular dynamics simulations in water and in presence of lipid bilayers". Paper presented in Coimbra Chemistry Center Day 2021, 2021.
  3. Oliveira, Alexandre; Morfin, Jean-François; Tóth, Éva; Costa, Telma C.; Justino, Licínia L.G.; Burrows, Hugh D.; Geraldes, Carlos F.G.C.. "Lanthanide DO3A-type complexes conjugated to Pittsburgh compound B as optical and MRI probes for targeting Aß amyloid aggregates involved in Alzheimer’s disease". Paper presented in 5th International Iberian Biophysics Congress, 2016.
Journal article
  1. "Modeling Gd3+ Complexes for Molecular Dynamics Simulations: Toward a Rational Optimization of MRI Contrast Agents". Inorganic Chemistry (2022): http://dx.doi.org/10.1021/acs.inorgchem.2c01597.
    10.1021/acs.inorgchem.2c01597
  2. Magalhães, Nisa; Simões, Guilherme M.; Ramos, Cristiana; Samelo, Jaime; Oliveira, Alexandre C.; Filipe, Hugo A. L.; Ramalho, João P. Prates; Moreno, Maria João; Loura, Luís M. S.. "Interactions between Rhodamine Dyes and Model Membrane Systems-Insights from Molecular Dynamics Simulations". Molecules 27 4 (2022): 1420. http://dx.doi.org/10.3390/molecules27041420.
    10.3390/molecules27041420
  3. "Concentration-Dependent Interactions of Amphiphilic PiB Derivative Metal Complexes with Amyloid Peptides Aß and Amylin**". Chemistry – A European Journal 27 6 (2021): 1864-1864. http://dx.doi.org/10.1002/chem.202004825.
    10.1002/chem.202004825
  4. Oliveira, Alexandre C.. "Concentration-dependent interactions of amphiphilic PiB- derivative metal complexes with amyloid peptides Aß and amylin". Chemistry – A European Journal (2020): http://dx.doi.org/10.1002/chem.202004000.
    10.1002/chem.202004000
  5. Oliveira, Alexandre C.. "Photophysical studies on lanthanide(III) chelates conjugated to Pittsburgh compound B as luminescent probes targeted to Aß amyloid aggregates". Photochemical & Photobiological Sciences (2020): http://dx.doi.org/10.1039/d0pp00214c.
    10.1039/d0pp00214c
  6. Martins, André F.; Oliveira, Alexandre C.; Morfin, Jean-François; Laurents, Douglas V.; Tóth, Éva; Geraldes, Carlos F. G. C.. "Associating a negatively charged GdDOTA-derivative to the Pittsburgh compound B for targeting Aß amyloid aggregates". JBIC Journal of Biological Inorganic Chemistry 21 1 (2015): 83-99. http://dx.doi.org/10.1007/s00775-015-1316-9.
    10.1007/s00775-015-1316-9
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/06/15 Modelling Gd-DOTA for molecular dynamics simulations in water and in presence of lipid bilayers 7th International Iberian Biophysics Congress
(Coimbra, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2018/05/30 - 2018/05/30 mini-Symposium -The life of Inorganic Chemistry: from molecules to imaging. (2018/05/30 - 2018/05/30)
Symposium (Member of the Organising Committee)
 Department of Chemistry at University of Coimbra, Portugal
2013/03/22 - 2013/03/24 1st National Meeting of Chemistry Students (2013/03/22 - 2013/03/24)
Meeting (Member of the Organising Committee)
 Chemistry Students of the Faculty of Science and Technology, University of Coimbra, Portugal

Association member

Society Organization name Role
2012 - 2013 Chemistry Student’s Association of the Chemistry Department at the University of Coimbra (NEQ/AAC) Vice-Chairman of the Plenary
2011 - 2013 Academic Association of Coimbra at the University of Coimbra (AAC) Member of professional goals division
Distinctions

Other distinction

2020 Fulbright Scholarship
Fulbright Portugal, Portugal
2020 Article selected for front page of Scientific Journal: DOI: 10.1002/chem.202004000
2020 Article selected for front page of Scientific Journal: DOI: 10.1039/D0PP00214C
2016 PhD fellowship
Fundação para a Ciência e a Tecnologia, Portugal