Steve Mendes Catarino (4E19-9B38-5F0B)

Curriculum Vitae

Steve Mendes Catarino

Steve Catarino (SC) obtained his degree in Biochemistry from the Faculty of Sciences and Technology, University of Coimbra (UC) in 2003 after conducting his final project work at the Biology of Ageing group (now known as Group of Ubiquitin-dependent proteolysis and Intercellular Communication, GuIC); in the Institute of Biomedical Imaging and Life Sciences (IBILI, now known as the Coimbra Institute for Clinical and Biomedical Research, iCBR), Faculty of Medicine, UC (FMUC). From 2003 to 2004 he worked as a Scientific Research Technician in the Biology of Ageing group of IBILI, FMUC, as part of a project studying the influence of hyperglycaemia upon intercellular communication. In 2004 he was awarded a PhD grant from the Fundação para a Ciência e Technologia (FCT) to carry out his thesis work at IBILI, FMUC; and at Harvard Medical School, Boston, MA, USA, which included experiments using small rodent animal models. SC obtained his PhD in Biomedical Sciences in 2010 with his work characterizing the intracellular trafficking of connexin proteins. From 2010 to 2011 SC continued his work at the Biology of Ageing group as a Scientific Research Technician, as part of a project studying gap junction remodelling in the ischemic heart. In 2011 SC was awarded an FCT post-doctoral grant carried out at IBILI, FMUC until 2017, in which he studied the ESCRT-dependent intracellular trafficking of Cx43. In 2017, SC obtained a post-doctoral grant through the HEALTHYAGING 2020 project (CENTRO-01-0145-FEDER-000012), to work in the GuIC group, at iCBR, FMUC, in a project aiming to characterize the communication between endothelial cells and cardiomyocytes during heart failure, which included two short-term scientific missions to Max Perutz Labs at the University of Vienna. From December 2018 to December 2024, within the frame of the transitional standard of the DL57-2016 law, SC worked as an Initial Level PhD Researcher at iCBR, FMUC, developing his work in the gap junction and cardiovascular sciences fields. Since May 2025, SC has been employed at iCBR/FMUC as an Invited Auxiliary Researcher.

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Identification

Personal identification

Full name: Steve Mendes Catarino

Citation names

Catarino, Steve

Author identifiers

Ciência ID: 4E19-9B38-5F0B
ORCID iD: 0000-0001-9644-6960

Telephones

Telephone

239480225 (Professional)

Addresses

Azinhaga de Santa Comba, iCBR, Pólo III Universidade de Coimbra, 3000-548, Coimbra, Coimbra, Portugal (Professional)

Knowledge fields

Natural sciences - Biological Sciences - Cell Biology
Natural sciences - Biological Sciences - Molecular Biology
Medical and Health Sciences - Clinical Medicine - Cardiac and Cardiovascular Systems

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
English (Mother tongue)
Portuguese (Mother tongue)

Education

	Degree	Classification
2010/10/22 Concluded	Ciências Biomédicas (Doutoramento) Major in Sem especialidade Universidade de Coimbra Faculdade de Medicina, Portugal "Mind the Gap. a New Molecular Model for the Intercellular Trafficking of Connexin43" (THESIS/DISSERTATION)
1998 - 2003 Concluded	Bioquímica (Licenciatura) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal	15

Affiliation

Science

	Category Host institution	Employer
2026/01/01 - Current	Invited Auxiliary Researcher (Research)	Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
	Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2025/05/26 - 2025/12/31	Invited Auxiliary Researcher (Research)	Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
	Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2018/12/26 - 2024/12/25	Contracted Researcher (Research)	Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
	Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
2011 - 2018/12/25	Postdoc (Research)	Universidade de Coimbra Faculdade de Medicina, Portugal
	Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
2010 - 2011	Research Trainee (Research)	Universidade de Coimbra Faculdade de Medicina, Portugal
	Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
2004 - 2009	Research Trainee (Research)	Universidade de Coimbra Faculdade de Medicina, Portugal
	Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
2003 - 2004	Research Trainee (Research)	Universidade de Coimbra Faculdade de Medicina, Portugal
	Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal

Projects

Grant

	Designation	Funders
2021/01 - 2025/12	Centro de Inovação em Biomedicina e Biotecnologia - Laboratório Associado 168189UID	Fundação para a Ciência e a Tecnologia
2018/06 - 2022/06	Um novo mecanismo para a reparação da Insuficiência Cardíaca com Fração de Ejeção Preservada e disfunção endotelial 153414PRJ	Fundação para a Ciência e a Tecnologia
2019/01 - 2019/12	CNC. IBILI 154730UID UID/NEU/04539/2019 Universidade de Coimbra, Portugal Universidade Nova de Lisboa ¿Laboratório de Instrumentação Engenharia Biomédica e Física da Radiação, Portugal Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2017/10 - 2017/10	A LIR-motif mediated interaction between the gap junction protein Connexin43 and LC3 Action BM1307 - 39607	European Cooperation in Science and Technology
2011/07/01 - 2017/06/30	ESCRTING GAP JUNCTION EXTERNALIZTION: A NEW MOLECULAR MECHANISM FOR REGULATION OF GAP JUNCTION INTERCELLULAR COMMUNICATION SFRH/BPD/68749/2010 31855DFA	Fundação para a Ciência e a Tecnologia Concluded
2012/04 - 2015/09	Um modelo animal para o estudo de alterações de proteostase associadas ao envelhecimento 118694PRJ	Fundação para a Ciência e a Tecnologia
2012/04 - 2015/06	Mecanismo moleculares envolvidos na redistribuição das gap junction no coração em isquémia 119296PRJ	Fundação para a Ciência e a Tecnologia
2011/01 - 2012/12	Projecto Estratégico - UI 3282 - 2011-2012 123346UID	Fundação para a Ciência e a Tecnologia
2008/11 - 2012/03	Um novo mecanismo para a disfunção endotelial na diabetes: Dos fenotipos às moleculas 67498PRJ	Fundação para a Ciência e a Tecnologia
2005/02/01 - 2009/01/31	REGULAÇÃO DA COMUNICAÇÃO INTERCELULAR EM CÉLULAS ENDOTELIAIS EM CONDIÇÕES DE HIPERGLICÉMIA - IMPLICAÇÕES NA RETINOPATIA DIABÉTICA SFRH/BD/20139/2004 17126DFA Harvard Medical School, United States	Fundação para a Ciência e a Tecnologia Concluded
2005/10 - 2007/12	Regulação da comunicação intercelular em condições de hiperglicémia - implicações na retinopatia diabética 57216PRJ	Fundação para a Ciência e a Tecnologia
2005/09 - 2007/12	Implicação da degradação do HIF na proliferação endotelial associada à retinopatia diabética 57772PRJ	Fundação para a Ciência e a Tecnologia

Contract

	Designation	Funders
2002/03/09 - Current	Degradation of GLUT1 by ubiquitin proteasome pathway as a novel regulatory mechanism for glucose transport on diabetic retinopathy info:eu-repo/grantAgreement/FCT/POCI/39142/PT Scientific Initiation Fellow	Universidade do Algarve Faculdade de Ciências e Tecnologia Concluded
2021/01/01 - 2025/12/31	Center for Innovative Biomedicine and Biotechnology - Associate Laboratory LA/P/0058/2020 10.54499/LA/P/0058/2020 Universidade de Coimbra, Portugal Universidade Nova de Lisboa ¿Laboratório de Instrumentação Engenharia Biomédica e Física da Radiação, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/12/26 - 2024/12/25	Not Available DL 57/2016/CP1370/CT0084 Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/06/22 - 2022/06/21	A novel mechanism to Re-Pair Heart Failure with Preserved Ejection Fraction (HFpEF) and endothelial damage PTDC/MED-PAT/32179/2017 Researcher Universidade de Coimbra Centro de Oftalmologia e Ciências da Visão, Portugal Universidade de Coimbra Faculdade de Medicina, Portugal Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2012/04/01 - 2015/09/30	An animal model for age-related changes in proteostasis info:eu-repo/grantAgreement/FCT/COMPETE/118694/PT PTDC/SAU-ORG/118694/2010 Researcher Universidade de Coimbra, Portugal Universidade de Coimbra Faculdade de Medicina, Portugal	Universidade do Algarve Faculdade de Ciências e Tecnologia Fundação para a Ciência e a Tecnologia Concluded
2012/04/01 - 2015/06/30	Unravelling the molecular events of gap junction remodelling in ischemic heart PTDC/SAU-ORG/119296/2010 info:eu-repo/grantAgreement/FCT/COMPETE/119296/PT Researcher Universidade de Coimbra, Portugal Universidade de Coimbra Faculdade de Medicina, Portugal	Fundação para a Ciência e a Tecnologia Universidade do Algarve Faculdade de Ciências e Tecnologia Concluded
2011/01/01 - 2012/12/31	Strategic Project - UI 3282 - 2011-2012 PEst-C/SAU/UI3282/2011 Universidade de Coimbra, Portugal Universidade de Coimbra Faculdade de Medicina, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2008/11/15 - 2012/03/13	A new route for endothelial dysfunction on diabetes: From phenotypes to molecules info:eu-repo/grantAgreement/FCT/5876-PPCDTI/67498/PT PTDC/SAU-OSM/67498/2006 Researcher Universidade de Coimbra, Portugal Universidade de Coimbra Faculdade de Medicina, Portugal	Universidade do Algarve Faculdade de Ciências e Tecnologia Fundação para a Ciência e a Tecnologia Concluded
2007/01/01 - 2007/12/31	What HIF? Degradation is better than growth in preventing angiogenesis in diabetic retinopathy info:eu-repo/grantAgreement/FCT/3599-PPCDT/82730/PT POCI/SAU-OBS/57772/2004 Researcher Universidade de Coimbra Faculdade de Medicina, Portugal	Universidade do Algarve Faculdade de Ciências e Tecnologia Fundação para a Ciência e a Tecnologia Concluded
2005/10/01 - 2007/12/31	Filling in the GAP: the missing link between intercellular communication and diabetic retinopathy. POCI/SAU-MMO/57216/2004 info:eu-repo/grantAgreement/FCT/POCI/57216/PT Researcher Universidade de Coimbra Faculdade de Medicina, Portugal	Fundação para a Ciência e a Tecnologia Universidade do Algarve Faculdade de Ciências e Tecnologia Concluded

Outputs

Publications

Conference abstract	Santos, Diogo; Alves, Raquel; Gonçalves, Ana Cristina; Jorge, Joana; Girão, Henrique; Catarino, Steve; Barbosa de Melo, Joana; Sarmento-Ribeiro, Ana B.. "Heat shock protein 90 inhibition as a potential therapeutic target in chronic myeloid leukemia". Paper presented in European Hematology Association, 2018. Published Santos, Diogo; Alves, Raquel; Gonçalves, Ana Cristina; Jorge, Joana; Catarino, Steve; Girão, Henrique; Barbosa de Melo, Joana; Sarmento-Ribeiro, Ana B.. "The potential therapeutic effect of Heat Shock Protein 90 inhibition in Chronic Myeloid Leukemia". Paper presented in CIMAGO Annual Scientific Meeting 2018, 2018. Published
Conference poster	Ribeiro-Rodrigues, Teresa M; Martins-Marques, Tânia; Catarino, Steve; Girao, Henrique. "A new regulatory mechanism of Cx43 degradation in the heart: chaperones enter the stage". Paper presented in SINAL 2019, X Meeting on Signal Transduction, Olhão, Portugal, 2019. Ribeiro-Rodrigues, Teresa M; Catarino, Steve; Batista-Almeida, Daniela; Abert, Christine; Martens, Sascha; Girao, Henrique. "Direct interaction with LC3 modulates Cx43 degradation in endothelial cells". Paper presented in IGJC 2019, Victoria, British Columbia, Canada, 2019. Domingues, Neuza; Cristóvão, Beatriz; Zuzarte, Mónica; Ribeiro-Rodrigues, Teresa M; Catarino, Steve; Girao, Henrique. "Unveiling the role of Cx43 in damaged lysosome secretion". Paper presented in EMBO Workshop 2019 - Proteostasis: From organelles to organisms, 2019. Santos, Diogo; Alves, Raquel; Gonçalves, Ana Cristina; Jorge, Joana; Girão, Henrique; Catarino, Steve; Barbosa de Melo, Joana; Sarmento-Ribeiro, Ana B.. "Alvespimycin is a promising drug in resistant Chronic Myeloid Leukemia". Paper presented in 13º YES Meeting, 2018. Ribeiro-Rodrigues, Teresa M; Catarino, Steve; Urbé, Sylvie; Clague, Michael; Girao, Henrique. "USP8 Regulates Cx43-mediated Intercellular Communication". Paper presented in Proteostatic Mechanisms in Health and Disease, Athens, Greece, 2018. 10.1158/1538-7445.am2011-1538 Catarino, Steve. "Interaction between Cx43 and LC3: an ubiquitin-independent pathway for degradation of Cx43 by autophagy". Paper presented in SINAL 2017 - 8th Meeting on Signal Transduction, 2017. Catarino, Steve. "USP8-mediated deubiquitination regulates the life-cycle of Cx43". Paper presented in SINAL 2017 - 8th Meeting on Signal Transduction, 2017. Catarino, Steve. "miR-424 and Smurf1: its significance in Pulmonary Arterial Hypertension". Paper presented in SINAL 2017 - 8th Meeting on Signal Transduction, 2017. Catarino, Steve. "A new regulatory mechanism of Cx43 degradation in the heart: CMA enters the stage". Paper presented in SINAL 2017 - 8th Meeting on Signal Transduction, 2017. Catarino, Steve. "Ubiquitination mediates the selective sorting of Cx43 into EVs". Paper presented in SINAL 2017 - 8th Meeting on Signal Transduction, 2017. Catarino, Steve. "EHD regulates the internalizationof Cx43 – a new player of ischemia-induced remodeling of gap junctions in the heart?". Paper presented in SINAL 2017 - 8th Meeting on Signal Transduction, 2017. Catarino, Steve. "EHD1 modulates intercellular trafficking of the gap junction protein Connexin43 (Cx43)". Paper presented in 1st Meeting on Vesicular Biology, 2017. Catarino, Steve. "A new regulatory mechanism of Cx43 degradation in the heart: CMA enters the stage.". Paper presented in 3rd PROTEOSTASIS Action Meeting, 2016. Catarino, Steve. "EHD regulates the internalization of Cx43 – a new player of ischemia-induced remodelling of gap junctions in the heart.". Paper presented in 3rd PROTEOSTASIS Action Meeting, 2016. Catarino, Steve. "USP8-mediated deubiquitination regulates the life-cycle of Cx43.". Paper presented in 7th Proteasome and Autophagy workshop, 2016. Catarino, Steve. "Interaction between Cx43 and LC3: an ubiquitin-independent pathway for degradation of Cx43 by autophagy.". Paper presented in VII Annual Meeting of IBILI, 2015. Catarino, Steve. "Usp8-mediated deubiquitination regulates the life-cycle of Cx43.". Paper presented in VII Annual Meeting of IBILI, 2015. Catarino, Steve. "MYO7A gene mutation effect in protein-protein interaction.". Paper presented in VII Annual Meeting of IBILI, 2015.
Journal article	Santos, Jailson de A.; Catarino, Steve; Mendes, Maria; Murtinho, Dina; Vitorino, Carla; Silva-Filho, Edson C.; Girao, Henrique; Valente, Artur J. M.; Muniz, Edvani C.. "Engineered poly(vinyl alcohol)-DNA hydrogels for sustained and biocompatible gene delivery". Journal of Drug Delivery Science and Technology (2025): https://publons.com/wos-op/publon/78782353/. 10.1016/J.JDDST.2025.107611 Mariana Magalhães; Eva María Domínguez-Martín; Joana Jorge; Ana Cristina Gonçalves; Francesca Massenzio; Renato Spigarelli; Teresa Ribeiro-Rodrigues; et al. "Unveiling the antitumor mechanism of 7a-acetoxy-6ß-hydroxyroyleanone from Plectranthus hadiensis in glioblastoma". Journal of Ethnopharmacology (2024): https://doi.org/10.1016/j.jep.2024.118689. 10.1016/j.jep.2024.118689 Neuza Domingues; Steve Catarino; Beatriz Cristóvão; Lisa Rodrigues; Filomena A Carvalho; Maria João Sarmento; Mónica Zuzarte; et al. "Connexin43 promotes exocytosis of damaged lysosomes through actin remodelling". The EMBO Journal (2024): https://doi.org/10.1038/s44318-024-00177-3. 10.1038/s44318-024-00177-3 Tania Martins-Marques; Katja Witschas; Ilda Ribeiro; Mónica Zuzarte; Steve Catarino; Teresa Ribeiro-Rodrigues; Francisco Caramelo; et al. "Cx43 can form functional channels at the nuclear envelope and modulate gene expression in cardiac cells". Open Biology (2023): http://dx.doi.org/10.1098/rsob.230258. 10.1098/rsob.230258 Beatriz Cristovao; Lisa Rodrigues; Steve Catarino; Monica Abreu; Teresa Gonçalves; Neuza Domingues; Girao H. "Cx43-mediated hyphal folding counteracts phagosome integrity loss during fungal infection". Microbiology Spectrum (2023): http://dx.doi.org/10.1128/spectrum.01238-23. 10.1128/spectrum.01238-23 Raquel Alves; Diogo Santos; Joana Jorge; Ana Cristina Gonçalves; Steve Catarino; Henrique Girão; Joana Barbosa Melo; Ana Bela Sarmento-Ribeiro. "Alvespimycin Inhibits Heat Shock Protein 90 and Overcomes Imatinib Resistance in Chronic Myeloid Leukemia Cell Lines". Molecules (2023): https://doi.org/10.3390/molecules28031210. 10.3390/molecules28031210 Girao, H.; Martins-Marques, T.; Catarino, S.; Ribeiro, I.; Marques Carreira, I.; Ribeiro-Rodrigues, T.; Witschas, K.; et al. "Gap junction protein connexin43 forms channels at the nuclear envelope of cardiac cells and modulates transcriptome profile". European Journal of Heart Failure (2023): https://publons.com/wos-op/publon/63083447/. Tania Martins-Marques; Marina C Costa; Steve Catarino; Isaura Simoes; Trond Aasen; Francisco J Enguita; Henrique Girao. "Cx43-mediated sorting of miRNAs into extracellular vesicles". EMBO reports (2022): https://doi.org/10.15252/embr.202154312. 10.15252/embr.202154312 Catarino, Steve. "Genetic determinants of arterial hypertension: A case of oxytocin receptor gene polymorphism". Revista Portuguesa de Cardiologia (2022): https://publons.com/wos-op/publon/59199781/. 10.1016/J.REPC.2022.07.009 Aires ID; Ribeiro-Rodrigues T; Boia R; Catarino S; Girão H; Ambrósio AF; Santiago AR. "Exosomes derived from microglia exposed to elevated pressure amplify the neuroinflammatory response in retinal cells.". Glia (2020): http://europepmc.org/abstract/med/32645245. 10.1002/glia.23880 S Catarino; Teresa M Ribeiro-Rodrigues; Rita Sá Ferreira; José Ramalho; Christine Abert; Sascha Martens; Girao H. "A Conserved LIR Motif in Connexins Mediates Ubiquitin-Independent Binding to LC3/GABARAP Proteins". Cells (2020): https://www.mdpi.com/2073-4409/9/4/902. 10.3390/cells9040902 Martins-Marques T; Catarino S; Gonçalves A; Miranda-Silva D; Gonçalves LM; Antunes PE; Coutinho G; et al. "EHD1 Modulates Cx43 Gap Junction Remodeling Associated with Cardiac Diseases.". Circulation research (2020): http://europepmc.org/abstract/med/32138615. 10.1161/circresaha.119.316502 Santiago, Ana Raquel; Aires, Ines Dinis; Ribeiro-Rodrigues, Teresa; Boia, Raquel; Catarino, Steve; Almeida, Daniela; Girao, Henrique; Ambrosio, Antonio F.. "Extracellular vesicles released by microglia exposed to elevated hydrostatic pressure promote retinal neural cell loss and microglia reactivity". Investigative Ophthalmology & Visual Science (2019): https://publons.com/wos-op/publon/28332477/. Marques, Tania Martins; Catarino, Steve; Almeida, Claudia G.; Girao, Henrique. "EHD proteins mediate ubiquitin-dependent recycling of gap junctions (GJs) in the ischemic heart". European Journal of Clinical Investigation (2019): https://publons.com/wos-op/publon/28332473/. Aires, I. D.; Ribeiro-Rodrigues, T.; Boia, R.; Catarino, S.; Almeida, D.; Girao, H.; Ambrosio, A. F.; Santiago, A. R.. "Exosomes derived from microglia exposed to elevated pressure code for an inflammatory response: implications for retinal degeneration". Glia (2019): https://publons.com/wos-op/publon/32385847/. Martins-Marques, T.; Catarino, S.; Almeida, C. G.; Girao, H.. "EHD proteins mediate gap junction (GJ) remodeling during myocardial ischemia". European Heart Journal (2018): https://publons.com/wos-op/publon/28332479/. Catarino, Steve; Pereira, Paulo; Girão, Henrique; Catarino, S.; Pereira, P.; Girao, H.. "Molecular control of chaperone-mediated autophagy". Essays in Biochemistry 61 6 (2017): 663-674. http://dx.doi.org/10.1042/ebc20170057. 10.1042/ebc20170057 Baptista, Rui; Marques, Carla; Catarino, Steve; Enguita, Francisco J; Costa, Marina C; Matafome, Paulo; Zuzarte, Mónica; et al. "MicroRNA-424(322) as a new marker of disease progression in pulmonary arterial hypertension and its role in right ventricular hypertrophy by targeting SMURF1". Cardiovascular Research 114 1 (2017): 53-64. http://dx.doi.org/10.1093/cvr/cvx187. 10.1093/cvr/cvx187 Ribeiro-Rodrigues TM; Catarino S; Pinho MJ; Pereira P; Girao H. "Connexin 43 ubiquitination determines the fate of gap junctions: restrict to survive.". (2015): http://europepmc.org/abstract/med/26009193. 10.1042/BST20150036 Martins-Marques T; Catarino S; Marques C; Pereira P; Girão H. "To beat or not to beat: degradation of Cx43 imposes the heart rhythm.". (2015): http://europepmc.org/abstract/med/26009194. 10.1042/BST20150046 Martins-Marques, Tânia; Catarino, Steve; Marques, Carla; Matafome, Paulo; Ribeiro-Rodrigues, Teresa; Baptista, Rui; Pereira, Paulo; Girão, Henrique. "Heart ischemia results in connexin43 ubiquitination localized at the intercalated discs". Biochimie 112 (2015): 196-201. http://dx.doi.org/10.1016/j.biochi.2015.02.020. 10.1016/j.biochi.2015.02.020 Martins-Marques T; Catarino S; Zuzarte M; Marques C; Matafome P; Pereira P; Girão H. "Ischaemia-induced autophagy leads to degradation of gap junction protein connexin43 in cardiomyocytes.". (2015): http://europepmc.org/abstract/med/25605500. 10.1042/BJ20141370 Catarino, Steve. "Corrigendum: Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells.". Scientific Reports (2015): http://europepmc.org/abstract/med/26445927. 10.1038/srep14888 Soares AR; Martins-Marques T; Ribeiro-Rodrigues T; Ferreira JV; Catarino S; Pinho MJ; Zuzarte M; et al. "Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells.". (2015): http://europepmc.org/abstract/med/26285688. 10.1038/srep13243 Ribeiro-Rodrigues, Teresa M.; Catarino, Steve; Marques, Carla; Ferreira, João V.; Martins-Marques, Tânia; Pereira, Paulo; Girão, Henrique. "AMSH-mediated deubiquitination of Cx43 regulates internalization and degradation of gap junctions". The FASEB Journal 28 11 (2014): 4629-4641. http://dx.doi.org/10.1096/fj.13-248963. 10.1096/fj.13-248963 Catarino, Steve; Bento, Carla F.; Brito, Ana; Murteira, Eliana; Fernandes, Alexandre F.; Pereira, Paulo. "Regulation of the expression of interleukin-8 induced by 25-hydroxycholesterol in retinal pigment epithelium cells". Acta Ophthalmologica 90 4 (2012): e255-e263. http://dx.doi.org/10.1111/j.1755-3768.2011.02350.x. 10.1111/j.1755-3768.2011.02350.x Catarino, S.; Ramalho, J.S.; Marques, C.; Pereira, P.; Girão, H.. "Ubiquitin-mediated internalization of connexin43 is independent of the canonical endocytic tyrosine-sorting signal". Biochemical Journal 437 2 (2011): 255-267. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959687376&partnerID=MN8TOARS. 10.1042/BJ20102059 Girão, Henrique; Catarino, Steve; Pereira, Paulo. "Eps15 interacts with ubiquitinated Cx43 and mediates its internalization". Experimental Cell Research 315 20 (2009): 3587-3597. http://dx.doi.org/10.1016/j.yexcr.2009.10.003. 10.1016/j.yexcr.2009.10.003 Girão, Henrique; Catarino, Steve; Pereira, Paulo; Girão, H.; Catarino, S.; Pereira, P.. "7-Ketocholesterol modulates intercellular communication through gap-junction in bovine lens epithelial cells.". Cell Communication and Signaling 2 1 (2004): 2. http://dx.doi.org/10.1186/1478-811x-2-2. 10.1186/1478-811x-2-2
Preprint	Mariana Magalhães; Eva María Domínguez-Martín; Joana Jorge; Ana Cristina Gonçalves; Francesca Massenzio; Renato Spigarelli; Teresa Ribeiro-Rodrigues; et al. "Unveiling the Antitumor Mechanism of 7a-Acetoxy-6ß-Hydroxyroyleanone from Plectranthus hadiensis in Glioblastoma". 2024. https://doi.org/10.20944/preprints202405.0775.v1. 10.20944/preprints202405.0775.v1 Neuza Domingues; Steve Catarino; Beatriz Cristovao; Lisa Rodrigues; Carvalho Filomena; Maria Joao Sarmento; Monica Zuzarte; et al. "Cx43 promotes exocytosis of damaged lysosomes through actin remodelling". 2022. https://doi.org/10.21203/rs.3.rs-2277227/v1. 10.21203/rs.3.rs-2277227/v1
Thesis / Dissertation	Catarino, Steve Mendes. "Mind the gap : a new molecular model for the intracellular trafficking of connexin 43". PhD, 2010. http://hdl.handle.net/10316/14239.

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2024/01/30	Connexins, exocytosis and extracellular vesicles	IV Metabolism, Ageing and Disease (MAD) Meeting CIBB (Coimbra, Portugal)
2018/02/17	Cx43 interacts directly with LC3 protein family members through a LIR motif	1st Meeting on Vesicular Biology (Coimbra, Portugal)
2016/11/02	Interaction between Cx43 and LC3: an ubiquitin-independent pathway for degradation of Cx43 by autophagy	3rd PROTEOSTASIS Action Meeting (Lisbon, Portugal)
2010/12/10	Regulation of intercellular communication by ubiquitin	2nd Annual Meeting of IBILI (Coimbra, Portugal)
2004/11/17	Degradação dependente do proteossoma da Cx43 em células epiteliais do cristalino requer o terminal carboxílico da proteína	IV Congresso de Investigação em Medicina (Coimbra, Portugal)
2004/09/24	Proteasome-dependent degradation of Cx43 in lens epithelial cells requires the carboxyl-terminal of the protein.	EVER-European Association for Vision and Eye Research 2004 (Vilamoura, Portugal)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2023/09/01 - 2024/09/05	The influence of lysosomal injury in transthyretin amyloid cardiomyopathy Co-supervisor	Mestrado em Investigação Biomédica (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2015/04/01 - 2016/04/01	Molecular studies of a novel mutation in MYO7A gene in Usher Syndrome type I Co-supervisor	Mestrado Integrado em Medicina (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2015 - 2015	Interaction between Cx43 and LC3 directs gap junctions to ubiquitin-independent autophagy degradation Co-supervisor	Investigação Biomédica (Master) Universidade de Coimbra Faculdade de Medicina, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2025	The role of CLN3 in lysosome distribution and nuclear homeostasis in Batten disease (Thesis) Arguer	Sofia Freire Roque (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2023	Using a high-throughput genetic screen to identify plasmodium molecules that interact with the host’s innate immune system (Thesis) Arguer	Rita Mateus Lopes (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2023	Oncodynamics – an integrated analysis of the host response to cancer (Thesis) Arguer	João Pedro Coelho Monteiro (Master) Universidade de Coimbra Faculdade de Medicina, Portugal
2013	DUBs modulate the ubiquitin signal that targets Cx43 for autophagy Thesis Member	Ana Sofia Filipe Pinheiro (Master) Universidade de Coimbra Faculdade de Medicina, Portugal