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Identification

Personal identification

Full name
Maria Inês Paiva da Silva Leitão

Citation names

  • Maria Inês P. S. Leitão
  • Ines Leitao
  • M. I. Leitão

Author identifiers

Ciência ID
4C12-BD7A-6F17
ORCID iD
0000-0002-2201-6818
Education
Degree Classification
2018/01 - 2022/09/30
Concluded
 Programa Doutoral em Biociências Moleculares (Doutoramento)
Major in Química Bioorganometálica
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
"Organometallic Nucleosides: Synthesis of Platinum and Palladium complexes bearing N-Heterocyclic carbenes based on nucleosides and their anticancer activity" (THESIS/DISSERTATION)
2017/04 - 2018
Attended
 Programa Doutoral em Química Sustentável (Curso de doutoramento (conclusão de unidades curriculares))
Universidade Nova de Lisboa, Portugal
2012/09 - 2015/05
Concluded
 Química Medicinal (Mestrado)
Universidade do Minho Escola de Ciências, Portugal
"Síntese, atividade antifúngica e padrão de marcação em células de Saccharomyces cerevisiae de novos derivados fluorescentes de benzo[a]fenoxazina (classificação: 18 valores; 60 ECTS)" (THESIS/DISSERTATION)
 17
2007/09 - 2012/07
Concluded
 Licenciatura em Bioquímica (Bacharelato)
Universidade do Porto Faculdade de Ciências, Portugal
"Synthesis and characterization of novel 3,5-diacetyl-1,2,4-triazol and 2,6-diacetylpyridine derivatives and their complexes with Pd(II), Pt(II) and Au(III); optimization of the procedure to study their possible complex-DNA interactions (classificação: 16)" (THESIS/DISSERTATION)
 13
Affiliation

Science

Category
Host institution 		Employer
2015/12 - 2022/12 Researcher (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2013/02 - 2015/11 Research Trainee (Research) Universidade do Minho Escola de Ciências, Portugal
Universidade do Minho Escola de Ciências, Portugal
2011/01 - 2011/07 Research Trainee (Research) Universidad Autónoma de Madrid, Spain
Universidad Autonoma de Madrid Facultad de Ciencias, Spain
2009/09 - 2010/09 Research Trainee (Research) REQUIMTE LAQV Porto, Portugal
Universidade do Porto Faculdade de Ciências, Portugal
Projects

Grant

Designation Funders
2018/01/01 - 2022/05/31 Organometallic Nucleosides: Synthesis of Platinum and Palladium complexes bearing N-Heterocyclic carbenes based on nucleosides and their anticancer activity
PD/BD/135483/2018
COVID/BD/152502/2022
PhD Student Fellow
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2015/12 - 2017/12 On the impact of carbene formation in DNA from metal coordination to anticancer activity
IF/00109/2014/CP1244/CT0007
Research Fellow
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Concluded
2009/09 - 2010/09 Síntese de novos ligandos fluorescentes hexadentados
BII/REQUIMTE/QUIBI-2/2009
Integration into Research Grant Fellow
REQUIMTE LAQV Porto, Portugal
Concluded
Outputs

Publications

Conference abstract
  1. Maria Inês P. S. Leitão; Ana Petronilho. "(Oral communication) Metallated nucleobases - synthesis and base-pairing studies". Paper presented in 11th ITQB NOVA PhD Students' Meeting, Oeiras, 2021.
    Published
  2. Maria Inês P. S. Leitão; Federico Herrera; Ana Petronilho. "(Flash Communication) mRNA caps: C-H oxidative addition of 7-methyguanosine to platinum(0) and antiproliferative activity". Paper presented in International School of Chemistry: Chemistry for everyday life (web edition), Camerino (ITALY), Camerino, 2020.
    Published
  3. Maria Inês P. S. Leitão; Federico Herrera; Ana Petronilho. "Flash Communication: N-Heterocyclic Carbenes Derived From RNA-Caps - Synthesis and Antiproliferative Activity". Paper presented in XIIth International School on Organometallic Chemistry, Castellón, 2019.
    Published
  4. Maria Inês P. S. Leitão (4C12-BD7A-6F17); Nicolaus Giannopoulos; Ana Petronilho. "Flash Communication: Caffeine based Nickel(II) Nheterocyclic carbenes: synthesis and catalytic applications". Paper presented in 12th Inorganic and Bioinorganic Chemistry Conference of SPQ, Porto, 2018.
    Published
  5. Maria Inês P. S. Leitão (4C12-BD7A-6F17); Federico Herrera; Ana Petronilho. "Oral Communication: Guanosine Derived N-Heterocyclic Carbenes: synthesis and applications". Paper presented in 6PYCheM – 6 th Portuguese Young Chemists Meeting, Setúbal, 2018.
    Published
  6. Maria Inês P. S. Leitão (4C12-BD7A-6F17); Federico Herrera; Ana Petronilho. "Poster Communication: Cytotoxic Activity of N-Heterocyclic Carbenes Derived from Guanosine". Paper presented in 12th National Organic Chemistry Meeting – 12ENQO, Coimbra, 2018.
    Published
  7. Ana Petronilho; Maria Inês P. S. Leitão (4C12-BD7A-6F17). "Poster Communication: Synthesis of Palladium and Platinum N-Heterocyclic Carbenes Based on Nucleosides". Paper presented in EuCheMS International Organometallic Conference XXII, Amesterdão, 2017.
    Published
  8. Maria Inês P. S. Leitão (4C12-BD7A-6F17); Ana Petronilho. "Poster Communication: Synthesis of N-Heterocyclic Carbenes Derived from Guanine". Paper presented in 5th CARISMA Meeting – Catalytic Routines for Small Molecule Activation, Lisboa, 2017.
    Published
  9. Ana Petronilho; Maria Inês P. S. Leitão (4C12-BD7A-6F17); Nadésda Traskina. "Oral Communication: Synthetic methodologies for N-Heterocyclic Carbenes derived from nucleosides". Paper presented in 11th Inorganic Chemistry Conference, Sintra, 2016.
    Published
  10. Maria Inês P. S. Leitão (4C12-BD7A-6F17); Ana Petronilho. "Poster Presentation: Synthetic approaches for N-heterocyclic carbenes derived from nucleosides". Paper presented in 42nd International Conference on Coordination Chemistry, Brest, 2016.
    Published
  11. Maria Inês P. S. Leitão (4C12-BD7A-6F17); B. Rama Raju; Maria João Sousa; M. Sameiro T. Gonçalves. "Poster Communication: Staining pattern of nine fluorescent benzo[a]phenoxazine derivatives in Saccharomyces cerevisiae cells: relationship with their antifungal activity". Paper presented in 2nd Symposium on Medicinal Chemistry of University of Minho, Braga, 2015.
  12. Maria Inês P. S. Leitão (4C12-BD7A-6F17); B. Rama Raju; Maria João Sousa; M. Sameiro T. Gonçalves. "Poster Communication: Synthesis, photophysical properties and structure–activity relationship studies of novel benzo[a]phenoxazinium chlorides". Paper presented in XX Encontro Luso-Galego de Química, Porto, 2014.
    Published
  13. Maria Inês P. S. Leitão (4C12-BD7A-6F17); B. Rama Raju; Maria João Sousa; M. Sameiro T. Gonçalves. "Poster Communication: Intracellular distribution of a benzo[a]phenoxazinium chloride in Saccharomyces cerevisiae". Paper presented in III Encontro em Técnicas de Análise e Caracterização Química (III ETCAQ), 2014.
Conference paper
  1. Maria Inês P. S. Leitão (4C12-BD7A-6F17); B. Rama Raju; Maria João Sousa; Paulo J. G. Coutinho; M. Sameiro T. Gonçalves. "Benzo[a]phenoxazinium chlorides functionalized with chloride atoms and/or ester groups.". Paper presented in The 19th International Electronic Conference on Synthetic Organic Chemistry, 2015.
    Published • doi:10.3390/ecsoc-19-a006
  2. Joana Parente; B. Rama Raju; Maria Inês P. S. Leitão (4C12-BD7A-6F17); Paulo J. G. Coutinho; M. Sameiro T. Gonçalves; Maria Inês P. S. Leitão. "New benzo[a]phenoxazines bearing the (4,6-dichloro-1,3,5-triazin-2-yl)amino group: synthesis and photophysical properties". Paper presented in The 19th International Electronic Conference on Synthetic Organic Chemistry, 2015.
    Published • 10.3390/ecsoc-19-a012
  3. Maria Inês P. S. Leitão (4C12-BD7A-6F17); B. Rama Raju; Maria João Sousa; M. Sameiro T. Gonçalves. "Evaluation of newly synthesised benzo[a]phenoxazinium chlorides as fluorescent probes using saccharomyces cerevisiae as model organism". Paper presented in The 18th International Electronic Conference on Synthetic Organic Chemistry, 2014.
    Published • 10.3390/ecsoc-18-b021
  4. Maria Inês P. S. Leitão (4C12-BD7A-6F17); B. Rama Raju; Maria João Sousa; M. Sameiro T. Gonçalves. "Antiproliferative activity of 2,3,6,7-tetrahydro-1H-benzo[a]quinolizino[1,9-hi]phenoxazin-14(5H)-iminium chloride derivatives". Paper presented in The 18th International Electronic Conference on Synthetic Organic Chemistry, 2014.
    Published • 10.3390/ecsoc-18-b027
Journal article
  1. Giulia Francescato; Sofia M. da Silva; Maria Inês P. S. Leitão; Ana Gaspar-Cordeiro; Nikolaos Giannopoulos; Clara S. B. Gomes; Catarina Pimentel; Ana Petronilho. "Nickel N-heterocyclic carbene complexes based on xanthines: Synthesis and antifungal activity on Candida sp.". Applied Organometallic Chemistry (2022): https://doi.org/10.1002/aoc.6687.
    10.1002/aoc.6687
  2. Daniel Machado de Alencar; Juliana Gonçalves; Andreia Vieira; Sofia A. Cerqueira; Cruz Sebastião; Maria Inês P. S. Leitão; Giulia Francescato; et al. "Development of Triazoles and Triazolium Salts Based on AZT and Their Anti-Viral Activity against HIV-1". Molecules (2021): https://doi.org/10.3390/molecules26216720.
    10.3390/molecules26216720
  3. Maria Inês P. S. Leitão; Francescato, G.; Gomes, C.S.B.; Ana Petronilho. Corresponding author: Ana Petronilho. "Synthesis of Platinum(II) N-Heterocyclic Carbenes Based on Adenosine". Molecules 26 (2021): 5384-5395. http://dx.doi.org/10.3390/molecules26175384.
    Open access • 10.3390/molecules26175384
  4. Maria Inês P. S. Leitão; Carmen Gonzalez; Giulia Francescato; Zuzanna Filipiak; Ana Petronilho. "On the reactivity of mRNA Cap0: C-H oxidative addition of 7-methylguanosine to Pt0 and base pairing studies". Chemical Communications 56 87 (2020): 13365-13368. https://doi.org/10.1039/D0CC06075E.
    Published • 10.1039/D0CC06075E
  5. Maria Inês P. S. Leitão; B. Rama Raju; Nuno M. F. S. A. Cerqueira; Maria João Sousa; M. Sameiro T. Gonçalves. "Benzo[a]phenoxazinium chlorides: Synthesis, antifungal activity, in silico studies and evaluation as fluorescent probes". Bioorganic Chemistry 98 103730 (2020): http://dx.doi.org/10.1016/j.bioorg.2020.103730.
    Published • 10.1016/j.bioorg.2020.103730
  6. B. Rama Raju; Maria Inês P. S. Leitão (4C12-BD7A-6F17); Maria João Sousa; Paulo J. G. Coutinho; M. Sameiro T. Gonçalves. "New NIR dyes based on quinolizino[1,9-hi]phenoxazin-6-iminium chlorides: synthesis, photophysics and antifungal activity". Dyes and Pigments 173 107870 (2020): https://doi.org/10.1016/j.dyepig.2019.107870.
    Published • 10.1016/j.dyepig.2019.107870
  7. Filipa Santos; Maria Inês P. S. Leitão (4C12-BD7A-6F17); Ana Rita C. Duarte. "Properties of therapeutic deep eutectic solvents of L-arginine and ethambutol for tuberculosis treatment". Molecules 24 1 (2019): https://doi.org/10.3390/molecules24010055.
    Open access • Published • 10.3390/molecules24010055
  8. Maria Inês P. S. Leitão (4C12-BD7A-6F17); Federico Herrera; Ana Petronilho. "N-Heterocyclic Carbenes Derived from Guanosine: Synthesis and Evidences of Their Antiproliferative Activity". ACS Omega 3 11 (2018): 15653-15656. https://pubs.acs.org/doi/10.1021/acsomega.8b02387.
    Published • 10.1021/acsomega.8b02387
  9. B. Rama Raju; Marcello M. T. Carvalho; Maria Inês P. S. Leitão (4C12-BD7A-6F17); Paulo J. G. Coutinho; M. Sameiro T. Gonçalves. "Synthesis, photophysical characterisation and photostability studies of NIR probes with aliphatic, aromatic and chlorinated terminals in 5-and 9-amino positions of benzo[a]phenoxazines.". Dyes and Pigments 132 (2016): 204-212. https://doi.org/10.1016/j.dyepig.2016.04.049.
    Published • 10.1016/j.dyepig.2016.04.049
  10. Maria Inês P. S. Leitão (4C12-BD7A-6F17); B. Rama Raju; Sarala Naik; Paulo J. G. Coutinho; Maria João Sousa; M. Sameiro T. Gonçalves. "Synthesis and photophysical studies of new benzo[a]phenoxazinium chlorides as potential antifungal agents". Tetrahedron Letters 57 35 (2016): 3936-3941. https://doi.org/10.1016/j.tetlet.2016.07.065.
    Published • 10.1016/j.tetlet.2016.07.065
  11. A. I. Matesanz; Ines Leitao; P. Souza. "Palladium(II) and platinum(II) bis(thiosemicarbazone) complexes of the 2,6-diacetylpyridine series with high cytotoxic activity in cisplatin resistant A2780cisR tumor cells and reduced toxicity.". 125 (2013): 26-31. https://doi.org/10.1016/j.jinorgbio.2013.04.005.
    Published • 10.1016/j.jinorgbio.2013.04.005
Preprint
  1. Maria Inês P. S. Leitão; Orsini, Giulia; Petronilho, Ana. Corresponding author: Petronilho, Ana. "Synthesis and Base Pairing Properties of Platinum(II) Nucleosides Based on Uracil". 2022. http://dx.doi.org/10.26434/chemrxiv-2022-6k01r.
    10.26434/chemrxiv-2022-6k01r
  2. Maria Inês P. S. Leitão; Turos-Cabal, Maria; Sanchez-Sanchez, Ana Maria; Gomes, Clara; martin fernandez, vanesa; Herrera, Federico; Petronilho, Ana. Corresponding author: Petronilho, Ana. "Antitumor Activity and Reductive Stress by Platinum(II) N-Heterocyclic Carbenes based on Guanosine". 2022. http://dx.doi.org/10.26434/chemrxiv-2022-k8c22.
    10.26434/chemrxiv-2022-k8c22

Intellectual property

Patent
  1. M. Sameiro T. Gonçalves; Maria Inês P. S. Leitão (4C12-BD7A-6F17); Maria João Sousa. 2019. "Benzophenoxazine derivatives for diagnosis of neoplasia or infection".