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Nuno Borges is Auxiliary Researcher at the Marine and Environmental Sciences Centre - Polytechnic Institute of Setúbal (MARE-IPS). He is Invited Adjunct Professor of Microbiology (Environmental and Food) and Food Safety in Aquaculture at the Setúbal School of Technology, Polytechnic Institute of Setúbal (EST-IPS), Portugal. He graduated in biochemistry at the Faculty of Sciences, University of Lisbon (Portugal) in 1999. He obtained his Ph.D. degree in biochemistry at the Instituto de Tecnologia Química e Biológica (ITQB), New University of Lisbon (Portugal) in 2004, and was a postdoctoral fellow at the ITQB (Portugal), Universidad Autónoma de Madrid (Spain), and Kyoto University (Japan) from 2004 to 2008. He was then awarded the Research Scientist contract "Ciência" (2008-2019) at the ITQB. From 2019 to 2021, he was a doctorate Researcher at the Institute for Bioengineering and Biosciences, Instituto Superior Técnico (Portugal). He has published 34 articles in peer-reviewed international journals, with an h-index of 21 and an i-10 index of 27. His published work has been cited more than 1,400 times, being welcomed by highly ranked, multidisciplinary, and specialized journals such as Annual Reviews in Animal Biosciences, Environmental Microbiology, Nature communications, Microbiological Research, and applied and Environmental Microbiology. Since 2007, he has contributed as reviewer for several indexed journals, including Extremophiles, J. Bacteriology, and Research in Microbiology. Since 2010, he has supervised 4 Ph.D., 2 M.Sc., and 4 undergraduate students (1 ongoing) in the framework of 16 R&D projects (2 as principal investigator). He was invited to deliver 5 oral communications in international conferences. He co-organized one international congress (400 participants) and was engaged as a co-organizer or participant in several dissemination activities. Dr. Borges's interest in the development of microbiome-derived applications to improve food production led him to perform advanced research on the beneficial symbionts of land plants and fish. In 2022, he started a novel aquaculture and molecular microbiology laboratory at EST-IPS. Currently, he is focused on the suppression of shellfish/fish diseases caused by opportunistic bacteria in aquaculture using microbiome therapy to sustainably manage human-made ecosystems.
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Identification

Personal identification

Full name
Nuno Miguel Formiga Borges

Citation names

  • Borges, Nuno

Author identifiers

Ciência ID
4D1C-299C-14B6
ORCID iD
0000-0002-3277-8517

Email addresses

  • nuno.borges@estsetubal.ips.pt (Professional)
  • nuno.borges@estsetubal.ips.pt (Personal)

Addresses

  • Instituto Politécnico de Setúbal, Escola Superior de Tecnologia de Setúbal, Departamento de Sistemas e Informática. Campus IPS, Estefanilha, 2914-508, Setúbal, Setúbal, Portugal (Professional)

Knowledge fields

  • Agrarian Sciences - Agriculture, Forestry and Fisheries

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2018/08/09
Concluded
 Contabilidade e Administração (Licenciatura)
Instituto Politécnico de Lisboa Instituto Superior de Contabilidade e Administração de Lisboa, Portugal
 16/20
2004
Concluded
 Biochemistry (Doutoramento)
Major in Especialidade: Bioquímica
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
"The Role of Mannosylglycerate in Thermo- and Osmo-adaptation of Rhodothermus Marinus: Biosynthesis, Regulation and Applications" (THESIS/DISSERTATION)
1998/10/19
Concluded
 Biochemistry (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
 16/20
Affiliation

Science

Category
Host institution 		Employer
2023 - Current Auxiliary Researcher (Research) MARE-IPS (Marine and Environmental Sciences Centre - Polytechnic Institute of Setúbal, Portugal), Portugal
2021/10/01 - 2022/06/30 Contracted Researcher (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2018/03/28 - 2021/09/30 Contracted Researcher (Research) Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
2008/03/01 - 2018/02/28 Auxiliary Researcher (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2004/08/01 - 2008/02/29 Postdoc (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2022/03/01 - Current Invited Adjunct Teacher (Polytechnic Teacher) Instituto Politécnico de Setúbal, Portugal
Instituto Politécnico de Setúbal Escola Superior de Tecnologia de Setúbal, Portugal
Projects

Grant

Designation Funders
2013/07 - 2016/06 NMR Net - National Facility for Nuclear Magnetic Resonance: from Molecular Structure and Dynamics to Protein Function, Cell Physiology, and Metabolomics
grant.Provided by PTCRIS: 127013
RECI/BBB-BQB/0230/2012
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal

Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Fundação para a Ciência e a Tecnologia

Stichting Weten
Concluded
2007/10/01 - 2008/02/29 UNDERSTANDING HOW THE HYPERTHERMOPHILIC ARCHAEA SENSE AND RESPOND TO STRESS
SFRH/BPD/36653/2007
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2004/08/01 - 2007/07/31 HEAT STRESS RESPONSE IN RHODOTHERMUS MARINUS: CHEMICAL AND MOLECULAR CHAPERONES IN THERMO AND OSMO- -ADAPTATION
SFRH/BPD/14841/2003
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
1999/10/01 - 2003/09/30 METABOLISMO DE CARBOHIDRATOS E RESPECTIVA ENZIMOLOGIA EM ARQUEBACTÉRIAS HIPERTERMÓFILAS
PRAXIS XXI/BD/19868/99
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2023/06/21 - 2029/06/20 Improving juvenile fish growth and survival by using live feed enriched with probiotics to promote sustainable aquaculture practices
CEECINST/00036/2021/CP2776/CT0004
10.54499/CEECINST/00036/2021/CP2776/CT0004
Instituto Politécnico de Setúbal, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2020/01/01 - 2024/12/31 Institute for Research and Innovation in Health
UIDB/04293/2020
10.54499/UIDB/04293/2020
LA/P/0070/2020
10.54499/LA/P/0070/2020
UIDP/04293/2020
10.54499/UIDP/04293/2020
UID/BIM/04293/2019
Instituto de Astrofísica e Ciências do Espaço, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022/01/01 - 2023/12/31 Harnessing the catalyst power of host-microbe interactions: a quest for novel chitinases from octocoral symbionts
EXPL/BIA-MIC/0286/2021
10.54499/EXPL/BIA-MIC/0286/2021
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013/05/01 - 2015/10/31 Structural investigation of the anti-tuberculosis drug target phosphatidylinositol phosphate synthase (PIPS)
PTDC/BBB-BEP/2532/2012
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2008/03/01 - 2013/02/28 Understanding how hyperthermophilic archaea sense and respond to heat stress
CONT_DOUT/35/ITQB/2621/6099/ 9/2006
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010 - 2013 PTDC/AGR-AAM/100577/2008 Biofertilizantes fixadores de azoto para culturas de gramíneas.
PTDC/AGR-AAM/100577/2008
PTDC/AGR-AAM/100577/2008
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

Instituto Nacional de Investigação Agrária e Veterinária, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008/05/05 - 2012/04/30 Estudo dos mecanismos de adaptação a stress térmico em microorganismos hipertermófilos: função fisiológica de poliolfosfodiésteres
PTDC/BIA-MIC/71146/2006
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2005/06/15 - 2007/10/14 Strategies of life adaptation to hot environments: Heat and osmotic stress responses in the extremely thermophilic bacterium Rhodothermus marinus
POCI/BIA-MIC/59310/2004
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Santos, H; Lamosa, P.; Borges, Nuno; Gonçalves, L.G.; Pais, T.M.; Rodrigues, M.V.. "Organic compatible solutes of prokaryotes that thrive in hot environments: the importance of ionic compounds for thermostabilization". In Extremophiles Handbook. 2011.
    Published • 10.1007/978-4-431-53898-1_23
  2. Santos, Helena; Lamosa, Pedro; Faria, Tiago Q.; Borges, Nuno; Neves, ClÉlia. "The Physiological Role, Biosynthesis, and Mode of Action of Compatible Solutes from (Hyper)Thermophiles". In Physiology and Biochemistry of Extremophiles, 86-103. American Society of Microbiology, 2007.
    10.1128/9781555815813.ch7
  3. Santos, H.; Lamosa, P.; Borges, N.. "Characterization and Quantification of Compatible Solutes in (Hyper)thermophilic Microorganisms". 2006.
    10.1016/S0580-9517(08)70011-4
Conference paper
  1. Galhanas, D.; Mata, Ana M. T.; Borges, Nuno; Simões, Manuela; Manuela Silvestre; Salgado, R.. "Effect of oyster pseudofaeces on water and oyster quality during the cultivation process". Beja, 2024.
    Accepted
Journal article
  1. Yaqi Liu; Chelsea M. Brown; Nuno Borges; Rodrigo N. Nobre; Satchal Erramilli; Meagan Belcher Dufrisne; Brian Kloss; et al. "Mechanistic studies of mycobacterial glycolipid biosynthesis by the mannosyltransferase PimE". Nature Communications (2025): https://doi.org/10.1038/s41467-025-57843-1.
    10.1038/s41467-025-57843-1
  2. Nobre, Rodrigo N.; Esteves, Ana M.; Borges, Nuno; Rebelo, Sara; Liu, Yaqi; Mancia, Filippo; Santos, Helena. "Production and Purification of Phosphatidylinositol Mannosides from Mycobacterium smegmatis Biomass". Current Protocols 2 6 (2022): http://dx.doi.org/10.1002/cpz1.458.
    10.1002/cpz1.458
  3. Borges, Nuno. "Bacteriome Structure, Function, and Probiotics in Fish Larviculture: The Good, the Bad, and the Gaps.". Annual review of animal biosciences (2020): https://doi.org/10.1146/annurev-animal-062920-113114.
    10.1146/annurev-animal-062920-113114
  4. Borges, Nuno. "Metagenome-Assembled Genome Sequences of Three Uncultured Planktomarina sp. Strains from the Northeast Atlantic Ocean.". Microbiology resource announcements (2020): https://europepmc.org/articles/PMC7082456.
    10.1128/mra.00127-20
  5. Borges, Nuno; Pastor, José M.; Borges, Nuno; Pagán, Juan P.; Castaño-Cerezo, Sara; Csonka, Laszlo N.; Goodner, Bradley W.; et al. "Fructose metabolism in Chromohalobacter salexigens: interplay between the Embden-Meyerhof-Parnas and Entner-Doudoroff pathways". Microbial Cell Factories 18 1 (2019): http://dx.doi.org/10.1186/s12934-019-1178-x.
    10.1186/s12934-019-1178-x
  6. Esteves, A.M.; Graça, G.; Peyriga, L.; Torcato, I.M.; Borges, N.; Portais, J.-C.; Santos, H.. "Combined transcriptomics–metabolomics profiling of the heat shock response in the hyperthermophilic archaeon Pyrococcus furiosus". Extremophiles 23 1 (2019): 101-118. http://www.scopus.com/inward/record.url?eid=2-s2.0-85056482652&partnerID=MN8TOARS.
    10.1007/s00792-018-1065-0
  7. Faria, C.; Borges, N.; Rocha, I.; Santos, H.. "Production of mannosylglycerate in Saccharomyces cerevisiae by metabolic engineering and bioprocess optimization". Microbial cell factories 17 1 (2018): 178-178. http://www.scopus.com/inward/record.url?eid=2-s2.0-85056705726&partnerID=MN8TOARS.
    10.1186/s12934-018-1023-7
  8. Castanheira, N.L.; Dourado, A.C.; Pais, I.; Semedo, J.; Scotti-Campos, P.; Borges, N.; Carvalho, G.; Barreto Crespo, M.T.; Fareleira, P.. "Colonization and beneficial effects on annual ryegrass by mixed inoculation with plant growth promoting bacteria". Microbiological Research 198 (2017): 47-55. http://www.scopus.com/inward/record.url?eid=2-s2.0-85013661457&partnerID=MN8TOARS.
    10.1016/j.micres.2017.01.009
  9. Rodrigues, M.V.; Borges, N.; Santos, H.. "Glycerol phosphate cytidylyltransferase stereospecificity is key to understanding the distinct stereochemical compositions of glycerophosphoinositol in Bacteria and Archaea". Applied and Environmental Microbiology 83 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85009964403&partnerID=MN8TOARS.
    10.1128/AEM.02462-16
  10. Castanheira, N.; Dourado, A.C.; Kruz, S.; Alves, P.I.L.; Delgado-Rodríguez, A.I.; Pais, I.; Semedo, J.; et al. "Plant growth-promoting Burkholderia species isolated from annual ryegrass in Portuguese soils". Journal of Applied Microbiology 120 3 (2016): 724-739. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959038102&partnerID=MN8TOARS.
    10.1111/jam.13025
  11. Jorge, C.D.; Borges, N.; Bagyan, I.; Bilstein, A.; Santos, H.. "Potential applications of stress solutes from extremophiles in protein folding diseases and healthcare". Extremophiles 20 3 (2016): 251-259. http://www.scopus.com/inward/record.url?eid=2-s2.0-84963670607&partnerID=MN8TOARS.
    10.1007/s00792-016-0828-8
  12. Jorge, C.D.; Borges, N.; Santos, H.. "A novel pathway for the synthesis of inositol phospholipids uses cytidine diphosphate (CDP)-inositol as donor of the polar head group". Environmental Microbiology 17 7 (2015): 2492-2504. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937073217&partnerID=MN8TOARS.
    10.1111/1462-2920.12734
  13. Nádia Castanheira; Ana Catarina Dourado; Paula Isabel Alves; Alícia Maria Cortés-Pallero; Ana Isabel Delgado-Rodríguez; Ângela Prazeres; Nuno Borges; et al. "Annual ryegrass-associated bacteria with potential for plant growth promotion". Microbiological Research 169 9-10 (2014): 768-779. http://dx.doi.org/10.1016/j.micres.2013.12.010.
    10.1016/j.micres.2013.12.010
  14. Borges, N.; Jorge, C.D.; Gonçalves, L.G.; Gonçalves, S.; Matias, P.M.; Santos, H.. "Mannosylglycerate: structural analysis of biosynthesis and evolutionary history". Extremophiles 18 5 (2014): 835-852. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929510245&partnerID=MN8TOARS.
    10.1007/s00792-014-0661-x
  15. Nogly, P.; Gushchin, I.; Remeeva, A.; Esteves, A.M.; Borges, N.; Ma, P.; Ishchenko, A.; et al. "X-ray structure of a CDP-alcohol phosphatidyltransferase membrane enzyme and insights into its catalytic mechanism". Nature Communications 5 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84903147718&partnerID=MN8TOARS.
    10.1038/ncomms5169
  16. Esteves, A.M.; Chandrayan, S.K.; McTernan, P.M.; Borges, N.; Adams, M.W.W.; Santos, H.. "Mannosylglycerate and di-myo-inositol phosphate have interchangeable roles during adaptation of Pyrococcus furiosus to heat stress". Applied and Environmental Microbiology 80 14 (2014): 4226-4233. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903182320&partnerID=MN8TOARS.
    10.1128/AEM.00559-14
  17. Quintas, P.O.; Cepeda, A.P.; Borges, N.; Catarino, T.; Turner, D.L.. "Relative importance of driving force and electrostatic interactions in the reduction of multihaem cytochromes by small molecules". Biochimica et Biophysica Acta - Bioenergetics 1827 6 (2013): 745-750. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875943702&partnerID=MN8TOARS.
    10.1016/j.bbabio.2013.02.006
  18. Faria, C.; Jorge, C.D.; Borges, N.; Tenreiro, S.; Outeiro, T.F.; Santos, H.. "Inhibition of formation of a-synuclein inclusions by mannosylglycerate in a yeast model of Parkinson's disease". Biochimica et Biophysica Acta - General Subjects 1830 8 (2013): 4065-4072. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877839143&partnerID=MN8TOARS.
    10.1016/j.bbagen.2013.04.015
  19. Gonçalves, L.G.; Borges, N.; Serra, F.; Fernandes, P.L.; Dopazo, H.; Santos, H.. "Evolution of the biosynthesis of di-myo-inositol phosphate, a marker of adaptation to hot marine environments". Environmental Microbiology 14 3 (2012): 691-701. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857855641&partnerID=MN8TOARS.
    10.1111/j.1462-2920.2011.02621.x
  20. Gonçalves, S.; Esteves, A.M.; Santos, H.; Borges, N.; Matias, P.M.. "Three-dimensional structure of mannosyl-3-phosphoglycerate phosphatase from thermus thermophilus HB27: A new member of the haloalcanoic acid dehalogenase superfamily". Biochemistry 50 44 (2011): 9551-9567. http://www.scopus.com/inward/record.url?eid=2-s2.0-80155206893&partnerID=MN8TOARS.
    10.1021/bi201171h
  21. Brito, J.A.; Borges, N.; Vonrhein, C.; Santos, H.; Archer, M.. "Crystal structure of archaeoglobus fulgidus CTP:Inositol-1-phosphate cytidylyltransferase, a key enzyme for di-myo-inositol-phosphate synthesis in (hyper)thermophiles". Journal of Bacteriology 193 9 (2011): 2177-2185. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955532914&partnerID=MN8TOARS.
    10.1128/JB.01543-10
  22. Gonçalves, S.; Esteves, A.M.; Borges, N.; Santos, H.; Matias, P.M.. "Crystallization and preliminary X-ray analysis of mannosyl-3- phosphoglycerate phosphatase from Thermus thermophilus HB27". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 67 3 (2011): 390-396. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952692197&partnerID=MN8TOARS.
    10.1107/S1744309111002843
  23. Borges, N.; Matsumi, R.; Imanaka, T.; Atomi, H.; Santos, H.. "Thermococcus kodakarensis mutants deficient in di-myo-inositol phosphate use aspartate to cope with heat stress". Journal of Bacteriology 192 1 (2010): 191-197. http://www.scopus.com/inward/record.url?eid=2-s2.0-73849124968&partnerID=MN8TOARS.
    10.1128/JB.01115-09
  24. Brito, J.A.; Borges, N.; Santos, H.; Archer, M.. "Production, crystallization and preliminary X-ray analysis of CTP:inositol-1-phosphate cytidylyltransferase from Archaeoglobus fulgidus". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 66 11 (2010): 1463-1465. http://www.scopus.com/inward/record.url?eid=2-s2.0-78149345319&partnerID=MN8TOARS.
    10.1107/S1744309110032677
  25. Gonçalves, S.; Borges, N.; Esteves, A.M.; Victor, B.L.; Soares, C.M.; Santos, H.; Matias, P.M.. "Structural analysis of Thermus thermophilus HB27 mannosyl-3- phosphoglycerate synthase provides evidence for a second catalytic metal ion and new insight into the retaining mechanism of glycosyltransferases". Journal of Biological Chemistry 285 23 (2010): 17857-17868. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952938697&partnerID=MN8TOARS.
    10.1074/jbc.M109.095976
  26. Gonçalves, S.; Borges, N.; Santos, H.; Matias, P.M.. "Crystallization and preliminary x-ray analysis of mannosyl-3- phosphoglycerate synthase from thermus thermophilus HB27". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 65 10 (2009): 1014-1017. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350312647&partnerID=MN8TOARS.
    10.1107/S1744309109032576
  27. Rodrigues, M.V.; Borges, N.; Almeida, C.P.; Lamosa, P.; Santos, H.. "A unique ß-1,2-mannosyltransferase of Thermotoga maritima that uses di-myo-inositol phosphate as the mannosyl acceptor". Journal of Bacteriology 191 19 (2009): 6105-6115. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349096860&partnerID=MN8TOARS.
    10.1128/JB.00598-09
  28. Rodrigues, M.V.; Borges, N.; Henriques, M.; Lamosa, P.; Ventura, R.; Fernandes, C.; Empadinhas, N.; et al. "Bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol: Inositol-1-phosphate transferase, the key enzyme for di-myo-inositol-phosphate synthesis in several (hyper)thermophiles". Journal of Bacteriology 189 15 (2007): 5405-5412. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547629796&partnerID=MN8TOARS.
    10.1128/JB.00465-07
  29. Cardoso, F.S.; Castro, R.F.; Borges, N.; Santos, H.. "Biochemical and genetic characterization of the pathways for trehalose metabolism in Propionibacterium freudenreichii, and their role in stress response". Microbiology 153 1 (2007): 270-280. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846305426&partnerID=MN8TOARS.
    10.1099/mic.0.29262-0
  30. Borges, N.; Gonçalves, L.G.; Rodrigues, M.V.; Siopa, F.; Ventura, R.; Maycock, C.; Lamosa, P.; Santos, H.. "Biosynthetic pathways of inositol and glycerol phosphodiesters used by the hyperthermophile Archaeoglobus fulgidus in stress adaptation". Journal of Bacteriology 188 23 (2006): 8128-8135. http://www.scopus.com/inward/record.url?eid=2-s2.0-33751559039&partnerID=MN8TOARS.
    10.1128/JB.01129-06
  31. Borges, N.; Marugg, J.D.; Empadinhas, N.; Da Costa, M.S.; Santos, H.. "Specialized Roles of the Two Pathways for the Synthesis of Mannosylglycerate in Osmoadaptation and Thermoadaptation of Rhodothermus marinus". Journal of Biological Chemistry 279 11 (2004): 9892-9898. http://www.scopus.com/inward/record.url?eid=2-s2.0-1642279326&partnerID=MN8TOARS.
    10.1074/jbc.M312186200
  32. Borges, N.; Ramos, A.; Raven, N.D.H.; Sharp, R.J.; Santos, H.. "Comparative study of the thermostabilizing properties of mannosylglycerate and other compatible solutes on model enzymes". Extremophiles 6 3 (2002): 209-216. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036599177&partnerID=MN8TOARS.
    10.1007/s007920100236
  33. Empadinhas, N.; Marugg, J.D.; Borges, N.; Santos, H.; Da Costa, M.S.. "Pathway for the synthesis of mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii: Biochemical and genetic characterization of key enzymes". Journal of Biological Chemistry 276 47 (2001): 43580-43588. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035941355&partnerID=MN8TOARS.
    10.1074/jbc.M108054200
  34. Cánovas, D.; Borges, N.; Vargas, C.; Ventosa, A.; Nieto, J.J.; Santos, H.. "Role of N-gama-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine". Applied and Environmental Microbiology 65 9 (1999): 3774-3779. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032586949&partnerID=MN8TOARS.
  35. Silva, Z.; Borges, N.; Martins, L.O.; Wait, R.; Da Costa, M.S.; Santos, H.. "Combined effect of the growth temperature and salinity of the medium on the accumulation of compatible solutes by Rhodothermus marinus and Rhodothermus obamensis". Extremophiles 3 2 (1999): 163-172. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033136552&partnerID=MN8TOARS.
    10.1007/s007920050112
Preprint
  1. Liu, Yaqi; Brown, Chelsea M.; Borges, Nuno; Nobre, Rodrigo N.; Erramilli, Satchal; Dufrisne, Meagan Belcher; Kloss, Brian; et al. "Mechanistic studies of mycobacterial glycolipid biosynthesis by the mannosyltransferase PimE". 2024. https://doi.org/10.1101/2024.09.17.613550.
    10.1101/2024.09.17.613550
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/02/04 Oral Poster Presentation: Identification and characterization of bacteria with hydrolytic and antibacterial activities isolated from gilthead sea bream (Sparus aurata) for application as probiotics in larviculture. 1st Microbiome PT Summit
BioData.pt and ELIXIR-PT, Online event (Lisbon, Portugal)
2012/09/11 Biosynthesis, evolution and role of unique compatible solutes in heat stress adaptation of marine hyperthermophiles The 9th International Conference on Extremophiles, September, 10-13, 2012, Sevilla, Spain
(Sevilla, Spain)
2011/09/11 Role, evolution, and regulation of the synthesis of di-myo-inositol-phosphate in hyperthermophiles The 11th International Conference on Thermophiles Research, September, 11-16, 2011, Big Sky, Montana, EUA.
(Montana, United States)
2008/09/10 Kinetic and structural characterization of the enzymes involved in the synthesis of di-myo-inositol-phosphate in Archaeoglobus fulgidus. The 7th International Conference on Extremophiles, 7-11, September, 2008, Cape Town, South africa
(Cape Town, South Africa)
2005/12/01 The role of compatible solutes in osmoadaptation and thermoadaptation of the thermophilic bacterium Rhodothermus marinus: Biosynthesis and regulation MICRO’05:BIOTEC’05, 30 Nov-3 Dec, 2005, Póvoa do Varzim, Portugal.
(Póvoa do Varzim, Portugal)
2004/09/20 Specialized roles of the two pathways for the synthesis of mannosylglycerate in osmoadaptation and thermoadaptation of Rhodothermus marinus The 5th international conference on extremophiles, 19-23, September, 2004, Cambridge, Maryland, EUA.
(Maryland, United States)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023 - Current Jeinny Caetano (Undergraduate student) Análise da presença de celulose em ETAR: Caso de estudo ETAR Setúbal
Supervisor
Instituto Politécnico de Setúbal, Portugal
2023 - 2023 Fábio Guerreiro (Undergraduate Student) Produção de uma Ração com Proteína de Cavala para Robalos e Douradas
Supervisor
Instituto Politécnico de Setúbal, Portugal
2023 - 2023 Diogo Colimão (Undergraduate Student) Produção de ração para aquacultura
Supervisor
Instituto Politécnico de Setúbal, Portugal
2020 - 2020 André Magalhães (Master Student) Exploiting the healing capacity of nature´s microbiomes for improved fish well-being in aquaculture
Co-supervisor of André Magalhães
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
2013 - 2018 Nádia Castanheira (PhD Student) Nitrogen-fixing biofertilizers for gramineous crops
Supervisor of Nádia Castanheira
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2014 - 2017 Cristiana Faria (PhD Student) Development of cell factories for the efficient production of mannosylglycerate, a thermolyte with great potential in biotechnology
Co-supervisor of Cristiana Faria
Universidade Nova de Lisboa, Portugal
2010 - 2014 Ana M Esteves (PhD Student) Unravelling the regulatory mechanisms in thermo-adaptation of hyperthermophilic archaea
Co-supervisor of Ana M Esteves
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2013 - 2013 Rute Pinto (Undergraduate Student) Cloning, expression and purification of a protein involved in the synthesis of a compound accumulated in heat tress response in hyperthermophiles.
Supervisor of Rute Pinto
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2007 - 2011 Marta V Rodrigues (PhD Student) Heat Stress Adaptation in Hyperthermophiles: Biosynthesis of Inositol-Containing Compatible Solutes
Co-supervisor of Marta V Rodrigues
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2009 - 2010 Cristiana Silva Faria (Master Student) Engineering Saccharomyces cerevisiae for the production of mannosylglycerate - a yeast model for assessing its application in protein stabilization
Co-supervisor of Cristiana Faria
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2008 - 2009 Sónia Neto (Master Student) Unravelling Cell-to-Cell Communication in Archaea
Co-supervisor of Sónia Neto
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2006 - 2006 Mafalda Henriques (Undergraduate Student) Bifunctional CTP:inositol-1-phosphate cytidylyltransferase/ CDP inositol:inositol-1-phosphate transferase, the key enzyme for di-myo-inositol-phosphate synthesis in several (hyper)thermophiles
Co-supervisor of Mafalda Henriques
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023 - 2023 "A Celebration of Structural Biology" 14 April 2023, Academia da Ciências de Lisboa, Lisbon, Portugal, Organization: Maria Salomé Pais, Helena Santos, Nuno Borges e Ana Esteves. (2023 - 2023)
Seminar (Co-organisor)
 Academia das Ciências de Lisboa, Portugal
2014 - 2014 "Bioprospecting hot springs in Azores Meeting" October 2014, CiiMAR, Porto, Portugal. H. Santos, V. Vasconcelos, N. Borges, F. do Valle. (2014 - 2014)
Meeting (Co-organisor)
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2010/09/12 - 2010/09/16 The 8th International Conference on Extremophiles, September, 12-16, 2010, Ponta Delgada, Azores, Portugal. H. Santos (Chair), N. Borges (Co-chair), P. Lamosa (Co-chair). (2010/09/12 - 2010/09/16)
Congress (Co-organisor)
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023 - 2023 SIMBA - Sustainable Innovation of Microbiome Applications in the Food System, University of Copenhagen, Denmark, 28 September 2023.
Symposium
 SIMBA - Sustainable Innovation of Microbiome Applications in the Food System
IT-Universitet i København, Denmark
2023 - 2023 LIFE INVASAQUA organizado pelo CINEA-IPS (Escola Superior de Tecnologia de Setúbal, IPS) e LIFE INVASAQUA (Universidade de Évora/MARE/ARNET), 10 março 2023
Symposium
 LIFE INVASAQUA
Instituto Politécnico de Setúbal, Portugal
2019 - 2019 Keep in Touch 2019, May 23, 2019, Instituto Superior Técnico, Lisbon, Portugal
Other
 Keep in Touch 2019
Universidade de Lisboa Instituto Superior Técnico, Portugal
2019 - 2019 Dia do Mar, Museu Nacional de História Natural e da Ciência, 16 November 2019, Lisbon, Portugal Dia do Mar
Museu Nacional de História Natural e da Ciência, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2019/12 Patricia Lobato Calafate Paula, Assessment of antimicrobial activities of marine bacteria against human pathogens
(Thesis) Main arguer
 Patricia Lobato Calafate Paula (Master)
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2023 - Current Reviews in Aquaculture (1753-5123) wiley
2022 - Current Scientific Reports (2045-2322) Nature
2021 - Current 3 Biotech (2190-5738) Springer
2021 - Current Microbiome (2049-2618) Springer Nature
2009 - Current Extremophiles (1433-4909) Springer-Verlag
2009 - Current Research in Microbiology (0923-2508) Elsevier

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2024 - Current Co-coordinator and teaches laboratory practical in the Curricular Unit “Food Safety in Aquaculture" (Mestrado) Instituto Politécnico de Setúbal Escola Superior de Tecnologia de Setúbal, Portugal
2022 - Current Coordinator and teaches theory in the Curricular Unit “Environmental and food microbiology" (Curso Técnico Superior Profissional) Instituto Politécnico de Setúbal Escola Superior de Tecnologia de Setúbal, Portugal
2021 - Current Coordinator and teaches theory in the Curricular Unit "Environmental Microbiology" (Licenciatura) Instituto Politécnico de Setúbal Escola Superior de Tecnologia de Setúbal, Portugal
2022 - 2022 Teaches laboratory practical in the Curricular Unit "Biochemistry" (Licenciatura) Instituto Politécnico de Setúbal Escola Superior de Tecnologia de Setúbal, Portugal
2005 - 2005 The Role of Compatible Solutes in Osmoadaptation and Thermoadaptation of the Thermophilic Bacterium Rhodothermus marinus (Module: Microbiology of Extreme Environments) (Doutoramento) Centro de Neurociências e Biologia Celular at Coimbra University, Portugal
2005 - 2005 Proteomics: Principles and Applications (Module: Metabolic engineering) (Licenciatura) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Distinctions

Award

2007 Prémio Câmara Pestana 2007
Instituto Bacteriológico Câmara Pestana and GlaxoSmithKline, Portugal