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Patrícia Silva is a Research Assistant and integrated member of the Oral Pathology and Rehabilitation Research Unit (UNIPRO) at the University Institute of Health Sciences (IUCS) at CESPU. She is also an Invited Assistant Professor of Human Body Morphology and Functions, and a lecturer in the Oncobiology Advanced Course at the same institution. She is a collaborating researcher at the One Health Toxicology Research Unit (1H-TOXRUN, IUCS-CESPU), where she is a member of the Office of Communication and Public Engagement and the Bibliometric & Financing Office. She completed a pre-Bologna degree in Pathological, Cytological, and Thanatological Anatomy (CESPU) in 2008 and a master¿s degree in Molecular Biology Techniques and Cytomics in Health Science (CESPU) in 2011. In 2017, she completed her PhD in Biomedical Sciences (FCT fellowship SFRH/BD/90744/2012) at the Department of Biomedical Sciences and Medicine at the University of Algarve (Ualg), where she investigated the function, regulation, and therapeutic implications of the Mitotic Checkpoint mechanism. Her PhD research was conducted at the Centre for Biomedical Research (CBMR, Ualg) in collaboration with CESPU. She has previously worked as a pathology anatomy technician at IPATIMUP, and at INEB, where she processed biological samples from mice to evaluate heart injury. Currently, her research interests include the clinical relevance of mitosis regulation and the development of strategies to induce cancer cell death or enhance their sensitivity to current chemotherapeutics agents. She maintains collaborative work with the Faculty of Pharmacy of the University of Porto (FFUP) to characterize small molecules with anti-cancer potential. Recently, she co-authored a book entitled "Mas... o que é o cancro?," with the objective of explaining heath concepts to preschoolers. She has been interested in developing research in the field of health literacy, particularly for early ages. She has published 39 articles in international peer-reviewed journals, mostly in Q1. Additionally, she has authored/co-authored 29 invited/selected talks at national and international meetings, been involved in 22 projects with competitive funding (FCT, Norte2020, CESPU), and co-supervised 20 MSc and graduated students and 2 PhD students.
Identification

Personal identification

Full name
Patrícia Silva
Date of birth
1986/01/01
Gender
Female

Citation names

  • Silva, Patrícia M. A.

Author identifiers

Ciência ID
4B19-7E26-A047
ORCID iD
0000-0002-0694-7321
Researcher Id
AAR-5774-2021
Scopus Author Id
55855611900

Email addresses

  • patricia.silva@cespu.pt (Professional)

Telephones

Telephone
  • 224 157 Ext.: 189 (Professional)

Addresses

  • Rua Central de Gandra, 1317, 4585-116, Gandra, Paredes, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Cell Biology
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Medical and Health Sciences - Health Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Elementary (A2) Upper intermediate (B2) Elementary (A2) Advanced (C1)
French Beginner (A1) Intermediate (B1) Beginner (A1) Elementary (A2) Beginner (A1)
Education
Degree Classification
2022/03/13 - 2022/03/16
Concluded
From 3D light to 3D electron microscopy (virtual) (Outros)
European Molecular Biology Laboratory, Germany
2022/01/20 - 2022/02/17
Concluded
Course in Internal Quality Audits - ISO 9001 (Outros)
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2021/07/22 - 2021/07/23
Concluded
Course in Online Survey Construction (Using LimeSurvey) (Outros)
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2020/05/08 - 2020/05/22
Concluded
Workplace Safety - COVID-19 Prevention Measures (Outros)
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2019/11/04 - 2019/12/21
Concluded
Course in Editing and Processing Scientific Images using GIMP (Outros)
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2019/12/12 - 2019/12/12
Concluded
Course in Integrated Management of Hospital Waste - Module I (Outros)
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2019/11/25 - 2019/12/12
Concluded
Course in Creative and Traditional Management of Bibliographic References using Zotero and Mendeley (Outros)
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2018/05/07 - 2018/05/19
Concluded
Course in Laboratory Animal Science - Category C (Outros)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2013/01 - 2017/09/15
Concluded
Biomedical Sciences (Doutoramento)
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
"The Spindle Assembly Checkpoint: New Insights Into Its Function, Regulation and Therapeutic Implications" (THESIS/DISSERTATION)
Aprovado por unanimidade com distinção e louvor
2016/11/28 - 2016/12/02
Concluded
II Quantitative Fluorescence Microscopy Course (Outros)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014/01/06 - 2014/01/17
Concluded
Biostatistics in Health Sciences Course, 4th Edition (Outros)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2013/12/02 - 2013/12/05
Concluded
Proteomics course: gel based protein separation by twodimensional gel electrophoresis and protein characterization by MALDI-TOF/TOF mass spectrometry. (Outros)
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
2008 - 2011/09/09
Concluded
Molecular Biology and Cytomics Techniques in Health Sciences (Mestrado)
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
"Relação entre a proteína Bub3 do checkpoint mitótico e a proteína motora Dineína durante o alinhamento dos cromossomas na placa metafásica" (THESIS/DISSERTATION)
19 out of 20
2010/10/15 - 2010/10/30
Concluded
Cytopathology Continuous Learning Course (Outros)
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2008/04/11 - 2008/04/12
Concluded
I Advanced Course in Forensic Entomology (Outros)
Universidade do Porto Faculdade de Direito, Portugal

Instituto Nacional de Medicina Legal e Ciências Forenses, Portugal
2004 - 2008
Concluded
Pathological, Cytological, and Thanatological Anatomy (Licenciatura)
Major in Não Aplicável
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
16 out of 20
2007/06/05 - 2007/07/05
Concluded
Criminal Investigation Synthetic Course (Outros)
Universidade Fernando Pessoa, Portugal
Affiliation

Science

Category
Host institution
Employer
2024/03 - Current Auxiliary Researcher (Research) Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
Instituto Universitário de Ciências da Saúde Unidade de Investigação em Patologia e Reabilitação Oral, UNIPRO (IUCS-CESPU)), Portugal
2021 - Current Researcher (Research) Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
Instituto Universitário de Ciências da Saúde Unidade de Investigação em Toxicologia, Portugal
2021 - 2024/03 Research Assistant (Research) Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
UNIPRO – Unidade de Investigação em Patologia e Reabilitação Oral, Instituto Universitário de Ciências da Saúde (IUCS-CESPU), Portugal
2019 - 2021 Research Assistant (Research) Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal

Teaching in Higher Education

Category
Host institution
Employer
2019 - Current Invited Assistant Professor (University Teacher) Instituto Universitário de Ciências da Saúde, Portugal
2008 - 2019 Invited Assistant (University Teacher) Instituto Universitário de Ciências da Saúde, Portugal

Other Careers

Category
Host institution
Employer
2009/04 - 2011/02 Técnico de 2ª Classe (Técnico de Diagnóstico e Terapêutica - Técnico de Anatomia Patológica, Citológica e Tanatológica) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2010/03 - 2010/12 Auxiliar de Preparação de Anatomia Patológica (Técnico de Diagnóstico e Terapêutica - Técnico de Anatomia Patológica, Citológica e Tanatológica) Instituto Nacional de Engenharia Biomédica, Portugal
Instituto Nacional de Engenharia Biomédica, Portugal

Positions / Appointments

Category
Host institution
Employer
2024 - Current Topical Advisory Panel member of the "International Journal of Biomedical Sciences" journal MDPI AG, Switzerland
2021/04 - Current Topical Advisory Panel member of the "Pharmaceutics" journal MDPI AG, Switzerland
2021 - Current Team member of the Office of Communication and Public Engagement (OCPE) of the One Health Toxicology Research Unit (1H-TOXRUN) (https://toxrun.iucs.cespu.pt/?q=content/office-communication-and-public- Instituto Universitário de Ciências da Saúde Unidade de Investigação em Toxicologia, Portugal
2021 - Current Team member of the Bibliometric & Financing Office of the One Health Toxicology Research Unit (1H-TOXRUN) (https://toxrun.iucs.cespu.pt/?q=content/bibliometric-financing-office) Instituto Universitário de Ciências da Saúde Unidade de Investigação em Toxicologia, Portugal
2023/06/01 - 2023/06/02 Editorial Council member of Scientific Letters [2795-5117] - Production Editor of the Book of Abstracts for the II UNIPRO International Congress (1(Sup 2). https://doi.org/10.48797/sl.2023.112) Scientific Letters, Portugal
2023/04/27 - 2023/04/28 Editorial Council member of Scientific Letters [2795-5117] - Production Editor of the Book of Abstracts for the II TOXRUN International Congress (1(Sup 1). https://doi.org/10.48797/sl.2023.111 Scientific Letters, Portugal

Others

Category
Host institution
Employer
2017 - 2021 Editor of IINFACTS News Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
2017 - 2018 Técnica Superior de Investigação (Técnica Superior) Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
2011 - 2011 Técnica Superior de Investigação (Técnica Superior) Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
Projects

Grant

Designation Funders
2013 - 2017/09 The Spindle Assembly Checkpoint: New Insights Into Its Function, Regulation and Therapeutic Implications.
SFRH/BD/90744/2012
PhD Student Fellow
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
Fundação para a Ciência e Tecnologia (FCT)
Concluded

Contract

Designation Funders
2021/01/01 - 2025/12/31 Institute for Health and Bioeconomy
LA/P/0140/2020
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Universidade Nova de Lisboa, Portugal

INESC Microsistemas e Nanotecnologias, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2024/04 - 2025/04 Sneaking Around Science: Promoting Health Scientific Literacy in Preschool
SciPre.com_GI2- CESPU-2023
Principal investigator
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal

UNIPRO – Unidade de Investigação em Patologia e Reabilitação Oral, Instituto Universitário de Ciências da Saúde (IUCS-CESPU), Portugal
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU)
Ongoing
2024/04 - 2025/04 Boosting the Efficacy of Emerging Mitosis-targeted Antitumor Therapies
BeatCancer_GI2- CESPU-2023
Co-Principal Investigator (Co-PI)
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal

UNIPRO – Unidade de Investigação em Patologia e Reabilitação Oral, Instituto Universitário de Ciências da Saúde (IUCS-CESPU), Portugal
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU)
Ongoing
2020/01/01 - 2024/12/31 Applied Molecular Biosciences Unit
UIDP/04378/2020
Universidade Nova de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2020/01/01 - 2024/12/31 Applied Molecular Biosciences Unit
UIDB/04378/2020
Universidade Nova de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022/09/01 - 2023/08/31 Overcoming paclitaxel resistance in ovarian cancer
upPTXovcar-GI2-CESPU-2022
Principal investigator
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU)
Concluded
2022/09/01 - 2023/08/31 The second-generation antimitotics: a second chance?
SGA4Cancer-GI2-CESPU-2022
Co-Principal Investigator (Co-PI)
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU)
Concluded
2022/09/01 - 2023/08/31 Studies of molecular mechanisms of flavonoid derivatives with potential antitumor activity
Flav4Tumor-GI2-CESPU-2022
Researcher
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU)
Ongoing
2021 - 2022 Three-Dimensional Models of Cancer to Increase the Predictive Value of Preclinical Evaluation of Antimitotic Agents.
AntiMitoSphere_APSFCT_IINFACTS_2021
Researcher
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU)
Ongoing
2021 - 2022 Antitumor and antimicrobial activities of chiral derivatives of xanthones and flavonoids.
ActivCHIRAL_PI2RL_IINFACTS_2021
Researcher
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU)
Ongoing
2018/09/01 - 2022 Molecular mechanisms of chromosome segregation
POCI-01-0145-FEDER-030014
Researcher
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal

Centro de Ciências do Mar, Portugal
Fundação para a Ciência e Tecnologia (FCT)
Concluded
2019 - 2021 Biological assessment of debris from oral implants
IMPLDEBRIS-PI-3RL-IINFACTS-2019
Researcher
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU)
2019 - 2021 Chiral derivatives of xanthones and flavonoids: synthesis and biological activity evaluation.
CHIRALBIOACTIVE-PI-3RL-IINFACTS-2019:
Researcher
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
Ongoing
2019 - 2021 Chiral derivatives of xanthones and flavonoids: synthesis and biological activity evaluation.
CHIRALBIOACTIVE-PI-3RL-IINFACTS-2019:
Researcher
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
N/A
2019 - 2020 Targeting the mitotic protein p31comet for cancer therapy
ComeTax-PFT-IINFACTS-2019
Researcher
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU)
Concluded
2018 - 2019 Bub3 and Spindly knockout mediated by CRISPR-Cas9 technology: in vitro characterization and therapeutic potential
CRISPRTech-CESPU-2018
Researcher
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
Cooperativa de Ensino Superior Politécnico e Universitário
Concluded
2018 - 2019 Evaluation of Biologic effects of Laser Treatment of Benign and Potentially Malignant Diseases in Oral Cavity
LASERORAL-CESPU-2018
Researcher
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU)
Concluded
2017/04 - 2018/04 Relating Monocarboxylate Transporters (MCTs) Expression to Macrophage Polarization in Oral Squamous Cell Carcinoma
MacrOral
Researcher
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU)
Concluded
2017/04 - 2018/04 BubR1 as Predictive Biomarker of Malignant Transformation of Oral Potentially Malignant Disorders
BubOral_CESPU2017
Researcher
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU)
2017 - 2018 Anticancer activity of aromatic plant extracts and main terpenoids, synergy with conventional chemotherapeutics
AntiCancerAromTerpen_CESPU_2017
Researcher
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU)
Concluded
2016 - 2018 Navigating through marine-derived fungi: bioprospection and synthesis of bioactive secondary metabolites and analogues as chemotherapic agents.
PTDC/MAR-BIO/4694/2014
Researcher
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Fundação para a Ciência e Tecnologia (FCT)
2016 - 2017 Clinicopathological significance of mitotic protein expression in oral cancer.
MitOralC-CESPU-2016
Researcher
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU)
Concluded
2016 - 2017 The mitotic protein Spindly as a cancer therapeutic target
SpindlyTarget-CESPU-2016
Researcher
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU)
Concluded
2014 - 2015 Therapeutic targeting of the mitotic checkpoint to increase sensitivity of cancer cells to anti-mitotic agents.
CheckTax-CESPU-2014
Researcher
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU)
Concluded
2014 - 2015 Characherisation of HER family heterodimers in oral squamous cell carcinomas using in situ proximity ligation assay
HerPLA-CESPU-2014
Researcher
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU)
Concluded
2011 - 2015 Human Papiloma Virus (HPV) as etiologic agent of oral cancer
05-GCD-CICS-2011
Researcher
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU)
Outputs

Publications

Book
  1. Pinto, Bárbara; Torres, Diana; Silva, Patrícia M. A.. Mas...o que é o cancro?. Portugal: Flamingo Ediçoes. 2024.
    In press
Book chapter
  1. Silva, Patrícia M. A.; Silva, João P. N.; Pinto, Bárbara; Bousbaa, Hassan. Corresponding author: Bousbaa, Hassan. "Time-lapse Imaging to Analyze Cell Fate in Response to Antimitotics.". In Methods in Molecular Biology. New York, United States: Springer Nature, 2024.
    Accepted
Conference poster
  1. João P. N. Silva; Silva, Patrícia; Luís Monteiro ; Bousbaa, Hassan. "Co-inhibition of mitotic kinesins and kinases with BCL-2 family inhibitors enhances cytotoxicity of oral cancer cells". Paper presented in PhD Day 2023 - IUCS-CESPU | "The Impact of Science: How Research Shapes Society?", 2023.
  2. Eliseba Castro; J. Moreira; Patrícia M. A. Silva; L. Saraiva; M. Pinto; H. Bousbaa; H. Cidade. "Biological evaluation of new diarylpentanoid analogues for antitumor activity". Paper presented in Trabalho apresentado em II TOXRUN International Congress. https://doi.org/10.48797/sl.2023.26, 2023.
  3. B. Pinto; P. Silva; B. Sarmento; J. Carvalho-Tavares; H. Bousbaa. "Co-inhibition of MPS-1 with BCL-2 family inhibitors enhances lung cancer cell killing in 2D and 3D culture systems". Paper presented in Trabalho apresentado em II TOXRUN International Congress, https://doi.org/10.48797/sl.2023.24, 2023.
  4. João P. N. Silva; L. Monteiro; Patrícia M.A. Silva; Bousbaa, Hassan. "Co-inhibition of mitotic kinesins and kinases with BCL-2 family inhibitors enhances cytotoxicity of oral cancer cells". Paper presented in Trabalho apresentado em II TOXRUN International Congress. https://doi.org/10.48797/sl.2023.25, 2023.
  5. João P. N. Silva; Silva, Patrícia; Hassan Bousbaa. "Potenciando o efeito terapêutico do inibidor da EG5 numa combinação com Navitoclax em células de cancro oral". Paper presented in 4º Encontro Nacional de Jovens Investigadores em Oncologia (ENJIO), 2022.
  6. Silva, Patrícia; Ana V. Nascimento; Olga Martinho; Rui M. Reis; Hassan Bousbaa. "INIBIÇÃO DA BUB3 + TRATAMENTO COM PACLITAXEL = UMA ESTRATÉGIA PROMISSORA PARA TRAVAR A PROLIFERAÇÃO CELULAR NO GLIOBLATOMA MULTIFORME". Paper presented in 4º Encontro Nacional de Jovens Investigadores em Oncologia (ENJIO), 2022.
  7. Marta Pereira; Patrícia M. A. Silva; Bousbaa, Hassan. "IMPROVING THE ANTITUMORAL ACTIVITY OF SECOND-GENERATION ANTIMITOTICS". Paper presented in I Congresso Internacional da TOXRUN – Unidade de Investigação em Toxicologia do IUCS, 2022.
  8. Bárbara Fernandes Pinto; Patrícia M.A. Silva; Juliana Carvalho-Tavares; Bousbaa, Hassan.. "A INIBIÇÃO DA MPS-1 COMBINADA COM UM INDUTOR DA APOPTOSE POTENCIALIZA A ATIVIDADE ANTITUMORAL EM CULTURAS 2D E 3D DE CÉLULAS DE CANCRO DO PULMÃO". Paper presented in I Congresso Internacional da TOXRUN – Unidade de Investigação em Toxicologia do IUCS, 2022.
  9. Delgado, Leonor; Monteiro, Luís; Patrícia M. A. Silva; Bousbaa, Hassan; Fernanda Garcez; Brilhante-Simões, Paula; Prada,. "BUBR1 AS A PROGNOSTIC BIOMARKER IN CANINE ORAL SQUAMOUS CELL CARCINOMA". Paper presented in 1º INTERNATIONAL CONGRESS OF UNIPRO RESEARCH UNIT (IUCS - CESPU), 2022.
  10. Pinto, Bárbara Fernandes; Silva, Patrícia M. A.; Juliana Carvalho-Tavares; Bousbaa, Hassan. "O Navitoclax potencializa os efeitos terapêuticos do inibidor da PLK-1 em culturas 2D e 3D de células de cancro de pulmão". Paper presented in 4º ENCONTRO NACIONAL DE JOVENS INVESTIGADORES EM ONCOLOGIA (ENJIO), 2022.
  11. Durães, Fernando; Novais, Pedro; Silva, Patrícia M. A.; Esteves, Cátia I. C.; Guieu, Samuel; Bousbaa, Hassan; Pinto, Madalena; Sousa, Emília. "Antitumor activity and fluorescence of tetracyclic thioxanthenes: new theranostic agents?". Paper presented in 26th EFMC International Symposium in Medicinal Chemistry, 2021.
  12. Silva, Patrícia. "Antitumor activity and fluorescence of tetracyclic thioxanthenes: new therasnostics agents?". Paper presented in EFMC-ISMC, International Symposium on Medicinal Chemistry, 2021.
  13. Silva, Patrícia. "Synthesis of enantiomeric pure chiral derivatives of 4'-methylchrysoeriol.". Paper presented in IJUP 2020 - Encontro de Investigação Jovem da Univerisdade do Porto, 2020.
  14. Silva, Patrícia. "Xanthone derivatives as inhibitors of P-glycoprotein and of tumor cell growth: synthesis and biological evaluation.". Paper presented in 13th National Organic Chemistry Meeting (13ENQO) and the 6th National Medicinal Chemistry Meeting (6ENQT), 2020.
  15. Silva, Patrícia. "New chalcone derivatives with suitable drug-like lipophilicity targeting mitosis.". Paper presented in 5th International Electronic Conference on Medicinal Chemistry, 2019.
  16. Silva, Patrícia. "A inibição da molécula p31(comet) sensibiliza células de cancro de pulmão de não-pequenas células ao tratamento com paclitaxel.". Paper presented in Encontro Nacional de Jovens Investigadores em Oncologia, 2019.
  17. Silva, Patrícia. "Targeting p31(comet) sensitizes non-small cell lung cancer cells to paclitaxel treatment". Paper presented in GenomePT Symposium, 2019.
  18. Silva, Patrícia. "Carboxyxanthone derivatives: synthesis and effect on human tumor cell lines". Paper presented in 2th National Organic Chemistry Meeting & 5th National Medicinal Chemistry Meeting, 2018.
  19. Silva, Patrícia. "New chalcone derivatives: synthesis and antitumor activity evaluation.". Paper presented in 12th National Organic Chemistry Meeting & 5th National Medicinal Chemistry Meeting, 2018.
  20. Silva, Patrícia. "Flavonoids targeting caspases: synthesis and antitumor activity evaluation". Paper presented in Trabalho apresentado em Italian-Spanish_Portuguese Joint Meeting in Medicinal Chemistry, MedChem, 17-20 July, Sicily 2018, Palermo, Italy., 2018.
  21. Silva, Patrícia. "2’,4’-Dihydroxy-3,4,5-Trimethoxychalcone Analogues: Synthesis, Biological Activity and Docking Studies". Paper presented in 12th YES (Young European Scientist) Meeting, 2017.
  22. Silva, Patrícia. "Synthesis, enantiomeric purity evaluation and enantioselectivity study on human tumor cell lines of new chiral derivatives of xanthones". Paper presented in 7th edition of the EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC-ASMC’17), 2017.
  23. Silva, Patrícia. "Spindly Expression in Oral Squamous Cell Carcinomas.". Paper presented in 6th World Oral Cancer Congress of the International Academy of Oral Oncology (IAOO), 2017.
  24. Silva, Patrícia. "BubR1 as a potential biomarker of malignant transformation in oral leukoplakias". Paper presented in 6th World Oral Cancer Congress of the International Academy of Oral Oncology (IAOO), 2017.
  25. Silva, Patrícia. "Heterocyclic Chalcone Derivatives: Synthesis, Antitumor Activity and Docking studies". Paper presented in IJUP 2017, 10º Encontro de Investigação Jovem da Universidade do Porto, 2017.
  26. Silva, Patrícia. "New Prenylated Chalcone Acting as an Antimitotic Agent and Inducing Mitotic Catastrophe in Human Breast Adenocarcinoma MCF-7 Cell Line". Paper presented in 2nd ASPIC (Associação Portuguesa de Investigação em Cancro) International Congress, 2016.
  27. Silva, Patrícia. "Targeting Spindly as Antimitotic Strategy to Induce Cancer Cell Death". Paper presented in 2nd ASPIC (Associação Portuguesa de Investigação em Cancro) International Congress, 2016.
  28. Silva, Patrícia. "Acetylated flavonoids and xanthones: synthesis and screening for antitumor activity". Paper presented in II Encontro Nacional de Estudantes de Química, 2015.
  29. Silva, Patrícia. "A new prenylated chalcone with anti-mitotic activity in cancer cell lines". Paper presented in XX Encontro Luso-Galego de Química, 2014.
  30. Silva, Patrícia. "Assessing the anti-mitotic activity of a new prenylated chalcone in cancer cell lines". Paper presented in INCOMAM'14 - International Conference on Microscopy and Microanalysis, XLVIII Congress of the Portuguese Microscopy Society, 2014.
  31. Silva, Patrícia. "Evaluating the prognostic value of BubR1 and Mad2 mitotic checkpoint protein expression in oral squamous cell carcinoma". Paper presented in INCOMAM'14 - International Conference on Microscopy and Microanalysis, XLVIII Congress of the Portuguese Microscopy Society, 2014.
  32. Silva, Patrícia. "Functional relationship between the mitotic checkpoint protein Bub3 and the molecular motor dynein in regulating kinetochore-micrtubule attachment". Paper presented in EMBO Conference Series, 3rd Edition, Microtubules: structure, Regulation and Function, 2014.
  33. Silva, Patrícia. "Are Bub3 and Dynein in a relationship? Functional relationship between the mitotic checkpoint protein Bub3 and the molecular motor dynein in regulating kinetochore-microtubule attachment". Paper presented in Embo Young Scientists´Forum, 2013.
  34. Silva, Patrícia; Moura, I.M.B.; Delgado, M.L.; Silva, P.M.A.; Lopes, C.A.; do Amaral, J.B.; Monteiro, L.S.; Bousbaa, H.. "High CDC20 expression is associated with poor prognosis in oral squamous cell carcinoma". Paper presented in XXII Porto Cancer Meeting & III Porto-Bordeaux Joint Meeting, 2013.
    10.1111/jop.12115
Encyclopedia entry
  1. Andrea Cunha , Patrícia M. A. Silva , Bruno Sarmento , Odília Queirós. "Targeting Glucose Metabolism to Overcoming Drug Resistance". In Scholarly Community Encyclopedia, MDPI, 2024. https://encyclopedia.pub/entry/54250.
    Published
  2. João P. N. Silva; Bárbara F. Pinto; Luís Monteiro; Patrícia M. A. Silva; Bousbaa, Hassan. Autor correspondente: Patrícia. "Combination Therapy to Fight Oral Cancer". In Scholarly Community Encyclopedia, MDPI, 2023. https://encyclopedia.pub/entry/45284..
    Published
  3. Silva, Patrícia M. A.; Bousbaa, Hassan. "The Role of BUB3 in Human Cancers". In In Scholarly Community Encyclopedia. MDPI, 2022. https://encyclopedia.pub/entry/23283.
    Published
  4. Bárbara Pinto; Ana C. Henriques; Silva, Patrícia; Bousbaa, Hassan. "Three-Dimensional Spheroids in Cancer Research". , 2020. https://encyclopedia.pub/entry/3418.
    Published
Journal article
  1. Calheiros-Lobo, Mafalda; Silva, João P. N.; Pinto, Bárbara; Monteiro, Luís; Silva, Patrícia M. A.; Bousbaa, Hassan. "Exploring the Therapeutic Implications of Co-Targeting the EGFR and Spindle Assembly Checkpoint Pathways in Oral Cancer". Pharmaceutics 16 9 (2024): 1196. http://dx.doi.org/10.3390/pharmaceutics16091196.
    10.3390/pharmaceutics16091196
  2. Henriques, Ana C.; Silva, João P. N.; Pinto, Bárbara; Silva, Patrícia M. A.; Bousbaa, Hassan. Corresponding author: Bousbaa, Hassan. "Exploring the Clinical Relevance of p31comet in Head and Neck Squamous Cell Carcinoma through UALCAN database analysis". Scientific Letters (2024): https://publicacoes.cespu.pt/index.php/sl/article/view/266.
    Published
  3. Silva, João P. N.; Pinto, Bárbara; Monteiro, Luís; Silva, Patrícia M. A.; Bousbaa, Hassan. "Coupling Kinesin Spindle Protein and Aurora B Inhibition with Apoptosis Induction Enhances Oral Cancer Cell Killing". Cancers 16 11 (2024): 2014. http://dx.doi.org/10.3390/cancers16112014.
    Published • 10.3390/cancers16112014
  4. Barbosa, Flávia; Araújo, Joana; Gonçalves, Virgínia M. F.; Palmeira, Andreia; Cunha, Andrea; Silva, Patrícia M. A.; Fernandes, Carla; et al. "Evaluation of Antitumor Activity of Xanthones Conjugated with Amino Acids". International Journal of Molecular Sciences 25 4 (2024): 2121. http://dx.doi.org/10.3390/ijms25042121.
    Published • 10.3390/ijms25042121
  5. Moreira, Joana; Silva, Patrícia M. A.; Castro, Eliseba; Saraiva, Lucília; Pinto, Madalena; Bousbaa, Hassan; Cidade, Honorina. "BP-M345 as a Basis for the Discovery of New Diarylpentanoids with Promising Antimitotic Activity". International Journal of Molecular Sciences 25 3 (2024): 1691. http://dx.doi.org/10.3390/ijms25031691.
    Published • 10.3390/ijms25031691
  6. Silva, Patrícia M. A.; Henriques, Ana C.; Silva, João Pedro Nunes; Pinto, Bárbara; Bousbaa, Hassan. Corresponding author: Bousbaa, Hassan. "Targeting p31comet to Enhance Cisplatin-induced Cytotoxicity in Oral Squamous Cell Carcinoma Cells". Scientific Letters (2024):
    Published
  7. Pinto, Bárbara; Silva, João P. N.; Silva, Patrícia M. A.; Barbosa, Daniel José; Sarmento, Bruno; Tavares, Juliana Carvalho; Bousbaa, Hassan. "Maximizing Anticancer Response with MPS1 and CENPE Inhibition Alongside Apoptosis Induction". Pharmaceutics 16 1 (2023): 56. http://dx.doi.org/10.3390/pharmaceutics16010056.
    10.3390/pharmaceutics16010056
  8. Cunha, Andrea; Silva, Patrícia; Ana Catarina Rocha; Queiros, Odilia. "Unravelling the Warburg effect: glycolytic inhibitors as promising agents in cancer therapy". Scientific Letters 1 1 (2023): https://publicacoes.cespu.pt/index.php/sl/article/view/116.
    Open access • Published
  9. Cunha, Andrea; Silva, Patrícia M. A.; Sarmento, Bruno; Queirós, Odília. "Targeting Glucose Metabolism in Cancer Cells as an Approach to Overcoming Drug Resistance". Pharmaceutics 15 11 (2023): 2610. http://dx.doi.org/10.3390/pharmaceutics15112610.
    10.3390/pharmaceutics15112610
  10. João Silva; Bárbara Pinto; Luis Monteiro; Patrícia Silva; Hassan Bousbaa. "Combination Therapy as a Promising Way to Fight Oral Cancer". Pharmaceutics (2023): https://www.mdpi.com/1999-4923/15/6/1653.
    10.3390/pharmaceutics15061653
  11. Joana Moreira; Patrícia Silva; Matilde Barros; Lucília Saraiva; Madalena M. M. Pinto; Hassan Bousbaa; Honorina Cidade. "Discovery of a New Chalcone-Trimethoxycinnamide Hybrid with Antimitotic Effect: Design, Synthesis, and Structure—Activity Relationship Studies". Pharmaceuticals (2023): https://www.mdpi.com/1424-8247/16/6/879.
    10.3390/ph16060879
  12. Maria Leonor Delgado; Luis Monteiro; Patrícia Silva; Hassan Bousbaa; Fernanda Garcez; João Silva; Paula Brilhante-Simões; Isabel Pires; Justina Prada. "BUBR1 as a Prognostic Biomarker in Canine Oral Squamous Cell Carcinoma". Animals (2022): https://www.mdpi.com/2076-2615/12/22/3082.
    10.3390/ani12223082
  13. Andrea Cunha; Ana Catarina Rocha; Flávia Barbosa; Ana Baião; Patrícia Silva; Bruno Sarmento; Odilia Queiros. "Glycolytic Inhibitors Potentiated the Activity of Paclitaxel and Their Nanoencapsulation Increased Their Delivery in a Lung Cancer Model". Pharmaceutics (2022): https://www.mdpi.com/1999-4923/14/10/2021.
    10.3390/pharmaceutics14102021
  14. Pinto, Bárbara; Novais, Pedro; Henriques, Ana C.; Carvalho-Tavares, Juliana; Silva, Patrícia M. A.; Bousbaa, Hassan. "Navitoclax Enhances the Therapeutic Effects of PLK1 Targeting on Lung Cancer Cells in 2D and 3D Culture Systems". Pharmaceutics 14 6 (2022): 1209. http://dx.doi.org/10.3390/pharmaceutics14061209.
    10.3390/pharmaceutics14061209
  15. Silva, Patrícia M. A.; Bousbaa, Hassan. "BUB3, beyond the Simple Role of Partner". Pharmaceutics 14 5 (2022): 1084. http://dx.doi.org/10.3390/pharmaceutics14051084.
    10.3390/pharmaceutics14051084
  16. Bárbara Pinto; Catarina Pacheco; Silva, Patrícia M. A.; Juliana Carvalho-Tavares; Bruno Sarmento; Hassan Bousbaa. "Nanomedicine internalization and penetration: why should we use spheroids?". Scientific Letters (2022):
    Open access • Published
  17. Silva, Patrícia M. A.; Ana V. Nascimento; Olga Martinho; Rui M. Reis; Hassan Bousbaa. "Targeting BUB3 in combination with paclitaxel inhibits proliferation of glioblastoma cells by enhancing cellular senescence". Scientific Letters (2022): https://publicacoes.cespu.pt/index.php/sl/article/view/11.
    Published
  18. Pedro Novais; Patrícia Silva; Joana Moreira; Andreia Palmeira; Isabel Amorim; Madalena M. M. Pinto; Honorina Cidade; Hassan Bousbaa. "BP-M345, a New Diarylpentanoid with Promising Antimitotic Activity". Molecules (2021): https://www.mdpi.com/1420-3049/26/23/7139.
    10.3390/molecules26237139
  19. Nunes, Mariana; Silva, Patrícia M. A.; Coelho, Ricardo; Pinto, Carla; Resende, Albina; Bousbaa, Hassan; Almeida, Gabriela M.; Ricardo, Sara. "Generation of Two Paclitaxel-Resistant High-Grade Serous Carcinoma Cell Lines With Increased Expression of P-Glycoprotein". Frontiers in Oncology 11 (2021): http://dx.doi.org/10.3389/fonc.2021.752127.
    10.3389/fonc.2021.752127
  20. Pedro Novais; Patrícia Silva; Isabel Amorim; Hassan Bousbaa. "Second-Generation Antimitotics in Cancer Clinical Trials". Pharmaceutics (2021): https://www.mdpi.com/1999-4923/13/7/1011.
    10.3390/pharmaceutics13071011
  21. Fernando Durães; Patrícia Silva; Pedro Novais; Isabel Amorim; Luis Gales; Cátia I. C. Esteves; samuel guieu; et al. "Tetracyclic Thioxanthene Derivatives: Studies on Fluorescence and Antitumor Activity". Molecules (2021): https://www.mdpi.com/1420-3049/26/11/3315.
    10.3390/molecules26113315
  22. Henriques AC; Silva PMA; Sarmento B; Bousbaa H. "Antagonizing the spindle assembly checkpoint silencing enhances paclitaxel and Navitoclax-mediated apoptosis with distinct mechanistic.". Scientific reports (2021): http://europepmc.org/abstract/med/33603057.
    10.1038/s41598-021-83743-7
  23. Henriques AC; Silva PMA; Sarmento B; Bousbaa H. "The Mad2-Binding Protein p31comet as a potential target for human cancer therapy.". Current cancer drug targets (2021): http://europepmc.org/abstract/med/33511944.
    10.2174/1568009621666210129095726
  24. Monteiro, L.; Silva, P.; Delgado, L.; Amaral, B.; Garcês, F.; Salazar, F.; Pacheco, JJ.; et al. "Expression of spindle assembly checkpoint proteins BubR1 and Mad2 expression as potential biomarkers of malignant transformation of oral leukoplakia: an observational cohort study". Medicina Oral Patología Oral y Cirugia Bucal (2021): e719-e728. http://dx.doi.org/10.4317/medoral.24511.
    10.4317/medoral.24511
  25. Fábio França; Patrícia Silva; José X. Soares; Ana C. Henriques; Daniela R. P. Loureiro; Carlos M. G. Azevedo; Carlos Afonso; Hassan Bousbaa. "A Pyranoxanthone as a Potent Antimitotic and Sensitizer of Cancer Cells to Low Doses of Paclitaxel". Molecules (2020): https://www.mdpi.com/1420-3049/25/24/5845.
    10.3390/molecules25245845
  26. Pinto B; Henriques AC; Silva PMA; Bousbaa H. "Three-Dimensional Spheroids as In Vitro Preclinical Models for Cancer Research.". Pharmaceutics (2020): http://europepmc.org/abstract/med/33291351.
    10.3390/pharmaceutics12121186
  27. Carraro, Maria L.; Marques, Sandra; Silva, Ana Sofia; Freitas, Bruno; Silva, Patrícia M. A.; Pedrosa, Joel; De Marco, Paolo; et al. "Synthesis of New Chiral Derivatives of Xanthones with Enantioselective Effect on Tumor Cell Growth and DNA Crosslinking". ChemistrySelect 5 33 (2020): 10285-10291. http://dx.doi.org/10.1002/slct.202002588.
    10.1002/slct.202002588
  28. Pinto, Patricia; Machado, Carmen Mariana; Moreira, Joana; Almeida, José Diogo P.; Silva, Patrícia M.A.; Henriques, Ana C.; Soares, José X.; et al. "Chalcone derivatives targeting mitosis: synthesis, evaluation of antitumor activity and lipophilicity". European Journal of Medicinal Chemistry 184 (2019): 111752. http://dx.doi.org/10.1016/j.ejmech.2019.111752.
    Published • 10.1016/j.ejmech.2019.111752
  29. Silva, Patrícia M. A.; Delgado, Maria Leonor; Ribeiro, Nilza; Florindo, Cláudia; Tavares, Álvaro A.; Ribeiro, Diana; Lopes, Carlos; et al. "Spindly and Bub3 expression in oral cancer: Prognostic and therapeutic implications". Oral Diseases 25 5 (2019): 1291-1301. http://dx.doi.org/10.1111/odi.13089.
    Published • 10.1111/odi.13089
  30. Alves, Ana; Correia-da-Silva, Marta; Nunes, Claúdia; Campos, João; Sousa, Emília; Silva, Patrícia; Bousbaa, Hassan; et al. "Discovery of a New Xanthone against Glioma: Synthesis and Development of (Pro)liposome Formulations". Molecules 24 3 (2019): 409. http://dx.doi.org/10.3390/molecules24030409.
    Published • 10.3390/molecules24030409
  31. Henriques, Ana C.; Ribeiro, Diana; Pedrosa, Joel; Sarmento, Bruno; Silva, Patrícia M.A.; Bousbaa, Hassan. "Mitosis inhibitors in anticancer therapy: When blocking the exit becomes a solution". Cancer Letters 440-441 (2019): 64-81. http://dx.doi.org/10.1016/j.canlet.2018.10.005.
    Published • 10.1016/j.canlet.2018.10.005
  32. Joana Moreira; Diana Ribeiro; Patrícia Silva; Nair Nazareth; Madalena N Monteiro; Andreia Palmeira; Lucília Saraiva; et al. "New Alkoxy Flavone Derivatives Targeting Caspases: Synthesis and Antitumor Activity Evaluation". Molecules (2018): http://www.mdpi.com/1420-3049/24/1/129.
    10.3390/molecules24010129
  33. Silva, Patrícia. "Synthesis of New Glycosylated Flavonoids with Inhibitory Activity on Cell Growth". Molecules (2018): http://www.mdpi.com/1420-3049/23/5/1093.
    10.3390/molecules23051093
  34. Silva, P.M.A.; Ribeiro, N.; Lima, R.T.; Andrade, C.; Diogo, V.; Teixeira, J.; Florindo, C.; et al. "Suppression of spindly delays mitotic exit and exacerbates cell death response of cancer cells treated with low doses of paclitaxel". Cancer Letters 394 (2017): 33-42. http://www.scopus.com/inward/record.url?eid=2-s2.0-85014640901&partnerID=MN8TOARS.
    10.1016/j.canlet.2017.02.024
  35. Diogo, V.; Teixeira, J.; Silva, P.M.A.; Bousbaa, H.. "Spindle Assembly Checkpoint as a Potential Target in Colorectal Cancer: Current Status and Future Perspectives". Clinical Colorectal Cancer 16 1 (2017): 1-8. http://www.scopus.com/inward/record.url?eid=2-s2.0-84995570267&partnerID=MN8TOARS.
    10.1016/j.clcc.2016.06.006
  36. Fonseca, J.; Marques, S.; Silva, P.M.A.; Brandão, P.; Cidade, H.; Pinto, M.M.; Bousbaa, H.. "Prenylated chalcone 2 acts as an antimitotic agent and enhances the chemosensitivity of tumor cells to paclitaxel". Molecules 21 8 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84980407559&partnerID=MN8TOARS.
    10.3390/molecules21080982
  37. Silva, P.M.A.; Tavares, Á.A.; Bousbaa, H.. "Co-silencing of human Bub3 and dynein highlights an antagonistic relationship in regulating kinetochore-microtubule attachments". FEBS Letters 589 23 (2015): 3588-3594. http://www.scopus.com/inward/record.url?eid=2-s2.0-84947079444&partnerID=MN8TOARS.
    10.1016/j.febslet.2015.10.017
  38. Teixeira, J.H.; Silva, P.M.A.; Faria, J.; Ferreira, I.; Duarte, P.; Delgado, M.L.; Queirós, O.; et al. "Clinicopathologic significance of BubR1 and Mad2 overexpression in oral cancer". Oral Diseases 21 6 (2015): 713-720. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938738610&partnerID=MN8TOARS.
    10.1111/odi.12335
  39. Marques, S.; Fonseca, J.; Silva, P.M.A.; Bousbaa, H.; Marques S; Fonseca J; Silva PM; Bousbaa H. "Targeting the spindle assembly checkpoint for breast cancer treatment". Current Cancer Drug Targets 15 4 (2015): 272-281. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930693970&partnerID=MN8TOARS.
    10.2174/1568009615666150302130010
  40. Teixeira, J.H.; Silva, P.M.; Reis, R.M.; Moura, I.M.; Marques, S.; Fonseca, J.; Monteiro, L.S.; Bousbaa, H.. "An overview of the spindle assembly checkpoint status in oral cancer". BioMed Research International 2014 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84903641337&partnerID=MN8TOARS.
    10.1155/2014/145289
  41. Silva, P.M.A.; Reis, R.M.; Bolanos-Garcia, V.M.; Florindo, C.; Tavares, Á.A.; Bousbaa, H.. "Dynein-dependent transport of spindle assembly checkpoint proteins off kinetochores toward spindle poles". FEBS Letters 588 17 (2014): 3265-3273. http://www.scopus.com/inward/record.url?eid=2-s2.0-84906258277&partnerID=MN8TOARS.
    10.1016/j.febslet.2014.07.011
  42. Barbosa, J.; Nascimento, A.V.; Faria, J.; Silva, P.; Bousbaa, H.. "The spindle assembly checkpoint: Perspectives in tumorigenesis and cancer therapy". Frontiers in Biology 6 2 (2011): 147-155. http://www.scopus.com/inward/record.url?eid=2-s2.0-80051713496&partnerID=MN8TOARS.
    10.1007/s11515-011-1122-x
  43. Silva, P.; Barbosa, J.; Nascimento, A.V.; Faria, J.; Reis, R.; Bousbaa, H.. "Monitoring the fidelity of mitotic chromosome segregation by the spindle assembly checkpoint". Cell Proliferation 44 5 (2011): 391-400. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053152679&partnerID=MN8TOARS.
    10.1111/j.1365-2184.2011.00767.x
Journal issue
  1. Silva, Patrícia M. A.; Cristina Pinto Ricardo Xavier. "Recent Trends in Experimental Models for Cancer Research". International Journal of Molecular Sciences (2024): https://www.mdpi.com/journal/ijms/special_issues/NCXFWT0656.
    Published • Invited editor
  2. Odilia Queiros; Silva, Patrícia. "Nano-Drug Delivery Systems for Targeting the Tumor Microenvironment and Simultaneously Overcoming Drug Resistance Properties". Pharmaceutics (2023): https://www.mdpi.com/journal/pharmaceutics/special_issues/BG11RU976G.
    Published • Invited editor
  3. Silva, Patrícia; Cidade, Honorina; Bousbaa, Hassan. "Special Issue "Bioactive Compounds in Cancers". International Journal of Molecular Sciences (2023): https://www.mdpi.com/journal/ijms/special_issues/2I2VLC08N0.
    Published • Invited editor
  4. Silva, Patrícia; Barbosa, Maria Joana; Barbosa, Daniel José; Elaine Fagundes. "Special Issue "The (Un)Desirability of Cell Death in Health and Disease: Emerging Modulators and their Mechanisms"". Frontiers in Cell and Developmental Biology (2023): https://www.frontiersin.org/research-topics/57035/the-undesirability-of-cell-death-in-health-and-disease-emerging-modulators-and-their-mechanisms.
    Published • Invited editor
Thesis / Dissertation
  1. Silva, Patrícia. "The Spindle Assembly Checkpoint: New Insights Into Its Function, Regulation and Therapeutic Implications". PhD, Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, 2017. http://hdl.handle.net/10400.1/10103.
  2. Silva, Patrícia. "Relação entre a proteína Bub3 do checkpoint mitótico e a proteína motora Dineína durante o alinhamento dos cromossomas na placa metafásica". Master, Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), 2011. https://repositorio.cespu.pt/handle/20.500.11816/317.
Website
  1. Gonçalves, Virgínia M. F.; Silva, Patrícia M. A.; Azevedo, Rui M.S.. III 1H-TOXRUN International Congress 2024. 2024. https://toxrun.iucs.cespu.pt/congress2024/.
  2. Silva, Patrícia M. A.; Gonçalves, Virgínia M. F. ; Azevedo, Rui M.S. II International Congress of UNIPRO Research UNIT (IUCS-CESPU). 2023. https://unipro.iucs.cespu.pt/congress2023/.
  3. Silva, Patrícia M. A.; Gonçalves, Virgínia M. F. ; Azevedo, Rui M.S. II TOXRUN International Congress 2023 (IUCS-CESPU). 2023. https://toxrun.iucs.cespu.pt/congress2023/.
  4. Bousbaa, Hassan; Gonçalves, Virgínia M. F; Silva, Patrícia M. A.; Barbosa, Maria Joana; Azevedo, Rui M.S. Scientific Journal - Scientific Letters - CESPU. 2022. https://publicacoes.cespu.pt/index.php/sl.
  5. Azevedo, R. M.S; Gonçalves, Virgínia M. F. ; Silva, Patrícia M. A.; Monteiro, Luís. UNIPRO - Oral Pathology and Rehabilitation Research Unit - Instituto Universitário de Ciências da Saúde. 2022. https://unipro.iucs.cespu.pt/.
  6. Azevedo, Rui M.S; Gonçalves, Virgínia M. F; Silva, Patrícia M. A.; Dinis-Oliveira, Ricardo Jorge. 1H- One Health Toxicology Research Unit (1H-TOXRUN) - Instituto Universitário de Ciências da Saúde. 2021. https://toxrun.iucs.cespu.pt/.

Other

Other output
  1. Antimitóticos de segunda geração (SGAs) em foco: uma segunda oportunidade para aumentar sua eficácia no tratamento do câncer de pulmão.. Research proposal submitted to CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil, for funding. Team member.. 2023. Silva, Patrícia.
  2. Contornando a resistência ao Paclitaxel no cancro do ovário. Proposal submitted to "PRÉMIO LIGA INOVAÇÃO 2022", Liga Portuguesa Contra o Cancro. 5000euros. Not funded. Principal Investigator.. 2022. Silva, Patrícia.
  3. 2022.06056.PTDC. Chiral Flavonoids: enantioselectivity and (bio)degradability as sustainable strategy to search for new potential anti-inflammatory and antitumor agents. Researcher. Proposal submitted to FCT for funding. Not funded. Team member. 2022. Silva, Patrícia.
  4. 2022.02247.PTDC. Os antimitóticos de segunda geração: nova esperança como agentes anticancerígenos?. Researcher. Proposal submitted to FCT for funding. Not funded. Co-Investigator.. 2022. Patrícia Siva.
  5. 2022.01567.PTDC. Creation of a drug test using ovarian cancer ascites-derived organoids. Researcher. Proposal submitted to FCT for funding. Not funded. Team member.. 2022. Silva, Patrícia M. A..
  6. 2022.05468.PTDC. Unravelling new analgesic drugs: the therapeutic potential of krokodil morphinans. Researcher. Proposal submitted to FCT for funding. Not funded. Team member.. 2022. Patrícia MA..
  7. PTDC/MED-ONC/3136/2021. The second-generation of antimitotics: a second chance?. Co-Principal Researcher. Proposal submitted to FCT for funding. Not funded. Co-Investigator. 2021. Silva, Patrícia M. A..
  8. PTDC/BIA-CEL/4442/2021. Control of Cell Proliferation.. Researcher. Proposal submitted to FCT for funding. Not funded. Team member.. 2021. Silva, Patrícia M. A..
  9. PTDC/QUI-QOR/2896/2021. Xanthones and flavonoids: chirality and (bio)degradability as sustainable strategy to search for new potential anti-inflammatory and antitumor agents.. Researcher. Proposal submitted to FCT for funding. Not funded. Team member.. 2021. Silva, Patrícia M. A..
  10. PTDC/QUI-QOR/2731/2021. 2D-Lipid tags as biomolecular tools for breast cancer detection. Researcher. Proposal submitted to FCT for funding. Not funded. 2021.
  11. PTDC/MED-ONC/1360/2020. Three-Dimensional Models of Cancer to Increase the Predictive Value of Preclinical Evaluation of Antimitotic Agents.. Researcher. Proposal submitted to FCT for funding. Not funded. 2020.
  12. PTDC/CTA-OHR/3912/2020. Natural products as antitumor agents: bioprospecting, synthesis and nanotechnological approaches to improve antitumor activity.. Researcher. Proposal submitted to FCT for funding. Not funded. 2020.
  13. PTDC /QUI-QOR/5732/2020. Chiral derivatives of xanthones and flavonoids: an integrative strategy to discovery new drug candidates.. Researcher. Proposal submitted to FCT for funding. Not funded. 2020.
  14. C492597698-00087532. Therapeutic targeting of cell division through nanoparticle-mediated siRNA delivery for the treatment of oral cancer.. Researcher. Proposal submitted to FCT for funding. Not funded. 2017.
  15. PTDC/BIM-ONC/0195/2014. NanoAntiMito: Therapeutic targeting of cell division through functionalized nanoparticle-mediated siRNA delivery for the treatment of lung cancer. Researcher. Proposal submitted to FCT for funding. Not funded. 2014.
  16. PTDC/BEX-BCM/0322/2012. Functional Relationship Between the Human Motor Protein Dynein and the Spindle Assembly Checkpoint Proteins in Chromosome Alignment During Mitosis. Researcher. Proposal submitted to FCT for funding. Not funded. 2012.
  17. PTDC/BIA-BCM/122717/2010. Functional Relationship Between the Human Motor Protein Dynein and the Spindle Assembly Checkpoint Proteins in Chromosome Alignment During Mitosis. Proposal submitted to FCT for funding. Not funded. 2010.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/11/30 The Role of the Pharmacist in Oncological Research (Invited speaker) XIV Workshop de Prática de Farmácia. IUCS-CESPU
(Portugal)
2023/06/02 Promoting oral cancer cell death by combining an apoptosis inducer with an antimitotic II International Congress of UNIPRO Oral Pathology and Rehabilitation Research Unit
(Penafiel, Portugal)
2022/04/08 Targeting BUB3 in combination with paclitaxel inhibits proliferation of glioblastoma cells by enhancing cellular senescence Congress 2022 APCF-TOXRUN
TOXRUN (Porto)
2021/11/27 Explorando a atividade antitumoral do composto BP-M345. 4ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia (4ª rRACS)
RACS (Benguela, Angola)
2021/11/26 Análise do potencial antitumoral da combinação de um inibidor de MPS-1 e um indutor de apoptose em culturas 2D e 3D de cancro do pulmão 4ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia (4ª rRACS)
RACS (Benguela, Angola)
2021/11/26 Expressão e potencial terapêutico da proteína MPS-1 no cancro oral 4ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia (4ª rRACS)
RACS (Benguela, Angola)
2021/11/26 Inibição da Bub3: uma estratégia promissora na potenciação do efeito antitumoral do paclitaxel 4ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia (4ª rRACS)
RACS (Benguela, Angola)
2021/11/25 Interferindo com a proteína p31comet aumenta a citotoxicidade do Paclitaxel e do Navitoclax em esferóides do cancro do pulmão 4ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia (4ª rRACS)
RACS (Benguela, Angola)
2020 Potenciação da morte celular induzida pelo Navitoclax em combinação com antimitóticos 3ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia – 3ª rRACS
(Braga, Portugal)
2020 A inibição da proteína p31comet sensibiliza as células de cancro de pulmão de não-pequenas células ao tratamento com paclitaxel 3ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia – 3ª rRACS
(Braga, Portugal)
2020 Investigando a atividade antitumoral do composto XJS2 e seu mecanismo de ação 3ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia – 3ª rRACS
(Braga, Portugal)
2020 Avaliação da atividade antitumoral de derivados xantónicos 3ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia – 3ª rRACS
(Braga, Portugal)
2019/11/20 New chalcone derivatives with antimitotic activity: synthesis, antitumor activity evaluation and chemosensitivity studies. XXV Encontro Galego-Portugues de Química
COLQUIGA & SPQ (Santiago de Compostela, Spain)
2019/05/17 Discovery of a New Xanthone against Glioma: Synthesis and Development of (Pro)liposome Formulations 4th Meeting on Medicinal Biotechnology
Escola Superior de Saúde do Porto (Porto, Portugal)
2018/09/07 Antitumor Chalcone Derivatives: Synthesis and Biological Activity Evaluation. IJUP 2018, 11º Encontro de Investigação Jovem da Universidade do Porto
University of Porto (Porto, Portugal)
2018/03/07 Chalcone Derivatives with Potential Antitumor Activity: Synthesis and Antimitotic Activity Evaluation. National Organic Chemistry Meeting & 5th National Medicinal Chemistry Meeting
Faculty of Pharmacy of the University of Porto (Porto, Portugal)
2017/09/14 2’,4’-Dihydroxy-3,4,5-Trimethoxychalcone Analogues: Synthesis, Biological Activity and Docking Studies. 12th YES (Young European Scientist) Meeting
Faculty of Medicine of the University of Porto (Porto, Portugal)
2017/02/08 Heterocyclic Chalcone Derivatives: Synthesis, Antitumor Activity and Docking studies. IJUP 2017, 10º Encontro de Investigação Jovem da Universidade do Porto
University of Porto (Porto, Portugal)
2016/12/15 Dissecting the role of spindle assembly checkpoint components in regulating chromosome attachment to the mitotic spindle: a functional and proteomic-based analysis Jornadas dos Doutorandos em Ciências Biomédicas
Universidade do Algarve (Faro, Portugal)
2016/10/28 A mitose como alvo terapêutico contra o cancro I Congresso Nacional de Ciências Biomédicas Laboratoriais
Instituto Politécnico de Bragança (Bragança, Portugal)
2015/12/14 Dissecting the role of spindle assembly checkpoint components in regulating chromosome attachment to the mitotic spindle: a functional and proteomic-based analysis Jornadas dos Doutorandos em Ciências Biomédicas
Universidade do Algarve (Faro, Portugal)
2015/05/13 Evaluation of the antimitotic activity of a new prenylated chalcone in NCI-H460 non-small cell lung cancer cells IJUP 2015, 8º Encontro de Investigação Jovem da Universidade do Porto
University of Porto (Porto, Portugal)
2015/05/13 Therapeutic targeting of the mitotic checkpoint to increase sensitivity of glioblastoma cells to anti-mitotic agents IJUP 2015, 8º Encontro de Investigação Jovem da Universidade do Porto
University of Porto (Porto, Portugal)
2015/05/13 Targeting Cdc20 protein to increase sensitivity of colorectal cancer cells to paclitaxel IJUP 2015, 8º Encontro de Investigação Jovem da Universidade do Porto
University of Porto (Porto, Portugal)
2015/05/13 A new prenylated chalcone induces mitotic arrest and cell death by mitotic catastrophe in MCF-7 breast cancer cell line IJUP 2015, 8º Encontro de Investigação Jovem da Universidade do Porto
University of Porto (Porto, Portugal)
2014/12/15 Dissecting the role of spindle assembly checkpoint components in regulating chromosome attachment to the mitotic spindle: a functional and proteomic-based analysis Jornadas dos Doutorandos em Ciências Biomédicas
Universidade do Algarve (Faro, Portugal)
2014/11/06 Tracking dynein-mediated transport of spindle assembly checkpoint proteins from kinetochore to spindle pole INCOMAM'14 - International Conference on Microscopy and Microanalysis, XLVIII Congress of the Portuguese Microscopy Society
Faculty of Engineering of the University of Porto (Porto, Portugal)
2013/12/17 Dissecting the role of spindle assembly checkpoint components in regulating chromosome attachment to the mitotic spindle: a functional and proteomic-based analysis Jornadas dos Doutorandos em Ciências Biomédicas
Universidade do Algarve (Faro, Portugal)
2012/03/07 Relationship between mitotic checkpoint proteins and aneuploidy II Pathological Anatomy Symposium
IPSN-CESPU (Gandra, Portugal)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2023/09 - Current Targeting Eg5 and BCL-2 to overcome paclitaxel resistance in ovarian cancer.
Co-supervisor of Carina Isabel Ribeiro Gomes
Biomedical Sciences (Degree)
Instituto Universitário de Ciências da Saúde, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2023/09 - Current Targeting Mps1 and BCL-XL/BCL-2 to overcome paclitaxel resistance in ovarian cancer.
Co-supervisor of Francisca Nazaré de Mesquita Sampaio
Biomedical Sciences (Degree)
Instituto Universitário de Ciências da Saúde, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2023/09 - Current Mitotic proteins KSP and Aurora B: potential biomarkers and treatment targets for oral cancer
Co-supervisor of Raquel Maria Sousa Silva
Biomedical Sciences (Degree)
Instituto Universitário de Ciências da Saúde, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2023 - Current Curcumine and oral cancer (Preliminary)
Co-supervisor of Mathilde Rouffineau
Medicina Dentária (Integrated Master) (Master)
Instituto Universitário de Ciências da Saúde, Portugal
2021/02/01 - Current The Second-generation of antimitotics: mechanistic insights into the anticancer activity and therapeutic potential
Co-supervisor of João Pedro Nunes Silva
Ciências Biomédicas (PhD)
Instituto Universitário de Ciências da Saúde, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2020/02 - Current 3D tumor spheroids as preclinical models to study oral Cancer
Co-supervisor of Mafalda Maria Calheiros Lobo Duarte Pinto Guimarães
Ciências Biomédicas (PhD)
Instituto Universitário de Ciências da Saúde, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2022/10 - 2023/07/11 Characterization of the cytotoxicity mechanism of new molecules with antitumor potential
Co-supervisor of Eliseba Lima Martins Castro
Ciências Biomédicas (Degree)
Instituto Universitário de Ciências da Saúde, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2021/09 - 2022/07 Improving the antitumoral activity of second-geneation antimitotics
Co-supervisor
Ciências Biomédicas (Degree)
Instituto Universitário de Ciências da Saúde, Portugal
2021/09 - 2022/07 Improving the antitumoral activity pf second-geneation antimitotics.
Co-supervisor
Ciências Biomédicas (Degree)
Instituto Universitário de Ciências da Saúde, Portugal
2019 - 2020/12/18 Investigating the antitumoral activity and mechanism action of the a xanthone derivative
Co-supervisor of Fábio França Vieira e Silva
Oncobiologia - Mecanismos Moleculares do Cancro (Master)
Universidade do Algarve, Portugal
2019 - 2020 Evaluation of antitumor activity of a small molecule
Co-supervisor
Ciências Biomédicas (Degree)
Instituto Universitário de Ciências da Saúde, Portugal
2019 - 2020 Evaluation of antitumor activity of a small molecule
Co-supervisor
Ciências Biomédicas (Degree)
Instituto Universitário de Ciências da Saúde, Portugal
2018 - 2018 Avaliação da atividade antitumoral de pequenas moléculas naturais e sintéticas
Co-supervisor
Ciências Biomédicas (Scientific initiation)
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2018 - 2018 Avaliação da atividade antitumoral de pequenas moléculas de origem natural e sintética
Co-supervisor
Ciências Biomédicas (Degree)
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2017 - 2017 Antitumor Chalcone Derivatives: synthesis and biological activity evaluation
Co-supervisor
Química Farmacêutica (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2017 - 2017 Evaluation of the antitumoral activity of small molecules with natural and synthetic origin
Co-supervisor
Bioquímica (Degree)
Instituto Universitário de Ciências da Saúde, Portugal
2016 - 2017 Avaliação da atividade antiproliferativa de uma pequena molécula em linhas celulares do cancro da mama
Co-supervisor
Bioquímica (Degree)
Instituto Universitário de Ciências da Saúde, Portugal
2015 - 2015 Screening for small molecules with potential antitumour activity and characterization of the antimitotic activity of a prenylated chalcone in NCI-H460 non- small cell lung cancer cells
Co-supervisor
Terapias Moleculares (Master)
Instituto Universitário de Ciências da Saúde, Portugal
2015 - 2015 Screening and identification of small molecules with potential antitumour activity and insight into the mechanism of action of a prenylated chalcone in MCF-7 breast cancer cells
Co-supervisor
Terapias Moleculares (Master)
Instituto Universitário de Ciências da Saúde, Portugal
2015 - 2015 Evaluation of the antiproliferative activity of a small molecule in human cancer cell lines
Co-supervisor
Biologia Aplicada (Degree)
Universidade do Minho, Portugal
2015 - 2015 Avaliação da atividade antiproliferativa de uma pequena molécula em linhas celulares do cancro da mama
Co-supervisor
Medicina (Other)
Universidade do Algarve, Portugal
2014 - 2015 Checkpoint mitótico como alvo terapêutico para sensibilizar células cancerígenas a agentes antimitóticos
Co-supervisor
Oncobiologia - Mecanismos Moleculares do Cancro (Master)
Universidade do Algarve, Portugal
2014 - 2015 Interferindo com o "checkpoint" mitótico para potenciar a ação de agentes anti-mitóticos
Co-supervisor
Oncobiologia - Mecanismos Moleculares do Cancro (Master)
Universidade do Algarve, Portugal
2014 - 2014 Silenciamento do Checkpoint Mitótico: Transporte da proteína Mad2 dos cinetocoros para os pólos do fuso mitótico, via Dineína Citoplasmática em Células HeLa
Co-supervisor
Medicina (Other)
Universidade do Algarve, Portugal
2013 - 2013 Depleção da proteína Mad2 por RNAi em células HeLa
Co-supervisor
Medicina (Other)
Universidade do Algarve, Portugal
2013 - 2013 Depleção da proteína Mad2 por RNAi em células HeLa
Co-supervisor
Medicina (Other)
Universidade do Algarve, Portugal

Event organisation

Event name
Type of event (Role)
Institution / Organization
2024/05/02 - 2024/05/03 III 1H-TOXRUN International Congress 2024 | Porto - Portugal (2024 - 2024)
Congress (Other)
Instituto Universitário de Ciências da Saúde Unidade de Investigação em Toxicologia, Portugal
2023/06/01 - 2023/06/02 II International Congress of UNIPRO Research Unit 2023 | Penafiel, Portugal (2023/06/01 - 2023/06/02)
Congress (Member of the Organising Committee)
Instituto Universitário de Ciências da Saúde, Portugal
2023/04/27 - 2023/04/28 II TOXRUN International Congress 2023 | Porto - Portugal (2023 - 2023)
Congress (Other)
Instituto Universitário de Ciências da Saúde Unidade de Investigação em Toxicologia, Portugal
2022/04/07 - 2022/04/08 I Congresso Internacional da TOXRUN, O V Congresso Internacional da APCF¿ e as XIV Jornadas Científicas do IUCS-CESPU (2022/04/07 - 2022/04/08)
Congress (Member of the Organising Committee)
Associação Portuguesa de Ciências Forenses, Portugal

Instituto Universitário de Ciências da Saúde, Portugal
2022/04/07 - 2022/04/08 1st International Congress of UNIPRO Research Unit (IUCS - CESPU), includinh the Conference on Advances in Research on Oral Cancer convened by UNIPRO and the WHO Collaborating Centre on Oral Cancer (2022/04/07 - 2022/04/08)
Congress (Member of the Organising Committee)
Instituto Universitário de Ciências da Saúde, Portugal
2017 - 2019 Workshop do IINFACTS (Annual) (2016 - 2019)
Workshop (Co-organisor)
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2023/05/08 - Current 2º EnantioTox Workshop Series - Análise de dados em biociências com ferramentas open source: uma abordagem prática.
Workshop
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2024/03/07 - 2024/03/07 II Jornadas de Ética da CESPU. “A Ética na Investigação e na vida Universitária”
Conference
II Jornadas de Ética da CESPU. “A Ética na Investigação e na vida Universitária”
Instituto Universitário de Ciências da Saúde, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2021/06/16 - 2023/06/16 Conversations in BioMed. FMCB PhD Alumni Meeting.
Meeting
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2022/10/27 - 2022/10/27 PhD Day 2022
Meeting
PhD Day 2022
Instituto Universitário de Ciências da Saúde, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2022/09/24 - 2022/09/24 4º Encontro Nacional de Jovens Investigadores em Oncologia (4º ENJIO)
Meeting
4º Encontro Nacional de Jovens Investigadores em Oncologia (4º ENJIO)
Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Portugal
2022/09/24 - 2022/09/24 Participação e apresentação de trabalho
Meeting
4º Encontro Nacional de Jovens Investigadores em Oncologia (4º ENJIO)
Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Portugal
2022/07/26 - 2022/07/26 1º EnantioTox Workshop Series - “Elaboração de desenhos, esquemas, mapas, resumos gráficos, literacia e comunicação visual, com recurso ao PowerPoint”. Componentes teórica (1h30)e prática (3h00)
Workshop
1º EnantioTox Workshop Series - “Elaboração de desenhos, esquemas, mapas, resumos gráficos, literacia e comunicação visual, com recurso ao PowerPoint”
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal

Universidade de Trás-os-Montes e Alto Douro, Portugal
2022/04/07 - 2022/04/08 I Congresso Internacional da TOXRUN, O V Congresso Internacional da APCF¿ e as XIV Jornadas Científicas do IUCS-CESPU
Congress
2022/03/01 - 2022/03/01 LSM Plus & Airyscan Joint Deconvolution User Workshop (online)
Workshop
Carl Zeiss AG, Germany
2021/11/25 - 2021/11/27 4ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia ¿ 4ª rRACS, Benguela-Angola (online)
Congress
4ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia – 4ª rRACS, Benguela-Angola
2020/10/27 - 2020/10/28 3ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia 3ª rRACS (online)
Congress
3ª Reunião Internacional da Rede Académica das Ciências da Saúde da Lusofonia – 3ª rRACS
2016/10 - 2016/10 I Congresso Nacional de Ciências Biomédicas Laboratoriais
Congress
I Congresso Nacional de Ciências Biomédicas Laboratoriais
Instituto Politécnico de Bragança, Portugal
2016/04/28 - 2016/04/29 2nd International Congress Aspic
Congress
2nd International Congress Aspic
Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
2014/11/06 - 2014/11/07 INCOMAM'14 - International Conference on Microscopy and Microanalysis, XLVIII Congress of the Portuguese Microscopy Society.
Conference
INCOMAM'14 - International Conference on Microscopy and Microanalysis, XLVIII Congress of the Portuguese Microscopy Society.
2014 - 2014 EMBO Conference Series, 3rd Edition, Microtubules: structure, Regulation and Function
Conference
EMBO Conference Series, 3rd Edition, Microtubules: structure, Regulation and Function
European Molecular Biology Laboratory, Germany
2013 - 2013 XXII Porto Cancer Meeting & III Porto-Bordeaux Joint Meeting
Meeting
XXII Porto Cancer Meeting & III Porto-Bordeaux Joint Meeting
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2013 - 2013 Embo Young Scientists´Forum
Symposium
Embo Young Scientists´Forum
2010/10/29 - 2010/10/29 Meeting Gynecological Cytology: Basic and Advanced Principles
Symposium
Meeting Gynecological Cytology: Basic and Advanced Principles
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2010/09/08 - 2010/09/09 III CICS – UnIPSa – CITS Workshop
Workshop
III CICS – UnIPSa – CITS Workshop
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2010/07/23 - 2010/07/23 “LC-MS/MS Mini-Symposium: from small molecules to macromolecules”
Symposium
“LC-MS/MS Mini-Symposium: from small molecules to macromolecules”
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2009/10/09 - 2009/10/10 II CICS – UnIPSa – CITS Workshop
Workshop
II CICS – UnIPSa – CITS Workshop
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2008/07/24 - 2008/07/24 I CICS – UnIPSa – CITS Workshop: “Research lines”
Workshop
I CICS – UnIPSa – CITS Workshop: “Research lines”
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2008/05/16 - 2008/05/18 X Technical Congress in Pathological Anatomy, Costa da Caparica
Congress
X Technical Congress in Pathological Anatomy, Costa da Caparica
2008/04/15 - 2008/04/16 I Congress of IPSN
Congress
I Congress of IPSN
Instituto Politécnico de Saúde do Norte, Portugal
2008/01/26 - 2008/01/27 V Inter-Service Meeting for Pathological Anatomists in the Area of Cytology
Meeting
V Inter-Service Meeting for Pathological Anatomists in the Area of Cytology
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2007/06/02 - 2007/06/03 IX Technical Congress in Pathological Anatomy
Congress
IX Technical Congress in Pathological Anatomy
Fundação Dr. António Cupertino de Miranda, Portugal
2006/11/28 - 2006/11/29 II APEF Scientific Congress – “Stem Cells and Nanotechnology”
Congress
II APEF Scientific Congress – “Stem Cells and Nanotechnology”
Universidade Portucalense Infante Dom Henrique, Portugal

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2024/07/16 Studies on the Expression of Neurotoxicity Biomarkers Resulting from Exposure to Therapeutic Doses of Tramadol and Tapentadol in Prefrontal Cortex Samples.
(Thesis) Main arguer
Lília da Rocha Rodrigues (Other)
Instituto Universitário de Ciências da Saúde, Portugal
2024/07/11 Recent advances in microtubule targeting agents for cancer therapy.
(Thesis) Main arguer
Henrique Carvalho Assunção (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2023/07/19 Tramadol and Tapentadol: Nephro- and neurotoxicity biomarkers expression after exposing rats to therapeutic doses
(Thesis) Main arguer
Ana Rita Dantas de Barros (Other)
Instituto Universitário de Ciências da Saúde, Portugal
2023/07/11 Evaluation of Chemoresistance Biomarkers in Ovarian Cancer Cell Lines
(Thesis) Main arguer
Anabela Bianca Moreira Costa (Other)
Instituto Universitário de Ciências da Saúde, Portugal
2021/12/17 Caracterização da proteína Mob4 humana. Um estudo da execução da mitose.
(Thesis) Main arguer
Andreia Isabel Alves Colaço (Master)
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2021/07/08 Study of the mechanisms of genotoxicity from subacute exposure to tapentadol
(Thesis) Main arguer
Ana Rita Leite da Silva (Other)
Instituto Universitário de Ciências da Saúde, Portugal
2021/07/08 P-glycoprotein expression analysis in ovarian tumours recurrences.
(Thesis) Main arguer
Henrique da Silva Ferreira (Other)
Instituto Universitário de Ciências da Saúde, Portugal

Committee member

Activity description
Role
Institution / Organization
2023/10/27 - 2023/10/27 Member of the Scientific Committee of the PhD Day 2023 IUCS-CESPU
Member
Instituto Universitário de Ciências da Saúde, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2022/10/27 - 2022/10/27 Member of the Scientific Committee of the PhD Day 2022, IUCS-CESPU
Member
Instituto Universitário de Ciências da Saúde, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2021/09 - Current Morfologia e Funções do Corpo Humano I Ciências Biomédicas (Licenciatura) Instituto Universitário de Ciências da Saúde, Portugal
2021/09 - Current Morfologia e Funções do Corpo Humano III Ciências Biomédicas (Licenciatura) Instituto Universitário de Ciências da Saúde, Portugal
2021/09 - Current Morfologia e Funções do Corpo Humano IV Ciências Biomédicas (Licenciatura) Instituto Universitário de Ciências da Saúde, Portugal
2021/09 - Current Morfologia e Funções do Corpo Humano V Ciências Biomédicas (Licenciatura) Instituto Universitário de Ciências da Saúde, Portugal
2020 - Current Advanced Course in Oncobiology (Teaching) Ciências Biomédicas (Doutoramento) Instituto Universitário de Ciências da Saúde, Portugal
2012 - 2021 Cellular and Molecular Biology Basic Health Sciences (Pós-Graduação) Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2012 - 2021 Cellular and Molecular Biology Dental Medicine (Mestrado integrado) Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2017 - 2018 General histology and embryology Dental Medicine (Mestrado integrado) Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2015 - 2018 Advanced Course in Oncobiology (Teaching) PhD Program in Biological Sciences Applied to Health (Doutoramento) Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2012 - 2018 Cell Biology Pharmaceutical Sciences (Mestrado integrado) Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2011 - 2013 Cell Biology Nutrition Sciences (Licenciatura) Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2011 - 2012 General Molecular and Cellular Biology Forensic Sciences Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2011 - 2012 Human Biology I Clinical Psychology (Licenciatura) Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2010 - 2012 Advanced course in Molecular Pathology (Teaching | Cytopathology Concepts) Molecular Therapy (Mestrado) Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal
2008 - 2011 Biosecurity Pathological, Cytological and Thanatological Anatomy (Licenciatura) Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal

Evaluation committee

Activity description
Role
Institution / Organization Funding entity
2023/12 - 2024/01 Reviewer of a Research Project application for funding by CESPU, under the call GI2-CESPU-2023. Gabinete para a Investigação e a Inovação (GI2) - CESPU Grants. Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal Cooperativa de Ensino Superior Politécnico e Universitário (CESPU)
2022 - 2022 Reviewer of a Research Project application for funding by CESPU, under the call GI2-CESPU-2022. Gabinete para a Investigação e a Inovação (GI2) - CESPU Grants. Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal Cooperativa de Ensino Superior Politécnico e Universitário (CESPU)

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2017 Inibição de proteína associada à divisão celular ajuda no tratamento do cancro - estudo Diário de Notícias
2017 Investigadores do Porto descobrem como levar as células cancerígenas ao "suicídio" SIC Notícias
2017 Eliminação da Spindly: um gatilho para o suicídio de células cancerígenas ASPIC

Journal scientific committee

Journal title (ISSN) Publisher
2024 - Current Molecules MDPI
2024 - Current International Journal of Molecular Sciences MDPI
2024 - Current Frontiers in Oncology Frontiers
2022/06 - Current BMC Cancer Springer Nature
2022/02/24 - Current Cancer Cell International Springer Nature
2022 - Current Frontiers in Pharmacology Frontiers
2013 - Current Cell Proliferation (1365-2184) Wiley (Blackwell Publishing)
Distinctions

Award

2023 Annual Scientific Productivity Award 2023
Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Portugal

Instituto Universitário de Ciências da Saúde, Portugal
2022 Excellence Award from the Portuguese Association of Forensic Sciences - Professor Doctor Duarte Nuno Vieira. II TOXRUN International Congress
Associação Portuguesa de Ciências Forenses, Portugal

MDPI AG, Switzerland
2013 Travel grants EMBO Young Scientists’ Forum
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2013 PhD fellowship (SFRH/BD/90744/2012)
Fundação para a Ciência e Tecnologia (FCT), Portugal