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Ana Luisa Carvalho (ORCID 0000-0001-8368-6666) is Associate Professor and group leader at the CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Portugal. She has 20 years of experience working as a Neuroscientist. The aim of her research is to uncover cellular and molecular mechanisms at the basis of neuronal excitability and synaptic function, and how they are impaired in brain diseases. She has made important contributions to the identification of receptor associated proteins and metabolic hormones that regulate synaptic function and plasticity, and to understanding synaptic dysfunction in neurodevelopmental disorders. She has published over 65 papers (H index= 33; >3850 citations) in high impact journals such as PNAS, Neuron, Nature Communications and J Cell Biology. Ana Luisa has mentored 17 PhD and 19 MSc students and presently coordinates the H2020-MSCA-ITN European Training Network Syn2Psy-Synaptic Dysfunction in Neuropsychiatric Disorders. She has coordinated 12 research grants funded by FCT, the EU or private foundations, and participated in 18 other grants. She was a member of the Scientific Research Council for FCT (2013-16) and is ad hoc reviewer for ERA-NET; Wellcome Trust, BBSR, MRC (UK), NOW (The Netherlands); Fondation Fondamental and INSERM/CNRS (France); FWO (Belgium); Neurological Foundation of New Zealand; FCT (Portugal), among others. She has given 32 invited conferences and participated in >90 PhD juries and in >110 Master degree juries.
Identification

Personal identification

Full name
Ana Luisa Carvalho
Gender
Female

Citation names

  • Carvalho, Ana Luisa

Author identifiers

Ciência ID
4B1C-1981-B81A
ORCID iD
0000-0001-8368-6666
Google Scholar ID
https://scholar.google.com/citations?user=sY4fkfYAAAAJ&hl=en
Researcher Id
K-6367-2013

Email addresses

  • alc@cnc.uc.pt (Professional)

Addresses

  • CNC-Centro de Neurociências e Biologia Celular & Departamento de Ciências da Vida, Universidade de Coimbra. Rua Larga, 3004-504, Coimbra, Coimbra, Portugal (Professional)

Websites

  • https://www.cnc.uc.pt/en/research-group/synapse-biology (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
German Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
1999/04/26
Concluded
Doutoramento em Bioquímica, especialidade de Biologia Molecular (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Modulação da actividade dos receptores AMPA por fosforilação: Estudo da fosforilação da subunidade GluR4" (THESIS/DISSERTATION)
Aprovado por unanimidade
1993
Concluded
Bioquímica (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Photoacoustic Measurements of Porphyrin Triplet-State Quantum Yields and Singlet-Oxygen Efficiencies" (THESIS/DISSERTATION)
17 valores
Affiliation

Science

Category
Host institution
Employer
2009/01/01 - Current Principal Investigator (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
1999/10/01 - 2008/12/31 Researcher (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2006/09/01 - 2007/08/31 Invited Principal Investigator (Research) The University of British Columbia Department of Psychiatry, Canada
1999 - 1999 Postdoc (Research) Universidade de Coimbra Faculdade de Medicina, Portugal
1998 - 1998 Research Trainee (Research) Johns Hopkins University School of Medicine, United States
Johns Hopkins University School of Medicine, United States

Teaching in Higher Education

Category
Host institution
Employer
2019/09/01 - Current Associate Professor (University Teacher) Universidade de Coimbra, Portugal
1999/10/01 - 2019/08/31 Assistant Professor (University Teacher) Universidade de Coimbra, Portugal
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Positions / Appointments

Category
Host institution
Employer
2019/03/25 - Current Vice-President Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2004/10/01 - 2019/08/31 Tenured Assistant Professor Universidade de Coimbra, Portugal

Others

Category
Host institution
Employer
2009/01/01 - Current Group Leader ' Synapse Biology' Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017/11/30 - 2021/09 Coordinator of the Master Degree in Cellular and Molecular Biology Universidade de Coimbra, Portugal
2020/03 - 2020/05/31 Volunteer coordinator of COVID-19 diagnosis team - Clinical tests laboratory Universidade de Coimbra, Portugal
Universidade de Coimbra, Portugal
Projects

Grant

Designation Funders
2021 - 2024/11/30 microSTRESS: Regulation of prefrontal cortical synaptic function and behavior by chronic stress-induced microRNA-186-5p
HR21-01077
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Iniciativa Ibérica de Investigaçao e Inovaçao Biomédica, i4b, laCaixa Foundation/FCT
Ongoing
2021 - 2024 Uncovering the molecular machinery responsible for cargo sorting in neuronal polarization
PTDC/BIA-CEL/2286/2020
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2020 - 2023/11/30 MStar - Potassium channel dysfunction in models of neurodevelopmental disorders
Principal investigator
Iniciativa Ibérica de Investigaçao e Inovaçao Biomédica, i4b, laCaixa Foundation/FCT
Ongoing
2019 - 2023/02 Syn2Psy-Synaptic Dysfunction in Neuropsychiatric Disorders
H2020-MSCA-ITN-2018 (813986)
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
European Commission
Ongoing
2018 - 2021/06 COGNITIVE DISORDERS AS DEFECTS IN SYNAPTIC FUNCTION: INSIGHT FROM HUMAN MUTATIONS IN THE CACNG2 GENE
PTDC/MED-NEU/28541/2017
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018 - 2021/05 Understanding the pathogenesis in CASPR2-antibody autoimmune synaptic encephalitis
PTDC/MED-NEU/29452/2017
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018 - 2021 Molecular tools for Machado-Joseph disease: chaperoning toxic protein conformers in polyglutamine-containing proteins
PTDC/BIA-BFS/31173/2017
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018 - 2021 Alternate SNAPs in neurotransmitter release: from molecular function to neurocognitive dysfunction
PTDC/BIA-CEL/29451/2017
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2017 - 2020 BrainHealth2020
CENTRO-01-0145-FEDER-000008:BrainHealth 2020
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
European Regional Development Fund
Ongoing
2016 - 2018 A role for Contactin-associated proteins 1 and 2 in experience-dependent plasticity
PTDC/NEU-NMC/4888/2014
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2016 - 2018 BEHAVIOR ANALYSES OF MICE EXPRESSING A CACNG2 MUTATION ASSOCIATED WITH INTELLECTUAL DISABILITY
1530
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fondation Jérôme Lejeune
Concluded
2015 - 2018 Schizophrenia as a disruption of developmental homeostatic plasticity: a role for stargazin
23151
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Brain and Behavior Research Foundation
Concluded
2015 - 2018 StrokeTherapy - Plataformas terapêuticas para acidentes vasculares cerebrais
3386
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
European Development Fund
2013 - 2015/11 Effects of the orexigenic peptide ghrelin on glutamatergic synaptic transmission
PTDC/NEU-NMC/1098/2012
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2014 - 2015/09 Hunger wisdom: ghrelin modulation of adult neurogenesis and its relationship with memory
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2014 - 2015/09 Ageing@Coimbra: A Co-location Centre in the European Knowledge and Innovation Network for Active and Healthy Ageing
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013 - 2015/09 A Novel Model for Schizophrenia: Defects in Stargazin-Mediated Homeostatic Plasticity.
PTDC/NEU-NMC/0750/2012
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011 - 2014/06 Regulation by phosphorylation of ataxin-3, the mutated protein in Machado Joseph Disease
PTDC/SAU-NMC/110602/2009
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010 - 2013/12 Molecular Mechanisms of Synaptic Traffic of Glutamate Receptors of the NMDA Type
PTDC/SAU-NEU/099440/2008
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011 - 2013/06 Regulation of the stability of the messenger RNA for the GluR1 subunit of glutamate receptors
PTDC/BIA-BCM/113738/2009
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2009 - 2011/12 Implementation of a Nacional Facility for DNA Microarrays: Phase II
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008 - 2011/03 Role of cortactin in the cellular trafficking of AMPA-type glutamate receptors
PTDC/BIA-BCM/71789/2006
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2007 - 2010/12 Regulation of AMPA receptors by hyperglycemia in the retina
PTDC/SAU-NEU/671228/2006
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2007 - 2010/04 Cleavage of the vesicular glutamate (VGLUT) and GABA (VGAT) transporters under excitotoxic conditions: identification of the cleavage sites and functional implications
PTDC/SAU-NEU/65846/2006
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2005 - 2008/12 Molecular determinants of ataxin-3 aggregation and toxicity in Machado-Joseph´s disease
POCI/SAU-MMO/60156/2004
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008 - 2008 Molecular mechanisms coupling Ca2+-permeable AMPA receptors to excitotoxic signalling pathways
NA
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Biogen Portugal
Concluded
2005 - 2007/12 Driving AMPA receptors into synapses: role of interacting proteins in the delivery of GluR4- and GluR2L-containing AMPA receptors
POCI/SAU-NEU/58955/2004
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2003 - 2007 Regulation of the expression of ionotropic glutamate receptors by brain-derived neurotrophic factor (BDNF) in hippocampal neurons
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2002 - 2004 Expression and functional characterization of naturally occuring truncated forms of AMPA-type glutamate receptor subunits
POCTI/MGI/43629/2001
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2000 - 2004 Protective effects of neurotrophins against glutamate toxicity in the hippocampus: intracellular signaling mechanisms
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2021 - 2025/12/31 DYNABrain - DYNAMIC BRAIN FUNCTION: Towards the Understanding and Treatment of Brain Disorders
952422
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
European Commission
Outputs

Publications

Book chapter
  1. Carvalho, A.L.; Silva, A.; Macedo-Ribeiro, S.. "Polyglutamine-independent features in ataxin-3 aggregation and pathogenesis of Machado-Joseph disease". Springer New York, 2018.
    10.1007/978-3-319-71779-1_14
  2. Vieira, M.M.; Carvalho, A.L.. "Necroptosis in cerebral ischemia". In Acute Neuronal Injury: The Role of Excitotoxic Programmed Cell Death Mechanisms: Second Edition, 133-151. 2018.
  3. Carvalho, Ana Luisa; Santos, Sandra D.. "Glutamato". In Neurociências. Portugal: LIDEL, 2017.
    Published
  4. Carvalho, Ana Luisa; Santos, Sandra D.; Ferreira, Joana S. "Plasticidade sináptica". In Neurociências. Portugal: LIDEL, 2017.
    Published
  5. Carvalho, Ana Luisa; Caldeira, Gladys; Peça, João. "Esquizofrenia". In Neurociências, 39-72. Portugal: LIDEL, 2017.
    Published
  6. Ribeiro, S.M.-.; Almeida, L.P.D.; Carvalho, A.L.; Rego, A.C.. "Polyglutamine expansion diseases - The case of machado-joseph disease". In Acute Neuronal Injury: The Role of Excitotoxic Programmed Cell Death Mechanisms: Second Edition. 2007.
    10.1007/978-0-387-70830-0_18
  7. CARVALHO, AP; FERREIRA, IL; CARVALHO, AL; DUARTE, CB; Abood, LG; Lajtha, A. "GLUTAMATE-RECEPTOR MODULATION OF [H-3] GABA RELEASE AND INTRACELLULAR CALCIUM IN CHICK RETINA CELLS". 439-456. 1995.
    10.1111/j.1749-6632.1995.tb17504.x
Journal article
  1. Caldeira, G. L.; Inácio, A. S.; Beltrão, N.; Barreto, C. A. V.; Rodrigues, M. V.; Rondão, T.; Macedo, R.; et al. "Aberrant hippocampal transmission and behavior in mice with a stargazin mutation linked to intellectual disability". Molecular Psychiatry (2022): http://dx.doi.org/10.1038/s41380-022-01487-w.
    10.1038/s41380-022-01487-w
  2. Ana Luisa Carvalho; Dominique Fernandes. "It takes two to tango: Concerted protein translation and degradation necessary for synaptic scaling". PLOS Biology (2021): https://doi.org/10.1371/journal.pbio.3001448.
    10.1371/journal.pbio.3001448
  3. Joana S. Ferreira; Blanka Kellermayer; Ana Luísa Carvalho; Laurent Groc. "Interplay between NMDA receptor dynamics and the synaptic proteasome". European Journal of Neuroscience 54 6 (2021): 6000-6011. https://doi.org/10.1111/ejn.15427.
    10.1111/ejn.15427
  4. Ribeiro, Luís F.; Catarino, Tatiana; Carvalho, Mário; Cortes, Luísa; Santos, Sandra D.; Opazo, Patricio O.; Ribeiro, Lyn Rosenbrier; et al. "Ligand-independent activity of the ghrelin receptor modulates AMPA receptor trafficking and supports memory formation". Science Signaling 14 670 (2021): eabb1953. http://dx.doi.org/10.1126/scisignal.abb1953.
    Open access • 10.1126/scisignal.abb1953
  5. Edfawy, Mohamed; Guedes, Joana R.; Pereira, Marta I.; Laranjo, Mariana; Carvalho, Mário J.; Gao, Xian; Ferreira, Pedro A.; et al. "Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice". Nature Communications 10 1 (2019): http://dx.doi.org/10.1038/s41467-019-09382-9.
    10.1038/s41467-019-09382-9
  6. Mariline M. Silva; Beatriz Rodrigues; Joana Fernandes; Sandra D. Santos; Laura Carreto; Manuel A. S. Santos; Paulo Pinheiro; et al. "MicroRNA-186-5p controls GluA2 surface expression and synaptic scaling in hippocampal neurons". Proceedings of the National Academy of Sciences 116 12 (2019): 5727-5736. https://doi.org/10.1073/pnas.1900338116.
    Published • 10.1073/pnas.1900338116
  7. Dominique Fernandes; Sandra D Santos; Ester Coutinho; Jessica L Whitt; Nuno Beltrão; Tiago Rondão; M Isabel Leite; et al. "Disrupted AMPA Receptor Function upon Genetic- or Antibody-Mediated Loss of Autism-Associated CASPR2". Cerebral Cortex (2019): https://doi.org/10.1093/cercor/bhz032.
    10.1093/cercor/bhz032
  8. Serrenho, D.; Santos, S.D.; Carvalho, A.L.. "The role of ghrelin in regulating synaptic function and plasticity of feeding-associated circuits". Frontiers in Cellular Neuroscience 13 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85068476880&partnerID=MN8TOARS.
    10.3389/fncel.2019.00205
  9. Lima Caldeira, G.; Peça, J.; Carvalho, A.L.. "New insights on synaptic dysfunction in neuropsychiatric disorders". Current Opinion in Neurobiology 57 (2019): 62-70. http://www.scopus.com/inward/record.url?eid=2-s2.0-85061115086&partnerID=MN8TOARS.
    10.1016/j.conb.2019.01.004
  10. Morató, X.; Luján, R.; Gonçalves, N.; Watanabe, M.; Altafaj, X.; Carvalho, A.L.; Fernández-Dueñas, V.; Cunha, R.A.; Ciruela, F.. "Metabotropic glutamate type 5 receptor requires contactin-associated protein 1 to control memory formation". Human Molecular Genetics 27 20 (2018): 3528-3541. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054354803&partnerID=MN8TOARS.
    10.1093/hmg/ddy264
  11. Louros, S.R.; Caldeira, G.L.; Carvalho, A.L.. "Stargazin Dephosphorylation Mediates Homeostatic Synaptic Downscaling of Excitatory Synapses". Frontiers in Molecular Neuroscience 11 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85054810796&partnerID=MN8TOARS.
    10.3389/fnmol.2018.00328
  12. Kellermayer, B.; Ferreira, J.S.; Dupuis, J.; Levet, F.; Grillo-Bosch, D.; Bard, L.; Linarès-Loyez, J.; et al. "Differential Nanoscale Topography and Functional Role of GluN2-NMDA Receptor Subtypes at Glutamatergic Synapses". Neuron 100 1 (2018): 106-119.e7. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054706658&partnerID=MN8TOARS.
    10.1016/j.neuron.2018.09.012
  13. Dominique Fernandes; Ana Luísa Carvalho. "Mechanisms of homeostatic plasticity in the excitatory synapse". Journal of Neurochemistry (2016): http://dx.doi.org/10.1111/jnc.13687.
    10.1111/jnc.13687
  14. Carlos B. Duarte; Ana Luisa Carvalho. "7th ISN special neurochemistry conference ‘Synaptic function and dysfunction in brain diseases’". Journal of Neurochemistry (2016): http://dx.doi.org/10.1111/jnc.13839.
    10.1111/jnc.13839
  15. Vieira, M.M.; Schmidt, J.; Ferreira, J.S.; She, K.; Oku, S.; Mele, M.; Santos, A.E.; et al. "Multiple domains in the C-terminus of NMDA receptor GluN2B subunit contribute to neuronal death following in vitro ischemia". Neurobiology of Disease 89 (2016): 223-234. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959360132&partnerID=MN8TOARS.
    10.1016/j.nbd.2015.11.007
  16. Matos, C.A.; Nóbrega, C.; Louros, S.R.; Almeida, B.; Ferreiro, E.; Valero, J.; De Almeida, L.P.; Macedo-Ribeiro, S.; Carvalho, A.L.. "Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models". Journal of Cell Biology 212 4 (2016): 465-480. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959536774&partnerID=MN8TOARS.
    10.1083/jcb.201506025
  17. Caldeira, Margarida; Ferreira, Joana; Carvalho, Ana; Duarte, Carlos. "Biotinylation and Purification of Plasma Membrane-associated Proteins from Rodent Cultured Neurons". BIO-PROTOCOL 6 10 (2016): http://dx.doi.org/10.21769/bioprotoc.1807.
    10.21769/bioprotoc.1807
  18. Ferreira, J.S.; Schmidt, J.; Rio, P.; Águas, R.; Rooyakkers, A.; Li, K.W.; Smit, A.B.; Craig, A.M.; Carvalho, A.L.. "GluN2B-containing NMDA receptors regulate AMPA receptor traffic through anchoring of the synaptic proteasome". Journal of Neuroscience 35 22 (2015): 8462-8479. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930427217&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.3567-14.2015
  19. Ferreira, I.L.; Ferreiro, E.; Schmidt, J.; Cardoso, J.M.; Pereira, C.M.F.; Carvalho, A.L.; Oliveira, C.R.; Rego, A.C.. "Aß and NMDAR activation cause mitochondrial dysfunction involving ER calcium release". Neurobiology of Aging 36 2 (2015): 680-692. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922927392&partnerID=MN8TOARS.
    10.1016/j.neurobiolaging.2014.09.006
  20. Almeida, B.; Abreu, I.A.; Matos, C.A.; Fraga, J.S.; Fernandes, S.; Macedo, M.G.; Gutiérrez-Gallego, R.; et al. "SUMOylation of the brain-predominant Ataxin-3 isoform modulates its interaction with p97". Biochimica et Biophysica Acta - Molecular Basis of Disease 1852 9 (2015): 1950-1959. http://www.scopus.com/inward/record.url?eid=2-s2.0-84955513053&partnerID=MN8TOARS.
    10.1016/j.bbadis.2015.06.010
  21. Ribeiro, L.F.; Catarino, T.; Santos, S.D.; Benoist, M.; Van Leeuwen, J.F.; Esteban, J.A.; Carvalho, A.L.. "Ghrelin triggers the synaptic incorporation of AMPA receptors in the hippocampus". Proceedings of the National Academy of Sciences of the United States of America 111 1 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84891958005&partnerID=MN8TOARS.
    10.1073/pnas.1313798111
  22. Castilho, A.F.; Liberal, J.T.; Baptista, F.I.; Gaspar, J.M.; Carvalho, A.L.; Ambrósio, A.F.. "Diabetes causes transient changes in the composition and phosphorylation of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors and interaction with auxiliary proteins in the rat retina". Molecular Vision 20 (2014): 894-907. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903118075&partnerID=MN8TOARS.
  23. Fernandes, J.; Vieira, M.; Carreto, L.; Santos, M.A.S.; Duarte, C.B.; Carvalho, A.L.; Santos, A.E.. "In vitro ischemia triggers a transcriptional response to down-regulate synaptic proteins in hippocampal neurons". PLoS ONE 9 6 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84903512303&partnerID=MN8TOARS.
    10.1371/journal.pone.0099958
  24. Vieira, M.; Fernandes, J.; Carreto, L.; Anuncibay-Soto, B.; Santos, M.; Han, J.; Fernández-López, A.; et al. "Ischemic insults induce necroptotic cell death in hippocampal neurons through the up-regulation of endogenous RIP3". Neurobiology of Disease 68 (2014): 26-36. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899850247&partnerID=MN8TOARS.
    10.1016/j.nbd.2014.04.002
  25. Louros, S.; Hooks, B.; Litvina, L.; Carvalho, A.; Chen, C.. "A role for stargazin in experience-dependent plasticity". Cell Reports 7 5 (2014): 1614-1625. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902344846&partnerID=MN8TOARS.
    10.1016/j.celrep.2014.04.054
  26. Mota, S.I.; Ferreira, I.L.; Valero, J.; Ferreiro, E.; Carvalho, A.L.; Oliveira, C.R.; Rego, A.C.. "Impaired Src signaling and post-synaptic actin polymerization in Alzheimer's disease mice hippocampus - Linking NMDA receptors and the reelin pathway". Experimental Neurology 261 (2014): 698-709. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908339906&partnerID=MN8TOARS.
    10.1016/j.expneurol.2014.07.023
  27. Catarino, T.; Ribeiro, L.; Santos, S.D.; Carvalho, A.L.. "Regulation of synapse composition by protein acetylation: The role of acetylated cortactin". Journal of Cell Science 126 1 (2013): 149-162. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875621271&partnerID=MN8TOARS.
    10.1242/jcs.110742
  28. She, Kevin; Ferreira, Joana S.; Carvalho, Ana Luisa; Craig, Ann Marie. "Glutamate Binding to the GluN2B Subunit Controls Surface Trafficking of N-Methyl-D-aspartate (NMDA) Receptors". Journal of Biological Chemistry 287 33 (2012): 27432-27445.
    10.1074/jbc.M112.345108
  29. Castilho, A.F.; Liberal, J.T.; Baptista, F.I.; Gaspar, J.M.; Carvalho, A.L.; Ambrósio, A.F.. "Elevated glucose concentration changes the content and cellular localization of AMPA receptors in the retina but not in the hippocampus". Neuroscience 219 (2012): 23-32. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864022057&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2012.05.056
  30. Santos, S.D.; Iuliano, O.; Ribeiro, L.; Veran, J.; Ferreira, J.S.; Rio, P.; Mulle, C.; Duarte, C.B.; Carvalho, A.L.. "Contactin-associated protein 1 (Caspr1) regulates the traffic and synaptic content of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors". Journal of Biological Chemistry 287 9 (2012): 6868-6877. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857468361&partnerID=MN8TOARS.
    10.1074/jbc.M111.322909
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  33. Ferreira, J.S.; Rooyakkers, A.; She, K.; Ribeiro, L.; Carvalho, A.L.; Craig, A.M.. "Activity and protein kinase C regulate synaptic accumulation of N-Methyl-D-aspartate (NMDA) receptors independently of GluN1 splice variant". Journal of Biological Chemistry 286 32 (2011): 28331-28342. http://www.scopus.com/inward/record.url?eid=2-s2.0-80051515440&partnerID=MN8TOARS.
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  45. Caldeira, M.V.; Melo, C.V.; Pereira, D.B.; Carvalho, R.F.; Carvalho, A.L.; Duarte, C.B.. "BDNF regulates the expression and traffic of NMDA receptors in cultured hippocampal neurons". Molecular and Cellular Neuroscience 35 2 (2007): 208-219. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249712975&partnerID=MN8TOARS.
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  46. Caldeira, M.V.; Melo, C.V.; Pereira, D.B.; Carvalho, R.; Correia, S.S.; Backos, D.S.; Carvalho, A.L.; Esteban, J.A.; Duarte, C.B.. "Brain-derived neurotrophic factor regulates the expression and synaptic delivery of a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits in hippocampal neurons". Journal of Biological Chemistry 282 17 (2007): 12619-12628. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250329980&partnerID=MN8TOARS.
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  48. Gomes, A.R.; Correia, S.S.; Esteban, J.A.; Duarte, C.B.; Carvalho, A.L.. "PKC anchoring to GluR4 AMPA receptor subunit modulates PKC-driven receptor phosphorylation and surface expression". Traffic 8 3 (2007): 259-269. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247490214&partnerID=MN8TOARS.
    10.1111/j.1600-0854.2006.00521.x
  49. Cortes, L.; Carvalho, A.L.; Todo-Bom, A.; Faro, C.; Pires, E.; Veríssimo, P.. "Purification of a novel aminopeptidase from the pollen of Parietaria judaica that alters epithelial integrity and degrades neuropeptides". Journal of Allergy and Clinical Immunology 118 4 (2006): 878-884. http://www.scopus.com/inward/record.url?eid=2-s2.0-33749349447&partnerID=MN8TOARS.
    10.1016/j.jaci.2006.05.029
  50. Santos, A.E.; Duarte, C.B.; Iizuka, M.; Barsoumian, E.L.; Ham, J.; Lopes, M.C.; Carvalho, A.P.; Carvalho, A.L.. "Excitotoxicity mediated by Ca2+-permeable GluR4-containing AMPA receptors involves the AP-1 transcription factor". Cell Death and Differentiation 13 4 (2006): 652-660. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644935364&partnerID=MN8TOARS.
    10.1038/sj.cdd.4401785
  51. Eulálio, A.; Nunes-Correia, I.; Carvalho, A.L.; Faro, C.; Citovsky, V.; Salas, J.; Salas, M.L.; Simões, S.; Pedroso De Lima, M.C.. "Nuclear export of African swine fever virus p37 protein occurs through two distinct pathways and is mediated by three independent signals". Journal of Virology 80 3 (2006): 1393-1404. http://www.scopus.com/inward/record.url?eid=2-s2.0-31144441675&partnerID=MN8TOARS.
    10.1128/JVI.80.3.1393-1404.2006
  52. Gomes, A.R.; Cunha, P.; Nuriya, M.; Faro, C.J.; Huganir, R.L.; Pires, E.V.; Carvalho, A.L.; Duarte, C.B.. "Metabotropic glutamate and dopamine receptors co-regulate AMPA receptor activity through PKA in cultured chick retinal neurones: Effect on GluR4 phosphorylation and surface expression". Journal of Neurochemistry 90 3 (2004): 673-682. http://www.scopus.com/inward/record.url?eid=2-s2.0-3342901599&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2004.02519.x
  53. Eulálio, A.; Nunes-Correia, I.; Carvalho, A.L.; Faro, C.; Citovsky, V.; Simões, S.; De Lima, M.C.P.. "Two African swine fever virus proteins derived from a common precursor exhibit different nucleocytoplasmic transport activities". Journal of Virology 78 18 (2004): 9731-9739. http://www.scopus.com/inward/record.url?eid=2-s2.0-4444281591&partnerID=MN8TOARS.
    10.1128/JVI.78.18.9731-9739.2004
  54. Fernandes, R.; Carvalho, A.L.; Kumagai, A.; Seica, R.; Hosoya, K.-I.; Terasaki, T.; Murta, J.; Pereira, P.; Faro, C.. "Downregulation of retinal GLUT1 in diabetes by ubiquitinylation". Molecular Vision 10 (2004): 618-628. http://www.scopus.com/inward/record.url?eid=2-s2.0-16544391719&partnerID=MN8TOARS.
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Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/12/06 Aberrant hippocampal transmission and behaviour in mice with a stargazin mutation linked to intellectual disability Mini-Symposium IINS - University of Bordeaux
Daniel Choquet (Bordeaux, France)
2021/10/04 Aberrant hippocampal transmission and behaviour in mice with a stargazin mutation linked to intellectual disability “CURRENT TRENDS IN BIOMEDICINE” - THE SYNAPTIC DIMENSION OF BRAIN DISORDERS
Universidad Internacional de Andalucia (Baeza, Spain)
2021/07/05 Ligand-independent activity of the ghrelin receptor modulates AMPA receptor trafficking and supports memory formation POST-TRANSLATIONAL MODIFICATIONS IN NEURONAL PHYSIOLOGY AND BRAIN DISORDERS
HUMANITAS Research Hospital/ National Research Council of Italy (Italy)
2020/11/11 AMPA receptor dysfunction in cognitive disorders CEDOC Seminar Series, NOVA University
Cláudia Almeida (Lisbon, Portugal)
2020/09 AMPA receptor dysfunction in congnitive disorders World Wide Neuro - Virtual Events in Neuroscience (https://www.world-wide.org/Neuro/)
Gaia Novarino
2020/01/29 AMPA receptor dysfunction in cognitive disorders European Neuroscience Institute (ENI) Seminar Series
Ira Milosevic (Göttingen, Germany)
2019/03 AMPA receptor dysfunction in cognitive disorders Centre for Discovery Brain Sciences Seminar Series, University of Edimburgh
Emily Osterweil (Edimburgh, United Kingdom)
2019/02 Synaptic dysfunction in neuropsychiatric disorders iBiMED Seminar Series, University of Aveiro
Ramiro Almeida (Aveiro, Portugal)
2018/09 Synaptic dysfunction in neuropsychiatric disorders 1st Retreat of the Neurobiology and Neurologic Disorders Integrative Program, I3S, University of Porto
João Relvas (Porto, Portugal)
2017/12 AMPA receptor dysfunction in cognitive disorders 6th European Synapse Meeting
European Synapse Meeting (Milan, Italy)
2017/10 Cognitive disorders as defects in synaptic function: insight from human mutations in the CACNG2 gene FEBS3+ - 1st Joint Meeting of the French-Portuguese-Spanish Biochemical and Molecular Biology Societies
(Barcelona, Spain)
2016/06 Cell adhesion contactin-associated proteins mediate homeostatic experience-dependent synaptic plasticity 7th ISN meeting "Synaptic function and dysfunction in brain diseases
International Society for Neurochemistry (Coimbra, Portugal)
2016/03 Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models 10th World Congress on Controversies in Neurology (CONy)
CONy (Lisbon, Portugal)
2015/10 Molecular Mechanisms for Regulating Excitatory Synapses Seminar Series at the Departamento di Neuroscienze, School of Medicine, University of Naples "Federico II"
Lorella Canzoniero (Naples, Italy)
2015/05 Receptors, synapses and memory IBMC-Instituto de Biologia Molecular e Celular, University
Sandra Macedo-Ribeiro (Porto)
2015/04 Molecular Mechanisms for Regulating Excitatory Synapses Seminar Series IDIBELL-Bellvitge Institute for Biomedical Research
Jordi Llorens (Barcelona, Spain)
2015/01 Mechanisms of glutamate receptor traffic Seminar Series Champalimaud Foundation
Inbal Israely (Lisbon)
2014/12 NMDA receptors regulate AMPA receptor traffic through anchoring of the synaptic proteasome Seminar Series Interdisciplinary Neuroscience Institute
Nathalie Sans (Bordeaux, France)
2013/05 Modulation of hippocampal glutamatergic synapses by ghrelin XIII Reunião da Sociedade Portuguesa de Neurociências (SPN)
Sociedade Portuguesa de Neurociências (Luso, Portugal)
2013/04 Modulation of hippocampal glutamatergic synapses by ghrelin British Neuroscience Association (BNA) Meeting
British Neuroscience Association (BNA) (London, United Kingdom)
2013/02 Modulators of glutamatergic synapses in the hippocampus Seminar Series IMM-Instituto Medicina Molecular, Universidade de Lisboa
IMM-Instituto Medicina Molecular, Universidade de Lisboa (Lisbon, Portugal)
2012/11 Modulation of hippocampal glutamatergic synapses by ghrelin Seminar Series Interdisciplinary Neuroscience Institute
Interdisciplinary Neuroscience Institute (Bordeaux, France)
2012/04 Modulation of hippocampal glutamatergic synapses by the appetite-stimulating hormone Ghrelin SINAL 2012
SINAL (Braga, Portugal)
2011/05 Mechanisms of synaptic traffic of glutamate receptors Seminar at Biogem
Biogem (Ariano, Italy)
2007/07 AMPA-type glutamate receptors: regulation by BDNF, interacting proteins and alternative splicing Life Sciences 2007
Biochemical Society & British Pharmacological Society and The Physiological Society (Glasgow, United Kingdom)
2006/11 Phosphorylation and traffic of glutamate receptors of the AMPA type Seminar Series Brain Research Centre, University of British Columbia
Ann Marie Craig (Vancouver, Canada)
2005/03 AMPA receptor phosphorylation and trafficking 25th European Winter Conference on Brain Research
European Winter Conference on Brain Research (Les Arcs, France)
2004/12 Role of glutamate receptor trafficking in synaptic regulation XIV National Biochemistry Meeting
Portuguese Biochemistry Society (Vilamoura, Portugal)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2019 - Current Cerebellar dysfunction in neuropsychiatric disorders: insights from human mutations in Stargazin
Supervisor of Nuno Beltrão Marques
Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2019 - Current Role of prefrontal cortex circuit defects in cognitive alterations in Intellectual Disability and Schizophrenia mouse models
Supervisor of Orsolya Antal
Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2017 - Current Stargazin as a regulator of neuronal excitability
Supervisor of Marina Rodrigues
Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2017 - Current Synaptic regulation by chronic stress-induced miRNA
Supervisor of Beatriz Rodrigues
Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2017 - Current Unraveling the role of ghrelin in cognition: effects on spine dynamics and structural plasticity
Supervisor of Débora Serrenho
Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2014 - 2021/10 Characterization of the Novel Rho-GTPase Activating Protein BPGAP1 in the Central Nervous System
Supervisor of Jeannette Schmidt
Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2019/09 - 2020/12 HIPPOCAMPAL DYSFUNCTION IN ANIMAL MODELS OF NEURODEVELOPMENTAL DISORDERS
Co-supervisor of Renato Rodrigo Macedo
Cellular and Molecular Biology (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019/09 - 2020/11 Exploring the pathogenic mechanisms elicited by antibody-mediated loss of Caspr2 in autoimmune synaptic encephalitis
Co-supervisor of Ana Maria da Graça Fernandes Vasconcelos
Cellular and Molecular Biology (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2015 - 2020/07 Peptides that signal hunger - a new role in memory and social behaviors
Co-supervisor of Mário Jorge da Silva Carvalho
Bioengenharia - Programa MIT-Portugal (PhD)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018 - 2018 2B or not 2B that is the question about the synaptic proteasome in glutamatergic synapses
Supervisor of Rodolfo das Neves Águas
Investigação Biomédica (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2018 - 2018 Stargazin mutations and psychiatric disorders: the case of intellectual disability
Supervisor of Nuno Miguel Beltrão Marques
Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014 - 2018 Super resolution imaging reveals differential organization and regulation of NMDA receptor subtypes
Supervisor of Blanka Kellermayer
Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2013 - 2018 Role of Caspr1 and Caspr2 in the regulation of glutamatergic transmission and synaptic plasticity - implication for disease pathogenesis
Supervisor of Dominique Moreira Fernandes
Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2013 - 2018 Unveiling the role of miRNAs in synaptic plasticity
Supervisor of Mariline Mendes Silva
Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2013/09/05 - 2017/12/22 Dissecting the role of GPRASP2 in autism spectrum disorder and intellectual disability
Co-supervisor of Mohamed Edfawy Soliman Hussien
Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2017 - 2017 ARHGAP8 co-regulates excitatory and inhibitory synapse function
Supervisor of Inês Baião Santos
Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017 - 2017 Behavioral and Biochemical Characterization of Stargazin knock-in mice expressing an Intellectual disability-linked mutation.
Supervisor of Tiago Batista Abrantes Rondão
Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013 - 2017 The role of stargazin in the pathogenesis of psychiatric disorders
Supervisor of Gladys Tarcila Lima Caldeira
Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2016 - 2016 The interactome of stargazin: relevance in neuropsychiatric disorders
Supervisor of Marina Manuela Ventura Rodrigues
Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016 - 2016 miRNAs in the regulation of synaptic function
Supervisor of Beatriz Rodrigues
Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016 - 2016 Ghrelin receptor activation regulates hippocampal spine dynamics
Co-supervisor of Débora Serrenho
Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016 - 2016 Scale for mapping the brain: the role of stargazin in regulating dendritic spine morphology
Co-supervisor of Joana Freitas
Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2010 - 2015 Regulation of ataxin-3 by phosphorylation: relevance for Machado-Joseph disease
Supervisor of Carlos Adriano Albuquerque Andrade de Matos
Biologia (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014 - 2014 Intelligent design of color-tuned ChR2 variants for optogenetics applications
Co-supervisor of Bruno Filipe Pereira da Cruz
Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014 - 2014 Molecular mechanisms of the synaptic and cognitive effects of ghrelin
Co-supervisor of Mário Jorge da Silva Carvalho
Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009 - 2014 Molecular Mechanisms Coupling Calcium-permeable Ampa Receptors to Excitotoxic Signalling Pathways
Co-supervisor of Marta Isabel Dias da Mota Vieira
Ciências e Tecnologias da Saúde (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2009 - 2014 In vitro Ischemia-induced changes in the Transcriptome of Hippocampal Neurons: Neuroprotective Pathways in Brain Ischemia
Co-supervisor of Joana Filipa Coelho Fernandes
Ciências e Tecnologias da Saúde (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2013 - 2013 Effects of ghrelin on hippocampal glutamate receptors and neuronal morphology
Supervisor of J Fiona van Leeuwen
Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009 - 2013 A Link Between Metabolic Signaling and Cognition: The Hippocampal Function of Ghrelin
Supervisor of Luís Filipe da Silva Ribeiro
Biologia (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012 - 2012 Role of ataxin3 aggregation and phosphorylation in the pathogenesis of Machado-Joseph disease
Supervisor of Marilisa Vigorita
Biology (Master)
Università degli Studi del Sannio, Italy
2008 - 2012 Molecular Mechanisms of Synaptic Traffic of Glutamate Receptors of the NMDA Type: Implications in Synaptic Plasticity
Supervisor of Joana Isabel Simões Ferreira
Biociências (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008 - 2012 Synapse Development in a Mouse Model fo ran Autism-Spectrum Disorder
Co-supervisor of João Manuel Assunção Noutel dos Santos
Biologia (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008 - 2012 The Role of Transmembrane Receptor Regulatory Proteins (TARPs) in Synapse Remodeling and Homeostatic Plasticity.
Supervisor of Susana Ribeiro dos Louros
Biologia (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2006 - 2012 Regulation of Synapse Composition by Protein Acrylation: the Role of Acetylated Cortactin
Supervisor of Tatiana Andreia Forjaz Amaral Catarino
Biologia (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2011 - 2011 Post-transcriptional mechanisms of regulation of AMPA receptors: Regulation of GluA1 expression by the Contactin associated protein 1
Supervisor of Dominique Moreira Fernandes
Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2011 - 2011 The GluN2B subunit of NMDA receptors and its role in glutamatergic synapses: Towards the characterization of the proteome of postsynaptic densities from wild-type and GluN2B-null cultured neurons
Supervisor of Pedro Rio
Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2011 - 2011 The role of Caspr1 in AMPA receptor traffic
Supervisor of Olga Iuliano
Biology (Master)
Università degli Studi del Sannio, Italy
2005 - 2011 VGLUT1 and VGLUT2 cleavage under excitotoxic conditions and in cerebral ischemia
Co-supervisor of Andrea Catarina Amaro de Campos Lobo
Biologia (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009 - 2009 Post-Translational Modifications of Ataxin-3, the protein involved in Machado-Joseph disease: Evidences for Phosphorylation and Sumoylation
Supervisor of Carlos Adriano Matos
Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2004 - 2009 Proteomic Analysis of the Interactome of Glutamate Receptors of the Ampa Type: Contactin Associated Protein 1 as a Regulator of Ampa Receptors
Supervisor of Sandra Manuela Domingues dos Santos
Biologia (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2007 - 2007 Excitotoxic mechanisms associated to Ca2+-permeable AMPA receptors: the role of the JNK signaling pathway
Co-supervisor of Marta Mota Vieira
Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Event organisation

Event name
Type of event (Role)
Institution / Organization
2021/12/01 - 2021/12/03 17th Meeting of the Portuguese Neuroscience Society (SPN) (2021/12/01)
Conference (Member of the Organising Committee)
2001 - 2020 Organization of 28 seminars by invited national and international scientists at the CNC-Center for Neuroscience and Cell Biology Seminar Series (2001 - 2020)
Seminar (Co-organisor)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/01/25 - 2018/01/25 Integrating Glial and Neuronal Function (2018/01/25 - 2018/01/25)
Workshop (Co-organisor)
2017/10/23 - 2017/10/26 ‘Synaptic defects in brain diseases’ symposium at the FEBS3+ - 1st joint meeting of the French-Portuguese-Spanish Biochemical and Molecular Biology Societies (2017/10/23 - 2017/10/26)
Symposium (Co-organisor)
2016/06/01 - 2016/06/04 7th ISN meeting ‘Synaptic function and dysfunction in brain diseases’ (2016/06/01 - 2016/06/04)
Conference (Co-organisor)
2013/05/30 - 2013/06/01 13th Meeting of the Portuguese Neuroscience Society (SPN) (2013/05/30 - 2013/06/01)
Conference (Member of the Organising Committee)
2011/04/28 - 2011/04/30 5th SINAL meeting (2011/04/28 - 2011/04/30)
Conference (Member of the Organising Committee)
2001/09/13 - 2001/09/14 7th Meeting of the Portuguese Neuroscience Society (2001/09/13 - 2001/09/14)
Conference (Member of the Organising Committee)

Committee member

Activity description
Role
Institution / Organization
2020/09/01 - Current Member of the scientific council of the Instituto Investigação Interdisciplinar (IIIIUC), University of Coimbra
Member
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2016 - Current Member of the pedagogic council of the Instituto de Investigação Interdisciplinar (IIIUC), University of Coimbra
Member
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2013 - 2016 Member of the Scientific Council of Health and Life Sciences for the Portuguese Research Foudation (Fundação para a Ciência e a Tecnologia - FCT)
Member
Fundação para a Ciência e a Tecnologia, Portugal

Evaluation committee

Activity description
Role
Institution / Organization Funding entity
2010 - Current Grant Reviewer for the following organizations (part I): •Biotechnology and Biological Sciences Research Council (BBSRC, UK) •ERA-NET Neuron (2017, 2018; EU) •Fondation Fondamental (France) •Fundação para a Ciência e a Tecnologia (FCT, Portugal) •iMed.ULisboa Young Investigator Projects for Collaborative Cross-disciplinary Studies (Portugal) •INSERM/CNRS ATIP-Avenir program (France) •Israely Ministry of Health (Israel) •Medical Research Council (MRC, UK) •Netherlands Organization for Scientific Research (NWO, The Netherlands)
Evaluator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2010 - Current Grant reviewer for the following organisations (part II): •Neurological Foundation of New Zealand (New Zealang) •Research Foundation Flanders (FWO, Belgium) •Wellcome Trust (UK)
Evaluator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2005 - Current Adhoc reviewer for the following journals (part I): BMC Genomics, BMC Neuroscience, Brain Research, British J Pharmacolog, Cell Biology International, Cell Death and Disease, Cell Reports, Cellular and Molecular Neurobiology, Cellular and Molecular Life Sciences, Disease Models & Mechanisms, eLIFE, EMBO J, European J Neuroscience, European J Pharmacology, Experimental Eye Research
Evaluator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2005 - Current Adhoc reviewer for the following journals (part II): •Frontiers in Cellular Neuroscience •Frontiers in Molecular Neuroscience •Frontiers in Neuroscience •Frontiers in Neuroscience - Neuropharmacology •Frontiers in Pharmacology •Frontiers in Psychiatry •Frontiers in Synaptic Neuroscience •Hippocampus •Histochemistry and Cell Biology •Human Molecular Genetics •International J of Developmental Neuroscience •International Journal of Neuroscience •iScience •J Cell Physiology •J Cell Science •J Neurochemistry
Evaluator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2005 - Current Adhoc reviewer for the following journals (part III): J Neurophysiology, J Neuroscience, J Neuroscience Research, J Physiology, J Proteome Research, J Neuroscience Research, Learning & Memory, Molecular and Cellular Neuroscience, Molecular Biology of the Cell, Naunyn-Schmiedeberg's Archives of Pharmacology, Neural Plasticity, Neurobiology of Stress, Neuropharmacology, Neuropeptides, Neuroreport, Neuroscience, Neurotoxicity Research, Oncotarget, PLoS One, PLoS Genet, PNAS, Schizophrenia Bulletin . Scientific Reports
Evaluator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2018 - Current Frontiers in Molecular Neuroscience (Review Editor) (1662-5099) Frontiers Media SA
2014 - Current Frontiers in Pharmacology - Neuropharmacology (Review Editor) (1663-9812) Frontiers Media SA

Mentoring / Tutoring

Topic Student name
2021/10 - Current Marie-Curie Individual Fellowship - senior postdoctoral position Luís F. Ribeiro
2017 - Current Post-doctoral fellow Ângela Inácio
2018 - 2022/02 Post-doctoral fellow Dominique Fernandes
2017 - 2021/12 Post-doctoral fellow Gladys Caldeira
2018 - 2020/12 Post-doctoral fellow Mariline Silva
2012 - 2017 Post-doctoral fellow Tatiana Catarino
2012 - 2015 Post-doctoral fellow Susana Louros