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Bruno Miguel Fernandes Ladeira is a PhD candidate at CICECO - Aveiro Institute of Materials. He completed a Bachelor's program in Biotechnology at the University of Aveiro in 2019 and he obtained a Master's degree in Biotechnology (Molecular Biotechnology branch) in 2021 at the same institution. During the final year of his Bachelor's he participated in a project focused on the synthesis of new porphyrin photosensitizers for antimicrobial photodynamic inactivaction. During his Master's, he wrote a dissertation based on the generation of human protein-derived microsponges for regeneration post-myocardial infarction. His current research interests include the use of innovative techniques to develop core-shell microcapsules for 3D cell culture, and exploiting the supramolecular assembly of human proteins to influence cellular mechanotransduction pathways and promote proper cell-matrix interactions. He currently has 3 published peer-reviewed publications, focusing on the development of novel materials for biomedical applications.
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Identification

Personal identification

Full name
BRUNO MIGUEL FERNANDES LADEIRA

Citation names

  • Ladeira, Bruno
  • Ladeira, B. M. F.
  • Bruno M. Ladeira

Author identifiers

Ciência ID
4B12-7904-C28D
ORCID iD
0000-0002-2684-9278

Addresses

  • Departamento de Química, Universidade de Aveiro, 3810-193, Aveiro, Aveiro, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Biomaterials

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2022/11/01 - 2026/10/31
Ongoing
 Doctoral Program in Biotechnology (Doutoramento)
Universidade de Aveiro CICECO, Portugal
2019/09/11 - 2021/12/06
Concluded
 Biotechnology (Mestrado)
Universidade de Aveiro Departamento de Química, Portugal
"Desenvolvimento de scaffolds com base em lisado de plaquetas a partir de microcápsulas para regeneração pós-enfarte do miocárdio / Development of platelet lysate based scaffolds from microcapsules for regeneration post-myocardial infarction" (THESIS/DISSERTATION)
 19
2016/09/13 - 2019/06/24
Concluded
 Biotechnology (Licenciatura)
Universidade de Aveiro Departamento de Química, Portugal
 19
Affiliation

Science

Category
Host institution 		Employer
2022/11/01 - Current Researcher (Research) Universidade de Aveiro CICECO, Portugal
Universidade de Aveiro CICECO, Portugal
2022/02/15 - 2022/11/15 Researcher (Research) Universidade de Aveiro CICECO, Portugal
Universidade de Aveiro Departamento de Química, Portugal
Projects

Grant

Designation Funders
2022/11/01 - Current Artificial “mini-placenta” biofactories: bioinspired human protein-derived microcapsules for modular bone tissue engineering
2022.10626.BD
PhD Student Fellow
Universidade de Aveiro CICECO, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2022/02/15 - 2022/10/15 Human Platelet Lysates-based Scaffolds for Interfacial Multi-tissue Repair
953169
Research Fellow
Universidade de Aveiro, Portugal
 European Commission
Ongoing
Outputs

Publications

Conference abstract
  1. Bruno M. Ladeira; Maria C. Gomes; Custódio, Catarina A.; Kongchang Wei; Mano, Joao F.. "Leveraging host-guest interactions to produce highly reshapable soft hydrogels from proteins of human origin". Paper presented in 33rd Annual Conference of the European Society for Biomaterials, ESB2023, Davos, 2023.
Conference poster
  1. Ladeira, Bruno; Gomes, Maria Clara; Custódio, A. Catarina; Mano, João F.. "Harnessing supramolecular interactions to assemble amniotic membrane-based granular matrices for cell delivery". Paper presented in SupraLife Third School - Supramolecular Multifunctional Biomaterials, 2025.
  2. Bruno M. Ladeira; Maria C. Gomes; Custódio, Catarina A.; Mano, Joao F.. "Harnessing Human Extracellular Matrix to Produce Self-Curing Granular Hydrogels for Cell Delivery". Paper presented in Jornadas do CICECO 2024, 2024.
  3. Bruno M. Ladeira; Maria C. Gomes; Custódio, Catarina A.; Mano, Joao F.. Corresponding author: Bruno M. Ladeira. "Exploiting Cyclodextrin-Protein Interactions to Generate Dynamic Biomaterials from Human Amniotic Membrane". Paper presented in SupraLife Second School, 2024.
  4. Bruno M. Ladeira; Maria C. Gomes; Custódio, Catarina A.; Mano, Joao F.. "Recreating the dynamic properties of the ECM through cyclodextrin-mediated assembly of human amniotic membrane". Paper presented in Jornadas do CICECO 2023, 2023.
  5. Bruno M. Ladeira; Maria C. Gomes; Custódio, Catarina A.; Mano, Joao F.. Corresponding author: Bruno M. Ladeira. "Exploring host-guest interactions between cyclodextrins and proteins to produce supramolecular amniotic membrane hydrogels". Paper presented in SupraLife First School “Functional Supramolecular Polymeric Biomaterials”, 2023.
  6. Bruno M. Ladeira ; Moura, Nuno M. M.; Ana T. P. C. Gomes ; Almeida, Adelaide; M. G. P. M. S. Neves ; Faustino, M. Amparo F.. "Synthesis and biological evaluation of porphyrin-pyrrolidine conjugates". Paper presented in XXVI Encontro Nacional da Sociedade Portuguesa de Química, 2019.
Journal article
  1. Ladeira, Bruno; Gomes, Maria; Wei, Kongchang; Custódio, Catarina; Mano, João. "Supramolecular assembly of multi-purpose tissue engineering platforms from human extracellular matrix". Biomaterials 320 (2025): 123270. https://doi.org/10.1016/j.biomaterials.2025.123270.
    Open access • Published • 10.1016/j.biomaterials.2025.123270
  2. Ladeira, Bruno Miguel; Gomes, Maria Clara; Custodio, Catarina; Mano, João Filipe Colardelle da Luz. Corresponding author: Mano, João Filipe Colardelle da Luz. "High-Throughput Production of Microsponges from Platelet Lysate for Tissue Engineering Applications". Tissue Engineering Part C: Methods 28 7 (2022): 325-334. http://dx.doi.org/10.1089/ten.tec.2022.0029.
    10.1089/ten.tec.2022.0029
  3. Ladeira, Bruno M.; Custódio, Catarina A.; Mano, João F.. "Core-shell microcapsules: biofabrication and potential applications in tissue engineering and regenerative medicine". Biomaterials Science (2022): http://dx.doi.org/10.1039/d1bm01974k.
    10.1039/d1bm01974k
  4. Ladeira, Bruno M. F.; Dias, Cristina J.; Gomes, Ana T. P. C.; Tomé, Augusto C.; Neves, Maria G. P. M. S.; Moura, Nuno M. M.; Almeida, Adelaide; Faustino, M. Amparo F.. "Cationic Pyrrolidine/Pyrroline-Substituted Porphyrins as Efficient Photosensitizers against E. coli". Molecules 26 2 (2021): 464. http://dx.doi.org/10.3390/molecules26020464.
    10.3390/molecules26020464
Thesis / Dissertation
  1. Ladeira, Bruno Miguel Fernandes. "Development of platelet lysate based scaffolds from microcapsules for regeneration post-myocardial infarction". Master, Universidade de Aveiro CICECO, 2021. http://hdl.handle.net/10773/32992.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/09/30 Building dynamic hydrogels through the cyclodextrin-mediated assembly of human amniotic membrane SupraLife Scientific Retreat 2023 - "Bonding across Borders"
Universidade de Aveiro (Porto, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2025/02/24 - 2025/03/14 SupraLife Third School - Supramolecular Multifunctional Biomaterials (2025/03/09 - 2025/03/14)
Conference (Member of the Organising Committee)
 Universidade de Aveiro, Portugal
2024/03/10 - 2024/03/15 SupraLife Second School - Bioinspired Supramolecular Self-Assemblies (2024/03/10 - 2024/03/15)
Conference (Member of the Organising Committee)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2025/01/24 - 2025/01/24 1st Edition of the Technical Workshop on Rotational Rheology
Workshop
Universidade de Aveiro CICECO, Portugal

Paralab - Equipamentos Industriais e de Laboratório SA, Portugal
2023/10/24 - 2023/10/25 SupraLife "hands-on" workshop
Workshop
Technische Universiteit Eindhoven, Netherlands
2023/04/17 - 2023/04/21 Advanced Course Proteomics Approaches in Life Sciences
Workshop
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Association member

Society Organization name Role
2019 - Current Sociedade Portuguesa de Química Member

Mentoring / Tutoring

Topic Student name
2024/09/17 - 2025/01/06 Advanced Biomaterials and Biomimetics André Ferreira; Bruna Ferreira; Catarina Veiga; Gabriela Neves; Joana Camarinha
2022/09/26 - 2023/02/06 Advanced Biomaterials and Biomimetics Ana Margarida Almeida; Filipa Costa; Miriam Pereira; Patrícia Vigário